{"id":9800,"date":"2017-11-16T18:07:05","date_gmt":"2017-11-16T10:07:05","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&#038;mid=100002292&#038;idx=1&#038;sn=18f3f5c2a262da9fb427466e6a8ba172&#038;chksm=6b72bb435c0532557ac3099b8fdce001def8f99ecd188bad981e2c940b4431d578d98c756d52#rd"},"modified":"2026-04-09T09:38:35","modified_gmt":"2026-04-09T01:38:35","slug":"1015748","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2017\/11\/16\/1015748\/","title":{"rendered":"10\u4f4d\u77e5\u540d\u4e13\u5bb6\u89e3\u8bfb | FDA\u6279\u51c6\u9996\u4e2a\u591a\u764c\u79cd\u591a\u57fa\u56e0\u68c0\u6d4b\u5e73\u53f0"},"content":{"rendered":"<p><!-- wechat_content_hash: e907506f7e0dc32c --><\/p>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDEsUia5jbfibMgeRrNibH1ns0NaxVdCMqRl9Bcn0geKXKbn4CByInShB9u6lDPnKmK1nhKxqqiaRaUzQ.gif\" 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class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYnKYNSbpViblcsrDtIuJFSunEpeUS4weCS9jYVmy0CDgfB0xKmrLhKbw.jpeg\" alt=\"RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYnKYNSbpViblcsrDtIuJFSunEpeUS4weCS9jYVmy0CDgfB0xKmrLhKbw\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe\uff0cDavid Klimstra<\/div>\n<div>MSK\u75c5\u7406\u5b66\u7cfb\u4e3b\u4efbDavid Klimstra\u8bf4\uff1a\u201c\u75c5\u7406\u5b66\u51e0\u4e4e\u53ef\u4ee5\u6307\u5bfc\u764c\u75c7\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u7684\u6bcf\u4e2a\u51b3\u7b56\u70b9\u3002 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class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYe9vILu1LWgTFP6YJwCJNo6TUyjlMIzZMzYw3ba2kYibZBcs83bEYNnA.png\" alt=\"RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYe9vILu1LWgTFP6YJwCJNo6TUyjlMIzZMzYw3ba2kYibZBcs83bEYNnA\"\/><\/figure><\/div>\n\n<div>\u65b9\u6cd5\u8bc4\u4f30\u00a0\u00a0\u00a0 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\u00a0<\/div>\n<div>MSK-IMPACT\u5df2\u88ab\u7ebd\u7ea6\u5dde\u536b\u751f\u90e8\u6279\u51c6\u4e34\u5e8a\u8bd5\u9a8c\u3002\u662f\u7b2c\u4e00\u4e2a\u901a\u8fc7FDA\u83b7\u5f97\u6388\u6743\u7684\u80bf\u7624\u5206\u6790\u5b9e\u9a8c\u5ba4\u5f00\u53d1\u7684\u68c0\u6d4b\u3002\u8fd9\u5c06\u4e3a\u5b66\u672f\u548c\u5546\u4e1a\u5b9e\u9a8c\u5ba4\u5f00\u53d1\u7684\u68c0\u6d4b\u65b9\u6cd5\u7684\u6388\u6743\u521b\u4e0b\u5148\u4f8b\u3002FDA\u5bf9MSK-IMPACT\u2122\u7684\u6388\u6743\u4ee5\u53ca\u6700\u8fd1\u6279\u51c6\u7684\u4e00\u4e9b\u836f\u7269\u6807\u5fd7\u7740\u7cbe\u51c6\u533b\u5b66\u7684\u4e00\u4e2a\u65b0\u9636\u6bb5\u3002\u8fd9\u53ef\u80fd\u4f1a\u5bfc\u81f4\u66f4\u5e7f\u6cdb\u7684\u5bf9\u80bf\u7624\u5b66\u57fa\u56e0\u7ec4\u5408\uff08PANEL\uff09\u6d4b\u5e8f\u7684\u4fdd\u9669\u8986\u76d6\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u5b9e\u7528\u6027\u00a0\u00a0\u00a0 \u00a0<\/div>\n<div>\u4eca\u5e74\u65e9\u4e9b\u65f6\u5019\u5728\u300aNature Medicine\u300b\u6742\u5fd7\u4e0a\u53d1\u8868\u7684\u4e00\u9879\u7814\u7a76\uff0c\u524d10336\u4f8bMSK-IMPACT\u60a3\u8005\u8fdb\u884c\u4e86\u80bf\u7624\u6d4b\u5e8f\uff0c\u5176\u4e2d\u8fd137\uff05\u7684\u60a3\u8005\u81f3\u5c11\u6709\u4e00\u9879\u53ef\u6cbb\u7684\uff08actionable\uff09\u7a81\u53d8\u3002\u8fd9\u610f\u5473\u7740\u9488\u5bf9\u8fd9\u4e9b\u7a81\u53d8\u7684\u836f\u7269\u662f\u53ef\u7528\u7684\u3002\u6839\u636e\u8fd9\u4e9b\u6d4b\u8bd5\u7ed3\u679c\uff0c\u8be5\u62a5\u544a\u62a5\u9053\uff0c11\uff05\u7684\u60a3\u8005\uff08\u7ea61000\u4eba\uff09\u80fd\u591f\u53c2\u4e0e\u76f4\u63a5\u9488\u5bf9\u80bf\u7624\u57fa\u56e0\u6539\u53d8\u7684\u6cbb\u7597\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/div>\n<div>\u00a0<\/div>\n<div>FDA\u6388\u6743\u4f7f\u7528MSK-IMPACT\u7684\u4e00\u4e2a\u91cd\u8981\u7ec4\u6210\u90e8\u5206\u662fMSI\u68c0\u6d4b\u3002\u4eca\u5e745\u6708\uff0c\u7f8e\u56fdFDA\u6279\u51c6\u4e86PD-1\u6297\u4f53Keytruda 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\u00a0<\/div>\n<div>\u6240\u6709\u901a\u8fc7MSK-IMPACT\u68c0\u6d4b\u6536\u96c6\u7684\u6570\u636e\uff0c\u90fd\u5c06\u901a\u8fc7MSK\u5f00\u53d1\u7684\u6570\u636e\u5e93cBioPortal\u63d0\u4f9b\u7ed9\u5e7f\u6cdb\u7684\u79d1\u5b66\u540c\u4ec1\u3002\u4e3a\u4e86\u4fdd\u62a4\u9690\u79c1\uff0c\u60a3\u8005\u7684\u8eab\u4efd\u7b49\u8bc6\u522b\u4fe1\u606f\u88ab\u5220\u9664\uff0c\u4f46\u5305\u62ec\u57fa\u672c\u7684\u4e34\u5e8a\u6570\u636e\u3002MSK-IMPACT\u7684\u6570\u636e\u4e5f\u5c06\u901a\u8fc7\u516b\u4e2a\u524d\u6cbf\u764c\u75c7\u4e2d\u5fc3\u53c2\u4e0e\u7684\u00a0AACR GENIE\u9879\u76ee\u5171\u4eab\uff0c GENIE\uff08Genomics Evidence Neoplasia Information Exchange\uff09\u9879\u76ee\u7531\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\uff08AACR\uff09\u521b\u5efa\uff0c\u7531MSK\u4eba\u7c7b\u80bf\u7624\u548c\u53d1\u75c5\u673a\u5236\u9879\u76ee\u4e3b\u5e2d Charles Sawyers\u9886\u5bfc\u3002 MSK\u4e3a\u8be5\u9879\u76ee\u8d21\u732e\u4e86\u6700\u5927\u6bd4\u4f8b\u7684\u75c5\u4eba\uff0c\u5176\u4e2d\u5305\u62ecCMO\u8d44\u52a9\u6ca1\u6709\u4fdd\u9669\u7684\u60a3\u8005\u3002<\/div>\n<div>\u00a0<\/div>\n<div>3\u3001\u884c\u4e1a\u4e13\u5bb6\u548c\u4f01\u4e1a\u4ee3\u8868\u89e3\u8bfb<\/div>\n<div>\u5982\u4f55\u89e3\u8bfb\u548c\u7406\u89e3\u8fd9\u4e00\u91cd\u5927\u4e3e\u63aa\u7684\u610f\u4e49\u4ee5\u53ca\u5bf9\u884c\u4e1a\u7684\u5f71\u54cd\u3002\u57fa\u56e0\u6167\u7279\u9080\u77e5\u540d\u4e13\u5bb6\u548c\u80bf\u7624\u4f01\u4e1a\u4ee3\u8868\u53c2\u4e0e\u89e3\u8bfb\u8ba8\u8bba\uff0c\u5206\u4eab\u5982\u4e0b\uff08\u611f\u8c22\u5404\u4f4d\u53c2\u4e0e\uff0c\u4ee5\u4e0b\u4ec5\u4ee3\u8868\u5609\u5bbe\u89c2\u70b9\uff09\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYCHvwYflPN7LWtXuBqvicicoPeuOKTvVO2lXvvkG6a3HxY8RQZdOibn6nQ.png\" alt=\"RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYCHvwYflPN7LWtXuBqvicicoPeuOKTvVO2lXvvkG6a3HxY8RQZdOibn6nQ\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u6768\u864e\u5c71<\/div>\n\n<div style=\"text-align: center;\">\u00a0Sidney Kimmel\u764c\u75c7\u4e2d\u5fc3\u533b\u5b66\u80bf\u7624\u5b66\u7cfb\u526f\u6559\u6388\uff0c\u5faa\u73af\u80bf\u7624\u7ec6\u80de\u4e2d\u5fc3\u5b9e\u9a8c\u5ba4\u4e3b\u4efb<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYjibGnPBxG38GpPJGWfTibsQfXKuib2l0hffaITc8ibYbk2bul7siaZZ0u1A.png\" alt=\"RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYjibGnPBxG38GpPJGWfTibsQfXKuib2l0hffaITc8ibYbk2bul7siaZZ0u1A\"\/><\/figure><\/div>\n\n<\/div>\n<div><\/div>\n<div>\u201c\u4eca\u5929\u5bf9\u4e8e\u4e2d\u7f8e\u7684\u80bf\u7624\u7cbe\u51c6\u533b\u7597\u9886\u57df\u90fd\u662f\u4e00\u4e2a\u975e\u5e38\u91cd\u8981\u7684\u91cc\u7a0b\u7891\uff0c\u5728\u4eca\u5929\u7684\u6279\u51c6\u8bf4\u660e\u91cc\u9762\uff0cFDA\u7684Commissioner Scott Gottlieb 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class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYPOSGsV2AlxaOTEYicj05UT6LLVhYjicCAl0ItD0gtgawDPZ15XUlAsBg.jpeg\" alt=\"RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYPOSGsV2AlxaOTEYicj05UT6LLVhYjicCAl0ItD0gtgawDPZ15XUlAsBg\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u4efb\u5584\u6210<\/div>\n\n<div style=\"text-align: center;\">\u00a0\u6d77\u519b\u519b\u533b\u5927\u5b66\uff08\u7b2c\u4e8c\u519b\u533b\u5927\u5b66\uff09\u9644\u5c5e\u957f\u6d77\u533b\u9662\u6ccc\u5c3f\u5916\u79d1\u6559\u6388 \u9752\u5e74\u957f\u6c5f\u5b66\u8005 \u00a0\u00a0<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYjibGnPBxG38GpPJGWfTibsQfXKuib2l0hffaITc8ibYbk2bul7siaZZ0u1A.png\" alt=\"RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYjibGnPBxG38GpPJGWfTibsQfXKuib2l0hffaITc8ibYbk2bul7siaZZ0u1A\"\/><\/figure><\/div>\n\n<\/div>\n<div><\/div>\n<div>\u201c\u4f5c\u4e3a\u57fa\u56e0\u68c0\u6d4b\u7684\u534a\u4e2a\u4e1a\u5185\u4eba\u58eb\uff0c\u6211\u4e3a\u6b64\u611f\u5230\u7531\u8877\u7684\u9ad8\u5174\uff01\u53ef\u4ee5\u9884\u89c1\u7684\u662f\uff0c\u56fd\u5185\u76d1\u7ba1\u90e8\u95e8\u5f88\u5feb\u6709\u7c7b\u4f3c\u8ddf\u8fdb\u7684\u884c\u52a8\uff0c\u4e00\u5377\u6ce2\u6f9c\u58ee\u9614\u7684\u753b\u9762\u6b63\u5728\u5c55\u5f00\u3002\u4ece\u4eca\u5e746\u670823\u65e5FDA\u6279\u51c6\u4e86\u9996\u4e2a\u57fa\u4e8eNGS\u6280\u672f\u3001\u53ef\u4ee5\u5206\u67903\u79cd\u975e\u5c0f\u7ec6\u80de\u80ba\u764c(NSCLC)\u6cbb\u7597\u4e2d\u7684\u53cd\u5e94\u53d8\u5316\u7684\u4f34\u968f\u8bca\u65ad\u8bd5\u5242\u76d2\uff0c\u5230\u5982\u4eca\u7684NGS\u764c\u75c7\u5927panel\u57fa\u56e0\u68c0\u6d4b\uff0cFDA\u7684\u52a8\u4f5c\u9010\u6e10\u52a0\u5feb\uff0c\u201c\u5206\u5b50\u75c5\u7406\u201d\u4e5f\u9010\u6e10\u7531\u6982\u5ff5\u53d8\u4e3a\u73b0\u5b9e\u3002\u7136\u800c\uff0c\u4f5c\u4e3a\u4e00\u540d\u4e34\u5e8a\u533b\u751f\uff0c\u6211\u4eec\u66f4\u5173\u6ce8\u7684\u662f\u75c5\u4eba\u7684\u83b7\u76ca\uff0c\u8bca\u65ad\u4e0d\u662f\u76ee\u7684\uff0c\u6cbb\u7597\u624d\u662f\u738b\u9053\uff01<\/div>\n<div><\/div>\n<div>MSK-IMPACT\u5bf9\u75c5\u4eba\u80bf\u7624468\u4e2a\u57fa\u56e0\u7684\u7a81\u53d8\u3001\u62f7\u8d1d\u6570\u53d8\u5316\uff08CNAs\uff09\u3001\u542f\u52a8\u5b50\u7a81\u53d8\u548c\u57fa\u56e0\u7ec4\u91cd\u6392\u8fdb\u884c\u68c0\u6d4b\uff0c\u8fd9\u4e9b\u57fa\u56e0\u79f0\u4e3a\u201cActionable Targets\u201d\uff0c\u6839\u636e\u8fd9\u4e9b\u68c0\u6d4b\u7ed3\u679c\u9009\u62e9\u76f8\u5e94\u7684\u9776\u5411\u836f\u7269\uff0c\u5230\u5e95\u6709\u591a\u5c11\u6bd4\u4f8b\u7684\u60a3\u8005\u83b7\u76ca\u662f\u5173\u952e\u3002\u65e9\u57282015\u5e74\uff0c\u300aCell\u300b\u4e0a\u53d1\u8868\u6587\u7ae0\u5ba3\u79f089%\u7684\u665a\u671f\u524d\u5217\u817a\u764c\u53ef\u4ee5\u627e\u5230Actionable Mutations\uff0c\u8fd9\u662f\u4e0d\u662f\u610f\u5473\u7740\u8fd9\u4e9b\u60a3\u8005\u90fd\u4f1a\u5bf9\u76f8\u5e94\u7684\u836f\u7269\u6709\u53cd\u5e94\uff0c\u503c\u5f97\u5546\u69b7 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class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYYBqFIdTqBH3M3d94QML8cwD9doP9mPpPmVX40vPZEV7YQh9anyHVRg.png\" alt=\"RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYYBqFIdTqBH3M3d94QML8cwD9doP9mPpPmVX40vPZEV7YQh9anyHVRg\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u63e3\u5c11\u5764<\/div>\n\n<div style=\"text-align: center;\">\u00a0\u71c3\u77f3\u533b\u5b66\u9996\u5e2d\u8fd0\u8425\u5b98 \u00a0\u00a0<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAYeStXnU2BPXWL99aYibD1HFIf0zzaHY3bjMrUfbFibgxneJsRG40u4zHHicib6c4U9sm2y2PdWLiaIvA.png\" alt=\"RmFicvQBAkgAYeStXnU2BPXWL99aYibD1HFIf0zzaHY3bjMrUfbFibgxneJsRG40u4zHHicib6c4U9sm2y2PdWLiaIvA\"\/><\/figure><\/div>\n\n<\/div>\n<div><\/div>\n<div>\u201c\u7531\u4e8e\u6b64\u524d\u4e0d\u8bbaFDA\u8fd8\u662fCFDA\uff0c\u5bf9\u4e8e\u57fa\u4e8eNGS\u7684\u80bf\u7624\u8bca\u65ad\u4ea7\u54c1\u7684\u5ba1\u6279\u8def\u5f84\u90fd\u662f\u5177\u4f53\u5230\u4e0e\u836f\u7269\u7597\u6548\u76f8\u5173\u7684\u53d8\u5f02\u4f4d\u70b9\u7684\uff0c\u8fd9\u6b21\u5ba1\u6279\u6027\u7684\u8de8\u8d8a\uff0c\u8ba9\u6211\u4eec\u7b2c\u4e00\u6b21\u770b\u5230\u4e86\u57fa\u4e8e\u6574\u4e2apanel\u53ca\u76f8\u5e94\u7684\u6280\u672f\u5e73\u53f0\uff0c\u800c\u975e\u7279\u5b9a\u57fa\u56e0\u7684\u7279\u5b9a\u4f4d\u70b9\uff0c\u6765\u8fdb\u884c\u5ba1\u6279\u7684\u5b9e\u4f8b\u3002<\/div>\n<div><\/div>\n<div>\u9996\u5148\uff0c\u8fd9\u662f\u968f\u7740\u6280\u672f\u4e0e\u79d1\u5b66\u7684\u53d1\u5c55\u800c\u50ac\u751f\u7684\u76d1\u7ba1\u65b9\u5f0f\u7684\u6539\u9769\u4e0e\u521b\u65b0\uff0c\u4e0e\u4f20\u7edf\u65b9\u6cd5\u76f8\u6bd4\uff0cNGS\u7684\u6280\u672f\u5e73\u53f0\u7279\u70b9\u5c31\u5728\u4e8e\u53ef\u4ee5\u5e73\u884c\u68c0\u6d4b\u591a\u57fa\u56e0\u591a\u4f4d\u70b9\u591a\u79cd\u53d8\u5f02\u5f62\u5f0f\uff0c\u800c\u68c0\u6d4b\u6027\u80fd\u4e0e\u53c2\u6570\u5728\u540c\u4e00\u6280\u672f\u5e73\u53f0\u540c\u7c7b\u578b\u53d8\u5f02\u7684\u4e0d\u540c\u57fa\u56e0\u6216\u4f4d\u70b9\u4e0a\u5177\u6709\u9ad8\u5ea6\u7684\u4e00\u81f4\u6027\uff0c\u65e0\u9700\u4e5f\u65e0\u6cd5\u9488\u5bf9\u6240\u6709\u4f4d\u70b9\u4e00\u4e00\u9a8c\u8bc1\u3002\u800c\u540c\u65f6\u968f\u7740\u80bf\u7624\u7684\u5206\u5b50\u6807\u5fd7\u7269\u77e5\u8bc6\u4e0d\u65ad\u66f4\u65b0\uff0c\u4e0e\u7528\u836f\u654f\u611f\u6027\u3001\u6297\u836f\u6027\u3001\u9884\u540e\u7b49\u591a\u79cd\u4e34\u5e8a\u4ef7\u503c\u5bc6\u5207\u76f8\u5173\u7684\u57fa\u56e0\u53d8\u5f02\u88ab\u4e0d\u65ad\u53d1\u73b0\uff0c\u56e0\u6b64\uff0c\u4f9d\u636e\u4f4d\u70b9\u7684\u5ba1\u6279\u65b9\u5f0f\u5728NGS\u4ea7\u54c1\u4e0a\u5448\u73b0\u4e86\u4e00\u5b9a\u7684\u5c40\u9650\u6027\u3002FDA\u7684\u8fd9\u4e00\u52a8\u4f5c\uff0c\u4e5f\u8ba9\u6211\u4eec\u770b\u5230\u4e86\u76d1\u7ba1\u90e8\u95e8\u5728\u7406\u5ff5\u4e0a\u7531\u4f4d\u70b9\u5411panel\u548c\u5e73\u53f0\u8de8\u8d8a\u7684\u8d8b\u52bf\u3002<\/div>\n<div><\/div>\n<div>\u7136\u800c\uff0c\u4ed4\u7ec6\u7814\u8bfbFDA\u7684\u5ba1\u6279\u8d44\u6599\u6211\u4eec\u4e0d\u96be\u53d1\u73b0\uff0c\u4e0d\u8bba\u662fMSK-IMPACT\u6240\u63d0\u4f9b\u7684\u57fa\u4e8e\u5de8\u5927\u6837\u672c\u91cf\u7684\u6027\u80fd\u9a8c\u8bc1\u6570\u636e\uff0c\u8fd8\u662fFDA\u4f34\u968fClass II approval\u6240\u7ed9\u51fa\u7684\u88ab\u79f0\u4e3a&#8221;specific controls&#8221;\u7684\u4e00\u7cfb\u5217\u8865\u5145\u6761\u4ef6\uff0c\u90fd\u80fd\u4f53\u73b0\u51fa\u8fd9\u4e00\u5ba1\u6279\u7684\u8c28\u614e\u6027\u3002\u5c24\u5176\u662fFDA\u7ed9\u51fa\u7684\u8865\u5145\u6761\u4ef6\u4e2d\uff0c\u7279\u522b\u5f3a\u8c03\u4e86panel\u68c0\u6d4b\u8303\u7574\u5fc5\u987b\u9488\u5bf9\u6709\u660e\u786e\u4e34\u5e8a\u610f\u4e49\u7684\u57fa\u56e0\u7a81\u53d8\uff0c\u800c\u4e34\u5e8a\u610f\u4e49\u5e94\u6765\u81ea\u884c\u4e1a\u6307\u5357\u3002\u71c3\u77f3\u4f5c\u4e3aNGS\u80bf\u7624\u68c0\u6d4b\u7684\u540c\u4e1a\uff0c\u6df1\u611f\u7531\u4e8e\u6280\u672f\u5e73\u53f0\u3001\u6570\u636e\u5206\u6790\u3001\u7a81\u53d8\u89e3\u8bfb\u7b49\u591a\u4e2a\u65b9\u9762\u7684\u590d\u6742\u6027\uff0c\u5bf9NGS\u68c0\u6d4b\u5728\u80bf\u7624\u4e0a\u7684\u5e94\u7528\u4ea7\u54c1\u8fdb\u884c\u4e25\u8c28\u7684\u76d1\u7ba1\u662f\u6781\u5176\u5fc5\u8981\u7684\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u4e00\u65b9\u9762\u4e3a\u884c\u4e1a\u5728\u5ba1\u6279\u65b9\u5f0f\u4e0a\u5411\u79d1\u5b66\u8fdb\u5c55\u9760\u8fd1\u7684\u8d8b\u52bf\u559d\u5f69\uff0c\u4e00\u65b9\u9762\u4e5f\u8ba4\u4e3a\u8c28\u614e\u4e25\u683c\u7684\u5ba1\u6279\u4e0e\u76d1\u7ba1\u6d41\u7a0b\u5c06\u7ee7\u7eed\u5728\u672a\u6765\u975e\u5e38\u957f\u7684\u65f6\u95f4\u5185\u5b58\u5728\u3002\u201d<\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYGfFO9jwqmoXKphj9TXNNYkjwC2Y0LqACqoibWCTZ6k3eImeqiaMWgmyg.jpeg\" alt=\"RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYGfFO9jwqmoXKphj9TXNNYkjwC2Y0LqACqoibWCTZ6k3eImeqiaMWgmyg\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u6768\u73b2<\/div>\n\n<div style=\"text-align: center;\">\u00a0\u5409\u56e0\u52a0\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98 \u00a0<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYjibGnPBxG38GpPJGWfTibsQfXKuib2l0hffaITc8ibYbk2bul7siaZZ0u1A.png\" alt=\"RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYjibGnPBxG38GpPJGWfTibsQfXKuib2l0hffaITc8ibYbk2bul7siaZZ0u1A\"\/><\/figure><\/div>\n\n<\/div>\n<div><\/div>\n<div>\u201c\u7f8e\u56fdFDA\u5bf9\u4e8e\u521b\u65b0\u548cNGS\u65b0\u6280\u672f\u5728\u80bf\u7624\u7cbe\u51c6\u533b\u7597\u9886\u57df\u5e94\u7528\u7684\u652f\u6301\u4ee4\u6574\u4e2a\u884c\u4e1a\u90fd\u53d7\u5230\u9f13\u821e\uff0c\u5409\u56e0\u52a0\uff08Gene+\uff09\u4f5c\u4e3a\u8be5\u9886\u57df\u7684\u5021\u5bfc\u8005\u548c\u5b9e\u8df5\u8005\uff0c\u6df1\u4fe1\u521b\u65b0\u548c\u89c4\u8303\u540c\u884c\uff0c\u4e0d\u7ba1\u662fIVD\u6a21\u5f0f\u8fd8\u662fLDT\u6a21\u5f0f\uff0c\u6309\u7167\u4e34\u5e8a\u68c0\u9a8c\u7684\u5185\u5728\u8981\u6c42\u505a\u597d\u4ea7\u54c1\u7684\u6027\u80fd\u9a8c\u8bc1\u548c\u4e34\u5e8a\u68c0\u9a8c\u7684\u8d28\u91cf\u4f53\u7cfb\u8fd0\u884c\uff0c\u540c\u65f6\u5409\u56e0\u52a0\u575a\u6301\u4ee5\u5168\u764c\u79cd\u3001\u5168\u8986\u76d6\u3001\u5168\u75c5\u7a0b\u7684\u8bbe\u8ba1\u601d\u8def\uff0c\u57fa\u4e8e\u80bf\u7624\u57fa\u56e0\u5927\u6570\u636e\uff0c\u8fdb\u884c\u5168\u8d2f\u7a7f\u52a8\u6001\u5206\u6790\u4e0e\u4e34\u5e8a\u89e3\u8bfb\uff0c\u5b9e\u73b0\u5bf9\u4e0d\u540c\u9636\u6bb5\u7684\u80bf\u7624\u60a3\u8005\u8fdb\u884c\u5168\u75c5\u7a0b\u670d\u52a1\uff0c\u4ece\u79d1\u7814\u601d\u7ef4\u8f6c\u53d8\u4e3a\u4e34\u5e8a\u68c0\u9a8c\u601d\u7ef4\uff0c\u505a\u51fa\u771f\u6b63\u6ee1\u8db3\u4e34\u5e8a\u9700\u6c42\u3001\u5f15\u9886\u884c\u4e1a\u53d1\u5c55\u7684\u597d\u4ea7\u54c1\u53ca\u9ad8\u8d28\u91cf\u7684\u4e34\u5e8a\u68c0\u6d4b\u670d\u52a1\u9700\u8981\u884c\u4e1a\u5185\u6bcf\u4e00\u5bb6\u4f01\u4e1a\u7684\u5171\u540c\u52aa\u529b\u201d<\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYdicuqribdlaBQen7lrPIby7gtcH4xZicVNhWf68gZILbF1nRpe8CaiaIEA.jpeg\" alt=\"RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYdicuqribdlaBQen7lrPIby7gtcH4xZicVNhWf68gZILbF1nRpe8CaiaIEA\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u5f20\u6653\u5e73<\/div>\n\n<div style=\"text-align: center;\">\u00a0\u6df1\u5733\u534e\u5927\u57fa\u56e0\u80a1\u4efd\u6709\u9650\u516c\u53f8 \u80bf\u7624\u4e8b\u4e1a\u90e8 \u603b\u7ecf\u7406 \u00a0<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYjibGnPBxG38GpPJGWfTibsQfXKuib2l0hffaITc8ibYbk2bul7siaZZ0u1A.png\" alt=\"RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYjibGnPBxG38GpPJGWfTibsQfXKuib2l0hffaITc8ibYbk2bul7siaZZ0u1A\"\/><\/figure><\/div>\n\n<\/div>\n<div><\/div>\n<div>\u201c\u8be5\u591a\u57fa\u56e0\u68c0\u6d4b\u7528\u4ee5\u5168\u9762\u68c0\u6d4b\u60a3\u8005\u7684\u57fa\u56e0\u7a81\u53d8\u60c5\u51b5\uff0c\u4fbf\u4e8e\u5bfb\u627e\u60a3\u8005\u80bf\u7624\u7684\u6700\u4f73\u7597\u6cd5\uff0c\u5e2e\u52a9\u544a\u77e5\u5982\u4f55\u66f4\u597d\u7684\u6cbb\u7597\u764c\u75c7\u3002\u8be5\u6388\u6743\u5177\u6709\u91cd\u8981\u610f\u4e49\uff0c\u6807\u5fd7\u672a\u6765\u5bf9\u4e8e\u533b\u5b66\u548c\u5546\u4e1a\u5b9e\u9a8c\u5ba4\u5f00\u53d1\u7684\u57fa\u56e0\u68c0\u6d4b\u4ea7\u54c1\u7684\u6388\u6743\u5f00\u521b\u4e86\u5148\u4f8b\uff0c\u7cbe\u51c6\u533b\u5b66\u7684\u53d1\u5c55\u8fdb\u5165\u4e86\u4e00\u4e2a\u65b0\u7684\u9636\u6bb5\uff0c\u540c\u65f6\u5f00\u542f\u4e86\u7cbe\u51c6\u533b\u7597\u7684\u591a\u57fa\u56e0\u68c0\u6d4b\u4e4b\u8def\uff0c\u4e3a\u6307\u5bfc\u764c\u75c7\u6cbb\u7597\u63d0\u4f9b\u901a\u8fc7\u591a\u57fa\u56e0\u68c0\u6d4b\u6307\u5bfc\u7684\u601d\u8def\u5960\u5b9a\u89c4\u5219\u4fdd\u969c\u3002\u4e3a\u63a8\u8fdb\u57fa\u4e8e\u4e8c\u4ee3\u6d4b\u5e8f\u6280\u672f\u7684\u764c\u75c7\u591a\u57fa\u56e0\u68c0\u6d4b\u7684\u8bc4\u5ba1\u5236\u5ea6\u63d0\u4f9b\u5168\u7403\u793a\u8303\u4f5c\u7528\u3002\u5728\u6b64\u6b21FDA\u7684\u83b7\u6279\u4e0b\uff0c\u5bf9CFDA\u5c06NGS\u5e94\u7528\u4e34\u5e8a\u7684\u51c6\u5165\u89c4\u5219\u63d0\u4f9b\u91cd\u8981\u7684\u53c2\u8003\u4f9d\u636e\u3002\u672a\u6765\u53ef\u80fd\u4f1a\u5bfc\u81f4\u9488\u5bf9\u57fa\u4e8eNGS\u6280\u672f\u7684\u80bf\u7624\u591a\u57fa\u56e0\u68c0\u6d4b\u4ea7\u54c1\u7684\u4fdd\u9669\u8986\u76d6\uff0c\u5e76\u5f15\u7533\u5bf9\u7c7b\u4f3c\u8bc4\u4ef7MSI\u3001TMB\u7b49\u63d0\u4f9b\u4e34\u5e8a\u51c6\u5165\u5f00\u8f9f\u53ef\u5faa\u4e4b\u8def\u3002\u671f\u671b\u5728\u7cbe\u51c6\u533b\u5b66\u521b\u65b0\u9053\u8def\u4e0a\uff0cCFDA\u4e0d\u4ec5\u662f\u8981\u5b66\u4e60\u4e0e\u8ddf\u968fFDA\uff0c\u66f4\u5e94\u8d85\u8d8a\u3002\u201d<\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYvAiaRI5vq1HrTdiaicMwIYYDHD1sNDEt7vpsJF2hFFqwW27j97kPovcJQ.png\" alt=\"RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYvAiaRI5vq1HrTdiaicMwIYYDHD1sNDEt7vpsJF2hFFqwW27j97kPovcJQ\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u7530\u57c2<\/div>\n\n<div style=\"text-align: center;\">\u00a0\u5143\u7801\u57fa\u56e0\u521b\u59cb\u4eba\u517cCEO\u00a0 \u00a0<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYjibGnPBxG38GpPJGWfTibsQfXKuib2l0hffaITc8ibYbk2bul7siaZZ0u1A.png\" alt=\"RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYjibGnPBxG38GpPJGWfTibsQfXKuib2l0hffaITc8ibYbk2bul7siaZZ0u1A\"\/><\/figure><\/div>\n\n<\/div>\n<div><\/div>\n<div>\u201cMSK IMPACT\u62ff\u5230FDA\u7684\u8ba4\u8bc1\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u5386\u53f2\u4e8b\u4ef6\u3002\u80bf\u7624\u7cbe\u51c6\u533b\u7597\u5df2\u7ecf\u4ece\u6982\u5ff5\u9636\u6bb5\u53d1\u5c55\u5230\u4e34\u5e8a\u5b9e\u8df5\u9636\u6bb5\u3002 \u9996\u5148\u8bc1\u660e\u4e86\u80bf\u7624\u591a\u57fa\u56e0panel\u68c0\u6d4b\u5728\u4e34\u5e8a\u4e0a\u7684\u5b9e\u7528\u6027\u3002<\/div>\n<div><\/div>\n<div>MSK IMPACT\u5728\u62ff\u5230FDA\u8ba4\u8bc1\u4e4b\u524d\uff0c\u5df2\u7ecf\u53d1\u8868\u8fc723\u7bc7\u6587\u7ae0\uff0c\u5176\u5185\u5bb9\u8986\u76d6\u4e86\u4ece\u6280\u672f\u9a8c\u8bc1\uff0c\u5230\u80ba\u764c\u3001\u4e73\u817a\u764c\u7b49\u5404\u79cd\u80bf\u7624\u7c7b\u578b\u7684\u4e34\u5e8a\u5b9e\u9a8c\u6570\u636e\uff0c\u518d\u5230\u603b\u7ed3\u4e00\u4e07\u4f8b\u80bf\u7624\u7684\u7efc\u5408\u6027\u4e34\u5e8a\u6570\u636e\uff0c\u8d85\u8fc7\u4e86\u4e4b\u524dFDA\u5bf9\u4e34\u5e8a\u5b9e\u9a8c\u6837\u672c\u7684\u8981\u6c42\u3002\u6b63\u5411\u7684\u4e34\u5e8a\u6570\u636e\u5bf9\u62ff\u5230FDA\u8ba4\u8bc1\u8d77\u5230\u4e86\u5173\u952e\u6027\u4f5c\u7528\uff0c<\/div>\n<div><\/div>\n<div>\u7b2c\u4e00\u4e2a\u80bf\u7624\u591a\u57fa\u56e0panel\u68c0\u6d4b\u7684\u8ba4\u8bc1\uff0c\u662f\u6240\u6709\u4e34\u5e8a\u8bca\u65ad\u5b9e\u9a8c\u7c7b\u578b\u91cc\u6700\u96be\u7684\uff0c\u56e0\u4e3a\u6bcf\u4e2a\u57fa\u56e0\u90fd\u5305\u542b\u591a\u4e2a\u53ef\u80fd\u7684\u7a81\u53d8\u4f4d\u70b9\uff0c\u591a\u4e2a\u57fa\u56e0\u4e2d\u7684\u7a81\u53d8\u4f4d\u70b9\u5219\u6210\u5343\u4e0a\u4e07\uff0c\u628a\u6bcf\u4e00\u4e2a\u4f4d\u70b9\u90fd\u505a\u5230\u4e25\u683c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7684\u53ef\u80fd\u6027\u51e0\u4e4e\u4e3a\u96f6\u3002FDA\u6839\u636e\u7cbe\u51c6\u533b\u7597\u7684\u8981\u6c42\u5c06\u539f\u6709\u5355\u57fa\u56e0\u3001\u5355\u9776\u70b9\u3001\u5355\u836f\u7269\u7684\u4e34\u5e8a\u5b9e\u9a8c\u601d\u8def\uff0c\u6539\u4e3a\u201c\u7cbe\u51c6FDA\u201d\u7406\u8bba\u6307\u5bfc\u4e0b\u7684\u591a\u57fa\u56e0\u3001\u591a\u4f4d\u70b9\u3001\u591a\u836f\u7269\u7684\u4e34\u5e8a\u5b9e\u9a8c\u57fa\u7840\u3002\u5141\u8bb8\u591a\u57fa\u56e0panel\u8fc5\u901f\u901a\u8fc7FDA\u8ba4\u8bc1\uff0c\u5bf9\u5176\u672a\u6765\u5728\u4e34\u5e8a\u65b9\u5411\u7684\u4f7f\u7528\u6253\u5f00\u4e86\u65b0\u7684\u5c40\u9762\u3002\u76f8\u4fe1\u591a\u57fa\u56e0panel\u8ba4\u8bc1\u7684\u5b9e\u73b0\uff0c\u624d\u80fd\u771f\u6b63\u7684\u652f\u6491\u672a\u6765\u201c\u5f02\u75c5\u540c\u6cbb\u201d\u548c\u201c\u540c\u75c5\u5f02\u6cbb\u201d\u7684\u4e34\u5e8a\u5b9e\u8df5\uff0c\u4e3a\u80bf\u7624\u60a3\u8005\u771f\u6b63\u901a\u8fc7\u5206\u5b50\u5206\u578b\u6765\u8fdb\u884c\u6cbb\u7597\u63d0\u4f9b\u57fa\u7840\u3002\u00a0<\/div>\n<div><\/div>\n<div>\u80bf\u7624\u7684TMB\u3001MSI\u7b49\u68c0\u6d4b\u7684\u8054\u5408\u53ef\u4ee5\u8bf4\u662f\u672a\u6765\u7684\u8d8b\u52bf\uff0c\u8fd9\u4e00\u8054\u5408\u7684\u57fa\u7840\u5c31\u662fFDA\u80fd\u591f\u901a\u8fc7\u8bc4\u5ba1\u901a\u9053\u5bf9\u8fd9\u4e9b\u68c0\u6d4b\u6280\u672f\u8fdb\u884c\u5168\u9762\u7684\u8bc4\u4ef7\uff0c\u8fd9\u6b21FDA\u7684\u8ba4\u8bc1\u6253\u5f00\u4e86\u6574\u4e2a\u884c\u4e1a\u7684\u5bf9\u672a\u6765\u7684\u60f3\u8c61\u7a7a\u95f4\u3002 \u540c\u65f6\uff0c\u6211\u4eec\u671f\u671bCFDA\u80fd\u591f\u53c2\u8003FDA\u901a\u8fc7\u80bf\u7624\u591a\u57fa\u56e0panel\u68c0\u6d4b\u7684\u6d41\u7a0b\uff0c\u80fd\u591f\u8ba9\u56fd\u4eba\u76f8\u5173\u9057\u4f20\u80cc\u666f\u7684\u80bf\u7624\u591a\u57fa\u56e0panel\u68c0\u6d4b\u8fc5\u901f\u4e0a\u5e02\uff0c\u9020\u798f\u66f4\u591a\u4e2d\u56fd\u7684\u60a3\u8005\u3002\u201d<\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYuDGV2avgeClNibeCLPEGvicL7ibxh7DFOFDLrXdyv3b197icuGMQMT3ehw.jpeg\" alt=\"RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYuDGV2avgeClNibeCLPEGvicL7ibxh7DFOFDLrXdyv3b197icuGMQMT3ehw\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u8bb8\u660e\u708e<\/div>\n\n<div style=\"text-align: center;\">\u00a0\u6d77\u666e\u6d1b\u65af\u521b\u59cb\u4eba\u517cCEO\u00a0 \u00a0<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYjibGnPBxG38GpPJGWfTibsQfXKuib2l0hffaITc8ibYbk2bul7siaZZ0u1A.png\" alt=\"RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYjibGnPBxG38GpPJGWfTibsQfXKuib2l0hffaITc8ibYbk2bul7siaZZ0u1A\"\/><\/figure><\/div>\n\n<\/div>\n<div><\/div>\n<div>\u201c\u53bb\u5e74\u4e00\u7bc7\u8c08\u5230\u7cbe\u51c6\u533b\u7597\u6ce1\u6cab\u7684\u6587\u7ae0\uff0c\u4e3b\u8981\u8bba\u70b9\u5c31\u662f\u7cbe\u51c6\u6cbb\u7597\u96be\u4ee5\u5b9e\u73b0\uff0c\u56e0\u4e3a\u9996\u5148\u9776\u5411\u836f\u7269\u7684\u9009\u62e9\u6709\u9650\uff0c\u5176\u6b21\u80bf\u7624\u5177\u6709\u5f02\u8d28\u6027\uff0c\u9776\u5411\u6cbb\u7597\u5f88\u5bb9\u6613\u4ea7\u751f\u8010\u836f\u6027\uff0c\u4e00\u65e6\u8010\u836f\u53c8\u9677\u5165\u65e0\u836f\u53ef\u7528\u7684\u72b6\u6001\u3002<\/div>\n<div><\/div>\n<div>\u63a5\u4e0b\u6765\uff0c\u6211\u4eec\u770b\u52302017\u5e746\u6708\u7f8e\u56fdFDA\u6279\u51c6\u4e86\u8bfa\u534e\u7684\u7ec4\u5408\u7597\u6cd5\u7528\u4e8eBRAF V600E\u7a81\u53d8\u7684\u665a\u671fNSCLC\u7684\u9002\u5e94\u75c7\u3002FDA\u4e0e\u6b64\u540c\u65f6\u6279\u51c6\u4e86Ion Torrent PGM 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Panel\uff0c\u7528\u4e8e\u80a0\u764c\u60a3\u8005\u4f7f\u7528\u5e15\u5c3c\u5355\u6297\u524dKRAS\u548cNRAS\u57fa\u56e0\u70ed\u70b9\u7a81\u53d8\u7684\u68c0\u6d4b\u3002<\/div>\n<div><\/div>\n<div>\u800c\u9776\u5411\u836f\u7269\u771f\u7684\u6709\u9650\u5417\uff1fALK\u878d\u5408\u5728NSCLC\u60a3\u8005\u4e2d\u5360\u6bd4\u4ec55%\u5de6\u53f3\uff0c\u5374\u67094\u4e2a\u836f\u7269\u4e0a\u5e02\uff0c\u591a\u4e2a\u836f\u7269\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u3002BRCA\u9633\u6027\u7684\u5375\u5de2\u764c\u60a3\u8005\u5360\u6bd4\u7ea625%\uff0c\u76ee\u524d\u5df2\u6709\u4e09\u4e2aPARP\u6291\u5236\u5242\u4e0a\u5e02\u2026\u2026\u8fd9\u4e0d\u662f\u76f2\u76ee\u4e50\u89c2\uff0c\u4f46\u4e00\u5207\u90fd\u5728\u524d\u8fdb\uff0c\u5305\u62ec\u671f\u671b\u4ece\u672c\u8d28\u4e0a\u514b\u670d\u80bf\u7624\u9003\u9038\u673a\u5236\u7684\u514d\u75ab\u7597\u6cd5\u3002<\/div>\n<div><\/div>\n<div>\u4eca\u5929\uff0c\u7f8e\u56fdFDA\u5ba3\u5e03\u6279\u51c6\u7eaa\u5ff5\u65af\u9686\u00b7\u51ef\u7279\u7433\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3\uff08MSK\uff09\u57fa\u4e8e\u4e8c\u4ee3\u6d4b\u5e8f\u6280\u672f\u7684\u764c\u75c7\u57fa\u56e0\u68c0\u6d4b\u5206\u6790\u5e73\u53f0MSK-IMPACT\u2122\u3002\u6240\u6709\u4e1a\u5185\u4eba\u58eb\u8f6c\u53d1\u7684\u65f6\u5019\u90fd\u5fcd\u4e0d\u4f4f\u8bf4\u201c\u5927\u52bf\u6240\u8d8b\u201d\uff0c\u8fd9\u4e00\u5e74\u6765FDA\u5df2\u7ecf\u7ed9\u4e86\u6211\u4eec\u592a\u591a\u7684\u60ca\u559c\uff0c\u8fd9\u4e00\u6b21\u6211\u53cd\u800c\u4e0d\u90a3\u4e48\u60ca\u559c\uff0c\u56e0\u4e3a\u8fd9\u662f\u4e34\u5e8a\u9700\u6c42\u3001\u662f\u5fc5\u7136\u65b9\u5411\u3002MSK\u80fd\u505a\u5230\u8fd9\u4e00\u6b65\u9760\u7684\u662f\u4e0d\u53ea\u662f\u4e00\u4e2a\u68c0\u6d4b\u6280\u672f\uff0c\u66f4\u662f\u80bf\u7624\u5927\u6570\u636e\u7684\u79ef\u7d2f\uff0c\u4eca\u5e745\u6708MSK\u5728Nature 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class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYqj8ZibPVq9ENul6ianYl3csdmSyqZKO2eaYzCibtBFTIFhxDgiaBUKKibwg.jpeg\" alt=\"RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYqj8ZibPVq9ENul6ianYl3csdmSyqZKO2eaYzCibtBFTIFhxDgiaBUKKibwg\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u91d1\u9e3d<\/div>\n\n<div style=\"text-align: center;\">\u00a0\u8a89\u8861\u57fa\u56e0 CEO\u00a0\u00a0\u00a0<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYjibGnPBxG38GpPJGWfTibsQfXKuib2l0hffaITc8ibYbk2bul7siaZZ0u1A.png\" alt=\"RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYjibGnPBxG38GpPJGWfTibsQfXKuib2l0hffaITc8ibYbk2bul7siaZZ0u1A\"\/><\/figure><\/div>\n\n<\/div>\n<div><\/div>\n<div>\u201cMSK\u5f00\u53d1\u7684\u57fa\u4e8eNGS\u5e73\u53f0\u7684468\u4e2a\u57fa\u56e0\u68c0\u6d4b\u4ea7\u54c1\uff0c\u5f97\u5230FDA\u6279\u51c6\u662fNGS\u6280\u672f\u5e73\u53f0\u5728\u4e34\u5e8a\u6bb5\u8de8\u8d8a\u6027\u7684\u4e8b\u4ef6\u3002\u5176\u7ed3\u679c\u4e2dMSI\uff08\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\uff09\u7684\u7a81\u53d8\u60c5\u51b5\uff0c\u8868\u660e\u8fd9\u4e9b\u60a3\u8005\u66f4\u53ef\u80fd\u5bf9\u514d\u75ab\u6cbb\u7597\u53d1\u751f\u53cd\u5e94\uff0c\u8fd9\u4e0e\u4eca\u5e745\u6708FDA\u6279\u51c6Keytruda\u7528\u4e8e\u6cbb\u7597MSI-H\u6216dMMR\u7684\u5b9e\u4f53\u7624\u60a3\u8005\u76f8\u5f97\u76ca\u5f70\uff0c\u800c\u4e14\u7a81\u7834\u4e86\u6bdb\u7ec6\u7ba1\u7535\u6cf3\u7684\u65b9\u6cd5\uff0c\u662f\u653f\u7b56\u3001\u4e34\u5e8a\u3001\u6280\u672f\u548c\u6570\u636e\u8f6c\u5316\u9636\u6bb5\u7684\u6210\u679c\u3002\u8fd9\u4e0e\u6211\u4eec\u8a89\u8861\u57fa\u56e0\u7684620\u7cbe\u51c6\u514d\u75abpanel\u5168\u65b9\u4f4d\u5206\u6790\u514d\u75ab\u836f\u7269\u3001\u9776\u5411\u836f\u7269\u548c\u5316\u7597\u836f\u7269\u7597\u6548\u7684\u5185\u5bb9\u4e5f\u7279\u522b\u5951\u5408\uff01\u201d<\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYDb15ibibj6QVeUysEPw3ZiaeNHj5hKTlH6lvGibkic7oUJxeCE2tzVv7OKA.jpeg\" alt=\"RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYDb15ibibj6QVeUysEPw3ZiaeNHj5hKTlH6lvGibkic7oUJxeCE2tzVv7OKA\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u738b\u51ef<\/div>\n\n<div style=\"text-align: center;\">\u00a0\u81f3\u672c\u533b\u7597\u521b\u59cb\u4eba\u517cCEO \u00a0<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYjibGnPBxG38GpPJGWfTibsQfXKuib2l0hffaITc8ibYbk2bul7siaZZ0u1A.png\" alt=\"RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYjibGnPBxG38GpPJGWfTibsQfXKuib2l0hffaITc8ibYbk2bul7siaZZ0u1A\"\/><\/figure><\/div>\n\n<\/div>\n<div><\/div>\n<div>\u201cFDA\u548c\u7f8e\u56fdNGS\u4e34\u5e8a\u68c0\u6d4b\u9f99\u5934\u4f01\u4e1a\u6700\u521d\u662f\u4ece2014\u5e74\u5c31\u5f00\u59cb\u6709\u63a5\u89e6\u3002\u52a8\u56e0\u662f\u5927\u5bb6\u90fd\u770b\u5230NGS\u591a\u57fa\u56e0\u7684\u5168\u9762\u68c0\u6d4b\u5728\u4e34\u5e8a\u4e0a\u5e26\u6765\u5f88\u5b9e\u6548\u7684\u5e94\u7528\uff0c\u548c\u72ec\u7279\u7684\u4e0d\u53ef\u66ff\u4ee3\u7684\u4f18\u52bf\u3002FDA\u5bf9MSK\u7684\u591a\u57fa\u56e0\u68c0\u6d4b\u7684\u6388\u6743\u4e5f\u662f\u5efa\u7acb\u5728\u8fc7\u53bb\u51e0\u5e74\u4e2dFDA\u5728\u9010\u6e10\u7684\u8d8a\u6765\u8d8a\u8be6\u7ec6\u7684\u4e86\u89e3NGS\u6280\u672f\u5728\u4e34\u5e8a\u7684\u5e94\u7528\u548c\u7ec6\u8282\uff0c\u540c\u65f6\u5305\u62ec\u4e1a\u5185\u7684\u9ad8\u8d28\u91cf\u6807\u6746\u4f01\u4e1a\u548c\u533b\u9662\u7684\u7ecf\u9a8c\u5206\u4eab\u3002\u5927\u5bb6\u5728\u5171\u540c\u7684\u66f4\u5feb\u7684\u63a8\u52a8\u6574\u4e2a\u884c\u4e1a\u7684\u5065\u5eb7\u53d1\u5c55\uff0c\u6700\u7ec8\u76ee\u7684\u662f\u4e3a\u4e86\u66f4\u597d\u7684\u53ca\u65f6\u7684\u5e2e\u52a9\u5230\u5e7f\u5927\u764c\u75c7\u60a3\u8005\u3002<\/div>\n<div><\/div>\n<div>\u4eca\u5929MSK\u7684\u83b7\u6279\u53ea\u662fFDA\u7684\u4e00\u4e2a\u7c7b\u522b\u7684\u5ba1\u6279\uff0c\u867d\u7136\u8fd8\u53ea\u662f\u4e00\u4e2a\u5f00\u59cb\uff0c\u4f46\u7684\u786e\u4ece\u7406\u5ff5\u4e0a\u5df2\u7ecf\u5e26\u6765\u4e86\u5de8\u5927\u7684\u53d8\u9769\u548c\u4e34\u5e8a\u68c0\u6d4b\u65b9\u5411\u7684\u6307\u5f15\u3002\u884c\u4e1a\u7684\u5ba1\u6279\u4ee5\u540e\u8d8a\u6765\u8d8a\u6ce8\u91cd\u4e8e\u5b9e\u6548\u6027\uff0c\u5e76\u7b80\u5316\u5ba1\u6279\u6d41\u7a0b\uff0c\u5171\u540c\u79ef\u6781\u63a8\u52a8\u3002\u5728NGS\u7684\u4e34\u5e8a\u68c0\u6d4b\u9886\u57df\uff0c\u8fd8\u6709\u66f4\u591a\u66f4\u597d\u7684\u5728\u540e\u9762\uff0c\u76f8\u4fe1FDA\u548c\u4e16\u754c\u8303\u56f4\u5185\u7684\u76d1\u7ba1\u673a\u6784\u4f1a\u6709\u7740\u66f4\u52a0\u9769\u65b0\u6027\u7684\u5ba1\u6279\u548c\u652f\u6301\u4f1a\u7ee7\u7eed\u51fa\u53f0\u3002 \u201d<\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYqR1ZicyGEII6e8lAkZKaWJ24hPTKDdLvEk2d6dWGVcRsnqGrlbmVH3g.jpeg\" alt=\"RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYqR1ZicyGEII6e8lAkZKaWJ24hPTKDdLvEk2d6dWGVcRsnqGrlbmVH3g\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u6234\u73e9<\/div>\n\n<div style=\"text-align: center;\">\u00a0\u4e2d\u79d1\u666e\u745eCTO\u00a0 \u00a0<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYjibGnPBxG38GpPJGWfTibsQfXKuib2l0hffaITc8ibYbk2bul7siaZZ0u1A.png\" alt=\"RmFicvQBAkgAf3ias9MI3yjQ7v79XazKKYjibGnPBxG38GpPJGWfTibsQfXKuib2l0hffaITc8ibYbk2bul7siaZZ0u1A\"\/><\/figure><\/div>\n\n<\/div>\n<div><\/div>\n<div>\u201cFDA \u6279\u51c6MSK-IMPACT 468 \u57fa\u56e0\u68c0\u6d4b\u5206\u6790\u5e73\u53f0\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u4e8b\u4ef6\uff0c\u4ee3\u8868\u7740\u5206\u5b50\u8bca\u65ad\u4ece\u5355\u7a81\u53d8\uff0c\u5355\u57fa\u56e0\u7684\u8bca\u65ad\u5411\u591a\u57fa\u56e0\u3001\u5927Panel\u3001\u5927\u6570\u636e\u3001\u5e73\u53f0\u5316\u7684\u6539\u53d8\u3002\u4ece\u957f\u8fdc\u6765\u770b\u4e3a\u4e34\u5e8a\u533b\u751f\u63d0\u4f9b\u4e86\u5168\u65b9\u4f4d\u7684\u9057\u4f20\u4fe1\u606f\uff0c\u5e2e\u52a9\u533b\u751f\u66f4\u7cbe\u51c6\u5730\u7ed9\u75c5\u4eba\u9009\u62e9\u6cbb\u7597\uff0c\u540c\u65f6\u4e5f\u6709\u6548\u7387\u5730\u7d2f\u79ef\u4e86\u5927\u91cf\u7814\u7a76\u6570\u636e\u3002FDA\u628a\u5927Panel\u5b9a\u4e49\u4e3a\u4e8c\u7c7b\u901a\u9053\uff0c\u5c06\u6765\u8fd9\u4e9b\u7c7b\u4f3c\u4ea7\u54c1\u4f1a\u8d70510(k)\u7684\u5ba1\u6279\u3002 \u4e2d\u79d1\u666e\u745e\u7684\u5927Panel\u4ea7\u54c1\u80fd\u540c\u65f6\u68c0\u6d4b409\u4e2a\u57fa\u56e0\uff0c\u6db5\u76d6\u8fd9\u4e9b\u57fa\u56e0\u4e0a\u7684\u7a81\u53d8\u3001\u62f7\u8d1d\u6570\u53d8\u5316\u3001\u548c\u57fa\u56e0\u91cd\u6392\u5e76\u5305\u542b\u4e0e\u514d\u75ab\u6cbb\u7597\u76f8\u5173\u7684MSI\uff0cTMB\u7b49\uff0c\u4e0e\u6b64\u601d\u8def\u4e0d\u8c0b\u800c\u5408\u3002\u201d<\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<div>\u53c2\u8003\u6587\u732e\uff1a<\/div>\n<div><\/div>\n<div>1.https:\/\/www.accessdata.fda.gov\/cdrh_docs\/reviews\/den170058.pdf<\/div>\n<div>2.https:\/\/www.mskcc.org\/blog\/fda-authorizes-msk-impact-test-analyzing-patient-tumors?from=timeline&amp;isappinstalled=0<\/div>\n<div>3.\u00a0www.fda.gov<\/div>\n<div><\/div>\n<div><\/div>\n<div>\u7f16\u8005\uff1a\u5e03\u4e09\u5c11\u00a0 |\u00a0 \u6821\u5bf9\uff1a\u8292\u679c\uff0c\u5c18\u7070\u00a0 \u00a0|\u00a0 \u5ba1\u6838\uff1a\u5341\u4e00\u90ce<\/div>\n<div><\/div>\n<div><\/div>\n<div>&#8212;&#8212;&#8211; \u6b63\u6587\u5b8c\u00a0&#8212;&#8212;&#8211;<\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<div>\u60a8\u53ef\u80fd\u8fd8\u4f1a\u611f\u5174\u8da3\u7684<\/div>\n<div><\/div>\n<div>\u00a0\u4e34\u5e8a\u4e13\u5bb6\u00a0\u00a0\u00a0\u00a0<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651632873&amp;idx=1&amp;sn=19e92002f553afc96c1ded128a2382db&amp;chksm=f37194d0c4061dc61ee99b1895c0585eced69c1cadd90c82795f6b4349bafcd6d0cb83840567&amp;scene=21#wechat_redirect\" \/>\u4e01\u6d01<\/a>\u00a0\u00a0\u00a0|\u00a0\u00a0<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651633639&amp;idx=4&amp;sn=a3b0a9ac4e83dcc45e0340490185f577&amp;chksm=f37197dec4061ec8275df131355b64038e9eadd1320b265d7fa160e01b9a254e01a69283969f&amp;scene=21#wechat_redirect\" \/>\u9ec4\u56fd\u82f1<\/a>\u00a0\u00a0\u00a0|\u00a0\u00a0<a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651633791&amp;idx=1&amp;sn=f0a94d167ccf90ff6b855e245c3ad198&amp;chksm=f3719846c4061150a2e8226e3d75813d2d721bca44b3ed066defd7c64462f4db49cd1db05809&amp;mpshare=1&amp;scene=1&amp;srcid=0929EO12hIs18jGDjhCyXtC9&amp;pass_ticket=bF4t%2F%2B0h1PHSHlJgGcNNVY1siKMQ1d5oslTwQr%2F7WvjK3VikZ1cSaYDo%2F%2Bt6VY1i#rd\" \/>\u6881\u519b<\/a>\u00a0\u00a0\u00a0|\u00a0\u00a0<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651632688&amp;idx=1&amp;sn=e389e9621a4f7c186ae3c8312b43d2b7&amp;chksm=f3719409c4061d1f3fd4a64a2cdd6f4977f353fc50f3f5bf9d7cf20f865819948f1a5a68ef3f&amp;scene=21#wechat_redirect\" \/>\u9ec4\u5c1a\u5fd7<\/a>\u00a0\u00a0\u00a0|\u00a0\u00a0<a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651632706&amp;idx=1&amp;sn=3076c4928b43b47c09c110d3a0f92cbc&amp;chksm=f371947bc4061d6dc21fc1a4140ae32ae86f3069c42d602b96c0e7155558c45215c3b036833b&amp;mpshare=1&amp;scene=1&amp;srcid=1009G9pv6gkHtIT4YA6bUG0v&amp;pass_ticket=2xEQHVt5%2B9wA5l0PeGKukqGiF5p5PIMoZQ3Hm%2FEEwH%2FASUn2CGKwO6oLZWtlQyTr#rd\" \/>\u987e\u5927\u592b<\/a>\u00a0\u00a0\u00a0|\u00a0\u00a0<a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247484571&amp;idx=1&amp;sn=c6ba4408eb9ac1f63e1fa4375b9d4ccc&amp;chksm=eb72b62cdc053f3a43c394fea0fc90e0579a263fa509b578ab01d20b376e22f76adf20cf90c7&amp;mpshare=1&amp;scene=1&amp;srcid=0610fTx4VnuZ6YL6KSX9W2f3&amp;pass_ticket=dBXlD6ied%2FmPJJ3Nn0ETpaxwGTKHEm%2FkVpvb3UeTuDUe3u22c7lVTea4ZITIWE%2F%2F#rd\" \/>\u9646\u56fd\u8f89 \u738b\u82e5\u5149 \u5f20\u5b66<\/a>\u00a0\u00a0\u00a0|\u00a0\u00a0<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651633045&amp;idx=1&amp;sn=77b39caaad9e5c2fadaadfd8ccc3a313&amp;chksm=f37195acc4061cba17342d5433e0cc7f75b16ec42d9db4413083885b73510ada616bb99c405f&amp;scene=21#wechat_redirect\" \/>\u6c88\u4ea6\u5e73<\/a>\u00a0\u00a0\u00a0\u00a0|\u00a0\u00a0<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651633217&amp;idx=1&amp;sn=80cb4cf09c37289196ef472bd2183ef4&amp;chksm=f3719678c4061f6eb925e35850d45b0162fdc99ec0e61d0c844a67acdeea9c072a232fc111b6&amp;scene=21#wechat_redirect\" \/>\u674e\u5b81<\/a>\u00a0\u00a0\u00a0|\u00a0\u00a0\u00a0<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651633425&amp;idx=1&amp;sn=c03a5556ac543883f9109a42e9e1a567&amp;chksm=f3719728c4061e3eb356d922115f3ea29d40e90cd8c5da2f7c081ca19967db3e75181fc32bb4&amp;scene=21#wechat_redirect\" \/>\u6768\u4e91\u751f<\/a>\u00a0\u00a0\u00a0|\u00a0\u00a0<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651632839&amp;idx=1&amp;sn=452c1f25f3bbb4bd087afe9221e14a07&amp;chksm=f37194fec4061de832d5b3d03c2ba7ef27538aee4375909672223f0a6bc3ac0b8515691855ba&amp;scene=21#wechat_redirect\" \/>\u7941\u9e23<\/a>\u00a0\u00a0\u00a0\u00a0|\u00a0\u00a0<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651632826&amp;idx=1&amp;sn=26ac7d04cec86878f3072559af679c3a&amp;chksm=f3719483c4061d95f3c96b4b60235c27e1eee38de1f0552dc6bc53b1dd714570efc28e6fba4c&amp;scene=21#wechat_redirect\" \/>\u738b\u827a<\/a>\u00a0\u00a0\u00a0\u00a0|\u00a0\u00a0<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651633066&amp;idx=1&amp;sn=381de9a0e18d1355eb0528e82b7a973a&amp;chksm=f3719593c4061c855999d3b8c1155944e234c0852fe8c8734b69c320a3f6be1cdd17192ca15f&amp;scene=21#wechat_redirect\" \/>\u6881\u5fd7\u6e05<\/a>\u00a0\u00a0\u00a0|\u00a0\u00a0<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651630391&amp;idx=1&amp;sn=f2066a9ad96575432152d278641ec9db&amp;scene=21#wechat_redirect\" \/>\u738b\u5a01<\/a>\u00a0\u00a0\u00a0|\u00a0\u00a0<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651632388&amp;idx=2&amp;sn=dab6af4218065042f50a33543d912a78&amp;chksm=f371933dc4061a2bbc26d6d486f757a0b438cab2ceb866953ef1654325fa70648a6729ce89f0&amp;scene=21#wechat_redirect\" \/>\u738b\u5955\u9e25<\/a>\u00a0\u00a0\u00a0 \u00a0\u00a0\u79d1\u7814\u5927\u5496\u00a0\u00a0\u00a0 \u00a0\u00a0<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651632110&amp;idx=2&amp;sn=323a4b51edc8c2f182761a2fc9367f84&amp;chksm=f37191d7c40618c142f6f59ad7cde7aafbdb6543006154cc372381693b8918413abae9882acc&amp;scene=21#wechat_redirect\" \/>\u9ad8\u798f<\/a>\u00a0\u00a0\u00a0|\u00a0\u00a0<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651633639&amp;idx=2&amp;sn=b715c9e25d1108fce16fb74d2149278d&amp;chksm=f37197dec4061ec843b609f3cfc54734bf8b0588ebc6551c71ef21967c00476fc39d6b46e5b1&amp;scene=21#wechat_redirect\" \/>\u9b4f\u4e8e\u5168<\/a>\u00a0\u00a0\u00a0|\u00a0\u00a0\u00a0<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651631360&amp;idx=1&amp;sn=565036596d835ba9052f0108eee78542&amp;chksm=f3718f39c406062f3c75a809dec4614d1bee94ae2692430fa314ff809fa3e21fd32218bbe0a7&amp;scene=21#wechat_redirect\" \/>\u674e\u7ee7\u627f<\/a>\u00a0\u00a0\u00a0|\u00a0\u00a0<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651633394&amp;idx=1&amp;sn=005dd93c3869495a8bf7977c3fc68ff4&amp;chksm=f37196cbc4061fdd4c10b0196ac8a1af2b231baa3887b3f2d6e4efea385bcb1714d4e0e511b6&amp;scene=21#wechat_redirect\" \/>\u6768\u745e\u99a5<\/a>\u00a0\u00a0\u00a0|\u00a0\u00a0<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651633639&amp;idx=3&amp;sn=e805aa2fe55d2e0fb6019a50262ec60f&amp;chksm=f37197dec4061ec826911c25c8ceb7eb4159b9c45fa8989251a41cbb0f1ed03eac5b7aac5bbf&amp;scene=21#wechat_redirect\" \/>\u65b9\u5411\u4e1c<\/a>\u00a0\u00a0\u00a0|\u00a0\u00a0\u00a0<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651633167&amp;idx=1&amp;sn=5abf7e085908ee331ef8569cfd559006&amp;chksm=f3719636c4061f20ba90745b5785507b365166f0b8fe2fc7bdb7373b926f66b4deae8e3a7b11&amp;scene=21#wechat_redirect\" \/>\u9a6c\u7aef<\/a>\u00a0\u00a0\u00a0|\u00a0 \u00a0\u00a0<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651633024&amp;idx=1&amp;sn=41311a675524802be40cbd542402a97b&amp;chksm=f37195b9c4061cafbc44f5d40a0e915590ce33eff86a23759c6a537c173364714d6fb7cfe81a&amp;scene=21#wechat_redirect\" \/>\u65bd\u5947\u60e0<\/a>\u00a0\u00a0\u00a0|\u00a0\u00a0<a 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href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651632509&amp;idx=1&amp;sn=0b208aad5ae0503b0b307fc14c1bf0bc&amp;chksm=f3719344c4061a5296c5f017a6dd311d06b3ae3d34157db305024a4681f261737317591cc190&amp;scene=21#wechat_redirect\" \/>\u960e\u6d77<\/a>\u00a0\u00a0\u00a0|\u00a0\u00a0<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651632432&amp;idx=1&amp;sn=2ef7b27ced3ffb136a0fcbded3591821&amp;chksm=f3719309c4061a1ff043b67f6204dab60b6aa37f939f521019fa690982edef0486a9c1eb7595&amp;scene=21#wechat_redirect\" \/>\u718a\u78ca<\/a>\u00a0\u00a0\u00a0\u00a0|\u00a0\u00a0\u00a0<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651632671&amp;idx=1&amp;sn=81a1d76cc4f2b322a6fccf1d8fbc5543&amp;chksm=f3719426c4061d3059e80b7e914646c63fbd44846c4f4f94f79166d1e5293723eb8cf6a68747&amp;scene=21#wechat_redirect\" \/>\u6768\u4e91\u971e<\/a>\u00a0\u00a0\u00a0\u00a0|\u00a0\u00a0<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651632500&amp;idx=1&amp;sn=80865ec00f8449ed9ef0664325bc5274&amp;chksm=f371934dc4061a5b887cad0ff1192643e2eeb366228c6a60ac11d7f15ae5aa2115f149cb979a&amp;scene=21#wechat_redirect\" \/>\u5f20\u4e91\u9e4f<\/a>\u00a0\u00a0\u00a0|\u00a0\u00a0<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651632441&amp;idx=1&amp;sn=924ff49a35c669245f3fecaa2735bc00&amp;chksm=f3719300c4061a16213c458ca28f46fed042410f504b0137450869a0d65ac21559f21f174241&amp;scene=21#wechat_redirect\" \/>\u67f4\u6620\u723d<\/a>\u00a0\u00a0\u00a0 \u00a0|\u00a0\u00a0\u00a0<a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651633533&amp;idx=1&amp;sn=29da4ecf825779172bc1ea8b409448a8&amp;chksm=f3719744c4061e5282744c19cb1b9ab6651502c2cb8147c28e064af9db910db010425096979b&amp;mpshare=1&amp;scene=21&amp;srcid=071937xFB607pzT3Xl94gE8f&amp;pass_ticket=AYnY0FxoZ5vTvVfmVpPDsaCi7wWU2yaWsGWbcuTbkmn2wxp99vcIiL2w8pyOL263#wechat_redirect\" \/>\u8d3a\u5efa\u594e<\/a>\u00a0\u00a0\u00a0|\u00a0\u00a0\u00a0<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651632522&amp;idx=1&amp;sn=7a868a53c9fb8430bcd1a91eec4c8be0&amp;chksm=f37193b3c4061aa5722401f43c073b744aa9939904ba0610bc5325f54b881a5cf8332dc64692&amp;scene=21#wechat_redirect\" \/>\u79e6\u6960<\/a>\u00a0\u00a0\u00a0\u00a0|\u00a0\u00a0\u00a0<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651633554&amp;idx=1&amp;sn=7ed45973d31a31db1c9647f9381b01fc&amp;chksm=f37197abc4061ebdbafc2fb8a17834368bbb8a3aa9a65d3e185bb094a9f7d6340aa6c1361df9&amp;scene=21#wechat_redirect\" 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