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\u5173\u952e\u5b57\uff1a\u80bf\u7624\u7cbe\u51c6\u533b\u7597 TMB MSI<\/div>\n
\u56fd\u5185\u9996\u6b3e\u514d\u75ab\u836f\u7269\u7597\u6548\u8bc4\u4f30ctDNA panel<\/div>\n
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2017\u5e74\u672b\uff0c\u56fd\u4ea7\u514d\u75ab\u6cbb\u7597\u836f\u7269\u83b7\u5f97\u7a81\u7834\u8fdb\u5c55\uff0c12\u6708\uff0c\u9996\u4e2a\u56fd\u4ea7CAR-T\u7597\u6cd5\u548c\u56fd\u4ea7PD-1\u5355\u6297\u5206\u522b\u83b7\u5f97CFDA\u548cCDE\u53d7\u7406\uff0c\u67d0\u533b\u836f\u516c\u53f8\u7684PD-L1\u5355\u6297\u88abCFDA\u6279\u51c6\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u67d0\u836f\u7269CRO\u4f01\u4e1a\u7684PD-L1\u514d\u75ab\u8bd5\u5242\u76d2\u53d1\u5e03\u3002\u56fd\u9645\u5e02\u573a\u5df2\u6709Ipilimumab\uff0cNivolumab\u7b49 6\u5927\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u836f\u7269\u4e0a\u5e02\u3002\u5728\u9009\u62e9\u4f7f\u7528\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u836f\u7269\u65f6\uff0c\u5982\u4f55\u5bf9\u836f\u7269\u7597\u6548\u8fdb\u884c\u51c6\u786e\u8bc4\u4f30\u662f\u4e00\u76f4\u4ee5\u6765\u7684\u96be\u9898\u3002\u4e13\u6ce8\u4e8e\u80bf\u7624\u7cbe\u51c6\u514d\u75ab\u6cbb\u7597\u7684\u8a89\u8861\u57fa\u56e0\uff0c\u5f00\u53d1\u51fa\u56fd\u5185\u7b2c\u4e00\u6b3e\u8bc4\u4ef7\u514d\u75ab\u836f\u7269\u7597\u6548\u7684 ctDNA panel\uff0c\u4ee5\u201c\u514d\u75ab\u836f\u7269\u6cbb\u7597\u7684\u6700\u4f73\u4f19\u4f34\u201d\u4e3a\u5b9a\u4f4d\uff0c\u7387\u5148\u6380\u5f00\u4e86\u8fd9\u4e2a\u95ee\u9898\u7684\u7b54\u6848\u3002<\/div>\n
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\"RmFicvQBAkgAlGbnCiawv7dMAPIZRpyhJoNxpLFH0C7d6HPdXKqnv9g1fFk11E01HmiaViasicoFRkEtGM6Yu5HCRLA\"\/<\/figure><\/div>\n\n
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\"RmFicvQBAkgAlGbnCiawv7dMAPIZRpyhJoOL15WY0PdWc7CxQB0MjYAtZfHYy3I1Cg7DFkia9MIOMxGiaMMEXqNsDA\"\/<\/figure><\/div>\n\n
\u56fe3\uff1a\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u9776\u6807<\/div>\n
\u4ee5Nivolumab\u7684\u4e09\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e3a\u4f8b\uff08\u56fe4\uff09\uff0c\u9ad8\u7a81\u53d8\u8d1f\u8377\u7ec4\u63a5\u53d7Nivolumab\u6cbb\u7597\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u65f6\u95f4\uff08PFS\uff09\u4e3a10.8\u4e2a\u6708\uff0c\u8fdc\u597d\u4e8e\u6807\u51c6\u5316\u7597\u76846.9\u4e2a\u6708\uff0c\u800c\u4e2d\u4f4e\u7a81\u53d8\u8d1f\u8377\u7ec4\u63a5\u53d7Nivolumab\u4ec5\u4e3a3.5\u4e2a\u6708\uff0c\u751a\u81f3\u6bd4\u6807\u51c6\u5316\u7597\u7565\u5dee\u3002<\/div>\n\n
\n
\"RmFicvQBAkgAlGbnCiawv7dMAPIZRpyhJo8HUd78j9aNT0icUnibE5Nk6owaqprdsKO4ibBRktnHRXFic0eCRicKn85rA\"\/<\/figure><\/div>\n\n
\u56fe4 \u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08TMB\uff09\u5bf9\u836f\u7269Nivolumab\u7597\u6548\u7684\u5f71\u54cd\uff0c\u8a89\u8861\u57fa\u56e0\u4f9b\u56fe<\/div>\n
\u5728\u7f8e\u56fd\uff0c\u57fa\u4e8eNGS\uff08\u9ad8\u901a\u91cf\u6d4b\u5e8f\uff09\u7684\u5206\u5b50\u68c0\u6d4bPanel\uff08\u7ec4\u5408\uff09\u662f\u7684LDT\uff08\u5b9e\u9a8c\u5ba4\u7814\u53d1\u7684\u68c0\u6d4b\uff09\u9646\u7eed\u53d7\u5230FDA\u7684\u6279\u51c6\uff0c\u5bf9\u4e8eTMB\uff0cMSI\u5728\u5185\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8fdb\u884c\u4f53\u5916\u68c0\u6d4b\u3002\u57fa\u56e0\u6167\u6574\u7406\u5982\u4e0b\u88681\uff1a<\/div>\n
\u00a0<\/div>\n
\u88681\uff1a\u57fa\u4e8e\u9ad8\u901a\u91cf\u6d4b\u5e8f\u7684\u80bf\u7624\u4f34\u968f\u8bca\u65ad\u57fa\u56e0Panel\u00a0<\/div>\n
\u673a\u6784<\/div>\n
Panel\u540d\u79f0<\/div>\n
\u9002\u5e94\u764c\u79cd<\/div>\n
\u76f8\u5173\u836f\u7269<\/div>\n
Foundation Medicine<\/div>\n
FoundationFocus\u2122 CDxBRCA<\/div>\n
\u5375\u5de2\u764c<\/div>\n
Rubraca<\/div>\n
Thermo Fisher<\/div>\n
Oncomine DX Target Test<\/div>\n
\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<\/div>\n
dabrafenib & trametinib\uff0ccrizotinib\uff0cgefitinib<\/div>\n
Illumina<\/div>\n
Extended RAS Panel<\/div>\n
\u7ed3\u76f4\u80a0\u764c<\/div>\n
Vectibix<\/div>\n
MSK<\/div>\n
MSK-IMPACT\uff08510k\uff09<\/div>\n
\u591a\u764c\u79cd<\/div>\n
\u591a\u836f\u7269<\/div>\n
Foundation Medicine<\/div>\n
FoundationOne CDx<\/div>\n
\u591a\u764c\u79cd<\/div>\n
\u591a\u836f\u7269<\/div>\n
\u56fd\u5185\u662f\u5426\u6709\u4e13\u6ce8\u8bc4\u4ef7\u514d\u75ab\u836f\u7269\u7597\u6548\u7684\u6210\u719fctDNA Panel\u5462\uff1f\u76ee\u524d\u591a\u5bb6\u4f01\u4e1a\u6b63\u5728\u7814\u53d1\u4e2d\u3002\u4e13\u6ce8\u4e8e\u80bf\u7624\u7cbe\u51c6\u514d\u75ab\u6cbb\u7597\u7684\u8a89\u8861\u57fa\u56e0\uff08\u8be6\u60c5\u70b9\u51fb<\/a>\uff09\uff0c\u5f00\u53d1\u51fa\u56fd\u5185\u9996\u6b3e\u8bc4\u4ef7\u514d\u75ab\u836f\u7269\u7597\u6548\u7684 ctDNA panel\uff0c\u4ee5\u201c\u514d\u75ab\u836f\u7269\u6cbb\u7597\u7684\u6700\u4f73\u4f19\u4f34\u201d\u4e3a\u5b9a\u4f4d\uff0c\u7387\u5148\u6380\u5f00\u4e86\u8fd9\u4e2a\u95ee\u9898\u7684\u7b54\u6848\u3002<\/div>\n
\u00a0<\/div>\n
5\u3001\u56fd\u5185\u9996\u6b3e\u8bc4\u4ef7\u514d\u75ab\u836f\u7269\u7597\u6548\u7684 ctDNA panel<\/div>\n
\u80bf\u7624\u57fa\u56e0\u68c0\u6d4b\u7684\u4ea7\u54c1\u7433\u7405\u6ee1\u76ee\uff0c\u4ee5\u80bf\u7624\u9057\u4f20\u98ce\u9669\u7684\u5065\u5eb7\u7ba1\u7406\u4ea7\u54c1\u5c45\u591a\u3002\u8fd9\u662f\u57fa\u56e0\u68c0\u6d4b\u5e02\u573a\u5728\u6210\u719f\u4e4b\u524d\u9ad8\u7aef\u6d88\u8d39\u4ea7\u54c1\u4e4b\u4e00\u3002\u4f46\u662f\uff0c\u8fd9\u79cd\u60c5\u5f62\u4e0b\uff0c\u80bf\u7624\u57fa\u56e0\u68c0\u6d4b\u4e3a\u9633\u6027\u540e\u7684\u53ef\u6cbb\u7597\u65b9\u6848\u6216\u8005\u8def\u5f84\u5f80\u5f80\u9700\u8981\u6253\u4e00\u4e2a\u95ee\u53f7\u3002\u7ed3\u5408\u4ee5\u4e0a\u80bf\u7624\u7cbe\u51c6\u514d\u75ab\u6cbb\u7597\u7684\u6280\u672f\u3001\u653f\u7b56\u548c\u540c\u7b49\u4ea7\u54c1\u6761\u4ef6\u4e0b\uff0c\u4e0e\u80bf\u7624\u4e2a\u4f53\u5316\u7528\u836f\u76f8\u5173\u7684\u57fa\u56e0\u68c0\u6d4b\u663e\u5f97\u5c24\u4e3a\u91cd\u8981\u3002<\/div>\n
\u00a0<\/div>\n
\u8a89\u8861\u57fa\u56e0\u201c\u80bf\u7624\u4e2a\u4f53\u5316\u8bca\u7597620\u57fa\u56e0\u68c0\u6d4b\u201d\u5728\u8fd9\u79cd\u60c5\u5f62\u4e0b\u7ecf\u8fc7\u4e24\u5e74\u7684\u7814\u53d1\uff0c\u5e94\u8fd0\u800c\u751f\u4e0a\u5e02\uff0c\u6210\u4e3a\u56fd\u5185\u9996\u6b3e\u8bc4\u4ef7\u514d\u75ab\u836f\u7269\u7597\u6548\u7684 ctDNA panel\u3002<\/div>\n
\u8a89\u8861\u57fa\u56e0\u7684\u6838\u5fc3\u7ba1\u7406\u56e2\u961f\u6765\u81eaThermoFisher\u3001\u534e\u5927\u57fa\u56e0\u3001\u5339\u5179\u5821\u5927\u5b66\u3001\u5317\u4eac\u5927\u5b66\u3001\u4e2d\u79d1\u9662\u7b49\u56fd\u5185\u5916\u4e00\u6d41\u9ad8\u6821\u53ca\u4f01\u4e1a\uff0c\u5728\u4eca\u5e7410\u6708\u63a8\u51fa\u201c\u4e07\u4eba\u80bf\u7624\u514d\u75ab\u65b9\u821f\u8ba1\u5212\u201d\uff08\u8be6\u60c5\u70b9\u51fb<\/a>\uff09\uff0c\u5b9a\u4f4d\u4e3a\u201c\u7cbe\u51c6\u80bf\u7624\u514d\u75ab\u8bca\u7597\u9886\u8dd1\u8005\u201d\uff0c\u5e2e\u52a9\u80bf\u7624\u533b\u751f\u548c\u60a3\u8005\u63d0\u4f9b\u80bf\u7624\u5927\u6570\u636e\u7684\u89e3\u51b3\u65b9\u6848\uff0c\u52a9\u529b\u65b0\u836f\u7814\u53d1\u3002<\/div>\n
\u53d6\u5916\u5468\u88408-10ml\u6216\u80bf\u7624\u7ec4\u7ec7\uff0c\u57fa\u4e8e\u76ee\u6807\u6355\u83b7\u7684\u9ad8\u901a\u91cf\u6d4b\u5e8f\uff0c\u5bf9\u514d\u75ab\u76f8\u5173\u57fa\u56e0\u3001\u9776\u5411\u836f\u76f8\u5173\u57fa\u56e0\u3001\u5316\u7597\u836f\u76f8\u5173\u57fa\u56e0\u7b49620\u4e2a\u57fa\u56e0\u68c0\u6d4b\uff0c\u7ecf\u8fc7\u751f\u7269\u4fe1\u606f\u5206\u6790\u548c\u4e13\u5bb6\u89e3\u8bfb\uff0c\u51fa\u5177\u62a5\u544a\u3002\uff08\u89c1\u88682\uff09<\/div>\n
\u00a0<\/div>\n
\u88682\uff1a \u80bf\u7624\u4e2a\u4f53\u5316\u8bca\u7597620\u57fa\u56e0\u68c0\u6d4b\u4ea7\u54c1\u5185\u5bb9<\/div>\n
\u7c7b\u522b<\/div>\n
\u6570\u76ee<\/div>\n
\u5185\u5bb9<\/div>\n
\u68c0\u6d4b\u57fa\u56e0\u6570<\/div>\n
19\u4e2a<\/div>\n
\u514d\u75ab\u7597\u6548\u76f8\u5173\u57fa\u56e0<\/div>\n
65\u4e2a<\/div>\n
DNA\u4fee\u590d\u76f8\u5173\u57fa\u56e0<\/div>\n
91\u4e2a<\/div>\n
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62\u4e2a<\/div>\n
\u9776\u5411\u836f\u7269\u5bc6\u5207\u76f8\u5173\u7684\u9776\u70b9\u57fa\u56e0<\/div>\n
23\u4e2a<\/div>\n
\u5316\u7597\u836f\u7269\u76f8\u5173\u57fa\u56e0<\/div>\n
61\u4e2a<\/div>\n
\u9057\u4f20\u6027\u80bf\u7624\u98ce\u9669 \u76f8\u5173\u57fa\u56e0<\/div>\n
\u89e3\u8bfb\u5185\u5bb9<\/div>\n
3\u79cd<\/div>\n
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120+\u79cd<\/div>\n
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26\u79cd<\/div>\n
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21\u79cd<\/div>\n
\u9057\u4f20\u6027\u80bf\u7624\u7684\u98ce\u9669<\/div>\n
\u8a89\u8861\u57fa\u56e0CTO\uff0c\u7814\u53d1\u8d1f\u8d23\u4eba\u8d75\u56fd\u680b\u535a\u58eb\uff08\u8be6\u60c5\u70b9\u51fb<\/a>\uff09\u8868\u793a\uff0c\u201c\u80bf\u7624\u4e2a\u4f53\u5316\u8bca\u7597620\u57fa\u56e0\u68c0\u6d4b\u201d\u4ea7\u54c1\u6db5\u76d6\u6700\u5168\u4e0e\u514d\u75ab\u6cbb\u7597\u76f8\u5173\u57fa\u56e0,\u5305\u62ec\u4e0e\u8010\u836f\u3001\u5feb\u901f\u8fdb\u5c55\u53ca DNA\u4fee\u590d\u7cfb\u7edf\u76f8\u5173\u57fa\u56e0\u3002\u9009\u7528Promega\u8bd5\u5242\u76d2\u5bf9\u7167\u68c0\u6d4bMSI\u4f4d\u70b9\uff0c\u53cc\u5e73\u53f0\u5e73\u884c\u68c0\u6d4b\u4e25\u683c\u6709\u6548\u9a8c\u8bc1\u3002TMB\u68c0\u6d4b\uff0c\u91c7\u75281000+\u4f8b\u4e34\u5e8a\u6837\u672cWES\u7684\u68c0\u6d4b\u7ed3\u679c\u9a8c\u8bc1\uff0c\u786e\u4fdd\u4e25\u9009\u3001\u4e25\u683c\u3001\u4e25\u8c28\u3002<\/div>\n
\u00a0<\/div>\n
\u88683\uff1a\u5e38\u89c1Panel\u5bf9\u514d\u75ab\u7597\u6548\u76f8\u5173\u57fa\u56e0\u7684\u68c0\u6d4b<\/div>\n\n
\n
\"RmFicvQBAkgAlGbnCiawv7dMAPIZRpyhJosqcV20g2qUKfS0FtVzicGGOsvZE0NBL9riasMEDU5ndoqiaM0vSrzH5qg\"\/<\/figure><\/div>\n\n<\/div>\n
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\"RmFicvQBAkgAlGbnCiawv7dMAPIZRpyhJoWX35nREEVqogamHgFUyXQOL78dgfkKwYJgbicCWjAkvic7DEIZicUTPXg\"\/<\/figure><\/div>\n\n
\u56fe5 WES\u8ddf620 Gene Panel\u7684\u4e00\u81f4\u6027<\/div>\n
\u201c\u80bf\u7624\u4e2a\u4f53\u5316\u8bca\u7597620\u57fa\u56e0\u68c0\u6d4b\u201d\u4ea7\u54c1\u5bf9\u4e8e\u9700\u8981\u5168\u9762\u7684\u514d\u75ab\u836f\u7269\u7597\u6548\u9884\u6d4b\u7684\u80bf\u7624\u60a3\u8005\uff0c\u8bc4\u4ef7\u514d\u75ab\u836f\u7269\u7597\u6548\uff0c\u68c0\u6d4b\u52a8\u6001\u76d1\u6d4b\u514d\u75ab\u7597\u6548\uff1b\u5bf9\u665a\u671f\u590d\u53d1\u8f6c\u79fb\u7684\u60a3\u8005\u5168\u9762\u6b63\u786e\u6307\u5bfc\u7528\u836f\u3001\u76d1\u6d4b\u7528\u836f\u8010\u836f\uff1b\u534f\u52a9\u836f\u5382\u505aI\/II\u671f\u80bf\u7624\u60a3\u8005\u7684\u5206\u5c42\u5206\u6790,\u534f\u52a9\u7b5b\u9009II\/III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4eba\u7fa4\u5165\u7ec4\u3002<\/div>\n
\u00a0<\/div>\n
\u4f5c\u4e3a\u56fd\u5185\u7b2c\u4e00\u6b3e\u8bc4\u4ef7\u514d\u75ab\u836f\u7269\u7597\u6548\u7684ctDNA panel\uff0c\u5728\u514d\u75ab\u836f\u7269\u56fd\u5185\u5c1a\u672a\u83b7\u6279\u7684\u65f6\u673a\uff0c\u4f5c\u4e3a\u6700\u65e9\u4e00\u6279\u5207\u5165\u4e34\u5e8a\u7684\u514d\u75ab\u4f34\u968f\u68c0\u6d4b\u4ea7\u54c1\u63d0\u524d\u9884\u70ed\u3002\u627e\u51c6\u884c\u4e1a\u9700\u6c42\u548c\u75db\u70b9\uff0c\u6df1\u8015\u6253\u78e8\u4ea7\u54c1\u3002\u671f\u5f85\u8a89\u8861\u57fa\u56e0\u7684\u4ea7\u54c1\u66f4\u591a\u8868\u73b0\uff0c\u4e3a\u80bf\u7624\u533b\u751f\u63d0\u4f9b\u57fa\u56e0\u68c0\u6d4b\u5229\u5668\uff0c\u4e3a\u80bf\u7624\u60a3\u8005\u9020\u798f\u3002<\/div>\n
\u00a0<\/div>\n
\u7f16\u540e\u8bb0<\/div>\n
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\u7f16\u8005\uff1aCindy\u00a0 \u00a0|\u00a0 \u6821\u5bf9\uff1aCandice\u00a0 \u00a0|\u00a0 \u5ba1\u6838\uff1a\u8292\u679c<\/div>\n\n
\n
\"RmFicvQBAkgDnic1wvB8FoQwHpw7g70E2SVjbsDzSfht7UDRia5Q6iciax9PofkezPCxialjm24IwepFC8atiaDuwu75A\"\/<\/figure><\/div>\n\n<\/div>\n
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\u76f8\u5173\u9605\u8bfb<\/div>\n
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