{"id":9778,"date":"2017-12-20T23:40:04","date_gmt":"2017-12-20T15:40:04","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&mid=100002859&idx=1&sn=6a4d75592d322859e9fbc8c2f4f79e0e&chksm=6b72be9c5c05378ac5ad54b8a10605f24ca88e5d4474979aee9ebadd3061e575b05fc3e361f5#rd"},"modified":"2026-04-09T09:35:33","modified_gmt":"2026-04-09T01:35:33","slug":"535549","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2017\/12\/20\/535549\/","title":{"rendered":"\u57fa\u56e0\u79d1\u6280\u5e74\u5ea6\u5341\u5927\u8fdb\u5c55\uff1a\u57fa\u56e0\u884c\u4e1a2017\u5e74\u5ea6\u76d8\u70b9\u3010\u6280\u672f\u7bc7\u3011"},"content":{"rendered":"

<\/p>\n

<\/div>\n
\n\n
\n
\"RmFicvQBAkgDEsUia5jbfibMgeRrNibH1ns0NaxVdCMqRl9Bcn0geKXKbn4CByInShB9u6lDPnKmK1nhKxqqiaRaUzQ\"\/<\/figure><\/div>\n\n<\/div>\n
\u5173\u952e\u5b57\uff1a\u5355\u7ec6\u80de\u7b5b\u67e5 \u67d3\u8272\u4f53\u5408\u6210\u836f\u7269\u57fa\u56e0\u7ec4<\/div>\n
\u5fae\u751f\u7269\u7ec4\u00a0\u6db2\u4f53\u6d3b\u68c0 \u514d\u75ab\u6cbb\u7597 \u57fa\u56e0\u7f16\u8f91<\/div>\n
\u5149\u9057\u4f20\u5b66 \u5408\u6210\u78b1\u57fa<\/div>\n
<\/div>\n
\u9605\u8bfb\u7528\u65f6\uff1a\u7ea66\u5206\u949f<\/div>\n
\u5bfc\u8bed<\/div>\n
\u7ee7\u57fa\u56e0\u6167\u53d1\u5e03\u57fa\u56e0\u884c\u4e1a2017\u5e74\u5ea6\u76d8\u70b9\u6295\u878d\u8d44\u7bc7\uff08\u8be6\u60c5<\/a>\uff09\u540e\uff0c\u6b64\u7bc7\u548c\u5927\u5bb6\u5206\u4eab\u5e74\u5ea6\u57fa\u56e0\u79d1\u6280\u5341\u5927\u8fdb\u5c55\u30022017\u5e74\u7a33\u5b9a\u5f00\u653e\u7684\u653f\u7b56\u548c\u8d44\u672c\u56de\u6696\u52a0\u901f\u4e86\u6280\u672f\u7814\u53d1\u548c\u8f6c\u5316\uff0c\u4ece\u79d1\u5b66\u53d1\u73b0\u3001\u6280\u672f\u7814\u53d1\u5230\u5e94\u7528\u62d3\u5c55\u7684\u751f\u6001\u73af\u5883\u5df2\u7ecf\u4ff1\u5907\uff0c\u5c55\u793a\u7740\u4ee5\u57fa\u56e0\u79d1\u6280\u4e3a\u6838\u5fc3\u7684\u6570\u5b57\u5065\u5eb7\u9886\u57df\u8fc8\u5165\u9ec4\u91d1\u5341\u5e74\u7684\u826f\u597d\u5f00\u7aef\u3002\u672c\u6587\u8be6\u7ec6\u7248\u672c\u5c06\u6574\u5408\u5230\u6587\u672b\u9884\u544a\u7684\u57fa\u56e0\u884c\u4e1a2017\u5e74\u5ea6\u62a5\u544a\u4e2d\u3002<\/div>\n
<\/div>\n
<\/div>\n
\n\n
\n
\"RmFicvQBAkgCAbF9eGxibicPNgfddTxg7hYZfZ6GXXA2FibJUScSicbWRpcj7nBGvPQ0DKUPcWo6Ec2VDjrR6yMBTGQ\"\/<\/figure><\/div>\n\n
\u5212\u91cd\u70b9<\/div>\n
\u5728\u5355\u7ec6\u80de\u6c34\u5e73\u8fdb\u884c\u9057\u4f20\u6027\u75be\u75c5\u7b5b\u67e5<\/div>\n
\u4eba\u5de5\u5408\u6210\u5b8c\u6574\u6d3b\u6027\u67d3\u8272\u4f53<\/div>\n
\u9996\u4e2a\u57fa\u4e8e\u80bf\u7624\u751f\u7269\u6807\u5fd7\u7269\uff0c\u800c\u4e0d\u8003\u8651\u80bf\u7624\u6765\u6e90\u7684\u836f\u7269<\/div>\n
\u53d1\u73b0\u6291\u5236\u80a5\u80d6\u7684\u80a0\u9053\u5fae\u751f\u7269<\/div>\n
\u901a\u8fc7\u6db2\u4f53\u6d3b\u68c0\u7b5b\u67e5\u6ca1\u6709\u75c7\u72b6\u7684\u65e9\u671f\u9f3b\u54bd\u764c<\/div>\n
\u5168\u7403\u9996\u4e2a\u80bf\u7624\u514d\u75ab\u6cbb\u7597CRA-T\u7597\u6cd5\u83b7\u6279\u4e0a\u5e02<\/div>\n
\u5408\u6210\u201c\u57fa\u56e0\u7535\u8def\u201d\u7cbe\u51c6\u6fc0\u6d3b\u6297\u764c\u7ec6\u80de\u7684\u514d\u75ab\u7cfb\u7edf<\/div>\n
\u57fa\u56e0\u7f16\u8f91\u8fdb\u5165\u5355\u78b1\u57fa\u65f6\u4ee3<\/div>\n
\u901a\u8fc7\u5149\u9057\u4f20\u5b66\u5b9e\u73b0\u5355\u4e2a\u795e\u7ecf\u5143\u7684\u5149\u654f\u64cd\u4f5c<\/div>\n
\u5b9e\u9a8c\u5ba4\u521b\u9020\u5305\u542b6\u79cd\u78b1\u57fa\u7684\u65b0DNA\u5206\u5b50<\/div>\n
\uff08\u6309\u6210\u679c\u53d1\u5e03\u65f6\u95f4\u6392\u5e8f\uff09<\/div>\n
\u00a0<\/div>\n
1.\u00a0\u5728\u5355\u7ec6\u80de\u6c34\u5e73\u8fdb\u884c\u9057\u4f20\u6027\u75be\u75c5\u7b5b\u67e5<\/div>\n\n
\n
\"RmFicvQBAkgCAbF9eGxibicPNgfddTxg7hYJ4p4ptZ5UkfsFuIaNsSz7g1hCBmq82cWBicu1eYibwFFR8Uj8TrwgS4Q\"\/<\/figure><\/div>\n\n
2017\u5e743\u67081\u65e5\u300aNature Method\u300b\u7684\u520a\u6587\u8868\u793a\uff0c\u9057\u4f20\u7b5b\u67e5\u8fdb\u5165\u5355\u7ec6\u80de\u65f6\u4ee3\u3002\u6587\u4e2d\u7684\u56db\u9879\u7814\u7a76\u5229\u7528\u5355\u4e2a\u7ec6\u80de\u4f5c\u4e3a\u5fae\u6270\u5b9e\u9a8c\u5ba4\uff0c\u5f00\u53d1\u51fa\u65b0\u5174\u65b9\u6cd5\uff0c\u5305\u62ec\u4e24\u4e2a\u4e3b\u8981\u7b56\u7565\uff0c\u7528\u4e8e\u5c06\u9057\u4f20\u7269\u8d28\u7684\u53d8\u5316\u4e0e\u7ec6\u80de\u8868\u578b\u76f8\u5173\u8054\u3002\u4e00\u662f\u5728\u5fae\u5b54\u677f\u4e2d\u7684\u7ec6\u80de\u4e0a\u8fdb\u884c\u7684\u82af\u7247\u7b5b\u67e5\uff0c\u4e8c\u662f\u5728\u5355\u4e2a\u7ec6\u80de\u6837\u672c\u4e2d\u5e73\u884c\u3001\u5feb\u901f\u7b5b\u9009\u6570\u5343\u4e2a\u9057\u4f20\u53d8\u5f02\u7684\u6df7\u5408\u7b5b\u67e5(pooled screen) [1]\u3002<\/div>\n
<\/div>\n
\u62d3\u5c55\u9605\u8bfb<\/div>\n
<\/div>\n
1\uff09 \u6587\u732e\u539f\u6587\uff1ahttps:\/\/www.nature.com\/articles\/nmeth.4196<\/div>\n
2\uff09\u6587\u732e\u89e3\u8bfb\uff1a\u9057\u4f20\u7b5b\u67e5\u5f00\u542f\u5355\u7ec6\u80de\u65f6\u4ee3<\/a><\/div>\n
3\uff09\u5355\u7ec6\u80de\u7814\u7a76\u4e13\u5bb6\u4e13\u8bbf\uff1a\u5317\u4eac\u5927\u5b66\u5f20\u6cfd\u6c11\u8bfe\u9898\u7ec4<\/a>\u00a0 \u4e0a\u6d77\u4ea4\u5927\u65bd\u5947\u60e0\u6559\u6388<\/a><\/div>\n
4\uff09\u9057\u4f20\u75c5\u4e13\u5bb6\u4e13\u8bbf\uff1a\u9ec4\u5c1a\u5fd7<\/a>\u00a0\u00a0\u5317\u5927\u4e00\u9662\u4e01\u6d01<\/a>\u00a0 \u00a0\u987e\u5927\u592b<\/a>\u00a0 \u00a0\u590d\u65e6\u513f\u79d1\u9ec4\u56fd\u82f1<\/a>\u00a0\u00a0\u54c8\u4f5b\u533b\u5b66\u9662\u6c88\u4ea6\u5e73<\/a><\/div>\n
<\/div>\n
<\/div>\n
2.\u4eba\u5de5\u5408\u6210\u5b8c\u6574\u6d3b\u6027\u67d3\u8272\u4f53<\/div>\n\n
\n
\"RmFicvQBAkgCAbF9eGxibicPNgfddTxg7hYUcBEMtUDib2bLc18ZpSiadv1Oxb2AFSITkxk6HZZLvnqmINV0PcCoBmg\"\/<\/figure><\/div>\n\n
2017\u5e743\u670810\u65e5\uff0c\u300a\u79d1\u5b66\u300b\u671f\u520a\u6742\u5fd7\u4ee57\u7bc7\u8bba\u6587\u7684\u4e13\u520a\u53ca\u5c01\u9762\u6587\u7ae0\u5f62\u5f0f\u53d1\u8868\u4e86\u4e2d\u5916\u79d1\u5b66\u5bb6\u5229\u7528\u5316\u5b66\u7269\u8d28\u6210\u529f\u5408\u62105\u6761\u4eba\u5de5\u8bbe\u8ba1\u7684\u917f\u9152\u9175\u6bcd\u67d3\u8272\u4f53\uff0c\u51717\u7bc7\u7814\u7a76\u957f\u6587\uff0c\u5176\u4e2d4\u7bc7\u6765\u81ea\u4e2d\u56fd\uff0c\u5305\u62ec\u5929\u6d25\u5927\u5b66\u5143\u82f1\u8fdb\u8bfe\u9898\u7ec4\uff0c\u6e05\u534e\u5927\u5b66\u751f\u547d\u79d1\u5b66\u9662\u6234\u4fca\u5f6a\u8bfe\u9898\u7ec4\uff0c\u534e\u5927\u57fa\u56e0\u6768\u7115\u660e\u9662\u58eb\u4e0e\u7231\u4e01\u5821\u5927\u5b66Yizhi Cai\u8bfe\u9898\u7ec4\u3002\u6211\u56fd\u79d1\u5b66\u5bb6\u5408\u6210\u4e86\u5176\u4e2d4\u6761\u4eba\u5de5\u8bbe\u8ba1\u7684\u917f\u9152\u9175\u6bcd\u67d3\u8272\u4f53\uff0c\u4e5f\u6210\u4e3a\u7ee7\u7f8e\u56fd\u4e4b\u540e\u7b2c\u4e8c\u4e2a\u5177\u5907\u771f\u6838\u57fa\u56e0\u7ec4\u8bbe\u8ba1\u4e0e\u6784\u5efa\u80fd\u529b\u7684\u56fd\u5bb6\u3002\u6807\u5fd7\u7740\u4eba\u7c7b\u5411\u201c\u518d\u9020\u751f\u547d\u201d\u53c8\u8fc8\u8fdb\u4e00\u5927\u6b65[2]\u3002<\/div>\n
<\/div>\n
\u62d3\u5c55\u9605\u8bfb<\/div>\n
<\/div>\n
1\uff09 \u6587\u732e\u539f\u6587\uff1ahttp:\/\/science.sciencemag.org\/content\/355\/6329<\/div>\n
2\uff09\u6587\u732e\u7b2c\u4e00\u4f5c\u8005\u4e13\u8bbf\uff1a\u539f\u6e05\u534e\u5927\u5b66\u6234\u4fca\u5f6a<\/a>\u3001\u56fd\u5bb6\u57fa\u56e0\u5e93\u6c88\u73a5<\/a>\u00a0<\/div>\n
<\/div>\n
<\/div>\n
3.\u00a0\u9996\u4e2a\u57fa\u4e8e\u80bf\u7624\u751f\u7269\u6807\u5fd7\u7269\uff0c\u800c\u4e0d\u8003\u8651\u80bf\u7624\u6765\u6e90\u7684\u836f\u7269<\/div>\n\n
\n
\"RmFicvQBAkgCAbF9eGxibicPNgfddTxg7hYEMTwjz6VUn0cZiazQX99myoqeHMKGzJ8JjNYnr21IeQPnqAicjIAuWhw\"\/<\/figure><\/div>\n\n
2017\u5e745\u670824\u65e5\uff0cFDA\u52a0\u901f\u6279\u51c6\u4e86Merck\u7684PD-1\u6291\u5236\u5242Keytruda(pembrolizumab)\u7528\u4e8e\u6cbb\u7597\u643a\u5e26\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\u9ad8\uff08MSI-H\uff09\u6216\u9519\u914d\u4fee\u590d\u7f3a\u9677\uff08dMMR\uff09\u5206\u5b50\u7279\u5f81\u4e14\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u7684\u6210\u4eba\u548c\u513f\u7ae5\u764c\u75c7\u60a3\u8005\u3002\u8fd9\u662f\u9996\u4e2a\u88ab\u6279\u51c6\u7684\u57fa\u4e8e\u80bf\u7624\u751f\u7269\u6807\u5fd7\u7269\uff0c\u800c\u4e0d\u8003\u8651\u80bf\u7624\u6765\u6e90\u7684\u836f\u7269[3]\u3002<\/div>\n
<\/div>\n
\u62d3\u5c55\u9605\u8bfb<\/div>\n
<\/div>\n
1\uff09 FDA\u539f\u6587\uff1ahttps:\/\/www.fda.gov\/newsevents\/newsroom\/pressannouncements\/ucm560167.htm<\/div>\n
2\uff09\u00a0\u9b4f\u4e8e\u5168\u9662\u58eb\uff1a\u751f\u7269\u6cbb\u7597\u4e3a\u764c\u75c7\u6cbb\u7597\u5e26\u6765\u65b0\u5e0c\u671b<\/a><\/div>\n
3\uff09\u514d\u75ab\u6cbb\u7597\u76f8\u5173\uff1a10\u4f4d\u4e13\u5bb6\u89e3\u8bfbFDA\u6279\u51c6\u9996\u4e2a\u591a\u764c\u79cd\u591a\u57fa\u56e0\u68c0\u6d4b\u5e73\u53f0<\/a>\u00a0 \u00a0\u56fd\u5185\u9996\u6b3e\u8bc4\u4ef7\u514d\u75ab\u836f\u7269\u7597\u6548\u7684 ctDNA panel<\/a>\u00a0\u00a0<\/div>\n
<\/div>\n
<\/div>\n
4.\u00a0\u53d1\u73b0\u6291\u5236\u80a5\u80d6\u7684\u80a0\u9053\u5fae\u751f\u7269<\/div>\n\n
\n
\"RmFicvQBAkgCAbF9eGxibicPNgfddTxg7hYx0K2ZFeSvVgia4IVL1opbD7ScN7BhCCq6NmESDzwoIzM31QYl9Ciaf3A\"\/<\/figure><\/div>\n\n
2017\u5e746\u670820\u65e5\uff0c\u300aNature Medicine\u300b\u520a\u6587\u5173\u4e8e\u53d1\u73b0\u6291\u5236\u80a5\u80d6\u7684\u80a0\u9053\u5fae\u751f\u7269\u2014\u2014\u591a\u5f62\u62df\u6746\u83cc\u3002\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u745e\u91d1\u533b\u9662\u7684\u5b81\u5149\u9662\u58eb\u3001\u738b\u536b\u5e86\u6559\u6388\u56e2\u961f\u548c\u534e\u5927\u57fa\u56e0\u7684Karsten Kristiansen\u6559\u6388\u56e2\u961f\u5171\u540c\u5b8c\u6210\u8fd9\u9879\u7814\u7a76\uff0c\u4ee5\u4e2d\u56fd\u7684\u6c49\u65cf\u5e74\u8f7b\u4eba\u4e3a\u7814\u7a76\u5bf9\u8c61\u3002\u7814\u7a76\u53d1\u73b0\u80a5\u80d6\u4eba\u7fa4\u4e2d\u8c37\u6c28\u9178\u7684\u542b\u91cf\u975e\u5e38\u9ad8\uff0c\u4e0e\u82d7\u6761\u4eba\u7fa4\u5f62\u6210\u663e\u8457\u5dee\u5f02\uff0c\u5e76\u4e14\u5728\u80a5\u80d6\u4eba\u7fa4\u4e2d\u8c37\u6c28\u9178\u7684\u542b\u91cf\u4e0e\u591a\u5f62\u62df\u6746\u83cc\u7684\u6570\u91cf\u5448\u53cd\u6bd4\u3002\u901a\u8fc7\u5bf9\u5c0f\u9f20\u79fb\u690d\u591a\u5f62\u62df\u6746\u83cc\u7684\u52a8\u7269\u5b9e\u9a8c\uff0c\u4ee5\u53ca\u5206\u679023\u540d\u63a5\u53d7\u8fc7\u8896\u72b6\u80c3\u5207\u9664\u672f\u7684\u5fd7\u613f\u8005\u7684\u80a0\u9053\u5fae\u751f\u7269\u5f97\u5230\u8fdb\u4e00\u6b65\u9a8c\u8bc1\uff0c\u4ece\u7814\u7a76\u4e0a\u9884\u793a\u7740\u901a\u8fc7\u80a0\u9053\u5fae\u751f\u7269\u6765\u6cbb\u7597\u80a5\u80d6\u662f\u53ef\u884c\u7684[4]\u3002<\/div>\n
<\/div>\n
\u62d3\u5c55\u9605\u8bfb<\/div>\n
<\/div>\n
1\uff09 \u6587\u732e\u539f\u6587\uff1ahttp:\/\/science.sciencemag.org\/content\/early\/2017\/10\/24\/science.aaq0180\/tab-figures-data<\/div>\n
2\uff09\u5fae\u751f\u7269\u4e13\u5bb6\u4e13\u8bbf\uff1a\u6768\u4e91\u751f<\/a> \u6768\u745e\u99a5<\/a> \u674e\u5b81<\/a> \u79e6\u6960<\/a>\u00a0 \u9646\u7956\u5b8f\/\u70ed\u5fc3\u80a0\u5148\u751f\/\u8d75\u67cf\u95fb<\/a><\/div>\n
<\/div>\n
<\/div>\n
5.\u00a0\u901a\u8fc7\u6db2\u4f53\u6d3b\u68c0\u7b5b\u67e5\u6ca1\u6709\u75c7\u72b6\u7684\u65e9\u671f\u9f3b\u54bd\u764c<\/div>\n\n
\n
\"RmFicvQBAkgCAbF9eGxibicPNgfddTxg7hYEqkvDl7VqgONjbqNGdQSNDKqp501iaKYBdvnDIRSfpW94OnEibdGAlgw\"\/<\/figure><\/div>\n\n
2017\u5e748\u670810\u65e5\uff0c\u300aThe New EnglandJournal of Medicine\u300b\u520a\u6587\u5173\u4e8e\u5362\u715c\u660e\u56e2\u961f\u901a\u8fc7\u6db2\u4f53\u6d3b\u68c0\u7b5b\u67e5\u65e9\u671f\u9f3b\u54bd\u764c\u7684\u6210\u679c\u3002\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\u7684\u5362\u715c\u660e\u56e2\u961f\u68c0\u6d4b\u8840\u6d46\u4e2d\u6e38\u79bbEB\u75c5\u6bd2DNA\uff0c\u5bf920174\u540d40-62\u5c81\u7684\u4e2d\u56fd\u7537\u6027\u5fd7\u613f\u8005\u8fdb\u884c\u4e86\u7b5b\u67e5\uff0c\u7279\u5f02\u6027\u548c\u654f\u611f\u6027\u5206\u522b\u4e3a97.1%\u548c98.6%\u3002\u68c0\u6d4b\u6e38\u79bbEB\u75c5\u6bd2DNA\u5bf9\u9f3b\u54bd\u764c\u7684\u9633\u6027\u9884\u6d4b\u7387\u4e3a11%\uff0c\u7b5b\u67e5\u51fa\u7684\u60a3\u8005\u4e2dI\u671f\u60a3\u8005\u6bd4\u4f8b\u4e3a47%[5]\u3002<\/div>\n
<\/div>\n
\u62d3\u5c55\u9605\u8bfb<\/div>\n
<\/div>\n
1\uff09 \u6587\u732e\u539f\u6587\uff1ahttp:\/\/www.nature.com\/nature\/journal\/vaap\/ncurrent\/full\/nature24644.html<\/div>\n
2\uff09\u80bf\u7624\u4e13\u5bb6\u4e13\u8bbf\uff1a\u00a0\u675c\u514b\u5927\u5b66\u960e\u6d77<\/a>\u00a0 \u718a\u78ca<\/a>\u00a0\u00a0\u8bb8\u660e\u708e<\/a>\u00a0\u00a0\u00a0<\/div>\n
<\/div>\n
<\/div>\n
<\/div>\n
6.\u00a0\u5168\u7403\u9996\u4e2a\u80bf\u7624\u514d\u75ab\u6cbb\u7597CRA-T\u7597\u6cd5\u83b7\u6279\u4e0a\u5e02<\/div>\n\n
\n
\"RmFicvQBAkgCAbF9eGxibicPNgfddTxg7hYGjUZDyeOpiaun04sZiaGGFAhgACsDN5KfnlicGYME05QOGT5pgO1kmVFA\"\/<\/figure><\/div>\n\n
2017\u5e748\u670830\u65e5\uff0cFDA\u5ba3\u5e03\u6279\u51c6\u8bfa\u534eCAR-T\u7ec6\u80de\u7597\u6cd5\u6b63\u5f0f\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027\u513f\u7ae5\u3001\u9752\u5c11\u5e74B-\u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff0c\u5176\u5546\u54c1\u540d\u4e3aKymriah(tisagenlecleucel)\u3002FDA\u79f0\u5176\u4e3a\u201c\u8fd9\u662f\u4e00\u9879\u5386\u53f2\u6027\u7684\u51b3\u8bae\uff0c\u4f7f\u5f97\u7f8e\u56fd\u7684\u7b2c\u4e00\u79cd\u57fa\u56e0\u6cbb\u7597\u65b9\u6cd5\u5e94\u7528\u5728\u6cbb\u7597\u764c\u75c7\u4ee5\u53ca\u5176\u4ed6\u4e25\u91cd\u548c\u5371\u53ca\u751f\u547d\u7684\u75be\u75c5\u4e0a\u201d[6] \u3002<\/div>\n
<\/div>\n
\u62d3\u5c55\u9605\u8bfb<\/div>\n
<\/div>\n
1\uff09 FDA\u539f\u6587\uff1ahttps:\/\/www.fda.gov\/newsevents\/newsroom\/pressannouncements\/ucm574058.htm<\/div>\n
2\uff09\u4e13\u8bbf\u5317\u5927\u56fd\u9645\u533b\u9662\u526f\u9662\u957f\u6881\u519b<\/a>\u00a0\u00a0\u00a0\u4e13\u8bbf\u764c\u75c7\u79d1\u666e\u4f5c\u5bb6\u83e0\u841d<\/a>\u00a0\u00a0<\/div>\n
<\/div>\n
<\/div>\n
<\/div>\n
7.\u00a0\u5408\u6210\u201c\u57fa\u56e0\u7535\u8def\u201d\u7cbe\u51c6\u6fc0\u6d3b\u62b5\u6297\u764c\u7ec6\u80de\u7684\u514d\u75ab\u7cfb\u7edf<\/div>\n\n
\n
\"RmFicvQBAkgCAbF9eGxibicPNgfddTxg7hYY2W7WHSVlICGgy2giciavIC1MV7lfJtVFsiblpBMZjEq09dECiaJpWQ7gQ\"\/<\/figure><\/div>\n\n
2017\u5e7410\u670820\u65e5\uff0c\u300aCell\u300b\u520a\u6587\u5173\u4e8eMIT\u7684\u5408\u6210\u751f\u7269\u5b66\u4e13\u5bb6\u7684Timothy K. Lu\u56e2\u961f\u5408\u6210\u201c\u57fa\u56e0\u7535\u8def\u201d\u7cbe\u51c6\u6fc0\u6d3b\u5bf9\u6297\u764c\u7ec6\u80de\u7684\u514d\u75ab\u7cfb\u7edf\u7684\u7814\u7a76\u6210\u679c\u3002Timothy K. Lu\uff08\u5362\u51a0\u8fbe\uff09\u8bbe\u8ba1\u4e86\u4e00\u4e2a\u6a21\u5757\u5316\u7684\u201c\u57fa\u56e0\u7535\u8def\u201d\uff0c\u901a\u8fc7\u75c5\u6bd2\u8fdb\u5165\u5e76\u7cbe\u51c6\u8bc6\u522b\u764c\u7ec6\u80de\u5185\uff0c\u5229\u7528\u8f6c\u5f55\u56e0\u5b50\u5bf9\u764c\u7ec6\u80de\u8fdb\u884c\u7cbe\u51c6\u8bc6\u522b\uff0c\u589e\u5f3a\u514d\u75ab\u53cd\u5e94\u62b5\u6297\u764c\u75c7[7]\u3002<\/div>\n
<\/div>\n
\u62d3\u5c55\u9605\u8bfb<\/div>\n
<\/div>\n
1\uff09 \u6587\u732e\u539f\u6587\uff1ahttp:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(17)31143-1<\/div>\n
2\uff09\u9996\u4e2a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u526f\u4f5c\u7528\u5171\u8bc6\u53d1\u5e03<\/a><\/div>\n
<\/div>\n
<\/div>\n
<\/div>\n
8.\u00a0\u57fa\u56e0\u7f16\u8f91\u8fdb\u5165\u5355\u78b1\u57fa\u65f6\u4ee3<\/div>\n\n
\n
\"RmFicvQBAkgCAbF9eGxibicPNgfddTxg7hYVAmXzF9dsojQoQOiaGqRGVdwia9pasLVz6uRK2CibKMBEdRb0tgac1FTQ\"\/<\/figure><\/div>\n\n
2017\u5e7410\u670826\u65e5\uff0c\u300aScience\u300b\u548c\u300aNature\u300b\u53d1\u8868\u4e24\u9879\u7814\u7a76\u6210\u679c\uff0c\u8868\u660e\u53ef\u4ee5\u4e0d\u5207\u65adDNA\u548cRNA\u5e8f\u5217\u60c5\u51b5\u4e0b\uff0c\u76f4\u63a5\u5bf9\u78b1\u57fa\u8fdb\u884c\u7f16\u8f91\uff0c\u5b9e\u73b0\u5c06\u817a\u560c\u5464\uff08A\uff09\u4fee\u6539\u4e3a\u9e1f\u560c\u5464\uff08G\uff09\u3002\u4e24\u9879\u6280\u672f\u7684\u7f16\u8f91\u6548\u7387\u5747\u8fbe\u523050%\u4ee5\u4e0a\uff0c\u9ad8\u4e8eCRISPR\u3002\u8fd9\u4e24\u9879\u7814\u7a76\u5206\u522b\u662f\u5f20\u950b\u535a\u58eb\u56e2\u961f\u901a\u8fc7\u7ed3\u5408CRISPR-Cas13\u4e0eRNA\u817a\u82f7\u8131\u6c28\u9176\uff08ADAR2\uff09\uff0c\u6784\u5efa\u4e86REPAIR\u7f16\u8f91\u4f53\u7cfb[8]\uff1bBroad Institude\u7684David R.Liu\u535a\u58eb\u56e2\u961f\u901a\u8fc7CRISPR-Cas9\u548cDNA\u817a\u82f7\u8131\u6c28\u9176ecTadA\u4e3a\u57fa\u7840\u7684\u57fa\u56e0\u7f16\u8f91\u5668ABEs[9]\u3002<\/div>\n
<\/div>\n
\u62d3\u5c55\u9605\u8bfb<\/div>\n
<\/div>\n
1\uff09 \u6587\u732e\u539f\u6587\uff1ahttp:\/\/science.sciencemag.org\/content\/early\/2017\/10\/24\/science.aaq0180\/tab-figures-data\u00a0<\/div>\n
http:\/\/www.nature.com\/nature\/journal\/vaap\/ncurrent\/full\/nature24644.html<\/div>\n
2\uff09FDA\u8349\u62df\u57fa\u56e0\u7ec4\u7f16\u8f91\u533b\u7597\u7528\u54c1\u3001\u98df\u7269\u548c\u57fa\u56e0\u5de5\u7a0b\u52a8\u7269\u76d1\u7ba1\u529e\u6cd5<\/a><\/div>\n
<\/div>\n
<\/div>\n
9.\u00a0\u901a\u8fc7\u5149\u9057\u4f20\u5b66\u5b9e\u73b0\u5355\u4e2a\u795e\u7ecf\u5143\u7684\u5149\u654f\u64cd\u4f5c<\/div>\n\n
\n
\"RmFicvQBAkgCAbF9eGxibicPNgfddTxg7hYNUn6YWCyymYic8hAX5ibEwj9WwjAPDQCgBAj8X6SYjtWdfBJIQ77wYPQ\"\/<\/figure><\/div>\n\n
2017\u5e7411\u670813\u65e5\uff0c\u300aNature Neuroscience\u300b\u520a\u6587\u5173\u4e8e\u9ebb\u7701\u7406\u5de5\u5b66\u9662\u548c\u5df4\u9ece\u7b1b\u5361\u5c14\u5927\u5b66\u7814\u7a76\u8005\u901a\u8fc7\u5149\u9057\u4f20\u5b66\u5b9e\u73b0\u5355\u4e2a\u795e\u7ecf\u5143\u7684\u5149\u654f\u64cd\u4f5c\u7684\u7814\u7a76\u6210\u679c\u3002\u7814\u7a76\u8005\u901a\u8fc7\u7ed3\u5408\u65b0\u578b\u5149\u654f\u86cb\u767dsoCoChR\u4e0e\u53cc\u5149\u5b50\u8ba1\u7b97\u673a\u751f\u6210\u5168\u606f\u6280\u672f\uff08CGH\uff09\uff0c\u5b9e\u73b0\u5bf9\u5355\u4e2a\u795e\u7ecf\u5143\u7684\u5149\u654f\u64cd\u4f5c\uff0c\u5c06\u54cd\u5e94\u65f6\u95f4\u538b\u7f29\u81f31\u6beb\u79d2\u5185\uff0c\u4e0e\u771f\u6b63\u7684\u795e\u7ecf\u5143\u6d3b\u52a8\u76f8\u5dee\u65e0\u51e0[10]\u3002<\/div>\n
<\/div>\n
\u62d3\u5c55\u9605\u8bfb<\/div>\n
<\/div>\n
1\uff09 \u6587\u732e\u539f\u6587\uff1ahttps:\/\/www.nature.com\/articles\/s41593-017-0018-8<\/div>\n
2\uff09Nature\uff1aDNA\u6d4b\u5e8f40\u5e74\uff0c\u4ece\u6280\u672f\u9a71\u52a8\u5230\u5e94\u7528\u9a71\u52a8<\/a><\/div>\n
<\/div>\n
<\/div>\n
<\/div>\n
10.\u00a0\u5b9e\u9a8c\u5ba4\u521b\u9020\u5305\u542b6\u79cd\u78b1\u57fa\u7684\u65b0DNA\u5206\u5b50<\/div>\n\n
\n
\"RmFicvQBAkgCAbF9eGxibicPNgfddTxg7hYVuHkGibE5WPKcpXmaM25EFLd89HzbSQjS7d7Ko8xHW0onYYKQXjNeCA\"\/<\/figure><\/div>\n\n
2017\u5e7411\u670830\u65e5\uff0c\u300aNature\u300b\u520a\u6587\u5173\u4e8e\u52a0\u5ddeScripps\u7814\u7a76\u6240\u7684Floyd Romesberg\u6559\u6388\u6210\u529f\u5728\u5b9e\u9a8c\u5ba4\u521b\u9020\u4e86\u81ea\u7136\u754c\u4e2d\u4e0d\u5b58\u5728\u7684X-Y\u78b1\u57fa\u5bf9\u548c\u76f8\u5e94\u7684\u6c28\u57fa\u9178\u3002Romesberg\u6559\u6388\u56e2\u961f\u521b\u9020\u4e86\u4e00\u79cd\u6539\u826f\u8fc7\u7684tRNA\u4ee5\u53ca\u76f8\u5e94\u7684\u6c28\u57fa\u9178\uff0c\u80fd\u8bc6\u522b\u4eba\u9020\u78b1\u57fa\uff0c\u5e76\u5c06\u4eba\u5de5\u5408\u6210\u7684\u6c28\u57fa\u9178\u8fd0\u8f93\u5230\u6838\u7cd6\u4f53\u4e2d\uff0c\u540c\u65f6\u6574\u5408\u8fdb\u4e86\u5927\u80a0\u6746\u83cc\u6240\u8868\u8fbe\u7684\u86cb\u767d\u4e2d\u3002\u8fd9\u9884\u793a\u7740\u4e5f\u5c31\u662f\u8bf4\u672a\u6765\u4eba\u4eec\u5c06\u53ef\u4ee5\u6309\u7167\u81ea\u5df1\u7684\u8981\u6c42\u64cd\u7eb5\u548c\u6539\u9020\u9057\u4f20\u4fe1\u606f\uff0c\u800c\u4e0d\u518d\u4ec5\u4ec5\u81ea\u7136\u754c\u7684ATCG\u56db\u79cd\u78b1\u57fa\u3002\u4f8b\u5982Romesberg\u6559\u6388\u8868\u793a\u5df2\u6210\u529f\u5730\u5c06\u4eba\u5de5\u5408\u6210\u7684\u78b1\u57fa\u5bf9\u63d2\u5165\u5230\u5bf9\u6297\u751f\u7d20\u8010\u836f\u7ec6\u83cc\u57fa\u56e0\u7684\u5173\u952e\u4f4d\u70b9\u4e0a\uff0c\u4ece\u800c\u4f7f\u5f97\u8868\u8fbe\u8fd9\u79cd\u78b1\u57fa\u7684\u7ec6\u83cc\u5bf9\u4e8e\u9752\u9709\u7d20\u7c7b\u6297\u751f\u7d20\u5f02\u5e38\u654f\u611f[11]\u3002<\/div>\n
\u00a0<\/div>\n
\u62d3\u5c55\u9605\u8bfb<\/div>\n
1\uff09 \u6587\u732e\u539f\u6587\uff1ahttps:\/\/www.nature.com\/articles\/nature24659<\/div>\n
2\uff09\u4e00\u5957PPT\u6d45\u8c08\u5408\u6210\u57fa\u56e0\u7ec4\u6280\u672f\u548c\u4ea7\u4e1a<\/a><\/div>\n
\u00a0<\/div>\n
\u7f16\u540e\u8bb0<\/div>\n
\u4ece\u5341\u5927\u6280\u672f\u7684\u9886\u57df\u770b\uff0c\u8fd9\u91cc\u5984\u52a0\u603b\u7ed3\u4e0b\uff0c\u57fa\u56e0\u79d1\u6280\u7684\u6280\u672f\u53d1\u5c55\u53ef\u80fd\u5f80\u4ee5\u4e0b\u51e0\u4e2a\u89d2\u5ea6\u53d1\u5c55\uff1a\u5176\u4e00\u662f\u66f4\u7cbe\u7ec6\uff0c\u4ece\u57fa\u56e0\u7ec4\u5230\u5355\u7ec6\u80de\u5230\u5355\u78b1\u57fa\u6c34\u5e73\u7684\u5206\u5b50\u6807\u8bb0\u9274\u5b9a\u3001\u64cd\u4f5c\u548c\u5408\u6210\uff1b\u5176\u4e8c\u662f\u66f4\u8de8\u754c\uff0c\u57fa\u56e0\u79d1\u6280\u8fd9\u4e2a\u65b0\u5174\u9886\u57df\u4ece2000\u5e74\u521d\u4ea7\u4e1a\u5316\u63a8\u52a8\u6280\u672f\u8f6c\u5316\u5f00\u59cb\u5c31\u9884\u793a\u7740\u662f\u534f\u540c\u521b\u65b0\uff0c\u9664\u4e86\u5e38\u89c1\u7684\u9057\u4f20\u5b66\u7ed3\u5408\u751f\u7269\u4fe1\u606f\u3001\u8ba1\u7b97\u673a\u6280\u672f\u4e4b\u5916\uff0c\u7535\u5b50\u5de5\u7a0b\u5b66\uff08\u57fa\u56e0\u5408\u6210\uff0cDNA\u8ba1\u7b97\u673a\uff09\uff0c\u7269\u7406\u5b66\uff08\u5149\u9057\u4f20\u5b66\uff09\u4ee5\u53ca\u66f4\u591a\u5b66\u79d1\u6280\u672f\u5c06\u548c\u57fa\u56e0\u79d1\u6280\u878d\u5408\uff0c\u4ea7\u751f\u805a\u53d8\u6548\u5e94\uff1b\u5176\u4e09\u66f4\u843d\u5730\uff0c\u5f53\u8bc4\u8bba\u5bb6\u5984\u52a0\u8bc4\u8bba\uff08\u53ef\u80fd\u5305\u62ec\u7b14\u8005\u672c\u4eba\u5728\u5185\uff09\u6807\u51c6\u3001\u8fb9\u754c\u53ca\u98ce\u9669\u65f6\uff0c\u53ef\u4ee5\u6f5c\u5fc3\u94bb\u7814\u8fd9\u4e2a\u9886\u57df\u7684\u65b0\u5174\u6280\u672f\u5728\u751f\u80b2\u3001\u80bf\u7624\u3001\u80a0\u9053\u75be\u75c5\u3001\u519c\u4e1a\u548c\u6d77\u6d0b\u80b2\u79cd\u3001\u5de5\u4e1a\u5fae\u751f\u7269\u7b49\u65b9\u5411\u7684\u5e94\u7528\u6b63\u5728\u4eceBroad\u3001MIT\u3001BGI\u3001Cold Spring\u3001Wyss\u3001\u5357\u79d1\u5927\u7b49\u7814\u7a76\u9662\u8d70\u5411\u4e34\u5e8a\u3001\u836f\u5382\u3001\u8bd5\u9a8c\u7530\u548c\u5e7f\u88a4\u7684\u592a\u5e73\u6d0b\u3002\u4e34\u6e0a\u7fa1\u9c7c\uff0c\u4e0d\u5982\u9000\u800c\u7ed3\u7f51\uff08\u5e03\u4e09\u5c11\uff09\u3002<\/div>\n
\u00a0<\/div>\n
\u53c2\u8003\u6587\u732e<\/div>\n
1.https:\/\/www.nature.com\/articles\/nmeth.4196<\/div>\n
2.http:\/\/science.sciencemag.org\/content\/355\/6329<\/div>\n
3.https:\/\/www.fda.gov\/newsevents\/newsroom\/pressannouncements\/ucm560167.htm<\/div>\n
4.http:\/\/science.sciencemag.org\/content\/early\/2017\/10\/24\/science.aaq0180\/tab-figures-data<\/div>\n
5.http:\/\/www.nature.com\/nature\/journal\/vaap\/ncurrent\/full\/nature24644.html<\/div>\n
6.\u00a0https:\/\/www.fda.gov\/newsevents\/newsroom\/pressannouncements\/ucm574058.htm<\/div>\n
7.http:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(17)31143-1<\/div>\n
8.http:\/\/science.sciencemag.org\/content\/early\/2017\/10\/24\/science.aaq0180\/tab-figures-data<\/div>\n
9.\u00a0http:\/\/www.nature.com\/nature\/journal\/vaap\/ncurrent\/full\/nature24644.html<\/div>\n
10.https:\/\/www.nature.com\/articles\/s41593-017-0018-8<\/div>\n
11.https:\/\/www.nature.com\/articles\/nature24659<\/div>\n
\u00a0<\/div>\n
\u9884\u544a<\/div>\n
\u57fa\u56e0\u884c\u4e1a2017\u5e74\u5ea6\u76d8\u70b9\u3010\u653f\u7b56\u7bc7\u3011<\/div>\n
\u57fa\u56e0\u884c\u4e1a2017\u5e74\u5ea6\u76d8\u70b9\u3010\u4ea7\u4e1a\u7bc7\u3011<\/div>\n
\u7f16\u8005\uff1a\u5e03\u4e09\u5c11\u00a0 \u00a0|\u00a0 \u6821\u5bf9\uff1aCandice\u00a0 \u00a0|\u00a0 \u5ba1\u6838\uff1a\u5341\u4e00\u90ce<\/div>\n
\u00a0<\/div>\n
2017\u5e74\u57fa\u56e0\u884c\u4e1a\u62a5\u544a\u5c06\u53d1\u9001\u81f3\u201c\u57fa\u56e0\u6167\u8bfb\u8005\u7fa4\u201d\uff0c<\/div>\n
\u6b32\u52a0\u5165\u8bfb\u8005\u7fa4\u8bf7\u5148\u6dfb\u52a0\u7ba1\u7406\u5458\u5fae\u4fe1\u9a8c\u8bc1\uff1aDaisy-wdd<\/div>\n
\u6dfb\u52a0\u65f6\u52a1\u5fc5\u6ce8\u660e\u201c\u59d3\u540d-\u5355\u4f4d-\u804c\u4f4d\u201d\uff0c\u6570\u5b57\u5065\u5eb7\u9886\u57df\u76f8\u5173\u4f18\u5148<\/div>\n\n
\n
\"RmFicvQBAkgDnic1wvB8FoQwHpw7g70E2SVjbsDzSfht7UDRia5Q6iciax9PofkezPCxialjm24IwepFC8atiaDuwu75A\"\/<\/figure><\/div>\n\n<\/div>\n
<\/div>\n
<\/div>\n
<\/div>\n
\u76f8\u5173\u9605\u8bfb<\/div>\n
<\/div>\n

\u57fa\u56e0\u884c\u4e1a2017\u5e74\u5ea6\u76d8\u70b9\u3010\u6295\u878d\u8d44\u7bc7\u3011\uff1a55\u5bb6\u4f01\u4e1a\u878d\u8d4490\u4ebf\u5143<\/a>5\u5206\u949f\u8bfb\u5b8c13\u5bb6\u4e0a\u5e02\u57fa\u56e0\u4f01\u4e1aQ3\u8d22\u62a5\uff08\u4e0b\uff09 | \u6295\u521b\u672a\u6765<\/a><\/a>\u201c\u716e\u9152\u8bba\u82f1\u96c4\u201d: \u201d\u57fa\u56e0+\u201d2017\u5e74\u5ea6\u884c\u4e1a\u5927\u4e8b\u4ef6\u96c6\u7ed3\u53f7<\/a>10\u4f4d\u77e5\u540d\u4e13\u5bb6\u89e3\u8bfb | FDA\u6279\u51c6\u9996\u4e2a\u591a\u764c\u79cd\u591a\u57fa\u56e0\u68c0\u6d4b\u5e73\u53f0<\/a><\/a>\u4f1a\u8bae\u7b14\u8bb0 | \u57fa\u56e0\u6167\u534f\u529e\u9996\u5c4a\u4e34\u5e8a\u57fa\u56e0\u68c0\u6d4b\u6807\u51c6\u548c\u89c4\u8303\u4e13\u9898\u7814\u8ba8\u4f1a<\/a><\/div>\n

<\/div>\n
<\/div>\n
<\/div>\n
\n\n
\n
\"RmFicvQBAkgB2Wkia2jicswicwcVoFyjgcfggACN9HiaErH4gXdhT1rGjXrGOpcGb2yWwKlF3VO9l7Dz9E2OP70O2iag\"\/<\/figure><\/div>","protected":false},"excerpt":{"rendered":"

\u5355\u7ec6\u80de\u7b5b\u67e5 \u67d3\u8272\u4f53\u5408\u6210 \u836f\u7269\u57fa\u56e0\u7ec4 \u5fae\u751f\u7269\u7ec4 \u6db2\u4f53\u6d3b\u68c0 \u514d\u75ab\u6cbb\u7597 \u57fa\u56e0\u7f16\u8f91
\n\u5149\u9057\u4f20\u5b66 \u5408\u6210\u78b1\u57fa<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[2000,2001],"class_list":["post-9778","post","type-post","status-publish","format-standard","hentry","category-industryresearch","tag-2000","tag-2001"],"_links":{"self":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/9778","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/comments?post=9778"}],"version-history":[{"count":3,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/9778\/revisions"}],"predecessor-version":[{"id":14350,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/9778\/revisions\/14350"}],"wp:attachment":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/media?parent=9778"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/categories?post=9778"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/tags?post=9778"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}