{"id":9742,"date":"2018-03-04T19:51:38","date_gmt":"2018-03-04T11:51:38","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&mid=100003742&idx=1&sn=0c80b0f09b1d11c3f7dda09c83521629&chksm=6b72bd295c05343f87ada8903c074c3611e84e57bac98be8d6001f71da5d325f0fbca70841a1#rd"},"modified":"2026-04-02T19:26:13","modified_gmt":"2026-04-02T11:26:13","slug":"1025153","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2018\/03\/04\/1025153\/","title":{"rendered":"Grail\u6b32\u8d74\u6e2f\u4e0a\u5e02\uff1b\u8bc1\u76d1\u4f1a\u53ca\u4e0a\u4ea4\u6240\u65b0\u653f\uff1b8\u5bb6\u4f01\u4e1a\u63fd$6\u4ebf\u4f59\u878d\u8d44 | GeneMail\u5468\u62a5"},"content":{"rendered":"

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2.\u300aNature\u300b\uff1a\u513f\u7ae5\u80bf\u7624\u53ea\u670945%\u4e0e\u6210\u4eba\u80bf\u7624\u4e00\u81f4<\/div>\n
\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u5206\u67901699\u4f8b\u513f\u7ae5\u767d\u8840\u75c5\u548c6\u79cd\u5b9e\u4f53\u7624\u7684\u5168\u57fa\u56e0\u7ec4\uff0c\u9274\u5b9a\u51fa142\u4e2a\u80bf\u7624\u9a71\u52a8\u57fa\u56e0\uff0c\u53ea\u670945%\u4e0e\u7c7b\u4f3c\u7684\u6210\u4eba\u764c\u75c7\u4e00\u81f4\u3002\u7814\u7a76\u4e8e3\u67081\u65e5\u53d1\u8868\u3002<\/div>\n
3.\u300aNature\u300b\uff1a\u513f\u7ae5\u80bf\u7624\u6cdb\u57fa\u56e0\u7ec4\u5b66\u7814\u7a76<\/div>\n
\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u9009\u53d6961\u540d\u60a3\u670924\u79cd\u4e0d\u540c\u5206\u5b50\u7c7b\u578b\u764c\u75c7\u7684\u513f\u7ae5\u3001\u9752\u5c11\u5e74\u53ca\u6210\u5e74\u4eba\uff0c\u901a\u8fc7\u5168\u57fa\u56e0\u7ec4\u5e8f\u5217\u53d1\u73b0\u513f\u7ae5\u80bf\u7624\u4e0e\u6210\u4eba\u5b58\u5728\u5dee\u5f02\uff0c\u513f\u7ae5\u80bf\u7624\u5e38\u7531\u5355\u57fa\u56e0\u9a71\u52a8\u3001\u513f\u7ae5\u80bf\u7624\u57fa\u56e0\u7a81\u53d8\u5dee\u5f02\u8f83\u5927\u7b49\u3002\u7814\u7a76\u4e8e3\u67081\u65e5\u53d1\u8868\u3002<\/div>\n
4. \u725b\u7624\u80c3\u5b8f\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u5f97\u5230913\u4e2a\u5fae\u751f\u7269\u57fa\u56e0\u7ec4\u8349\u56fe<\/div>\n
2\u670828\u65e5\uff0c\u300aNature Communications\u300b\u520a\u6587\uff0c\u7814\u7a76\u4eba\u5458\u4ece43\u53ea\u82cf\u683c\u5170\u725b\u8d85\u8fc7800Gb\u7684\u725b\u7624\u80c3\u7684\u5b8f\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6570\u636e\u5f97\u5230913\u4e2a\u7ec6\u83cc\u548c\u53e4\u7ec6\u83cc\u57fa\u56e0\u7ec4\u8349\u56fe\uff0c\u6781\u5927\u63d0\u9ad8\u7624\u80c3\u5fae\u751f\u7269\u57fa\u56e0\u7ec4\u7684\u8986\u76d6\u8303\u56f4\u3002<\/div>\n
5. \u79d1\u6280\u90e8\uff1a2017\u5e74\u5ea6\u4e2d\u56fd\u79d1\u5b66\u5341\u5927\u8fdb\u5c55<\/div>\n
2\u670827\u65e5\uff0c\u7531\u79d1\u6280\u90e8\u7275\u5934\u7684\u201c2017\u5e74\u5ea6\u4e2d\u56fd\u79d1\u5b66\u5341\u5927\u8fdb\u5c55\u201d\u9074\u9009\u7ed3\u679c\u5728\u4eac\u63ed\u6653\u3002\u751f\u547d\u79d1\u5b66\u9886\u57df\u5165\u90092\u9879\uff0c\u5206\u522b\u4e3a\u201c\u5c06\u75c5\u6bd2\u76f4\u63a5\u8f6c\u5316\u4e3a\u6d3b\u75ab\u82d7\u53ca\u6cbb\u7597\u6027\u836f\u7269\u201d\uff1b\u201c\u9175\u6bcd\u957f\u67d3\u8272\u4f53\u7684\u7cbe\u51c6\u5b9a\u5236\u5408\u6210\u201d\u3002<\/div>\n
6. \u6539\u8fdb\u7684CRISPR\/Cas9\u6280\u672f\u6709\u671b\u6839\u6cbb\u4ea8\u5ef7\u987f\u821e\u8e48\u75c7<\/div>\n
2\u670826\u65e5\uff0c\u300aFrontiersin Neuroscience\u300b\u53d1\u6587\uff0c\u7814\u7a76\u4eba\u5458\u7528\u6539\u8fdb\u7684CRISPR\/Cas9\u6280\u672f\u6709\u6548\u5207\u9664\u91cd\u590d\u7684\u4e00\u6761DNA\u94fe\u800c\u4e0d\u662f\u4e24\u6761\uff0c\u589e\u52a0\u4e86\u7f16\u8f91DNA\u94fe\u7684\u7cbe\u786e\u5ea6\uff0c\u4f7f\u5f15\u8d77\u4ea8\u5ef7\u987f\u821e\u8e48\u75c7\u7684\u57fa\u56e0\u5931\u6d3b\u3002<\/div>\n
7. \u7814\u7a76\u8bc1\u5b9e\u4eba\u7c7b\u57fa\u56e0\u7ec4\u975e\u7f16\u7801\u533a\u57df\u91cd\u8981\u6027<\/div>\n
2\u670826\u65e5\uff0c\u300aNature Genetics\u300b\u53d1\u6587\uff0c\u79d1\u5b66\u5bb6\u5229\u752811,257\u4e2a\u5168\u57fa\u56e0\u7ec4\u5e8f\u5217\u548c16,384\u4e2a\u4e03\u805a\u4f53\u6784\u5efa\u4eba\u7c7b\u7269\u79cd\u7684\u5e8f\u5217\u7ea6\u675f\u56fe\u8c31\uff0c\u901a\u8fc7\u6570\u5b66\u5206\u6790\u53d1\u73b0\u8d85\u8fc716,000\u79cd\u5e38\u89c1\u53d8\u5f02\u4f53\u5927\u591a\u4f4d\u4e8e\u57fa\u56e0\u7ec4\u7684\u975e\u7f16\u7801\u533a\u3002<\/div>\n
8. \u5929\u575b\u533b\u9662\uff1a\u63a8\u8fdb\u5168\u56fd\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u533a\u57df\u7f51\u7edc\u5efa\u8bbe<\/div>\n
\u8fd1\u65e5\uff0c\u4f9d\u6258\u4e8e\u5929\u575b\u533b\u9662\u5efa\u8bbe\u7684\u56fd\u5bb6\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u4e34\u5e8a\u533b\u5b66\u7814\u7a76\u4e2d\u5fc3\uff0c\u7387\u5148\u6574\u4f53\u8fc1\u5165\u4f4d\u4e8e\u5357\u56db\u73af\u82b1\u4e61\u5730\u533a\u7684\u5929\u575b\u533b\u9662\u65b0\u5740\u529e\u516c\u3002\u5929\u575b\u533b\u9662\u5c06\u5728\u5168\u56fd\u63a8\u8fdb\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u533a\u57df\u7f51\u7edc\u5efa\u8bbe\uff0c\u901a\u8fc7\u5efa\u7acb\u8986\u76d6\u5168\u56fd29\u4e2a\u7701\uff08\u5e02\uff09\u7684\u7701\u7ea7\u4e34\u5e8a\u533b\u5b66\u7814\u7a76\u4e2d\u5fc3\uff0c\u5b8c\u5584\u6211\u56fd\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u4e34\u5e8a\u7814\u7a76\u7f51\u7edc\u4f53\u7cfb\u5efa\u8bbe\u3002<\/div>\n
\u00a0<\/div>\n
\u4ea7\u4e1a<\/div>\n
\u6536\u8d2d\u4e8b\u4ef6<\/div>\n\n
\n
\"?wx_fmt=png\"\/<\/figure><\/div>\n\n
\u56fe\uff0c\u6765\u81ea\u7f51\u7edc<\/div>\n
1. Bio-Rad\u53d1\u5e032017\u5e74\u8d22\u62a5<\/div>\n
2\u670827\u65e5\uff0cBio-Rad\u53d1\u5e032017\u5e74\u7b2c\u56db\u5b63\u5ea6\u548c\u5168\u5e74\u8d22\u62a5\u3002\u516c\u53f8\u7b2c\u56db\u5b63\u5ea6\u6536\u5165\u540c\u6bd4\u589e\u957f9%\uff0c2017\u5e74\u5168\u5e74\u6536\u516521.6\u4ebf\u7f8e\u5143\uff0c\u6bd42016\u5e74\u589e\u957f4\uff05\u3002<\/div>\n
2. PerkinElmer\u6536\u8d2d\u5355\u7ec6\u80de\u57fa\u56e0\u7ec4\u516c\u53f8RHS<\/div>\n
\u6fb3\u5927\u5229\u4e9a\u5355\u7ec6\u80de\u57fa\u56e0\u7ec4\u5b66\u6280\u672f\u7814\u53d1\u516c\u53f8RHS 2\u670827\u65e5\u5ba3\u5e03\u88abPerkinElmer\u4ee5\u7ea62520\u4e07\u6fb3\u5143\uff081960\u4e07\u7f8e\u5143\uff09\u6536\u8d2d\u3002RHS\u7684\u4e3b\u8981\u5e73\u53f0DOPlify\u53ef\u5bf9\u5c11\u6570\u6216\u5355\u4e2a\u7ec6\u80de\u8fdb\u884c\u5168\u57fa\u56e0\u7ec4\u6269\u589e\u3002<\/div>\n
\u00a0<\/div>\n
\u8d44\u672c<\/div>\n
8 \u5bb6\u516c\u53f8\u5171\u63fd\u8d85 6 \u4ebf\u7f8e\u5143\u878d\u8d44<\/div>\n\n
\n
\"?wx_fmt=png\"\/<\/figure><\/div>\n\n
\u56fe\uff0c\u6765\u81ea\u7f51\u7edc<\/div>\n
1. Helix\u5b8c\u6210 B \u8f6e 2 \u4ebf\u7f8e\u5143\u878d\u8d44<\/div>\n
3\u67081\u65e5\uff0c\u6d88\u8d39\u7ea7\u57fa\u56e0\u68c0\u6d4b\u516c\u53f8Helix\u5b8c\u6210B\u8f6e2\u4ebf\u7f8e\u5143\u878d\u8d44\uff0c\u672c\u8f6e\u878d\u8d44\u7531DFJ Growth\u9886\u6295\u3002\u8d44\u91d1\u5c06\u7528\u4e8e\u7814\u53d1\u57fa\u4e8e\u4e0b\u4e00\u4ee3\u6d4b\u5e8f\u6280\u672f\u7684\u521b\u65b0\u578b\u5065\u5eb7\u4ea7\u54c1\uff0c\u63a8\u5e7f\u5176\u4e2a\u4eba\u57fa\u56e0\u7ec4\u5b66\u4ea7\u54c1\u3002<\/div>\n
2. \u79d1\u6280\u751f\u7269\u83b76000\u4e07\u7f8e\u5143Pre-C\u8f6e\u878d\u8d44<\/div>\n
3\u67082\u65e5\uff0cCAR-T\u7ec6\u80de\u7597\u6cd5\u7814\u53d1\u4f01\u4e1a\u79d1\u6d4e\u751f\u7269\u5ba3\u5e03\u7b7e\u7f726000\u4e07\u7f8e\u5143\u7684Pre-C\u8f6e\u878d\u8d44\u534f\u8bae\uff0c\u8d44\u91d1\u5c06\u4e3b\u8981\u7528\u4e8e\u652f\u6301\u5176\u591a\u4e2aCAR-T\u4ea7\u54c1\u56fd\u5185\u5916\u65b0\u836f\u7533\u62a5\u53ca\u6ce8\u518c\u4e34\u5e8a\u63a8\u8fdb\u3002<\/div>\n
3. \u7ec6\u80de\u7597\u6cd5\u516c\u53f8Rubius Therapeutics\u83b71\u4ebf\u7f8e\u5143\u878d\u8d44<\/div>\n
\u7ec6\u80de\u7597\u6cd5\u521b\u4e1a\u516c\u53f8Rubius Therapeutics\u7ee7\u53bb\u5e74\u83b7\u5f971.2\u4ebf\u7f8e\u5143\u878d\u8d44\u540e\uff0c\u4e8e3\u67081\u65e5\u53c8\u83b7\u5f971\u4ebf\u7f8e\u5143\u878d\u8d44\u3002\u8be5\u516c\u53f8\u81f4\u529b\u4e8e\u4e3a\u60a3\u8005\u63d0\u4f9b\u6cbb\u7597\u80bf\u7624\u548c\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u7684\u7ec6\u80de\u7597\u6cd5\u3002<\/div>\n
4. \u5fae\u751f\u7269\u516c\u53f8Finch Therapeutics\u83b73600\u4e07\u7f8e\u5143\u878d\u8d44<\/div>\n
\u5fae\u751f\u7269\u6cbb\u7597\u516c\u53f8Finch Therapeutics 3\u67081\u65e5\u5728B\u8f6e\u878d\u8d44\u4e2d\u83b7\u5f973600\u4e07\u7f8e\u5143\u878d\u8d44\u3002\u8d44\u91d1\u5c06\u7528\u4e8e\u7814\u53d1\u65b0\u578b\u5fae\u751f\u7269\u7597\u6cd5\u3002<\/div>\n
5. \u764c\u75c7\u6cbb\u7597\u521d\u521b\u516c\u53f8Senti\u83b75300\u4e07\u7f8e\u5143\u878d\u8d44<\/div>\n
\u81f4\u529b\u4e8e\u7814\u53d1\u764c\u75c7\u57fa\u56e0\u7597\u6cd5\u7684\u521d\u521b\u516c\u53f8Senti Biosciences 2\u670828\u65e5\u5ba3\u5e03\u83b7\u5f97\u7531New Enterprise Associates\uff08NEA\uff09\u9886\u6295\u76845300\u4e07\u7f8e\u5143A\u8f6e\u878d\u8d44\u3002\u8be5\u516c\u53f8\u76ee\u6807\u662f\u8bbe\u8ba1\u4f7f\u7ec6\u80de\u548c\u57fa\u56e0\u7597\u6cd5\u66f4\u52a0\u667a\u80fd\u7684\u9057\u4f20\u7535\u8def\u3002<\/div>\n
6.\u00a0\u57fa\u56e0\u7f16\u8f91\u516c\u53f8Inscripta\u5b8c\u62105550\u4e07\u7f8e\u5143\u878d\u8d44<\/div>\n
\u9886\u5148\u7684\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u516c\u53f8Inscripta 2\u670828\u65e5\u5ba3\u5e03\u5b8c\u62105550\u4e07\u7f8e\u5143C\u8f6e\u878d\u8d44\uff0c\u7531M\u00e9rieux D\u00e9veloppement\u548cPaladin Capital Group\u9886\u6295\u3002\u8d44\u91d1\u5c06\u52a0\u901fInscripta\u7684\u57fa\u56e0\u7f16\u8f91\u5de5\u5177\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\uff0c\u5e76\u589e\u5f3a\u5176\u4e13\u5bb6\u56e2\u961f\u3002<\/div>\n
7.\u00a0\u57fa\u56e0\u7597\u6cd5\u516c\u53f8Generation Bio\u83b71\u4ebf\u7f8e\u5143B\u8f6e\u878d\u8d44<\/div>\n
2\u670827\u65e5\uff0c\u57fa\u56e0\u7597\u6cd5\u7814\u53d1\u7684\u9886\u5148\u516c\u53f8Generation Bio\u5ba3\u5e03\u5b8c\u62101\u4ebf\u7f8e\u5143B\u8f6e\u878d\u8d44\u3002\u8d44\u91d1\u5c06\u7528\u4e8e\u901a\u8fc7FDA\u7684\u7814\u7a76\u6027\u65b0\u836f(IND)\u7533\u8bf7\u7a0b\u5e8f\u6765\u63a8\u52a8\u7814\u7a76\u9488\u5bf9\u89c6\u7f51\u819c\u3001\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u548c\u80ba\u90e8\u9057\u4f20\u75be\u75c5\u7b49\u8ba1\u5212\u3002<\/div>\n
8.\u00a0\u57fa\u56e0\u667a\u80fd\u516c\u53f8\u5b89\u5409\u5eb7\u5c14\u5b8c\u6210Pre-A\u8f6e\u878d\u8d44<\/div>\n
\u4f4d\u4e8e\u4e2d\u56fd\u6df1\u5733\u7684\u57fa\u56e0\u667a\u80fd\u516c\u53f8\u5b89\u5409\u5eb7\u5c14\u8fd1\u65e5\u5b8c\u6210\u6570\u5343\u4e07\u5143\u4eba\u6c11\u5e01Pre-A\u8f6e\u878d\u8d44\uff0c\u672c\u8f6e\u878d\u8d44\u7531\u5229\u7533\u8d44\u672c\u9886\u6295\u3002\u8d44\u91d1\u5c06\u7528\u4e8e\u7ee7\u7eed\u5f00\u53d1\u5347\u7ea7\u57fa\u56e0\u667a\u80fd\u7cbe\u51c6\u533b\u7597\u51b3\u7b56\u8f85\u52a9AEGIS\u2122\u7cfb\u7edf\uff0c\u63a8\u5e7f\u6269\u5927\u4e34\u5e8a\u5c42\u9762\u7684\u5e94\u7528\u3002\u5b89\u5409\u5eb7\u5c14\u662f\u4e00\u5bb6\u81f4\u529b\u4e8e\u5efa\u7acb\u57fa\u4e8e\u57fa\u56e0\u5927\u6570\u636e\u7684\u7cbe\u51c6\u533b\u7597\u667a\u80fd\u5e73\u53f0\uff0c\u63a8\u52a8\u5305\u62ec\u764c\u75c7\u5728\u5185\u7684\u4eba\u7c7b\u57fa\u56e0\u75be\u75c5\u7814\u7a76\u7684\u516c\u53f8\u3002<\/div>\n
\u00a0<\/div>\n
\u4f1a\u8bae<\/div>\n
3\u6708\u56fd\u5185\u5916\u5927\u578b\u4f1a\u8bae\u62a2\u5148\u770b<\/div>\n\n
\n
\"?wx_fmt=png\"\/<\/figure><\/div>\n\n
\u56fe\uff0c\u6765\u81eaHIMSS<\/div>\n
1. HIMSS 2018\u5e74\u4f1a<\/div>\n
\u65f6\u95f4\uff1a2018\u5e743\u67085~9\u65e5<\/div>\n
\u5730\u70b9\uff1a\u7f8e\u56fd\u62c9\u65af\u7ef4\u52a0\u65af<\/div>\n
\u70ed\u95e8\u8bdd\u9898\uff1a\u6570\u636e\u5206\u6790\u4e0e\u4e34\u5e8a\u7ba1\u7406\u667a\u80fd\u5316\u3001\u4e92\u8054\u5065\u5eb7\u4e0e\u8fdc\u7a0b\u533b\u7597\u3001\u7f51\u7edc\u4e0e\u9690\u79c1\u5b89\u5168\u3001\u57fa\u56e0\u7ec4\u5b66\u4e0e\u7cbe\u51c6\u533b\u5b66\u7b49\u3002<\/div>\n
\u00a0<\/div>\n
2. 2018\uff08\u7b2c\u56db\u5c4a\uff09\u6df1\u5733\u56fd\u9645\u7cbe\u51c6\u533b\u7597\u5cf0\u4f1a\u66a8\u201c\u4e50\u571f\u6c83\u68ee\u751f\u547d\u79d1\u6280\u4e2d\u5fc3\u201d\u542f\u52a8\u4eea\u5f0f<\/div>\n
\u65f6\u95f4\uff1a2018\u5e743\u670816\u65e5\uff08\u661f\u671f\u4e94\uff09<\/div>\n
\u5730\u70b9\uff1a\u4e2d\u56fd\u6df1\u5733\u00b7\u5927\u9e4f\u65b0\u533a\u4f73\u5146\u4e1a\u4e07\u8c6a\u9152\u5e97<\/div>\n
\u4e3b\u9898\uff1a\u80bf\u7624\u4ee5\u53ca\u751f\u6b96\u5065\u5eb7\u7684\u7cbe\u51c6\u533b\u5b66<\/div>\n
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3. 2018\u5e74\u4e2d\u56fd\u9057\u4f20\u5b66\u4f1a\u9057\u4f20\u54a8\u8be2\u5206\u4f1a\u5e74\u4f1a<\/div>\n
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4. 2018\u5e74\u7b2c\u4e94\u5c4aNGS\u521b\u65b0\u5f00\u53d1\u8005\u5927\u4f1a<\/div>\n
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