\n![\"RmFicvQBAkgDEsUia5jbfibMgeRrNibH1ns0NaxVdCMqRl9Bcn0geKXKbn4CByInShB9u6lDPnKmK1nhKxqqiaRaUzQ\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDEsUia5jbfibMgeRrNibH1ns0NaxVdCMqRl9Bcn0geKXKbn4CByInShB9u6lDPnKmK1nhKxqqiaRaUzQ.gif\")
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<\/figure><\/div>\n\n<\/div>\n<\/div>\n
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\n\n
\n![\"RmFicvQBAkgAHmicttCsevvfJOF8sZwgt09cSeWiamBaRFaFrJcYb8tQVeBlnPWFhQWEaNsLUD5daJNdsegGVkCSA\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAHmicttCsevvfJOF8sZwgt09cSeWiamBaRFaFrJcYb8tQVeBlnPWFhQWEaNsLUD5daJNdsegGVkCSA.jpeg\")
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\u00a0<\/div>\n
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\u9c81\u6559\u6388\u63d0\u5230\u80bf\u7624\u514d\u75ab\u9003\u9038\u662f\u80bf\u7624\u8010\u836f\u3001\u590d\u53d1\u3001\u8f6c\u79fb\u7684\u91cd\u8981\u539f\u56e0\u3002\u79d1\u5b66\u5bb6\u4eec\u7814\u7a76\u53d1\u73b0\uff0c\u80bf\u7624\u7ec6\u80de\u9003\u907f\u673a\u4f53\u514d\u75ab\u7cfb\u7edf\u76d1\u89c6\u7684\u673a\u5236\u975e\u5e38\u590d\u6742\uff0c\u4f46\u6700\u7ec8\u90fd\u662f\u4e3a\u4e86\u9003\u907f\u514d\u75ab\u7cfb\u7edf\u7684\u8bc6\u522b\u548c\u653b\u51fb\uff0c\u8fdb\u800c\u51fa\u73b0\u5728\u4f53\u5185\u751f\u5b58\u548c\u5feb\u901f\u589e\u6b96\u7684\u73b0\u8c61\u3002<\/div>\n
NGS\u6280\u672f\u7684\u98de\u901f\u53d1\u5c55\uff0c\u4f7f\u5f97\u80bf\u7624\u514d\u75ab\u7814\u7a76\u7a81\u98de\u731b\u8fdb\uff0c\u800c\u514d\u75ab\u57fa\u56e0\u7ec4\u5b66\uff08Immunogenomics\uff09\u662f\u5b9e\u73b0\u7cbe\u51c6\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u91cd\u8981\u5de5\u5177\uff1a\u5b83\u53ef\u4ee5\u5e2e\u52a9\u6211\u4eec\u5bf9\u80bf\u7624\u7279\u5f02\u6027\u65b0\u6297\u539f\u8fdb\u884c\u9884\u6d4b\uff0c\u53ef\u4ee5\u5bf9\u4e2a\u4f53\u7684TCR\u5e93\u8fdb\u884c\u5206\u6790\uff0c\u4e5f\u53ef\u4ee5\u5bf9\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\uff08TIL\uff09\u8c31\u7cfb\u8fdb\u884c\u5206\u6790\uff0c\u5bf9\u6574\u4e2a\u80bf\u7624\u7279\u5f02\u7684\u514d\u75ab\u5fae\u73af\u5883\u8fdb\u884c\u7efc\u5408\u7684\u5206\u6790\uff0c\u5bf9\u4e34\u5e8a\u6cbb\u7597\u51b3\u7b56\u63d0\u4f9b\u6709\u529b\u7684\u652f\u6301\u3002<\/div>\n
\u9c81\u6559\u6388\u56e2\u961f\u901a\u8fc7\u591a\u5e74\u7684\u7814\u7a76\u5f00\u53d1\u51fa\u53ef\u4ee5\u5bf9\u80bf\u7624\u6cbb\u7597\u7597\u6548\u8fdb\u884c\u8bc4\u4ef7\u7684TDI\u5206\u6790\u6a21\u578b\uff08Tumor-specific Driver Identification\uff09\uff0c\u901a\u8fc7\u5bf9\u4e0d\u540c\u80bf\u7624\u7684SGAs\uff08somatic genomic alterations\uff09\u548cDEGs\uff08differentially expressed genes\uff09\uff0c\u4ee5\u53ca\u5176\u4ed6\u514d\u75ab\u76f8\u5173\u751f\u7269\u6807\u5fd7\u7269\u8fdb\u884c\u5206\u6790\uff0c\u5bf9\u514d\u75ab\u76f8\u5173\u57fa\u56e0\u8fdb\u884c\u9884\u6d4b\uff0c\u5206\u6790\u80bf\u7624\u7684\u514d\u75ab\u5fae\u73af\u5883\uff0c\u514d\u75ab\u5fae\u73af\u5883\u8c03\u8282\u901a\u8def\u7b49\u7efc\u5408\u4fe1\u606f\uff0c\u4e3a\u7cbe\u51c6\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u4e34\u5e8a\u51b3\u7b56\u63d0\u4f9b\u66f4\u591a\u7684\u652f\u6301\u6570\u636e\u3002<\/div>\n
\u6700\u540e\uff0c\u9c81\u6559\u6388\u8868\u793a\u4eba\u5de5\u667a\u80fd\uff08AI\uff09\u548c\u591a\u7ec4\u5b66\u7efc\u5408\u5206\u6790\u7684\u8054\u5408\u5e94\u7528\uff0c\u4f1a\u8ba9\u6211\u4eec\u7684\u7cbe\u51c6\u533b\u7597\u65f6\u4ee3\u6765\u7684\u66f4\u5feb\uff01<\/div>\n
\u00a0<\/div>\n
\u5468\u5f69\u5b58\u6559\u6388 \uff1a\u4e0a\u6d77\u5e02\u80ba\u79d1\u533b\u9662\u80bf\u7624\u79d1\u4e3b\u4efb\u3001CSCO\u7406\u4e8b<\/div>\n
\u9898\u76ee\uff1a\u300a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u514d\u75ab\u6cbb\u7597\u300b<\/div>\n
\u5468\u6559\u6388\u4ecb\u7ecd\u4e86NSCLC\u4e2d\u514d\u75ab\u6cbb\u7597\u5728\u4e34\u5e8a\u5b9e\u8df5\u5de5\u4f5c\u4e2d\u7684\u5e94\u7528\u65f6\u673a\u95ee\u9898\u3002\u8ba8\u8bba\u4e86PD-1\/PD-L1\u7528\u836f\uff0c\u65e9\u671f\u4f18\u4e8e\u665a\u671f\uff0c\u76ee\u524d\u5728NSCLC\u4e2d\u4e8c\u7ebf\u6cbb\u7597\u662f\u6807\u51c6\uff0c\u90a3\u5728\u8de8\u7ebf\u6cbb\u7597\u4e0a\uff0c\u5982\u4e00\u7ebfvs\u4e8c\u7ebf\u9009\u62e9\u95ee\u9898\uff0c\u957f\u671f\u751f\u5b58\u671f\u6709\u4f55\u5dee\u5f02\uff0c\u7528\u836f\u591a\u957f\u65f6\u95f4\uff08\u4ec0\u4e48\u65f6\u5019\u505c\u836f\uff09\u7b49\u95ee\u9898\u8fdb\u884c\u4e86\u8ba8\u8bba\u3002\u57fa\u4e8e\u76ee\u524d\u7684\u7814\u7a76\u7ed3\u679c\u6765\u770b\uff0c\u7528\u836f\u65f6\u95f4\u8d8a\u957f\u751f\u5b58\u671f\u4f1a\u8d8a\u957f\uff0c\u505c\u836f\u540e\u5728\u4e00\u5b9a\u65f6\u95f4\u5185\u662f\u53ef\u4ee5\u4fdd\u6301\u75be\u75c5\u7a33\u5b9a\u72b6\u51b5\uff1b<\/div>\n
pembrolizumab\u662fPD-L1 TPS>50%\u7684NSCLC\u4e00\u7ebf\u6cbb\u7597\u65b0\u6807\u51c6\uff0c\u514d\u75ab+\u5316\u7597\/IO\u6b63\u5728\u63a2\u7d22\u4e2d\uff0cdurvalumab\u5de9\u56fa\u6cbb\u7597\u663e\u8457\u6539\u5584\u540c\u6b65\u653e\u5316\u7597\u540e\u5c40\u90e8\u665a\u671fNSCLC\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\uff0c\u800cPD-L1\u88ab\u6279\u51c6\u4e3a\u5206\u5b50\u6807\u5fd7\u7269\uff0c\u76ee\u524d\u6b63\u8feb\u5207\u5bfb\u627e\u53ef\u4ee5\u9884\u6d4b\u514d\u75ab\u6cbb\u7597\u7597\u6548\u66f4\u597d\u7684\u6807\u5fd7\u7269\u3002<\/div>\n
\u00a0<\/div>\n
\u5f20\u529b\u6559\u6388 \uff1a\u4e2d\u5c71\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u5185\u79d1\u4e3b\u4efb\u3001CSCO\u5e38\u52a1\u7406\u4e8b<\/div>\n
\u9898\u76ee\uff1a\u300a\u4e2d\u56fd\u514d\u75ab\u6cbb\u7597\u4e34\u5e8a\u7814\u7a76\u300b<\/div>\n
\u5f20\u6559\u6388\u4ee5\u201c\u5168\u7403\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u4e34\u5e8a\u7814\u7a76\u201d\u3001\u201c\u8fdb\u53e3\u514d\u75ab\u6cbb\u7597\u836f\u7269\u4e2d\u56fd\u7814\u7a76\u73b0\u72b6\u4e0e\u7b56\u7565\u201d\u3001\u201c\u56fd\u4ea7\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u836f\u7269\u4e2d\u56fd\u73b0\u72b6\u4e0e\u7b56\u7565\u201d\u3001\u201c\u4e2d\u56fd\u514d\u75ab\u6cbb\u7597\u4e34\u5e8a\u7814\u7a76\u5b58\u5728\u7684\u95ee\u9898\u4e0e\u673a\u9047\u201d4\u4e2a\u65b9\u9762\u4f5c\u4e3a\u4e3b\u7ebf\u8fdb\u884c\u4ecb\u7ecd\uff1b<\/div>\n
\u540c\u65f6\u8868\u793a\u76ee\u524d\u6211\u56fd\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u4e3b\u8981\u7684\u6311\u6218\u5305\u62ec\uff1a\u56fd\u5185\u5916\u540c\u7c7b\u4ea7\u54c1\u8fc7\u591a\u3001\u76f8\u540c\u9002\u5e94\u8bc1\u7ade\u4e89\u5f02\u5e38\u6fc0\u70c8\u3001\u9ad8\u6c34\u5e73PI\u4e0d\u591f\u7528\u3001\u7814\u7a76\u592a\u591a\u60a3\u8005\u4e0d\u591f\uff1b\u800c\u76f8\u5e94\u7684\u673a\u9047\u5305\u62ec\uff1a\u65b0\u7684\u653f\u7b56\u548c\u6cd5\u89c4\u3001\u706b\u70ed\u7684\u7814\u7a76\u6c1b\u56f4\u4e0e\u610f\u8bc6\u3001\u65b0\u7684\u6280\u672f\u4e0e\u4ea7\u54c1\u3001\u65b0\u7684\u8054\u5408\u7b56\u7565\u4e0e\u65b0\u6807\u5fd7\u7269\u6307\u5bfc\u3002<\/div>\n
\u00a0<\/div>\n
\u53f6\u5b9a\u4f1f\u6559\u6388 \uff1a\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u526f\u9662\u957f\u3001CSCO\u5e38\u52a1\u7406\u4e8b<\/div>\n
\u9898\u76ee\uff1a\u300a\u6ccc\u5c3f\u7cfb\u7edf\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u300b<\/div>\n
\u53f6\u6559\u6388\u5bf9\u665a\u671f\u5c3f\u8def\u4e0a\u76ae\u764c\uff08UC\uff09\u3001\u80be\u764c\u548c\u524d\u5217\u817a\u764c\u7684\u514d\u75ab\u6cbb\u7597\u8fdb\u884c\u4e86\u56fd\u5185\u5916\u7814\u7a76\u8fdb\u5c55\u4ecb\u7ecd\uff0c\u5305\u62ec\u5355\u836f\u548c\u8054\u5408\u6cbb\u7597\u7684\u5b9e\u9a8c\uff0c\u4ece\u4e00\u7ebf\u5230\u4e8c\u7ebf\u5404\u4e2aPD-1\/PD-L1\u4e34\u5e8a\u8bd5\u9a8c\u8fdb\u884c\u4e86\u6c47\u603b\uff0cDANUBE\u7814\u7a76\u7684\u8054\u5408\u4e00\u7ebf\u6cbb\u7597\u8fdb\u5c55\uff0c\u4ee5\u53ca5\u79cdPD-1\/PD-L1\u7684\u4e8c\u7ebf\u6cbb\u7597\u3002<\/div>\n
\u00a0<\/div>\n
\u891a\u5029\u6559\u6388 \uff1a\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u9644\u5c5e\u540c\u6d4e\u533b\u9662\u80f8\u90e8\u80bf\u7624\u79d1\u526f\u4e3b\u4efb<\/div>\n
\u9898\u76ee\uff1a\u300a\u80ba\u764c\u7cbe\u51c6\u514d\u75ab\u6cbb\u7597\u63a2\u7d22\u4e0e\u601d\u8003\u300b<\/div>\n
\u891a\u6559\u6388\u4ee5\u80ba\u764c\u4e3a\u4f8b\uff0c\u4ecb\u7ecd\u4e86\u7cbe\u51c6\u8bca\u65ad\u751f\u7269\u6807\u5fd7\u7269\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u56e0\u7d20\uff0c\u8054\u5408\u6807\u5fd7\u7269\u68c0\u6d4b\u662f\u4f18\u5316\u60a3\u8005\u9009\u62e9\u7684\u8d8b\u52bf\uff0c\u901a\u8fc7\u4e34\u5e8a\u6570\u636e\uff0c\u5206\u5b50\u6570\u636e\u548c\u8868\u6027\u7279\u5f81\u6570\u636e\u8054\u5408\u5206\u6790\u6765\u9884\u6d4b\u7597\u6548\uff0c\u4e3a\u7cbe\u51c6\u6cbb\u7597\u63d0\u4f9b\u652f\u6301\uff0c\u901a\u8fc7\u7cbe\u51c6\u8bc4\u4f30\u505a\u597d\u60a3\u8005\u7684\u5168\u7a0b\u7ba1\u7406\u3002\u5982ctDNA\u7ed3\u5408\u5f71\u50cf\u5b66\u6765\u9884\u6d4b\u3001\u76d1\u6d4b\u75be\u75c5\u8fdb\u5c55\u60c5\u51b5\u3002<\/div>\n
\u00a0<\/div>\n
\u5218\u6653\u6674\u6559\u6388 \uff1a\u89e3\u653e\u519b307\u533b\u9662\u5168\u519b\u80bf\u7624\u4e2d\u5fc3\u80ba\u90e8\u80bf\u7624\u79d1\u4e3b\u4efb\u533b\u5e08\u3001CSCO\u7406\u4e8b<\/div>\n
\u9898\u76ee\uff1a\u300a\u80ba\u764c\u514d\u75ab\u8054\u5408\u6cbb\u7597\u300b<\/div>\n
\u5218\u6559\u6388\u5bf9\u80ba\u764c\u7684\u514d\u75ab\u8054\u5408\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u5404\u4e2a\u73af\u8282\u7684\u5173\u952e\u95ee\u9898\u8fdb\u884c\u4e86\u6982\u8ff0\uff0c\u7740\u91cd\u5bf9\u80ba\u764cPD-1\/PD-L1\u6291\u5236\u5242\u8054\u5408\u6cbb\u7597\u7684\u5fc5\u8981\u6027\u3001\u4e34\u5e8a\u5b9e\u9a8c\u57fa\u7840\u548c\u8054\u5408\u7684\u65f6\u673a\u3001\u6cbb\u7597\u65b9\u6848\u7b49\u95ee\u9898\u8fdb\u884c\u4e86\u8be6\u7ec6\u7684\u9610\u8ff0\u3002<\/div>\n
\u540c\u65f6\uff0c\u5218\u6559\u6388\u8868\u793a\u8054\u5408\u5316\u7597\u53ef\u4ee5\u8bf1\u5bfc\u65b0\u6297\u539f\u7684\u751f\u6210\uff0c\u8054\u5408\u653e\u7597\u53ef\u4ee5\u523a\u6fc0\u653e\u7597\u7684\u8fdc\u9694\u6548\u5e94\uff0c\u8054\u5408\u5206\u5b50\u9776\u5411\u6cbb\u7597\u4ee5\u53caIO\u8054\u5408IO\u7b49\u7684\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u3002<\/div>\n\n
\n![\"RmFicvQBAkgBCbSiblWf7OQliaI3xaKuGFpOsusVmf8icg6F2WviccaGuepcYZ0u0yvuoj599dCsKZYc6oNRibBuKd1A\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBCbSiblWf7OQliaI3xaKuGFpOsusVmf8icg6F2WviccaGuepcYZ0u0yvuoj599dCsKZYc6oNRibBuKd1A.jpeg\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n<\/div>\n
\u4e3a\u4e86\u63d0\u9ad8\u514d\u75ab\u836f\u7269\u7684\u6709\u6548\u7387\uff0c\u5bfb\u627e\u5408\u9002\u7684\u8054\u5408\u7b56\u7565\u6216\u514d\u75ab\u6807\u5fd7\u7269\u662f\u76ee\u524d\u7684\u7814\u7a76\u91cd\u70b9\uff0c\u800c\u68c0\u6d4b\u65b9\u6cd5\u7f3a\u4e4f\u7edf\u4e00\u6807\u51c6\u3001\u68c0\u6d4b\u6807\u5fd7\u7269\u591a\u6837\u6027\u3001\u7f3a\u4e4f\u6709\u6548\u6570\u636e\u7684\u79ef\u7d2f\u53ca\u5927\u6570\u636e\u7684\u5206\u6790\u6316\u6398\u7b49\u7b49\uff0c\u8fd9\u4e9b\u90fd\u662f\u76ee\u524d\u5b58\u5728\u7684\u95ee\u9898\uff0c\u8fd9\u9700\u8981\u4e34\u5e8a\u4e13\u5bb6\u3001\u836f\u7269\u7814\u53d1\u4e13\u5bb6\u3001\u6570\u636e\u5206\u6790\u4e13\u5bb6\u4ee5\u53ca\u57fa\u56e0\u68c0\u6d4b\u4e13\u5bb6\u7684\u591a\u9886\u57df\u901a\u529b\u5408\u4f5c\u3002<\/div>\n
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