{"id":9714,"date":"2018-04-16T23:14:46","date_gmt":"2018-04-16T15:14:46","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&mid=100004409&idx=1&sn=45c088c75df4fdf45746c9ec3c960c30&chksm=6b72a08e5c0529983cebce44dcb4b3a6b81645e49bf8992abfbd83134f1310b4c4de2b6828a4#rd"},"modified":"2026-04-02T19:17:54","modified_gmt":"2026-04-02T11:17:54","slug":"484850","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2018\/04\/16\/484850\/","title":{"rendered":"\u3010\u57fa\u56e0\u6167\u5468\u62a5\u3011\u4e2d\u56fd\u7684CAR-T\u548cCRISPR\u4e34\u5e8a\u8bd5\u9a8c\u603b\u6570\u9886\u5148\u4e16\u754c"},"content":{"rendered":"

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\u76f8\u5173\u94fe\u63a5\uff1a2018\u5e74\u57fa\u56e0\u884c\u4e1a\u521b\u6295\u62a5\u544a<\/a>\u00a0\u00a0|\u00a0 \u00a0\u5b89\u6c38\u62a5\u544a\uff1a2018\u5e74\u751f\u547d\u79d1\u5b66\u9886\u57df\u8fce\u6765\u5e76\u8d2d<\/a><\/div>\n
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\u56fe\uff0c\u6765\u81eaCellectis\u5b98\u7f51<\/div>\n
\u00b7\u00a0Cellectis<\/div>\n
\u5b9a\u4f4d\uff1a\u57fa\u56e0\u7f16\u8f91\u548c\u514d\u75ab\u7597\u6cd5<\/div>\n
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\"RmFicvQBAkgBEopQTOtVGgYQYEkIbxdpDibHRPOh7wEXRhINIbssjouWPqaf8b9eQgpfZbmcnVCjiaGUfEFby6kWQ\"\/<\/figure><\/div>\n\n
\u56fe\uff0c\u5168\u7403CAR-T\u7597\u6cd5\u7814\u7a76\u6570\u91cf\u7edf\u8ba1\uff0c\u6765\u81eaGoldman Sachs IR\uff1bclinicaltrials.gov\uff0c\u6570\u636e\u7edf\u8ba1\u622a\u6b622018\u5e742\u6708<\/div>\n
\u636e\u9ad8\u76db\u7edf\u8ba1\u5206\u6790\uff0c\u53bb\u5e74\uff0c\u4e2d\u56fd\u67099\u9879CRISPR\u7f16\u8f91\u8bd5\u9a8c\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76\u4ee5\u6cbb\u7597\u4e2d\u56fd\u764c\u75c7\u548c\u827e\u6ecb\u75c5\u60a3\u8005\uff0c\u800c\u7f8e\u56fd\u53ea\u6709\u4e00\u9879\u7814\u7a76\uff0c\u5e76\u4e14\u4e2d\u56fd\u73b0\u670980\u591a\u540d\u60a3\u8005\u6b63\u5728\u63a5\u53d7\u8fd9\u4e9b\u57fa\u56e0\u836f\u7269\u7684\u6cbb\u7597\u3002\u53bb\u5e74\uff0c\u4e2d\u56fd\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u4f1a\u4e3a\u8d85\u8fc790\u4e2aCRISPR\u9879\u76ee\u63d0\u4f9b\u4e86\u8d44\u91d1\uff0c\u5728\u8fc7\u53bb\u76844\u5e74\u4e2d\u8d85\u8fc7270\u4e2a\u3002\u7531\u4e8e\u6ca1\u6709\u5173\u4e8e\u57fa\u56e0\u7f16\u8f91\u8bd5\u9a8c\u7684\u660e\u6587\u89c4\u5b9a\uff0c\u4e2d\u56fd\u7684\u533b\u9662\u8fc5\u901f\u52a0\u901f\u5176CRISPR\u7814\u7a76\u53ca\u8bd5\u9a8c\u5de5\u4f5c\uff0c\u9ad8\u76db\u9884\u8ba1\u8fd9\u79cd\u60c5\u51b5\u53ef\u80fd\u4f1a\u5f88\u5feb\u53d1\u751f\u53d8\u5316\u3002\u540c\u65f6\uff0c\u4e2d\u56fd\u7684CAR-T\u7814\u7a76\u603b\u6570\u5df2\u63a5\u8fd1\u7f8e\u56fd\u3002\u622a\u81f32\u6708\uff0c\u4e2d\u56fd\u7684CAR-T\u8bd5\u9a8c\u603b\u6570\u4e3a153\u6b21\uff0c\u7f8e\u56fd\u4e3a164\u6b21\uff0c\u6b27\u6d32\u4e3a73\u6b21\uff0c\u5176\u4ed6\u5730\u533a\u4e3a56\u6b21\u3002<\/div>\n
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1. \u6b66\u6c49\u5927\u5b66\u4e2d\u5357\u533b\u9662\uff1a ddPCR\u9ad8\u7075\u654f\u68c0\u6d4b\u4e59\u809d<\/div>\n
\u6b66\u6c49\u5927\u5b66\u4e2d\u5357\u533b\u9662\u57fa\u56e0\u8bca\u65ad\u4e2d\u5fc3\u7814\u53d1\u51faddPCR\u65b0\u578bHBV\u68c0\u6d4b\u65b9\u6cd5\uff0c\u5bf9\u68c0\u6d4b\u75d5\u91cf\u5206\u5b50\u5982\u75c5\u6bd2\u5177\u6709\u9ad8\u7075\u654f\u5ea6\u548c\u51c6\u786e\u6027\uff0c\u53ef\u4ee5\u68c0\u6d4b\u8840\u6e05\u4e2d\u7684cccDNA\u3002\u7814\u7a764\u670812\u65e5\u53d1\u8868\u4e8e\u300aThe Journal of Molecular Diagnostics\u300b\u3002<\/div>\n
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2.\u4ea8\u5ef7\u987f\u821e\u8e48\u75c5\u6cbb\u7597\u65b0\u601d\u8def\uff1a\u51cf\u5c11\u8111\u7ebf\u7c92\u4f53\u94c1\u7684\u5bcc\u96c6<\/div>\n
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\u00a0<\/div>\n
3.CSE1L\u662f\u7ef4\u6301 DNA \u7532\u57fa\u5316\u57fa\u56e0\u6c89\u9ed8\u5fc5\u9700\u86cb\u767d<\/div>\n
4\u670810\u65e5\uff0c\u300aPNAS\u300b\u53d1\u8868\u4e2d\u79d1\u9662\u751f\u7269\u7269\u7406\u6240\u7814\u7a76\u6210\u679c\uff0c\u53d1\u73b0CSE1L\u4f5c\u4e3a\u7ec6\u80de\u4e2d\u7ecf\u5178\u5165\u6838\u8f6c\u8fd0\u9014\u5f84\u4e2d\u7684\u91cd\u8981\u86cb\u767d\uff0c\u662f\u7ef4\u6301\u90e8\u5206\u7532\u57fa\u5316\u57fa\u56e0\u6c89\u9ed8\u6240\u5fc5\u9700\u7684\uff0c\u8fdb\u4e00\u6b65\u63ed\u793a\u901a\u8fc7\u9009\u62e9\u6027\u5730\u8f6c\u8fd0\u7279\u5b9a\u9776\u86cb\u767d\u5165\u6838\u6765\u7ef4\u6301\u57fa\u56e0\u6c89\u9ed8\u7684\u751f\u7269\u5b66\u673a\u5236\u3002<\/div>\n
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4.\u7b49\u4f4d\u57fa\u56e0FGF21\u4e0e\u4f53\u8102\u4e0b\u964d\u3001\u8840\u538b\u5347\u9ad8\u76f8\u5173<\/div>\n
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\u00a0<\/div>\n
5. \u6df1\u5733\u5148\u8fdb\u9662\u7814\u53d1\u51fa\u80ce\u76d8\u9776\u5411\u836f\u7269\u6295\u9012\u65b0\u5de5\u5177<\/div>\n
\u4e2d\u79d1\u9662\u6df1\u5733\u5148\u8fdb\u6280\u672f\u7814\u7a76\u9662\u4e0e\u97e6\u6069\u5dde\u7acb\u5927\u5b66\u533b\u5b66\u9662\u5408\u4f5c\uff0c\u7814\u53d1\u51fa\u80ce\u76d8\u9776\u5411\u7eb3\u7c73\u9897\u7c92\uff0c\u5b9e\u73b0\u7279\u5f02\u6027\u5730\u5c06\u836f\u7269\u6295\u9012\u5230\u80ce\u76d8\u6ecb\u517b\u5c42\uff0c\u907f\u514d\u4e86\u836f\u7269\u7684\u6bd2\u526f\u4f5c\u7528\uff0c\u4e3a\u5f00\u53d1\u6cbb\u7597\u80ce\u76d8\u6e90\u6027\u75be\u75c5\u836f\u7269\u63d0\u4f9b\u4e86\u6709\u6548\u5de5\u5177\u3002\u7814\u7a764\u670810\u65e5\u53d1\u8868\u5728\u300aTheranostics\u300b\u3002<\/div>\n
\u00a0<\/div>\n
6. \u590d\u65e6\u9996\u6b21\u7ed8\u5236\u4e2d\u56fd\u4e73\u817a\u764c\u76f8\u5173\u901a\u8def\u57fa\u56e0\u7a81\u53d8\u8c31<\/div>\n
\u590d\u65e6\u7814\u7a76\u56e2\u961f\u9996\u6b21\u7ed8\u5236\u51faPI3K\/AKT\u901a\u8def\u5728\u4e2d\u56fd\u4e73\u817a\u764c\u60a3\u8005\u4e2d\u7684\u57fa\u56e0\u7a81\u53d8\u8c31\uff0c\u786e\u5b9a\u4e86\u4e2d\u56fd\u4e73\u817a\u764c\u60a3\u8005\u4e2dPIK3CA\u3001PIK3R1\u3001AKT3\u548cPTEN\u53d1\u751f\u4f53\u7ec6\u80de\u7a81\u53d8\u666e\u904d\u4e14\u591a\u6837\u5316\uff0c\u5e76\u9274\u5b9a\u4e8660\u4e2a\u65b0\u7a81\u53d8\u3002\u5bf9PI3K\u9776\u5411\u6cbb\u7597\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u7814\u7a764\u670811\u65e5\u53d1\u8868\u5728\u300aNature Communications\u300b\u3002<\/div>\n
\u00a0<\/div>\n
7. \u7f3a\u4e4f\u7ebf\u7c92\u4f53\u86cb\u767dOpa1\u5c06\u5bfc\u81f4\u4e25\u91cd\u708e\u75c7<\/div>\n
\u5df4\u585e\u7f57\u90a3\u751f\u7269\u533b\u5b66\u7814\u7a76\u6240\uff08IRB\uff09\u7814\u7a76\u53d1\u73b0\uff0c\u5728\u5c0f\u9f20\u808c\u8089\u4e2d\u53bb\u9664\u7ebf\u7c92\u4f53\u86cb\u767dOpa1\u4f1a\u5bfc\u81f4\u6574\u4e2a\u8eab\u4f53\u53d1\u751f\u4e25\u91cd\u708e\u75c7\uff0c\u6700\u7ec8\u5bfc\u81f4\u8fc7\u65e9\u6b7b\u4ea1\u3002Opa1\u53c2\u4e0e\u7ebf\u7c92\u4f53\u5185\u819c\u878d\u5408\u548c\u5d74\u7684\u5f62\u6210\u3002\u7814\u7a764\u670810\u65e5\u53d1\u8868\u4e8e\u300aThe EMBO Journal\u300b\u3002<\/div>\n
\u00a0<\/div>\n
8. \u300aCell\u300b\u5b50\u520a\uff1a\u751f\u7269\u6807\u5fd7\u7269\u53ef\u9884\u6d4b\u6076\u6027\u80f6\u8d28\u7624\u590d\u53d1\u98ce\u9669<\/div>\n
Henry Ford Health System\u7814\u7a76\u5c0f\u7ec4\u901a\u8fc7\u5bf977\u540d\u60a3\u8005\u7684\u5f25\u6f2b\u6027\u80f6\u8d28\u7624\u8fdb\u884cDNA\u7532\u57fa\u5316\u5206\u6790\uff0c\u786e\u5b9a\u4e86\u5177\u4f53\u7684\u9884\u6d4b\u6027\u751f\u7269\u6807\u5fd7\u7269\uff0c\u53ef\u4ee5\u5e2e\u52a9\u8bc4\u4f30\u6076\u6027\u80f6\u8d28\u7624\u60a3\u8005\u590d\u53d1\u98ce\u9669\u7684\u9ad8\u4f4e\u3002\u7814\u7a764\u670811\u65e5\u53d1\u8868\u4e8e\u300aCell Report\u300b\u3002<\/div>\n
\u00a0<\/div>\n
9.\u00a0ALS\u4e0eFTD\u7b49\u4e24\u79cd\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u6709\u57fa\u56e0\u91cd\u53e0<\/div>\n
\u52a0\u5229\u798f\u5c3c\u4e9a\u5927\u5b66\u7814\u7a76\u4eba\u5458\u7814\u7a76\u8fd1125000\u4e2a\u6b27\u6d32\u75c5\u4f8b\u548c\u5bf9\u7167\u53d1\u73b0\uff0c\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\uff08ALS\uff09\u4e0e\u81f3\u5c11\u4e24\u79cd\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e4b\u95f4\u5b58\u5728\u4e00\u4e9b\u57fa\u56e0\u91cd\u53e0\uff1a\u989d\u989e\u53f6\u75f4\u5446\uff08FTD\uff09\u548c\u8fdb\u884c\u6027\u6838\u4e0a\u6027\u9ebb\u75f9\uff08PSP\uff09\u3002\u7814\u7a764\u670810\u65e5\u53d1\u8868\u4e8e\u300aJAMA Neurology\u300b<\/div>\n
\u00a0<\/div>\n
10. \u57fa\u56e0\u6d4b\u5e8f\u786e\u5b9a40\u4e2a\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u75c5\u76f8\u5173\u57fa\u56e0<\/div>\n
\u4f26\u6566\u764c\u75c7\u7814\u7a76\u6240\u7684\u7814\u7a76\u4eba\u5458\u68c0\u6d4b\u4e86765\u4f8b\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u7684\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6570\u636e\uff0c\u786e\u5b9a\u4e8640\u4e2a\u76f8\u5173\u57fa\u56e0\uff0c\u5305\u62ec11\u4e2a\u5019\u9009\u57fa\u56e0\uff0c\u4f8b\u5982IRF4\u548cPRDM1\u7b49\u6d46\u7ec6\u80de\u5206\u5316\u7684\u91cd\u8981\u57fa\u56e0\u3002\u8fd8\u53d1\u73b0NBPF1\u6216\u662f\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u53d1\u751f\u7684\u65b0\u5019\u9009\u57fa\u56e0\u3002\u7814\u7a764\u670810\u65e5\u53d1\u8868\u4e8e\u300aLeukemia\u300b \u3002\u00a0<\/div>\n
\u00a0<\/div>\n
11.\u300aNature\u300b\uff1a\u9ad8\u8868\u8fbe\u7aef\u7c92\u9176\u7684\u5e72\u7ec6\u80de\u53ef\u518d\u751f\u809d\u810f<\/div>\n
\u7f8e\u56fd\u65af\u5766\u798f\u5927\u5b66\u533b\u5b66\u9662\u6700\u65b0\u53d1\u73b0\uff0c\u4e00\u79cd\u8868\u8fbe\u9ad8\u6c34\u5e73\u7aef\u7c92\u9176\u7684\u5e72\u7ec6\u80de\u53ef\u4ee5\u4fee\u590d\u809d\u810f\u3002\u5c0f\u9f20\u4f53\u5185\u6240\u6709\u809d\u7ec6\u80de\u76843% -5\uff05\u7531\u809d\u5e72\u7ec6\u80de\u7ec4\u6210\uff0c\u5e72\u7ec6\u80de\u901a\u8fc7\u809d\u5c0f\u53f6\u5747\u5300\u5206\u5e03\uff0c\u5728\u6b63\u5e38\u7ec6\u80de\u66f4\u65b0\u671f\u95f4\u548c\u809d\u635f\u4f24\u53d1\u751f\u540e\uff0c\u5728\u9002\u5f53\u4f4d\u7f6e\u589e\u6b96\u4ee5\u5f62\u6210\u65b0\u7684\u809d\u7ec6\u80de\u56e2\u5757\u3002\u7814\u7a764\u67085\u65e5\u53d1\u8868\u4e8e\u300aNature\u300b \u3002<\/div>\n
\u00a0<\/div>\n
12.\u63ed\u79d8\u6c34\u7a3b\u9000\u5316\u9057\u4f20\u673a\u5236\uff1a\u82f9\u679c\u9178\u52a9\u529b\u6c34\u7a3b\u589e\u4ea7<\/div>\n
\u4e2d\u56fd\u519c\u4e1a\u79d1\u5b66\u9662\u6700\u65b0\u7814\u7a76\u63ed\u793a\u4e86\u6c34\u7a3b\u7a57\u9876\u90e8\u5c0f\u82b1\u9000\u5316\u7684\u9057\u4f20\u548c\u5206\u5b50\u673a\u7406\uff0c\u7814\u7a76\u8868\u660e\u82f9\u679c\u9178\u6291\u5236\u6c34\u7a3b\u7a57\u9876\u90e8\u9000\u5316\u548cOsALMT7\u8f6c\u8fd0\u82f9\u679c\u9178\u5728\u6c34\u7a3b\u5e7c\u7a57\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u8d77\u4f5c\u7528\u7684\u5206\u5b50\u673a\u5236\u3002\u7814\u7a76\u8fd1\u65e5\u53d1\u8868\u5728\u300aPlant Cell\u300b\u3002<\/div>\n
\u00a0<\/div>\n
13.\u300a\u67f3\u53f6\u5200\u300b\u5b50\u520a\uff1a\u65b0\u514d\u75ab\u7597\u6cd5\u7ec4\u5408\u63a7\u5236\u80ba\u764c\u53d1\u5c55<\/div>\n
\u5357\u5361\u7f57\u83b1\u7eb3\u533b\u79d1\u5927\u5b66Hollings\u764c\u75c7\u4e2d\u5fc3\u6700\u65b0\u7814\u7a76\u53d1\u73b0\u4e00\u79cd\u65b0\u7684\u514d\u75ab\u6cbb\u7597\u7ec4\u5408\u5728\u63a7\u5236\u80ba\u764c\u53d1\u5c55\u65b9\u9762\u5177\u6709\u663e\u8457\u7597\u6548\uff1a\u68c0\u67e5\u70b9\u836f\u7269nivolumab\u4e0e\u65b0\u578b\u5f3a\u529b\u514d\u75ab\u523a\u6fc0\u836f\u7269ALT-803\u7684\u7ec4\u5408\u3002\u6b64\u524d\u4ece\u672a\u5728\u4eba\u7c7b\u8bd5\u9a8c\u4e2d\u7ec4\u5408\u4f7f\u7528\u8fc7\uff0c\u4e14\u8bd5\u9a8c\u8868\u660e\u8fd9\u4e9b\u836f\u7269\u53ef\u4ee5\u5b89\u5168\u7ed9\u836f\u3002\u7814\u7a764\u67086\u65e5\u53d1\u8868\u4e8e\u300a\u67f3\u53f6\u5200\u80bf\u7624\u5b66\u300b\u3002<\/div>\n
\u00a0<\/div>\n
14.\u300aCell\u300b\u5b50\u520a\uff1a79\u5c81\u9ad8\u9f84\u8001\u4eba\u4ecd\u62e5\u6709\u65b0\u751f\u795e\u7ecf\u5143<\/div>\n
\u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\u56e2\u961f\u901a\u8fc7\u5206\u6790\u5e74\u9f84\u4ecb\u4e8e14\uff5e79\u5c81\u95f4\u768428\u4f4d\u5065\u5eb7\u4eba\u5927\u8111\uff0c\u53d1\u73b0\u8001\u5e74\u4eba\u7684\u6d77\u9a6c\u533a\u62e5\u6709\u4e0e\u5e74\u8f7b\u4eba\u4e00\u6837\u7531\u7956\u7ec6\u80de\uff08progenitor cell\uff09\u5236\u9020\u6570\u5343\u4e2a\u65b0\u795e\u7ecf\u5143\u7684\u80fd\u529b\u3002\u7814\u7a764\u67085\u65e5\u53d1\u5e03\u5728\u300aCell Stem Cell\u300b\u3002<\/div>\n
\u00a0<\/div>\n
15.\u300aNature\u300b\uff1a\u6291\u5236PFKFB4\u548cSRC-3\u53ef\u6d88\u9664\u80bf\u7624\u589e\u957f\u548c\u8f6c\u79fb<\/div>\n
\u8d1d\u52d2\u533b\u5b66\u9662\u548cRoswell Park\u7efc\u5408\u764c\u75c7\u4e2d\u5fc3\u6700\u65b0\u7814\u7a76\u8868\u660e\uff0c\u7cd6\u9175\u89e3\u8fc7\u7a0b\u7684\u5173\u952e\u679c\u7cd6\u6fc0\u9176 PFKFB4\u53ef\u4ee5\u4f5c\u7528\u4e8e\u8f6c\u5f55\u6fc0\u6d3b\u86cb\u767d SRC-3\uff0c\u589e\u52a0\u8f6c\u5f55\u6d3b\u6027\uff0c\u8fdb\u800c\u4fc3\u8fdb\u4e73\u817a\u764c\u7ec6\u80de\u589e\u6b96\u548c\u8f6c\u79fb\u3002\u7814\u7a764\u67084\u65e5\u53d1\u8868\u4e8e\u300aNature\u300b\u3002<\/div>\n
\u76f8\u5173\u94fe\u63a5\uff1a\u00a0\u00a0\u5e74\u5ea6\u76d8\u70b9-\u6280\u672f\u7bc7<\/a>\u00a0\u00a0\u00a0|\u00a0\u00a0\u79d1\u7814\u7bc7\u4e13\u8bbf\u5408\u96c6\u00a0\u00a0|\u00a0<\/a>\u00a0\u9b4f\u4e8e\u5168<\/a>\u00a0\u00a0\u00a0|\u00a0\u00a0\u8d75\u7acb\u5e73<\/a>\u00a0\u00a0|\u00a0\u00a0\u83e0\u841d<\/a>\u00a0\u00a0\u00a0|\u00a0\u00a0\u5b59\u7acb\u82f1\u00a0\u00a0|\u00a0\u00a0<\/a>14\u4f4d\u5b66\u8005\u5927\u5496\u91c7\u8bbf\u5408\u96c6<\/a>\u00a0\u00a0|\u00a0\u00a027\u4f4d\u4e34\u5e8a\u5927\u5496\u91c7\u8bbf\u5408\u96c6<\/a><\/div>\n
\u00a0<\/div>\n
\u5229\u597d\u653f\u7b56<\/div>\n\n
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\"RmFicvQBAkgCqbYgVOZQOQAlibTiaGLEn5X9s1Haohia05xNiaEUMaZ4eDkZibhcmdYvsohfkBvQ1ZVheNJ7SeYic62ibA\"\/<\/figure><\/div>\n\n
\u56fe\uff0c\u6765\u81ea\u7f51\u7edc<\/div>\n
1.\u00a0\u56fd\u52a1\u9662\uff1a5\u67081\u65e5\u8d77\uff0c\u8fdb\u53e3\u6297\u764c\u836f\u96f6\u5173\u7a0e<\/div>\n
\u56fd\u52a1\u9662\u674e\u603b\u74064\u670812\u65e5\u4e3b\u6301\u53ec\u5f00\u56fd\u52a1\u9662\u5e38\u52a1\u4f1a\u8bae\uff0c\u4ece5\u67081\u65e5\u8d77\uff0c\u51b3\u5b9a\u5bf9\u8fdb\u53e3\u6297\u764c\u836f\u5b9e\u65bd\u96f6\u5173\u7a0e\uff0c\u9f13\u52b1\u521b\u65b0\u836f\u8fdb\u53e3\u3002<\/div>\n
\u00a0<\/div>\n
2.\u00a0\u56fd\u52a1\u9662\uff1a\u52a0\u5feb\u53d1\u5c55\u201c\u4e92\u8054\u7f51+\u533b\u7597\u5065\u5eb7\u201d<\/div>\n
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\u00a0<\/div>\n
3.\u00a0\u7f8e\u56fdFDA\uff1a\u4e24\u9879NGS\u6307\u5bfc\u65b9\u9488\uff0c\u63a8\u8fdb\u4e2a\u6027\u5316\u7597\u6cd5<\/div>\n
4\u670813\u65e5\uff0c\u7f8e\u56fdFDA\u9881\u5e03\u4e24\u9879NGS\u6307\u5bfc\u65b9\u9488\uff0c\u65e8\u5728\u63a8\u52a8\u4e0b\u4e00\u4ee3\u6d4b\u5e8f\uff08NGS\uff09\u6280\u672f\u7684\u9ad8\u6548\u5f00\u53d1\uff0c\u5c06\u5728\u6301\u7eed\u63a8\u8fdb\u4e2a\u6027\u5316\u57fa\u56e0\u8bca\u7597\u65b9\u9762\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002\u5176\u4e2d\u4e00\u4efd\u6307\u5357\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b9\u6cd5\uff0c\u7814\u53d1\u8005\u53ef\u4ee5\u4f7f\u7528FDA\u8ba4\u53ef\u7684\u516c\u5171\u6570\u636e\u5e93\u7684\u4e34\u5e8a\u8bc1\u636e\u6765\u4fdd\u8bc1\u57fa\u56e0\u7ec4\u6d4b\u8bd5\u7ed3\u679c\u7684\u51c6\u786e\u4e34\u5e8a\u8bc4\u4f30\uff1b\u53e6\u4e00\u4efd\u6307\u5357\u63d0\u4f9b\u4e86\u8bbe\u8ba1\u3001\u7814\u53d1\u3001\u9a8c\u8bc1\u57fa\u4e8eNGS\u7684\u8bca\u65ad\u7591\u4f3c\u9057\u4f20\u75be\u75c5\u4e2a\u4f53\u7684\u68c0\u6d4b\u3002<\/div>\n
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5.\u00a0\u6df1\u5733\u76d0\u7530\u533a\u5c45\u6c11\u514d\u8d39\u57fa\u56e0\u68c0\u6d4b\u5b9e\u73b0\u5168\u8986\u76d6<\/div>\n
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\u00a0<\/div>\n
6.\u00a0\u6559\u80b2\u90e8\u5370\u53d1\u300a\u9ad8\u7b49\u5b66\u6821\u4eba\u5de5\u667a\u80fd\u521b\u65b0\u884c\u52a8\u8ba1\u5212\u300b<\/div>\n
\u6559\u80b2\u90e84\u67083\u65e5\u5236\u5b9a\u5e76\u53d1\u5e03\u300a\u9ad8\u7b49\u5b66\u6821\u4eba\u5de5\u667a\u80fd\u521b\u65b0\u884c\u52a8\u8ba1\u5212\u300b\u3002\u5236\u5b9a\u4e86\u4ece2020\u5e74\u52302025\u5e74\u30012030\u5e74\u7684\u201c\u4e09\u6b65\u8d70\u201d\u89c4\u5212\u3002\u52302030\u5e74\uff0c\u9ad8\u6821\u6210\u4e3a\u5efa\u8bbe\u4e16\u754c\u4e3b\u8981\u4eba\u5de5\u667a\u80fd\u521b\u65b0\u4e2d\u5fc3\u7684\u6838\u5fc3\u529b\u91cf\u548c\u5f15\u9886\u65b0\u4e00\u4ee3\u4eba\u5de5\u667a\u80fd\u53d1\u5c55\u7684\u4eba\u624d\u9ad8\u5730\uff0c\u4e3a\u6211\u56fd\u8dfb\u8eab\u521b\u65b0\u578b\u56fd\u5bb6\u524d\u5217\u63d0\u4f9b\u79d1\u6280\u652f\u6491\u548c\u4eba\u624d\u4fdd\u969c\u3002<\/div>\n
\u00a0<\/div>\n
7.\u00a0\u56fd\u5bb6\u5e02\u573a\u76d1\u7763\u7ba1\u7406\u603b\u5c40\u6b63\u5f0f\u6302\u724c<\/div>\n
4\u670810\u65e5\uff0c\u65b0\u7ec4\u5efa\u7684\u56fd\u5bb6\u5e02\u573a\u76d1\u7763\u7ba1\u7406\u603b\u5c40\u6b63\u5f0f\u6302\u724c\u3002\u5f20\u8305\u4efb\u5c40\u957f\uff0c\u6bd5\u4e95\u6cc9\u4efb\u515a\u59d4\u4e66\u8bb0\u3002\u540c\u65f6\uff0c\u539f\u56fd\u5bb6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u603b\u5c40\uff08CFDA\uff09\u5b98\u7f51\u66f4\u540d\u4e3a\u56fd\u5bb6\u5e02\u573a\u76d1\u7763\u7ba1\u7406\u603b\u5c40\u3002<\/div>\n
\u76f8\u5173\u94fe\u63a5\uff1a\u00a0\u00a0\u5e74\u5ea6\u76d8\u70b9-\u653f\u7b56\u7bc7<\/a>\u00a0\u00a0\u00a0|\u00a0<\/a>\u00a0\u57fa\u56e0+\u4fdd\u9669<\/a><\/div>\n
\u00a0<\/div>\n
\u4ea7\u4e1a\u98ce\u5411<\/div>\n\n
\n
\"?wx_fmt=png\"\/<\/figure><\/div>\n\n
\u56fe\uff0c\u6765\u81ea\u7f51\u7edc<\/div>\n
1.\u00a0\u9996\u6b3eAI\u68c0\u6d4b\u7cd6\u5c3f\u75c5\u60a3\u8005\u773c\u75be\u7684\u533b\u7597\u8bbe\u5907\u83b7\u6279\u4e0a\u5e02<\/div>\n
4\u670812\u65e5\uff0c\u7f8e\u56fdFDA\u6279\u51c6\u9996\u6b3e\u57fa\u4e8eAI\u7684\u68c0\u6d4b\u7cd6\u5c3f\u75c5\u60a3\u8005\u89c6\u7f51\u819c\u75c5\u53d8\u7684\u533b\u7597\u8bbe\u5907IDx-DR\u4e0a\u5e02\u3002\u5f53\u9ad8\u6c34\u5e73\u7684\u8840\u7cd6\u5bfc\u81f4\u89c6\u7f51\u819c\u8840\u7ba1\u7684\u5149\u654f\u7ec4\u7ec7\u635f\u4f24\u65f6\uff0c\u4f1a\u53d1\u751f\u7cd6\u5c3f\u75c5\u6027\u89c6\u7f51\u819c\u75c5\u53d8\uff0c\u5b83\u662f\u9996\u4e2a\u83b7\u5f97\u5e02\u573a\u8425\u9500\u6388\u6743\u53ef\u4ee5\u63d0\u4f9b\u51b3\u7b56\u7684\u8bbe\u5907\u3002<\/div>\n
\u00a0<\/div>\n
2.\u00a0Bionano\u548cGenoox\u5408\u4f5c\u7814\u53d1DNA\u7ed3\u6784\u53d8\u5f02\u68c0\u6d4b<\/div>\n
Genoox 4\u670812\u65e5\u5ba3\u5e03\uff0c\u5df2\u4e0e Bionano \u8fbe\u6210\u5408\u4f5c\uff0c\u7814\u53d1\u57fa\u56e0\u7ec4\u4fe1\u606f\u5de5\u4f5c\u6d41\u7a0b\uff0c\u8be5\u96c6\u6210\u5e73\u53f0\u5c06\u5b9e\u73b0\u591a\u79cd\u529f\u80fd\uff1a\u5728\u5355\u4e2a\u5e73\u53f0\u4e0a\u68c0\u6d4bSNV\u53d8\u5f02\u548c\u7ed3\u6784\u53d8\u5f02\uff1b\u4f7f\u7528 Genoox \u7684\u5e73\u53f0\u8fdb\u884c\u81ea\u52a8\u5904\u7406\uff0c\u6ce8\u91ca\uff0c\u6570\u636e\u96c6\u6210\u548c\u7ed3\u679c\u62a5\u544a\u3002<\/div>\n
\u00a0<\/div>\n
3.\u00a0Alexion\u8fd19\u4ebf\u7f8e\u5143\u6536\u8d2dWilson Therapeutics<\/div>\n
4\u670812\u65e5\uff0c\u9886\u5148\u7684\u7f55\u89c1\u75be\u75c5\u9886\u57df\u4f01\u4e1a Alexion \u5ba3\u5e03\u5c06\u65a5\u8d448.55\u4ebf\u7f8e\u5143\u6536\u8d2dWilson Therapeutics\uff0c\u8be5\u4ea4\u6613\u5c06\u63a8\u8fdb\u5176\u5019\u9009\u836f\u7269WTX101\u7684III\u671f\u7814\u53d1\uff0c\u8be5\u836f\u7269\u7528\u4e8e\u6cbb\u7597\u7f55\u89c1\u7684\u9057\u4f20\u6027\u809d\u75c5\u5a01\u5c14\u900a\u75c5\u3002<\/div>\n
\u00a0<\/div>\n
4 .Illumina\u548cLoxo\u5408\u4f5c\u7814\u53d1\u57fa\u4e8eNGS\u7684\u6cdb\u764c\u4f34\u968f\u8bca\u65ad<\/div>\n
4\u670811\u65e5\uff0cIllumina\u548cLoxo Oncology\uff08\u7b80\u79f0Loxo\uff09\u8fbe\u6210\u5408\u4f5c\uff0c\u5c06\u5171\u540c\u7814\u53d1\u548c\u5546\u4e1a\u5316\u57fa\u4e8eNGS\u7684\u6cdb\u764c\u4f34\u968f\u8bca\u65ad\u3002\u8fd9\u5c06\u4f7fIllumina\u7684TruSight Tumor 170\u68c0\u6d4b\u5e73\u53f0\u4f5c\u4e3aLoxo\u7684larotrectinib\u548c\u9776\u5411RET\u57fa\u56e0\u7684LOXO-292\u7684\u4f34\u968f\u8bca\u65ad\uff08CDx\uff09\u3002<\/div>\n
\u00a0<\/div>\n
5. PerkinElmer\u5c06\u5728Helix\u5728\u7ebf\u5e73\u53f0\u63a8\u51fa\u68c0\u6d4b59\u79cd\u57fa\u56e0\u7684\u4ea7\u54c1<\/div>\n
4\u670811\u65e5\uff0cPerkinElmer\u5ba3\u5e03\u4e0eHelix\u5408\u4f5c\u7814\u53d1\u5916\u663e\u5b50\u7ec4\u6d4b\u5e8f\uff0c\u5e76\u5c06\u5176\u5546\u4e1a\u5316\u3002PerkinElmer\u5c06\u5728Helix\u7684\u7ebf\u4e0a\u9500\u552e\u5e73\u53f0\u63a8\u51fa\u9996\u6b3e\u4ea7\u54c1\uff0c\u63d0\u4f9b\u7531American College of Medical Genetics and Genomics\uff08ACMG\uff09\u786e\u5b9a\u7684\u4e0e\u4e25\u91cd\u75be\u75c5\u76f8\u5173\u768459\u79cd\u57fa\u56e0\u81f4\u75c5\u6027\u53d8\u5f02\u7684\u68c0\u6d4b\u7ed3\u679c\u3002<\/div>\n
\u00a0<\/div>\n
6. Lonza\u5c06\u5f00\u8bbe\u8fd13\u4e07\u5e73\u7c73\u7684\u7ec6\u80de\u548c\u57fa\u56e0\u7597\u6cd5\u4e2d\u5fc3<\/div>\n
4\u670811\u65e5\uff0cLonza\u5ba3\u5e03\u5c06\u5efa\u8bbe\u9762\u79ef\u8fbe300,000\u5e73\u65b9\u82f1\u5c3a\uff0827,870\u5e73\u65b9\u7c73\uff09\u7684\u4e16\u754c\u9886\u5148\u7684\u7ec6\u80de\u548c\u57fa\u56e0\u7597\u6cd5\u7814\u53d1\u4e2d\u5fc3\u3002\u5c06\u5f15\u8fdb\u5927\u91cf\u5148\u8fdb\u7684\u751f\u4ea7\u8bbe\u5907\uff0c\u80fd\u591f\u4e3a\u6570\u5343\u540d\u60a3\u6709\u7f55\u89c1\u9057\u4f20\u75be\u75c5\u6216\u5a01\u80c1\u751f\u547d\u7684\u75be\u75c5\u7684\u60a3\u8005\u63d0\u4f9b\u6cbb\u7597\u3002<\/div>\n
\u00a0<\/div>\n
7.\u00a0\u5927\u767e\u6c47\u3001\u65b0\u534e\u8054\u3001\u7f8e\u5e74\u5927\u5065\u5eb7\u7b49\u5de8\u5934\u643a\u624b\u52a9\u63a8\u76d0\u7530\u5065\u5eb7\u4ea7\u4e1a\u53d1\u5c55<\/div>\n
4\u670810\u65e5\uff0c\u65b0\u534e\u8054\u96c6\u56e2\u8463\u4e8b\u5c40\u4e3b\u5e2d\u517c\u603b\u88c1\u5085\u519b\u3001\u7f8e\u5e74\u5927\u5065\u5eb7\u96c6\u56e2\u8463\u4e8b\u957f\u4fde\u7194\u3001\u56fd\u5bb6863\u8ba1\u5212\u4e13\u5bb6\u7ec4\u7ec4\u957f\u674e\u78ca\u3001\u5927\u767e\u6c47\u96c6\u56e2\u8463\u4e8b\u957f\u6e29\u7eaf\u9752\u3001\u603b\u88c1\u6e29\u80b2\u9752\u7b49\u9f50\u805a\u5927\u767e\u6c47\u603b\u90e8\uff0c\u56f4\u7ed5\u4e2d\u56fd\u5e72\u7ec6\u80de\u548c\u518d\u751f\u533b\u5b66\u7684\u7814\u7a76\u4e0e\u5e94\u7528\u3001\u6df1\u5733\u53ca\u76d0\u7530\u533a\u5927\u5065\u5eb7\u4ea7\u4e1a\u524d\u666f\u53ca\u53d1\u5c55\u89c4\u5212\u3001\u7ec4\u5efa\u533b\u7597\u4ea7\u4e1a\u57fa\u91d1\u7b49\u8bae\u9898\u5c55\u5f00\u6df1\u5165\u63a2\u8ba8\u5e76\u4e00\u81f4\u8fbe\u6210\u5408\u4f5c\u610f\u89c1\u3002\u5404\u65b9\u5c06\u5171\u540c\u53d1\u8d77\u6210\u7acb20\u4ebf\u5143\u533b\u7597\u4ea7\u4e1a\u57fa\u91d1\uff0c\u91cd\u70b9\u6295\u8d44\u5b75\u5316\u533b\u7597\u5065\u5eb7\u751f\u6001\u5168\u94fe\u6761\u7684\u4f18\u8d28\u9879\u76ee\u548c\u4f01\u4e1a\u3002<\/div>\n
\u00a0<\/div>\n
8.GEN\uff1a\u76d8\u70b9\u5168\u7403\u6d4b\u5e8f\u884c\u4e1a10\u5927\u5de8\u5934<\/div>\n
4\u670810\u65e5\uff0cGEN\u7f51\u7ad9\u76d8\u70b9\u4e86\u5168\u740310\u5927\u6d4b\u5e8f\u516c\u53f8\u3002Illumina \u4f4d\u5217\u699c\u9996\uff0c2017\u5e74\u6536\u5165\u8fbe\u523027.52\u4ebf\u7f8e\u5143\u3002\u4e2d\u56fd\u4f01\u4e1a\u83b7\u5f972\u4e2a\u5e2d\u4f4d\uff0c\u5206\u522b\u662f\u534e\u5927\u57fa\u56e0\uff08\u6392\u540d\u7b2c3\uff09\u548c\u91d1\u552f\u667a\uff08\u6392\u540d\u7b2c8\uff09\u3002<\/div>\n
\u00a0<\/div>\n
9.\u8bfa\u534e87\u4ebf\u7f8e\u5143\u6536\u8d2dAveXis\uff0c\u6269\u5927\u57fa\u56e0\u6cbb\u7597\u5e03\u5c40<\/div>\n
4\u67089\u65e5\uff0c\u8bfa\u534e\u5ba3\u5e03\u4ee587\u4ebf\u7f8e\u5143\u6536\u8d2d\u7f8e\u56fd\u57fa\u56e0\u6cbb\u7597\u516c\u53f8 AveXis\uff0c\u4ee5\u6269\u5927\u5176\u5728\u57fa\u56e0\u6cbb\u7597\u548c\u795e\u7ecf\u79d1\u5b66\u65b9\u9762\u7684\u9886\u5bfc\u4f5c\u7528\u3002AveXis \u6b63\u5728\u8fdb\u884c\u810a\u9ad3\u6027\u808c\u840e\u7f29\u75c7\uff08SMA\uff09 \u6cbb\u7597\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u5176\u4ee3\u8868\u6027\u57fa\u56e0\u6cbb\u7597\u5019\u9009\u836f\u7269\u4e3aAVXS-101\u3002<\/div>\n
\u00a0<\/div>\n
10.\u00a0\u7f57\u6c0f\u5b8c\u6210\u5bf9Flatiron Health\u4ef7\u503c19\u4ebf\u7f8e\u5143\u7684\u6536\u8d2d<\/div>\n
\u7f57\u6c0f4\u67087\u65e5\u5ba3\u5e03\uff0c\u5df2\u5b8c\u6210\u6536\u8d2d\u533b\u7597\u6280\u672f\u548c\u670d\u52a1\u516c\u53f8 Flatiron Health\u3002Flatiron Health \u662f\u80bf\u7624\u7535\u5b50\u75c5\u5386\uff08EHR\uff09\u8f6f\u4ef6\u7684\u5e02\u573a\u9886\u5bfc\u8005\u3002\u6b64\u6b21\u4ea4\u6613\u4ef7\u503c\u4e3a19\u4ebf\u7f8e\u5143\uff0c\u5c06\u52a0\u901f\u5b9e\u73b0\u4ee5\u6570\u636e\u4e3a\u5bfc\u5411\u7684\u4e2a\u6027\u5316\u764c\u75c7\u6cbb\u7597\u3002<\/div>\n
\u00a0<\/div>\n
\u00a0<\/div>\n
10.\u817e\u8baf\u4e0eBabylon Health\u5408\u4f5c\uff0cAI\u5065\u5eb7\u8bc4\u4f30\u5c06\u4e0a\u7ebf\u5fae\u4fe1<\/div>\n
4\u67086\u65e5\uff0c\u817e\u8baf\u4e0e\u82f1\u56fd\u6570\u5b57\u533b\u7597\u516c\u53f8 Babylon Health \u8fbe\u6210\u5408\u4f5c\uff0c\u5c06 Babylon Health\u7684AI\u5065\u5eb7\u8bc4\u4f30\u6280\u672f\u5e94\u7528\u4e8e\u817e\u8baf\u7684\u5fae\u4fe1\u793e\u4ea4\u5e73\u53f0\uff0c\u63a8\u52a8 Babylon Health \u8fdb\u5165\u4e2d\u56fd\u5e9e\u5927\u7684\u533b\u7597\u5e02\u573a\u3002<\/div>\n
\u00a0<\/div>\n
11.\u6c83\u5c14\u739b\u6b32\u5c06\u533b\u7597\u670d\u52a1\u5f15\u5165\u8fde\u9501\u8d85\u5e02<\/div>\n
\u8fde\u9501\u5de8\u5934\u6c83\u5c14\u739b\u6b63\u52aa\u529b\u589e\u8fdb\u548c\u533b\u7597\u4fdd\u9669\u516c\u53f8\u54c8\u95e8\u90a3\uff08Humana\uff09\u7684\u5408\u4f5c\u3002\u53cc\u65b9\u6b63\u8bd5\u56fe\u5728\u8fde\u9501\u8d85\u5e02\u5185\u63d0\u4f9b\u57fa\u672c\u7684\u533b\u7597\u670d\u52a1\u3002\u6210\u529f\u5408\u4f5c\u540e\u6c83\u5c14\u739b\u5c06\u83b7\u5f97\u54c8\u95e8\u90a3\u516c\u53f8\u7684\u60a3\u8005\u4fe1\u606f\uff0c\u4e14\u6709\u671b\u5728\u6c83\u5c14\u739b\u8d85\u5e02\u91cc\u589e\u8bbe\u533b\u5e08\u8bca\u6240\uff0c\u7ed9\u6d88\u8d39\u8005\u63d0\u4f9b\u533b\u7597\u670d\u52a1\u3002<\/div>\n
\u00a0<\/div>\n
12.Ferring \u6536\u8d2d\u5fae\u751f\u7269\u7ec4\u5148\u950b Rebiotix<\/div>\n
4\u67086\u65e5\uff0c\u5236\u836f\u516c\u53f8 Ferring \u6536\u8d2d\u5fae\u751f\u7269\u7ec4\u5148\u950b\u516c\u53f8 Rebiotix \u3002\u5c06\u5171\u540c\u81f4\u529b\u4e8e\u7814\u7a76\u4eba\u4f53\u5fae\u751f\u7269\u7ec4\uff0c\u4e3a\u60a3\u8005\u63d0\u4f9b\u5fae\u751f\u7269\u7ec4\u89e3\u51b3\u65b9\u6848\u3002Rebiotix \u62e5\u6709\u9886\u5148\u7684\u5fae\u751f\u7269\u7ec4\u7597\u6cd5\u7814\u7a76\u6210\u679c RBX2660\u3002<\/div>\n
\u76f8\u5173\u94fe\u63a5\uff1a\u6570\u5b57\u5065\u5eb7\u4ea7\u4e1a\u683c\u5c40<\/a>\u00a0\u00a0\u00a0|\u00a0\u00a0\u6bd4\u5c14\u76d6\u83282018 J.P.\u6469\u6839\u5065\u5eb7\u5927\u4f1a\u6f14\u8bb2\uff08\u5168\u6587\uff09\u00a0|\u00a0<\/a>\u00a0\u00a0\u4e2d\u56fd\u751f\u7269\u6280\u672f\u4ea7\u4e1a\u8fdb\u5165\u9ec4\u91d1\u65f6\u4ee3\u00a0 |\u00a0\u00a0<\/a>\u4e03\u4f4d\u521b\u59cb\u4eba\u89e3\u8bfb\u6d88\u8d39\u7ea7\u57fa\u56e0\u5e02\u573a\u00a0<\/a>\u00a0 |\u00a0\u00a0<\/a>\u5e74\u5ea6\u76d8\u70b9-\u4ea7\u4e1a\u7bc7<\/a>\uff08\u80bf\u7624\u8d5b\u9053\uff09\u00a0|\u00a0\u00a0\u00a0\u00a0<\/a>2017\u57fa\u5e74\u5ea6\u76d8\u70b9-\u4ea7\u4e1a\u7bc7\uff08\u5de8\u5934\u8d5b\u9053\uff09<\/a>\u00a0\u00a0\u00a0|\u00a0 \u00a0\u5e74\u5ea6\u76d8\u70b9-\u4ea7\u4e1a\u7bc7<\/a>\uff08\u5fae\u751f\u7269\uff09\u00a0<\/div>\n
\u00a0<\/div>\n
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\"?wx_fmt=png\"\/<\/figure><\/div>\n\n
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1.Cellectis\u52df\u96c61.64\u4ebf\u7f8e\u5143\u63a8\u8fdbCAR-T\u548c\u57fa\u56e0\u7f16\u8f91\u7814\u53d1<\/div>\n
4\u670811\u65e5\uff0c\u57fa\u56e0\u7f16\u8f91\u548c\u514d\u75ab\u7597\u6cd5\u7814\u53d1\u516c\u53f8 Cellectis \u5ba3\u5e03\uff0c\u5728\u516c\u5f00\u52df\u80a1\u4e2d\u5df2\u83b7\u5f97\u7ea61.64\u4ebf\u7f8e\u5143\u8d44\u91d1\uff0c\u5c06\u62e8\u6b3e1\u4ebf\u7f8e\u5143\u7528\u4e8e\u5176\u73b0\u6709\u514d\u75ab\u80bf\u7624\u5019\u9009\u836f\u7269\u7684\u5546\u4e1a\u5316\uff0c\u4e3a\u5019\u9009\u4ea7\u54c1UCART\u63d0\u4f9b2000\u4e07\u7f8e\u5143\uff0c3000\u4e07\u7f8e\u5143\u7528\u4e8e\u7814\u53d1\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u3002<\/div>\n
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2.\u80bf\u7624\u514d\u75ab\u516c\u53f8Constellation\u83b71\u4ebf\u7f8e\u5143\u878d\u8d44<\/div>\n
4\u670810\u65e5\uff0c\u9776\u5411\u548c\u514d\u75ab\u80bf\u7624\u836f\u7269\u7814\u53d1\u516c\u53f8 Constellation \u5ba3\u5e03\u878d\u8d441\u4ebf\u7f8e\u5143\uff0c\u6295\u8d44\u8005\u5305\u62ec Cormorant Asset Management\u3001Deerfield Management \u7b49\u3002\u8fd9\u7b14\u878d\u8d44\u5c06\u7528\u4e8e\u63a8\u8fdb\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5305\u62ec\u5176\u4e3b\u8981\u5019\u9009\u4ea7\u54c1CPI-1205\u548cCPI-0610\u3002<\/div>\n
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3.\u4e01\u9999\u56ed\u5b8c\u6210D\u8f6e\u878d\u8d44\uff0c\u4f30\u503c\u8d8510\u4ebf\u7f8e\u5143<\/div>\n
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4\u67089\u65e5\uff0c\u6570\u95ee\u751f\u7269\u5ba3\u5e03\u5b8c\u6210\u6570\u5343\u4e07\u5143\u4eba\u6c11\u5e01A+\u8f6e\u878d\u8d44\uff0c\u6295\u8d44\u65b9\u4e3a\u6e24\u6ea2\u57fa\u91d1\u3002\u8be5\u57fa\u91d1\u7531\u5929\u58eb\u529b\u63a7\u80a1\u3001\u91cd\u5e86\u5316\u533b\u96c6\u56e2\u3001\u91cd\u5e86\u5e02\u4ea7\u4e1a\u5f15\u5bfc\u57fa\u91d1\u7b49\u673a\u6784\u5171\u540c\u53d1\u8d77\u6210\u7acb\u3002<\/div>\n
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6.\u592a\u7f8e\u533b\u7597\u79d1\u6280\u5b8c\u6210\u4ebf\u5143\u4eba\u6c11\u5e01D\u8f6e\u878d\u8d44<\/div>\n
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\"RmFicvQBAkgApMXDKlzSgkzEbdhWDSA5IbVbkf1eXv8TH1c995PZzDRgAicVhoxsMjebpazbUHcyzf8v4xNbz3FQ\"\/<\/figure><\/div>\n\n<\/div>\n
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1.\u9996\u5c4a\u6570\u5b57\u5065\u5eb7\u79c1\u8463\u4f1a<\/div>\n
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2.2018\uff08\u7b2c\u4e09\u5c4a\uff09\u4eba\u4f53\u5fae\u751f\u7269\u7ec4\u521b\u65b0\u672a\u6765\u8005\u5927\u4f1a<\/div>\n
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\"RmFicvQBAkgCIWN3G58AmstibzqMcoJZEhibvjtIicy1lHl7BQVWsGyLkJvosrOf5ia736uLVNOkKQwJAFcM5zVEbQQ\"\/<\/figure><\/div>\n\n
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