{"id":9688,"date":"2018-10-29T14:27:17","date_gmt":"2018-10-29T06:27:17","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&mid=100005561&idx=1&sn=53644fea4f530d22f522d87fde930828&chksm=6b72a40e5c052d18f5b5ab17825b69e9f159bec074f2d784250a05294ac0cf4b4acfb5c16533#rd"},"modified":"2026-04-08T10:35:52","modified_gmt":"2026-04-08T02:35:52","slug":"102101102-2","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2018\/10\/29\/102101102-2\/","title":{"rendered":"\u72ec\u5bb6\u4e13\u8bbf\u4e2d\u56fd\u5b66\u8005\u300aNature\u300b\u5b50\u520a\u53d1\u5e03\u6700\u5927\u89c4\u6a21\u80ba\u764cT\u7ec6\u80de\u5355\u7ec6\u80de\u514d\u75ab\u56fe\u8c31"},"content":{"rendered":"

<\/p>\n

\n\n
\n
\"RmFicvQBAkgCuC54K47siaoibvbClYbpoQdmoEA7Yo9T0l4l5c9wsK8DWv13zXvBYojNDUX4HpbxOEe8enSicCuVVg\"\/<\/figure><\/div>\n\n<\/div>\n
<\/div>\n
<\/div>\n
\u5173\u952e\u8bcd\uff1a\u80ba\u764c \u5355\u7ec6\u80de\u6d4b\u5e8f\u00a0\u00a0T\u7ec6\u80de<\/div>\n
\u9605\u8bfb\u65f6\u95f4\uff1a\u7ea67\u5206\u949f<\/div>\n
<\/div>\n
<\/div>\n
\u6587\/\u57fa\u56e0\u6167<\/div>\n
<\/div>\n
2018\u5e746\u670826\u65e5\u51cc\u66681:00\uff0c\u300aNature Medicine\u300b\u53d1\u8868\u8fc4\u4eca\u9488\u5bf9\u80bf\u7624\u76f8\u5173T\u7ec6\u80de\u7684\u89c4\u6a21\u6700\u5927\u7684\u5355\u7ec6\u80de\u7ec4\u5b66\u7814\u7a76\uff0c\u5317\u5927\u5f20\u6cfd\u6c11\u6559\u6388\u56e2\u961f\u901a\u8fc7\u975e\u5c0f\u7ec6\u80de\u80ba\u764c12,346\u4e2aT\u7ec6\u80de\u7684\u5355\u7ec6\u80de\u6d4b\u5e8f\u53ca\u5206\u6790\uff0c\u53d1\u73b0\u4e86\u53ef\u80fd\u7684\u80ba\u764c\u65b0\u9776\u70b9\u3002\u57fa\u56e0\u6167\u5bf9\u5f20\u6cfd\u6c11\u6559\u6388\u53ca\u8be5\u7814\u7a76\u4e3b\u8981\u53c2\u4e0e\u8005\u8fdb\u884c\u4e86\u72ec\u5bb6\u6df1\u5ea6\u91c7\u8bbf\u3002\u6b22\u8fce\u7559\u8a00\u53c2\u4e0e\u8ba8\u8bba\u3002<\/div>\n
<\/div>\n
<\/div>\n
<\/div>\n
\n\n
\n
\"?wx_fmt=jpeg\"\/<\/figure><\/div>\n\n
\u56fe1\uff1a \u00a0\u80bf\u7624\u514d\u75ab\u7ec6\u80de\u5355\u7ec6\u80de\u6d4b\u5e8f\u6d41\u7a0b\u56fe\uff0c\u56fe\u7247\u6765\u81ea\u300aNature Medicine\u300b<\/div>\n
1\u3001\u7814\u7a76\u80cc\u666f<\/div>\n
\u00b7 \u514d\u75ab\u6cbb\u7597\u764c\u75c7\u7684\u6548\u679c\u5224\u65ad\u7f3a\u4e4f\u4f9d\u636e<\/div>\n
\u00b7\u00a0\u80bf\u7624\u7684\u514d\u75ab\u9003\u9038\u673a\u5236\u4f7fT\u7ec6\u80de\u53d7\u5230\u6291\u5236<\/div>\n
\u00b7 \u5317\u5927\u5f20\u6cfd\u6c11\u56e2\u961f\u7684\u764c\u75c7\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\u6280\u672f<\/div>\n
\u5f53\u524d\u514d\u75ab\u6cbb\u7597\u5df2\u7ecf\u6210\u4e3a\u6cbb\u7597\u591a\u79cd\u764c\u75c7\u7684\u6709\u6548\u7b56\u7565\u800c\u53d7\u5230\u5e7f\u6cdb\u5173\u6ce8\u3002\u4f46\u5bf9\u6cbb\u7597\u6548\u679c\u7684\u5224\u65ad\u8fd8\u76f8\u5f53\u7f3a\u4e4f\u4f9d\u636e\uff0c\u6bd4\u5982\u63a5\u6536\u540c\u6837\u836f\u7269\u6cbb\u7597\u7684\u540c\u4e00\u7c7b\u764c\u79cd\u7684\u60a3\u8005\uff0c\u4e3a\u4ec0\u4e48\u6548\u679c\u76f8\u8ddd\u751a\u8fdc\uff1f\u8fd9\u610f\u5473\u7740\u80bf\u7624\u514d\u75ab\u8fc7\u7a0b\u4e2d\u7684\u4e00\u4e9b\u57fa\u7840\u6027\u95ee\u9898\u8fd8\u6709\u5f85\u89e3\u7b54\u3002<\/div>\n
\u00a0<\/div>\n
T\u6dcb\u5df4\u7ec6\u80de\u662f\u6d88\u706d\u764c\u7ec6\u80de\u7684\u6838\u5fc3\u514d\u75ab\u7ec6\u80de\u7c7b\u578b\uff0c\u4f46\u662f\u7531\u4e8e\u80bf\u7624\u5177\u6709\u591a\u79cd\u514d\u75ab\u9003\u9038\u673a\u5236\uff0c\u5373\u4f7f\u662f\u6d78\u6da6\u5728\u80bf\u7624\u7ec4\u7ec7\u5185\u90e8\u7684T\u7ec6\u80de\u4e5f\u53d7\u5230\u5e7f\u6cdb\u7684\u6291\u5236\u3002\u9762\u5bf9\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u4e0d\u540c\u7c7b\u578b\u7684\u514d\u75ab\u7ec6\u80de\uff0c\u5355\u7ec6\u80de\u6c34\u5e73\u7684\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u548c\u751f\u7269\u4fe1\u606f\u5b66\u5206\u6790\u624b\u6bb5\u5927\u6709\u7528\u6b66\u4e4b\u5730\u3002<\/div>\n
\u5317\u4eac\u5927\u5b66\u5f20\u6cfd\u6c11\u5b9e\u9a8c\u5ba4\u5c06\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\u6280\u672f\u5e94\u7528\u4e8e\u80bf\u7624\u7814\u7a76\u5df2\u7ecf\u5728\u56fd\u9645\u4e0a\u5360\u6709\u4e00\u5e2d\u4e4b\u5730\u30022017\u5e746\u670815\u65e5\uff0c\u5f20\u6cfd\u6c11\u56e2\u961f\u5728\u300aCell\u300b\u53d1\u6587\uff0c\u9996\u6b21\u523b\u753b\u4e86\u809d\u764cT\u7ec6\u80de\u7684\u514d\u75ab\u56fe\u8c31\uff08\u57fa\u56e0\u6167\u72ec\u5bb6\u4e13\u8bbf<\/a>\uff09\u3002\u65f6\u9694\u4e00\u5e74\uff0c\u4ed6\u4eec\u5728\u300aNature Medicine\u300b\u53d1\u8868\u9898\u4e3a\u201cGlobal characterization of T cells in non-small-cell lung cancer by single-cell sequencing\u201d\u7684\u7814\u7a76\u8bba\u6587\uff0c\u5e26\u6765\u4e86\u80ba\u764c\u7684\u7814\u7a76\u6210\u679c\u3002\u57fa\u56e0\u6167\u72ec\u5bb6\u91c7\u8bbf\u62a5\u9053\u5185\u5bb9\u5982\u4e0b\u3002<\/div>\n
\u00a0<\/div>\n
2\u3001\u7814\u7a76\u6210\u679c<\/div>\n
\u00b7 T\u7ec6\u80de\u4e9a\u7fa4\u514d\u75ab\u7279\u5f81<\/div>\n
\u00b7 \u8017\u7aed\u524dT\u7ec6\u80de\u4e0e\u8017\u7aed\u6027T\u7ec6\u80de\u6d78\u6da6\u6bd4\u4f8b\u4e0e\u9884\u540e\u76f8\u5173<\/div>\n
\u00b7 \u6fc0\u6d3b\u6001Treg\u7684\u6bd4\u4f8b\u4e0e\u80ba\u817a\u764c\u75c5\u4eba\u7684\u9884\u540e\u76f8\u5173<\/div>\n
\u00b7 \u65b0\u751f\u7269\u6807\u5fd7\u7269<\/div>\n
\u3010\u57fa\u56e0\u6167\u3011\u5f20\u6559\u6388\uff0c\u7ee7\u53bb\u5e746\u6708\u60a8\u5728\u300aCell\u300b\u6742\u5fd7\u53d1\u8868\u809d\u764c T\u7ec6\u80de\u56fe\u8c31\u7814\u7a76\uff08\u8be6\u60c5<\/a>\uff09\uff0c\u65f6\u9694\u4e00\u5e74\uff0c \u60a8\u5e26\u9886\u56e2\u961f\u5b8c\u6210\u4e86\u975e\u5c0f\u7ec6\u80de\u80ba\u764c12,346\u4e2aT\u7ec6\u80de\u7684\u5355\u7ec6\u80de\u6d4b\u5e8f\u5de5\u4f5c\uff0c \u53d1\u8868\u5728 \u300aNature Medicine\u300b\u4e0a\uff0c\u636e\u8bf4\u662f\u56fd\u9645\u4e0a\u80bf\u7624\u76f8\u5173T\u7ec6\u80de\u7684\u89c4\u6a21\u6700\u5927\u7684\u5355\u7ec6\u80de\u7ec4\u5b66\u7814\u7a76\uff0c\u60a8\u80fd\u901a\u4fd7\u5730\u5411\u57fa\u56e0\u6167\u8bfb\u8005\u8c08\u8c08\u8fd9\u9879\u6210\u679c\u7684\u53d1\u73b0\u548c\u610f\u4e49\u5417\uff1f<\/div>\n
\u3010\u5f20\u6cfd\u6c11\u6559\u6388\u3011\u90ed\u5fc3\u6021\u535a\u58eb\u662f\u672c\u7814\u7a76\u6838\u5fc3\u4eba\u7269\uff0c\u7b2c\u4e00\u4f4d\u7684\u5171\u540c\u4e00\u4f5c\uff0c\u53ef\u4ee5\u4e3a\u8bfb\u8005\u89e3\u7b54\u8fd9\u4e2a\u95ee\u9898\u3002<\/div>\n
\u3010\u90ed\u5fc3\u6021\u535a\u58eb\u3011\u8be5\u9879\u7814\u7a76\u5b8c\u6210\u4e86\u6765\u81ea14\u4f8b\u975e\u5c0f\u7ec6\u80de\u764c\u521d\u6cbb\u60a3\u8005\u5916\u5468\u8840\u3001\u764c\u7ec4\u7ec7\u53ca\u764c\u65c1\u7ec4\u7ec7\u768412,346\u4e2aT\u7ec6\u80de\u7684\u5355\u7ec6\u80de\u6d4b\u5e8f\u5de5\u4f5c\u3002\u57fa\u4e8eT\u7ec6\u80de\u7684\u8f6c\u5f55\u7ec4\u6570\u636e\u53caT\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u5e8f\u5217\uff0c\u6211\u4eec\u4ece\u5355\u7ec6\u80de\u5c42\u9762\u89c2\u5bdf\u5230CD8+ T\u7ec6\u80de\u7fa4\u4f53\u5b58\u5728\u5927\u91cf\u514b\u9686\u6269\u589e\uff0c\u8fdb\u800c\u523b\u753b\u4e86T\u7ec6\u80de\u529f\u80fd\u4e9a\u7fa4\u3001\u5404\u4e9a\u7fa4\u7684\u7ec4\u7ec7\u5206\u5e03\u7279\u5f81\u53ca\u4e9a\u7fa4\u95f4\u7684\u72b6\u6001\u8f6c\u6362\u5173\u7cfb\u7b49\u514d\u75ab\u7279\u5f81\uff0c\u8fd9\u5305\u62ec\u4e00\u4e2a\u8017\u7aed\u6027T\u7ec6\u80de\u4e9a\u7fa4\u548c\u4e24\u4e2a\u8017\u7aed\u524dT\u7ec6\u80de\u4e9a\u7fa4\uff0c\u8017\u7aed\u524dT\u7ec6\u80de\u4e0e\u8017\u7aed\u6027T\u7ec6\u80de\u7684\u6d78\u6da6\u6bd4\u4f8b\u4e0e\u80ba\u817a\u764c\u60a3\u8005\u9884\u540e\u76f8\u5173\u3002<\/div>\n
\u00a0<\/div>\n
\u5728CD4+T\u7ec6\u80de\u4e2d\u53d1\u73b0\u80bf\u7624\u6d78\u6da6\u7684Treg\u4e2d\u5b58\u5728\u7684\u5f02\u8d28\u6027\uff0c\u6839\u636e TNFRSF9\u7684\u8868\u8fbe\u53ef\u4ee5\u5c06\u5176\u5206\u4e3a\u6d3b\u6027\u9ad8\u4f4e\u7684\u4e24\u7fa4\uff0c\u5176\u4e2d\u6fc0\u6d3b\u6001Treg\u7684\u6bd4\u4f8b\u4e0e\u80ba\u817a\u764c\u75c5\u4eba\u7684\u9884\u540e\u76f8\u5173\u3002\u8fd9\u4e9b\u751f\u7269\u6807\u5fd7\u7269\u7684\u53d1\u73b0\u5bf9\u80ba\u764c\u75c5\u4eba\u7684\u4e34\u5e8a\u5206\u578b\u5177\u6709\u91cd\u8981\u6307\u5bfc\u610f\u4e49\uff0c\u4e5f\u4e3a\u80ba\u764c\u7cbe\u51c6\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u7684\u601d\u8def\u3002<\/div>\n\n
\n
\"RmFicvQBAkgCmh7XECNpZXsjgWjlVyU7nia5UJzMbB87tLiaLmy9pJAHpsoU6cP4icBKQYkeQYibia7tR0WffzhV0QHg\"\/<\/figure><\/div>\n\n
\u56fe2\uff1a\u5f20\u6559\u6388\u56e2\u961f\u7167\u7247\uff0c\u7167\u7247\u7531\u5b9e\u9a8c\u5ba4\u56e2\u961f\u63d0\u4f9b<\/div>\n
3\u3001\u6280\u672f\u8def\u7ebf\u7684\u521b\u65b0\u4e0e\u7a81\u7834<\/div>\n
\u00b7 \u80ba\u764cT\u7ec6\u80de\u6709\u4e09\u4e2a\u4e9a\u7fa4<\/div>\n
\u00b7 \u8f85\u52a9T\u7ec6\u80de\u548c\u8c03\u8282T\u7ec6\u80de<\/div>\n
\u3010\u57fa\u56e0\u6167\u3011\u6b64\u524d\uff0c\u300aNature Immunology\u300b\u62a5\u9053\u80ba\u764c\u6d78\u6da6 CD8 T \u7ec6\u80de\u7684\u7ec4\u7ec7\u539f\u4f4d\u8bb0\u5fc6\u7279\u5f81\uff0c\u662f\u5c06 CD8 \u7ec6\u80de\u4f5c\u4e3a\u4e00\u4e2a\u7fa4\u4f53\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u800c\u672c\u6b21\u53d1\u73b0\u80ba\u764c T\u7ec6\u80de\u6709\u4e09\u4e2a\u4e9a\u7fa4\uff0c\u80fd\u8c08\u8c08\u5176\u4e2d\u7684\u65b9\u6cd5\u521b\u65b0\u548c\u7a81\u7834\u5417?\u7279\u522b\u662f\u5728\u6280\u672f\u8def\u7ebf\u4e0a\u3002<\/div>\n
\u3010\u90d1\u826f\u6d9b\u3011\uff08\u8d1f\u8d23\u751f\u7269\u4fe1\u606f\u5206\u6790\u3001\u672c\u7814\u7a76\u5171\u540c\u4e00\u4f5c\uff09Anusha Preethi Ganesan \u7b492017\u5e74\u53d1\u8868\u5728\u300aNature Immunology\u300b\u7684\u5de5\u4f5c\u5f88\u4e0d\u9519\uff0c\u5229\u7528RNAseq\u3001\u6d41\u5f0f\u7ec6\u80de\u672f\u7b49\u6280\u672f\u5bf9\u80ba\u764c\u7684CD8+ T\u7ec6\u80de\u7684\u5206\u5b50\u7279\u5f81\u4f5c\u4e86\u521d\u6b65\u7684\u5206\u6790\u3002<\/div>\n
\u00a0<\/div>\n
\u4e0e\u4e4b\u76f8\u6bd4\uff0c\u6211\u4eec\u7684\u7814\u7a76\u4e3b\u8981\u662f\u5229\u7528\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\u6280\u672f\uff0c\u5f97\u5230\u4e86\u8d28\u91cf\u66f4\u597d\u7684\u3001\u5355\u4e2a\u7ec6\u80de\u7ea7\u522b\u8fd9\u6837\u9ad8\u5206\u8fa8\u7387\u7684\u6570\u636e\u3002\u76f8\u5e94\u7684\uff0c\u6211\u4eec\u7684\u6570\u636e\u4e5f\u7ed9\u6211\u4eec\u5e26\u6765\u4e86\u5bf9\u80ba\u764cT\u7ec6\u80de\u514d\u75ab\u66f4\u6df1\u5165\u7684\u4e86\u89e3\u3002Anusha Preethi\u7b49\u7684\u5de5\u4f5c\u53ef\u4ee5\u770b\u5230TIL\u4f5c\u4e3a\u4e00\u4e2a\u7fa4\u4f53\uff0c\u5176TCR\u901a\u8def\u548c\u514d\u75ab\u68c0\u9a8c\u70b9\u76f8\u5173\u57fa\u56e0\u7684\u8868\u8fbe\u5728\u80ba\u764c\u75c5\u4eba\u95f4\u7684\u5f02\u8d28\u6027\uff0c\u800c\u6211\u4eec\u7684\u6570\u636e\u8fd8\u53ef\u4ee5\u770b\u5230\u540c\u6837\u4e00\u4e2a\u75c5\u4eba\u7684TIL\u5185\u90e8\u4e0d\u540c\u7684\u5355\u7ec6\u80de\u7684\u5f02\u8d28\u6027\u3002<\/div>\n
\u00a0<\/div>\n
\u5728Anusha Preethi\u7684\u7814\u7a76\u91cc\uff0c\u4f5c\u8005\u4eceRNAseq\u6570\u636e\u91cc\u63d0\u524d\u51fa\u6765TCR beta\u7684\u5e8f\u5217\u3001\u8ba1\u7b97\u514b\u9686\u6307\u6570\u3002\u800c\u6211\u4eec\u7684\u7814\u7a76\u91cc\u5728\u540c\u4e00\u4e2a\u7ec6\u80de\u4e2d\u5f97\u5230\u8f6c\u5f55\u7ec4\u4fe1\u606f\u7684\u540c\u65f6\uff0c\u7ec4\u88c5\u51fa\u4e86\u5168\u957f\u7684TCR\u5e8f\u5217\uff0c\u5305\u62ecalpha\u94fe\u548cbeta\u94fe\uff1b\u4e0d\u4ec5\u4f5c\u4e86TCR\u514b\u9686\u6269\u589e\u5206\u6790\uff0c\u8fd8\u6839\u636e\u6bcf\u4e2a\u7ec6\u80de\u7684TCR\u5e8f\u5217\u8ffd\u8e2aT\u7ec6\u80de\u7684\u72b6\u6001\u8f6c\u6362\u3002\u5b8c\u6574\u7684\u8f6c\u5f55\u7ec4\u4fe1\u606f\u3001TCR\u4fe1\u606f\u7ed9\u6211\u4eec\u6d4b\u8bd5\u3001\u7b5b\u9009\u80bf\u7624\u6297\u539f\u7279\u5f02\u7684TCR\u5e8f\u5217\u63d0\u4f9b\u4e86\u72ec\u7279\u7684\u673a\u4f1a\u3002<\/div>\n
\u00a0<\/div>\n
Anusha Preethi\u7684\u5206\u6790\u8ba4\u4e3a\u663e\u793a\u4e86\u7ec4\u7ec7\u9a7b\u7559\u8bb0\u5fc6T\u7ec6\u80de\uff08TRM\uff09\u7279\u5f81\u7684TIL\u4e0eT\u7ec6\u80de\u6bd2\u6027\u53cd\u5e94\u7684\u5f3a\u5ea6\u6709\u5173\uff0c\u5e76\u4e14\u66f4\u9ad8\u5bc6\u5ea6\u7684TRM\u9884\u793a\u7740\u80ba\u764c\u75c5\u4eba\u66f4\u597d\u7684\u751f\u5b58\u7ed3\u679c\u3002\u5b9e\u9645\u4e0a\uff0cAnusha Preethi\u7684\u6570\u636e\u91cc\uff0cTRM\u7279\u5f81\u662f\u548cT\u7ec6\u80de\u8017\u7aed\u7a0b\u5e8f\u5076\u8054\u5728\u4e00\u8d77\u7684\uff0c\u5373\u9ad8\u8868\u8fbe\u4e86TRM\u7684TIL\u7fa4\u4f53\u4e5f\u9ad8\u8868\u8fbe\u4e86PDCD1\u30014-1BB\u3001HAVCR2\u7b49\u6291\u5236T\u7ec6\u80de\u529f\u80fd\u7684\u57fa\u56e0\u3002\u4ece\u6211\u4eec\u7684\u6570\u636e\u53d1\u73b0\uff0cTIL\u53ef\u4ee5\u5206\u4e3a\u4e09\u4e2a\u4e3b\u8981\u4e9a\u7fa4\uff0c\u5176\u4e2d\u5305\u62ec\u4e00\u7fa4\u663e\u793a\u4e86\u8017\u7aed\u72b6\u6001\u76f8\u5173\u57fa\u56e0\u7684\u9ad8\u5ea6\u8868\u8fbe\uff0c\u540c\u65f6\u4e5f\u663e\u793a\u4e86TRM\u7279\u5f81\uff0c\u6211\u4eec\u5b9a\u4e49\u4e3a\u201c\u8017\u7aed\u7ec6\u80de\u201d\uff08Tex\uff09\uff1b\u53e6\u4e00\u7fa4\u540c\u6837\u4e5f\u663e\u793a\u4e86TRM\u7684\u7279\u5f81\uff0c\u4f46\u6ca1\u6709\u663e\u793a\u8017\u7aed\u7684\u72b6\u6001\uff0c\u8fd9\u7fa4\u7ec6\u80de\u6709Hobit(ZNF683)\u7684\u7279\u5f02\u9ad8\u8868\u8fbe\uff08Hobit-hi TRM\uff09\u3002Hobit\u662f\u53e6\u4e00\u4e2aTRM\u7684\u7279\u5f81\u57fa\u56e0\uff0c\u800c\u5728Anusha Preethi\u7684\u7814\u7a76\u4e2d\u5e76\u672a\u63d0\u53ca\u3002\u6211\u4eec\u7684\u5206\u6790\u663e\u793a\uff0cHobit-hi TRM \u76f8\u5bf9\u4e8eTex\u7684\u6bd4\u4f8b\uff0c\u53ef\u4ee5\u4f5c\u4e3a\u9884\u540e\u7684\u6307\u6807\uff0cTIL\u4e2d\u6709\u66f4\u9ad8\u6bd4\u4f8b\u7684Hobit-hi TRM \u7684\u80ba\u764c\u60a3\u8005\u6709\u66f4\u597d\u7684\u751f\u5b58\u3002\u8017\u7aed\u7ec6\u80de\u5bf9\u80bf\u7624\u514d\u75ab\u7684\u4f5c\u7528\u76ee\u524d\u8fd8\u672a\u5f7b\u5e95\u5f04\u6e05\u695a\uff0c\u66f4\u7cbe\u786e\u7684\u533a\u5206\u51faTIL\u7684\u4e0d\u540c\u529f\u80fd\u72b6\u6001\u5bf9\u540e\u7eed\u7814\u7a76\u6709\u6307\u5bfc\u610f\u4e49\u3002\u56e0\u6b64\u6211\u4eec\u7684\u7814\u7a76\u5b9e\u9645\u4e0a\u6bd4Anusha Preethi\u53c8\u8de8\u51fa\u4e86\u4e00\u6b65\u3002<\/div>\n
\u00a0<\/div>\n
\u3010\u5f20\u56ed\u56ed\u3011\uff08\u8d1f\u8d23\u751f\u7269\u4fe1\u606f\u5206\u6790\u3001\u672c\u7814\u7a76\u5171\u540c\u4e00\u4f5c\uff09\u6211\u4eec\u8fd8\u523b\u753b\u4e86CD4+\u6548\u5e94T\u7ec6\u80de\u3001CD8+\u6548\u5e94T\u7ec6\u80de\u7684\u7279\u5f81\uff0c\u53d1\u73b0\u8fd9\u4e24\u7fa4\u6548\u5e94T\u7ec6\u80de\u5728\u80ba\u764c\u60a3\u8005\u91cc\u6709\u8f83\u9ad8\u7684\u514b\u9686\u6269\u589e\u3001\u5e76\u4e14\u5177\u6709\u8f83\u9ad8\u7684\u7ec6\u80de\u8fc1\u79fb\u901a\u8def\u7684\u6d3b\u6027\u3002\u4ece\u7ec4\u7ec7\u5206\u5e03\u89d2\u5ea6\u5206\u6790\uff0c\u6211\u4eec\u53d1\u73b0\u8fd9\u4e24\u7fa4\u7ec6\u80de\u5728\u5916\u5468\u8840\u3001\u764c\u65c1\u7ec4\u7ec7\u3001\u7ec4\u7ec7\u91cc\u90fd\u6709\u5206\u5e03\u3002\u6b64\u5916\uff0cAnusha Preethi\u7684\u7814\u7a76\u53ea\u5c40\u9650\u4e8eCD8+ TIL\uff0c\u6211\u4eec\u7684\u7814\u7a76\u540c\u65f6\u505a\u4e86\u8f85\u52a9T\u7ec6\u80de\u3001\u8c03\u8282T\u7ec6\u80de\u7684\u5206\u6790\uff0c\u53d1\u73b0Treg\u4e2d\u5177\u6709\u9884\u540e\u610f\u4e49\u7684\u7279\u5f81\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u7684\u7814\u7a76\u66f4\u5168\u9762\u3001\u66f4\u7ec6\u81f4\u3002<\/div>\n\n
\n
\"RmFicvQBAkgAYWnUOibUl98l0jicGfR6ficglwROwnPh8MAoDiaDZ6KfuRicoHMXxnwTyEW2hAoW3Bibbrakict7h73CYQ\"\/<\/figure><\/div>\n\n
\u56fe3\uff1a\u5f20\u6559\u6388\u56e2\u961f\u548c\u5317\u533b\u4e09\u9662\u56e2\u961f\u5408\u5f71\uff0c\u7167\u7247\u7531\u5b9e\u9a8c\u5ba4\u56e2\u961f\u63d0\u4f9b<\/div>\n
4\u3001\u809d\u764c\u4e0e\u80ba\u764c\u7814\u7a76\u7684\u5f02\u540c<\/div>\n
\u00b7 \u514d\u75ab\u6cbb\u7597\u5bf9\u80ba\u764c\u6709\u66f4\u9ad8\u7684\u54cd\u5e94\u7387<\/div>\n
\u00b7 \u80ba\u764c\u548c\u809d\u764c\u4e2d\u90fd\u5b58\u5728\u8017\u7aedT\u7ec6\u80de<\/div>\n
\u00b7 PanCancer \u7814\u7a76\u53d6\u5f97\u521d\u6b65\u7ed3\u679c<\/div>\n
\u3010\u57fa\u56e0\u6167\u3011\u60a8\u66fe\u4e8e\u53bb\u5e74 6\u6708\u5728\u300aCell \u300b\u53d1\u8868\u5927\u89c4\u6a21\u809d\u764c T\u7ec6\u80de\u56fe\u8c31\u7814\u7a76\u3002\u809d\u764c\u548c\u80ba\u764c\uff0c\u8fd9\u4e24\u79cd\u91cd\u5927\u764c\u75c7\u514d\u75ab\u53cd\u5e94\u6709\u4ec0\u4e48\u5f02\u540c\u5462\uff1f\u4e0d\u540c\u764c\u75c7\u7684T\u7ec6\u80de\u7814\u7a76\u662f\u5426\u53ef\u4ee5\u76f8\u4e92\u501f\u9274\uff1f\u63a5\u4e0b\u6765\u60a8\u662f\u5426\u6709\u8003\u8651 Pan-Cancer \uff08\u6cdb\u764c\u75c7\uff09 \u7684\u7814\u7a76\u6216\u8005\u7ee7\u7eed\u9488\u5bf9\u4e0b\u4e00\u4e2a\u764c\u79cd\uff1f<\/div>\n
\u3010\u5f20\u6cfd\u6c11\u6559\u6388\u3011\u4e34\u5e8a\u4e0a\uff0c\u76ee\u524d\u6765\u770b\u514d\u75ab\u6cbb\u7597\u5bf9\u80ba\u764c\u6709\u66f4\u9ad8\u7684\u54cd\u5e94\u7387\uff0c\u800c\u5b9e\u9645\u4e0a\u809d\u764c\u4e5f\u662f\u6709\u8f83\u591aT\u7ec6\u80de\u6d78\u6da6\u7684\u3002\u4ece\u6211\u4eec\u7684\u809d\u764cT\u7ec6\u80de\u7814\u7a76\u548c\u80ba\u764cT\u7ec6\u80de\u7814\u7a76\u4e2d\u53ef\u4ee5\u770b\u5230\u809d\u764c\u60a3\u8005\u7684T\u7ec6\u80de\u548c\u80ba\u764c\u60a3\u8005\u7684T\u7ec6\u80de\u7684\u76f8\u4f3c\u7684\u5730\u65b9\uff0c\u4e5f\u53ef\u4ee5\u770b\u5230\u4e24\u8005\u4e0d\u4e00\u6837\u7684\u5730\u65b9\u3002<\/div>\n
\u00a0<\/div>\n
\u5bf9\u4e8eCD8+ TIL\uff0c\u5728\u4e24\u4e2a\u764c\u79cd\u91cc\u6211\u4eec\u90fd\u770b\u5230\u4e86\u8017\u7aedT\u7ec6\u80de\u7684\u5b58\u5728\uff0c\u5e76\u4e14\u5b83\u4eec\u663e\u793a\u4e86\u975e\u5e38\u76f8\u4f3c\u7684\u57fa\u56e0\u8868\u8fbe\u7279\u5f81\uff1b\u4e24\u4e2a\u764c\u79cd\u91cc\u4e5f\u90fd\u6709\u4e00\u7fa4\u9ad8\u8868\u8fbeGZMK\u7684\u672a\u8017\u7aedT\u7ec6\u80de\u3002\u7136\u800c\uff0c\u809d\u764c\u91cc\u6709\u66f4\u591a\u7684MAIT\u7ec6\u80de\uff0c\u8fd9\u53ef\u80fd\u548c\u809d\u7ec4\u7ec7\u7684\u514d\u75ab\u7279\u70b9\u6709\u5173\u7cfb\uff1b\u80ba\u7ec4\u7ec7\u91cc\u6709\u66f4\u591a\u7684\u6548\u5e94T\u7ec6\u80de\uff0c\u7279\u522b\u662f\uff0c\u80ba\u764c\u91cc\u6709\u660e\u663e\u66f4\u591a\u7684Hobit-hi TRM\u3002\u8fd9\u4e9b\u7279\u70b9\u53ef\u80fd\u548c\u80ba\u764c\u66f4\u597d\u7684\u514d\u75ab\u6cbb\u7597\u6548\u679c\u6709\u5173\u3002<\/div>\n
\u6211\u4eec\u4f7f\u7528\u4e86\u7c7b\u4f3c\u7684\u6280\u672f\u5bf9\u4e0d\u540c\u7684\u764c\u75c7\u8fdb\u884c\u5206\u6790\uff0c\u5728\u5355\u7ec6\u80de\u6280\u672f\u3001\u6570\u636e\u5206\u6790\u65b9\u6cd5\u7b49\u65b9\u9762\u53ef\u4ee5\u76f8\u4e92\u501f\u9274\u3002\u6211\u4eec\u8ba4\u4e3a\uff0c\u6211\u4eec\u73b0\u5728\u5206\u6790\u7684\u764c\u75c7\u4ee5\u53ca\u6837\u672c\u91cf\uff0c\u8fd8\u4e0d\u80fd\u8986\u76d6\u6240\u6709\u7684\u764c\u75c7\u548c\u60a3\u8005\u7684\u60c5\u51b5\u3002\u56e0\u6b64\u6211\u4eec\u8fd8\u4f1a\u7ee7\u7eed\u5206\u6790\u5176\u5b83\u764c\u79cd\u3002\u6211\u4eec\u5df2\u7ecf\u6b63\u5728\u7528\u5305\u62ecSMART-seq2\u548c10X\u5728\u5185\u7684\u5355\u7ec6\u80de\u6280\u672f\uff0c\u5206\u6790\u591a\u4e2a\u764c\u79cd\u7684\u80bf\u7624\u5fae\u73af\u5883\uff0c\u4e0d\u4ec5\u5305\u62ecT\u7ec6\u80de\uff0c\u8fd8\u5305\u62ec\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\u3001\u5176\u4ed6\u975e\u514d\u75ab\u7ec6\u80de\u4ee5\u53ca\u80bf\u7624\u7ec6\u80de\uff1b\u6211\u4eec\u4e5f\u5728\u5f00\u5c55\u5bf9\u514d\u75ab\u7ec6\u80de\u7684\u8868\u89c2\u8c03\u63a7\u5206\u6790\u3002<\/div>\n
\u3010\u90d1\u826f\u6d9b\u3011\u6211\u4eec\u5df2\u7ecf\u5728\u8fdb\u884c Pan-Cancer \u7684\u7814\u7a76\uff0c\u4e5f\u6709\u4e86\u4e00\u4e9b\u521d\u6b65\u7ed3\u679c\uff0c\u5e0c\u671b\u4e0d\u4e45\u7684\u5c06\u6765\u53ef\u4ee5\u548c\u5927\u5bb6\u5206\u4eab\u3002<\/div>\n
\u00a0<\/div>\n
5\u3001\u4ea7\u3001\u5b66\u3001\u7814\u3001\u533b\u5408\u4f5c\u6a21\u5f0f<\/div>\n
\u00b7 \u5b66\u6821\u3001\u533b\u9662\u3001\u836f\u5382\u534f\u540c<\/div>\n
\u00b7 \u63a2\u7d22\u4e34\u5e8a\u9700\u6c42<\/div>\n
\u00b7 \u9ad8\u8d28\u91cf\u6570\u636e\u5f15\u5bfc\u751f\u7269\u5b66\u53d1\u73b0<\/div>\n
\u3010\u57fa\u56e0\u6167\u3011\u6211\u4eec\u770b\u5230\uff0c\u8fd9\u9879\u91cd\u5927\u7814\u7a76\u6210\u679c\u662f\u5317\u5927\u751f\u79d1\u9662\u3001\u5317\u4eac\u672a\u6765\u57fa\u56e0\u8bca\u65ad\u9ad8\u7cbe\u5c16\u521b\u65b0\u4e2d\u5fc3\u3001\u5317\u5927-\u6e05\u534e\u751f\u547d\u79d1\u5b66\u8054\u5408\u4e2d\u5fc3\u3001\u5317\u533b\u4e09\u9662\u80f8\u5916\u79d1\u4ee5\u53ca\u62dc\u8033\u5236\u836f\u516c\u53f8\u7684\u80bf\u7624\u90e8\u95e8\u5171\u540c\u8054\u5408\u5b8c\u6210\uff0c\u5bf9\u4e8e\u8fd9\u6837\u7684\u4ea7\u3001\u5b66\u3001\u7814\u3001\u533b\u5408\u4f5c\u6a21\u5f0f\uff0c\u60a8\u89c9\u5f97\u6709\u54ea\u4e9b\u503c\u5f97\u63a8\u5e7f\u7684\u5730\u65b9\u3002<\/div>\n
\u3010\u5f20\u6cfd\u6c11\u6559\u6388\u3011\u6211\u4eec\u5b9e\u9a8c\u5ba4\u505a\u79d1\u7814\u7684\u7406\u5ff5\u662f\u7528\u6700\u5c16\u7aef\u7684\u6280\u672f\u3001\u6700\u624e\u5b9e\u7684\u79d1\u5b66\u6765\u653b\u514b\u80bf\u7624\u6cbb\u7597\u548c\u5236\u836f\u4e2d\u6700\u4e9f\u5f85\u89e3\u51b3\u7684\u95ee\u9898\u3002\u6240\u4ee5\u6211\u4eec\u4e00\u65b9\u9762\u8ddf\u533b\u9662\u5408\u4f5c\uff0c\u63a2\u7d22\u4e34\u5e8a\u9700\u6c42\uff0c\u53e6\u4e00\u65b9\u9762\u6211\u4eec\u548c\u836f\u7269\u5f00\u53d1\u56e2\u961f\u5408\u4f5c\uff0c\u5b9a\u4f4d\u65b0\u9776\u70b9\u53d1\u73b0\u7684\u96be\u70b9\u548c\u673a\u4f1a\uff0c\u7136\u540e\u5229\u7528\u6211\u4eec\u5b9e\u9a8c\u5ba4\u4eba\u5458\u7684\u5b9e\u9a8c\u548c\u8ba1\u7b97\u4f18\u52bf\uff0c\u628a\u524d\u6cbf\u7684\u5355\u7ec6\u80de\u6280\u672f\u6709\u6548\u5730\u5e94\u7528\u5230\u80bf\u7624\u4e0a\uff0c\u628a\u6700\u65b0\u6700\u6df1\u5165\u7684\u751f\u7269\u4fe1\u606f\u65b9\u6cd5\u7528\u4e8e\u5927\u91cf\u7684\u5355\u7ec6\u80de\u6d4b\u5e8f\u6570\u636e\u4e0a\uff0c\u6700\u7ec8\u8ba9\u8fd9\u4e9b\u9ad8\u8d28\u91cf\u7684\u6570\u636e\u5f15\u5bfc\u6211\u4eec\u5f97\u5230\u65b0\u7684\u751f\u7269\u5b66\u53d1\u73b0\u3002<\/div>\n
\u672a\u6765\u7684\u79d1\u5b66\u662f\u671d\u7740\u5927\u79d1\u5b66\u7684\u65b9\u5411\u8d70\u7684\uff0c\u6211\u4eec\u73b0\u5728\u5b9e\u9a8c\u5ba4\u8fd9\u6837\u7684\u505a\u6cd5\u4e5f\u662f\u4e3a\u4e86\u5b66\u751f\u4eec\u521b\u9020\u4e86\u4e00\u4e2a\u591a\u65b9\u4f4d\u5408\u4f5c\u7684\u73af\u5883\uff0c\u8ba9\u4ed6\u4eec\u5c3d\u65e9\u9002\u5e94\u8fd9\u6837\u7684\u5927\u79d1\u5b66\u9700\u8981\uff0c\u5bf9\u5b66\u751f\u4e5f\u662f\u5f88\u597d\u7684\u953b\u70bc\u3002\u603b\u4e4b\uff0c\u8fd9\u6837\u7684\u4ea7\u3001\u5b66\u3001\u7814\u3001\u533b\u7684\u51e0\u65b9\u9762\u5408\u4f5c\u6a21\u5f0f\u662f\u53cc\u8d62\u548c\u591a\u8d62\u7684\u6a21\u5f0f\uff0c\u6211\u4eec\u5c06\u7ee7\u7eed\u6309\u8fd9\u6761\u8def\u8d70\u4e0b\u53bb\uff0c\u4e5f\u5e0c\u671b\u5176\u4ed6\u5b9e\u9a8c\u5ba4\u4ece\u8fd9\u65b9\u9762\u8003\u8651\u3002<\/div>\n
\u00a0<\/div>\n
6\u3001\u836f\u7269\u9776\u70b9\u548c\u65b0\u836f\u7814\u53d1\u7684\u843d\u5730<\/div>\n
\u00b7 Hobit\uff08ZNF683\uff09\u662fCD8 TIL\u7684\u4e00\u4e2a\u6807\u5fd7<\/div>\n
\u00b7 \u65b0\u836f\u7269\u9776\u70b9<\/div>\n
\u00b7 TCR\u53ef\u80fd\u5bf9CAR-T\u5f00\u53d1\u6709\u6307\u5bfc\u610f\u4e49<\/div>\n
\u3010\u57fa\u56e0\u6167\u3011PD -L1 \u836f\u7269\u5df2\u7ecf\u8fdb\u5165\u4e2d\u56fd\uff0c\u76f8\u4fe1 CAR -T\u836f\u7269\u4e5f\u5373\u5c06\u8fdb\u5165\u3002\u8fd9\u6b21\u7814\u7a76\u4e2d\u53d1\u73b0\u7684\u201c\u8017\u7aed\u524d\u201d\u7ec6\u80de\u53ef\u4ee5\u4f5c\u4e3a\u80ba\u817a\u764c\u6807\u5fd7\u7269\u5417\uff0c\u8ddd\u79bb\u836f\u7269\u9776\u70b9\u548c\u65b0\u836f\u7814\u53d1\u8fd8\u6709\u54ea\u4e9b\u843d\u5730\u8def\u5f84\u548c\u591a\u4e45\u5468\u671f\u5462\uff1f<\/div>\n
\u3010\u5f20\u56ed\u56ed\u3011\u6211\u4eec\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u8017\u7aed\u524dT\u7ec6\u80de\uff0c\u4e5f\u5c31\u662fHobit-hi TRM\u76f8\u5bf9\u6bd4\u4f8b\u9ad8\u7684\u60a3\u8005\u6709\u66f4\u597d\u7684\u9884\u540e\uff0cHobit\uff08ZNF683\uff09\u662f\u8fd9\u7fa4CD8 TIL\u7684\u6bd4\u8f83\u597d\u7684\u4e00\u4e2a\u6807\u5fd7\u3002\u6211\u4eec\u89c9\u5f97\u503c\u5f97\u5bf9\u8fd9\u7fa4\u7ec6\u80de\u3001\u8017\u7aedT\u7ec6\u80de\u4ee5\u53ca\u5b83\u4eec\u4e4b\u95f4\u7684\u5173\u7cfb\u505a\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u3002<\/div>\n
\u3010\u80e1\u5b66\u8fbe\u535a\u58eb\u3011\uff08\u5f20\u6559\u6388\u8bfe\u9898\u7ec4\u7684\u526f\u7814\u7a76\u5458\uff0c\u6307\u5bfc\u6e7f\u5b9e\u9a8c\uff09\u6211\u4eec\u5df2\u7ecf\u6839\u636e\u8017\u7aedT\u7ec6\u80de\u3001\u6fc0\u6d3b\u6001\u7684\u8c03\u8282T\u7ec6\u80de\u7684\u8868\u8fbe\u7279\u5f81\u63d0\u51fa\u4e86\u4e00\u4e9b\u836f\u7269\u9776\u70b9\uff0c\u5176\u4e2d\u4e00\u4e9b\u5df2\u7ecf\u6709\u5408\u4f5c\u65b9\u6b63\u5728\u5f00\u5c55\u4e0b\u6e38\u7684\u5b9e\u9a8c\u3002\u6211\u4eec\u4e5f\u5728\u6d4b\u8bd5\u548c\u7b5b\u9009\u80bf\u7624\u6297\u539f\u7279\u5f02\u7684TCR\uff0c\u8fd9\u4e9bTCR\u6709\u53ef\u80fd\u5bf9CAR-T\u7684\u5f00\u53d1\u6709\u6307\u5bfc\u610f\u4e49\u3002<\/div>\n
\u00a0<\/div>\n
7\u3001\u5355\u7ec6\u80de\u7814\u7a76\u7684\u4ea7\u7814\u533b\u534f\u4f5c<\/div>\n
\u00b7 \u5b9e\u9a8c\u6d41\u7a0b\u548c\u6280\u672f\u6807\u51c6\u5316<\/div>\n
\u00b7 \u63d0\u9ad8\u5355\u7ec6\u80de\u5b9e\u9a8c\u7ed3\u679c\u7a33\u5b9a\u6027<\/div>\n
\u00b7 \u6574\u5408\u4e0d\u540c\u6280\u672f\u5e73\u53f0\u4ea7\u751f\u7684\u5355\u7ec6\u80de\u6d4b\u5e8f\u6570\u636e<\/div>\n
\u3010\u57fa\u56e0\u6167\u3011\u5355\u7ec6\u80de\u7814\u7a76\u6b63\u5728\u4ece\u79d1\u7814\u8d70\u5411\u4ea7\u4e1a\u5316\u3002\u5728\u60a8\u79d1\u7814\u8fc7\u7a0b\u4e2d\uff0c\u5bf9\u4e8e\u5355\u4e2a\u5355\u7ec6\u80de\u5206\u79bb\u3001\u9274\u522b\u3001\u805a\u7c7b\u7b49\u5b9e\u9a8c\u548c\u6570\u636e\u5206\u6790\uff0c\u60a8\u8ba4\u4e3a\u8fd8\u5b58\u5728\u54ea\u4e9b\u6311\u6218\uff0c\u9700\u8981\u4ea7\u4e1a\u65b9\u548c\u79d1\u7814\u3001\u4e34\u5e8a\u5982\u4f55\u534f\u4f5c\u653b\u514b\u96be\u5173\uff1f<\/div>\n
\u3010\u4efb\u4ed9\u6587\u535a\u58eb\u3011\uff08\u5f20\u6559\u6388\u8bfe\u9898\u7ec4\u7684\u526f\u7814\u7a76\u5458\u3001\u6307\u5bfc\u751f\u7269\u4fe1\u606f\u5206\u6790\uff09\u5355\u7ec6\u80de\u6280\u672f\u73b0\u5728\u53d1\u5c55\u5f97\u7279\u522b\u5feb\uff0c\u4e5f\u5e26\u6765\u5f88\u591a\u524d\u6240\u672a\u6709\u7684\u6311\u6218\uff0c\u5305\u62ec\u5b9e\u9a8c\u6280\u672f\u65b9\u9762\u7684\u548c\u6570\u636e\u5206\u6790\u65b9\u9762\u7684\u3002<\/div>\n
\u5b9e\u9a8c\u6280\u672f\u65b9\u9762\uff0c\u56e0\u4e3a\u662f\u9ad8\u7cbe\u5c16\u6280\u672f\uff0c\u5355\u4e2a\u7ec6\u80de\u7684\u5206\u79bb\u3001\u6355\u83b7\uff0cRNA \/ DNA\u7684\u6269\u589e\u7b49\u6b65\u9aa4\u5f80\u5f80\u4f1a\u5b58\u5728\u660e\u663e\u7684\u6279\u6b21\u6548\u5e94\u3002\u5982\u4f55\u901a\u8fc7\u5b9e\u9a8c\u6d41\u7a0b\u548c\u6280\u672f\u7684\u6807\u51c6\u5316\u6765\u63d0\u9ad8\u5355\u7ec6\u80de\u5b9e\u9a8c\u7ed3\u679c\u7684\u7a33\u5b9a\u6027\u3001\u51cf\u5f31\u6279\u6b21\u6548\u5e94\uff0c\u6211\u60f3\u9700\u8981\u4ea7\u4e1a\u65b9\u548c\u79d1\u7814\u3001\u4e34\u5e8a\u591a\u65b9\u8fdb\u884c\u534f\u4f5c\u6765\u653b\u514b\u96be\u5173\u3002<\/div>\n
\u6570\u636e\u5206\u6790\u65b9\u9762\uff0c\u76ee\u524d\u7684\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u6570\u636e\u6709\u6bd4\u8f83\u9ad8\u7684\u7f3a\u5931\u7387\uff0c\u4e0d\u540c\u7684\u5355\u7ec6\u80de\u6d4b\u5e8f\u6280\u672f\u4e4b\u95f4\u7f3a\u5931\u7387\u4e5f\u76f8\u5dee\u8f83\u5927\u3002\u5982\u4f55\u5229\u7528\u8ba1\u7b97\u7684\u65b9\u6cd5\u8865\u5168\u7f3a\u5c11\u7684\u6570\u636e\uff0c\u5982\u4f55\u901a\u8fc7\u6807\u51c6\u5316\u6765\u6574\u5408\u4e0d\u540c\u6280\u672f\u5e73\u53f0\u4ea7\u751f\u7684\u5355\u7ec6\u80de\u6d4b\u5e8f\u6570\u636e\u662f\u5f53\u524d\u9762\u4e34\u7684\u91cd\u8981\u6280\u672f\u96be\u9898\u3002\u968f\u7740\u5355\u7ec6\u80de\u6d4b\u5e8f\u7684\u5e7f\u6cdb\u5e94\u7528\uff0c\u5355\u7ec6\u80de\u6d4b\u5e8f\u7684\u6570\u636e\u91cf\u4e5f\u6b63\u5728\u4ee5\u51e0\u4f55\u7ea7\u6570\u7684\u901f\u7387\u5728\u589e\u957f\uff0c\u5982\u4f55\u5feb\u901f\u3001\u51c6\u786e\u5730\u5206\u6790\u6570\u636e\uff0c\u4ece\u4e2d\u83b7\u5f97\u751f\u7269\u5b66\u5bb6\u3001\u4e34\u5e8a\u5927\u592b\u611f\u5174\u8da3\u7684\u7ed3\u679c\uff0c\u4e5f\u662f\u4ea7\u4e1a\u65b9\u3001\u79d1\u7814\u3001\u4e34\u5e8a\u4e09\u65b9\u534f\u4f5c\u653b\u5173\u7684\u5951\u5408\u70b9\u3002<\/div>\n
\u4e34\u5e8a\u662f\u533b\u5b66\u7814\u7a76\u7684\u8d77\u70b9\u548c\u7ec8\u70b9\uff0c\u79d1\u7814\u65b9\u4e3b\u8981\u8d1f\u8d23\u79d1\u5b66\u95ee\u9898\u3001\u7814\u7a76\u65b9\u6848\u7684\u628a\u63e1\uff0c\u800c\u4ea7\u4e1a\u65b9\u53ef\u4ee5\u5e26\u6765\u6807\u51c6\u548c\u6548\u7387\uff0c\u4e09\u65b9\u5408\u4f5c\u4e3a\u89e3\u51b3\u8fd9\u4e9b\u95ee\u9898\u63d0\u4f9b\u4e86\u6709\u5229\u6761\u4ef6\u3002<\/div>\n
\u00a0<\/div>\n
8\u3001\u5355\u7ec6\u80de\u6280\u672f\u53d1\u5c55\u8d8b\u52bf\u4e0e\u5e94\u7528\u524d\u666f<\/div>\n
\u00b7 \u672a\u6765\u5c06\u5b9e\u73b0\u540c\u4e00\u4e2a\u7ec6\u80de\u7684\u591a\u7ec4\u5b66\u6d4b\u5e8f<\/div>\n
\u00b7 \u5bf9\u7ec6\u80de\u7a7a\u95f4\u5c5e\u6027\u548c\u76f8\u4e92\u4f5c\u7528\u6d4b\u5b9a<\/div>\n
\u00b7 \u4e0e\u8367\u5149\u6807\u8bb0\u3001\u663e\u5fae\u5207\u5272\u7b49\u6280\u672f\u7ed3\u5408<\/div>\n
\u00b7 \u80bf\u7624\u3001\u751f\u6b96\u3001\u514d\u75ab\u7b49\u591a\u9886\u57df\u5e94\u7528<\/div>\n
\u3010\u57fa\u56e0\u6167\u3011\u5355\u7ec6\u80de\u662f\u751f\u547d\u79d1\u5b66\u4ece\u9ad8\u901a\u91cf\u8d70\u5411\u9ad8\u7cbe\u5ea6\u7684\u53c8\u4e00\u8de8\u8d8a\uff0c\u4f5c\u4e3a\u4e1a\u5185\u4e13\u5bb6\uff0c\u60a8\u8ba4\u4e3a\u5355\u7ec6\u80de\u6280\u672f\u53d1\u5c55\u8d8b\u52bf\u548c\u5e94\u7528\u524d\u666f\u662f\u600e\u6837\u7684\uff1f<\/div>\n
\u3010\u5f20\u6cfd\u6c11\u6559\u6388\u3011\u7ec6\u80de\u662f\u751f\u547d\u7684\u57fa\u672c\u5355\u5143\u3002\u6beb\u65e0\u7591\u95ee\uff0c\u5355\u7ec6\u80de\u6280\u672f\u5c06\u4f1a\u5f15\u9886\u65b0\u4e00\u6ce2\u57fa\u7840\u548c\u4e34\u5e8a\u533b\u5b66\u7684\u6280\u672f\u9769\u547d\u3002\u76ee\u524d\u6bd4\u8f83\u6210\u719f\u7684\u5355\u7ec6\u80de\u6d4b\u5e8f\u6280\u672f\u4e3b\u8981\u8fd8\u662f\u57fa\u56e0\u7ec4\u548c\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\uff0c\u672a\u6765\u7684\u53d1\u5c55\u8d8b\u52bf\u5c06\u5b9e\u73b0\u9ad8\u901a\u91cf\u7684\u8868\u89c2\u9057\u4f20\u7ec4\u7684\u5355\u7ec6\u80de\u6d4b\u5e8f\uff0c\u5b9e\u73b0\u540c\u4e00\u4e2a\u7ec6\u80de\u7684\u591a\u7ec4\u5b66\u6d4b\u5e8f\uff0c\u4e5f\u5c31\u662f\u5728\u57fa\u56e0\u7ec4\u3001\u8f6c\u5f55\u7ec4\u3001\u8868\u89c2\u9057\u4f20\u7ec4\u751a\u81f3\u5305\u62ec\u86cb\u767d\u8d28\u7ec4\u7b49\u591a\u4e2a\u5c42\u9762\u5b9e\u73b0\u5bf9\u540c\u4e00\u4e2a\u7ec6\u80de\u8fdb\u884c\u68c0\u6d4b\u3002<\/div>\n
\u00a0<\/div>\n
\u901a\u8fc7\u4e0e\u5176\u4ed6\u6280\u672f\u6bd4\u5982\u8367\u5149\u6807\u8bb0\u3001\u663e\u5fae\u5207\u5272\u7b49\u7ed3\u5408\uff0c\u5355\u7ec6\u80de\u6280\u672f\u751a\u81f3\u53ef\u4ee5\u5b9e\u73b0\u5bf9\u4e00\u5757\u7ec4\u7ec7\u4e2d\u6240\u6709\u7ec6\u80de\u7684\u7a7a\u95f4\u5c5e\u6027\u548c\u76f8\u4e92\u4f5c\u7528\u7684\u6d4b\u5b9a\u3002\u76ee\u524d\u8fd9\u4e9b\u6280\u672f\u90fd\u5df2\u7ecf\u51fa\u73b0\u4e86\u975e\u5e38\u597d\u7684\u82d7\u5934\uff0c\u968f\u7740\u65f6\u95f4\u63a8\u79fb\uff0c\u5b83\u4eec\u5fc5\u7136\u4f1a\u65e5\u8d8b\u6210\u719f\uff0c\u5728\u80bf\u7624\u3001\u751f\u6b96\u3001\u514d\u75ab\u7b49\u7b49\u8bb8\u591a\u751f\u7269\u533b\u5b66\u9886\u57df\u4e2d\u90fd\u4f1a\u5f97\u5230\u5e7f\u6cdb\u7684\u5e94\u7528\uff0c\u89e3\u51b3\u4e00\u6279\u7528\u4f20\u7edf\u6280\u672f\u4e0d\u80fd\u89e3\u51b3\u7684\u95ee\u9898\u3002\u4e2d\u56fd\u6210\u8bed\u201c\u5982\u864e\u6dfb\u7ffc\u201d\u8bf4\u5f97\u597d\uff0c\u4f20\u7edf\u6280\u672f\u5982\u540c\u662f\u201c\u864e\u201d\uff0c\u5355\u7ec6\u80de\u6280\u672f\u5219\u662f\u201c\u7ffc\u201d\uff0c\u5355\u7ec6\u80de\u6280\u672f\u7684\u53d1\u5c55\u4f1a\u7ed9\u8bb8\u591a\u7684\u4f20\u7edf\u6280\u672f\u6dfb\u4e0a\u201c\u7ffc\u201d\uff0c\u8fdb\u800c\u5f15\u53d1\u751f\u7269\u533b\u5b66\u9886\u57df\u7684\u9769\u547d\u3002<\/div>\n
\u3010\u611f\u8c22\u5f20\u6559\u6388\u56e2\u961f\u63a5\u53d7\u57fa\u56e0\u6167\u4e13\u8bbf\uff0c\u79d1\u7814\u6210\u679c\u7b2c\u4e00\u4f5c\u8005\u514d\u8d39\u4e13\u8bbf\uff0c\u6b22\u8fce\u8054\u7cfb\u6211\u4eec info@genonet.cn, 400-088-7466 \u3011<\/div>\n
\u00a0<\/div>\n
\u63a8\u8350\u9605\u8bfb<\/div>\n
\u72ec\u5bb6\u4e13\u8bbf\u300aCell\u300b\u4e2d\u56fd\u5b66\u8005\u9996\u6b21\u53d1\u5e03\u5927\u89c4\u6a21\u80bf\u7624\u5355\u7ec6\u80de\u6c34\u5e73\u514d\u75ab\u56fe\u8c31<\/a><\/div>\n
\u4ece150\u5e74\u524d\u5f00\u59cb\uff0c\u957f\u8c08\u80bf\u7624\u514d\u75ab\u6cbb\u7597<\/a><\/div>\n
\u57fa\u56e0\u6d4b\u5e8f\u6280\u672f\u4ea7\u4e1a\u5316\u5341\u5e74\u7b80\u62a5\uff08\u8282\u9009\uff09<\/a><\/div>\n\n
\n
\"fgnkxfGnnkR81iaOnJJia1zFc2NdhJfk3tqapGF7fiaFzyuAsRsbcdZYzPLsicOaRxGXpTCGrDy6gMw047o5xfaicQg\"\/<\/figure><\/div>\n\n
\u65b0\u5a92\u4f53\u7f16\u8f91<\/div>\n
\u4e13\u680f\u4f5c\u8005<\/div>\n
\u884c\u4e1a\u5206\u6790\u5e08<\/div>\n
\u25bc\u00a0\u9996\u4e2a\u6570\u5b57\u751f\u547d\u5065\u5eb7\u4ea7\u4e1a\u5927\u6570\u636e\u5e73\u53f0<\/div>\n\n
\n
\"RmFicvQBAkgD3hqjicINHF4d4PO2yyQOJAGMAY6MkRTt9L8Wuc19UC3IjW9sSrhPiaEuDmbwFLibFOIDdUkrsAUmibQ\"\/<\/figure><\/div>\n\n

<\/a><\/div>\n

<\/div>\n
<\/div>\n
\u5173\u4e8e\u57fa\u56e0\u6167<\/div>\n
GeneClub<\/div>\n
\u57fa\u56e0\u6167\u662f\u6570\u5b57\u751f\u547d\u5065\u5eb7\u9886\u57df\u4e13\u4e1a\u7684\u79d1\u6280\u5a92\u4f53\u548c\u54a8\u8be2\u673a\u6784\u3002\u57fa\u4e8e\u6df1\u8015\u5341\u5e74\u7684\u4e13\u4e1a\u6027\uff0c\u6211\u4eec\u81f4\u529b\u4e8e\u5efa\u7acb\u884c\u4e1a\u4fe1\u7528\u8bc4\u7ea7\u548c\u51b3\u7b56\u54a8\u8be2\u7684\u5927\u6570\u636e\u5e73\u53f0\uff0c\u4e3a\u533b\u7597\u5065\u5eb7\u7b49\u673a\u6784\u63d0\u4f9b\u79d1\u666e\u5ba3\u4f20\u3001\u884c\u7814\u54a8\u8be2\u548c\u4ea7\u4e1a\u94fe\u63a5\u670d\u52a1\uff0c\u8d4b\u80fd\u4ea7\u5b66\u653f\u7684\u878d\u5408\uff0c\u4f7f\u8fde\u63a5\u4ea7\u751f\u4ef7\u503c\uff0c\u7528\u6570\u636e\u51b3\u7b56\u672a\u6765\u3002\u00a0<\/div>\n
<\/div>\n
\u57fa\u56e0\u6167\u4f5c\u4e3a\u201c\u5341\u4e09\u4e94\u201d\u91cd\u70b9\u56fe\u4e66\u300a\u4e34\u5e8a\u751f\u7269\u6837\u672c\u5e93\u7684\u63a2\u7d22\u4e0e\u5b9e\u8df5\u300b\u7f16\u59d4\u5355\u4f4d\uff0c\u5e7f\u4e1c\u7701\u7cbe\u51c6\u533b\u5b66\u5b66\u4f1a\u9057\u4f20\u75c5\u5206\u4f1a\u5e38\u59d4\u5355\u4f4d\u3001\u6df1\u5733\u5e02\u5065\u5eb7\u4ea7\u4e1a\u53d1\u5c55\u4fc3\u8fdb\u4f1a\u526f\u4f1a\u957f\u5355\u4f4d\uff0c\u5728\u884c\u4e1a\u5927\u4f1a\u4e0a\u53d1\u5e03\u4e86\u300a2018\u5e74\u57fa\u56e0\u884c\u4e1a\u521b\u6295\u62a5\u544a\u300b\u7b49\u6570\u4e2a\u62a5\u544a\uff08\u8be6\u60c5<\/a>\uff09\uff0c\u53c2\u4e0e\u7ec4\u7ec7\u9996\u4e2a\u300a\u4e34\u5e8a\u57fa\u56e0\u68c0\u6d4b\u62a5\u544a\u89c4\u8303\u4e0e\u57fa\u56e0\u68c0\u6d4b\u884c\u4e1a\u5171\u8bc6\u300b\u843d\u5730\uff08\u8be6\u60c5<\/a>\uff09\uff0c\u4e3b\u529e\u4e86\u9996\u5c4a\u6570\u5b57\u5065\u5eb7\u79c1\u8463\u4f1a\uff08\u8be6\u60c5<\/a>\uff09\uff0c\u4e3a\u653f\u5e9c\u548c\u4ea7\u4e1a\u51b3\u7b56\u8005\u63d0\u4f9b\u884c\u4e1a\u54a8\u8be2\u548c\u5e02\u573a\u8c03\u7814\u670d\u52a1\u3002<\/div>\n
<\/div>\n
<\/div>\n
<\/div>\n
\n\n
\n
\"RmFicvQBAkgARAxOYCIZZU5x7thFZD30NplPWNIRQIwHXEyEnYnCG8lq70UINNglNWWjGrRXibHD992FlLoXZHAg\"\/<\/figure><\/div>","protected":false},"excerpt":{"rendered":"

\u57fa\u56e0\u6167\u4e13\u8bbf\u5317\u4eac\u5927\u5b66\u5f20\u6cfd\u6c11\u5b9e\u9a8c\u5ba4\u56e2\u961f<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[1928,1801,1738],"class_list":["post-9688","post","type-post","status-publish","format-standard","hentry","category-thinktank","tag-t","tag-1801","tag-1738"],"_links":{"self":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/9688","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/comments?post=9688"}],"version-history":[{"count":3,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/9688\/revisions"}],"predecessor-version":[{"id":14124,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/9688\/revisions\/14124"}],"wp:attachment":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/media?parent=9688"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/categories?post=9688"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/tags?post=9688"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}