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src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCuC54K47siaoibvbClYbpoQdmoEA7Yo9T0l4l5c9wsK8DWv13zXvBYojNDUX4HpbxOEe8enSicCuVVg.gif\" alt=\"RmFicvQBAkgCuC54K47siaoibvbClYbpoQdmoEA7Yo9T0l4l5c9wsK8DWv13zXvBYojNDUX4HpbxOEe8enSicCuVVg\"\/><\/figure><\/div>\n\n<\/div>\n<div><\/div>\n<div>\u5173\u952e\u8bcd\/\u57fa\u56e0\u6d4b\u5e8f\u4e34\u5e8a\u5e94\u7528 \u89c4\u8303 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class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDtjXsEYibX7SY8zvu0kuWI9j7iadsf53mtpMIYHXCoUS2RvvgibMlEGsjK6nFM2TBUp8lEhGH5pX3QQ.jpeg\" alt=\"RmFicvQBAkgDtjXsEYibX7SY8zvu0kuWI9j7iadsf53mtpMIYHXCoUS2RvvgibMlEGsjK6nFM2TBUp8lEhGH5pX3QQ\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u5317\u4eac\u57fa\u56e0\u7ec4\u7814\u7a76\u6240\u4e8e\u519b\u6559\u6388<\/div>\n<div>\u4e2d\u56fd\u79d1\u5b66\u9662\u5317\u4eac\u57fa\u56e0\u7ec4\u7814\u7a76\u6240\u4e8e\u519b\u6559\u6388\u5728\u300a\u73b0\u4ee3\u751f\u547d\u79d1\u5b66\u4e0e\u6280\u672f\u524d\u6cbf\u7684\u601d\u8003\u300b\u62a5\u544a\u4e2d\uff0c\u4ece\u7cfb\u7edf\u751f\u7269\u5b66\u3001\u5206\u5b50\u751f\u7269\u5b66\u5230\u5173\u952e\u57fa\u56e0\u7ec4\u6280\u672f\u4ee5\u53ca\u591a\u6d41\u7cfb\u7edf\u7b49\u5b8f\u89c2\u89d2\u5ea6\uff0c\u5206\u4eab\u4e86\u5bf9\u4e8e\u751f\u547d\u79d1\u5b66\u7684\u524d\u6cbf\u8ba4\u77e5\u3002\u5185\u5bb9\u6458\u8981\u5982\u4e0b\uff1a<\/div>\n<div>1\uff09\u5bf9\u751f\u7269\u5b66\u7684\u601d\u8003\u7ef4\u5ea6\uff0c\u4e00\u65b9\u9762\u4ece\u5b5f\u5fb7\u5c14\u9057\u4f20\u3001\u8fbe\u5c14\u6587\u7684\u81ea\u7136\u9009\u62e9\u5230\u73b0\u4ee3\u751f\u7269\u5b66\uff1b\u53e6\u4e00\u65b9\u9762\u4ece\u89c2\u5bdf\u751f\u7269\u5b66\u3001\u7cfb\u7edf\u751f\u7269\u5b66\u5230\u5206\u5b50\u751f\u7269\u5b66\u3002<\/div>\n<div>2\uff09\u5b8f\u89c2\u751f\u7269\u5708\u548c\u7eb3\u7c73\u5c3a\u5ea6\u7684\u6d4b\u91cf\u4ece\u4e24\u4e2a\u6781\u70b9\u62d3\u5bbd\u751f\u7269\u5b66\u7814\u7a76\u89d2\u5ea6\u3002<\/div>\n<div>3\uff09\u57fa\u56e0\u7ec4\u5206\u5b50\u751f\u7269\u5b66\u4e4b\u591a\u6d41\u7cfb\u7edf\uff1a \u4fe1\u606f\u6d41\u3001\u64cd\u4f5c\u6d41\u3001\u5e73\u8861\u6d41\u3001\u5206\u5ba4\u6d41\u548c\u53ef\u5851\u6d41\u3002<\/div>\n<div>4\uff09\u5173\u952e\u57fa\u56e0\u7ec4\u6280\u672f\u53d1\u5c55\u5305\u62ec\uff1aDNA\u6742\u4ea4\u3001Sanger\u6d4b\u5e8f\u6280\u672f\u3001\u5be1\u6838\u82f7\u9178\u5408\u6210\u3001PCR\u3001\u5fae\u9635\u5217\uff08\u57fa\u56e0\u82af\u7247\uff09\u3001DNA\u6d4b\u5e8f\u4eea\u3001NGS\u6280\u672f\u3001\u5355\u5206\u5b50\u6d4b\u5e8f\u7b49\u3002<\/div>\n<div>5\uff09RNA\u76f4\u6d4b\u5b9e\u73b0\u5b9a\u6027\u3001\u5b9a\u4f4d\u3001\u5b9a\u91cf\u548c\u5b9a\u65f6\uff0c\u63a8\u52a8\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u4ece\u5dee\u5f02\u5c55\u793a\u3001\u8868\u8fbe\u6807\u7b7e\u3001RNA\u8868\u9762\u9635\u5217\u3001\u9ad8\u901a\u91cfcDNA\u6d4b\u5e8f\u5230RNA\u76f4\u6d4b\u3002<\/div>\n<div>6\uff09\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u4e4b\u540e\uff0c\u8bf8\u591a\u7a7a\u95f4\u9700\u8981\u5f00\u53d1\uff0c\u5305\u62ec\u4eba\u7c7b\u7ec6\u80deRNA\u7ec4\u8ba1\u5212\u3001\u4eba\u7c7b\u5168\u7ec6\u80de\u7ec4\u8ba1\u5212\u3001\u4eba\u7c7b\u7ec4\u7ec7\u5668\u5b98\u7ec4\u8ba1\u5212\u3001\u4eba\u7c7b\u751f\u7406\u75c5\u7406\u7ec4\u8ba1\u5212\u7b49\u3002<\/div>\n<div>\u00a0<\/div>\n<div>3\u3001\u57fa\u56e0\u6d4b\u5e8f\u4e34\u5e8a\u5e94\u7528\u524d\u6cbf\u8bba\u575b\uff0c\u7279\u9080\u62a5\u544a<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDtjXsEYibX7SY8zvu0kuWI9HbyFvic6sXGKCjwrx9gLkriaVwjAQ7icGRaodPtaalbK8w4BibuQDDEsNw.jpeg\" alt=\"RmFicvQBAkgDtjXsEYibX7SY8zvu0kuWI9HbyFvic6sXGKCjwrx9gLkriaVwjAQ7icGRaodPtaalbK8w4BibuQDDEsNw\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe\uff0c\u6d59\u6c5f\u5927\u5b66\u9644\u5c5e\u5987\u4ea7\u79d1\u533b\u9662\u8463\u65fb\u5cb3\u4e3b\u4efb<\/div>\n<div>\u6d59\u6c5f\u5927\u5b66\u9644\u5c5e\u5987\u4ea7\u79d1\u533b\u9662\u8463\u65fb\u5cb3\u4e3b\u4efb\u5728\u5927\u4f1a\u4e0a\u5206\u4eab\u4e86\u300aNIPT\uff1a\u73b0\u72b6\u4e0e\u671f\u671b\u300b\u62a5\u544a\uff0c\u4ece\u4e00\u7ebf\u4e34\u5e8a\u533b\u751f\u5b9e\u8df5\u548c\u5168\u56fd\u8bd5\u70b9\u5355\u4f4d\u7684\u6570\u636e\u7edf\u8ba1\u7b49\u89d2\u5ea6\u68b3\u7406\u4e86\u65e0\u521b\u4ea7\u524d\u57fa\u56e0\u8bca\u65ad\uff08NIPT\uff09\u7684\u57fa\u7840\u903b\u8f91\u548c\u601d\u8003\u3002\u5185\u5bb9\u6458\u8981\u5982\u4e0b\uff1a<\/div>\n<div>1\uff09\u4ea7\u524d\u9057\u4f20\u75c5\u8bca\u65ad\u8303\u56f4\uff1a\u67d3\u8272\u4f53\u75c5\uff0c\u5305\u62ec\u5e38\u89c1\u975e\u6574\u500d\u4f53\uff08T21\u3001T18\u3001T13\uff09\u3001\u6027\u67d3\u8272\u4f53\u5f02\u5e38\uff08XO\u3001XXX\u3001XXY\u3001XYY\uff09\u3001\u5176\u4ed6\uff08T8\u3001T16\u7b49\uff09\u3001\u57fa\u56e0\u7ec4\u75c5(\u5fae)\u7f3a\u5931\u548c(\u5fae)\u91cd\u590d\u4ee5\u53ca\u5355\u57fa\u56e0\u75c5\u7b49\u3002<\/div>\n<div>2\uff09NIPT\u89e3\u51b3\u4e86\u8840\u6e05\u5b66\u7b5b\u67e5\u4e2d\u7684\u5f88\u591a\u95ee\u9898\uff0c\u6bd4\u5982\u53ef\u4ee5\u53d1\u73b0\u6027\u67d3\u8272\u4f53\u5f02\u5e38\uff0c\u57fa\u56e0\u5fae\u7f3a\u5931\u548c\u5fae\u91cd\u590d\u3001\u66f4\u4f4e\u7684\u5047\u9633\u6027\u7387\u4ece\u800c\u51cf\u5c11\u4e0d\u5fc5\u8981\u7684\u6709\u521b\u4ea7\u524d\u8bca\u65ad\u3001\u66f4\u5bbd\u6cdb\u7684\u7b5b\u67e5\u5b55\u5468\u3001\u66f4\u4f4e\u5047\u9634\u6027\u7387\u3002\u4f46\u4e5f\u5b58\u5728\u4e00\u4e9b\u95ee\u9898\u3002\u4f8b\u5982\uff1a\u57fa\u56e0\u7ec4\u5fae\u7f3a\u5931\u3001\u5fae\u91cd\u590d\u7684\u9633\u6027\u9884\u6d4b\u503c\u4f4e\uff0c\u68c0\u51fa\u7387\u96be\u4ee5\u8bc4\u4f30\u7b49\u3002<\/div>\n<div>3\uff09\u6839\u636e2014\u5e7440\u5bb6\u8bd5\u70b9\u5355\u4f4d\u7684126425\u4f8b\u6570\u636e\u7edf\u8ba1\u663e\u793a\uff0cT21\uff08\u5510\u6c0f\u7efc\u5408\u5f81\uff09\u7684\u9633\u6027\u9884\u6d4b\u503c\u4e3a87.1%\uff0c\u68c0\u51fa\u7387\u4e3a99.1%\uff0c\u5047\u9633\u6027\u7387\u4e3a0.05%\u3002\u6574\u4f53\u800c\u8a00\uff0c\u9633\u6027\u9884\u6d4b\u503c\u9ad8\uff0c\u5047\u9633\u6027\u7387\u4f4e\uff080.05%\uff09\uff0c\u5047\u9634\u6027\u7387\u4f4e\uff083\/10\u4e07\uff09\u3002\u4f46T18\u548cT13\u7684\u9633\u6027\u9884\u6d4b\u503c\u504f\u4f4e\u3002<\/div>\n<div>4\uff09\u5355\u5206\u5b50\u6d4b\u5e8f\u5e94\u7528\u5230NIPT\uff0c\u4f7f\u5f97\u68c0\u6d4b\u5b55\u5468\u63d0\u524d\u3001\u5e94\u7528\u8303\u56f4\u6269\u5927\uff0c\u5fae\u7f3a\u5931\u3001\u5fae\u91cd\u590d\u7684\u68c0\u51fa\u7387\u548c\u6574\u4f53PPV\u63d0\u9ad8\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDtjXsEYibX7SY8zvu0kuWI9icPRoicfhVHSNWbRRxWFG3ibIZ0r9wKSialHtXHA7jIcJ8MRN8Khfz7tKg.jpeg\" alt=\"RmFicvQBAkgDtjXsEYibX7SY8zvu0kuWI9icPRoicfhVHSNWbRRxWFG3ibIZ0r9wKSialHtXHA7jIcJ8MRN8Khfz7tKg\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe\uff0c\u5317\u4eac\u5929\u575b\u533b\u9662\u5b9e\u9a8c\u8bca\u65ad\u4e2d\u5fc3\u4e3b\u4efb\u5eb7\u7199\u96c4\u6559\u6388<\/div>\n<div>\u5317\u4eac\u5929\u575b\u533b\u9662\u5b9e\u9a8c\u8bca\u65ad\u4e2d\u5fc3\u4e3b\u4efb\u5eb7\u7199\u96c4\u6559\u6388\u5728\u300a\u533b\u7597\u5668\u68b0\u521b\u65b0\u901a\u9053\u548c\u4f18\u5148\u901a\u9053\u300b\u62a5\u544a\u4e2d\u5206\u4eab\u4e86\u533b\u7597\u5668\u68b0\u521b\u65b0\u901a\u9053\u3001\u4f18\u5148\u901a\u9053\u7684\u9002\u7528\u8303\u56f4\u5dee\u5f02\u3001\u7533\u62a5\u6d41\u7a0b\u5dee\u5f02\u548c\u5171\u6027\u95ee\u9898\u7b49\u3002\u5185\u5bb9\u6458\u8981\u5982\u4e0b\uff1a<\/div>\n<div>1\uff09\u521b\u65b0\u901a\u9053\u9002\u7528\u4e8e\u6709\u4e13\u5229\u3001\u6709\u521b\u65b0\u548c\u6709\u4ea7\u54c1\u7684\u533b\u7597\u5668\u68b0\u7279\u522b\u5ba1\u6279\uff1b\u4f18\u5148\u901a\u9053\u9002\u7528\u4e8e\u7b26\u5408\u6761\u4ef6\uff08\u4e3b\u8981\u662f\u6709\u91cd\u5927\u7528\u9014\u3001\u56fd\u5bb6\u79d1\u6280\u91cd\u5927\u4e13\u9879\u6216\u91cd\u70b9\u7814\u53d1\u7814\u53d1\u8ba1\u5212\uff09\u7684\u5883\u5185\u7b2c\u4e09\u7c7b\u548c\u8fdb\u53e3\u7b2c\u4e8c\u7c7b\u3001\u7b2c\u4e09\u7c7b\u533b\u7597\u5668\u68b0\u3002<\/div>\n<div>2\uff09\u521b\u65b0\u7279\u522b\u5ba1\u6279\u662f\u7533\u8bf7\u5df2\u5b8c\u6210\u4ea7\u54c1\u7684\u524d\u671f\u52a8\u7269\u7814\u7a76\u5e76\u5177\u6709\u57fa\u672c\u5b9a\u578b\u4ea7\u54c1\u5373\u53ef\u7533\u62a5\uff1b\u4f18\u5148\u5ba1\u6279\u662f\u7533\u62a5\u4eba\u5b8c\u6210\u4e34\u5e8a\u8bd5\u9a8c\u4e0e\u6ce8\u518c\u8d44\u6599\u51c6\u5907\u540e\uff0c\u9700\u4e0e\u6ce8\u518c\u5408\u5e76\u7533\u8bf7\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDtjXsEYibX7SY8zvu0kuWI9ILJnm7QK4bqBpI2Zs12LnglzhD1sJiaEErKVIzzjQUHxRlicdkeoMWiaQ.jpeg\" alt=\"RmFicvQBAkgDtjXsEYibX7SY8zvu0kuWI9ILJnm7QK4bqBpI2Zs12LnglzhD1sJiaEErKVIzzjQUHxRlicdkeoMWiaQ\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe\uff0c\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u5458\u4f1a\u4e34\u5e8a\u68c0\u9a8c\u4e2d\u5fc3\u674e\u91d1\u660e\u4e3b\u4efb<\/div>\n<div>\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u5458\u4f1a\u4e34\u5e8a\u68c0\u9a8c\u4e2d\u5fc3\u674e\u91d1\u660e\u4e3b\u4efb\u00a0\u5728\u5927\u4f1a\u5206\u4eab\u4e86\u300a\u5b9e\u73b0\u9ad8\u901a\u91cf\u6d4b\u5e8f\u4e34\u5e8a\u6709\u6548\u5e94\u7528\u9700\u5173\u6ce8\u7684\u6838\u5fc3\u95ee\u9898\u300b\uff0c\u4eceNGS\u6280\u672f\u672c\u8eab\u3001\u4e34\u5e8a\u5e94\u7528\u548c\u5b9e\u9a8c\u5ba4\u89c4\u8303\u7b49\u89d2\u5ea6\u8fdb\u884c\u95ee\u9898\u5f52\u7eb3\u548c\u8981\u70b9\u5206\u6790\u3002\u5185\u5bb9\u6458\u8981\u5982\u4e0b\uff1a<\/div>\n<div>1\uff09\u9700\u5173\u6ce8\u7684\u6838\u5fc3\u95ee\u9898\uff1a<\/div>\n<div>a. \u4eba\u5458\u51c6\u5907\uff1b<\/div>\n<div>b. \u5b9e\u9a8c\u5ba4\u51c6\u5907\uff1b<\/div>\n<div>c. \u4e34\u5e8a\u6709\u6548\u6027(Clinical validity)\u3001\u4e34\u5e8a\u6709\u7528\u6027(Clinical utility)\u548c\u4e34\u5e8a\u9884\u671f\u7528\u9014(Intended use) \uff1b<\/div>\n<div>d. \u5206\u6790\u524d\uff1a\u6807\u672c\u91c7\u96c6\u3001\u8fd0\u9001\u3001\u4fdd\u5b58\u53ca\u8d28\u68c0\uff1b<\/div>\n<div>e. \u65b9\u6cd5\u5efa\u7acb\uff1a\u6027\u80fd\u786e\u8ba4(\u81ea\u5efa\u65b9\u6cd5)\u6216\u6027\u80fd\u9a8c\u8bc1(\u5546\u54c1\u8bd5\u5242) ;<\/div>\n<div>f. \u8d28\u91cf\u63a7\u5236\uff1b<\/div>\n<div>g. SOPs(\u201c\u6e7f\u8bd5\u9a8c\u201d\u548c\u201c\u5e72\u8bd5\u9a8c\u201d)\u5efa\u7acb;<\/div>\n<div>h. \u5b9e\u9a8c\u5ba4\u4fe1\u606f\u7ba1\u7406\u7cfb\u7edf\u5efa\u8bbe;<\/div>\n<div>i. \u5ba2\u6237(\u533b\u751f\u6216\u533b\u9662)\u7684\u6559\u80b2\u548c\u57f9\u8bad\u3002<\/div>\n<div>2\uff09\u4e00\u4e2a\u751f\u7269\u6807\u5fd7\u7269\u53ef\u4ee5\u4f5c\u4e3a\u80bf\u7624\u65e9\u7b5b\u6216\u65e9\u8bca\u6807\u5fd7\u7269\u7684\u5fc5\u8981\u6761\u4ef6\uff1a<\/div>\n<div>a. \u68c0\u6d4b\u7ed3\u679c\u9633\u6027\u9884\u6d4b\u503c\uff08PPV\uff09\u548c\u9634\u6027\u9884\u6d4b\u503c\uff08NPV\uff09\u662f\u5df2\u77e5\u7684\uff0c\u4e14\u80fd\u8fbe\u5230\u7b5b\u67e5\u6216\u8bca\u65ad\u5e94\u7528\u7684\u6807\u51c6\uff1b<\/div>\n<div>b. \u4f5c\u4e3a\u7b5b\u67e5\uff0c\u5e94\u6709\u660e\u786e\u7684\u7b5b\u67e5\u7b56\u7565\u53ca\u5206\u5c42\u7ba1\u7406\u7684\u65b9\u6848\u3002<\/div>\n<div>3\uff09\u8840\u6e05\u80bf\u7624\u6807\u5fd7\u7269\u4e0d\u80fd\u7528\u4e8e\u666e\u901a\u4eba\u7fa4\u7684\u7b5b\u67e5\uff0c\u4f46\u5728\u4e00\u5b9a\u6761\u4ef6\u4e0b\uff0c\u53ef\u7528\u4e8e\u9ad8\u5371\u4eba\u7fa4\u7b5b\u67e5\u3002\u76ee\u524d\u5c1a\u6ca1\u6709\u4e00\u4e2a\u7279\u5b9a\u7684ctDNA\u6709\u660e\u786e\u7684PPV\u548cNPV\uff0c\u6240\u4ee5\u5c1a\u4e0d\u80fd\u7528\u4e8e\u80bf\u7624\u7b5b\u67e5\u6216\u8bca\u65ad\u3002\u8fd9\u91cc\u9700\u8003\u8651\u5230\u53d7\u68c0\u8005\u7684\u7cbe\u795e\u7126\u8651\uff0c\u6bd4\u5982\u5b55\u5987\u7684\u7126\u8651\u5e26\u6765\u7684\u884d\u751f\u75be\u75c5\u95ee\u9898\u7b49\u3002<\/div>\n<div>4\uff09NGS\u6027\u80fd\u786e\u8ba4\u5305\u62ec\u5e73\u53f0\u786e\u8ba4\u3001\u68c0\u6d4b\u65b9\u6cd5\u786e\u8ba4\u548c\u751f\u7269\u4fe1\u606f\u5b66\u5206\u6790\u786e\u8ba4\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDtjXsEYibX7SY8zvu0kuWI9b7ZTaoDlZRUcMOppg1gib4aKF3iaXXmlDVYVZZ48ZZNxgQBjzn8tuFOQ.jpeg\" alt=\"RmFicvQBAkgDtjXsEYibX7SY8zvu0kuWI9b7ZTaoDlZRUcMOppg1gib4aKF3iaXXmlDVYVZZ48ZZNxgQBjzn8tuFOQ\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe\uff0c\u81fb\u548c(\u5317\u4eac)\u79d1\u6280\u6709\u9650\u516c\u53f8\u9996\u5e2d\u6280\u672f\u5b98\u738b\u6d77\u6ce2\u535a\u58eb\u00a0<\/div>\n<div>\u81fb\u548c(\u5317\u4eac)\u79d1\u6280\u6709\u9650\u516c\u53f8\u9996\u5e2d\u6280\u672f\u5b98\u738b\u6d77\u6ce2\u535a\u58eb\u00a0\u5728\u5927\u4f1a\u5206\u4eab\u4e86\u300a\u4ef7\u503c\u533b\u7597\u4f53\u7cfb\u4e0b\u80bf\u7624\u7cbe\u51c6\u8bca\u7597\u7684\u8d28\u91cf\u8981\u6c42\u548c\u53d1\u5c55\u65b9\u5411\u300b\uff0c\u8c08\u5230\u4e86\u80bf\u7624\u7cbe\u51c6\u8bca\u7597\u7684\u4ef7\u503c\u533b\u7597\u7684\u94c1\u4e09\u89d2\u548c\u81fb\u548c\u7684NGS\u68c0\u6d4b\u5e73\u53f0\u3002\u5185\u5bb9\u6458\u8981\u5982\u4e0b\uff1a<\/div>\n<div>1\uff09\u8d28\u91cf\u4f18\u3001\u8986\u76d6\u5e7f\u3001\u4ef7\u503c\u9ad8\u662f\u80bf\u7624\u7cbe\u51c6\u8bca\u7597\u7684\u4ef7\u503c\u533b\u7597\u7684\u94c1\u4e09\u89d2\u3002\u5176\u4e2d\u8d28\u91cf\u9700\u7b26\u5408\u6280\u672f\u6807\u51c6\u3001\u884c\u4e1a\u6807\u51c6\u548c\u56fd\u5bb6\u6807\u51c6\uff1b\u8986\u76d6\u8303\u56f4\u5e7f\u5305\u62ec\u68c0\u6d4b\u8303\u56f4\u5e7f\u3001\u68c0\u6d4b\u7ef4\u5ea6\u5e7f\u548c\u8986\u76d6\u4eba\u7fa4\u5e7f\uff1b\u4ef7\u503c\u9ad8\u5305\u62ec\u4e3b\u8981\u6307\u6bd4\u4f20\u7edf\u65b9\u6848\u7684\u6210\u672c\u4f4e\uff0c\u540c\u65f6\u901a\u8fc7\u6280\u672f\u7b5b\u9009\u51fa\u6cbb\u7597\u6548\u7387\u9ad8\u7684\u60a3\u8005\u3002<\/div>\n<div>2\uff09\u81fb\u548c\u7684NGS\u68c0\u6d4b\u5e73\u53f0\u901a\u8fc7\u5bf9\u4eba\u5458\u3001\u4f9b\u5e94\u548c\u8d28\u91cf\u4fdd\u8bc1\u4f53\u7cfb\u5efa\u7acb\u4e34\u5e8a\u68c0\u9a8c\u5168\u7a0b\u7684\u4f53\u7cfb\u8d28\u91cf\u7ba1\u7406\u4fdd\u969c\u3002\u53d1\u5e03\u7684\u5168\u666fRNA-IO Panel\u8986\u76d6\u80bf\u7624\u514d\u75ab\u76f8\u5173\u768436\u4e2a\u4fe1\u53f7\u901a\u8def\uff0c\u81f4\u529b\u4e8e\u5efa\u7acb\u7cbe\u51c6\u8bca\u7597\u6838\u5fc3\u4f53\u7cfb\u4e0e\u771f\u5b9e\u4e16\u754c\u6837\u672c\u5e93\u5168\u7a0b\u5168\u9762\u4e34\u5e8a\u8f6c\u5316\u5e73\u53f0\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDtjXsEYibX7SY8zvu0kuWI9avNibnLAPLxWk6BXf0icVq8Vwj76FKQhR3JzwIvmLJUpv8ibxc1ckrjKw.jpeg\" alt=\"RmFicvQBAkgDtjXsEYibX7SY8zvu0kuWI9avNibnLAPLxWk6BXf0icVq8Vwj76FKQhR3JzwIvmLJUpv8ibxc1ckrjKw\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe\uff0c\u4e2d\u56fd\u98df\u54c1\u836f\u54c1\u68c0\u5b9a\u7814\u7a76\u9662\u9ec4\u6770\u4e3b\u4efb<\/div>\n<div>\u4e2d\u56fd\u98df\u54c1\u836f\u54c1\u68c0\u5b9a\u7814\u7a76\u9662\u9ec4\u6770\u4e3b\u4efb\u901a\u8fc7\u300a\u4e34\u5e8a\u5e94\u7528\u9ad8\u901a\u91cf\u6d4b\u5e8f\u4eea\u7684\u6027\u80fd\u8bc4\u4ef7\u300b\u62a5\u544a\uff0c\u4ecb\u7ecd\u4e86\u6d4b\u5e8f\u4eea\u76ee\u524d\u8bc4\u4ef7\u7684\u4e3b\u8981\u6027\u80fd\u6307\u6807\u548c\u672a\u6765\u53d1\u5c55\u65b9\u5411\u3002\u5185\u5bb9\u6458\u8981\u5982\u4e0b\uff1a<\/div>\n<div>1\uff09\u9ad8\u901a\u91cf\u6d4b\u5e8f\u6280\u672f\u53d1\u5c55\u3002<\/div>\n<div>a. \u9ad8\u901a\u91cf\u6d4b\u5e8f\u4eea\u5168\u7403\u5206\u5e03\uff0c\u5168\u7403\u603b\u91cf\u7ea6\u4e3a15000\u53f0\uff0c\u4e3b\u6d41\u54c1\u724c\u5305\u62ecIllumina\u3001Thermo Fisher \u3001MGI\u3001Pacific Biosciences\u7b49\u3002<\/div>\n<div>b. \u00a0\u56fd\u5185\u6d4b\u5e8f\u4eea\u7814\u53d1\u5546\u5305\u62ec\uff08\u90e8\u5206\u4e3aOEM\uff09\uff1a\u534e\u5927\u57fa\u56e0\u3001\u701a\u6d77\u57fa\u56e0\u3001\u534e\u56e0\u5eb7\u3001\u4e2d\u79d1\u7d2b\u99a8\u3001\u8d1d\u745e\u548c\u5eb7\u3001\u8fbe\u5b89\u57fa\u56e0\u3001\u535a\u5965\u751f\u7269\u3001\u5b89\u8bfa\u4f18\u8fbe\u3001\u5c0f\u6d77\u9f9f\u79d1\u6280\u7b49 \u3002<\/div>\n<div>2\uff09\u6d4b\u5e8f\u4eea\u53d1\u5c55\u65b9\u5411\uff1a \u4e00\u4f53\u5316\uff08\u9002\u7528\u4e8e\u4e34\u5e8a\u673a\u6784\uff09\uff1b \u5c0f\u578b\u5316\uff08\u9002\u7528\u4e8e\u79d1\u7814\u4e34\u5e8a\u673a\u6784\uff09\uff1b \u8d85\u9ad8\u901a\u91cf\uff08\u9002\u7528\u4e8e\u56fd\u5bb6\u57fa\u56e0\u7ec4\u4e2d\u5fc3\u3001\u5927\u89c4\u6a21\u6d4b\u5e8f\u670d\u52a1\u516c\u53f8\uff09\u3002\u00a0<\/div>\n<div>3\uff09\u57fa\u56e0\u6d4b\u5e8f\u4eea\u8bc4\u4ef7\u5305\u62ec\uff1a \u4e8c\u4ee3\u6d4b\u5e8f\u4eea\u6027\u80fd\u9a8c\u8bc1\u548c\u5b89\u5168\u6027\u9a8c\u8bc1\u4e24\u5927\u65b9\u9762\u3002<\/div>\n<div>4\uff09\u53d1\u5c55\u65b9\u5411\uff1a\u4e2d\u56fd\u4eba\u53c2\u6bd4\u57fa\u56e0\u7ec4\u5efa\u8bbe\u3001\u6807\u51c6\u7269\u8d28\u7814\u5236\u548c\u6570\u636e\u5e93\u4e92\u901a\u5171\u4eab\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDtjXsEYibX7SY8zvu0kuWI9ZPKg8yukKew7F1gOw2mFsIvXwGeCVibmGSeKMWCBtZo8icb17vMXa8iaA.jpeg\" alt=\"RmFicvQBAkgDtjXsEYibX7SY8zvu0kuWI9ZPKg8yukKew7F1gOw2mFsIvXwGeCVibmGSeKMWCBtZo8icb17vMXa8iaA\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe\uff0c\u5357\u65b9\u79d1\u6280\u5927\u5b66\u526f\u6559\u6388\u3001\u701a\u6d77\u57fa\u56e0\u8463\u4e8b\u957f\u8d3a\u5efa\u594e\u526f\u6559\u6388<\/div>\n<div>\u5357\u65b9\u79d1\u6280\u5927\u5b66\u526f\u6559\u6388\u3001\u701a\u6d77\u57fa\u56e0\u8463\u4e8b\u957f\u8d3a\u5efa\u594e\u526f\u6559\u6388\u5728\u300a\u7b2c\u4e09\u4ee3\u6d4b\u5e8f\u4e0e\u4e34\u5e8a\u5e94\u7528\u300b\u62a5\u544a\u4e2d\u5411\u5927\u5bb6\u7cfb\u7edf\u7684\u4ecb\u7ecd\u4e86\u7b2c\u4e09\u4ee3\u6d4b\u5e8f\u6280\u672f\u7684\u539f\u7406\u3001\u6027\u80fd\u4ee5\u53ca\u4e34\u5e8a\u548c\u79d1\u7814\u5e94\u7528\u73b0\u72b6\u548c\u65b9\u5411\u3002\u5185\u5bb9\u6458\u8981\u5982\u4e0b\uff1a<\/div>\n<div>1\uff09\u4e09\u4ee3\u6d4b\u5e8f\u4e0e\u4e8c\u4ee3\u6d4b\u5e8f\u76f8\u6bd4\uff0c\u5177\u6709\u4ee5\u4e0b\u7279\u70b9\uff1a\u8d85\u9ad8\u7075\u654f\u5ea6\u3001\u76f4\u63a5\u68c0\u6d4bDNA\u5355\u5206\u5b50\u3001\u65e0\u9700PCR\u6269\u589e\u3001\u65e0GC\u504f\u597d\u3001\u66f4\u591a\u5e94\u7528\u62d3\u5c55\u7b49\u3002<\/div>\n<div>2\uff09\u701a\u6d77\u57fa\u56e0\u4e09\u4ee3\u6d4b\u5e8f\u4eea\u4e09\u5927\u6838\u5fc3\u6280\u672f\uff1a \u7269\u7406\u65b9\u9762\uff0cTIRF\u663e\u5fae\u6210\u50cf\uff08\u5355\u5206\u5b50\u5168\u5185\u53cd\u5c04\u663e\u5fae\u6210\u50cf\u6280\u672f\uff09\uff1b \u5316\u5b66\u65b9\u9762\uff0c\u7ec8\u6b62\u78b1\u57fa\u3001\u8367\u5149\u6807\u8bb0\u6838\u82f7\u9178\uff0c\u63d0\u4f9b\u66f4\u9ad8\u4fdd\u771f\u5ea6\u548c\u53cd\u5e94\u6548\u7387\uff1b \u751f\u7269\u65b9\u9762\uff0c\u5355\u5206\u5b50\u78b1\u57fa\u8bc6\u522b\u3002<\/div>\n<div>3\uff09\u4e09\u4ee3\u6d4b\u5e8f\u6280\u672f\u5e94\u7528\u4e34\u5e8a\u7684\u4f18\u52bf\u5305\u62ec\uff1a\u66f4\u4f4e\u6210\u672c\uff08\u9884\u8ba12020\u5e7499\u7f8e\u5143\uff0c\u5b9e\u9a8c\u5ba4\u5efa\u8bbe\u6210\u672c\u4e0b\u964d\u3001\u8bd5\u5242\u6d88\u8017\u548c\u68c0\u6d4b\u64cd\u4f5c\u4eba\u5458\u4eba\u529b\u6d88\u8017\u4e0b\u964d\uff09\u3001\u66f4\u77ed\u5468\u671f\uff08\u6d41\u7a0b\u753119\u6b65\u51cf\u5c11\u4e3a10\u6b65\uff0c\u53ef\u7f29\u77ed\u81f31~2\u5929\uff09\u3001\u66f4\u9ad8\u7075\u654f\u5ea6\u548c\u66f4\u5f3a\u7279\u5f02\u6027\u7b49\u3002<\/div>\n<div>4\uff09\u4e09\u4ee3\u6d4b\u5e8f\u4eea\u7684\u4e34\u5e8a\u5e94\u7528\uff1aNIPT\u5e94\u7528\u3001PGS\u5e94\u7528\uff08\u65e0\u9700\u5168\u57fa\u56e0\u7ec4\u6269\u589e\uff09\u3001\u77f3\u8721\u5305\u57cb\u80bf\u7624\u7ec4\u7ec7\u6d4b\u5e8f\u3001\u75c5\u539f\u5fae\u751f\u7269\u68c0\u6d4b\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDtjXsEYibX7SY8zvu0kuWI9icj0f9syqVic9VrEtz11rPcFRgPOv9ZWQLefPr7xOgE71tS4xy3yiaKNQ.jpeg\" alt=\"RmFicvQBAkgDtjXsEYibX7SY8zvu0kuWI9icj0f9syqVic9VrEtz11rPcFRgPOv9ZWQLefPr7xOgE71tS4xy3yiaKNQ\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u5317\u4eac\u57fa\u56e0\u7ec4\u7814\u7a76\u6240\u65b9\u5411\u4e1c\u6559\u6388<\/div>\n<div>\u4e2d\u56fd\u79d1\u5b66\u9662\u5317\u4eac\u57fa\u56e0\u7ec4\u7814\u7a76\u6240\u65b9\u5411\u4e1c\u6559\u6388\u505a\u4e86\u300a\u57fa\u56e0\u7ec4\u5927\u6570\u636e\u4e0e\u57fa\u56e0\u6d4b\u5e8f\u4e34\u5e8a\u5e94\u7528\u300b\u7684\u62a5\u544a\uff0c\u4ecb\u7ecd\u4e86\u5927\u6570\u636e\u65f6\u4ee3\u57fa\u56e0\u68c0\u6d4b\u4e0e\u7cbe\u51c6\u533b\u7597\u5b9e\u8df5\u7684\u7ed3\u5408\u3002\u5185\u5bb9\u6458\u8981\u5982\u4e0b\uff1a<\/div>\n<div>1\uff09\u57fa\u56e0\u68c0\u6d4b\u6280\u672f\u662f\u201c\u5065\u5eb7\u4e2d\u56fd\u201d\u6218\u7565\u7684\u91cd\u8981\u5185\u5bb9\uff1b2015\u5e74\u9881\u5e03\u7684\u65b0\u578b\u5065\u5eb7\u6280\u672f\u60e0\u6c11\u5de5\u7a0b\u91cd\u70b9\u652f\u6301\u201c\u57fa\u56e0\u68c0\u6d4b\u6280\u672f\u5e94\u7528\u793a\u8303\u4e2d\u5fc3\u201d\uff1b\u201c\u52a0\u901f\u63a8\u52a8\u57fa\u56e0\u7ec4\u5b66\u7b49\u751f\u7269\u6280\u672f\u5927\u89c4\u6a21\u5e94\u7528\u201d\u4f4d\u5217\u201c\u5341\u4e09\u4e94\u201d\u8ba1\u5212\u5b9e\u65bd\u7684100\u4e2a\u91cd\u5927\u5de5\u7a0b\u53ca\u9879\u76ee\u4e4b\u4e2d 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