\n![\"RmFicvQBAkgCuC54K47siaoibvbClYbpoQdmoEA7Yo9T0l4l5c9wsK8DWv13zXvBYojNDUX4HpbxOEe8enSicCuVVg\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCuC54K47siaoibvbClYbpoQdmoEA7Yo9T0l4l5c9wsK8DWv13zXvBYojNDUX4HpbxOEe8enSicCuVVg.gif\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n<\/div>\n
\u5173\u952e\u8bcd\/\u7ed3\u76f4\u80a0\u764c\u514d\u75ab\u56fe\u8c31 \u6587\/\u57fa\u56e0\u6167<\/div>\n
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2018\u5e7410\u670830\u65e5\u51cc\u6668\uff0c\u5317\u4eac\u5927\u5b66\u5f20\u6cfd\u6c11\u6559\u6388\u56e2\u961f\u5728\u300aNature\u300b\u53d1\u6587\uff0c\u9996\u6b21\u523b\u753b\u4e86\u6df1\u5ea6\u7ed3\u76f4\u80a0\u764cT\u7ec6\u80de\u7684\u514d\u75ab\u56fe\u8c31\uff0c\u5e76\u53d1\u73b0\u6f5c\u5728\u514d\u75ab\u6cbb\u7597\u6807\u5fd7\u7269\u3002\u8fd9\u662f\u4e00\u5e74\u591a\u6765\u56e2\u961f\u6210\u679c\u8363\u767b\u300aCell\u300b\u548c\u300aNature Medicine\u300b\u540e\u7684\u53c8\u4e00\u529b\u4f5c\uff0c\u57fa\u56e0\u6167\u72ec\u5bb6\u91c7\u8bbf\u62a5\u9053\u5185\u5bb9\u5982\u4e0b\u3002<\/div>\n
<\/div>\n
\n\n
\n![\"RmFicvQBAkgCmh7XECNpZXsjgWjlVyU7nia5UJzMbB87tLiaLmy9pJAHpsoU6cP4icBKQYkeQYibia7tR0WffzhV0QHg\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCmh7XECNpZXsjgWjlVyU7nia5UJzMbB87tLiaLmy9pJAHpsoU6cP4icBKQYkeQYibia7tR0WffzhV0QHg.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u56fe1\uff1a\u53c2\u4e0e\u8be5\u7814\u7a76\u7684\u90e8\u5206\u4eba\u5458\u5408\u5f71<\/div>\n
1\u3001\u7814\u7a76\u6982\u51b5<\/div>\n
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\u00a0<\/div>\n
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\u00a0<\/div>\n
2\u3001\u7814\u7a76\u6210\u679c<\/div>\n
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<\/figure><\/div>\n\n
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\u00a0<\/div>\n
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CD8+\u8017\u7aed\u7ec6\u80de\u5e94\u8be5\u662f\u6709\u6297\u80bf\u7624\u4f5c\u7528\u7684T\u7ec6\u80de\uff0c\u5b83\u4eec\u9ad8\u8868\u8fbe\u4e86\u5927\u91cf\u7684\u6291\u5236\u6027\u53d7\u4f53\uff0c\u5982PDCD1\u3001CTLA4\u3001HAVCR2\u7b49\uff0c\u540c\u65f6\u53c8\u8868\u8fbe\u5927\u91cf\u7684\u7ec6\u80de\u6bd2\u6027\u76f8\u5173\u57fa\u56e0\uff0c\u7279\u522b\u662fGZMB\u3001IFNG\u3002\u6b64\u5916\uff0c\u8fd8\u6709CXCL13\u57fa\u56e0\u7684\u8868\u8fbe\uff0c\u610f\u5473\u7740\u9664\u4e86\u76f4\u63a5\u7684\u6bd2\u6027\u6740\u4f24\u4f5c\u7528\u5916\uff0c\u8fd8\u53ef\u80fd\u901a\u8fc7\u4fc3\u8fdb\u80bf\u7624\u5185\u7684\u6ee4\u6ce1\u7ed3\u6784\u5f62\u6210\uff0c\u5e76\u62db\u52dfB\u7ec6\u80de\u6765\u53d1\u6325\u6297\u80bf\u7624\u4f5c\u7528\u3002CD8+\u8017\u7aed\u7ec6\u80de\u7684\u8fd9\u4e9b\u529f\u80fd\u548c\u7279\u6027\u5728\u6700\u8fd1\u7684\u5176\u4ed6\u51e0\u4e2a\u7814\u7a76\u91cc\u4e5f\u6709\u62a5\u9053\u3002T\u7ec6\u80de\u8017\u7aed\u4e5f\u662f\u4e00\u4e2a\u5bb9\u6613\u5f15\u8d77\u6df7\u6dc6\u7684\u6982\u5ff5\u3002\u6211\u4eec\u548c\u5176\u4ed6\u4e00\u4e9b\u514d\u75ab\u5b66\u5bb6\u5982John Wherry\u8ba4\u4e3a\uff0c\u6211\u4eec\u770b\u5230\u7684CD8+\u8017\u7aed\u7ec6\u80de\u5728\u201c\u5f53\u4e0b\u201d\u662f\u6709\u5f88\u9ad8\u7684\u6bd2\u6027\u57fa\u56e0\u8868\u8fbe\u3001\u5448\u9ad8\u589e\u6b96\u72b6\u6001\u3002<\/div>\n
\u00a0<\/div>\n
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\u00a0<\/div>\n
\u80bf\u7624\u91cc\u6709\u4e24\u7fa4\u9ad8\u8868\u8fbeIFNG\u7684CD4+T\u7ec6\u80de\uff0c\u5373\u7c7bTh1\u7ec6\u80de\uff0c\u8fd9\u4e24\u7fa4\u7ec6\u80de\uff08\u5373CD4-C07-GZMK\u548cCD4-C09-CXCL13\uff09\u95f4\u6709\u5173\u952e\u8f6c\u5f55\u56e0\u5b50\u7684\u5dee\u5f02\u8868\u8fbe\uff0c\u5305\u62ecEOMES\u3001RUNX3\uff0c\u7279\u522b\u662fBHLHE40\u3002\u5176\u4e2d\u9ad8\u8868\u8fbeBHLHE40\u7684\u7c7bTh1\u7ec6\u80de\u4e5f\u8868\u8fbe\u4e86CXCL13\u548cIGFLR1\u3002\u540e\u8005\u6211\u4eec\u901a\u8fc7\u529f\u80fd\u5b9e\u9a8c\uff0c\u8ba4\u4e3a\u5177\u6709T\u7ec6\u80de\u5171\u6fc0\u6d3b\u53d7\u4f53\u6027\u8d28\u3002\u8fd9\u4e24\u7fa4\u7c7bTh1\u7ec6\u80de\u4e4b\u95f4\u4e5f\u6709\u8f83\u9ad8\u7684\u72b6\u6001\u8f6c\u79fb\u6307\u6570\uff0c\u610f\u5473\u7740\u5b83\u4eec\u4e4b\u95f4\u5177\u6709\u5206\u5316\u5173\u7cfb\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u76f8\u6bd4MSS\u75c5\u4eba\uff0c\u53ea\u6709CXCL13\u9ad8\u8868\u8fbe\u4e14BHLHE40\u9ad8\u8868\u8fbe\u7684\u8fd9\u7fa4\u7c7bTh1\u7ec6\u80de\u5728MSI\u7ed3\u76f4\u80a0\u764c\u91cc\u6709\u66f4\u591a\u7684\u5bcc\u96c6\uff0c\u56e0\u6b64\u8fd9\u7fa4\u7c7bTh1\u7ec6\u80de\u53ef\u80fd\u4f7f\u5f97MSI\u7ed3\u76f4\u80a0\u764c\u6709\u66f4\u597d\u7684\u514d\u75ab\u6cbb\u7597\u54cd\u5e94\u3002<\/div>\n
\u5176\u4ed6\u7c7b\u7684T\u7ec6\u80de\u8fd8\u5305\u62ec\u4ece\u521d\u59cbT\u7ec6\u80de\u5230\u4e0d\u540c\u5206\u5316\u7ec8\u7aef\u7684T\u7ec6\u80de\uff0c\u5982\u5bcc\u96c6\u5728\u6b63\u5e38\u80a0\u7c98\u819c\u91cc\u7684Tfh\u3001\u5185\u76aeT\u6dcb\u5df4\u7ec6\u80de(IEL)\u7b49\u3002<\/div>\n\n
\n![\"RmFicvQBAkgCmh7XECNpZXsjgWjlVyU7nhkjoNvDm37ibTneuz3T0FYTJtT5icBOwThuZRjmWZib67bOoGCMnmAdXg\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCmh7XECNpZXsjgWjlVyU7nhkjoNvDm37ibTneuz3T0FYTJtT5icBOwThuZRjmWZib67bOoGCMnmAdXg.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u56fe3\uff1a\u7ed3\u76f4\u80a0\u764c\u60a3\u8005T\u7ec6\u80de\u4e3b\u8981\u7c7b\u7fa4\u53ca\u5176\u7279\u5f81<\/p>\n
3\u3001\u4ea7\u3001\u5b66\u3001\u7814\u3001\u533b\u5408\u4f5c<\/p>\n
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\u00a0<\/div>\n
4\u3001\u6280\u672f\u521b\u65b0\u4e0e\u7a81\u7834<\/div>\n
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\u00a0<\/div>\n
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STARTRAC\u7684\u6307\u6570\u5bf9\u7ec6\u80de\u6570\u6ca1\u6709\u660e\u786e\u7684\u8981\u6c42\u3002\u5f53\u7136\u5982\u679c\u6709\u66f4\u591a\u7684\u7ec6\u80de\uff0c\u53ef\u4ee5\u5f97\u5230\u66f4\u51c6\u786e\u7684\u5b9a\u91cf\u5206\u6790\u7ed3\u679c\u548c\u7ed3\u8bba\u3002<\/div>\n\n
\n![\"RmFicvQBAkgCmh7XECNpZXsjgWjlVyU7nISYRYBe5Gia2r6MvskJw2FibyP1qSO2zyTDuiazledsWOBrAI9N4seiasg\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCmh7XECNpZXsjgWjlVyU7nISYRYBe5Gia2r6MvskJw2FibyP1qSO2zyTDuiazledsWOBrAI9N4seiasg.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u56fe4\uff1aSTARTRAC\u56fe\u793a<\/div>\n
5\u3001\u809d\u764c\u3001\u80ba\u764c\u4e0e\u7ed3\u76f4\u80a0\u764c\u7814\u7a76\u7684\u5dee\u5f02<\/div>\n
\u00b7\u00a0\u5927\u91cfT\u7ec6\u80de\u6df1\u5ea6\u5355\u7ec6\u80de\u6d4b\u5e8f<\/div>\n
\u00b7\u00a0\u6bd4\u8f83MSI\u548cMSS\u7c7b\u578b\u7684\u7ed3\u76f4\u80a0\u764c<\/div>\n
\u00b7\u00a0\u4e0d\u540c\u7c7b\u80bf\u7624\u6d78\u6da6\u7684T\u7ec6\u80de\u6709\u5f88\u5927\u5dee\u5f02<\/div>\n
\u3010\u57fa\u56e0\u6167\u3011\u76f8\u6bd4\u6b64\u524d\u7814\u7a76\u7684\u80ba\u764c\u548c\u809d\u764c\uff08\u8be6\u60c5<\/a>\uff09\uff0c\u7ed3\u76f4\u80a0\u764c\u7684T\u7ec6\u80de\u5355\u7ec6\u80de\u514d\u75ab\u56fe\u8c31\u7684\u7814\u7a76\u6709\u54ea\u4e9b\u4e0d\u540c\u548c\u501f\u9274\u4e4b\u5904\u5462\uff1f<\/div>\n
\u3010\u5f20\u56ed\u56ed\u3011\uff08\u5171\u540c\u4e00\u4f5c\uff09\u8fd9\u4e09\u4e2a\u7814\u7a76\u5728\u603b\u4f53\u601d\u8def\u4e0a\u91c7\u7528\u4e86\u76f8\u540c\u7684\u7b56\u7565\uff0c\u5373\u5bf9\u764c\u75c7\u60a3\u8005\u7684\u5927\u91cfT\u7ec6\u80de\u8fdb\u884c\u6df1\u5ea6\u5355\u7ec6\u80de\u6d4b\u5e8f\uff0c\u7136\u540e\u6574\u5408\u57fa\u56e0\u8868\u8fbe\u548cTCR\u7684\u4fe1\u606f\u8fdb\u884c\u6df1\u5165\u5206\u6790\u3002\u76f8\u6bd4\u800c\u8a00\uff0c\u7ed3\u76f4\u80a0\u764cT\u7ec6\u80de\u7684\u7814\u7a76\u6709\u4e0d\u540c\u7684\u7279\u70b9\u3002<\/div>\n
\u9996\u5148\uff0c\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a(MSI)\u7684\u7ed3\u76f4\u80a0\u764c\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u54cd\u5e94\u663e\u8457\u9ad8\u4e8e\u5fae\u536b\u661f\u7a33\u5b9a(MSS)\u7684\u7ed3\u76f4\u80a0\u764c\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u5728\u6700\u521d\u9879\u76ee\u8bbe\u8ba1\u7684\u65f6\u5019\u5c31\u51b3\u5b9a\u6536\u96c6\u8fd9\u4e24\u79cd\u4e0d\u540c\u7c7b\u578b\u7684\u7ed3\u76f4\u80a0\u764c\u3002MSI\u7684\u7ed3\u76f4\u80a0\u764c\u5728\u7ed3\u76f4\u80a0\u764c\u4e2d\u7684\u6bd4\u4f8b\u6bd4\u8f83\u5c11\uff0c\u636e\u7edf\u8ba1\u4e0d\u8d85\u8fc715%\u3002\u6211\u4eec\u6700\u7ec8\u603b\u5171\u6536\u96c6\u52304\u4e2a\u5c5e\u4e8eMSI\u7c7b\u578b\u7684\u7ed3\u76f4\u80a0\u764c\u3002<\/div>\n
\u00a0<\/div>\n
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\u6700\u540e\uff0c\u4e09\u4e2a\u7814\u7a76\u7ed9\u6211\u4eec\u542f\u793a\uff0c\u9879\u76ee\u8bbe\u8ba1\u7684\u65f6\u5019\u9700\u8981\u9488\u5bf9\u6709\u91cd\u5927\u610f\u4e49\u7684\u4e34\u5e8a\u95ee\u9898\uff0c\u5982\u7ed3\u76f4\u80a0\u764cT\u7ec6\u80de\u7684\u7814\u7a76\u4e2d\uff0c\u6bd4\u8f83MSI\u548cMSS\u7c7b\u578b\u7684\u7ed3\u76f4\u80a0\u764c\u5c31\u662f\u4e00\u4e2a\u5f88\u597d\u7684\u4f8b\u5b50\uff0c\u8fd9\u4e5f\u662f\u6211\u4eec\u89c9\u5f97\u53ef\u4ee5\u501f\u9274\u7684\u5730\u65b9\u4e4b\u4e00\u3002\u6bd4\u5982\uff0c\u5f00\u5c55\u65b0\u7684\u7814\u7a76\u8bfe\u9898\u53ef\u4ee5\u8003\u8651\u6bd4\u8f83\u60a3\u8005\u5728\u514d\u75ab\u6cbb\u7597\u524d\u3001\u514d\u75ab\u6cbb\u7597\u540e\u7684\u514d\u75ab\u7ec6\u80de\u3002<\/div>\n\n
\n![\"RmFicvQBAkgCmh7XECNpZXsjgWjlVyU7nNkb4P04HT0iaP09R1J5jzvGTIpRdUFkwYUAXnicUp5xZnZgSaZicgoNdg\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCmh7XECNpZXsjgWjlVyU7nNkb4P04HT0iaP09R1J5jzvGTIpRdUFkwYUAXnicUp5xZnZgSaZicgoNdg.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u56fe5\uff1a\u4e09\u79cd\u80bf\u7624\u7684T\u7ec6\u80de\u7ec4\u6210\u5b58\u5728\u660e\u663e\u5dee\u5f02<\/div>\n
6\u3001\u53d1\u73b0\u6f5c\u5728\u514d\u75ab\u6cbb\u7597\u6807\u5fd7\u7269<\/div>\n
\u00b7\u00a0CXCL13+BHLHE40+\u7c7bTH1\u7ec6\u80de<\/div>\n
\u00b7\u00a0\u9700\u4e34\u5e8a\u6570\u636e\u548c\u57fa\u7840\u7814\u7a76\u8fdb\u4e00\u6b65\u9a8c\u8bc1<\/div>\n
\u3010\u57fa\u56e0\u6167\u3011\u6b64\u6b21\u7814\u7a76\u53d1\u73b0\uff0cMSI\u764c\u75c7\u60a3\u8005\u4e2d\u5982\u679cCXCL13+BHLHE40+\u7c7bTH1\u7ec6\u80de\u5bcc\u96c6\uff0c\u53ef\u80fd\u8fd9\u4e9b\u60a3\u8005\u4f1a\u5bf9\u514d\u75ab\u7597\u6cd5\u4ea7\u751f\u79ef\u6781\u54cd\u5e94\uff0c\u8fd9\u662f\u5426\u5c5e\u4e8e\u65b0\u53d1\u73b0\u7684\u6807\u5fd7\u7269\uff0c\u5c06\u5bf9\u764c\u75c7\u60a3\u8005\u6cbb\u7597\u4ea7\u751f\u600e\u6837\u7684\u5e2e\u52a9\uff1f\u672a\u6765\u5982\u679c\u843d\u5730\u4e34\u5e8a\uff0c\u8fd8\u9700\u8981\u8fdb\u884c\u54ea\u4e9b\u5de5\u4f5c\u5462\uff1f<\/div>\n
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\u00a0<\/div>\n
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<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u56fe6\uff1a\u6bd4\u8f83MSI\u548cMSS\u7ed3\u76f4\u80a0\u764c<\/div>\n
7\u3001\u57fa\u7840\u7814\u7a76\u4e3a\u514d\u75ab\u7597\u6cd5\u5e26\u6765\u6307\u5bfc<\/div>\n
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\u00a0<\/div>\n
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\u00a0<\/div>\n
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