{"id":9355,"date":"2018-11-16T17:34:16","date_gmt":"2018-11-16T09:34:16","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&mid=100008227&idx=1&sn=052d8af20cdd1d86d7a6ed8ddb6ff7cb&chksm=6b7153945c06da8224801cb973d7f3d76e9ac80ec636ba6458ccb22c5a5476112bd38b6106f6#rd"},"modified":"2026-04-02T16:08:42","modified_gmt":"2026-04-02T08:08:42","slug":"5055100","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2018\/11\/16\/5055100\/","title":{"rendered":"GeneMail\u5468\u62a5 | Nebula Genomics\u63a8\u51fa\u514d\u8d39\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u9879\u76ee\uff1bcfDNA\u7532\u57fa\u5316\u68c0\u6d4b\u9769\u65b0\u764c\u75c7\u6db2\u4f53\u6d3b\u68c0"},"content":{"rendered":"

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\"RmFicvQBAkgCuC54K47siaoibvbClYbpoQdmoEA7Yo9T0l4l5c9wsK8DWv13zXvBYojNDUX4HpbxOEe8enSicCuVVg\"\/<\/figure><\/div>\n\n<\/div>\n
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\u6587\/\u57fa\u56e0\u6167<\/div>\n
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\u57fa\u56e0\u6167\u672c\u5468\u770b\u70b9\uff1aNebula Genomics\u63a8\u51fa\u514d\u8d39\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u9879\u76ee\uff1bcfDNA\u7532\u57fa\u5316\u68c0\u6d4b\u9769\u65b0\u764c\u75c7\u6db2\u4f53\u6d3b\u68c0\uff1b7\u4e07\u4e2a\u5355\u7ec6\u80de\u6d4b\u5e8f\u7ed8\u5236\u4eba\u7c7b\u598a\u5a20\u65e9\u671f\u80ce\u76d8\u56fe\u8c31\uff1bmRNA\u7597\u6cd5\u65b0\u9510Moderna\u62dfIPO\u52df\u8d445\u4ebf\u7f8e\u5143\uff1bGoogle\u65b0\u7ec4\u5efaGoogle Health\u53d1\u529b\u667a\u6167\u533b\u7597\uff1b\u66f4\u591a\u672c\u5468\u8d44\u8baf\u8be6\u89c1\u4e0b\u6587\u3002<\/div>\n
\u00a0<\/div>\n
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\"?wx_fmt=jpeg\"\/<\/figure><\/div>\n\n
\u3010\u56fe\u6587\u6545\u4e8b\u3011\u672c\u5468\uff0c\u6765\u81ea\u52a0\u5dde\u5927\u5b66\u6234\u7ef4\u65af\u5206\u6821\u7684\u79d1\u5b66\u5bb6\u53d1\u73b0\u80a5\u80d6\u867d\u662f\u4e00\u5927\u60a3\u764c\u98ce\u9669\u56e0\u7d20\uff0c\u4f46\u540c\u65f6\u80a5\u80d6\u60a3\u8005\u5728\u63a5\u53d7\u514d\u75ab\u6cbb\u7597\u65f6T\u7ec6\u80de\u5bf9PD-1\u6291\u5236\u5242\u66f4\u52a0\u654f\u611f\uff0c\u6297\u80bf\u7624\u6548\u679c\u66f4\u597d\u3002<\/div>\n
\u00a0<\/div>\n
\u672c\u5468\u5934\u6761<\/div>\n
\u25bc Nebula Genomics\u63a8\u51fa\u514d\u8d39\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u9879\u76ee<\/div>\n\n
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\"640?wx_fmt=jpeg\"\/<\/figure><\/div>\n\n
11\u670816\u65e5\uff0c\u7531\u8457\u540d\u9057\u4f20\u5b66\u5bb6George Church\u521b\u7acb\u7684\u533a\u5757\u94fe\u57fa\u56e0\u7ec4\u5b66\u65b0\u9510Nebula Genomics\u5ba3\u5e03\uff0c\u5c06\u901a\u8fc7\u5176\u65b0\u5e73\u53f0nebula.org\u514d\u8d39\u5411\u516c\u4f17\u63d0\u4f9b\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u670d\u52a1\u3002\u7528\u6237\u9700\u8981\u56de\u7b54\u4e00\u4e9b\u4f53\u5f81\u5065\u5eb7\u7b49\u76f8\u5173\u95ee\u9898\uff0c\u662f\u5426\u66fe\u6709\u764c\u75c7\u3001\u5fc3\u8840\u7ba1\u75c5\u3001\u7cd6\u5c3f\u75c5\u7b49\u75be\u75c5\u53f2\uff0c\u670d\u7528\u8fc7\u54ea\u4e9b\u836f\u7269\uff0c\u662f\u5426\u5438\u70df\u7b49\u76f8\u5173\u95ee\u9898\uff0c\u8fdb\u800c\u83b7\u5f97\u514d\u8d39\u6d4b\u5e8f\u7684\u79ef\u5206\u3002\u56de\u7b54\u95ee\u9898\u83b7\u5f97\u8db3\u591f\u7684\u79ef\u5206\u540e\uff0c\u6216\u79f0\u4e4b\u4e3a\u201ctokens\u201d\uff0c\u5c06\u53ef\u4ee5\u514d\u8d39\u8fdb\u884cDNA\u6d4b\u5e8f\uff0c\u5e76\u4e14\u514d\u8d39\u68c0\u6d4b\u5c06\u5177\u670930X\u7684\u8986\u76d6\u7387\u3002<\/div>\n
\u00a0<\/div>\n
\u4e3a\u4e86\u4ece\u6d88\u8d39\u7ea7\u57fa\u56e0\u68c0\u6d4b\u9886\u57df\u8131\u9896\u800c\u51fa\uff0c\u539f\u672c\u81ea\u5e26\u5149\u73af\u7684Nebula\u625b\u8d77\u514d\u8d39\u57fa\u56e0\u68c0\u6d4b\u5927\u65d7\uff0c\u5438\u5f15\u5927\u91cf\u7528\u6237\u5feb\u901f\u79ef\u7d2f\u6837\u672c\uff0c\u5176\u5546\u4e1a\u6a21\u5f0f\u662f\u5236\u836f\u4f01\u4e1a\u548c\u7814\u7a76\u673a\u6784\u652f\u4ed8\u6d4b\u5e8f\u6210\u672c\uff0c\u4f5c\u4e3a\u4ea4\u6362\uff0c\u4ed6\u4eec\u4e5f\u4f1a\u5f97\u5230\u7528\u6237\u7684\u4e00\u4e9b\u6570\u636e\u3002\u5904\u4e8e\u4fdd\u62a4\u7528\u6237\u9690\u79c1\u7684\u8003\u8651\uff0cNebula\u8fd8\u5f00\u53d1\u4e86\u57fa\u4e8e\u533a\u5757\u94fe\u7684\u4fe1\u606f\u4fdd\u62a4\u6280\u672f\uff0c\u7528\u6237\u4eab\u6709\u5176\u4e2a\u4eba\u57fa\u56e0\u7ec4\u6570\u636e\u7684\u6240\u6709\u6743\u3002\u4ece\u4fdd\u969c\u7528\u6237\u7684\u57fa\u56e0\u4fe1\u606f\u7684\u5b89\u5168\u4f7f\u7528\u548c\u5206\u4eab\u5c42\u9762\u51fa\u53d1\uff0cNebula\u91c7\u53d6\u98a0\u8986\u6027\u7684\u5546\u4e1a\u51b3\u7b56\uff0c\u5c06\u9010\u6b65\u6253\u9020\u4e00\u4e2a\u57fa\u56e0\u7ec4\u548c\u5065\u5eb7\u6570\u636e\u5206\u4eab\u7684\u5e73\u53f0\u3002\u672a\u6765\u53ef\u4ee5\u9884\u89c1\u5230\uff0c\u57fa\u56e0\u6d4b\u5e8f\u6210\u672c\u8fdb\u4e00\u6b65\u964d\u4f4e\uff0c\u6709\u671b\u83b7\u53d6\u66f4\u591a\u6f5c\u5728\u7528\u6237\u3002<\/div>\n
\u00a0<\/div>\n
\u653f\u7b56<\/div>\n
\u25bc \u5173\u952e\u8bcd\uff1a\u652f\u6301\u65b0\u5174\u4ea7\u4e1a<\/div>\n
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11\u670813\u65e5\uff0c\u6df1\u5733\u5e02\u4eba\u6c11\u653f\u5e9c\u53d1\u5e03\u300a\u6df1\u5733\u5e02\u5173\u4e8e\u8fdb\u4e00\u6b65\u52a0\u5feb\u53d1\u5c55\u6218\u7565\u6027\u65b0\u5174\u4ea7\u4e1a\u7684\u5b9e\u65bd\u65b9\u6848\u300b\uff0c\u660e\u786e\u63d0\u51fa\u5e03\u5c40\u8111\u79d1\u5b66\u4e0e\u7c7b\u8111\u7814\u7a76\u3001\u7cbe\u51c6\u533b\u5b66\u6210\u50cf\u3001\u5408\u6210\u751f\u7269\u5b66\u3001\u4eba\u7c7b\u589e\u5f3a\u7b49\u91cd\u5927\u524d\u6cbf\u9886\u57df\uff0c\u5b9e\u73b0\u57fa\u56e0\u68c0\u6d4b\u548c\u4e2a\u4f53\u5316\u6cbb\u7597\u6280\u672f\u9886\u57df\u91cd\u5927\u7a81\u7834\uff0c\u642d\u5efa\u751f\u547d\u5065\u5eb7\u5927\u6570\u636e\u5e73\u53f0\uff0c\u6253\u9020\u56fd\u9645\u9886\u5148\u7684\u7cbe\u51c6\u533b\u7597\u793a\u8303\u533a\u3002<\/div>\n
\u00a0<\/div>\n
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\u25bc \u5173\u952e\u8bcd\uff1a\u764c\u75c7\u65e9\u68c0<\/div>\n
Nature\uff1acfDNA\u7532\u57fa\u5316\u68c0\u6d4b\u9769\u65b0\u764c\u75c7\u6db2\u4f53\u6d3b\u68c0<\/div>\n
11\u670815\u65e5\uff0c\u300aNature\u300b\u520a\u6587\uff0c\u52a0\u62ff\u5927Princess Margaret\u764c\u75c7\u4e2d\u5fc3\u7684\u79d1\u5b66\u5bb6\u53d1\u73b0\uff0c\u901a\u8fc7\u68c0\u6d4b\u5206\u6790\u8840\u6db2\u4e2d\u6e38\u79bbDNA\uff08cfDNA\uff09\u7684\u7532\u57fa\u5316\u7279\u5f81\uff0c\u6709\u52a9\u53d1\u73b0\u65e9\u671f\u764c\u75c7\uff0c\u540c\u65f6\u5229\u7528\u673a\u5668\u5b66\u4e60\u6280\u672f\uff0c\u9ad8\u51c6\u786e\u7387\u533a\u5206\u764c\u75c7\u7c7b\u578b\u3002<\/div>\n
\u00a0<\/div>\n
\u9776\u5411\u964d\u7cd6\u9776\u70b9SGLT2\u52a9\u529b\u80ba\u817a\u764c\u65e9\u68c0<\/div>\n
11\u670815\u65e5\uff0c\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\u7684\u79d1\u5b66\u5bb6\u53d1\u73b0\u80ba\u817a\u764c\u65e9\u68c0\u65b0\u9776\u70b9SGLT2\uff0c\u5e76\u53d1\u8868\u5728\u300aScience Translational Medicine\u300b\uff0cSGLT2\u4f1a\u5728\u764c\u524d\u75c5\u53d8\u3001\u764c\u75c7\u65e9\u671f\u548c\u9ad8\u5ea6\u5206\u5316\u7684\u80ba\u817a\u764c\u4e2d\u8868\u8fbe\uff0c\u5229\u7528FDA\u6279\u51c6\u7684\u6291\u5236\u5242gliflozins\u9776\u5411SGLT2\uff0c\u6781\u5927\u5730\u51cf\u7f13\u80bf\u7624\u751f\u957f\u3001\u5ef6\u957f\u5c0f\u9f20\u751f\u5b58\u671f\u3002\u7ed3\u5408\u65b0\u578b\u663e\u5f71\u5242\uff0c\u53ef\u4ee5\u65e9\u671f\u68c0\u6d4b\u5e76\u53ca\u65e9\u63a7\u5236\u3002<\/div>\n
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7\u4e07\u4e2a\u5355\u7ec6\u80de\u6d4b\u5e8f\u7ed8\u5236\u4eba\u7c7b\u598a\u5a20\u65e9\u671f\u80ce\u76d8\u56fe\u8c31<\/div>\n
11\u670815\u65e5\uff0c\u82f1\u56fd\u5251\u6865\u6851\u683c\u7814\u7a76\u6240\u79d1\u5b66\u5bb6\u5728\u300aNature\u300b\u520a\u6587\uff0c\u6839\u636e\u598a\u5a20\u65e9\u671f\u80ce\u76d8\u7ea67\u4e07\u4e2a\u7ec6\u80de\u8fdb\u884c\u5355\u7ec6\u80de\u6d4b\u5e8f\u5e76\u7ed8\u5236\u4e86\u56fe\u8c31\uff0c\u5f00\u53d1\u51fa\u65b0\u7684\u7edf\u8ba1\u5de5\u5177CellPhone\u9884\u6d4b\u6f5c\u5728\u7ec6\u80de\u95f4\u4e92\u4f5c\uff0c\u4e3a\u7406\u89e3\u4eba\u7c7b\u598a\u5a20\u65e9\u671f\u63d0\u4f9b\u4e86\u91cd\u8981\u7814\u7a76\u4fe1\u606f\u3002<\/div>\n
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PNAS\uff1a\u513f\u7ae5\u8425\u517b\u4e0d\u826f\u6539\u53d8\u7532\u57fa\u5316\u72b6\u6001<\/div>\n
11\u670813\u65e5\uff0c\u5f17\u5409\u5c3c\u4e9a\u5927\u5b66\u9886\u5bfc\u7684\u56fd\u9645\u7814\u7a76\u5c0f\u7ec4\u5bf9\u5b5f\u52a0\u62c9\u56fd\u8fbe\u5361\u8d2b\u6c11\u533a\u513f\u7ae5\u7684\u7532\u57fa\u5316\u6a21\u5f0f\u8fdb\u884c\u7814\u7a76\u540e\u53d1\u73b0\uff0c\u53d1\u80b2\u4e0d\u826f\u7684\u513f\u7ae5\u5b58\u5728\u7ec4\u86cb\u767dH3\u8d56\u6c28\u91784\u7532\u57fa\u5316\uff08H3K4me3\uff09\u7684\u91cd\u6392\uff0c\u4e14LRP1\u57fa\u56e0\u5728\u53d1\u80b2\u8fdf\u7f13\u7684\u513f\u7ae5\u4e2d\u8868\u8fbe\u964d\u4f4e\uff0c\u53ef\u80fd\u5f71\u54cd\u4e86\u514d\u75ab\u53cd\u5e94\u548c\u8102\u8d28\u4ee3\u8c22\u3002<\/div>\n
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11\u670815\u65e5\uff0c\u8fbe\u5b89\u57fa\u56e0\u5ba3\u5e03\u5176\u5168\u8d44\u5b50\u516c\u53f8\u8fbe\u5b89\u79d1\u6280\u5c06\u6536\u8d2d\u5e7f\u5dde\u57fa\u91d1\u6240\u6301\u6709\u7684\u8fbe\u5b89\u5065\u5eb7\u4ea7\u4e1a\u57fa\u91d139.60%\u80a1\u6743\uff0c\u4ea4\u6613\u4ef7\u683c1.20\u4ebf\u5143\uff0c\u5065\u5eb7\u4ea7\u4e1a\u57fa\u91d1\u5c06\u6210\u4e3a\u8fbe\u5b89\u57fa\u56e0\u7684\u5168\u8d44\u57fa\u91d1\u3002\u8fbe\u5b89\u5065\u5eb7\u4ea7\u4e1a\u57fa\u91d1\u7531\u8fbe\u5b89\u57fa\u56e0\u3001\u8fbe\u5b89\u79d1\u6280\u4e0e\u5e7f\u5dde\u57fa\u91d1\u4e09\u65b9\u57282015\u5e74\u5171\u540c\u51fa\u8d44\u8bbe\u7acb\u3002<\/div>\n
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Google Health\u6210\u7acb\uff0c\u5e76\u5165DeepMind\u5065\u5eb7\u4e1a\u52a1<\/div>\n
11\u670814\u65e5\uff0cGoogle\u5ba3\u5e03\u65b0\u7ec4\u5efaGoogle Health(\u8c37\u6b4c\u5065\u5eb7\uff09\uff0c\u5e76\u5c06Alphabet\u65d7\u4e0bDeepMind\u7684\u5065\u5eb7\u4e1a\u52a1\u7eb3\u5165\u5176\u4e2d\uff0c\u5c06\u501f\u52a9\u5176\u5f3a\u52b2\u7684AI\u80cc\u666f\u548c\u80fd\u529b\u653b\u514b\u533b\u7597\u96be\u9898\uff0cDeepMind\u5176\u4ed6\u4e1a\u52a1\u5c06\u7ee7\u7eed\u72ec\u7acb\u8fd0\u8425\u3002<\/div>\n
\u00a0<\/div>\n
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11\u670810\u65e5\uff0c\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u4e2d\u5fc3\uff08NCI\uff09\u5ba3\u5e03\u5c06\u5411\u6210\u4eba\u548c\u513f\u7ae5\u8111\u764c\u7684\u4e24\u4e2a\u6d4b\u5e8f\u9879\u76ee\u63d0\u4f9b400\u4e07\u7f8e\u5143\u8d44\u91d1\u7684\u8d44\u52a9\uff0c\u4e24\u4e2a\u9879\u76ee\u5206\u522b\u4e3aGBM CARE\u548cProject HOPE\uff0c\u901a\u8fc7\u5355\u7ec6\u80de\u6d4b\u5e8f\u6280\u672f\u7814\u7a76\u80bf\u7624\u57fa\u56e0\u7ec4\u5b66\u4e0e\u5fae\u73af\u5883\uff0c\u52a0\u6df1\u7406\u89e3\u590d\u6742\u7684\u8111\u764c\u3002<\/div>\n
\u00a0<\/div>\n
\u25bc \u5173\u952e\u8bcd\uff1a\u4e13\u5229\u4fb5\u6743<\/div>\n
Bio-Rad\u5728\u4e0e10x Genomics\u4e13\u5229\u4fb5\u6743\u8bc9\u8bbc\u6848\u4e2d\u83b7\u8d542390\u4e07\u7f8e\u5143<\/div>\n
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