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\"RmFicvQBAkgBx1UtZUYW4BgSfiaibHgOrLCvLU4YiawuYbbDWhesE8TQgkoqibYVnibkQibPw0j1NNyY8bGcKFmXhgKdg\"\/<\/figure><\/div>\n\n
\u5212\u91cd\u70b9\u00a0\u00a0<\/div>\n
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\u00a0<\/div>\n
01\u00a0\u8bf1\u5bfc\u5e72\u7ec6\u80de\u4ec5\u9700\u6fc0\u6d3b\u4e00\u4e2a\u57fa\u56e0<\/div>\n\n
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\"?wx_fmt=jpeg\"\/<\/figure><\/div>\n\n
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\u2022 \u8bba\u6587\u53d1\u8868\uff1a2018\u5e741\u670819\u65e5\u300aCell Stem Cell\u300b\uff0chttps:\/\/www.cell.com\/cell-stem-cell\/fulltext\/S1934-5909(17)30501-5<\/div>\n
\u62d3\u5c55\u9605\u8bfb<\/div>\n
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\u00a0<\/div>\n
02\u00a0\u975e\u4eba\u7075\u957f\u7c7b\u52a8\u7269\u7684\u514b\u9686<\/div>\n\n
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\u00a0<\/div>\n
03\u00a0\u7ed8\u5236\u4e16\u754c\u9996\u4e2a\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u56fe\u8c31<\/div>\n\n
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\"?wx_fmt=jpeg\"\/<\/figure><\/div>\n\n
\u2022\u00a0\u6280\u672f\u7a81\u7834\uff1a\u5229\u7528\u81ea\u4e3b\u5f00\u53d1\u7684Microwell-seq\u9ad8\u901a\u91cf\u5355\u7ec6\u80de\u6d4b\u5e8f\u5e73\u53f0\uff0c\u5bf9\u5c0f\u9f2040\u4f59\u4e07\u4e2a\u7ec6\u80de\u8fdb\u884c\u4e86\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u5206\u6790\uff0c\u6210\u529f\u6784\u5efa\u9996\u4e2a\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u56fe\u8c31\u3002<\/div>\n
\u2022\u00a0\u7814\u7a76\u9886\u57df\uff1a\u7ec6\u80de\u56fe\u8c31<\/div>\n
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\u2022\u00a0\u8bba\u6587\u53d1\u8868\uff1a2018\u5e742\u670823\u65e5\u300aCell\u300b\uff0chttps:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(18)30116-8<\/div>\n
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1\uff09\u76f8\u5173\u4e13\u5bb6\u8bbf\u8c08\uff1a\u5317\u4eac\u5927\u5b66\u5f20\u6cfd\u6c11\u6559\u6388\u56e2\u961f<\/a>\u00a0|\u00a0\u4e0a\u6d77\u4ea4\u5927\u65bd\u5947\u60e0\u6559\u6388<\/a><\/div>\n
2\uff09\u968f\u7740\u5355\u7ec6\u80de\u6d4b\u5e8f\u6280\u672f\u9010\u6e10\u6210\u719f\uff0c\u5173\u4e8e\u7ec6\u80de\u56fe\u8c31\u7684\u7814\u7a76\u663e\u8457\u589e\u591a\uff0c\u76ee\u524d\u5e7f\u6cdb\u5e94\u7528\u4e8e\u4eba\u7c7b\u53d1\u80b2\u7684\u7814\u7a76\u4e0e\u75be\u75c5\u673a\u7406\u7684\u53d1\u73b0\u3002\u4eba\u7c7b\u7ec6\u80de\u56fe\u8c31\u8ba1\u5212\uff08HCA\uff09\u88ab\u8a89\u4e3a\u4e0e\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\uff08HGP\uff09\u6bd4\u80a9\u7684\u5168\u7403\u6027\u79d1\u7814\u9879\u76ee\uff0c\u5df2\u4e8e\u4eca\u5e743\u6708\u4efd\u5b8c\u621025\u4e07\u53d1\u80b2\u7ec6\u80de\u6d4b\u5e8f\uff0c\u5c06\u8be6\u7ec6\u63cf\u8ff0\u4f53\u5185\u7ec6\u80de\u7684\u6570\u91cf\u3001\u7c7b\u578b\u3001\u5173\u7cfb\u7b49\u91cd\u8981\u4fe1\u606f\uff0c\u672a\u6765\u548c\u57fa\u56e0\u56fe\u8c31\u7684\u7ed3\u5408\u5c06\u5b9e\u73b0\u751f\u7269\u4fe1\u606f\u5927\u6570\u636e\u8d28\u7684\u98de\u8dc3\u3002<\/div>\n
\u00a0<\/div>\n
04\u00a04\u500d\u4f4d\u70b9\u7684\u65b0\u578bCRISPR\u526a\u5200<\/div>\n\n
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\"?wx_fmt=jpeg\"\/<\/figure><\/div>\n\n
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\u2022\u00a0\u7814\u7a76\u9886\u57df\uff1a\u57fa\u56e0\u7f16\u8f91<\/div>\n
\u2022\u00a0\u4e3b\u8981\u7814\u7a76\u56e2\u961f\uff1aDavid R. Liu\u56e2\u961f\uff08\u54c8\u4f5b\u5927\u5b66\/Broad\u7814\u7a76\u6240\uff09<\/div>\n
\u2022\u00a0\u5e94\u7528\u524d\u666f\uff1a\u57fa\u56e0\u6cbb\u7597<\/div>\n
\u2022\u00a0\u8bba\u6587\u53d1\u8868\uff1a2018\u5e742\u670828\u65e5\u300aNature\u300b\uff0chttps:\/\/www.nature.com\/articles\/nature26155<\/div>\n
\u62d3\u5c55\u9605\u8bfb<\/div>\n
David Liu\u4e0e\u5f20\u950b\u3001Jennifer Doudna\u7b49\u662f\u57fa\u56e0\u7f16\u8f91\u9886\u57df\u7684\u79d1\u7814\u5927\u725b\u3002\u8fd1\u51e0\u5e74\u4ece\u950c\u6307\u6838\u9178\u5185\u5207\u9176\uff08ZFN\uff09\u3001\u7c7b\u8f6c\u5f55\u6fc0\u6d3b\u56e0\u5b50\u6548\u5e94\u7269\u6838\u9178\u9176\uff08TALEN\uff09\u5230CRISPR\/Cas9\uff0c\u9010\u6e10\u63d0\u9ad8\u57fa\u56e0\u7f16\u8f91\u7684\u7cbe\u51c6\u5ea6\u548c\u53ef\u64cd\u4f5c\u6027\u7b49\u3002\u5176\u4e2d\uff0c\u5df2\u6709\u4e24\u9879CRISPR\u7597\u6cd5\u7533\u62a5\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4eca\u5e7410\u6708FDA\u6279\u51c6CRISPR Therapeutics\u4e0eVertex Pharmaceuticals\u5408\u4f5c\u7814\u53d1\u7684\u9488\u5bf9\u9570\u5200\u578b\u7ec6\u80de\u8d2b\u8840\u75c7\u7684\u57fa\u56e0\u7597\u6cd5\u8fdb\u5165\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\uff0c12\u6708\u521d\u5f20\u950b\u516c\u53f8\u6cbb\u7597\u7f55\u89c1\u773c\u75be\u7684\u57fa\u56e0\u7f16\u8f91\u7597\u6cd5\u4e5f\u7ecfFDA\u5ba1\u6279\u8fdb\u5165\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\uff0c\u8fd9\u624d\u662f\u57fa\u56e0\u7f16\u8f91\u771f\u6b63\u9020\u798f\u4eba\u7c7b\u7684\u65b9\u5411\u3002<\/div>\n
\u00a0<\/div>\n
05\u00a0\u57fa\u56e0\u7597\u6cd5\u4fee\u590d\u5c0f\u9f20\u80da\u80ce\u81f4\u547d\u7a81\u53d8<\/div>\n\n
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\u2022\u00a0\u6280\u672f\u7a81\u7834\uff1a\u901a\u8fc7\u817a\u76f8\u5173\u75c5\u6bd2\uff08AAV\uff09\u8f7d\u4f53\u5728\u5c0f\u9f20\u5b50\u5bab\u4e2d\u5bf9\u6208\u8c22\u75c5\u80ce\u513f\u8fdb\u884c\u6ce8\u5c04\u6cbb\u7597\uff0c\u4f7f\u5176\u66f4\u597d\u5730\u964d\u89e3\u8102\u7c7b\u5206\u5b50\uff0c\u8ba9\u6208\u8c22\u75c5\u4e2d\u7f3a\u4e4f\u7684\u9176\u5f97\u5230\u91cd\u65b0\u8868\u8fbe\uff0c\u5b9e\u73b0\u5728\u5c0f\u9f20\u51fa\u751f\u524d\u5bf9\u81f4\u547d\u7a81\u53d8\u8fdb\u884c\u4fee\u590d\u3002<\/div>\n
\u2022\u00a0\u7814\u7a76\u9886\u57df\uff1a\u57fa\u56e0\u7597\u6cd5<\/div>\n
\u2022\u00a0\u4e3b\u8981\u7814\u7a76\u56e2\u961f\uff1aSimon Waddington\u56e2\u961f\uff08UCL\u5973\u6027\u5065\u5eb7\u7814\u7a76\u6240<\/div>\n
\u2022\u00a0\u5e94\u7528\u524d\u666f\uff1a\u9057\u4f20\u75be\u75c5\u6cbb\u7597<\/div>\n
\u2022\u00a0\u8bba\u6587\u53d1\u8868\uff1a2018\u5e747\u670816\u65e5\u300aNature Medicine\u300b\uff0chttps:\/\/www.nature.com\/articles\/s41591-018-0106-7<\/div>\n
\u62d3\u5c55\u9605\u8bfb<\/div>\n
\u5bf9\u4e8eSMA\u3001\u8840\u53cb\u75c5\u548c\u6208\u8c22\u75c5\u7b49\u96be\u6cbb\u6108\u7684\u81f4\u547d\u9057\u4f20\u75be\u75c5\uff0c\u57fa\u56e0\u7597\u6cd5\u7684\u51fa\u73b0\u662f\u4e00\u4e2a\u91cd\u5927\u7a81\u7834\uff0c\u7279\u522b\u662f\u51fa\u751f\u524d\u5bf9\u7a81\u53d8\u8fdb\u884c\u4fee\u590d\u3002\u9996\u6b3e\u83b7\u6279\u4e0a\u5e02\u7684\u57fa\u56e0\u7597\u6cd5\u662f\u6765\u81eaSpark Therapeutics\u7684Luxturna\uff0c\u7528\u4e8e\u6cbb\u7597\u5148\u5929\u6027\u9ed1\u6726\uff0c\u5176\u8840\u53cb\u75c5\u57fa\u56e0\u7597\u6cd5\u6b63\u5728\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\uff1b\u8bfa\u534e\u3001Bluebird\u7684\u57fa\u56e0\u7597\u6cd5\u5df2\u7533\u8bf7\u4e0a\u5e02\u7b49\u5f85\u5ba1\u6279\uff0c\u5206\u522b\u9488\u5bf91\u578bSMA\u548c\u03b2-\u5730\u8d2b\uff0c\u6709\u671b\u660e\u5e74\u4e0a\u5e02\u3002<\/div>\n
\u00a0<\/div>\n
06\u00a0\u9996\u6b21\u5f00\u53d1\u51fa\u4eba\u8111\u80bf\u7624\u7c7b\u5668\u5b98<\/div>\n\n
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\u2022\u00a0\u6280\u672f\u7a81\u7834\uff1a\u9996\u6b21\u5728\u57f9\u517b\u76bf\u4e2d\u5efa\u7acb\u4e86\u8111\u80bf\u7624\u7c7b\u5668\u5b98\u6a21\u578b\uff0c\u901a\u8fc7\u57fa\u56e0\u7ec4\u7f16\u8f91\u6280\u672f\uff0c\u5c06\u4e34\u5e8a\u53d1\u73b0\u7684\u81f4\u764c\u7a81\u53d8\u5f15\u5165\u4eba\u8111\u7c7b\u5668\u5b98\u6a21\u578b\uff0c\u501f\u6b64\u6a21\u62df\u539f\u53d1\u6027\u8111\u80bf\u7624\u7684\u53d1\u751f\u3001\u53d1\u5c55\u8fc7\u7a0b\u3002<\/div>\n
\u2022\u00a0\u7814\u7a76\u9886\u57df\uff1a\u518d\u751f\u533b\u5b66<\/div>\n
\u2022\u00a0\u4e3b\u8981\u7814\u7a76\u56e2\u961f\uff1aJ\u00fcrgen A. Knoblich\u7814\u7a76\u7ec4\uff08\u5965\u5730\u5229\u79d1\u5b66\u9662\u5206\u5b50\u751f\u7269\u6280\u672f\u7814\u7a76\u6240\uff09<\/div>\n
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\u2022\u00a0\u8bba\u6587\u53d1\u8868\uff1a2018\u5e747\u670823\u65e5\u300aNature Method\u300b\uff0chttps:\/\/www.nature.com\/articles\/s41592-018-0070-7<\/div>\n
\u62d3\u5c55\u9605\u8bfb<\/div>\n
\u7c7b\u5668\u5b98\u6280\u672f\u88ab\u300aNature Method\u300b\u8bc4\u4e3a2017\u5e74\u751f\u547d\u79d1\u5b66\u9886\u57df\u5e74\u5ea6\u6280\u672f\uff0c\u4f5c\u4e3a\u8fd1\u51e0\u5e74\u5f02\u519b\u7a81\u8d77\u53d1\u5c55\u8fc5\u901f\u7684\u65b0\u5174\u6280\u672f\uff0c\u5b9e\u73b0\u6700\u5927\u7a0b\u5ea6\u6a21\u62df\u4f53\u5185\u5668\u5b98\uff0c\u79d1\u5b66\u5bb6\u5df2\u57f9\u517b\u51fa\u7ed3\u76f4\u80a0\u764c\u3001\u80c3\u764c\u3001\u8180\u80f1\u764c\u7b49\u591a\u4e2a\u80bf\u7624\u7c7b\u5668\u5b98\u6a21\u578b\uff0c\u53ef\u4ee5\u5feb\u901f\u9a8c\u8bc1\u836f\u7269\u5bf9\u60a3\u8005\u7684\u7597\u6548\uff0c\u5927\u5e45\u51cf\u5c11\u8bd5\u9519\u6210\u672c\u3002<\/div>\n
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07\u00a0\u4eba\u9020\u5355\u67d3\u8272\u4f53\u771f\u6838\u7ec6\u80de<\/div>\n\n
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\"?wx_fmt=jpeg\"\/<\/figure><\/div>\n\n
\u2022\u00a0\u6280\u672f\u7a81\u7834\uff1a\u4e2d\u56fd\u79d1\u5b66\u5bb6\u9996\u521b\u4eba\u9020\u5355\u67d3\u8272\u4f53\u771f\u6838\u7ec6\u80de\uff0c\u917f\u9152\u9175\u6bcd\u768416\u6761\u67d3\u8272\u4f53\u5408\u6210\u4e3a\u4e00\u6761\uff0c\u4e14\u6ca1\u6709\u91cd\u5927\u751f\u957f\u7f3a\u9677<\/div>\n
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\u2022\u00a0\u5e94\u7528\u524d\u666f\uff1a\u7814\u7a76\u67d3\u8272\u4f53\u75be\u75c5\u3001\u4eba\u7c7b\u7aef\u7c92\u529f\u80fd\u53ca\u7ec6\u80de\u8870\u8001<\/div>\n
\u2022\u00a0\u8bba\u6587\u53d1\u8868\uff1a2018\u5e748\u67082\u65e5\u300aNature\u300b\uff0chttps:\/\/www.nature.com\/articles\/s41586-018-0382-x<\/div>\n
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1\uff09\u5408\u6210\u751f\u7269\u5b66\u4e13\u5bb6\u4e13\u8bbf\uff1a\u6e05\u534e\u5927\u5b66\u6234\u4fca\u5f6a\u535a\u58eb<\/a>\u00a0|\u00a0\u534e\u5927\u57fa\u56e0\u6c88\u73a5<\/a><\/div>\n
2\uff09\u917f\u9152\u9175\u6bcd\u901a\u5e38\u662f\u7814\u7a76\u67d3\u8272\u4f53\u5f02\u5e38\u7684\u91cd\u8981\u6a21\u578b\uff0c\u51761\/3\u57fa\u56e0\u548c\u4eba\u7c7b\u57fa\u56e0\u540c\u6e90\uff0c\u4ece2017\u5e74\u4eba\u5de5\u5408\u6210\u9175\u6bcd\u57fa\u56e0\u7ec4\u9879\u76ee\uff08Sc2.0\uff09\u76845\u6761\u67d3\u8272\u4f53\u7684\u8bbe\u8ba1\u4e0e\u5408\u6210\u52302018\u5e74\u4eba\u9020\u5355\u67d3\u8272\u4f53\u771f\u6838\u7ec6\u80de\uff0c\u53ef\u89c1\u57fa\u56e0\u5408\u6210\u7684\u5feb\u901f\u8fed\u4ee3\u3002\u6839\u636e\u6c5f\u535a\u58eb\u5728\u57fa\u56e0\u61672018\u5e74\u79c1\u8463\u4f1a\u62a5\u544a<\/a>\uff0c\u76f8\u5173\u884c\u4e1a\u6807\u51c6\u6b63\u5728\u5236\u5b9a\uff0c\u4e0d\u4ec5\u7528\u4e8e\u75be\u75c5\u6a21\u578b\u7814\u7a76\uff0c\u66f4\u6709\u52a9\u4e8e\u89e3\u51b3\u7eff\u8272\u80fd\u6e90\u548c\u73af\u5883\u4fdd\u62a4\u7b49\u95ee\u9898\u3002<\/div>\n
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08\u00a0\u65b0\u578bCAR-T\u7ec6\u80de\u7a81\u7834\u8840\u8111\u5c4f\u969c<\/div>\n\n
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\"?wx_fmt=jpeg\"\/<\/figure><\/div>\n\n
\u2022\u00a0\u6280\u672f\u7a81\u7834\uff1a\u5bf9T\u7ec6\u80de\u8868\u9762CD6\u86cb\u767d\u8fdb\u884c\u4e86\u4fee\u9970\uff0c\u589e\u5f3a\u4e0eALCAM\u7684\u7ed3\u5408\u80fd\u529b\uff0c\u4e34\u5e8a\u524d\u8bd5\u9a8c\u663e\u793a\u53ef\u4ee5\u7a7f\u900f\u5185\u76ae\uff0c\u6d78\u6da6\u5230\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u548c\u9ad3\u6bcd\u7ec6\u80de\u7624\uff0c\u5ef6\u957f\u5c0f\u9f20\u751f\u5b58\u671f\u3002<\/div>\n
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\u2022\u00a0\u8bba\u6587\u53d1\u8868\uff1a2018\u5e749\u67086\u65e5\u300aNature\u300b\uff0chttps:\/\/www.nature.com\/articles\/s41586-018-0499-y<\/div>\n
\u62d3\u5c55\u9605\u8bfb<\/div>\n
\u5065\u5168\u7684\u8840\u8111\u5c4f\u969c\u662f\u8111\u90e8\u7684\u91cd\u8981\u9632\u7ebf\uff0c\u4f46\u662f\u5728\u764c\u7ec6\u80de\u7684\u5229\u7528\u4e0b\uff0c\u8840\u8111\u5c4f\u969c\u6210\u4e3a\u5176\u5728\u5927\u8111\u5185\u751f\u957f\u7684\u4fdd\u62a4\u4f1e\uff0c\u514d\u75ab\u7ec6\u80de\u5374\u901a\u5e38\u88ab\u62d2\u4e4b\u95e8\u5916\uff0c\u4fee\u9970\u540e\u53ef\u4ee5\u7a81\u7834\u8840\u8111\u5c4f\u969c\u7684CAR-T\u7ec6\u80de\u5c06\u6709\u671b\u6cbb\u6108\u987d\u56fa\u7684\u8111\u80f6\u8d28\u7624\u3002<\/div>\n
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\"RmFicvQBAkgDibZQn4T2GZAao7CiatY7SqPerlR2ThpYNOTfd1mer4EkGKDb1SXRnMVA4GuQEsZEu0Zzc5CvzY3Rg\"\/<\/figure><\/div>\n\n
\u2022\u00a0\u6280\u672f\u7a81\u7834\uff1a\u6784\u5efa\u4eba\u5de5\u667a\u80fd\u7a0b\u5e8fAlphaFold\uff0c\u53ef\u901a\u8fc7\u57fa\u56e0\u5e8f\u5217\u9884\u6d4b\u86cb\u767d\u8d283D\u7ed3\u6784<\/div>\n
\u2022\u00a0\u7814\u7a76\u9886\u57df\uff1a\u86cb\u767d\u8d28\u7ed3\u6784<\/div>\n
\u2022\u00a0\u4e3b\u8981\u7814\u7a76\u56e2\u961f\uff1aDeepMind<\/div>\n
\u2022\u00a0\u5e94\u7528\u524d\u666f\uff1a\u9884\u6d4b\u9776\u70b9\u86cb\u767d\u8d28\u4e09\u7ef4\u7ed3\u6784\uff0c\u52a0\u901f\u65b0\u836f\u7b5b\u9009<\/div>\n
\u2022\u00a0\u53c2\u8003\u94fe\u63a5\uff1ahttps:\/\/deepmind.com\/blog\/alphafold\/<\/div>\n
\u62d3\u5c55\u9605\u8bfb<\/div>\n
1\uff09\u533b\u5b66\u4eba\u5de5\u667a\u80fd\u9886\u57df\u4e13\u5bb6\u4e13\u8bbf\uff1a\u9c81\u5174\u534e\u6559\u6388<\/a><\/div>\n
2\uff092018\u5e74AI\u5728\u751f\u547d\u5065\u5eb7\u9886\u57df\u7684\u5e94\u7528\u66f4\u4e3a\u6210\u719f\uff0c\u5982\u773c\u75be\u7b5b\u67e5\u3001\u764c\u75c7\u8bca\u65ad\u3001\u836f\u7269\u7814\u53d1\u3001\u9884\u6d4b\u5fc3\u810f\u75be\u75c5\u98ce\u9669\u7b49\u3002\u751f\u547d\u5065\u5eb7\u9886\u57df\u56e0\u4e3a\u57fa\u56e0\u6d4b\u5e8f\u3001\u8d28\u8c31\u3001\u82af\u7247\u7b49\u751f\u7269\u4fe1\u606f\u89e3\u6790\u5de5\u5177\u51fa\u73b0\uff0c\u79ef\u7d2f\u4e86\u5927\u91cf\u7ec4\u5b66\u5927\u6570\u636e\uff0c\u4ece\u6570\u636e\u8303\u5f0f\u548c\u6210\u672c\u4e0a\u662fAI\u7684\u5f88\u597d\u8bad\u7ec3\u8f93\u5165\uff0cBT\u548cAI\u7684\u7ed3\u5408\u53ef\u80fd\u4fc3\u4f7fBI\uff0c\u7279\u522b\u662f\u5728\u4eba\u5de5\u673a\u5668\u62df\u4eba\u5316\u4e0a\u7684\u8d4b\u80fd\u652f\u6301\u3002<\/div>\n
\u00a0<\/div>\n
10\u00a0ctDNA\u7247\u6bb5\u5927\u5c0f\u5206\u6790\u52a9\u529b\u764c\u75c7\u65e9\u7b5b<\/div>\n\n
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