\n![\"RmFicvQBAkgCuC54K47siaoibvbClYbpoQdmoEA7Yo9T0l4l5c9wsK8DWv13zXvBYojNDUX4HpbxOEe8enSicCuVVg\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCuC54K47siaoibvbClYbpoQdmoEA7Yo9T0l4l5c9wsK8DWv13zXvBYojNDUX4HpbxOEe8enSicCuVVg.gif\")
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<\/figure><\/div>\n\n<\/div>\n\u5173\u952e\u8bcd\/\u5e74\u5ea6\u76d8\u70b9 \u4e34\u5e8a \u6587\/\u57fa\u56e0\u6167<\/div>\n
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\u8fd1\u5e74\u6765\u5728\u653f\u7b56\u548c\u8d44\u672c\u7684\u52a9\u63a8\u4e0b\uff0c\u57fa\u56e0\u884c\u4e1a\u8d70\u8fc7\u5feb\u901f\u6269\u5f20\u671f\uff0c\u6280\u672f\u5de5\u5177\u5feb\u901f\u8fed\u4ee3\uff082018\u5e74\u6280\u672f\u76d8\u70b9<\/a>\uff09\uff0c\u653f\u7b56\u7a97\u53e3\u671f\u5ef6\u957f\uff082018\u5e74\u653f\u7b56\u76d8\u70b9<\/a>\uff09\uff0c\u5f53\u4e0b\u6b63\u503c\u8d44\u672c\u5bd2\u51ac\uff082018\u5e74\u6295\u878d\u8d44\u76d8\u70b9<\/a>\uff09\u6b63\u662f\u5bf9\u4f01\u4e1a\u786c\u5b9e\u529b\u7684\u8003\u91cf\uff0c\u4e5f\u4f5c\u4e3a\u884c\u4e1a\u5feb\u901f\u53d1\u5c55\u7684\u7f13\u51b2\u3002\u7531\u4e8e\u57fa\u7840\u7814\u7a76\u7684\u957f\u671f\u79ef\u6dc0\uff0c\u4e34\u5e8a\u5e94\u7528\u5728\u4eca\u5e74\u4ecd\u6709\u4e0d\u51e1\u7a81\u7834\u3002\u57fa\u56e0\u6167\u7684\u5e74\u5ea6\u57fa\u56e0\u884c\u4e1a\u76d8\u70b9\u7cfb\u5217\u7b2c\u56db\u7bc7\u68b3\u7406\u4e862018\u5e74\u5341\u5927\u4e34\u5e8a\u8fdb\u5c55\uff0c\u6b22\u8fce\u7559\u8a00\u8ba8\u8bba\uff0c\u7cbe\u9009\u7559\u8a00\u8005\u5c06\u4f1a\u83b7\u5f97\u57fa\u56e0\u6167\u539f\u521b\u300a2019\u5e74\u57fa\u56e0\u884c\u4e1a\u62a5\u544a\u300b\u4e00\u4efd\u3002<\/div>\n
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\n\n
\n![\"RmFicvQBAkgBx1UtZUYW4BgSfiaibHgOrLCvLU4YiawuYbbDWhesE8TQgkoqibYVnibkQibPw0j1NNyY8bGcKFmXhgKdg\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBx1UtZUYW4BgSfiaibHgOrLCvLU4YiawuYbbDWhesE8TQgkoqibYVnibkQibPw0j1NNyY8bGcKFmXhgKdg.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u5212\u91cd\u70b9\u00a0\u00a0<\/div>\n
\u2022\u00a0 AI\u8bca\u65ad\u591a\u79cd\u75be\u75c5\u8363\u767b\u300aCell\u300b\u5c01\u9762<\/div>\n
\u2022\u00a0 \u65e0\u521b\u8840\u6db2\u68c0\u6d4b\u9884\u6d4b\u65e9\u4ea7<\/div>\n
\u2022\u00a0 \u963f\u8328\u6d77\u9ed8\u75c7\u6216\u4e0e\u75c5\u6bd2\u611f\u67d3\u6709\u5173<\/div>\n
\u2022\u4e2d\u56fd\u6297\u764c\u521b\u65b0\u836f\u4e34\u5e8a\u7814\u7a76\u9996\u767bJAMA<\/div>\n
\u2022\u00a0\u00a0\u6211\u56fd\u9996\u4e2a\u80bf\u7624NGS\u57fa\u56e0\u68c0\u6d4b\u8bd5\u5242\u76d2\u4e0a\u5e02<\/div>\n
\u2022\u00a0 \u9996\u6b3eRNAi\u7597\u6cd5\u4e0a\u5e02<\/div>\n
\u2022\u00a0\u00a0iPS\u7ec6\u80de\u9996\u6b21\u6cbb\u7597\u4eba\u7c7b\u5e15\u91d1\u68ee\u75c5<\/div>\n
\u2022\u00a0\u00a0FDA\u6279\u51c6\u9996\u4e2a\u57fa\u56e0\u7f16\u8f91\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c<\/div>\n
\u2022\u00a0\u00a0TMB\u5199\u5165\u6700\u65b0NCCN\u6307\u5357<\/div>\n
\u2022\u00a0\u00a0\u201c\u7caa\u83cc\u79fb\u690d\u201d\u7f13\u89e3\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u5e76\u53d1\u75c7<\/div>\n
\uff08\u4ee5\u4e0b\u4e8b\u4ef6\u6309\u65f6\u95f4\u5148\u540e\u6392\u5e8f\uff09<\/div>\n
\u00a0<\/div>\n
01\u3001AI\u8bca\u65ad\u591a\u79cd\u75be\u75c5\u8363\u767b\u300aCell\u300b\u5c01\u9762<\/div>\n\n
\n![\"RmFicvQBAkgAFYSTibQhp60TXKWbOOibv5Mj8v3RCwJ24icIaicbllyDibNSdTBkDAwwv14ZnUpBMJ6SOic6OicoItqJYQ\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAFYSTibQhp60TXKWbOOibv5Mj8v3RCwJ24icIaicbllyDibNSdTBkDAwwv14ZnUpBMJ6SOic6OicoItqJYQ.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u2022\u00a0\u4e34\u5e8a\u7a81\u7834\uff1a2018\u5e742\u670823\u65e5\uff0c\u534e\u4eba\u5b66\u8005\u5f20\u5eb7\u6559\u6388\u56e2\u961f\u5e26\u6765\u7684AI\u5f71\u50cf\u8bca\u65ad\u7cfb\u7edf\u8363\u767b\u300aCell\u300b\u5c01\u9762\uff0c\u8be5\u7cfb\u7edf\u80fd\u7cbe\u786e\u8bca\u65ad\u9ec4\u6591\u53d8\u6027\u548c\u7cd6\u5c3f\u75c5\u6027\u9ec4\u6591\u6c34\u80bf\u8fd9\u4e24\u79cd\u773c\u75c5\uff0c\u8fd8\u51c6\u786e\u5730\u533a\u5206\u7ec6\u83cc\u6027\u548c\u75c5\u6bd2\u6027\u80ba\u708e\u3002<\/div>\n
\u2022\u00a0\u8bd5\u9a8c\u7814\u7a76\uff1a\u8bca\u65ad\u9ec4\u6591\u53d8\u6027\u3001\u9ec4\u6591\u6c34\u80bf\u7684\u51c6\u786e\u6027\u8fbe\u523096.6%\uff0c\u7075\u654f\u6027\u8fbe\u523097.8%\uff0c\u7279\u5f02\u6027\u8fbe\u523097.4%\uff0c\u68c0\u6d4b\u51c6\u786e\u7387\u8fbe\u5230\u66f2\u7ebf\u4e0b\u9762\u79ef99.9%\u3002\u533a\u5206\u7ec6\u83cc\u6027\u80ba\u708e\u548c\u75c5\u6bd2\u6027\u80ba\u708e\u7684\u51c6\u786e\u6027\u8fbe\u523090.7%\uff0c\u7075\u654f\u6027\u8fbe\u523088.6%\uff0c\u7279\u5f02\u6027\u8fbe\u523090.9%\u3002<\/div>\n
\u2022\u00a0\u9488\u5bf9\u75be\u75c5\uff1a\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\u548c\u7cd6\u5c3f\u75c5\u6027\u9ec4\u6591\u6c34\u80bf\uff0c\u513f\u7ae5\u7ec6\u83cc\u6027\u548c\u75c5\u6bd2\u6027\u80ba\u708e<\/div>\n
\u2022\u00a0\u4e3b\u8981\u7814\u7a76\u56e2\u961f\uff1a\u5e7f\u5dde\u533b\u79d1\u5927\u5b66\u3001\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\u5f20\u5eb7\u6559\u6388\uff0c\u56db\u5ddd\u5927\u5b66\u3001\u5927\u8fde\u5317\u6d77\u533b\u9662\u3001\u4e0a\u6d77\u7b2c\u4e00\u4eba\u6c11\u533b\u9662\u3001\u9996\u90fd\u533b\u79d1\u5927\u5b66\u7b49\u3002<\/div>\n
\u2022\u00a0\u8bba\u6587\u53d1\u8868\uff1ahttps:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(18)30154-5<\/div>\n
\u62d3\u5c55\u9605\u8bfb<\/div>\n
1\uff09\u533b\u5b66\u4eba\u5de5\u667a\u80fd\u9886\u57df\u4e13\u5bb6\u4e13\u8bbf\uff1a\u9c81\u5174\u534e\u6559\u6388<\/a><\/div>\n
2\uff09\u4eba\u5de5\u667a\u80fd\u76ee\u524d\u5728\u7cbe\u51c6\u533b\u7597\u591a\u4e2a\u9886\u57df\u521d\u9732\u5934\u89d2\uff0c\u7ed3\u5408\u5f71\u50cf\u5b66\u53ef\u4ee5\u7528\u4e8e\u9884\u6d4b\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u513f\u7ae5\u81ea\u95ed\u75c7\u3001\u963f\u8328\u6d77\u9ed8\u75c7\uff0c\u8bca\u65ad\u75be\u75c5\u4ee5\u53ca\u8f85\u52a9\u80bf\u7624\u5fae\u521b\u624b\u672f\uff08\u8be6\u60c5<\/a>\uff09\u3002\u56fd\u5bb6\u5668\u5ba1\u4e2d\u5fc3\u5df2\u7ec4\u5efaAI\u7814\u7a76\u7ec4\uff0c\u9884\u8ba1\u660e\u5e74\u5c06\u6709\u90e8\u5206AI\u533b\u7597\u4ea7\u54c1\u4e0a\u5e02\uff0c\u800c\u7b26\u5408\u4e34\u5e8a\u5e94\u7528\u573a\u666f\u7684\u9700\u6c42\u548c\u53cb\u597d\u7684\u4eba\u673a\u4ea4\u4e92\u539f\u5219\u90fd\u662f\u4ea7\u54c1\u7684\u6838\u5fc3\u8981\u7d20\u3002<\/div>\n
\u00a0<\/div>\n
02\u3001\u65e0\u521b\u8840\u6db2\u68c0\u6d4b\u9884\u6d4b\u65e9\u4ea7<\/div>\n\n
\n![\"RmFicvQBAkgAFYSTibQhp60TXKWbOOibv5MZSpk7aSCz93vSkzic2oicuX8icibbf2aA5OeckRumL2bseXaoZsTYGscyw\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAFYSTibQhp60TXKWbOOibv5MZSpk7aSCz93vSkzic2oicuX8icibbf2aA5OeckRumL2bseXaoZsTYGscyw.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u2022\u00a0\u4e34\u5e8a\u7a81\u7834\uff1a2018\u5e746\u67088\u65e5\uff0c\u7f8e\u56fd\u79d1\u5b66\u5bb6\u5e26\u6765\u4e00\u79cd\u53ef\u4ee5\u9884\u6d4b\u65e9\u4ea7\u7684\u65e0\u521b\u8840\u6db2\u68c0\u6d4b\u6280\u672f\u5e76\u53d1\u8868\u5728\u300aScience\u300b\uff0c\u80fd\u591f\u4ee575%-80%\u7684\u51c6\u786e\u7387\u9884\u6d4b\u5b55\u5987\u662f\u5426\u4f1a\u65e9\u4ea7\uff0c\u8fd8\u53ef\u4ee5\u9884\u4f30\u80ce\u513f\u7684\u80ce\u9f84\u6216\u5b55\u5987\u7684\u9884\u4ea7\u671f\u3002<\/div>\n
\u2022\u00a0\u8bd5\u9a8c\u7814\u7a76\uff1a\u901a\u8fc7\u5bf938\u540d\u7f8e\u56fd\u5973\u6027\u8840\u6db2\u68c0\u6d4b\uff0c\u53d1\u73b0\u6765\u81ea\u6bcd\u4eb2\u548c\u80ce\u76d8\u76847\u79cd\u57fa\u56e0\u7684\u6e38\u79bbRNA(CLCN3\u3001DAPP1\u3001PPBP\u3001MAP3K7CL\u3001MOB1B\u3001RAB27B\u548cRGS18)\u7684\u6c34\u5e73\u53ef\u4ee5\u9884\u6d4b\u65e9\u4ea7\uff0c\u5176\u8840\u6db2\u68c0\u6d4b\u6280\u672f\u51c6\u786e\u8bc6\u522b\u4e865\u4e2a\u65e9\u4ea7\u6837\u672c\u4e2d\u76844\u4e2a\uff1b\u572818\u4e2a\u8db3\u6708\u6837\u672c\u4e2d\uff0c\u8be5\u6280\u672f\u9519\u8bef\u8bc6\u522b\u4e863\u4e2a\u3002<\/div>\n
\u2022\u00a0\u9488\u5bf9\u573a\u666f\uff1a\u65e9\u4ea7<\/div>\n
\u2022\u00a0\u4e3b\u8981\u7814\u7a76\u56e2\u961f\uff1a\u7f8e\u56fd\u65af\u5766\u798f\u5927\u5b66\u3001\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u3001\u963f\u62c9\u5df4\u9a6c\u5927\u5b66\u548c\u4e39\u9ea6\u56fd\u5bb6\u8840\u6e05\u7814\u7a76\u6240<\/div>\n
\u2022\u00a0\u8bba\u6587\u53d1\u8868\uff1ahttp:\/\/science.sciencemag.org\/content\/360\/6393\/1133.full<\/div>\n
\u62d3\u5c55\u9605\u8bfb<\/div>\n
1\uff09\u5987\u5e7c\u7cbe\u51c6\u533b\u7597\u9886\u57df\u4e13\u5bb6\u4e13\u8bbf\uff1a\u59da\u5b8f<\/a>\u00a0|\u00a0\u9ec4\u5c1a\u5fd7<\/a>\u00a0|\u00a0\u9ec4\u56fd\u82f1\u00a0|\u00a0<\/a>\u6881\u5fd7\u6e05<\/a>\u00a0|\u00a0<\/a>\u9ec4\u6d9b\u751f<\/a><\/div>\n
2\uff09\u65e9\u4ea7\u662f\u76ee\u524d\u56f0\u6270\u4e34\u5e8a\u533b\u751f\u7684\u4e00\u4e2a\u96be\u9898\uff0c\u5168\u7403\u6bcf\u5e74\u7ea6\u67091500\u4e07\u5a74\u513f\u53d7\u5230\u65e9\u4ea7\u5f71\u54cd\uff0c\u4e25\u91cd\u65f6\u4e5f\u4f1a\u81f4\u547d\uff0c\u76ee\u524d\u4ecd\u7f3a\u4e4f\u6709\u6548\u65b9\u5f0f\u9884\u6d4b\u548c\u9632\u6b62\u65e9\u4ea7\u73b0\u8c61\uff0c\u6b64\u6b21\u7814\u7a76\u63d0\u4f9b\u4e86\u4e00\u4e2a\u601d\u8def\uff0c\u4f46\u662f\u7531\u4e8e\u6837\u672c\u91cf\u548c\u53d7\u8bd5\u8005\u5747\u4e3a\u65e9\u4ea7\u9ad8\u5371\u4eba\u7fa4\u6bd4\u8f83\u5c40\u9650\uff0c\u671f\u5f85\u540e\u7eed\u7814\u7a76\uff0c\u6709\u671b\u6210\u4e3a\u8d85\u58f0\u6ce2\u6280\u672f\u7684\u8865\u5145\u6216\u66ff\u4ee3\u54c1\u3002<\/div>\n
\u00a0<\/div>\n
03\u3001\u963f\u8328\u6d77\u9ed8\u75c7\u6216\u4e0e\u75c5\u6bd2\u611f\u67d3\u6709\u5173<\/div>\n\n
\n![\"?wx_fmt=jpeg\"\/](\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/RmFicvQBAkgAFYSTibQhp60TXKWbOOibv5MbKuxGFZ2Y7Xx9hE6geL4smQVNLqr4NR1OP903bRW9Oyyx7enL1ibpHQ\/?wx_fmt=jpeg\")
<\/figure><\/div>\n\n
\u2022\u00a0\u4e34\u5e8a\u7a81\u7834\uff1a2018\u5e746\u670822\u65e5\uff0c\u300aCell\u300b\u5b50\u520a\u300aNeuron\u300b\u62a5\u9053\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0c\u963f\u8328\u6d77\u9ed8\u75c7\u53ef\u80fd\u4e0e\u4eba\u7c7b\u75b1\u75b9\u75c5\u6bd2HHV-6A\u548cHHV-7\u611f\u67d3\u6709\u5173\uff0c\u4e3a\u96be\u6cbb\u6108\u7684\u963f\u8328\u6d77\u9ed8\u75c7\u63d0\u4f9b\u4e86\u65b0\u7684\u6cbb\u7597\u601d\u8def\u3002<\/div>\n
\u2022\u00a0\u8bd5\u9a8c\u7814\u7a76\uff1a\u901a\u8fc7\u5bf9944\u4e2a\u5927\u8111\u6837\u672c\u7684\u5206\u6790\uff0c\u53d1\u73b0\u5728\u60a3\u8005\u5927\u8111\u6837\u672c\u4e2d\u4eba\u7c7b\u75b1\u75b9\u75c5\u6bd2\uff08HHV\uff096A\u4e0e7\u6c34\u5e73\u660e\u663e\u4e0a\u5347\uff0c\u4e14\u4e0e\u963f\u5179\u6d77\u9ed8\u75c5\u7684\u75c7\u72b6\u5448\u6b63\u76f8\u5173\uff0c\u5f71\u54cdBACE1\u3001PSEN1\u3001APBB2\u7b49\u963f\u8328\u6d77\u9ed8\u75c7\u98ce\u9669\u57fa\u56e0\u7684\u8868\u8fbe\u3002<\/div>\n
\u2022\u00a0\u9488\u5bf9\u75be\u75c5\uff1a\u963f\u8328\u6d77\u9ed8\u75c7<\/div>\n
\u2022\u00a0\u4e3b\u8981\u7814\u7a76\u56e2\u961f\uff1a\u897f\u5948\u5c71\u4f0a\u574e\u533b\u5b66\u9662<\/div>\n
\u2022\u00a0\u8bba\u6587\u53d1\u8868\uff1ahttps:\/\/www.cell.com\/neuron\/fulltext\/S0896-6273(18)30421-5<\/div>\n
\u62d3\u5c55\u9605\u8bfb<\/div>\n
\u76ee\u524d\u5c1a\u65e0\u6709\u6548\u7597\u6cd5\u5bf9\u963f\u8328\u6d77\u9ed8\u75c7\u8fdb\u884c\u9884\u9632\u6216\u8005\u6cbb\u7597\uff0c\u5b83\u7684\u6cbb\u7597\u65b9\u5411\u6b64\u524d\u591a\u805a\u7126\u4e8e\u03b2\u6dc0\u7c89\u6837\u86cb\u767d\uff0c\u5374\u8fce\u6765\u4e00\u7cfb\u5217\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5931\u8d25\u3002\u5173\u4e8e\u75c5\u6bd2\u611f\u67d3\u7684\u7814\u7a76\u7ed9\u836f\u4f01\u548c\u79d1\u5b66\u5bb6\u4e00\u4e2a\u65b0\u7684\u65b9\u5411\uff0c\u76ee\u524d\u4ecd\u5f85\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u75c5\u6bd2\u7684\u5177\u4f53\u4f5c\u7528\u673a\u5236\uff0c\u963f\u8328\u6d77\u9ed8\u75c7\u4e5f\u6216\u8bb8\u662f\u591a\u56e0\u7d20\u9a71\u52a8\u4e0b\u7684\u590d\u6742\u75be\u75c5\u3002<\/div>\n
\u00a0<\/div>\n
04\u3001\u4e2d\u56fd\u6297\u764c\u521b\u65b0\u836f\u4e34\u5e8a\u7814\u7a76\u9996\u767bJAMA<\/div>\n\n
\n![\"RmFicvQBAkgAFYSTibQhp60TXKWbOOibv5MvmSPTp49II0rrtibLXVRxOA6QaT216xjmRL3ZHyyu5IicS1iaqGYVUBSA\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAFYSTibQhp60TXKWbOOibv5MvmSPTp49II0rrtibLXVRxOA6QaT216xjmRL3ZHyyu5IicS1iaqGYVUBSA.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u2022\u00a0\u4e34\u5e8a\u7a81\u7834\uff1a2018\u5e746\u670826\u65e5\uff0c\u56fd\u9645\u9876\u5c16\u533b\u5b66\u671f\u520a\u300aJAMA\u300b\u5728\u7ebf\u5168\u6587\u53d1\u8868\u4e86\u544b\u55b9\u66ff\u5c3c\u4e09\u7ebf\u6cbb\u7597\u665a\u671f\u7ed3\u76f4\u80a0\u764c\u7684\u968f\u673a\u3001\u53cc\u76f2\u5168\u56fdIII\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08FRESCO\u7814\u7a76\uff09\u7ed3\u679c\uff0c\u8fd9\u662f\u4e2d\u56fd\u81ea\u4e3b\u7814\u53d1\u7684\u6297\u764c\u521b\u65b0\u836f\u4e34\u5e8a\u7814\u7a76\u9996\u6b21\u520a\u767bJAMA\uff0c\u53d7\u5230\u56fd\u9645\u533b\u5b66\u754c\u7684\u5145\u5206\u8ba4\u53ef\u3002\u76ee\u524d\u8be5\u836f\u5df2\u4e8e\u4eca\u5e749\u6708\u4e0a\u5e02\uff0c\u540c\u65f6\u4e5f\u5728\u7533\u8bf7\u65b0\u7684\u9002\u5e94\u75c7\u5982\u80ba\u764c\u548c\u80c3\u764c\u3002<\/div>\n
\u2022\u00a0\u8bd5\u9a8c\u7814\u7a76\uff1a\u7eb3\u5165416\u4f8b\u65e2\u5f80\u66fe\u63a5\u53d7\u81f3\u5c11\u4e24\u7ebf\u5316\u7597\u6216\/\u548c\u9776\u5411\u6cbb\u7597\u7684\u8f6c\u79fb\u6027\u6216\u665a\u671f\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff0c\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08mOS\uff09: 9.30 \u6bd46.57 \u4e2a\u6708 ( HR=0.65, P<0.001) \uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09: 3.71\u6bd41.84\u4e2a\u6708( HR=0.26, P<0.001)\uff1b\u603b\u7684\u5ba2\u89c2\u53cd\u5e94\u7387\uff08ORR\uff09: 4.7%\u6bd40 (P=0.012) \uff1b\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09: 62.2%\u6bd412.3%(P <0.001\uff09\u3002<\/div>\n
\u2022\u00a0\u9488\u5bf9\u75be\u75c5\uff1a\u665a\u671f\u7ed3\u76f4\u80a0\u764c<\/div>\n
\u2022\u00a0\u4e3b\u8981\u7814\u7a76\u56e2\u961f\uff1a\u4e0a\u6d77\u540c\u6d4e\u5927\u5b66\u9644\u5c5e\u4e1c\u65b9\u533b\u9662\u674e\u8fdb\u6559\u6388\uff0c\u5357\u4eac\u4e2d\u533b\u836f\u5927\u5b66\u9644\u5c5e\u516b\u4e00\u533b\u9662\u79e6\u53d4\u9035\u6559\u6388\u53ca\u56fd\u518528\u5bb6\u80bf\u7624\u4e2d\u5fc3\u3002<\/div>\n
\u2022\u00a0\u8bba\u6587\u53d1\u8868\uff1ahttps:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2685988<\/div>\n
\u62d3\u5c55\u9605\u8bfb<\/div>\n
\u4ece2006\u5e74\u7acb\u9879\u5230\u4eca\u5e74\u4e0a\u5e02\uff0c\u544b\u55b9\u66ff\u5c3c\u7684\u7814\u53d1\u8fc7\u7a0b\u5386\u7ecf12\u4e2a\u5e74\u5934\uff0c\u5b83\u7684\u987a\u5229\u4e0a\u5e02\u5f97\u76ca\u4e8e\u5728\u4e0a\u6d77\u8bd5\u70b9\u7684\u836f\u54c1\u4e0a\u5e02\u8bb8\u53ef\u4eba\u5236\u5ea6\uff08MAH\uff09\uff0c\u544b\u55b9\u66ff\u5c3c\u7531\u6b64\u8fdb\u5165\u65b0\u836f\u4f18\u5148\u5ba1\u8bc4\u901a\u9053\uff0c\u5728\u57fa\u7840\u8bbe\u65bd\u4e0d\u5b8c\u5584\u7684\u60c5\u51b5\u4e0b\uff0c\u8fd8\u80fd\u901a\u8fc7\u4ee3\u5de5\u5b8c\u6210\u751f\u4ea7\uff0c\u51cf\u8f7b\u4f01\u4e1a\u7814\u53d1\u8d1f\u62c5\u3002\u5728\u5927\u5200\u9614\u65a7\u7684\u653f\u7b56\u6539\u9769\u4e0b\uff0c\u6211\u56fd\u521b\u65b0\u539f\u7814\u836f\u8fce\u6765\u751f\u957f\u7684\u6c83\u571f\u3002<\/div>\n
\u00a0<\/div>\n
05\u3001\u80bf\u7624NGS\u7b2c\u4e00\u8bc1<\/div>\n\n
\n![\"?wx_fmt=jpeg\"\/](\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/RmFicvQBAkgBUD9OpeSHVpIFFWgsbs3V6pFQWrJOeLzEQWKuqOHIHzfTOE09fAol1wxNuhgicicjN1Ywbnfa8SISg\/?wx_fmt=jpeg\")
<\/figure><\/div>\n\n
\u2022\u00a0\u4e34\u5e8a\u7a81\u7834\uff1a2018\u5e747\u670823\u65e5\uff0c\u56fd\u5bb6\u836f\u76d1\u5c40\u6279\u51c6\u71c3\u77f3\u533b\u5b66\u201c\u4ebaEGFR \/ ALK \/ BRAF \/ KRAS \u57fa\u56e0\u7a81\u53d8\u8054\u5408\u68c0\u6d4b\u8bd5\u5242\u76d2\uff08\u53ef\u9006\u672b\u7aef\u7ec8\u6b62\u6d4b\u5e8f\u6cd5\uff09\u201d\u4e0a\u5e02\uff0c\u662f\u4e2d\u56fd\u9996\u4e2a\u57fa\u4e8eNGS\u53ca\u4f34\u968f\u8bca\u65ad\u6807\u51c6\u5ba1\u6279\u7684\u591a\u57fa\u56e0\u80bf\u7624\u7a81\u53d8\u8054\u5408\u68c0\u6d4b\u8bd5\u5242\u76d2\u3002<\/div>\n
\u2022\u00a0\u8bd5\u9a8c\u7814\u7a76\uff1a\u5728\u56db\u5ddd\u5927\u5b66\u534e\u897f\u533b\u9662\u3001\u4e0a\u6d77\u5e02\u80f8\u79d1\u533b\u9662\u7b495\u5bb6\u4e34\u5e8a\u8bd5\u9a8c\u673a\u6784\u5b8c\u6210\u4e86\u4e34\u5e8a\u8bd5\u9a8c\u3002\u7ecf\u6bd4\u8f83\u7814\u7a76\uff0c\u8003\u6838\u8bd5\u5242\u7684\u5b9a\u6027\u68c0\u6d4b\u7ed3\u679c\u9633\u6027\u7b26\u5408\u7387\u4e3a98.6% \uff0895%CI97.7%-99.3%\uff09\uff0c\u9634\u6027\u7b26\u5408\u7387\u4e3a94.0% \uff0895%CI91.6%-95.9%\uff09\uff0c\u603b\u7b26\u5408\u7387\u4e3a97.0% \uff0895%CI96.0%-97.8%\uff09\uff0c\u91c7\u7528\u5361\u65b9\u68c0\u9a8c\u8fdb\u884c\u7edf\u8ba1\u5b66\u5206\u6790\uff1ap-value=1\uff0c\u5177\u6709\u8f83\u597d\u7684\u68c0\u6d4b\u4e00\u81f4\u6027\u3002<\/div>\n
\u2022\u00a0\u9488\u5bf9\u75be\u75c5\uff1a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<\/div>\n
\u62d3\u5c55\u9605\u8bfb<\/div>\n
\u4e0e\u4f20\u7edf\u57fa\u56e0\u68c0\u6d4b\u624b\u6bb5\u76f8\u6bd4\uff0cNGS\u68c0\u6d4b\u7684\u7279\u70b9\u5728\u4e8e\u53ef\u4ee5\u5e73\u884c\u68c0\u6d4b\u591a\u57fa\u56e0\u3001\u591a\u4f4d\u70b9\uff0c\u4ee5\u53ca\u56ca\u62ec\u70b9\u7a81\u53d8\u3001\u63d2\u5165\u7f3a\u5931\u3001\u91cd\u6392(\u878d\u5408)\u7b49\u591a\u79cd\u53d8\u5f02\u5f62\u5f0f\u3002\u201c\u80bf\u7624NGS\u7b2c\u4e00\u8bc1\u201d\u7684\u83b7\u6279\u610f\u5473\u7740\u80bf\u7624NGS\u68c0\u6d4b\u6b63\u5f0f\u8fdb\u5165\u4e34\u5e8a\u533b\u9662\u68c0\u6d4b\u79d1\u5ba4\uff0c\u4e3a\u533b\u751f\u548c\u60a3\u8005\u63d0\u4f9b\u4e86\u591a\u79cd\u9776\u5411\u836f\u7269\u7684\u4e00\u7ad9\u5f0f\u68c0\u6d4b\u89e3\u51b3\u65b9\u6848\uff0c\u8282\u7701\u68c0\u6d4b\u6837\u672c\u548c\u68c0\u6d4b\u65f6\u95f4\u3002\u8fd9\u4e5f\u662f\u5728\u4e34\u5e8a\u9700\u6c42\u63a8\u52a8\u4e0b\uff0c\u57fa\u56e0\u68c0\u6d4b\u4f01\u4e1a\u548c\u76d1\u7ba1\u653f\u7b56\u7684\u53d1\u5c55\u548c\u8fdb\u6b65\u3002<\/div>\n
\u00a0<\/div>\n
06\u3001\u9996\u6b3eRNAi\u7597\u6cd5\u4e0a\u5e02<\/div>\n\n
\n![\"RmFicvQBAkgBUD9OpeSHVpIFFWgsbs3V6BjfLJ6JlX6GYTLRdQmnD1lxlINadeGxmyOtgfPAhD9ISL4W4RicTUPg\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBUD9OpeSHVpIFFWgsbs3V6BjfLJ6JlX6GYTLRdQmnD1lxlINadeGxmyOtgfPAhD9ISL4W4RicTUPg.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u2022\u00a0\u4e34\u5e8a\u7a81\u7834\uff1a2018\u5e748\u670811\u65e5\uff0cFDA\u6279\u51c6\u7531Alnylam\u7814\u53d1\u7684patisiran\u4e0a\u5e02\uff0c\u8fd9\u662f\u9996\u6b3eRNAi\u7597\u6cd5\uff0c\u7528\u4e8e\u6cbb\u7597\u4e00\u79cd\u81f4\u547d\u7684\u7f55\u89c1\u75c5\u79f0\u4e3ahATTR\u6dc0\u7c89\u6837\u53d8\u6027\u3002patisiran\u80fd\u6291\u5236\u7279\u5b9amRNA\u7684\u8868\u8fbe\uff0c\u6e05\u9664\u7ec4\u7ec7\u91cc\u7684\u6dc0\u7c89\u6837\u86cb\u767d\u6c89\u79ef\uff0c\u6062\u590d\u7ec4\u7ec7\u529f\u80fd\u3002<\/div>\n
\u2022\u00a0\u8bd5\u9a8c\u7814\u7a76\uff1a\u8be5\u7597\u6cd5\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u5982\u4e0a\uff0c\u572818\u4e2a\u6708\u65f6\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4patisiran\u663e\u8457\u51cf\u5c11\u4e86\u60a3\u8005\u7684\u795e\u7ecf\u5b66\u75c5\u53d8\u3002<\/div>\n
\u2022\u00a0\u9488\u5bf9\u75be\u75c5\uff1a\u7279\u5b9a\u7f55\u89c1\u75c5<\/div>\n
\u62d3\u5c55\u9605\u8bfb<\/div>\n
1\uff09\u7f55\u89c1\u75c5\u9886\u57df\u4e13\u5bb6\uff1a\u738b\u5955\u9e25<\/a>\u00a0|\u00a0\u5f13\u5b5f\u6625\u00a0|\u00a0<\/a>\u987e\u5927\u592b<\/a>\u00a0|\u00a0<\/a>\u9f9a\u7476\u7434<\/a>\u00a0|\u00a0<\/a>\u4e01\u6d01<\/a><\/div>\n
2\uff09RNAi\uff08RNA\u5e72\u6270\uff09\u7597\u6cd5\u539f\u7406\u662f\u5229\u7528\u5be1\u6838\u82f7\u9178\u4e0emRNA\u5e8f\u5217\u7ed3\u5408\uff0c\u6765\u8c03\u8282\u57fa\u56e0\u8868\u8fbe\uff0c\u8fd9\u4e2a\u6982\u5ff5\u65e9\u5728\u4e0a\u4e16\u7eaa\u4e03\u5341\u5e74\u4ee3\u5c31\u88ab\u63d0\u51fa\uff0c\u52302006\u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u6388\u4e88\u4e86\u53d1\u73b0RNAi\u673a\u5236\u7684\u4e24\u4f4d\u79d1\u5b66\u5bb6\uff0c\u5728\u79d1\u7814\u53d1\u73b0\u8f6c\u5316\u4e3a\u4e34\u5e8a\u6210\u679c\u7684\u8def\u4e0a\u662f\u6f2b\u957f\u4e14\u8270\u8f9b\u7684\uff0c\u79bb\u4e0d\u5f00\u57fa\u7840\u5b66\u79d1\u548c\u5de5\u5177\u7684\u8fdb\u6b65\u3001\u653f\u7b56\u6fc0\u52b1\u548c\u836f\u4f01\u7684\u7814\u53d1\u6295\u5165\uff0c\u8fd9\u4e5f\u662f\u8fd1\u51e0\u5341\u5e74\u6765\u521b\u65b0\u7597\u6cd5\u5c42\u51fa\u4e0d\u7a77\u7684\u8def\u5f84\u3002<\/div>\n
\u00a0<\/div>\n
07\u3001iPS\u7ec6\u80de\u9996\u6b21\u6cbb\u7597\u4eba\u7c7b\u5e15\u91d1\u68ee\u75c5<\/div>\n\n
\n![\"?wx_fmt=jpeg\"\/](\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/RmFicvQBAkgAFYSTibQhp60TXKWbOOibv5MzwH9CXcWz8yhaNzbuUWXbGVRUK2b9IDibOKRdx97Z6M7wJBZlFUGKlQ\/?wx_fmt=jpeg\")
<\/figure><\/div>\n\n
\u2022\u00a0\u4e34\u5e8a\u7a81\u7834\uff1a10\u6708\u4eac\u90fd\u5927\u5b66\u4eac\u90fd\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u533b\u9662\u9996\u6b21\u5229\u7528\u4eba\u7c7b\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de(iPS\u7ec6\u80de)\u5236\u4f5c\u7684\u795e\u7ecf\u7ec6\u80de\u5bf9\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u8fdb\u884c\u79fb\u690d\u6cbb\u7597\uff0c\u60a3\u8005\u6062\u590d\u60c5\u51b5\u826f\u597d\uff0c\u624b\u672f\u6548\u679c\u548c\u5b89\u5168\u6027\u8fd8\u9700\u957f\u671f\u89c2\u5bdf\u3002\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u4e8e\u4eca\u5e747\u6708\u83b7\u5f97\u65e5\u672c\u653f\u5e9c\u6279\u51c6\u3002<\/div>\n
\u2022\u00a0\u4e34\u5e8a\u524d\u8bd5\u9a8c\uff1aiPS\u7ec6\u80de\u7597\u6cd5\u6539\u5584\u4e86\u5e15\u91d1\u68ee\u75c5\u7334\u6a21\u578b\u7684\u795e\u7ecf\u529f\u80fd\uff08https:\/\/www.nature.com\/articles\/nature23664\uff09<\/div>\n
\u2022\u00a0\u9488\u5bf9\u75be\u75c5\uff1a\u5e15\u91d1\u68ee\u75c5<\/div>\n
\u2022\u00a0\u4e3b\u8981\u7814\u7a76\u56e2\u961f\uff1a\u65e5\u672c\u4eac\u90fd\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u533b\u9662<\/div>\n
\u2022\u00a0\u53c2\u8003\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/d41586-018-07407-9<\/div>\n
\u62d3\u5c55\u9605\u8bfb<\/div>\n
iPS\u7ec6\u80de\u662f\u901a\u8fc7\u5bf9\u6210\u719f\u4f53\u7ec6\u80de\u201c\u91cd\u65b0\u7f16\u7a0b\u201d\u57f9\u80b2\u51fa\u7684\u5e72\u7ec6\u80de\uff0c\u62e5\u6709\u4e0e\u80da\u80ce\u5e72\u7ec6\u80de\u76f8\u4f3c\u7684\u5206\u5316\u6f5c\u529b\uff0c\u7406\u8bba\u4e0a\uff0ciPS\u7ec6\u80de\u53ef\u4ee5\u4e3a\u60a3\u8005\u91cf\u8eab\u5b9a\u5236\uff0c\u907f\u514d\u5bf9\u5916\u6765\u7ec4\u7ec7\u4ea7\u751f\u514d\u75ab\u6392\u65a5\u53cd\u5e94\u3002\u4e2d\u56fd\u65e9\u57282017\u5e74\u5df2\u5f00\u59cb\u5229\u7528\u5e72\u7ec6\u80de\u7597\u6cd5\u6cbb\u7597\u5e15\u91d1\u68ee\u60a3\u8005\uff0c\u4f46\u662f\u91c7\u53d6\u7684\u65b9\u6cd5\u4e0d\u540c\uff0c\u4e3a\u60a3\u8005\u63d0\u4f9b\u7684\u662f\u7531\u80da\u80ce\u5e72\u7ec6\u80de\u5236\u6210\u7684\u795e\u7ecf\u524d\u4f53\u7ec6\u80de\u3002\u9700\u8981\u6ce8\u610f\u7684\u662f\uff0c\u4efb\u4f55\u4e00\u79cd\u65b0\u578b\u7597\u6cd5\u7684\u4e34\u5e8a\u8bd5\u9a8c\u90fd\u5e94\u51c6\u5907\u597d\u4e25\u683c\u7684\u4e34\u5e8a\u5ba1\u6279\u548c\u76d1\u7ba1\u5236\u5ea6\u3002<\/div>\n
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08\u3001FDA\u6279\u51c6\u9996\u4e2a\u57fa\u56e0\u7f16\u8f91\u4e34\u5e8a\u8bd5\u9a8c<\/div>\n\n
\n![\"RmFicvQBAkgBUD9OpeSHVpIFFWgsbs3V6pxhAzTphZTrj5tDNpsEMia8JhmXSQlAfFAxJE1Djwuzk2aFvdvamYlQ\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBUD9OpeSHVpIFFWgsbs3V6pxhAzTphZTrj5tDNpsEMia8JhmXSQlAfFAxJE1Djwuzk2aFvdvamYlQ.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u2022\u00a0\u4e34\u5e8a\u7a81\u7834\uff1a2018\u5e7410\u670810\u65e5\uff0cCrispr Therapeutics\u548c\u5176\u5408\u4f5c\u4f19\u4f34Vertex Pharmaceuticals\u5ba3\u5e03\uff0cFDA\u6279\u51c6\u4e25\u91cd\u9570\u72b6\u7ec6\u80de\u75be\u75c5\uff08SCD\uff09\u57fa\u56e0\u7f16\u8f91\u836f\u7269CTX001\u7684\u4e34\u5e8a\u65b0\u836f\u7533\u8bf7\uff0c\u8fd9\u662fFDA\u9996\u6b21\u6279\u51c6CRISPR\u57fa\u56e0\u7f16\u8f91\u836f\u7269\u8fdb\u884c\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/div>\n
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\u00a0<\/div>\n
09\u3001TMB\u5199\u5165\u6700\u65b0NCCN\u6307\u5357<\/div>\n\n
\n![\"0?wx_fmt=jpeg\"\/](\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/RmFicvQBAkgBUD9OpeSHVpIFFWgsbs3V6I83gfZJh4pGXAqgndaMibbIeD1NMR5qQpsNNCiaiad6usx0LXGOO7pIFw\/0?wx_fmt=jpeg\")
<\/figure><\/div>\n\n
\u2022\u00a0\u4e34\u5e8a\u7a81\u7834\uff1a2018\u5e7410\u6708\uff0c\u7f8e\u56fd\u56fd\u5bb6\u7efc\u5408\u764c\u75c7\u7f51\u7edc\uff08NCCN\uff09\u53d1\u5e03\u4e86\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6307\u5357 2019 \u5e74\u7b2c 1 \u7248\uff0c\u9996\u6b21\u5c06\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08TMB\uff09\u5217\u4e3a\u6807\u5fd7\u7269\uff0c\u7b5b\u9009\u9002\u5408\u63a5\u53d7\u7eb3\u6b66\u5229\u5c24\u5355\u6297\uff08Nivolumab\uff09+\u4f0a\u5339\u5355\u6297\uff08Ipilimumab\uff09\u8054\u5408\u6cbb\u7597\uff0c\u6216\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u5355\u836f\u6cbb\u7597\u7684\u80ba\u764c\u60a3\u8005\u3002<\/div>\n
\u2022\u00a0\u8bd5\u9a8c\u7814\u7a76\uff1a\u6839\u636eCheckmate-227\uff0cTMB\u9ad8\uff08\u226510\u4e2a\u7a81\u53d8\/Mb\uff09\u7684NSCLC\u60a3\u8005\uff0c\u7eb3\u6b66\u5229\u5c24\u5355\u6297+\u4f0a\u5339\u5355\u6297\u4e00\u7ebf\u6cbb\u7597\u5c061\u5e74\u65e0\u8fdb\u5c55\u751f\u5b58\u7387\u7ffb\u4e863\u500d\u591a\uff0842.6% vs. 13.2%\uff09\uff1b\u6839\u636eCheckmate-026\uff0c\u5728TMB\u9ad8\uff08\u2265243\u4e2a\u7a81\u53d8\uff09\u7684\u60a3\u8005\u4e2d\uff0c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u7684ORR\uff0847% vs. 28%\uff09\u548cPFS\uff089.7\u6708 vs. 5.8\u6708\uff09\u663e\u8457\u4f18\u4e8e\u5316\u7597\u3002\u8bc1\u5b9eTMB\u53ef\u4ee5\u6709\u6548\u533a\u5206\u83b7\u76ca\u4eba\u7fa4\u3002<\/div>\n
\u2022\u00a0\u9488\u5bf9\u75be\u75c5\uff1a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<\/div>\n
\u62d3\u5c55\u9605\u8bfb<\/div>\n
1\uff09\u764c\u75c7\u6cbb\u7597\u9886\u57df\u4e13\u5bb6\u4e13\u8bbf\uff1a\u6881\u519b<\/a>\u00a0|\u00a0\u6731\u519b<\/a>\u00a0|\u00a0\u9646\u821c<\/a>\u00a0|\u00a0\u5218\u7ea2\u661f\u00a0<\/a>|\u00a0\u738b\u6770\u519b\u00a0|\u00a0<\/a>\u8305\u77db|\u00a0<\/a>\u6768\u864e\u5c71\u00a0<\/a>|<\/a>\u00a0\u6768\u5e73\u00a0|\u00a0<\/a>\u83e0\u841d<\/a><\/div>\n
2\uff09\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08TMB\uff09\u5b9a\u4e49\u4e3a\u6bcf\u767e\u4e07\u78b1\u57fa\u4e2d\u88ab\u68c0\u6d4b\u51fa\u7684\uff0c\u4f53\u7ec6\u80de\u57fa\u56e0\u7f16\u7801\u9519\u8bef\u3001\u78b1\u57fa\u66ff\u6362\u3001\u63d2\u5165\u6216\u7f3a\u5931\u9519\u8bef\u7684\u603b\u6570\u3002\u53ef\u4ee5\u7b80\u5355\u7406\u89e3\u4e3a\u75c5\u4eba\u80bf\u7624\u7ec4\u7ec7\u4e2d\u6709\u591a\u5c11\u4e2a\u57fa\u56e0\u7a81\u53d8\u3002\u76ee\u524dPD-L1\u8868\u8fbe\u3001TMB\u3001\u9519\u914d\u4fee\u590d\u7f3a\u9677\uff08dMMR\uff09\u3001\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\uff08MSI\uff09\u7b49\u90fd\u88ab\u53d1\u73b0\u53ef\u4ee5\u9884\u6d4b\u60a3\u8005\u63a5\u53d7\u514d\u75ab\u6cbb\u7597\u7684\u6709\u6548\u6027\uff0c\u4f46\u662f\u9884\u6d4b\u4f5c\u7528\u6bd4\u8f83\u5c40\u9650\uff0c\u5728\u672a\u6765\uff0c\u5c06TMB\u4e0e\u5176\u4ed6\u7684\u6807\u5fd7\u7269\u8054\u5408\u4f7f\u7528\u53ef\u80fd\u4f1a\u63d0\u5347TMB\u7684\u9884\u6d4b\u80fd\u529b\u3002<\/div>\n
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10\u3001\u7caa\u83cc\u79fb\u690d\u7f13\u89e3\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u5e76\u53d1\u75c7<\/div>\n\n
\n![\"0?wx_fmt=jpeg\"\/](\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/RmFicvQBAkgBUD9OpeSHVpIFFWgsbs3V6DDOgaQibRSia7UiaMssMNsPvt2kkPpC39Dl5TJLRNz7kxe8KS4JqU1ic6w\/0?wx_fmt=jpeg\")
<\/figure><\/div>\n\n<\/div>\n
<\/div>\n
\u2022\u00a0\u4e34\u5e8a\u7a81\u7834\uff1a2018\u5e7411\u670812\u65e5\uff0c\u300aNature Medicine\u300b\u53d1\u8868\u4e00\u4efd\u75c5\u4f8b\u62a5\u544a\uff0c\u5c06\u5065\u5eb7\u4f9b\u8005\u4f53\u5185\u63d0\u53d6\u7684\u5fae\u751f\u7269\u7fa4\u79fb\u690d\u52302\u540d\u764c\u75c7\u60a3\u8005\u4f53\u5185\u540e\uff0c\u56e0\u514d\u75ab\u6cbb\u7597\u5f15\u8d77\u7684\u7ed3\u80a0\u708e\u5f97\u5230\u663e\u8457\u7f13\u89e3\u3002\u9996\u6b21\u8bc1\u5b9e\u79fb\u690d\u7caa\u4fbf\u4e2d\u7684\u80a0\u9053\u5fae\u751f\u7269\u53ef\u4ee5\u6cbb\u7597\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u5f15\u53d1\u7684\u7ed3\u80a0\u708e\u3002<\/div>\n
\u2022\u00a0\u9488\u5bf9\u75be\u75c5\uff1a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u5e76\u53d1\u75c7<\/div>\n
\u2022\u00a0\u4e3b\u8981\u7814\u7a76\u56e2\u961f\uff1aYinghong Wang\u56e2\u961f\uff08MD Anderson\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3\uff09<\/div>\n
\u2022\u00a0\u8bba\u6587\u53d1\u8868\uff1a<\/div>\n
https:\/\/www.nature.com\/articles\/s41591-018-0238-9<\/div>\n
\u62d3\u5c55\u9605\u8bfb<\/div>\n
1\uff09\u5fae\u751f\u7269\u9886\u57df\u4e13\u5bb6\u4e13\u8bbf\uff1a\u6768\u4e91\u751f<\/a> | \u8d75\u7acb\u5e73<\/a>\u00a0| \u674e\u5ef6\u9752<\/a>\u00a0|\u00a0\u79e6\u6960<\/a> | \u6768\u745e\u99a5\u00a0<\/a>|\u00a0\u6587\u6d01<\/a>\u00a0|\u00a0\u9646\u7956\u5b8f\u3001\u84dd\u707f\u8f89\u3001\u8d75\u67cf\u95fb<\/a><\/div>\n
2\uff09\u80a0\u9053\u83cc\u7fa4\u5bf9\u7ef4\u6301\u4eba\u4f53\u5065\u5eb7\u5177\u6709\u91cd\u8981\u4f5c\u7528\uff0c\u80a0\u9053\u5fae\u751f\u6001\u5931\u8861\u4e0e\u708e\u75c7\u6027\u80a0\u75c5\u3001\u4ee3\u8c22\u7efc\u5408\u5f81\u3001\u809d\u75c5\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u5173\u8282\u708e\u3001\u5e15\u91d1\u68ee\u548c\u81ea\u95ed\u75c7\u7b49\u591a\u79cd\u75be\u75c5\u5bc6\u5207\u76f8\u5173\uff0c\u7ea0\u6b63\u80a0\u9053\u5fae\u751f\u6001\u5931\u8861\u6216\u5c06\u6709\u52a9\u4e8e\u8fd9\u4e9b\u75be\u75c5\u7684\u6cbb\u7597\u3002<\/div>\n
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\u00a0 \u300a\u77ad\u671b2020\u300b\u00a0\u00a0<\/div>\n
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\n\n
\n![\"RmFicvQBAkgCGDCRpuRib66NR4ic9qicsQjt6sDcDUcw8Xddxo9ia81ou3lF54gkrZhvLXiacPiblOicbXXu6wyMpP0icMw\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCGDCRpuRib66NR4ic9qicsQjt6sDcDUcw8Xddxo9ia81ou3lF54gkrZhvLXiacPiblOicbXXu6wyMpP0icMw.jpeg\")
<\/figure><\/div>\n\n<\/div>\n
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\u7f16\u8005\uff1aCandice\u00a0 \u6821\u5bf9\uff1aEric\u00a0 \u5ba1\u6838\uff1aMark<\/div>\n
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\n\n
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