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\u00a0<\/div>\n
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\u56fe2\uff0cOxford Nanopore\u6d4b\u5e8f\u5e73\u53f0<\/div>\n
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\u00a0<\/div>\n
Oxford Nanopore\u8fd1\u671f\u53d1\u5e03\u4e86\u7528\u4e8e\u4fbf\u643a\u5f0fMinION\u548c\u53f0\u5f0fGridION\u7684\u6d4b\u5e8f\u82af\u7247\u66f4\u65b0\u2014\u2014Rev D\u7248\u672c\u3002\u65b0\u7248\u6d4b\u5e8f\u82af\u7247\u5ef6\u957f\u4e86\u80fd\u88ab\u7528\u4e8eDNA\u6216RNA\u6d4b\u5e8f\u7684\u65f6\u95f4\uff0c\u5c06\u603bDNA\u6570\u636e\u4ea7\u91cf\u63d0\u5347\u81f3\u9ad8\u8fbe30Gb\u6bcf\u5f20\u82af\u7247\uff0c\u5185\u90e8\u6d4b\u8bd5\u80fd\u591f\u5f97\u523050Gb\u3002\u9ad8\u901a\u91cf\u6d4b\u5e8f\u4eeaPromethION\u4f7f\u7528\u4e0d\u540c\u7684\u6d4b\u5e8f\u82af\u7247\uff0c\u5185\u90e8\u6d4b\u5e8f\u5355\u5f20\u82af\u7247\u6570\u636e\u4ea7\u51fa\u5df2\u8fbe220Gb\u3002\u7528\u6237\u5b9e\u9645\u6d4b\u5e8f\u53cd\u9988\u6700\u9ad8\u6570\u636e\u4ea7\u51fa\u76ee\u524d\u4e3a150Gb\u3002<\/div>\n
\u00a0<\/div>\n
2\u3001\u7eb3\u7c73\u5b54\u6d4b\u5e8f\u7684\u7279\u70b9\u00a0<\/div>\n
1\uff09\u957f\u8bfb\u957f<\/div>\n
\u957f\u8bfb\u957f\u63d0\u4f9b\u4e86\u4e00\u4e2a\u66f4\u660e\u786e\u7684\u65b9\u6cd5\u6765\u6bd4\u5bf9\u548c\u5339\u914dDNA\u6216RNA\u5e8f\u5217\uff0c\u63d0\u4f9b\u9ad8\u8d28\u91cf\u3001\u66f4\u5b8c\u6574\u3001\u66f4\u8fde\u7eed\u7684\u57fa\u56e0\u7ec4\u7ec4\u88c5\u3002\u5728\u7c7b\u5982\u690d\u7269\u57fa\u56e0\u7ec4\u548c\u5177\u6709\u5927\u578b\u7ed3\u6784\u53d8\u5f02\u548c\u9ad8\u6c34\u5e73\u91cd\u590d\u533a\u57df\u7684\u57fa\u56e0\u7ec4\u4e2d\u4f18\u52bf\u663e\u8457\u3002\u5c31\u50cf\u62fc\u56fe\u4e00\u6837\uff0c\u8bfb\u957f\u8d8a\u957f\uff0c\u7ec4\u88c5\u8d8a\u5bb9\u6613\u3002\u5bf9\u4e8eDNA\uff0c\u957f\u8bfb\u957f\u7684\u4f18\u52bf\u5728\u4e8e\u80fd\u591f\u7b80\u5316\u4ece\u5934\u7ec4\u88c5\uff0c\u6539\u8fdb\u53c2\u8003\u57fa\u56e0\u7ec4\uff0c\u8fdb\u884cphasing\uff0c\u4ee5\u53ca\u5feb\u901f\u7684\u5b8f\u57fa\u56e0\u7ec4\u7269\u79cd\u9274\u5b9a\u3002\u5bf9\u4e8eRNA\uff0c\u5b83\u80fd\u591f\u7528\u4e8e\u8868\u5f81\u5168\u957f\u8f6c\u5f55\u672c\uff0c\u4ee5\u53ca\u5bf9\u5f02\u6784\u4f53\u3001\u526a\u63a5\u53d8\u4f53\u548c\u878d\u5408\u8f6c\u5f55\u672c\u8fdb\u884c\u91cf\u5316\u548c\u5206\u6790\u3002<\/div>\n
2\uff09\u76f4\u63a5\u6d4b\u5e8f<\/div>\n
\u7531\u4e8e\u7eb3\u7c73\u5b54\u6280\u672f\u652f\u6301\u5bf9\u539f\u59cbDNA\u548cRNA\u94fe\u76f4\u63a5\u8fdb\u884c\u6d4b\u5e8f\uff0c\u4e0d\u9700\u8981\u901a\u8fc7DNA\u62f7\u8d1d\u3001\u8fdb\u884c\u94fe\u5408\u6210\u6216\u4f7f\u7528\u4e9a\u785d\u9178\u76d0\u8fdb\u884c\u8f6c\u5316\uff0c\u8fd9\u4e0d\u4ec5\u8282\u7701\u4e86\u65f6\u95f4\u548c\u6210\u672c\uff0c\u8fd8\u610f\u5473\u7740\u78b1\u57fa\u4fee\u9970\u7684\u4fe1\u606f\uff08\u4f8b\u59825mC\uff0cpseudouridine\uff0cm6A\uff09\u4f1a\u88ab\u5b8c\u6574\u7684\u4fdd\u7559\uff0c\u5e76\u4e14\u5305\u542b\u5728\u6d4b\u5e8f\u8fd0\u884c\u4ea7\u751f\u7684\u539f\u59cb\u4fe1\u53f7\u4fe1\u606f\u4e2d\uff0c\u968f\u65f6\u8fdb\u884c\u5206\u6790\u3002\u7531\u4e8e\u7eb3\u7c73\u5b54\u6280\u672f\u652f\u6301\u65e0\u9700PCR\u7684\u76f4\u63a5\u6d4b\u5e8f\uff0c\u4e5f\u5c31\u6ca1\u6709\u4e86\u6269\u589e\u504f\u597d\u6027\uff0c\u5e76\u4e14\u6587\u5e93\u5236\u5907\u5de5\u4f5c\u6d41\u7a0b\u4e5f\u66f4\u7b80\u5355\u3002<\/div>\n
3\uff09\u5b9e\u65f6<\/div>\n
\u4e0e\u5728\u8fd0\u884c\u7ed3\u675f\u65f6\u6279\u91cf\u4ea4\u4ed8\u6570\u636e\u7684\u4f20\u7edf\u6d4b\u5e8f\u6280\u672f\u4e0d\u540c\uff0c\u7eb3\u7c73\u5b54\u6280\u672f\u63d0\u4f9b\u7684\u662f\u52a8\u6001\u3001\u5b9e\u65f6\u7684\u6d4b\u5e8f\uff0c\u652f\u6301\u5728\u51e0\u5206\u949f\u5185\u5c31\u83b7\u5f97\u75c5\u539f\u4f53\u9274\u5b9a\u7b49\u65f6\u95f4\u5173\u952e\u578b\u5e94\u7528\u7684\u68c0\u6d4b\u7ed3\u679c\u3002\u7528\u6237\u53ef\u4ee5\u5728\u6d4b\u5e8f\u65e9\u671f\u4e86\u89e3\u6837\u672c\u7684\u8d28\u91cf\u548c\u72b6\u6001\uff0c\u4e5f\u53ef\u4ee5\u5728\u83b7\u5f97\u8db3\u591f\u7684\u6570\u636e\u540e\u505c\u6b62\u6d4b\u5e8f\u3002\u5feb\u901f\u7684\u91c7\u6837\u5230\u7ed3\u679c\u5468\u8f6c\u65f6\u95f4\u5728\u672a\u6765\u611f\u67d3\u6027\u75be\u75c5\u3001\u5b9e\u5730\u52a8\u6001\u76d1\u6d4b\u75ab\u60c5\u7206\u53d1\u4ee5\u53ca\u5176\u5b83\u8bca\u65ad\u65b9\u9762\u5177\u6709\u5de8\u5927\u6f5c\u529b\u3002<\/div>\n
4\uff09\u6309\u9700\u8981\u6d4b\u5e8f<\/div>\n
\u4e0e\u4f20\u7edf\u6d4b\u5e8f\u6280\u672f\u4e0d\u540c\u7684\u662f\uff0c\u5728\u7eb3\u7c73\u5b54\u6d4b\u5e8f\u4e2d\uff0c\u7528\u6237\u53ef\u4ee5\u81ea\u884c\u638c\u63e1\u6d4b\u5e8f\u65f6\u95f4\u3001\u5730\u70b9\u3001\u4ee5\u53ca\u9700\u8981\u4f7f\u7528\u7684\u82af\u7247\u6570\u91cf\u3002\u4f8b\u5982\uff0c\u53ef\u4ee5\u5355\u6b21\u4f7f\u7528\u7684\u6700\u5c0f\u578b\u7684\u6d4b\u5e8f\u82af\u7247Flongle\u9002\u5408\u5feb\u901f\u8d28\u91cf\u68c0\u6d4b\u3001\u5c0f\u578b\u57fa\u56e0\u7ec4\u5b9e\u9a8c\u548c\u9776\u5411\u6d4b\u5e8f\u3002\u4fbf\u643a\u5f0f\u6d4b\u5e8f\u4eeaMinION\uff0c\u91cd\u91cf\u4e0d\u8db3100g\uff0c\u53ef\u4ee5\u88ab\u5e26\u5230\u4efb\u4f55\u5730\u65b9\u6d4b\u5e8f\u4efb\u4f55\u6837\u672c\u3002\u53f0\u5f0f\u6d4b\u5e8f\u4eeaGridION\u548cPromethION\u5206\u522b\u5177\u67095\u4e2a\u548c48\u4e2a\u6d4b\u5e8f\u82af\u7247\uff0c\u6bcf\u4e2a\u82af\u7247\u53ef\u4ee5\u72ec\u7acb\u8fd0\u884c\uff0c\u4e5f\u53ef\u4ee5\u540c\u65f6\u4f7f\u7528\uff0c\u5e76\u7ed3\u5408\u5b9e\u65f6\u7684\u6570\u636e\u4f20\u9001\u3002\u8fd9\u610f\u5473\u7740\u7528\u6237\u53ef\u4ee5\u6839\u636e\u6837\u672c\u7684\u6570\u91cf\u9009\u62e9\u82af\u7247\u6570\u91cf\uff0c\u968f\u6570\u636e\u91cf\u8981\u6c42\u968f\u65f6\u542f\u52a8\u548c\u505c\u6b62\u5b9e\u9a8c\u3002<\/div>\n
5\uff09\u7075\u6d3b\u3001\u53ef\u6269\u5c55<\/div>\n
\u6240\u6709Oxford Nanopore\u6d4b\u5e8f\u8bbe\u5907\u4f7f\u7528\u540c\u6837\u7684\u6838\u5fc3\u6280\u672f\uff0c\u7528\u6237\u53ef\u4ee5\u8f7b\u677e\u6839\u636e\u5e94\u7528\u6d4b\u8bd5\u5b9e\u9a8c\u4ee5\u53ca\u6269\u5927\u6216\u7f29\u5c0f\u89c4\u6a21\u3002\u4ece\u6700\u5c0f\u578b\u7684Flongle\u548c\u638c\u4e0aMinION\uff0c\u5230\u684c\u9762\u578b\u7684GridION\u548cPromethION\u3002\u6240\u6709\u8bbe\u5907\u90fd\u53ef\u7528\u4e8e\u8fdb\u884c\u6309\u9700\u6d4b\u5e8f\u5b9e\u9a8c\u3002\u5305\u62ec\u4ece\u5355\u6b21\u8bd5\u9a8c\u5230\u8d85\u9ad8\u901a\u91cf\u9879\u76ee\uff0c\u5168\u90e8\u90fd\u53ef\u63d0\u4f9b\u5feb\u901f\u3001\u957f\u8bfb\u957f\u3001\u5b9e\u65f6\u7684DNA\u6216RNA\u76f4\u63a5\u6d4b\u5e8f\u3002\u7528\u4e8e\u7eb3\u7c73\u5b54\u6d4b\u5e8f\u7684DNA\u6216RNA\u5efa\u5e93\u8fc7\u7a0b\u7b80\u5355\u76f4\u63a5\uff0c\u6700\u5feb\u7684\u5efa\u5e93\u65b9\u6cd5\u53ea\u97005\u523010\u5206\u949f\u5c31\u53ef\u5728\u6837\u672c\u5206\u5b50\u672b\u7aef\u6dfb\u52a0\u6d4b\u5e8f\u63a5\u5934\u53ca\u9a6c\u8fbe\u86cb\u767d\u3002\u7528\u6237\u53ef\u9009\u62e9\u5236\u59071D\u62161D2\u6587\u5e93\u3002\u57281D\u6d4b\u5e8f\u4e2d\uff0c\u6a21\u677f\u94fe\u548c\u4e92\u8865\u94fe\u5c06\u4f5c\u4e3a\u72ec\u7acb\u5206\u5b50\u8fdb\u884c\u6d4b\u5e8f\u3002\u800c\u57281D2\u6d4b\u5e8f\u4e2d\uff0c\u6dfb\u52a0\u4e86\u4e00\u79cd\u4e0d\u540c\u7684\u63a5\u5934\uff0c\u4f7f\u5f97\u4e92\u8865\u94fe\u53ef\u4ee5\u7d27\u8ddf\u6a21\u677f\u94fe\u901a\u8fc7\u7eb3\u7c73\u5b54\uff0c\u5bf9\u4e24\u6761\u94fe\u8fdb\u884c\u6d4b\u5e8f\uff0c\u8fbe\u5230\u66f4\u9ad8\u7684\u51c6\u786e\u5ea6\u3002<\/div>\n
\u00a0<\/div>\n
\u6240\u6709\u7684\u8bbe\u5907\u5747\u5728\u5b9e\u9a8c\u4e00\u542f\u52a8\u5c31\u5f00\u59cb\u4f20\u8f93\u6570\u636e\uff0c\u5c06\u4fe1\u53f7\u53d8\u5316\u8f6c\u6362\u4e3a\u78b1\u57fa\u5e8f\u5217\u3002\u8fd9\u90fd\u53ef\u4ee5\u5728\u7528\u6237\u7684\u8ba1\u7b97\u673a\u6216Oxford Nanopore\u7684\u673a\u8f7d\u8bbe\u5907\u4e0a\u5728\u672c\u5730\u8fdb\u884c\uff0c\u5b9e\u65f6\u5206\u6790\u610f\u5473\u7740\u53ef\u5373\u65f6\u83b7\u5f97\u4fe1\u606f\uff0c\u4e86\u89e3\u6b63\u5728\u8fdb\u884c\u7684\u6d4b\u5e8f\u4ee5\u53ca\u5b9e\u9a8c\u8d28\u91cf\uff0c\u800c\u65e0\u987b\u7b49\u5f85\u6574\u4e2a\u8fd0\u884c\u7ed3\u675f\u3002\u7528\u6237\u8fd8\u53ef\u5229\u7528EPI2ME\u8bbe\u5907\u63a7\u5236\u8f6f\u4ef6\u6240\u542b\u7684\u5de5\u4f5c\u6d41\u7a0b\u8fdb\u884c\u5b9e\u65f6\u5206\u6790\uff0c\u4ece\u5feb\u901f\u7269\u79cd\u8bc6\u522b\u5230\u4eba\u7c7b\u57fa\u56e0\u7ec4\u5e8f\u5217\u6bd4\u5bf9\uff0c\u4e5f\u53ef\u4ee5\u4f7f\u7528\u81ea\u5df1\u5f00\u53d1\u6216\u6765\u81ea\u7eb3\u7c73\u5b54\u793e\u533a\u7684\u5de5\u4f5c\u6d41\u7a0b\u3002<\/div>\n
\u00a0<\/div>\n
3\u3001\u4ece\u5c0f\u578b\u5b9e\u9a8c\u5ba4\u5230\u5916\u592a\u7a7a\uff0c\u5230\u9ad8\u901a\u91cf\u6d4b\u5e8f\u8bbe\u5907\u00a0<\/div>\n
Oxford Nanopore\u8fd1\u5e74\u6765\u91cd\u8981\u65f6\u95f4\u7ebf\uff1a<\/div>\n\n
\n
\"RmFicvQBAkgBianR1ISAoWwJbHjOzicpfqjIawibxG4l9wpv91d7uVhzUHpGhuJfv1YrXnMNv5FS51SJzswuSsbOjA\"\/<\/figure><\/div>\n\n<\/div>\n
<\/div>\n
\n\n
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\"RmFicvQBAkgDT6TwVtKyB5oPX0xJeTdaV3zukLpARyHkxIlkDFKLJQBaYfyM1qOT2TSOuby6er15QyfoOjXOYzA\"\/<\/figure><\/div>\n\n
\u56fe3\uff0cMinION\u5df2\u7ecf\u5728\u56fd\u9645\u7a7a\u95f4\u7ad9\u4e0a\u6267\u884c\u4e86\u7eb3\u7c73\u5b54DNA\u548c\u76f4\u63a5RNA\u6d4b\u5e8f\u3002\u56fe\u7247\u6765\u6e90\uff1aOxford Nanopore \u6280\u672f\u539f\u7406\u624b\u518c<\/div>\n
2017\u5e74\u5e95\uff0cOxford Nanopore\u7684MinION\u6d4b\u5e8f\u4eea\u6b63\u5f0f\u9762\u5411\u4e2d\u56fd\u7684\u6d88\u8d39\u8005\u53d1\u552e\u3002\u5728\u6700\u521d\u8fdb\u5165\u4e2d\u56fd\u5e02\u573a\u65f6\uff0cOxford Nanopore\u5728\u4e0a\u6d77\u529e\u516c\u5ba4\u6d3e\u9a7b\u6280\u672f\u652f\u6301\u4e13\u5458\u4e3a\u4e2d\u56fd\u4f7f\u7528\u8005\u63d0\u4f9b\u6280\u672f\u670d\u52a1\uff0c\u5e76\u968f\u540e\u5728\u4e2d\u56fd\u6210\u7acb\u4e86\u5206\u516c\u53f8(\u5948\u7c73\u666e\u79d1\u6280\uff08\u4e0a\u6d77\uff09\u6709\u9650\u516c\u53f8)\u3002\u76f8\u6bd4\u8f83\u4e8e\u90a3\u4e9b\u52a8\u8f84\u4e0a\u767e\u4e07\u81f3\u4e0a\u5343\u4e07\u7f8e\u5143\u4e00\u5957\u7684\u5927\u578b\u6d4b\u5e8f\u4eea\u800c\u8a00\uff0cOxford Nanopore\u5e73\u53f0\u7684\u6d88\u8d39\u7ea7\u6d4b\u5e8f\u4eea\u7684\u4ef7\u683c\u771f\u53ef\u8c13\u7f8e\u597d\uff0c\u4e0d\u7ba1\u662f\u5bfb\u5e38\u5b9e\u9a8c\u5ba4\u8fd8\u662f\u5c0f\u578b\u6d4b\u5e8f\u670d\u52a1\u5546\u90fd\u80fd\u914d\u7f6e\u7684\u8d77\uff0c\u884c\u4e1a\u5185\u5f00\u73a9\u7b11\u8bf4\u613f\u610f\u62ffiPhone\u53bb\u6362\u4e00\u53f0MinION\uff0c\u53ef\u89c1\u4ef7\u683c\u4e4b\u4eb2\u6c11\u3002<\/div>\n
\u00a0<\/div>\n
\u968f\u7740\u76f8\u5173\u5316\u5b66\u8bd5\u5242\u7684\u5347\u7ea7\u548c\u7b97\u6cd5\u7684\u4e0d\u65ad\u7a81\u7834\u4e0e\u6539\u8fdb\uff0c\u4ee5\u53ca\u540e\u7eedPromethION\u7684\u53d1\u5e03\uff0cnanopore\u6d4b\u5e8f\u6280\u672f\u7684\u901a\u91cf\u548c\u51c6\u786e\u7387\u90fd\u6709\u5927\u5e45\u63d0\u5347\u3002\u5728\u521a\u521a\u8fc7\u53bb\u768411\u6708\u5e95\u4e3e\u884c\u7684\u7528\u6237\u5927\u4f1a\u4e0a\uff0c\u5176\u9996\u5e2d\u6280\u672f\u5b98Clive Brown\u4ecb\u7ecd\u4e86\u65b0\u7eb3\u7c73\u5b54\u8bbe\u8ba1\u2014\u2014R10\uff0c\u9884\u671f\u57282019\u5e74\u521d\u53d1\u5e03\u3002\u76f8\u8f83\u4e8e\u5f53\u524d\u7684\u7eb3\u7c73\u5b54\u7248\u672c\uff08R9\uff09\uff0cR10\u7248\u7eb3\u7c73\u5b54\u7684\u201c\u6876\u8eab\u201d\u66f4\u957f\uff0c\u5177\u6709\u4e24\u5bf9Reader heads\uff0c\u610f\u5473\u7740\u66f4\u591a\u7684\u78b1\u57fa\u4fe1\u53f7\u6765\u786e\u4fdd\u66f4\u9ad8\u7684\u51c6\u786e\u5ea6\uff0c\u5c24\u5176\u662f\u5728\u5747\u805a\u7269\uff08\u7531\u4e00\u79cd\u5355\u4f53\u805a\u5408\u6210\u7684\uff09\u533a\u57df\u3002\u5728\u6d4b\u5e8f\u4e2d\uff0c\u8d28\u91cf\u503cQ\u662f\u8861\u91cf\u6d4b\u5e8f\u8d28\u91cf\u7684\u91cd\u8981\u6307\u6807\uff0cQ\u503c\u8d8a\u9ad8\uff0c\u4ee3\u8868\u78b1\u57fa\u88ab\u6d4b\u9519\u7684\u6982\u7387(P)\u8d8a\u5c0f\u3002\u5728\u516c\u53f8\u5185\u90e8\u6d4b\u8bd5\u4e2d\uff0c\u4ee575\u500d\u7684\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u8986\u76d6\u5ea6\uff0c\u65b0\u7684R10\u7eb3\u7c73\u5b54\u6570\u636e\u8d28\u91cf\u503c\u8d85\u8fc7Q40\uff08\u5373\u9519\u8bef\u8bc6\u522b\u7684\u6982\u7387\u662f0.01%\uff0c\u5373\u9519\u8bef\u73870.01%\uff09\uff0c\u4e00\u81f4\u6027\uff08Identity\uff09\u8d28\u91cf\u503c\u8fbeQ50 (99.999%\u7684\u78b1\u57fa\u51c6\u786e\u7387)\u3002<\/div>\n\n
\n
\"RmFicvQBAkgDT6TwVtKyB5oPX0xJeTdaVUBics3cgwkiaDKxicCUwibt4icmlguSOw8zwj8zZfqLnRuISs4fH3xgjYrg\"\/<\/figure><\/div>\n\n
Oxford Nanopore Technologies\u516c\u53f8CEO Dr. Gordon Sanghera<\/div>\n
\u201c\u6211\u4eec\u7684\u76ee\u6807\u662f\u8ba9\u4efb\u4f55\u4eba\u90fd\u80fd\u5728\u4efb\u4f55\u73af\u5883\u4e0b\u5206\u6790\u4efb\u4f55\u751f\u7269\u3002\u6211\u4eec\u7684\u6280\u672f\u5df2\u7ecf\u5f97\u5230\u4e86\u5e7f\u6cdb\u7684\u5e94\u7528\uff0c\u9664\u4e86\u7528\u4e8e\u5bfb\u627e\u75c5\u539f\u4f53\u79cd\u7c7b\u76d1\u63a7\u75c5\u6e90\u2014\u2014\u6bd4\u5982\u8ffd\u8e2a\u57c3\u535a\u62c9\u75c5\u6bd2\u7b49\uff0c\u4e5f\u88ab\u5e94\u7528\u4e8e\u519c\u4e1a\u548c\u6559\u80b2\u65b9\u9762\uff0c\u4e3b\u8981\u9488\u5bf9\u9057\u4f20\u5b66\u548c\u751f\u547d\u5065\u5eb7\u65b9\u9762\u3002\u5927\u5bb6\u90fd\u5f88\u719f\u6089\u7269\u8054\u7f51\uff08Internet of Things\uff09\u7684\u6982\u5ff5\uff0c\u5b83\u8bf4\u7684\u662f\u6240\u6709\u7684\u4e8b\u7269\u90fd\u80fd\u88ab\u4e92\u8054\u7f51\u8054\u7cfb\u5728\u4e00\u8d77\uff0c\u5e76\u80fd\u591f\u901a\u8fc7\u4f60\u7684\u667a\u80fd\u624b\u673a\u63a7\u5236\u3002\u6240\u6709\u751f\u7269\u90fd\u6709DNA\uff0c\u6211\u4eec\u53ef\u80fd\u4f1a\u597d\u5947\u5b83\u4eec\u662f\u4ec0\u4e48\u7c7b\u578b\u7684DNA\uff0c\u662f\u5426\u5728\u53d1\u751f\u53d8\u5316\u3001\u662f\u5426\u5065\u5eb7\u7b49\u7b49\u3002\u4f60\u53ef\u4ee5\u8bbe\u60f3\u201c\u751f\u7269\u7269\u8054\u7f51\u201d\uff08Internet of Living Things\uff09\u8fd9\u6837\u7684\u4e00\u4e2a\u6982\u5ff5\uff0c\u5373\u6211\u4eec\u53ef\u4ee5\u5bf9DNA\u8fdb\u884c\u5b9e\u65f6\u6d4b\u5e8f\uff0c\u5e76\u5f97\u5230\u5373\u65f6\u7684\u7ed3\u679c\u53cd\u9988\u3002\u6211\u4eec\u662f\u5168\u7403\u552f\u4e00\u4e00\u5bb6\u80fd\u591f\u505a\u5230\u63d0\u4f9b\u52a8\u6001\u5b9e\u65f6\u7ed3\u679c\u3001\u8fdb\u884c\u6709\u6210\u672c\u6548\u76ca\u3001\u6309\u7528\u6237\u9700\u8981\u6269\u5927\u6216\u7f29\u5c0f\u89c4\u6a21\u6d4b\u5e8f\u7684\u516c\u53f8\u3002\u4f8b\u5982\uff0c\u73b0\u5728\u5c31\u6709\u4e00\u79cd\u75c5\u6bd2\u6b63\u5728\u653b\u51fb\u5728\u975e\u6d32\u548c\u5176\u5b83\u4e00\u4e9b\u56fd\u5bb6\u90fd\u5f88\u53d7\u6b22\u8fce\u7684\u6728\u85af\u4f5c\u7269\u3002\u79d1\u5b66\u5bb6\u4eec\u5c31\u5728\u5b9e\u5730\u5229\u7528MinION\u9274\u5b9a\u75c5\u6bd2\u79cd\u7c7b\uff0c\u7814\u7a76\u63d0\u9ad8\u4f5c\u7269\u4ea7\u91cf\u7684\u6218\u7565\u6027\u63aa\u65bd\u3002\u5982\u679c\u62e5\u6709\u5b9e\u65f6\u7684DNA\u4fe1\u606f\uff0c\u5c31\u53ef\u4ee5\u5b9e\u73b0\u201c\u751f\u7269\u7269\u8054\u7f51\u201d\uff08Internet of Living Things\uff09\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u516c\u53f8\u7684\u76ee\u6807\u5c31\u662f\u8ba9\u4efb\u4f55\u4eba\u3001\u5728\u4efb\u4f55\u5730\u65b9\u90fd\u53ef\u4ee5\u83b7\u53d6DNA\u4fe1\u606f\u3002\u201d<\/div>\n
\u00a0<\/div>\n
4\u3001\u7eb3\u7c73\u5b54\u6d4b\u5e8f\u7684\u5e94\u7528\u9886\u57df\u00a0<\/div>\n\n
\n
\"RmFicvQBAkgDT6TwVtKyB5oPX0xJeTdaVhKekoDJyVhXhzQC63gFzRPDHicpNYQpiasyHKjAoyTbagxEwgxGFTJsw\"\/<\/figure><\/div>\n\n
\u56fe4\uff0c\u7eb3\u7c73\u5b54\u6d4b\u5e8f\u7684\u5e94\u7528\u9886\u57df\uff0c\u56fe\u7247\u6765\u6e90\uff1aOxford Nanopore \u6280\u672f\u539f\u7406\u624b\u518c<\/div>\n
\u5728\u5e94\u7528\u65b9\u9762\uff0cNanopore\u6d4b\u5e8f\u76ee\u524d\u5c1a\u4ec5\u4f9b\u7814\u7a76\u4f7f\u7528\u3002\u9664\u4e86\u76ee\u524d\u79d1\u7814\u5e02\u573a\u706b\u70ed\u7684\u57fa\u56e0\u7ec4\u5e94\u7528\uff0c\u5982\u53d6\u8bc1\u5de5\u4f5c\u3001\u6c34\u8d28\u68c0\u6d4b\u3001\u751f\u7269\u9632\u5fa1\u3001\u75ab\u60c5\u7206\u53d1\u8c03\u67e5\u548c\u76d1\u63a7\u3001\u98df\u54c1\u5b89\u5168\u7b49\uff0c\u4f7f\u7528nanopore\u6d4b\u5e8f\u7684\u79d1\u5b66\u5bb6\u4eec\u8fd8\u5728\u4e0d\u65ad\u62d3\u5bbd\u533b\u5b66\u548c\u751f\u7269\u5b66\u5e94\u7528\u9886\u57df\uff0c\u5982\u5728\u80bf\u7624\u6216\u9057\u4f20\u75c5DNA\u7684\u5206\u6790\u4e2d\u9ad8\u5206\u8fa8\u7387\u7684\u7ed3\u6784\u53d8\u5f02\u5206\u6790\uff1b\u5728\u751f\u6b96\u533b\u7597\u7814\u7a76\u4e2d\uff0c\u6709\u6f5c\u529b\u5e94\u7528\u4e8e\u80da\u80ce\u690d\u5165\u524d\u9057\u4f20\u5b66\u7b5b\u67e5(PGS)\u6216\u80da\u80ce\u690d\u5165\u524d\u57fa\u56e0\u8bca\u65ad(PGD)\uff0c\u68c0\u6d4b\u67d3\u8272\u4f53\u6570\u76ee\u7578\u53d8\u53ca\u589e\u52a0\u7684\u6f5c\u5728\u98ce\u9669\u3002\u8fd8\u53ef\u5e94\u7528\u4e8e\u690d\u7269\u57fa\u56e0\u7ec4\u4ee5\u53ca\u5927\u89c4\u6a21\u4eba\u7fa4\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u9879\u76ee\u3002<\/div>\n
\u6b63\u5982\u5f88\u591a\u5b66\u8005\u6240\u8bf4\uff0c\u201c\u65b0\u4e00\u4ee3\u6d4b\u5e8f\u6280\u672f\u7684\u51fa\u73b0\u7167\u4eae\u4e86\u8fc7\u53bb\u4ece\u672a\u770b\u5230\u7684\u57fa\u56e0\u7ec4\u7684\u9ed1\u6697\u89d2\u843d\u201d\u3002<\/div>\n
\u53c2\u8003\u8d44\u6599\uff1a<\/div>\n
1. \u300a\u57fa\u56e0\u7ec4\u5b66\u300b\uff08\u6768\u7115\u660e\u7f16\u8457\uff09<\/div>\n
2. \u300a\u9ad8\u901a\u91cf\u6d4b\u5e8f\u6280\u672f\u300b\uff08\u674e\u91d1\u660e\u4e3b\u7f16\uff09<\/div>\n
3.\u00a0 Oxford Nanopore Technologies \u5b98\u65b9\u7f51\u7ad9\uff0c\u8bbf\u95ee\u65f6\u95f42018\u5e7412\u670827\u65e5\u3002https:\/\/nanoporetech.com\/<\/div>\n
\u00a0<\/div>\n
\u7f16\u8005\uff1aClare\u00a0 \u6821\u5bf9\uff1aEric\u00a0 \u5ba1\u6838\uff1aMark<\/div>\n\n
\n
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