{"id":9327,"date":"2019-01-03T22:15:45","date_gmt":"2019-01-03T14:15:45","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&mid=100009097&idx=1&sn=28922deec01a8f7f2898c8ec4bad12fc&chksm=6b71563e5c06df28749cf69e8ee037b767dcd1a94d63102f565c1d9111ea650908f2e9f59d1b#rd"},"modified":"2026-04-02T14:42:05","modified_gmt":"2026-04-02T06:42:05","slug":"569998","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2019\/01\/03\/569998\/","title":{"rendered":"2019\u5e74\u7b2c\u4e00\u7b14\u91cd\u78c5\u4ea4\u6613\uff1a740\u4ebf\u7f8e\u5143\uff0cBMS\u5ba3\u5e03\u6536\u8d2dCelgene | GeneMail\u5468\u62a5"},"content":{"rendered":"

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\u6587\/\u57fa\u56e0\u6167<\/div>\n
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\"?wx_fmt=jpeg\"\/<\/figure><\/div>\n\n
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2019\u5e741\u67083\u65e5\uff0c\u56fd\u52a1\u9662\u529e\u516c\u5385\u53d1\u5e03\u300a\u5173\u4e8e\u6293\u597d\u8d4b\u4e88\u79d1\u7814\u673a\u6784\u548c\u4eba\u5458\u66f4\u5927\u81ea\u4e3b\u6743\u6709\u5173\u6587\u4ef6\u8d2f\u5f7b\u843d\u5b9e\u5de5\u4f5c\u7684\u901a\u77e5\u300b\uff0c\u6df1\u5165\u63a8\u8fdb\u4e0b\u653e\u79d1\u6280\u7ba1\u7406\u6743\u9650\u5de5\u4f5c\u5e76\u8fdb\u4e00\u6b65\u505a\u597d\u5df2\u51fa\u53f0\u6cd5\u89c4\u6587\u4ef6\u4e2d\u76f8\u5173\u89c4\u5b9a\u7684\u8854\u63a5\uff0c\u5c06\u52a0\u5f3a\u5bf9\u653f\u7b56\u8d2f\u5f7b\u843d\u5b9e\u5de5\u4f5c\u7684\u7763\u67e5\u6307\u5bfc\u3002<\/div>\n
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2018\u5e7412\u670828\u65e5\uff0c\u4e3a\u5f15\u5bfc\u79d1\u6280\u4f01\u4e1a\u5b75\u5316\u5668\u9ad8\u8d28\u91cf\u53d1\u5c55\uff0c\u79d1\u6280\u90e8\u53d1\u5e03\u300a\u79d1\u6280\u4f01\u4e1a\u5b75\u5316\u5668\u7ba1\u7406\u529e\u6cd5\u300b\uff0c\u660e\u786e\u4e86\u56fd\u5bb6\u7ea7\u79d1\u6280\u4f01\u4e1a\u5b75\u5316\u5668\u7684\u7533\u8bf7\u6761\u4ef6\u53ca\u7533\u62a5\u7a0b\u5e8f\uff0c\u5f3a\u8c03\u5e94\u5f62\u6210\u201c\u4f17\u521b\u2014\u5b75\u5316\u2014\u52a0\u901f\u201d\u673a\u5236\uff0c\u63d0\u4f9b\u5168\u5468\u671f\u521b\u4e1a\u670d\u52a1\uff0c\u652f\u6301\u6709\u6761\u4ef6\u7684\u9f99\u5934\u4f01\u4e1a\u3001\u79d1\u7814\u9662\u6240\u3001\u6295\u8d44\u673a\u6784\u7b49\u5efa\u8bbe\u4e13\u4e1a\u5b75\u5316\u5668\u3002<\/div>\n
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2018\u5e7412\u670829\u65e5\uff0c\u56fd\u5bb6\u536b\u5065\u59d4\u3001\u53d1\u6539\u59d4\u3001\u533b\u4fdd\u5c40\u7b49\u5341\u4e8c\u90e8\u95e8\u5370\u53d1\u300a\u5173\u4e8e\u52a0\u5feb\u843d\u5b9e\u4eff\u5236\u836f\u4f9b\u5e94\u4fdd\u969c\u53ca\u4f7f\u7528\u653f\u7b56\u5de5\u4f5c\u65b9\u6848\u300b\uff0c\u660e\u786e2019\u5e746\u6708\u5e95\u524d\u5c06\u53d1\u5e03\u7b2c\u4e00\u6279\u9f13\u52b1\u4eff\u5236\u7684\u836f\u54c1\u76ee\u5f55\uff0c\u5f15\u5bfc\u4f01\u4e1a\u7814\u53d1\u3001\u6ce8\u518c\u548c\u751f\u4ea7\uff1b\u63d0\u9ad8\u4e0a\u5e02\u836f\u54c1\u8d28\u91cf\uff0c\u5b8c\u5584\u77e5\u8bc6\u4ea7\u6743\u4fdd\u62a4\uff0c\u4fc3\u8fdb\u4eff\u5236\u836f\u66ff\u4ee3\u4f7f\u7528\u3002<\/div>\n
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\"RmFicvQBAkgAJ5ygw8CulTb8GZwSBG1icSycWlbh3FicmgO83x8jIfwjQxVfWCIT2AqD4pIS9MMzTP2ribY2jgDX5Q\"\/<\/figure><\/div>\n\n
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1\u67082\u65e5\uff0c\u65e5\u672c\u4eac\u90fd\u5927\u5b66\u7814\u7a76\u4eba\u5458\u5728\u300aNature\u300b\u53d1\u6587\uff0c\u8bc1\u5b9e\u751f\u7406\u5b66\u7279\u5f81\u6b63\u5e38\u7684\u98df\u7ba1\u7ec6\u80de\u5185\u4e5f\u4f1a\u5b58\u5728\u764c\u75c7\u57fa\u56e0\u7a81\u53d8\uff0c\u5e76\u968f\u7740\u5e74\u9f84\u589e\u957f\u800c\u79ef\u805a\u3002\u5305\u62ec\u996e\u9152\u548c\u5438\u70df\u5728\u5185\u7684\u98ce\u9669\u56e0\u5b50\u4f1a\u4fc3\u4f7f\u7a81\u53d8\u589e\u591a\uff0c\u5c24\u5176\u662f\u764c\u76f8\u5173\u57fa\u56e0NOTCH1\u7684\u7a81\u53d8\uff0c\u996e\u9152\u548c\u5438\u70df\u5bf9\u98df\u7ba1\u764c\u7684\u53d1\u751f\u53d1\u5c55\u5177\u6709\u91cd\u8981\u5f71\u54cd\u3002<\/div>\n
\u00a0<\/div>\n
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12\u670831\u65e5\uff0c\u79d1\u5b66\u5bb6\u5bf9\u82f1\u56fd\u751f\u7269\u6837\u672c\u5e93\u4e2d\u8d85\u8fc742.6\u4e07\u4eba\u8fdb\u884c\u7814\u7a76\u540e\u6210\u529f\u7ed8\u5236\u4e0e\u4f30\u7b97\u9aa8\u5bc6\u5ea6\u76f8\u5173\u7684\u9057\u4f20\u56fe\u8c31\uff0c\u53d1\u8868\u5728\u300aNature Genetics\u300b\uff0c\u9aa8\u5bc6\u5ea6\u662f\u8bca\u65ad\u9aa8\u8d28\u758f\u677e\u75c7\u76f8\u5173\u56e0\u5b50\u4e4b\u4e00\u3002\u79d1\u5b66\u5bb6\u9274\u5b9a\u51fa518\u4e2a\u57fa\u56e0\u7ec4\u4f4d\u70b9\uff0c\u65b0\u53d1\u73b0301\u4e2a\u4f4d\u70b9\uff0c\u6709\u671b\u4f5c\u4e3a\u7814\u53d1\u9aa8\u8d28\u758f\u677e\u75c7\u65b0\u836f\u7684\u9776\u70b9\u3002<\/div>\n
\u00a0<\/div>\n
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12\u670831\u65e5\u300aNature\u300b\u5b50\u520a\u300aNature Cell Biology\u300b\u53d1\u8868\u745e\u58eb\u79d1\u5b66\u5bb6\u7684\u6700\u65b0\u7814\u7a76\uff0c\u901a\u8fc7\u4e73\u817a\u764c\u6a21\u578b\u5c0f\u9f20\u8bd5\u9a8c\u53d1\u73b0\u4e24\u79cd\u5e38\u89c1\u5316\u7597\u836f\u7269\u7d2b\u6749\u9187\u548c\u963f\u9709\u7d20\u4f1a\u8bf1\u5bfc\u4e73\u817a\u80bf\u7624\u7ec6\u80de\u91ca\u653e\u51fa\u5916\u6ccc\u4f53\uff0c\u7ecf\u8840\u6db2\u5faa\u73af\u5230\u8fbe\u80ba\u90e8\u91ca\u653eannexin-A6\uff0c\u8fdb\u4e00\u6b65\u5438\u5f15\u5355\u6838\u7ec6\u80de\u4fc3\u8fdb\u764c\u7ec6\u80de\u751f\u957f\u3002<\/div>\n
\u00a0<\/div>\n
\u4ea7\u4e1a<\/div>\n\n
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\"?wx_fmt=png\"\/<\/figure><\/div>\n\n
BMS\u5ba3\u5e03740\u4ebf\u7f8e\u5143\u6536\u8d2dCelgene<\/div>\n
2019\u5e741\u67083\u65e5\u665a\u95f4\uff0c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff08BMS\uff09\u5ba3\u5e03\u5c06\u4ee5\u73b0\u91d1\u548c\u80a1\u7968\u4f5c\u4ef7\u5408\u8ba1740\u4ebf\u7f8e\u5143\u6536\u8d2d\u65b0\u57fa\uff08Celgene\uff09\uff0c\u8fd9\u662f2019\u5e74\u751f\u547d\u5065\u5eb7\u9886\u57df\u7b2c\u4e00\u7b14\u91cd\u78c5\u4ea4\u6613\u3002\u4ea4\u6613\u9884\u8ba1\u57282019\u5e74\u7b2c\u4e09\u5b63\u5ea6\u5b8c\u6210\uff0cBMS\u80a1\u4e1c\u9884\u8ba1\u6301\u6709\u65b0\u516c\u53f8\u7ea669%\u7684\u80a1\u4efd\uff0cCelgene\u80a1\u4e1c\u9884\u8ba1\u6301\u6709\u8fd131%\u80a1\u4efd\u3002\u521b\u65b0\u836f\u516c\u53f8Celgene\u57282018\u5e74\u5e74\u521d\u65a5\u8d4490\u4ebf\u7f8e\u5143\u6536\u8d2dJuno\uff0c\u6210\u4e3aCAR-T\u7597\u6cd5\u9886\u519b\u4f01\u4e1a\u3002BMS\u5750\u62e5\u5168\u7403\u9996\u4e2a\u4e0a\u5e02\u7684PD-1\u5355\u6297Opdivo\uff0c\u4ee5\u53caOpdivo+Yervoy\u514d\u75ab\u7ec4\u5408\u7597\u6cd5\uff0c\u8be5\u7b14\u6536\u8d2d\u8fd8\u5c06\u4e3a\u5176\u4ea7\u54c1\u7ebf\u6dfb\u52a0\u91cd\u78c5\u6297\u764c\u836fRevlimid\uff0c\u8fdb\u4e00\u6b65\u5de9\u56faBMS\u5728\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9886\u57df\u7684\u9886\u5148\u5730\u4f4d\u548c\u5b9e\u529b\u3002BMS\u5c06\u6253\u9020\u4e00\u5bb6\u751f\u7269\u5236\u836f\u5de8\u5934\uff0c\u5728\u764c\u75c7\u3001\u514d\u75ab\u75be\u75c5\u53ca\u5fc3\u8840\u7ba1\u75be\u75c5\u7b49\u9886\u57df\u5e26\u6765\u66f4\u591a\u91cd\u78c5\u521b\u65b0\u836f\u3002<\/div>\n
\u00a0<\/div>\n
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2019\u5e741\u67082\u65e5\uff0c\u5955\u5b89\u6d4e\u4e16\u751f\u7269\u836f\u4e1a (HJB) \u548c\u8fc8\u535a\u65af\u751f\u7269 (MabSpace) \u5ba3\u5e03\u5408\u5e76\uff0c\u6210\u7acbTranscenta Holding (Transcenta)\uff0c\u65b0\u516c\u53f8\u5c06\u5177\u5907\u751f\u7269\u836f\u7269\u7814\u7a76\u3001\u5f00\u53d1\u3001\u6cd5\u89c4\u548c\u751f\u4ea7\u7684\u5168\u6d41\u7a0b\u6574\u5408\u80fd\u529b\u3002\u5955\u5b89\u6d4e\u4e16\u5171\u540c\u521b\u59cb\u4eba\u517c\u9996\u5e2d\u6267\u884c\u5b98\u8d75\u5955\u5b81\u535a\u58eb\u5c06\u62c5\u4efbTranscenta\u6267\u884c\u8463\u4e8b\u957f\u3002<\/div>\n
\u00a0<\/div>\n
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2018\u5e7412\u670830\u65e5\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u516c\u53f8TCR2 Therapeutics\u5df2\u5411\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\u9012\u4ea4\u4e86IPO\u7533\u8bf7\uff0c\u62df\u52df\u8d441\u4ebf\u7f8e\u5143\uff0c\u5176TCR\u7597\u6cd5\u6709\u671b\u5bf9\u5b9e\u4f53\u7624\u5e26\u6765\u7597\u6548\uff1bHarpoon Therapeutics\u5df2\u4e8e12\u670827\u65e5\u63d0\u4ea4IPO\u7533\u8bf7\uff0c\u62df\u52df\u8d448625\u4e07\u7f8e\u5143\u3002<\/div>\n
\u00a0<\/div>\n
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2018\u5e7412\u670828\u65e5\uff0c\u4e13\u6ce8\u4e8e\u7814\u53d1\u7ebf\u7c92\u4f53\u75c5\u7597\u6cd5\u7684\u9886\u5148\u4f01\u4e1aStealth Bio Therapeutics\u5ba3\u5e03\u5411\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\u9012\u4ea4IPO\u7533\u8bf7\uff0c\u62df\u52df\u96c68600\u4e07\u7f8e\u5143\uff0c\u7528\u4e8e\u7814\u53d1\u4e0e\u7ebf\u7c92\u4f53\u529f\u80fd\u5931\u8c03\u76f8\u5173\u75be\u75c5\u7684\u65b0\u578b\u9996\u521b\u7597\u6cd5\u5e76\u5c06\u5176\u5546\u4e1a\u5316\u3002<\/div>\n
\u00a0<\/div>\n
\u878d\u8d44<\/div>\n\n
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