{"id":9301,"date":"2019-03-15T12:45:14","date_gmt":"2019-03-15T04:45:14","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&#038;mid=100009791&#038;idx=1&#038;sn=021343748d28f0751b71720b1d6e5fd7&#038;chksm=6b7155885c06dc9ea06b62a6c86f0bb16b592164a7894ce3bf81b0052d45a966fe975daec0a9#rd"},"modified":"2026-04-08T10:28:45","modified_gmt":"2026-04-08T02:28:45","slug":"545053","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2019\/03\/15\/545053\/","title":{"rendered":"\u89e3\u4e34\u5e8a\u533b\u751f\u4e4b\u75db\uff1aLDT\u7ea7\u522b\u7684\u5b9a\u5236\u5316panel\u6848\u4f8b\u4ee5\u53ca\u65b9\u6848\u5206\u6790"},"content":{"rendered":"<p><!-- wechat_content_hash: 625876ea51133ee7 --><\/p>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCuC54K47siaoibvbClYbpoQdmoEA7Yo9T0l4l5c9wsK8DWv13zXvBYojNDUX4HpbxOEe8enSicCuVVg.gif\" alt=\"RmFicvQBAkgCuC54K47siaoibvbClYbpoQdmoEA7Yo9T0l4l5c9wsK8DWv13zXvBYojNDUX4HpbxOEe8enSicCuVVg\"\/><\/figure><\/div>\n\n<div>\u5173\u952e\u8bcd\/\u57fa\u56e0Panel \u6587\/\u57fa\u56e0\u6167<\/div>\n<div>\u6211\u56fd\u662f\u80bf\u7624\u53d1\u75c5\u5927\u56fd\uff0c\u6bcf\u5e74\u7ea6400\u4e07\u7684\u65b0\u53d1\u75c5\u4f8b\uff0c\u7ea6\u5360\u5168\u74031\/5\u3002\u73b0\u5df2\u660e\u786e\u80bf\u7624\u662f\u4e00\u79cd\u57fa\u56e0\u7ec4\u75c5\uff0c\u57fa\u56e0\u8bca\u65ad\u4e0e\u7cbe\u51c6\u6cbb\u7597\u5c24\u4e3a\u91cd\u8981\u3002NGS panel\uff08\u57fa\u56e0\u7ec4\u5408\uff09\u662f\u8bc4\u4f30\u57fa\u56e0\u6c34\u5e73\u53d8\u5f02\u7684\u4e3b\u8981\u65b9\u5f0f\uff0c\u4f46\u5728\u5b9e\u9645\u4e34\u5e8a\u5e94\u7528\u65f6\uff0c\u533b\u751f\u5f80\u5f80\u6709\u66f4\u591a\u6837\u5316\u548c\u4e2a\u6027\u5316\u7684\u9700\u6c42\u3002\u672c\u6587\u5c06\u4e3b\u8981\u4ecb\u7ecd\u5b9a\u5236\u5316\u57fa\u56e0Panel\u5982\u4f55\u4e3a\u4e34\u5e8a\u533b\u751f\u89e3\u51b3\u75db\u70b9\uff0c\u66f4\u6709\u4e13\u4e1a\u5de1\u8bb2\u4f1a\u9080\u60a8\u53c2\u4e0e\u3002<\/div>\n<div>\u00a0<\/div>\n<div>1\u3001NGS Panel\u4f5c\u4e3a\u91cd\u8981\u7684\u80bf\u7624\u5206\u5b50\u6807\u8bb0\u7269\u53ef\u884c\u6027\u68c0\u6d4b\u65b9\u5f0f<\/div>\n<div>\u7f8e\u56fd\u56fd\u5bb6\u7efc\u5408\u764c\u75c7\u7f51\u7edc\uff08NCCN\uff09\u53d1\u5e03\u4e86\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6307\u5357 2019 \u5e74\u7b2c 1 \u7248\u53d1\u5e03\u5f15\u8d77\u8f83\u5927\u53cd\u54cd\uff0c\u9996\u6b21\u5c06TMB\uff08Tumor Mutation Burden\uff0c\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff09\u5199\u5165\u4e86\u6307\u5357[1]\u3002<\/div>\n<div>\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08tumor mutational burden\uff0cTMB\uff09\u662f\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08\u5305\u62ecPD-1\/PD-L1\u5355\u6297\u7b49\uff09\u7684\u4e3b\u8981\u7597\u6548\u9884\u6d4b\u6307\u6807\u4e4b\u4e00\u3002\u5168\u5916\u663e\u5b50\u7ec4\uff08whole exome sequncing, WES\uff09\u6d4b\u5e8f\u68c0\u6d4bTMB\u6210\u672c\u4ecd\u7136\u8f83\u9ad8\u60c5\u51b5\u4e0b\uff0c\u57fa\u4e8e\u4e8c\u4ee3\u6d4b\u5e8f\u6280\u672f\u7684\u57fa\u56e0\u7ec4\u5408\uff08NGS panel\uff09\u6765\u8bc4\u4f30TMB\u662f\u4e34\u5e8a\u5e38\u89c1\u7684\u53ef\u64cd\u4f5c\u65b9\u5f0f\u3002<\/div>\n<div>\u00a0<\/div>\n<div>1\uff09Foundation Medicine\u7684ZacharyR. 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NCCN GuidelinesVersion 1.2019 Non-Small Cell Lung Cancer<\/div>\n<div>2. Zachary R. Chalmers et al, Analysisof 100,000 human cancer genomes reveals the landscape of tumor mutationalburden, Genome Medicine 2017 9:34<\/div>\n<div>3. Keiichi HATAKEYAMAet al, Tumor mutational burden analysis of 2,000 Japanese cancer genomes usingwhole exome and targeted gene panel sequencing, Biomedical Research 2018 39(3):159-167<\/div>\n<div>4. Zhijie Wang et al, Assessmentof Blood Tumor Mutational Burden as a Potential Biomarker for Immunotherapy inPatients With Non\u2013Small Cell Lung Cancer With Use of a Next-GenerationSequencing Cancer Gene Panel,JAMA Oncol. 2019. doi:10.1001\/jamaoncol.2018.7098<\/div>\n<div>5. \u516c\u4f17\u53f7\u201c\u80bf\u7624\u8d44\u8baf\u201d\u300a\u3010JAMA Oncology\u3011 \u56fd\u9645\u80bf\u7624\u5b66\u671f\u520a\u4e0a\u7684\u4e2d\u56fd\u539f\u521b\u58f0\u97f3\u300b<\/div>\n<div>\u00a0<\/div>\n<div><\/div>\n<div>\u00a0\u00a0\u7f16\u8005\uff1a\u5e03\u4e09\u5c11\u00a0 \u00a0\u6821\u5bf9\uff1aEric\/Cindy\u00a0 \u5ba1\u6838\uff1aMark<\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<div>\u76f8\u5173\u9605\u8bfb<\/div>\n<div><\/div>\n<div><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247492677&amp;idx=1&amp;sn=3b1469b5f358e047fd9ac316b32e33eb&amp;chksm=eb7156f2dc06dfe42076f6d9d70412ef2bdcd65836aa4f2666d6131270a57724b9786d430121&amp;scene=21#wechat_redirect\" \/>\u57fa\u56e0\u68c0\u6d4b\u5982\u4f55\u7ed9\u80bf\u7624\u60a3\u8005\u5e26\u6765\u5e0c\u671b\uff1f<\/a><\/div>\n<div><\/div>\n<div><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247492677&amp;idx=1&amp;sn=3b1469b5f358e047fd9ac316b32e33eb&amp;chksm=eb7156f2dc06dfe42076f6d9d70412ef2bdcd65836aa4f2666d6131270a57724b9786d430121&amp;scene=21#wechat_redirect\" \/><\/p>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/RmFicvQBAkgDmAdyl4ic1nfL7vH2czfknWibssakQic6p7027RAIKy0iaFPDiaKhCIzqpwazkfp02AmRRM1IfX38ibXwQ\/?wx_fmt=jpeg\" alt=\"?wx_fmt=jpeg\"\/><\/figure><\/div>\n\n<p><\/a><\/div>\n<div><\/div>\n<div><\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDJkslCjQ2eianQraykAic9cibUichkIGia8EuLp3BVEkck3PVXluOAXw8KiciaicupVhsldIek3LTFOgChcg.png\" alt=\"RmFicvQBAkgDJkslCjQ2eianQraykAic9cibUichkIGia8EuLp3BVEkck3PVXluOAXw8KiciaicupVhsldIek3LTFOgChcg\"\/><\/figure><\/div>\n\n<div>\u65b0\u5a92\u4f53\u7f16\u8f91<\/div>\n<div>\u884c\u4e1a\u5206\u6790\u5e08<\/div>\n<div>CEO\u52a9\u7406<\/div>\n<div>\u7b80\u5386\u6295\u9012\u90ae\u7bb1\uff1ainfo@genonet.cn<\/div>\n<div><\/div>\n<div><\/div>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCcBof1z1ClbNQiaYoYF4N7gVsxWuyhTN2ToHsTIIibjqZSY8qQTRqOvgWF821ubnyL2psrKQQH2zXQ.jpeg\" alt=\"RmFicvQBAkgCcBof1z1ClbNQiaYoYF4N7gVsxWuyhTN2ToHsTIIibjqZSY8qQTRqOvgWF821ubnyL2psrKQQH2zXQ\"\/><\/figure><\/div>","protected":false},"excerpt":{"rendered":"<p>\u5b9a\u5236\u5316panel\u4e13\u4e1a\u5206\u6790\u5de1\u8bb2\u4e3a\u4e34\u5e8a\u533b\u751f\u89e3\u51b3\u56f0\u60d1<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[1905],"class_list":["post-9301","post","type-post","status-publish","format-standard","hentry","category-industryresearch","tag-panel"],"_links":{"self":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/9301","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/comments?post=9301"}],"version-history":[{"count":3,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/9301\/revisions"}],"predecessor-version":[{"id":14051,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/9301\/revisions\/14051"}],"wp:attachment":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/media?parent=9301"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/categories?post=9301"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/tags?post=9301"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}