\n![\"RmFicvQBAkgCuC54K47siaoibvbClYbpoQdmoEA7Yo9T0l4l5c9wsK8DWv13zXvBYojNDUX4HpbxOEe8enSicCuVVg\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCuC54K47siaoibvbClYbpoQdmoEA7Yo9T0l4l5c9wsK8DWv13zXvBYojNDUX4HpbxOEe8enSicCuVVg.gif\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n<\/div>\n
\u5173\u952e\u8bcd\/\u80bf\u7624 AACR \u4f1a\u8bae\u7b14\u8bb0 \u6587\/\u57fa\u56e0\u6167\u00a0 \u00a0<\/div>\n
<\/div>\n
\u5317\u4eac\u65f6\u95f42019\u5e744\u67081\u65e5\uff0c\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u5b66\u4f1a2019\u5e74\u4f1a\uff08\u7b80\u79f0 \u201cAACR 2019\u201d\uff09\u5728\u4e9a\u7279\u5170\u5927\u5f00\u5e55\uff0c\u4e3b\u9898\u4e3a\u201c\u901a\u8fc7\u7cbe\u51c6\u7684\u764c\u75c7\u79d1\u5b66\u5171\u8bc6\u5b9e\u73b0\u75c5\u4eba\u516c\u5e73\u62a4\u7406\u201d\u3002\u8d85\u8fc721000\u4eba\u53c2\u4f1a\uff0c\u5f00\u5e55\u5f0f\u62a5\u544a\u91cd\u70b9\u9610\u8ff0\u4e86\u7cbe\u51c6\u533b\u5b66\u3001\u514d\u75ab\u6cbb\u7597\u548c\u53ef\u7a7f\u6234\u8bbe\u5907\u4e09\u5927\u9886\u57df\u7684\u8fdb\u5c55\u3002\u57fa\u56e0\u6167\u5206\u4eab\u5f00\u5e55\u5f0f\u62a5\u544a\u53ca\u4f1a\u8bae\u516c\u5e03\u7684\u6700\u65b0\u764c\u75c7\u7597\u6cd5\u8981\u70b9\u5982\u4e0b\u3002<\/div>\n
\u6ce8\uff1a\u6b22\u8fceAACR\u53c2\u4f1a\u8005\u5206\u4eab\u4f1a\u8bae\u89c1\u95fb\uff08info@genonet.cn\uff09\uff0c\u57fa\u56e0\u6167\u514d\u8d39\u53d1\u5e03<\/div>\n
<\/div>\n
<\/div>\n
\n\n
\n![\"RmFicvQBAkgCgia7Hj0fX2w8ky2ULQegTyYV1StmolruZbC3NvYcjsm8z4Lib74EgWKIPPSWSaULCsju4Eic5bO8uA\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCgia7Hj0fX2w8ky2ULQegTyYV1StmolruZbC3NvYcjsm8z4Lib74EgWKIPPSWSaULCsju4Eic5bO8uA.jpeg\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n<\/div>\n
<\/div>\n
\u00a0\u8981\u70b9\u9884\u89c8\u00a0<\/div>\n
<\/div>\n
\u7269\u7406\u5b66\u5bb6\u548c\u533b\u751f\u8054\u5408\u7814\u53d1\u7684\u80bf\u7624\u60a3\u8005\u53ef\u7a7f\u6234\u8bbe\u5907<\/div>\n
PARP\u6291\u5236\u5242\u548cPARP\u4ecb\u5bfc\u7684\u78b1\u57fa\u5207\u9664\u4fee\u590dDNA<\/div>\n
MSK-IMPACT\u8ba1\u5212\u7684\u5c40\u9650\u548ccfDNA\u8ba1\u5212<\/div>\n
\u764c\u75c7\u57fa\u56e0\u7a81\u53d8\u7684\u201c\u957f\u5c3e\u201d\u5206\u5e03\u548c\u975e\u81f4\u75c5\u57fa\u56e0\u4f9d\u8d56<\/div>\n
CD19 \/ 22\u53cc\u7279\u5f02\u6027CAR-T\u7ec6\u80de\u6cbb\u7597<\/div>\n
\u96be\u6cbb\u80bf\u7624\u7684\u6cbb\u7597\u7a81\u7834\u768412\u5927\u65b9\u6848<\/div>\n
<\/div>\n
<\/div>\n
<\/div>\n
1\u7269\u7406\u5b66\u5bb6\u548c\u533b\u751f\u7684\u8054\u5408\u7814\u53d1\u53ef\u7a7f\u6234\u8bbe\u5907<\/div>\n
<\/div>\n
\n\n
\n![\"RmFicvQBAkgCgia7Hj0fX2w8ky2ULQegTy2eibjsFgljrVP7hSO47ZSsv6M4u35wHWApXhbz4VcjV4M2g4INA3f9g\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCgia7Hj0fX2w8ky2ULQegTy2eibjsFgljrVP7hSO47ZSsv6M4u35wHWApXhbz4VcjV4M2g4INA3f9g.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u5de6\u56fe\uff0cPeter Kuhn\u535a\u58eb\uff1b\u53f3\u56fe\uff0cJohn D. Carpten\u535a\u58eb\u3002\u6765\u81eaAACR\u5b98\u7f51<\/div>\n
Peter Kuhn\u535a\u58eb\uff0c\u8eab\u517c\u751f\u7269\u79d1\u5b66\uff0c\u751f\u7269\u533b\u5b66\u5de5\u7a0b\uff0c\u822a\u7a7a\u822a\u5929\u548c\u673a\u68b0\u5de5\u7a0b\u56db\u4e2a\u9886\u57df\u7684\u6559\u6388; John D. Carpten\u535a\u58eb\uff0c\u5357\u52a0\u5dde\u5927\u5b66\u8bfa\u91cc\u65af\u7efc\u5408\u764c\u75c7\u4e2d\u5fc3\u7684\u4e34\u5e8a\u8840\u6db2\u80bf\u7624\u526f\u6559\u6388\u3002\u4e8c\u4eba\u63d0\u5230\uff0c\u533b\u751f\u548c\u60a3\u8005\u5bf9\u9884\u540e\u72b6\u6001\u7684\u5f80\u5f80\u5b58\u5728\u5206\u6b67\uff0c\u4ece\u800c\u8fdb\u4e00\u6b65\u5f71\u54cd\u764c\u75c7\u6cbb\u7597\u65b9\u6848\u548c\u6548\u679c\u3002\u4ed6\u4eec\u5f00\u53d1\u4e86\u4e00\u4e2a\u540d\u4e3aATOM-HP[3]\u7684\u9879\u76ee\uff0c\u4ece\u53ef\u7a7f\u6234\u8bbe\u5907\u4e2d\u6355\u83b7\u764c\u75c7\u60a3\u8005\u7684\u5065\u5eb7\u548c\u4f53\u80fd\u72b6\u6001\uff0c\u4ee5\u91cf\u5316\u4ed6\u4eec\u7684ECOG\u8bc4\u5206\u8868\u73b0\uff0c\u4f5c\u4e3a\u751f\u7269\u6807\u5fd7\u7269\u6765\u5224\u65ad\u60a3\u8005\u7684\u9884\u540e\u53cd\u5e94\u3002<\/div>\n\n
\n![\"RmFicvQBAkgCgia7Hj0fX2w8ky2ULQegTyRsmzp12qhemqXicusojrOTOFCEEaqIEdRThXjl4pNrfOR7zzoR6f1Iw\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCgia7Hj0fX2w8ky2ULQegTyRsmzp12qhemqXicusojrOTOFCEEaqIEdRThXjl4pNrfOR7zzoR6f1Iw.png\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u56fe\uff0cATOM-HP\u5957\u4ef6\uff0c\u6765\u81eaUSC\u5b98\u7f51<\/div>\n
\u9664\u4e86\u53ef\u7a7f\u6234\u8bbe\u5907\uff0cPeter Kuh\u548cJohn D. Carpten\u8fd8\u8c08\u5230\u6b63\u5f00\u53d1\u4e00\u79cd\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5ba2\u89c2\u5730\u91cf\u5316\u4e86\u60a3\u8005\u4f53\u80fd\u72b6\u6001\u5e76\u6765\u9884\u6d4b\u5065\u5eb7\u72b6\u51b5\u3002\u7279\u522b\u5730\uff0c\u8fd9\u91cc\u5305\u62ec\u56e0\u4e3a\u4f53\u80fd\u4e0d\u4f73\u6ca1\u6cd5\u7eb3\u5165\u5e38\u89c4\u4e34\u5e8a\u8bd5\u9a8c\u7684\u60a3\u8005\u3002<\/div>\n
2DNA\u4fee\u590d\u7f3a\u9677\u6280\u672f\u6cbb\u7597\u764c\u75c7<\/div>\n
\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821Helen Diller\u5bb6\u5ead\u7efc\u5408\u764c\u75c7\u4e2d\u5fc3Alan Ashworth\u535a\u58eb\u8c08\u5230\u4e86DNA\u4fee\u590d\u7f3a\u9677\u5728\u764c\u75c7\u4e2d\u7684\u6cbb\u7597\u610f\u4e49\u3002<\/div>\n\n
\n![\"RmFicvQBAkgCgia7Hj0fX2w8ky2ULQegTyKUxfpKUwFhTenoKlxw0SHeW253JbOYgh3oSj9fTBD674tR3CQRyErA\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCgia7Hj0fX2w8ky2ULQegTyKUxfpKUwFhTenoKlxw0SHeW253JbOYgh3oSj9fTBD674tR3CQRyErA.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u56fe\uff0cAlanAshworth\u535a\u58eb\uff0c\u6765\u81eaAACR\u5b98\u7f51<\/div>\n
Ashworth\u8c08\u5230\uff0cDNA\u4fee\u590d\u8fc7\u7a0b\u4e2d\u7684\u7f3a\u9677\u901a\u5e38\u4f1a\u5bfc\u81f4\u57fa\u56e0\u7a81\u53d8\uff0c\u8fdb\u800c\u52a0\u901f\u764c\u75c7\u53d1\u751f\u3002\u7ec6\u80de\u901a\u8fc7\u591a\u79cdDNA\u635f\u4f24\u53cd\u5e94\u901a\u8def\u6765\u4fee\u590dDNA\u635f\u4f24\u3002\u4f8b\u5982\u5176\u4e2d\u4e00\u6761\u901a\u8def\u6d89\u53caADP\u6838\u7cd6\u805a\u5408\u91761\u548c2\uff08PARP1\u548cPARP2\uff09\uff0c PARP\u6291\u5236\u5242\u901a\u8fc7\u5408\u6210\u81f4\u6b7b(synthetic lethality)\u7684\u539f\u7406\u5bf9\u6297\u764c\u7ec6\u80de\u3002\u5bf9\u4e8eBRCA\u57fa\u56e0\u7f3a\u9677\u5219\u901a\u8fc7PARP\u4ecb\u5bfc\u7684\u78b1\u57fa\u5207\u9664\u673a\u5236\u6765\u4fee\u590d\u3002FDA\u6279\u51c6\u4e86\u4e09\u79cdPARP\u6291\u5236\u5242\uff0colaparib\uff0crucaparib\u548cniraparib\u6765\u6cbb\u7597\u9057\u4f20\u6027BRCA\u7a81\u53d8\u7684\u5375\u5de2\u764c\u60a3\u8005\u3002 olaparib\u548ctalazoparib\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u67d0\u4e9b\u60a3\u6709\u8f6c\u79fb\u6027HER2\u9634\u6027\u4e73\u817a\u764c\u7684\u9057\u4f20\u6027BRCA1 \/ 2\u7a81\u53d8\u60a3\u8005\u3002\u00a0<\/div>\n
\u00a0<\/div>\n
\u4f5c\u4e3a\u6700\u65b0\u53d1\u73b0\uff0cAshworth\u8c08\u5230\uff0c\u5728\u4e00\u9879III\u671f\u5b89\u6170\u5242\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0colaparib\u4f5c\u4e3aBRCA\u80da\u7cfb\u7a81\u53d8\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u7ef4\u6301\u5355\u836f\u6cbb\u7597\u65b9\u6848\uff0c\u5728\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u65b9\u9762\u53d6\u5f97\u4e86\u7edf\u8ba1\u5b66\u4e0a\u7684\u663e\u7740\u6539\u5584\u3002Ashworth\u8fd8\u63d0\u5230\u4e86\u8d85\u8fc710\uff05\u7684\u5df2\u77e5\u764c\u75c7\u60a3\u8005\u5305\u62ecBRCA\u7a81\u53d8\uff08BRCAness\uff09\u3002\u4ed6\u5c06BRCAness\u770b\u4f5c\u4e3a\u4e00\u79cd\u8868\u578b\u6548\u5e94\uff0c\u901a\u8fc7\u8fd9\u79cd\u65b9\u5f0f\u5176\u4ed6\u5206\u5b50\u7f3a\u9677\u8d4b\u4e88BRCA1\u6216BRCA2\u80da\u7cfb\u7a81\u53d8\u76f8\u4f3c\u7684\u8868\u578b\u3002<\/div>\n
\u00a0<\/div>\n
3\u5b9a\u4e49\u548c\u5229\u7528\u53ef\u9776\u5411\u8bca\u7597\u7684\u764c\u75c7\u57fa\u56e0\u7ec4<\/div>\n
Memorial Sloan Kettering\u764c\u75c7\u4e2d\u5fc3\u7684David B. Solit\u535a\u58eb\uff0c\u8c08\u5230\u80bf\u7624\u57fa\u56e0\u7ec4\u5206\u6790\u5728\u786e\u5b9a\u764c\u75c7\u60a3\u8005\u9002\u5f53\u6cbb\u7597\u65b9\u9762\u7684\u6548\u7528\u548c\u6311\u6218\u3002<\/div>\n
\u7279\u522b\u5730\uff0c\u5bf9\u4e8e\u5907\u53d7\u77a9\u76ee\u7684\u83b7FDA\u6279\u51c6\u7684MSK-IMPACT<\/a>\uff0c\u8986\u76d6\u7f55\u89c1\u548c\u5e38\u89c1\u764c\u75c7\u7684\u57fa\u56e0\u7a81\u53d8\u548c\u5176\u4ed6\u5173\u952e\u6027\u9057\u4f20\u7578\u53d8\u7684468\u4e2a\u57fa\u56e0\uff0c\u68c0\u6d4b\u5230\u7684\u57fa\u56e0\u6539\u53d8\u5305\u62ec\u86cb\u767d\u8d28\u7f16\u7801\u7a81\u53d8\uff0c\u62f7\u8d1d\u6570\u6539\u53d8\uff08CNA\uff09\u4ee5\u53ca\u8d85\u8fc7400\u79cd\u764c\u75c7\u76f8\u5173\u57fa\u56e0\u4e2d\u9009\u62e9\u7684\u542f\u52a8\u5b50\u7a81\u53d8\u548c\u7ed3\u6784\u91cd\u6392\u3002\u800cMSK-IMPACT\u7684\u5927\u89c4\u6a21\u524d\u77bb\u6027\u4e34\u5e8a\u6d4b\u5e8f\u8ba1\u5212\uff0c\u4e3b\u8981\u76ee\u7684\u662f\u53d1\u6398\u80bf\u7624\u7684\u5206\u5b50\u9a71\u52a8\u56e0\u7d20\uff0c\u7279\u522b\u662f\u5bfc\u81f4\u764c\u75c7\u53d1\u751f\u7684\u80da\u7cfb\u7a81\u53d8\uff0c\u4ece\u800c\u6765\u8bbe\u8ba1\u5408\u7406\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/div>\n
\u00a0<\/div>\n
Solit\u8fd8\u8c08\u5230MSK-IMPACT\u8ba1\u5212\u7684\u4e00\u4e9b\u5c40\u9650\u6027\uff1a\u5176\u4e00\u4ec5\u5f97\u5230\u7ea625\uff05\u7684 \u60a3\u8005\u80bf\u7624\u56fe\u8c31\uff1b\u5176\u4e8c\uff0c\u4ec5\u68c0\u6d4bpanel\u4e2d\u5df2\u77e5\u7684\u57fa\u56e0\u6539\u53d8\u3002\u4e3a\u4e86\u514b\u670d\u8fd9\u4e9b\u6311\u6218\uff0c2018\u5e74\u8be5\u8ba1\u5212\u7684\u4e3b\u8981\u91cd\u70b9\u662f\u5f00\u53d1\u548c\u9a8c\u8bc1cfDNA\u65b9\u6cd5\u2014\u2014\u5206\u6790\u6765\u81ea129\u4e2a\u57fa\u56e0\u7684\u5916\u663e\u5b50\u7684\u7a81\u53d8\u68c0\u6d4b\u2014\u2014\u7279\u522b\u662f\u5bf9\u4e8e\u6ca1\u6cd5\u83b7\u53d6\u80bf\u7624\u7ec4\u7ec7\u7684\u60a3\u8005\uff0c\u6765\u8bc4\u4f30\u5fae\u5c0f\u6b8b\u7559\u7684\u80bf\u7624\u548c\u65e9\u671f\u5e72\u9884\u7684\u673a\u4f1a\u3002Solit\u6307\u51fa\uff0c\u4e34\u5e8a\u533b\u751f\u9700\u8981\u5b66\u4f1a\u8bc6\u522b\u53ef\u80fd\u80fd\u9776\u5411\u6539\u53d8\u4f46\u7531\u4e8e\u68c0\u6d4b\u6280\u672f\u5c40\u9650\u800c\u9057\u6f0f\u7684\u80bf\u7624\u60a3\u8005\uff0c\u4f8b\u5982DNA\u8d28\u91cf\u5dee\u3001\u95f4\u8d28\u6027\u6d78\u6da6\u6216\u8005\u67d0\u4e9b\u7a81\u53d8\u7684\u8986\u76d6\u5ea6\u4e0d\u591f\u7b49\u3002<\/div>\n
\u00a0<\/div>\n
4\u764c\u75c7\u57fa\u56e0\u7a81\u53d8\u7684\u201c\u957f\u5c3e\u6548\u5e94\u201d\u548c\u7cbe\u51c6\u80bf\u7624\u7684\u5c40\u9650<\/div>\n
\u793c\u6765\u516c\u53f8\u7684\u533b\u5b66\u535a\u58ebLevi A. Garraway\u8c08\u5230\u5f53\u524d\u764c\u75c7\u6cbb\u7597\u7684\u8fdb\u6b65\u53d6\u51b3\u4e24\u4e2a\u91cd\u8981\u56e0\u7d20\uff1a\u4e00\u662f\u80bf\u7624\u751f\u7269\u5b66\u7684\u79d1\u5b66\u53d1\u73b0\uff1b\u4e8c\u662f\u57fa\u56e0\u7ec4\uff08\u6d4b\u5e8f\uff09\u6280\u672f\u540c\u65f6\u5bf9\u6570\u767e\u4e2a\u57fa\u56e0\u8fdb\u884c\u4e34\u5e8a\u5206\u6790\u7684\u6280\u672f\u8fdb\u6b65\u3002<\/div>\n
Garraway\u6307\u51fa\u7cbe\u51c6\u80bf\u7624\u7814\u7a76\u7684\u4e24\u5927\u5c40\u9650\uff1a<\/div>\n
1\uff09\u5927\u89c4\u6a21\u7684\u764c\u75c7\u57fa\u56e0\u7ec4\u7814\u7a76\u8868\u660e\uff0c\u8bb8\u591a\u53ef\u9776\u5411\u8bca\u7597\u7684\uff08actionable\uff09\u764c\u75c7\u57fa\u56e0\u7a81\u53d8\u8868\u73b0\u51fa\u201c\u957f\u5c3e\u201d\u5206\u5e03\uff0c\u8fd9\u610f\u5473\u7740\u5b83\u4eec\u5728\u764c\u75c7\u4e2d\u751a\u81f3\u5728\u7279\u5b9a\u7684\u764c\u75c7\u7c7b\u578b\u4e2d\u662f\u7f55\u89c1\u7684\u3002\u867d\u7136\u8fd9\u4f7f\u5f97\u5b83\u4eec\u96be\u4ee5\u68c0\u6d4b\uff0c\u4f46\u4ece\u6cbb\u7597\u7684\u89d2\u5ea6\u6765\u770b\uff0c\u8bc6\u522b\u8fd9\u79cd\u6539\u53d8\u662f\u975e\u5e38\u6709\u76ca\u7684\uff0c\u4f8b\u5982RET\u6291\u5236\u5242\u3002\u00a0<\/div>\n
2\uff09\u8bb8\u591a\u764c\u75c7\u7684\u975e\u81f4\u764c\u57fa\u56e0\u4f9d\u8d56\uff08\u5176\u4e2d\u5173\u952e\u7684\u764c\u75c7\u86cb\u767d\u8d28\u672c\u8eab\u6ca1\u6709\u53d1\u751f\u7a81\u53d8\uff09\uff0c\u4ee5\u53ca\u5bf9\u80bf\u7624\u5b66\u7684\u6709\u9650\u4e86\u89e3\u60c5\u51b5\u4e0b\u5927\u529b\u63a8\u8fdb\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u662f\u76ee\u524d\u7684\u4e24\u5927\u6311\u6218\u3002\u672a\u6765\u9700\u8981\u6025\u9700\u5173\u6ce8\u80bf\u7624\u5f02\u8d28\u6027\u3001\u6cbb\u7597\u62b5\u6297\uff08therapeutic resistance\uff09\u548c\u57fa\u4e8e\u7cbe\u786e\u80bf\u7624\u5b66\u539f\u7406\u6982\u5ff5\u5f00\u53d1\u5408\u7406\u8054\u5408\u6cbb\u7597\u65b9\u6cd5\u3002<\/div>\n
\u00a0<\/div>\n
5\u65b0\u4e00\u4ee3CAR-T\u7ec6\u80de\u7597\u6cd5<\/div>\n
\u65af\u5766\u798f\u5927\u5b66\u533b\u5b66\u9662\u7684\u533b\u5b66\u535a\u58ebCrystal L. Mackall\uff0c\u8c08\u5230\u4e86\u5bf9CAR-T\u7ec6\u80de\u6cbb\u7597\u7684\u62b5\u6297\u673a\u5236\u53ca\u5176\u514b\u670d\u65b9\u6cd5\u3002<\/div>\n
\u5230\u76ee\u524d\u4e3a\u6b62\uff0cFDA\u6279\u51c6\u4e86\u4e24\u79cdCAR-T\u7ec6\u80de\u7597\u6cd5\u3002 Tisagenlecleucel\uff08Kymriah\uff09\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u67d0\u4e9b\u60a3\u6709\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08ALL\uff09\u548c\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08NHL\uff09\u7684\u513f\u79d1\u548c\u5e74\u8f7b\u6210\u5e74\u4eba\u60a3\u8005\u3002axicabtagene ciloleucel\uff08Yescarta\uff09\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u60a3\u6709\u67d0\u4e9b\u7c7b\u578bNHL\u7684\u6210\u5e74\u4eba\u3002<\/div>\n
CAR-T\u7ec6\u80de\u7597\u6cd5\u6cbb\u7597\u67d0\u4e9b\u8840\u764c\u5df2\u7ecf\u53d6\u5f97\u4e86\u5f88\u9ad8\u7684\u6210\u529f\u7387\uff0c\u4f46\u4e00\u4e9b\u60a3\u8005\u5df2\u7ecf\u5f00\u59cb\u5bf9\u8fd9\u79cd\u6cbb\u7597\u4ea7\u751f\u6297\u6027\u3002Mackall\u6ce8\u610f\u5230\u9488\u5bf9\u8840\u7ec6\u80de\u4e0a\u5b58\u5728\u7684CD19\u7684CAR-T\u7ec6\u80de\u7597\u6cd5\u7684\u6297\u6027\u673a\u5236\uff0c\u5305\u62ec\u80bf\u7624\u9003\u907f\u3001T\u7ec6\u80de\u5931\u6548\uff08T-cell failure\uff09\u548cT\u7ec6\u80de\u8870\u7aed\uff08T-cell exhaustion\uff09\u3002<\/div>\n
\u00a0<\/div>\n
\u80bf\u7624\u6297\u539f\u901a\u8fc7\u591a\u79cd\u673a\u5236\u9003\u9038CAR-T\u7ec6\u80de\u6cbb\u7597\uff1a1\uff09\u901a\u8fc7\u8868\u8fbe\u9776\u5411\u6297\u539f\u7684\u66ff\u4ee3\u5f62\u5f0f\uff0c\u4ece\u800c\u8ba9CAR-T\u7ec6\u80de\u96be\u4ee5\u8bc6\u522b\uff1b2\uff09\u6539\u53d8\u6210\u8868\u578b\u4e0d\u540c\u7684\u75be\u75c5\uff1b3\uff09\u901a\u8fc7\u964d\u4f4e\u8868\u9762\u9776\u6297\u539f\u7684\u8868\u8fbe\u6765\u4f4e\u4e8eCAR-T\u7ec6\u80de\u6d3b\u5316\u6240\u9700\u9608\u503c\u7684\u6c34\u5e73\u3002<\/div>\n
Mackall\u8c08\u5230\uff0c\u6297\u539f\u9634\u6027\u548c\u6297\u539f\u4f4e\u5f15\u8d77\u7684\u80bf\u7624\u590d\u53d1\u662f\u4e00\u4e2a\u4e3b\u8981\u95ee\u9898\uff0c\u7279\u522b\u662f\u5728\u6cbb\u7597\u4e25\u91cd\u4f9d\u8d56\u9776\u6297\u539f\u5f02\u8d28\u6027\u7684\u75be\u75c5\u65f6\u3002 Mackall\u8865\u5145\u8bf4\uff0c\u5728CAR-T\u7ec6\u80de\u8870\u7aed\u6a21\u578b\u4e2d\u7684\u5168\u57fa\u56e0\u7ec4\u5206\u6790\u663e\u793abZIP \/ IRF\u8f6c\u5f55\u56e0\u5b50motif\u5728\u8017\u7aed\u7684\u4ebaT\u7ec6\u80de\u4e2d\u5931\u8c03\u6700\u591a\u3002\u5979\u63a8\u6d4b\uff0c\u5de5\u7a0b\u5316CAR-T\u7ec6\u80de\u6062\u590dbZIP \/ IRF\u7684\u5e73\u8861\u5c06\u63d0\u9ad8CAR-T\u7ec6\u80de\u7684\u529f\u6548\u3002<\/div>\n
\u00a0\u00a0<\/div>\n
Mackall\u63d0\u5230\uff0c\u4e0eCD19\u4e00\u6837\uff0cCD22\u4e5f\u5728\u5927\u591a\u6570B\u7ec6\u80de\u767d\u8840\u75c5\u7ec6\u80de\u4e0a\u8868\u8fbe\uff0c\u4f46\u901a\u5e38\u5728CD19\u4e27\u5931\u540e\u4fdd\u7559\u3002\u5148\u524d\u7684\u7814\u7a76\u8868\u660e\uff0cCD22-CAR-T\u7ec6\u80de\u7684\u5b89\u5168\u6027\u4e0eCD19-CAR-T\u7ec6\u80de\u76f8\u4f3c\uff0c\u4e14\u5728\u514d\u75ab\u6cbb\u7597\u521d\u671f\u60a3\u8005\u548cCD19\u590d\u53d1\u540e\u60a3\u8005\u4e2d\u5747\u4ea7\u751f\u7c7b\u4f3c\u7684\u5f3a\u6548\u6297\u764c\u4f5c\u7528\u3002\u5728\u65af\u5766\u798f\u5927\u5b66\u8fdb\u884c\u513f\u7ae5\u548c\u6210\u4eba\u60a3\u8005\u60a3\u8005\u4e24\u9879CD19 \/ 22\u53cc\u7279\u5f02\u6027CAR-T\u7ec6\u80de\u6cbb\u7597\u6d4b\u8bd5\u7ed3\u679c\u663e\u793a\uff0c\u4e8c\u4ef7CD19 \/ CD22 CAR-T\u7ec6\u80de\u7597\u6cd5\u662f\u5b89\u5168\u7684\u5e76\u4e14\u5177\u6709\u663e\u8457\u7684\u4e34\u5e8a\u6d3b\u6027\u3002Mackall\u8fd8\u8ba8\u8bba\u4e86\u5f00\u53d1\u4e09\u7279\u5f02\u6027\u548c\u56db\u7279\u5f02\u6027CAR-T\u7ec6\u80de\u7597\u6cd5\uff0c\u5e76\u6307\u51fa\u8fd9\u79cd\u9ad8\u7ea7\u7597\u6cd5\u5bf9\u4e8e\u6269\u5c55CAR-T\u7ec6\u80de\u5728\u5b9e\u4f53\u80bf\u7624\u4e2d\u7684\u5e94\u7528\u81f3\u5173\u91cd\u8981\u3002<\/div>\n
\u00a0<\/div>\n
\u6765\u81ea\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u7684E. John Wherry\u535a\u58eb\u8c08\u5230\u8870\u7aedT\u7ec6\u80de\uff08Exhausted T cells\uff09\u2014\u2014\u7b80\u79f0Tex\u7ec6\u80de\u2014\u2014\u5728\u764c\u75c7\u4e2d\u53d1\u6325\u7684\u6838\u5fc3\u4f5c\u7528\u3002Tex\u7ec6\u80de\u7531\u4e8e\u6548\u5e94\u529f\u80fd\u7684\u8fdb\u884c\u6027\u4e27\u5931\uff0c\u591a\u79cd\u6291\u5236\u6027\u53d7\u4f53\u7684\u8868\u8fbe\u589e\u52a0\u548c\u4ee3\u8c22\u6539\u53d8\u5f62\u6210\uff0c\u4e0e\u6548\u5e94\u5b50\u548c\u8bb0\u5fc6T\u7ec6\u80de\u6709\u7740\u4e0d\u540c\u7684\u8868\u89c2\u9057\u4f20\u4fe1\u606f\u3002<\/div>\n
Wherry\u9996\u5148\u5f3a\u8c03\u4e86\u5173\u4e8e\u6297PD-1\u514d\u75ab\u6cbb\u7597\u7684\u91cd\u8981\u95ee\u9898\uff1a\u4e3b\u8981\u7684\u5e94\u7b54\u7ec6\u80de\u7c7b\u578b\u662f\u4ec0\u4e48\uff1f\u5bf9\u68c0\u67e5\u70b9\u6291\u5236\u7684\u54cd\u5e94\u52a8\u529b\u5b66\u662f\u4ec0\u4e48\uff1f\u514d\u75ab\u53cd\u5e94\u7684\u6301\u4e45\u6027\u5982\u4f55\uff1f\u6cbb\u7597\u5931\u8d25\u7684\u673a\u5236\u662f\u4ec0\u4e48\uff1f\u8fd9\u5176\u4e2d\uff0c\u7406\u89e3\u68c0\u67e5\u70b9\u6291\u5236\u663e\u5f97\u975e\u5e38\u91cd\u8981\u3002\u7814\u7a76\u8868\u660e\uff0cTex\u7ec6\u80de\u662fPD-1\u6216CTLA-4\u963b\u65ad\u7684\u4e3b\u8981\u53cd\u5e94\u8005\u4e4b\u4e00\uff0c\u800cTex\u7ec6\u80de\u5bf9\u6297PD-1\u7684\u53cd\u5e94\u5f71\u54cd\u5230\u4e34\u5e8a\u7ed3\u679c\u3002<\/div>\n
\u00a0<\/div>\n
\u901a\u8fc7PD-1\u548cLag-3\u7684\u7ec4\u5408\u963b\u65ad\u4ee5\u53ca\u901a\u8fc7\u5c06PD-1\u963b\u65ad\u4e0eCAR-T\u7ec6\u80de\u7ec4\u5408\uff0c\u53ef\u4ee5\u5b9e\u73b0Tex\u7ec6\u80de\u7684\u9006\u8f6c\u3002\u5bf9\u68c0\u67e5\u70b9\u963b\u65ad\u7684\u53cd\u5e94\u5206\u4e3a\u4e0d\u540c\u7684\u7c7b\u522b\uff0c\u5305\u62ecT\u7ec6\u80de\u5df2\u7ecf\u4ea7\u751f\u6548\u5e94\u7684\u5feb\u901f\u6d88\u9664\u80bf\u7624\uff1b\u6b21\u4e4b\uff0cT\u7ec6\u80de\u8017\u5c3d\uff1b\u518d\u6b21\u4e4b\uff0c\u6ca1\u6709\u53cd\u5e94\uff0c\u9884\u5148\u5b58\u5728\u7684T\u7ec6\u80de\u53cd\u5e94\u964d\u4f4e\uff1b\u6700\u6b21\u4e4b\uff0c\u80bf\u7624\u9003\u9038\u3002\u4ed6\u603b\u7ed3\u8bf4\uff0c\u4e86\u89e3\u8fd9\u4e9b\u4e0d\u540c\u7684\u7c7b\u522b\u6709\u52a9\u4e8e\u5236\u5b9a\u9002\u5f53\u7684\u6cbb\u7597\u7b56\u7565\u3002<\/div>\n
\u00a0<\/div>\n
6\u96be\u6cbb\u80bf\u7624\u7684\u6cbb\u7597\u7a81\u7834\u768412\u5927\u65b9\u6848<\/div>\n
\u4ee5\u4e0b\u4fe1\u606f\u6574\u7406\u81ea\u5fae\u4fe1\u516c\u4f17\u53f7\u201c\u627e\u836f\u5b9d\u5178\u201d\u548c\u201c\u836f\u660e\u5eb7\u5fb7\u201d\u5173\u4e8eAACR 2019\u516c\u5e03\u7684\u80bf\u7624\u6cbb\u7597\u7a81\u7834\u6027\u65b9\u6cd5\u7684\u62a5\u9053\u7684\u6458\u5f55\uff0c\u4ec5\u4f9b\u53c2\u8003\uff0c\u8be6\u89c1\u53c2\u8003\u8d44\u6599[4][5]\u3002<\/div>\n\n
\n![\"RmFicvQBAkgCgia7Hj0fX2w8ky2ULQegTyibSedibRq9aR7Xo6h4NCfObuR1GdAniaVYRD0Y7JJaRnD31PtY0pXwvaA\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCgia7Hj0fX2w8ky2ULQegTyibSedibRq9aR7Xo6h4NCfObuR1GdAniaVYRD0Y7JJaRnD31PtY0pXwvaA.png\")
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\u53c2\u8003\u8d44\u6599\uff1a<\/div>\n
1.https:\/\/blog.aacr.org\/aacr-annual-meeting-2019-opening-plenary-session-wearable-technologies-precision-medicine-and-immunotherapy\/\u00a0<\/div>\n
2. https:\/\/blog.aacr.org\/experts-forecast-cancer-research-and-treatment-advances-in-2019\/<\/div>\n
3. https:\/\/cssi.cancer.gov\/atom-hp<\/div>\n
4. \u5fae\u4fe1\u516c\u4f17\u53f7\u201c\u627e\u836f\u5b9d\u5178\u201d\uff1a\u300a2019AACR\u4f1a\u8bae\u91cd\u70b9\uff1a\u5341\u5927\u96be\u6cbb\u80bf\u7624\u7684\u91cd\u78c5\u7a81\u7834\u6c47\u603b\u300bhttps:\/\/mp.weixin.qq.com\/s\/obxnD4m3JbxK4sgVpBOv5Q<\/a><\/div>\n
5. \u5fae\u4fe1\u516c\u4f17\u53f7\u201c\u836f\u660e\u5eb7\u5fb7\u201d\uff1a\u300aAACR | \u76d8\u70b9\u514d\u75ab\u7ec4\u5408\u7597\u6cd5\u6700\u65b0\u8fdb\u5c55\uff1a\u9664\u4e86\u201c\u53bb\u6389\u5239\u8f66\u201d\uff0c\u8fd8\u8981\u201c\u8e29\u4e0b\u6cb9\u95e8\u201d\u300bhttps:\/\/mp.weixin.qq.com\/s\/LLbp7fa6kYAVu1na8BwoGg<\/a><\/div>\n
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\u00a0 \u7f16\u8005\/Cindy\u00a0 \u00a0\u6821\u5bf9\/Nicole \u00a0\u00a0\u5ba1\u6838\/Mark<\/div>\n
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\n![\"RmFicvQBAkgDJkslCjQ2eianQraykAic9cibUichkIGia8EuLp3BVEkck3PVXluOAXw8KiciaicupVhsldIek3LTFOgChcg\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDJkslCjQ2eianQraykAic9cibUichkIGia8EuLp3BVEkck3PVXluOAXw8KiciaicupVhsldIek3LTFOgChcg.png\")
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<\/figure><\/div>\n\n<\/div>\n\u65b0\u5a92\u4f53\u7f16\u8f91<\/div>\n
\u884c\u4e1a\u5206\u6790\u5e08<\/div>\n
\u57f9\u8bad\u4e13\u5458<\/div>\n
\u7b80\u5386\u6295\u9012\u90ae\u7bb1\uff1ainfo@genonet.cn<\/div>\n
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\u76f8\u5173\u9605\u8bfb<\/div>\n
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\n![\"RmFicvQBAkgDmAdyl4ic1nfL7vH2czfknWbrvcwS66LZmRL4kXByfjdYyibyicpPrib2DF5uXuhUbGlrODzahfjGQIA\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDmAdyl4ic1nfL7vH2czfknWbrvcwS66LZmRL4kXByfjdYyibyicpPrib2DF5uXuhUbGlrODzahfjGQIA.jpeg\")
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\u6d59\u5927\u548c\u829d\u52a0\u54e5\u5927\u5b66\u8054\u8882\u5448\u73b0\u7cbe\u51c6\u533b\u5b66\u4e0e\u5927\u6570\u636e\u76db\u4f1a<\/a><\/p>\n
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\n![\"RmFicvQBAkgDwDDlibn6LGMERd60A1XgibkVTEVrPEb1EoTK1HnjticKMtrzWS4eyuZgibs4H2ErBL6cp0GRTKvEAkg\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDwDDlibn6LGMERd60A1XgibkVTEVrPEb1EoTK1HnjticKMtrzWS4eyuZgibs4H2ErBL6cp0GRTKvEAkg.jpeg\")
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