{"id":9293,"date":"2019-04-14T23:55:52","date_gmt":"2019-04-14T15:55:52","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&#038;mid=100009975&#038;idx=1&#038;sn=c425026fac032ced95ff4042bc928479&#038;chksm=6b7155405c06dc562f84c00042910f90bee5d1ad1b3fd5da0618c3454d73c8662ed0c2b88b9b#rd"},"modified":"2026-04-08T10:25:47","modified_gmt":"2026-04-08T02:25:47","slug":"979753","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2019\/04\/14\/979753\/","title":{"rendered":"\u6700\u5927\u89c4\u6a21\u57fa\u56e0\u5927\u6570\u636e\u7814\u7a76\uff1a193\u4e07\u5b55\u5987\u65e0\u521b\u4ea7\u524d\u57fa\u56e0\u7b5b\u67e5\u53d1\u73b0\u5b55\u671f\u80bf\u7624"},"content":{"rendered":"<p><!-- wechat_content_hash: aa59ff7a2e6b980c --><\/p>\n<div><\/div>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCuC54K47siaoibvbClYbpoQdmoEA7Yo9T0l4l5c9wsK8DWv13zXvBYojNDUX4HpbxOEe8enSicCuVVg.gif\" alt=\"RmFicvQBAkgCuC54K47siaoibvbClYbpoQdmoEA7Yo9T0l4l5c9wsK8DWv13zXvBYojNDUX4HpbxOEe8enSicCuVVg\"\/><\/figure><\/div>\n\n<div>\u5173\u952e\u8bcd\/NIPT \u5b55\u671f\u80bf\u7624<\/div>\n<div>\u4f5c\u8005\/\u8305\u77db\u00a0 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class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCIniaBVXdZJGhprQkPPCBddPJY9KmARnrXicLD8iaJAJ2rmAlq9VRxXmGvibsSSnxLDiaFZZBnpKLp5Ig.png\" alt=\"RmFicvQBAkgCIniaBVXdZJGhprQkPPCBddPJY9KmARnrXicLD8iaJAJ2rmAlq9VRxXmGvibsSSnxLDiaFZZBnpKLp5Ig\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe1\uff1a\u65e0\u521b\u4ea7\u524d\u57fa\u56e0\u7b5b\u67e5\uff08NIPS\uff09\u793a\u610f\u56fe<\/div>\n<div>\u5373\u901a\u8fc7\u5b55\u5987\u5916\u5468\u8840\u63d0\u524d\u7b5b\u67e5\u80ce\u513fDNA\u7b5b\u67e5\u80ce\u513f\u9057\u4f20\u6027\u75be\u75c5\u3002<\/div>\n<div>\u4e00\u6545\u4e8b\u6846\u67b6\uff08\u6587\u732e\u7b80\u4ecb\uff09<\/div>\n<div>1. \u4e3a\u4ec0\u4e48\u505a\u8fd9\u9879\u7814\u7a76\uff08\u7814\u7a76\u76ee\u7684\uff09<\/div>\n<div>1\uff09\u968f\u7740\u73b0\u4ee3\u4eba\u7684\u89c2\u5ff5\u53ca\u201c\u4e8c\u80ce\u201d\u653f\u7b56\uff0c\u5973\u6027\u7d2f\u8ba1\u7684\u5b55\u671f\u65f6\u95f4\u5ef6\u957f\uff0c\u9ad8\u9f84\u4ea7\u5987\u589e\u591a\uff0c\u63d0\u9ad8\u4e86\u5b55\u5987\u7f79\u60a3\u6076\u6027\u80bf\u7624\u7684\u6982\u7387\u30102\u3011\u3002<\/div>\n<div>2\uff09\u540c\u65f6\uff0c\u5b55\u671f\u89c4\u907fX\u5149\u3001CT\u548cMRI\u7b49\u5e38\u89c4\u68c0\u67e5\uff0c\u4e14\u80bf\u7624\u6807\u5fd7\u7269\u6307\u6807\u4f1a\u53d7\u5230\u5b55\u671f\u7684\u5f71\u54cd\uff0c\u5bfc\u81f4\u5b55\u5987\u80bf\u7624\u65e0\u6cd5\u53ca\u65f6\u6709\u6548\u53d1\u73b0\u3002<\/div>\n<div>3)\u00a0NIPT\u7b5b\u67e5\u4e2d\u51fa\u73b0\u7684\u591a\u4e2a\u67d3\u8272\u4f53\u975e\u6574\u500d\u4f53\u53ef\u80fd\u4e0e\u6bcd\u4f53\u6076\u6027\u80bf\u7624\u6709\u5173\uff0c\u5e76\u53ef\u5bfc\u81f4\u65e0\u521b\u4ea7\u524d\u7b5b\u67e5\uff08NIPS\uff09\u7684\u5931\u8d25\uff0c\u4f46\u5e38\u89c4NIPS\u5bf9\u8bca\u65ad\u6bcd\u4f53\u6076\u6027\u80bf\u7624\u6709\u8f83\u4f4e\u7684\u7279\u5f02\u6027\u548c\u9009\u62e9\u6027\uff08Selectivity)\u3002<\/div>\n<div>\u57fa\u4e8e\u6b64\uff0c\u534e\u5927\u57fa\u56e0\u8054\u5408\u56fd\u5185\u5916\u6570\u5341\u5bb6\u533b\u9662\u53ca\u4e9a\u6d32\u3001\u6b27\u6d32\u76f8\u5173\u673a\u6784\u5386\u65f6\u4e09\u5e74\uff0c\u8fdb\u884c\u6b64\u8fd1\u4e24\u767e\u4e07\u4f8b\u7684\u5927\u89c4\u6a21\u7684\u7814\u7a76\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCIniaBVXdZJGhprQkPPCBddx9ic9yfPc3ssMnLia97UgJQjsRxVyJ4RpFTx0pgoCtfEdejVvjiatYeag.png\" alt=\"RmFicvQBAkgCIniaBVXdZJGhprQkPPCBddx9ic9yfPc3ssMnLia97UgJQjsRxVyJ4RpFTx0pgoCtfEdejVvjiatYeag\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe2\uff1a\u00a0a.\u00a0\u7814\u7a76\u53d1\u73b0\u7684\u80bf\u7624\u7c7b\u578b\u53ca\u6570\u76ee\u00a0b.\u00a0\u53d1\u73b0\u7684\u764c\u75c7\u9636\u6bb5\uff08NA\u4e3a\u672a\u77e5\uff09\uff0c\u6765\u81ea\u6587\u732e[1]<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCIniaBVXdZJGhprQkPPCBddbbCH6TGrpeiaOu1lqY60WT4TkmgcNLfVhdSkHGD1eofBWejcy5rb2Yw.png\" alt=\"RmFicvQBAkgCIniaBVXdZJGhprQkPPCBddbbCH6TGrpeiaOu1lqY60WT4TkmgcNLfVhdSkHGD1eofBWejcy5rb2Yw\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe3\uff1a\u6548\u679c\u8bc4\u4ef7\u7684Kaplan\u2013Meier\u00a0plots<\/div>\n<div>2.\u00a0\u79d1\u5b66\u5bb6\u53d1\u73b0\u4e86\u4ec0\u4e48\uff1f\uff08\u7814\u7a76\u7ed3\u679c\u548c\u7ed3\u8bba\uff09<\/div>\n<div>\u56de\u987e\u6027\u5730\u7814\u7a76\u8d85\u8fc7193\u4e07\u540d\u63a5\u53d7NIPS\u7684\u5b55\u5987\u8bb0\u5f55\uff0c\u786e\u8bca\u4e86639\u540d\u5b55\u5987\u7684\u80ce\u513f\u51fa\u73b0\u591a\u4e2a\u67d3\u8272\u4f53\u975e\u6574\u500d\u4f53\u9633\u6027\u3002\u5728\u8fd9639\u540d\u53d7\u68c0\u8005\u4e2d\uff0c\u786e\u8bca\u4e8641\u4f8b\u4ea7\u5987\u60a3\u6709\u6076\u6027\u80bf\u7624\u3002\u591a\u4e2a\u67d3\u8272\u4f53\u975e\u6574\u500d\u4f53\u9884\u6d4b\u6bcd\u4f53\u6076\u6027\u80bf\u7624\u7684PPV\u00a0\uff08positive\u00a0predictive\u00a0value\uff0c\u9633\u6027\u9884\u6d4b\u503c\uff09\u4e3a7.6\uff05\u3002\u00a0\u901a\u8fc7\u7814\u53d1\u7684CDP\uff08cancerdetection\u00a0pipeline\uff09\u7b97\u6cd5\u4e0e\u8840\u6d46\u80bf\u7624\u6807\u5fd7\u7269\u68c0\u6d4b\u7ec4\u5408\u5f97\u5230PPV\u4e3a75.0\uff05\u3002<\/div>\n<div>\u6587\u7ae0\u7684\u7ed3\u679c\u5c55\u793a\uff0c\u5728NIPS\u68c0\u6d4b\u4e2dCDP\u7b97\u6cd5\u53ef\u4ee5\u5728\u591a\u4e2a\u67d3\u8272\u4f53\u975e\u6574\u500d\u4f53\u9633\u6027\u5b55\u5987\u4e2d\u8bca\u65ad\u51fa\u5177\u6709\u5408\u7406PPV\u7684\u9690\u533f\u6027\u6bcd\u4f53\u6076\u6027\u80bf\u7624\uff0c\u7ed3\u5408\u8840\u6d46\u80bf\u7624\u6807\u5fd7\u7269\u68c0\u6d4b\u6548\u679c\u66f4\u4f73\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCIniaBVXdZJGhprQkPPCBdde2V5sibEoPuwYrzAezN7lY59uYUQkGazIOkweFnYtibMrBS7Hej09yDw.png\" alt=\"RmFicvQBAkgCIniaBVXdZJGhprQkPPCBdde2V5sibEoPuwYrzAezN7lY59uYUQkGazIOkweFnYtibMrBS7Hej09yDw\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe4\uff1a\u764c\u75c7\u8bca\u65ad\u7b97\u6cd5CDP\u6d41\u7a0b\u56fe\uff0c\u6765\u81ea\u6587\u732e[1]<\/div>\n<div>\u00a0<\/div>\n<div>3. \u8fd9\u9879\u7814\u7a76\u7684\u4e3b\u8981\u65b9\u6cd5\uff08\u65b9\u6cd5\u5b66\uff09<\/div>\n<div>\u3010\u6837\u672c\u30112016\u5e741\u6708\u81f32017\u5e7412\u6708\u671f\u95f4193\u4e07\u540d\u63a5\u53d7NIPS\u7684\u5b55\u5987\u7684\u8bb0\u5f55\uff0c\u5728\u521d\u59cbNIPS\u6d4b\u8bd5\u4e2d\u68c0\u6d4b\u51fa\u591a\u4e2a\u67d3\u8272\u4f53\u975e\u6574\u500d\u4f53\u9633\u6027\u7684639\u540d\u5b55\u5987\u3002\u53d1\u73b0\u768441\u4f8b\u5b55\u671f\u80bf\u7624\u75c5\u4eba\u6765\u81ea\u4e8e\u4e2d\u56fd\u7b49\u4e9a\u6d32\u5730\u533a\u548c\u6b27\u6d32\u5730\u533a\u3002<\/div>\n<div>\u3010\u751f\u7269\u4fe1\u606f\u5b66\u3011\u57fa\u4e8e\u57fa\u56e0\u7ec4\u56fe\u8c31\u6765\u5206\u6790\u57fa\u56e0\u62f7\u8d1d\u6570\u53d8\u5f02\uff08CNV\uff09\uff0c\u5e76\u7814\u53d1\u764c\u75c7\u98ce\u9669\u7b97\u6cd5CDP\uff0c\u6bd4\u8f83\u4e86\u591a\u79cd\u67d3\u8272\u4f53\u975e\u6574\u500d\u4f53\u3001CDP\u6a21\u578b\u4ee5\u53ca\u7ec4\u5408CDP\u548c\u8840\u6d46\u80bf\u7624\u6807\u5fd7\u7269\u7684\u65b9\u6cd5\uff0c\u8ba1\u7b97\u8bca\u65ad\u6bcd\u4f53\u6076\u6027\u80bf\u7624\u7684\u654f\u611f\u6027\u3001\u7279\u5f02\u6027\u548c\u9633\u6027\u9884\u6d4b\u503c\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgA9p4FTloRzLiaY4WDibtOte98jhibKrMZaTzwJKaBQh1ZZ9TFwTWXBHQQ7gKsc530PCkGxdeBeOnW2w.png\" alt=\"RmFicvQBAkgA9p4FTloRzLiaY4WDibtOte98jhibKrMZaTzwJKaBQh1ZZ9TFwTWXBHQQ7gKsc530PCkGxdeBeOnW2w\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u8305\u77db\u00a0PhD\uff0cMD<\/div>\n<div style=\"text-align: center;\">SeekIn\uff08\u601d\u52e4\uff09\u521b\u59cb\u4eba&amp;CEO<\/div>\n<div>\u57fa\u56e0\u548c\u5065\u5eb7\u6570\u636e\u5171\u4eab\u7684\u5021\u5bfc\u8005\u30021996\u5e74\u6bd5\u4e1a\u4e8e\u4e0a\u6d77\u7b2c\u4e8c\u533b\u79d1\u5927\u5b66\uff0c\u5e08\u4ece\u8457\u540d\u7684\u8840\u6db2\u5b66\u548c\u9057\u4f20\u5b66\u4e13\u5bb6\u738b\u632f\u4e49\u9662\u58eb\u548c\u9648\u7afa\u9662\u58eb\u3002\u4e0a\u6d77\u56fd\u5bb6\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u5fc3\u521b\u59cb\u6210\u5458\u300230\u5e74\u4e34\u5e8a\u3001\u9057\u4f20\u5b66\u3001\u57fa\u56e0\u7ec4\u5b66\u53ca\u836f\u7269\u7814\u53d1\u7ecf\u9a8c\u3002\u5728\u9ed8\u6c99\u4e1c\u3001\u8f89\u745e\u5de5\u4f5c\u768415\u5e74\u671f\u95f4\uff0c\u4e3b\u8981\u8d1f\u8d23\u836f\u7269\u57fa\u56e0\u7ec4\u5b66\u548c\u5206\u5b50\u8bca\u65ad\u7684\u7814\u7a76\u3002\u7f8e\u56fdFDA\u6279\u51c6\u7684\u4e73\u817a\u764c\u9884\u540e\u5224\u65ad\u8bd5\u5242\u76d2MammaPrint\u00a0(\u4e16\u754c\u4e0a\u7b2c\u4e00\u4e2a\u591a\u53d8\u91cf\u68c0\u6d4b\u65b9\u6cd5\uff0c2007\u5e74\u83b7\u6279)\u00a0\u7684\u53d1\u660e\u4eba\u4e4b\u4e00\u3002\u4ed6\u8fd8\u505a\u8fc7\u5987\u4ea7\u79d1\u533b\u751f\u548c\u9057\u4f20\u54a8\u8be2\u987e\u95ee\uff0c\u524d\u540e\u5728SCI\u671f\u520a\u4e2d\u53d1\u8868\u4e86100\u4f59\u7bc7\u5b66\u672f\u8bba\u6587\uff0c\u66fe\u83b7\u6559\u80b2\u90e8\u6770\u51fa\u9752\u5e74\u6559\u5e08\u5956\u3001\u4e0a\u6d77\u5e02\u94f6\u86c7\u5956\u3001\u4e0a\u6d77\u5e02\u66d9\u5149\u5b66\u8005\u7b49\u8363\u8a89\u548c\u5956\u9879\u3002<\/div>\n<div>\u6ce8\uff1a\u6b64\u7814\u7a76\u662f\u8305\u77db\u535a\u58eb\u65f6\u4efb\u534e\u5927\u57fa\u56e0\u9996\u5e2d\u79d1\u5b66\u5bb6\u65f6\u53c2\u4e0e\u4e3b\u5bfc\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u4e8c\u901a\u8baf\u4f5c\u8005\u89e3\u8bfb\uff08\u8ba8\u8bba\uff09<\/div>\n<div>\uff08\u7f16\u8005\uff1a\u4ee5\u4e0b\u7ed3\u5408\u4e86\u6587\u732e\u3001\u6280\u672f\u548c\u884c\u4e1a\uff0c\u8305\u77db\u535a\u58eb\u548c\u57fa\u56e0\u6167\u5171\u540c\u7f16\u5199\uff09<\/div>\n<div>1. \u91cd\u5927\u5386\u53f2\u610f\u4e49\u548c\u4eae\u70b9<\/div>\n<div>\u8fd9\u662f\u5386\u53f2\u4e0a\u6700\u5927\u89c4\u6a21\u7684\u57fa\u56e0\u7ec4\u5927\u6570\u636e\u7814\u7a76\u3002\u4e5f\u662f\u65e0\u521b\u4ea7\u524d\u57fa\u56e0\u68c0\u6d4b\u53d1\u73b0\u5b55\u671f\u80bf\u7624\u9886\u57df\u6700\u7cfb\u7edf\u3001\u6700\u7ec6\u5316\u7684\u7814\u7a76\u3002<\/div>\n<div>\u540c\u65f6\uff0c\u4e3a\u4e86\u63d0\u9ad8\u6709\u6548\u6027\uff0c\u6b64\u9879\u76ee\u5f00\u53d1\u4e86\u65e0\u521b\u4ea7\u524d\u57fa\u56e0\u68c0\u6d4b\u6570\u636e\u53d1\u73b0\u5b55\u671f\u80bf\u7624\u7684\u7b97\u6cd5CDP\u5e76\u7ecf\u8fc7\u4e86\u9a8c\u8bc1\uff0c\u964d\u4f4e\u4e86\u5047\u9633\u6027\u3002\u540c\u65f6\u7ed3\u5408\u4e86\u8840\u6d46\u80bf\u7624\u6807\u8bb0\u7269\uff08PTMs\uff09\uff0c\u8fdb\u4e00\u6b65\u63d0\u9ad8\u4e86PPV\u3002<\/div>\n<div>NIPS\u610f\u5916\u53d1\u73b0\u5b55\u671f\u80bf\u7624\u5982\u4f55\u62a5\u544a\uff0c\u6b64\u7814\u7a76\u7528\u6570\u636e\u63d0\u51fa\u4e86\u6307\u5bfc\u610f\u89c1\uff0c\u672a\u6765\u6709\u671b\u8fdb\u4e00\u6b65\u4f5c\u4e3a\u4e34\u5e8a\u6307\u5357\u610f\u89c1\u7684\u53c2\u8003\u4f9d\u636e\u3002<\/div>\n<div>\u9664\u4e86\u4ea7\u79d1\u89d2\u5ea6\uff0c\u6b64\u7814\u7a76\u501f\u9274\u4e86\u4e34\u5e8a\u80bf\u7624\u5b66\u7684\u601d\u8def\uff0c\u6bd4\u5982\u7ecf\u5e38\u7528\u4e8e\u5206\u6790\u764c\u75c7\u751f\u5b58\u7387Kaplan\u2013Meier\u00a0plots\u753b\u56fe\u65b9\u6cd5\u3002<\/div>\n<div>\u00a0<\/div>\n<div>2. \u6b64\u65b9\u6cd5\u4e0d\u80fd\u4f5c\u4e3a\u80bf\u7624\u7b5b\u67e5<\/div>\n<div>\u9700\u8981\u7279\u522b\u5f3a\u8c03\u7684\u662f\uff0c\u8fd9\u9879\u7814\u7a76\u4e3b\u8981\u9488\u5bf9NIPT\/NIPS\u5bf9\u5b55\u671f\u80bf\u7624\u7684\u610f\u5916\u53d1\u73b0\uff0c\u4e0d\u80fd\u4f5c\u4e3a\u5b55\u671f\u80bf\u7624\u65e9\u671f\u7b5b\u67e5\u7684\u65b9\u6cd5\uff0c\u56e0\u4e3a\u7075\u654f\u5ea6\u8f83\u4f4e\u3002<\/div>\n<div>\u00a0<\/div>\n<div>3.\u00a0NIPT\/NIPS\u4e3a\u5987\u5e7c\u5065\u5eb7\u7684\u653f\u7b56\u6307\u5357\u63d0\u4f9b\u6307\u5bfc\u610f\u89c1<\/div>\n<div>\u591a\u4e2a\u67d3\u8272\u4f53\u975e\u6574\u500d\u4f53\u7684\u53d1\u751f\u7387\u4e3a0.03\uff05\uff08\u6211\u56fd2017\u5e74\u65b0\u751f\u513f\u6570\u4e3a1758\u4e07\u4eba\uff09\uff0c\u4e0e\u4e4b\u524d\u76f8\u5173\u7814\u7a76\u4e00\u81f4\uff0c\u4e3aNIPS\u7684\u5927\u6570\u636e\u7814\u7a76\u53ca\u516c\u5171\u536b\u751f\u5b66\u63d0\u4f9b\u4e86\u8fdb\u4e00\u6b65\u7684\u6570\u636e\u652f\u6301\u3002\u7279\u522b\u662fNIPT\/NIPS\u4e2d\u610f\u5916\u53d1\u73b0\u5b55\u671f\u80bf\u7624\uff0c\u4e3a\u540e\u7eed\u4ea7\u79d1\u3001\u80bf\u7624\u79d1\u3001\u57fa\u56e0\u5b66\u76f8\u5173\u7684\u6307\u5357\u89c4\u8303\u63d0\u4f9b\u4e86\u6848\u4f8b\u53c2\u8003\u3002<\/div>\n<div>\u00a0<\/div>\n<div>4. NIPT\/NIPS\u6280\u672f\u4ecd\u9700\u5b8c\u5584\uff0c\u4ea7\u4e1a\u4ecd\u6709\u53d1\u5c55\u7a7a\u95f4<\/div>\n<div>\u76ee\u524d\uff0c\u56fd\u5185\u534e\u5927\u57fa\u56e0\u3001\u8d1d\u745e\u548c\u5eb7\u3001\u8fbe\u5b89\u57fa\u56e0\u3001\u5929\u660a\u8bca\u65ad\uff08\u9488\u5bf9\u81ea\u7136\u6d41\u4ea7\u7ec4\u7ec7\uff09\u3001\u7eb3\u6d77\u9ad8\u79d1\u7b49\u673a\u6784\u62ff\u5230\u4e86\u80ce\u513f\u67d3\u8272\u4f53\u975e\u6574\u500d\u4f53\uff08T21\u3001T18\u3001T13\uff09\u68c0\u6d4b\u8bd5\u5242\u76d2\u7684\u8d44\u8d28\uff0c\u4f18\u8fc5\u533b\u5b66\u7b49\u591a\u5bb6\u4f01\u4e1a\u4e5f\u79ef\u6781\u5e03\u5c40NIPT\u00a0Plus\uff08\u62d3\u5c55\u5fae\u91cd\u590d\u7b49\u66f4\u5927\u8303\u56f4\u7684\u5b55\u5987\u65e0\u521b\u4ea7\u524d\u57fa\u56e0\u7b5b\u67e5\u8303\u56f4\uff09\uff0cNMPA\u4e5f\u4e8e2017\u5e74\u53d1\u5e03\u4e86\u80ce\u513f\u67d3\u8272\u4f53\u975e\u6574\u500d\u4f53\uff08T21\u3001T18\u3001T13\uff09\u68c0\u6d4b\u8bd5\u5242\u76d2\uff08\u9ad8\u901a\u91cf\u6d4b\u5e8f\u6cd5\uff09\u6ce8\u518c\u6280\u672f\u5ba1\u67e5\u6307\u5bfc\u539f\u5219[3]\u3002\u8d44\u672c\u4e5f\u628aNIPT\/NIPS\u4f5c\u4e3a\u6210\u719f\u8d5b\u9053\u3002\u4f46\u6211\u4eec\u53ef\u4ee5\u770b\u5230\uff0c\u5f53\u524d\u4ea7\u54c1\u53ea\u89e3\u51b3\u4e86\u90e8\u5206\u75be\u75c5\u7b5b\u67e5\/\u8bca\u65ad\uff0c\u6280\u672f\u4ecd\u9700\u8fdb\u4e00\u6b65\u7684\u8fed\u4ee3\uff0c\u4ea7\u4e1a\u4e5f\u5c1a\u672a\u5f62\u6210\u7edd\u5bf9\u7684\u5784\u65ad\uff08\u9664\u53bb\u90e8\u5206\u4f01\u4e1a\u7684\u90e8\u5206\u5730\u65b9\u653f\u5e9c\u6e20\u9053\u6a21\u5f0f\uff09\u3002<\/div>\n<div>\u00a0<\/div>\n<div>5.\u00a0\u5b55\u5987\u8fdb\u884cNIPS\u65f6\u662f\u5426\u544a\u77e5\u610f\u5916\u7684\u80bf\u7624\uff1f<\/div>\n<div>\u6839\u636e\u56fd\u5185\u90e8\u5206\u4e34\u5e8a\u533b\u751f\uff0c\u5bf9\u4e8e\u60a3\u8005\u4e3b\u8bc9\u4ee5\u5916\u53d1\u73b0\u7684\u5176\u4ed6\u75be\u75c5\u9633\u6027\uff0c\u4e0d\u4e00\u5b9a\u4f1a\u544a\u77e5\u60a3\u8005\u3002\u4e00\u65b9\u9762\uff0c\u8fd9\u91cc\u8003\u8651\u5b55\u5987\u6000\u5b55\u671f\u95f4\u7406\u89e3\u548c\u4f20\u8fbe\u80bf\u7624\u5e26\u6765\u7684\u5f71\u54cd\uff0c\u518d\u8005\uff0c\u53ef\u80fd\u53ea\u6709\u4e00\u5c0f\u90e8\u5206\u764c\u75c7\u60a3\u8005\u53ef\u4ee5\u4ece\u5176\u764c\u75c7\u98ce\u9669\u4e2d\u83b7\u76ca\uff0c\u53ef\u4ee5\u53ca\u65f6\u8bca\u65ad\u548c\u6cbb\u7597\uff0c\u4f46\u591a\u79cd\u67d3\u8272\u4f53\u975e\u6574\u500d\u4f53\u7ed3\u679c\u7684\u9ad8\u5047\u9633\u6027\u7387\u5c06\u5bfc\u81f4\u7edd\u5927\u591a\u6570\u5b55\u5987\u7684\u4e0d\u5fc5\u8981\u7684\u538b\u529b\u548c\u540e\u7eed\u53ef\u80fd\u4fb5\u5165\u6027\u968f\u8bbf\u68c0\u6d4b\u3002\u53e6\u4e00\u65b9\uff0c\u8fd9\u91cc\u6d89\u53ca\u60a3\u8005\u77e5\u60c5\u6743\u548c\u533b\u60a3\u6c9f\u901a\u4f53\u7cfb\u7684\u590d\u6742\u56e0\u7d20\uff0c\u5305\u62ec\u4e34\u5e8a\u9057\u4f20\u5b66\u3001\u5987\u4ea7\u79d1\u548c\u80bf\u7624\u4e0d\u540c\u9886\u57df\u4e13\u5bb6\u7684\u4e0d\u540c\u89c6\u89d2\u3002<\/div>\n<div>\u63a8\u800c\u5e7f\u4e4b\uff0c\u60a3\u8005\u4e3b\u8bc9\u65e0\u5173\u7684\u75be\u75c5\u662f\u5426\u544a\u77e5\uff08\u5373\u60a3\u8005\u770bA\u75c5\uff0c\u7ed3\u679c\u68c0\u67e5\u65f6\u610f\u5916\u53d1\u73b0B\u75c5\uff09\uff1f<\/div>\n<div>\u00a0<\/div>\n<div>\u57282018\u5e74\u300a\u4e2d\u534e\u9057\u4f20\u5b66\u300b\u6742\u5fd7\u53d1\u8868\u7684\u300a\u4e34\u5e8a\u57fa\u56e0\u68c0\u6d4b\u62a5\u544a\u89c4\u8303\u4e0e\u57fa\u56e0\u68c0\u6d4b\u884c\u4e1a\u5171\u8bc6\u63a2\u8ba8\u300b(\u53ef\u8fdb\u5165\u201c\u9605\u8bfb\u539f\u6587\u201d\u5728YourMap\u4e2d\u70b9\u51fb\u77e5\u8bc6\u5e93\u641c\u7d22\u4e0b\u8f7d\uff09\u63d0\u5230\uff1a\u201c\u82e5\u6709\u53d7\u68c0\u8005\u77e5\u60c5\u540c\u610f\u8981\u6c42\u62a5\u544a\u7684\u610f\u5916\u53d1\u73b0\uff0c\u4e5f\u9700\u5217\u51fa\u81f4\u75c5\u6027\u660e\u786e\u7684\u53d8\u5f02\u5e76\u52a0\u4ee5\u89e3\u8bfb\uff0c\u5176\u4ed6\u4e0e\u4e3b\u8bc9\u65e0\u5173\u8005\u5219\u4e0d\u5fc5\u5728\u62a5\u544a\u4e2d\u8d58\u8ff0\u201d\uff0c\u4e2d\u4fe1\u6e58\u96c5\u7684\u4e13\u5bb6\u4e4b\u540e\u63d0\u51fa\u4e0d\u540c\u770b\u6cd5\uff0c\u8ba4\u4e3a\u201c\u9664\u975e\u662f\u89c4\u5b9a\u8981\u62a5\u544a\u7684\u610f\u5916\u53d1\u73b0\uff0c\u5982\u533b\u751f\u548c\u60a3\u8005\u6709\u7279\u6b8a\u9700\u8981\uff0c\u53ef\u914c\u60c5\u5217\u5165\u9644\u4ef6\u201d\u3002\u8fd9\u91cc\u9664\u4e86\u8003\u8651\u533b\u60a3\u6c9f\u901a\u4f53\u7cfb\u3001\u79d1\u5b66\u6027\u548c\u5e72\u9884\u53ef\u53ca\u6027\uff0c\u7f16\u8005\u5efa\u8bae\u5728\u6b64\u7c7b\u524d\u6cbf\u79d1\u5b66\u65b9\u6cd5\u4e2d\u9700\u7eb3\u5165\u4eba\u9053\u4e3b\u4e49\u7684\u8003\u8651\uff0c\u540c\u65f6\u76f8\u5173\u653f\u7b56\u5bf9\u5e94\u4e3a\u6280\u672f\u672a\u6210\u719f\u5e26\u6765\u7684\u76f8\u5173\u98ce\u9669\u8fdb\u884c\u76d1\u7ba1\u548c\u4f53\u7cfb\u5e73\u8861\uff0c\u5305\u62ec\u53d7\u68c0\u8005\u3001\u7b2c\u4e09\u65b9\u68c0\u6d4b\u673a\u6784\u3001\u4e34\u5e8a\u533b\u751f\u3001\u533b\u9662\u3001\u4fdd\u9669\u673a\u6784\u7b49\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u9644\uff1a\u901a\u8fc7NIPT\u610f\u5916\u53d1\u73b0\u5b55\u671f\u6076\u6027\u80bf\u7624\u7684\u6848\u4f8b\u4fe1\u606f<\/div>\n<div>\uff08\u90e8\u5206\u53c2\u8003\u5fae\u4fe1\u516c\u4f17\u53f7&#8221;\u534e\u5927\u533b\u5b66&#8221;\u7684\u6587\u7ae0\uff09[4]<\/div>\n<div>1\uff092013\u5e74\uff0cOsborne\u00a0CM\u7b49\u5728\u65e0\u521b\u4ea7\u524d\u57fa\u56e0\u68c0\u6d4b\u5931\u8d25\u7684\u5b55\u5987\u4e2d\u786e\u8bca\u4e00\u540d\u5b55\u5987\u786e\u8bca\u5c0f\u7ec6\u80de\u764c\uff08\u9634\u9053\u6765\u6e90\uff09\u3002\u6b64\u60a3\u8005\u7684\u80ce\u513f\u53d1\u73b013\u548c18\u53f7\u67d3\u8272\u4f53\u591a\u500d\u4f53\uff0c\u4f46\u6838\u578b\u6b63\u5e38\u00a0[5]\u3002<\/div>\n<div>2\uff092015\u5e74\uff0cBianchi\u00a0DW\u7b49\u5bf9125426\u4f8b\u5b55\u5987\u8fdb\u884c\u65e0\u521b\u4ea7\u524d\u57fa\u56e0\u68c0\u6d4b\uff0c\u53d1\u73b010\u4f8b\u60a3\u6709\u5b55\u671f\u6076\u6027\u80bf\u7624[6]\u3002<\/div>\n<div>3\uff092016\u5e74\uff0c\u53f0\u6e7e\u8363\u6c11\u603b\u533b\u9662\u3001\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u65b0\u534e\u533b\u9662\u4e0e\u534e\u5927\u57fa\u56e0\u9996\u6b21\u5728\u4e9a\u6d32\u4eba\u7fa4\u63a5\u53d7\u65e0\u521b\u4ea7\u524d\u57fa\u56e0\u68c0\u6d4b\u65f6\uff0c\u53d1\u73b0\u598a\u5a20\u5408\u5e76\u65e0\u6027\u7ec6\u80de\u764c\u548c\u80c3\u764c[8]\u3002<\/div>\n<div>\u00a0 \u7f16\u8f91\/Mark\u00a0 \u00a0\u6821\u5bf9\/Nicole \u00a0\u00a0\u5ba1\u6838\/\u5e03\u4e09\u5c11\u3001\u8305\u77db<\/div>\n<div>\u00a0<\/div>\n<div>\u52a0\u5165\u57fa\u56e0\u6167\u8bfb\u8005\u7fa4<\/div>\n<div>\u4e0e\u4e13\u4e1a\u4eba\u58eb\u96f6\u8ddd\u79bb\uff0c\u7b2c\u4e00\u65f6\u95f4\u4eab\u6709\u8d44\u8baf<\/div>\n<div>\u8fdb\u7fa4\u65b9\u6cd5\u5982\u4e0b<\/div>\n<div>\u6dfb\u52a0\u4ee5\u4e0b\u5fae\u4fe1\uff0c\u6ce8\u660e\u5355\u4f4d-\u804c\u4f4d-\u59d3\u540d\uff0c\u6dfb\u52a0\u6210\u529f\u540e\u53d1\u9001\u540d\u7247\u6216\u5355\u4f4d\u90ae\u7bb1<\/div>\n<div>\u5ba1\u6838\u901a\u8fc7\u540e\u5373\u52a0\u5165\u7fa4\u3002\u4fe1\u606f\u4e0d\u5b8c\u6574\u3001\u4e0d\u771f\u5b9e\u6216\u53d1\u9001\u8fc7\u591a\u5e7f\u544a\u548c\u65e0\u5173\u4fe1\u606f\u5c06\u8fdb\u5165\u9ed1\u540d\u5355\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/RmFicvQBAkgCIniaBVXdZJGhprQkPPCBddQxw0icic5Z3nzQluvyNB7Rpib69K5AfqwTqF0pk2fLHVuroluTUG7Zwicg\/640?wx_fmt=jpeg\" alt=\"640?wx_fmt=jpeg\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe\uff0c\u57fa\u56e0\u6167\u52a9\u624b\u5fae\u4fe1\u4e8c\u7ef4\u7801<\/div>\n<div>\u6dfb\u52a0\u5ba1\u6838\u540e\u8fdb\u5165\u57fa\u56e0\u6167\u8bfb\u8005\u7fa4\uff0c\u65b9\u6cd5\u5982\u4e0a\u3002<\/div>\n<div>\u53c2\u8003\u8d44\u6599\uff1a<\/div>\n<div>1)\u00a0Xin\u00a0Jin,\u00a0Yingwei\u00a0Chen,\u00a0Mao\u00a0Mao\u00a0et\u00a0al\uff0cIdentifying\u00a0occult\u00a0maternal\u00a0malignancies\u00a0from\u00a01.93\u00a0millionpregnant\u00a0women\u00a0undergoing\u00a0noninvasive\u00a0prenatal\u00a0screening\u00a0tests\uff0cGenetics\u00a0in\u00a0Medicine(2019)\u00a0\u00a0https:\/\/doi.org\/10.1038\/s41436-019-\u00a00510-5<\/div>\n<div>2)\u00a0Pavlidis\u00a0NA.Coexistence\u00a0of\u00a0pregnancy\u00a0and\u00a0malignancy.\u00a0Oncologist.\u00a02002;7:279\u2013287.<\/div>\n<div>3)\u00a0http:\/\/www.nmpa.gov.cn\/WS04\/CL2184\/300315.html<\/div>\n<div>4)\u00a0https:\/\/mp.weixin.qq.com\/s\/-VNq8Qhu5TdBLe-bfNX0sw<\/div>\n<div>5)\u00a0Osborne\u00a0CM,\u00a0Hardisty\u00a0E,\u00a0Devers\u00a0P,\u00a0et\u00a0al.Discordant\u00a0noninvasive\u00a0prenatal\u00a0testing\u00a0results\u00a0in\u00a0a\u00a0patient\u00a0subsequently\u00a0diagnosed\u00a0with\u00a0metastatic\u00a0disease.\u00a0\u00a0Prenat\u00a0Diagn.\u00a02013;33(6):609-611.<\/div>\n<div>6)\u00a0Bianchi\u00a0DW\u00a0et\u00a0al.\u00a0Noninvasive\u00a0Prenatal\u00a0Testing\u00a0and\u00a0Incidental\u00a0\u00a0Detection\u00a0of\u00a0Occult\u00a0Maternal\u00a0Malignancies.\u00a0Jama.\u00a02015;314(2):162-169.<\/div>\n<div>7)\u00a0Amant\u00a0F,\u00a0Verheecke\u00a0M,\u00a0etal.Presymptomatic\u00a0Identification\u00a0of\u00a0Cancers\u00a0in\u00a0Pregnant\u00a0Women\u00a0DuringNoninvasive\u00a0Prenatal\u00a0Testing.\u00a0JAMA\u00a0Oncol.\u00a02015\u00a01(6):814-9.<\/div>\n<div>8)\u00a0https:\/\/www.biorxiv.org\/content\/early\/2016\/12\/19\/095364<\/div>\n<div>\u00a0<\/div>\n<div>\u76f8\u5173\u9605\u8bfb<\/div>\n<div><a 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