{"id":9291,"date":"2019-04-18T12:00:00","date_gmt":"2019-04-18T04:00:00","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&mid=100009990&idx=1&sn=f0801ae52c806b7de59caec00a489a9b&chksm=6b715ab15c06d3a71e8108dda738657b5754b8bda663a9d59b74bd6146a88b39bfeba9221bc0#rd"},"modified":"2026-04-08T10:25:26","modified_gmt":"2026-04-08T02:25:26","slug":"5599101","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2019\/04\/18\/5599101\/","title":{"rendered":"\u57fa\u56e0\u8868\u8fbe\u8c31\u6df1\u5ea6\u5b66\u4e60\uff0c\u539f\u53d1\u7076\u4e0d\u660e\u8f6c\u79fb\u764c\u8bca\u65ad\u7684\u66d9\u5149 | \u751f\u547d\u63a2\u54e8"},"content":{"rendered":"

<\/p>\n

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\u5143\u7801\u57fa\u56e0\u8463\u4e8b\u957f&\u9996\u5e2d\u79d1\u5b66\u5bb6\u7530\u57c2\u8001\u5e08\u201c\u67095%\u7684\u80bf\u7624\u5728\u53d1\u73b0\u7684\u65f6\u5019\u5df2\u7ecf\u662f\u591a\u53d1\u8f6c\u79fb\uff0c\u73b0\u4ee3\u533b\u5b66\u5bf9\u4e0d\u540c\u539f\u53d1\u90e8\u4f4d\u80bf\u7624\u7684\u6cbb\u7597\u65b9\u6848\u662f\u4e0d\u540c\u7684\uff0c\u4e0d\u540c\u7684\u836f\u7269\u5728\u4e0d\u540c\u7684\u90e8\u4f4d\u4ea7\u751f\u7684\u6548\u679c\u4e5f\u4e0d\u5c3d\u76f8\u540c\u3002\u56e0\u6b64\uff0c\u4e86\u89e3\u80bf\u7624\u7684\u539f\u53d1\u4f4d\u7f6e\u5bf9\u6cbb\u7597\u81f3\u5173\u91cd\u8981\u201d\u00a0<\/div>\n
\u70b9\u8bc4\u4e13\u5bb6\u7b80\u4ecb<\/div>\n\n
\n
\"RmFicvQBAkgDwaz52kJOub8YicGXpHftFfIg0HOFuUJoxeXT1DLnldQ3hhSTrFatGCeQK5InhaY8vXCiaiac1FBYZA\"\/<\/figure><\/div>\n\n
\u7530\u57c2\u00a0<\/div>\n
\u5143\u7801\u57fa\u56e0\u8463\u4e8b\u957f&\u9996\u5e2d\u79d1\u5b66\u5bb6<\/div>\n
2012-2015\u5e74 \u6e05\u534e\u5927\u5b66\u57fa\u56e0\u7ec4\u4e0e\u5408\u6210\u751f\u7269\u5b66\u4e2d\u5fc3\u4e3b\u4efb\u00a0<\/div>\n
2010-2012\u5e74 \u534e\u5927\u57fa\u56e0\u534e\u5317\u7247\u533a\u8d1f\u8d23\u4eba\u00a0<\/div>\n
2007-2010\u5e74 \u6df1\u5733\u534e\u5927\u57fa\u56e0\u7814\u7a76\u9662\u6280\u672f\u5e73\u53f0\u526f\u4e3b\u7ba1\u00a0<\/div>\n
\u4e2d\u56fd\u9057\u4f20\u534f\u4f1a\u4ea7\u4e1a\u4fc3\u8fdb\u59d4\u5458\u4f1a\u526f\u4e3b\u4efb\u59d4\u5458\u00a0<\/div>\n
\u5317\u4eac\u5e02\u79d1\u59d4\u9ad8\u901a\u91cf\u6d4b\u5e8f\u9879\u76ee\u4e13\u5bb6\u00a0<\/div>\n
\u5168\u56fd\u536b\u751f\u4ea7\u4e1a\u4f01\u4e1a\u7ba1\u7406\u534f\u4f1a\u526f\u4e3b\u4efb\u59d4\u5458\u00a0<\/div>\n
\u91d1\u9e21\u6e56\u4eba\u624d\u8ba1\u5212\u79d1\u6280\u9886\u519b\u4eba\u624d\u00a0<\/div>\n
\u4e3b\u6301\u548c\u53c2\u4e0e\u591a\u9879\u56fd\u5bb6\u201c863\u201d\u201c973\u201d\u9879\u76ee\u4ee5\u53ca\u201c\u5343\u4eba\u57fa\u56e0\u7ec4\u8ba1\u5212\u201d\u7b49\u56fd\u9645\u5408\u4f5c\u9879\u76ee\uff0c\u4ee5\u901a\u8baf\u4f5c\u8005\u548c\u7b2c\u4e00\u4f5c\u8005\u5728Nature\u7b49\u56fd\u9645\u9876\u7ea7\u671f\u520a\u53d1\u8868\u8bba\u658720\u4f59\u7bc7\uff0c\u62e5\u6709\u56fd\u9645\u56fd\u5185\u4e13\u522920\u591a\u9879<\/div>\n
\u00a0<\/div>\n
\u5212\u91cd\u70b9<\/div>\n
1\uff09\u7ea65%\u00a0\u7684\u764c\u75c7\u65e0\u6cd5\u627e\u5230\u539f\u53d1\u75c5\u7076\uff0c\u88ab\u79f0\u4e3a\u539f\u53d1\u7076\u4e0d\u660e\u8f6c\u79fb\u764c\uff08CUP)\u3002<\/div>\n
2\uff09\u5bf9\u4e8e CUP \u60a3\u8005\u7684\u6cbb\u7597\u5e38\u91c7\u7528\u7684\u5e7f\u8c31\u5316\u7597\u836f\u7269\uff0c\u7f3a\u4e4f\u9488\u5bf9\u6027\uff0c\u9884\u540e\u5dee\u3002<\/div>\n
3\uff09\u764c\u79cd\u7279\u6709\u57fa\u56e0\u8868\u8fbe\u8c31\uff0c\u53ef\u8bc6\u522b\u80bf\u7624\u7684\u7ec4\u7ec7\u8d77\u6e90\u3002<\/div>\n
4\uff09RNA-seq\u57fa\u56e0\u8868\u8fbe\u8c31\uff0c\u8bc6\u522b21\u79cd\u80bf\u762453\u4e2a\u4e9a\u578b\u8d77\u6e90\uff0c\u8986\u76d690%\u7684\u5b9e\u4f53\u7624\u3002<\/div>\n
\u00a0<\/div>\n
\u4e00\u80bf\u7624\u60a3\u8005\u7684\u56f0\u6270<\/div>\n
\u4f17\u6240\u5468\u77e5\uff0c\u5728\u73b0\u6709\u764c\u75c7\u8bca\u7597\u4f53\u7cfb\u4e2d\uff0c\u660e\u786e\u539f\u53d1\u90e8\u4f4d\u4ecd\u662f\u8fdb\u884c\u6807\u51c6\u5316\u6cbb\u7597\u7684\u57fa\u7840\uff0c\u65e0\u6cd5\u627e\u5230\u539f\u53d1\u75c5\u7076\u5c06\u4f1a\u5927\u5927\u589e\u52a0\u6709\u6548\u4e34\u5e8a\u6cbb\u7597\u7684\u96be\u5ea6\uff0c\u4f46\u662f\u5927\u7ea65%\u7684\u764c\u75c7\u60a3\u8005\u90fd\u4f1a\u53d1\u751f\u8fd9\u79cd\u73b0\u8c61\uff0c\u8fd9\u7c7b\u764c\u75c7\u5c31\u79f0\u4e3a\u539f\u53d1\u7076\u4e0d\u660e\u8f6c\u79fb\u764c\uff08cancer of unknown primary, CUP)\u3002<\/div>\n
\u00a0<\/div>\n
\u4ec0\u4e48\u662f\u539f\u53d1\u7076\u4e0d\u660e\u8f6c\u79fb\u764c\uff1f<\/div>\n
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\u2460 \u539f\u53d1\u7076\u88ab\u81ea\u8eab\u673a\u4f53\u514d\u75ab\u673a\u5236\u8bc6\u522b\u3001\u653b\u51fb\uff0c\u4f7f\u539f\u53d1\u7076\u81ea\u884c\u6d88\u9000\uff1b<\/div>\n
\u2461 \u539f\u53d1\u75c5\u7076\u7ec6\u5fae\uff0c\u73b0\u884c\u7684\u68c0\u67e5\u4eea\u5668\u5c1a\u4e0d\u80fd\u53d1\u73b0\u5176\u539f\u53d1\u75c5\u7076\uff1b<\/div>\n
\u2462 \u539f\u53d1\u7076\u4f4d\u7f6e\u76f8\u5bf9\u7279\u6b8a\uff0c\u76ee\u524d\u68c0\u67e5\u624b\u6bb5\u5c1a\u4e0d\u80fd\u8fbe\u5230\u5176\u4f4d\u7f6e\uff1b<\/div>\n
\u2463 \u8d77\u521d\u539f\u53d1\u7076\u6ca1\u6709\u8868\u73b0\u51fa\u6765\uff0c\u800c\u5728\u6cbb\u7597\u7684\u8fc7\u7a0b\u4e2d\u56e0\u836f\u7269\u3001\u5c04\u7ebf\u6216\u624b\u672f\u5207\u9664\u540e\u539f\u53d1\u7076\u6d88\u5931\uff1b<\/div>\n
\u2464 \u60a3\u8005\u75c5\u7a0b\u8fdb\u5c55\u8f83\u5feb\uff0c\u8fd8\u672a\u53d1\u73b0\u539f\u53d1\u7076\u65f6\u60a3\u8005\u5373\u6b7b\u4ea1\u3002<\/div>\n
\u76ee\u524d\u5bf9\u4e8e CUP \u60a3\u8005\u7684\u6cbb\u7597\uff0c\u901a\u5e38\u91c7\u7528\u5e7f\u8c31\u5316\u7597\u836f\u7269\uff0c\u5982\u7d2b\u6749\u9187\u8054\u5408\u94c2\u7c7b\u3002\u7531\u4e8e\u7ecf\u9a8c\u6027\u5316\u7597\u7f3a\u4e4f\u9488\u5bf9\u6027\uff0c\u5316\u7597\u6548\u679c\u6b20\u4f73\uff0c\u9884\u540e\u5dee\uff0c\u5e76\u4e14\u526f\u4f5c\u7528\u8f83\u5927\uff0c\u60a3\u8005\u751f\u5b58\u8d28\u91cf\u660e\u663e\u4e0b\u964d\u3002\u4e00\u9879\u835f\u8403\u7814\u7a76\u663e\u793aCUP\u60a3\u8005\u63a5\u53d7\u5316\u7597\u540e\u4e2d\u4f4d\u751f\u5b58\u65f6\u95f4\u4e3a 4.5 \u4e2a\u6708\uff0c\u4e00\u5e74\u751f\u5b58\u7387\u4e3a 20%\uff0c\u4e94\u5e74\u751f\u5b58\u7387\u4ec5 4.7%\u3002<\/div>\n
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\u00a0<\/div>\n
\u4e8c\u3001\u7279\u6709\u57fa\u56e0\u8868\u8fbe\u8c31\uff0c\u8bc6\u522b\u80bf\u7624\u7ec4\u7ec7\u8d77\u6e90<\/div>\n
\u76ee\u524d\u4e34\u5e8a\u4e0a\u5e38\u7528\u7684CUP\u4e34\u5e8a\u8bca\u65ad\u65b9\u6cd5\u4e3a\u7ec4\u7ec7\u75c5\u7406\u5b66\u3001\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\uff08IHC\uff09\u3001\u5f71\u50cf\u5b66\u3001\u80bf\u7624\u6807\u8bb0\u7269\u3001\u5185\u955c\u7b49\u3002\u636e\u62a5\u9053\uff0c\u5373\u4f7f\u8fdb\u884c\u4e86\u6700\u5168\u9762\u7684\u5e38\u89c4\u68c0\u67e5\uff0c\u4ecd\u6709\u5927\u7ea675 %\u7684\u60a3\u8005\u65e0\u6cd5\u660e\u786e\u539f\u53d1\u7076\u3002\u8fd1\u5e74\u6765\uff0c\u968f\u7740\u5206\u5b50\u751f\u7269\u5b66\u548c\u751f\u7269\u4fe1\u606f\u5b66\u6280\u672f\u7684\u98de\u901f\u53d1\u5c55\uff0c\u4e34\u5e8a\u7814\u7a76\u53d1\u73b0\uff0c\u8f6c\u79fb\u7076\u80bf\u7624\u7684\u57fa\u56e0\u8868\u8fbe\u8c31\u4e0e\u8f6c\u79fb\u90e8\u4f4d\u7ec4\u7ec7\u7684\u57fa\u56e0\u8868\u8fbe\u8c31\u5b58\u5728\u5dee\u5f02\uff0c\u800c\u4e0e\u5176\u539f\u53d1\u90e8\u4f4d\u7ec4\u7ec7\u7684\u57fa\u56e0\u8868\u8fbe\u8c31\u66f4\u76f8\u4f3c\uff0c\u56e0\u6b64\u63d0\u793a\u80bf\u7624\u5728\u5176\u53d1\u751f\u3001\u53d1\u5c55\u3001\u8f6c\u79fb\u7684\u8fc7\u7a0b\u4e2d\uff0c\u59cb\u7ec8\u4fdd\u7559\u5176\u7ec4\u7ec7\u8d77\u6e90\u7684\u57fa\u56e0\u8868\u8fbe\u7279\u5f81\u3002Ma \u7b49\u901a\u8fc7 RT\u2043PCR \u68c0\u6d4b\u80bf\u7624\u7ec4\u7ec7\u4e2d 92 \u4e2a\u57fa\u56e0\u7684\u8868\u8fbe\u6c34\u5e73\uff0c\u5e76\u5c06 92 \u4e2a\u57fa\u56e0\u7684\u8868\u8fbe\u6a21\u5f0f\u4e0e\u6570\u636e\u5e93\u4e2d\u591a\u79cd\u764c\u75c7\u7684\u57fa\u56e0\u8868\u578b\u8fdb\u884c\u6bd4\u5bf9\uff0c\u4ece\u800c\u5224\u522b\u80bf\u7624\u539f\u53d1\u90e8\u4f4d\uff0c\u8be5\u65b9\u6cd5\u5224\u522b\u539f\u53d1\u7076\u7684\u51c6\u786e\u7387\u4e3a\u5df2\u8fbe\u5230 87% \uff0c\u5e76\u4e14\u8be5\u7814\u7a76\u5df2\u8f6c\u5316\u4e3a\u540d\u4e3aCancerTYPE ID\u00ae\u7684\u4ea7\u54c1\uff0c\u5e94\u7528\u4e8e\u4e34\u5e8a\u539f\u53d1\u7076\u4e0d\u660e\u8f6c\u79fb\u764c\u7684\u9274\u522b\u8bca\u65ad\u3002<\/div>\n\n
\n
\"RmFicvQBAkgBqGV3lRhkQwXIyGcNXE4pCDES3fudpWGhx1ola2rLSHheeEcFic5EFtuef7qpQbGv8LywFvhgCCXA\"\/<\/figure><\/div>\n\n
\u9648\u91d1\u5f71\u7b49. \u539f\u53d1\u7076\u4e0d\u660e\u8f6c\u79fb\u764c\u7684\u4e34\u5e8a\u8bca\u65ad[J]. \u5206\u5b50\u8bca\u65ad\u4e0e\u6cbb\u7597\u6742\u5fd7, 2017.<\/div>\n
\u56e0\u6b64\uff0c\u51ed\u501f\u57fa\u56e0\u8868\u8fbe\u8c31\u5206\u5b50\u6280\u672f\u8f83\u9ad8\u7684\u539f\u53d1\u7076\u68c0\u51fa\u7387\u3001\u7075\u654f\u5ea6\u548c\u7279\u5f02\u6027\uff0c\u8be5\u6280\u672f\u5c06\u6210\u4e3a\u539f\u53d1\u7076\u4e0d\u660e\u8f6c\u79fb\u764c\u9274\u522b\u8bca\u65ad\u7684\u65b0\u624b\u6bb5\u3002<\/div>\n
\u00a0<\/div>\n
\u4e09\u3001\u9488\u5bf9\u80bf\u7624\u7ec4\u7ec7\uff0c\u8ffd\u672c\u6eaf\u6e90\uff0c\u60e0\u53ca\u60a3\u8005<\/div>\n
\u56e0\u6b64\uff0c\u9488\u5bf9\u539f\u53d1\u7076\u4e0d\u660e\u8f6c\u79fb\u764c\u96be\u4ee5\u8bca\u65ad\u539f\u53d1\u7076\u7684\u56f0\u5883\uff0c\u5143\u7801\u57fa\u56e0\u7acb\u8db3\u4e8e\u8f6c\u79fb\u7076\u80bf\u7624\u7684\u57fa\u56e0\u8868\u8fbe\u8c31\u4e0e\u5176\u539f\u53d1\u90e8\u4f4d\u7ec4\u7ec7\u7684\u57fa\u56e0\u8868\u8fbe\u8c31\u76f8\u4f3c\u7684\u7814\u7a76\u7ed3\u679c\uff0c\u5229\u7528RNA-seq \u6280\u672f\u68c0\u6d4b\u767e\u4f59\u4e2a\u57fa\u56e0\uff0c\u901a\u8fc7\u5206\u6790\u57fa\u56e0\u8868\u8fbe\u8c31\uff0c\u8bc6\u522b\u5305\u62ec\u80ba\u764c\u3001\u80f0\u817a\u764c\u3001\u80c3\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u5728\u5185\u768421\u79cd\u80bf\u7624\u7684\u8d77\u6e90\uff08\u6db5\u76d653\u4e2a\u4e9a\u578b\uff0c90% \u7684\u5b9e\u4f53\u7624\uff09\u3002<\/div>\n
\u00a0<\/div>\n
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1\uff09 \u76ee\u524d\u539f\u53d1\u7076\u8bca\u65ad\u4e0d\u660e\u6216\u6709\u4e89\u8bae\u7684\u60a3\u8005\uff1b<\/div>\n
2\uff09 \u65e0\u6cd5\u660e\u786e\u75c5\u7076\u662f\u539f\u53d1\u6027\u8fd8\u662f\u8f6c\u79fb\u6027\u7684\u60a3\u8005\uff1b<\/div>\n
3\uff09 \u6709\u591a\u79cd\u764c\u75c7\u75c5\u53f2\u7684\u60a3\u8005\uff1b<\/div>\n
4\uff09 \u7b2c\u4e00\u8f6e\u514d\u75ab\u7ec4\u5316\u7ed3\u679c\u4e0d\u786e\u5b9a\uff1b<\/div>\n
5\uff09 \u4e34\u5e8a\u75c5\u53f2\u548c\u7ec4\u7ec7\u5b66\u8bca\u65ad\u4e0d\u540c\uff1b<\/div>\n
6\uff09 \u6709\u4e0d\u5178\u578b\u7684\u8f6c\u79fb\u5206\u5e03\u7684\u60a3\u8005\uff1b<\/div>\n
7\uff09 \u60a3\u8005\u5bf9\u6cbb\u7597\u6ca1\u6709\u53cd\u5e94\uff0c\u6000\u7591\u8bca\u65ad\u7ed3\u679c\uff1b<\/div>\n
8\uff09 \u80bf\u7624\u6d3b\u68c0\u6807\u672c\u6709\u9650\u6216\u5f88\u5c11\uff0c\u65e0\u6cd5\u901a\u8fc7\u5e38\u89c4\u75c5\u7406\u68c0\u6d4b\u7684\u60a3\u8005\u3002<\/div>\n
\u00a0<\/div>\n
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1.\u00a0\u83b7\u53d6\u5927\u91cf\u80bf\u7624\u60a3\u8005\u57fa\u56e0\u8868\u8fbe\u8c31\u6570\u636e\u00a0<\/div>\n
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\n
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\u88681 \u90e8\u5206\u764c\u79cd\u539f\u53d1\u7076\u6837\u672c\u4fe1\u606f<\/div>\n
2.\u00a0\u5229\u7528\u7b97\u6cd5\u8fdb\u884c\u7279\u5f81\u7b5b\u9009\u00a0<\/div>\n
\u5728\u539f\u53d1\u7076\u6570\u636e\u96c6\u4e0a\u901a\u8fc7\u968f\u673a\u68ee\u6797\uff08Random Forest\uff09\u3001\u903b\u8f91\u56de\u5f52\uff08Logistic Regression\uff09\u3001\u652f\u6301\u5411\u91cf\u673a\uff08SVM\uff09\u4e09\u79cd\u4e0d\u540c\u65b9\u6cd5\u6765\u7b5b\u9009\u5206\u7c7b\u7684\u7279\u5f81\u57fa\u56e0\u96c6\u3002\u7528\u80bf\u7624\u8868\u8fbe\u8c31\u6570\u636e\u8fdb\u884c\u6709\u76d1\u7763\u5f0f\u8bad\u7ec3\uff0c\u9009\u51fa\u6743\u91cd\u6700\u9ad8\u7684\u524dN\u4e2a\u57fa\u56e0\u4f5c\u4e3a\u5019\u9009\u7279\u5f81\u5217\u8868\u3002\u5206\u522b\u4f7f\u7528\u4e0a\u8ff0\u5019\u9009\u7279\u5f81\u91cd\u65b0\u8bad\u7ec3\u6570\u636e\u5e76\u8fdb\u884c\u6d4b\u8bd5\uff0c\u7efc\u5408\u8003\u91cf\u51c6\u786e\u6027\u548c\u57fa\u56e0\u6570\u91cf\uff0c\u6700\u7ec8\u7b5b\u9009\u51fa\u7ea6100\u4e2a\u57fa\u56e0\u7684\u7279\u5f81\u96c6\u3002<\/div>\n
\u00a0<\/div>\n
3.\u00a0\u9009\u62e9\u6700\u4f73\u7b97\u6cd5\u00a0<\/div>\n
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\u00a0<\/div>\n
4.\u00a0\u6700\u4f73\u7b97\u6cd5\u5728\u6570\u636e\u96c6\u4e0a\u7684\u53c2\u6570\u4f18\u5316\u00a0<\/div>\n
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\n
\"RmFicvQBAkgBqGV3lRhkQwXIyGcNXE4pCwicq6jyYJUXspTwAPRBhu21S2HvZ4JgGolkvSGUbqLBQE5TPvWFzklw\"\/<\/figure><\/div>\n\n
\u56fe1 ROC\u66f2\u7ebf<\/div>\n
\u6a2a\u8f74\uff1a\u5047\u9633\u6027\u7387 (false postive rate FPR) \u7279\u5f02\u5ea6\uff0c\u5212\u5206\u5b9e\u4f8b\u4e2d\u6240\u6709\u8d1f\u4f8b\u5360\u6240\u6709\u8d1f\u4f8b\u7684\u6bd4\u4f8b\uff1b(1-Specificity)<\/div>\n
\u7eb5\u8f74\uff1a\u771f\u9633\u6027\u7387 (true postive rate TPR) \u7075\u654f\u5ea6<\/div>\n
\u00a0<\/div>\n
5. \u8f6c\u79fb\u7076\u6570\u636e\u7684\u9884\u6d4b<\/div>\n
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\n
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\u88682 \u6a21\u578b\u9884\u6d4b\u8f6c\u79fb\u7076\u6570\u636e\u96c6\u7684\u7cbe\u786e\u5ea6\u4e0e\u654f\u611f\u6027<\/div>\n
6. \u4e2d\u56fd\u4eba\u7fa4\u4e34\u5e8a\u771f\u5b9e\u6837\u672c\u6d4b\u8bd5<\/div>\n
\u6536\u96c6236\u4f8b\u7ecf\u4e34\u5e8a\u8bca\u65ad\u786e\u8bca\u53d1\u751f\u8f6c\u79fb\u7684\u4e2d\u56fd\u4eba\u7fa4\u80bf\u7624\u6837\u672c\uff0c\u6bcf\u4f8b\u6837\u672c\u5747\u5305\u542b\u539f\u53d1\u7076\u548c\u5bf9\u5e94\u8f6c\u79fb\u7076\u6837\u672c\uff0c\u6db5\u76d6\u80ba\u817a\u764c\u3001\u4e73\u817a\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u5bab\u9888\u764c\u3001\u80c3\u764c\u7b49\u591a\u4e2a\u764c\u79cd\uff0c\u5e76\u5bf9\u8fd9\u4e9b\u6837\u672c\u8fdb\u884cRNA-seq\uff0c\u5c06\u83b7\u5f97\u7684\u6570\u636e\u5229\u7528\u7ec4\u7ec7\u6eaf\u6e90\u9884\u6d4b\u6a21\u578b\u8fdb\u884c\u6d4b\u8bd5\uff0c\u7ed3\u679c\u663e\u793a\u539f\u53d1\u7076\u9884\u6d4b\u51c6\u786e\u7387\u53ef\u8fbe80%\u5de6\u53f3\u3002<\/div>\n
\u00a0<\/div>\n
\u670d\u52a1\u6d41\u7a0b\uff1a<\/div>\n\n
\n
\"RmFicvQBAkgDxcrk691O20NQibvzBCjQNQ1GXf8M8m0ZaIAS0BjcOLjuibgPlpwpIhyBodvUdPrZW2ye7ib770pupw\"\/<\/figure><\/div>\n\n<\/div>\n
<\/div>\n
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\u53c2\u8003\u8d44\u6599\uff1a<\/div>\n
1\uff09\u9648\u91d1\u5f71\u7b49. \u539f\u53d1\u7076\u4e0d\u660e\u8f6c\u79fb\u764c\u7684\u4e34\u5e8a\u8bca\u65ad[J]. \u5206\u5b50\u8bca\u65ad\u4e0e\u6cbb\u7597\u6742\u5fd7, 2017.<\/div>\n
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\u7f16\u8f91\uff1aNicole<\/div>\n
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<\/div>\n
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\u76f8\u5173\u9605\u8bfb<\/div>\n
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<\/p>\n\n
\n
\"RmFicvQBAkgCgia7Hj0fX2w8ky2ULQegTyYV1StmolruZbC3NvYcjsm8z4Lib74EgWKIPPSWSaULCsju4Eic5bO8uA\"\/<\/figure><\/div>\n\n

<\/a><\/div>\n

AACR 2019\u8981\u70b9(\u4e00)\uff1a\u7cbe\u51c6\u533b\u5b66\u3001\u514d\u75ab\u6cbb\u7597\u548c\u53ef\u7a7f\u6234\u8bbe\u5907<\/a><\/p>\n

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\"RmFicvQBAkgDwDDlibn6LGMERd60A1XgibkVTEVrPEb1EoTK1HnjticKMtrzWS4eyuZgibs4H2ErBL6cp0GRTKvEAkg\"\/<\/figure><\/div>","protected":false},"excerpt":{"rendered":"

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