\n![\"RmFicvQBAkgCuC54K47siaoibvbClYbpoQdmoEA7Yo9T0l4l5c9wsK8DWv13zXvBYojNDUX4HpbxOEe8enSicCuVVg\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCuC54K47siaoibvbClYbpoQdmoEA7Yo9T0l4l5c9wsK8DWv13zXvBYojNDUX4HpbxOEe8enSicCuVVg.gif\")
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\u5173\u952e\u8bcd\uff1a\u57fa\u56e0\u548c\u5927\u5065\u5eb7 \u7528\u65f6\uff1a\u7ea65\u5206\u949f<\/div>\n
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\n\n
\n![\"RmFicvQBAkgCn7wWYTm78C1AGuNzxxAEegOkNrVZbkA6DlsehbmCfJm8LosH9MxnGztuw2Vibl3llnzia63UnwnzA\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCn7wWYTm78C1AGuNzxxAEegOkNrVZbkA6DlsehbmCfJm8LosH9MxnGztuw2Vibl3llnzia63UnwnzA.png\")
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<\/figure><\/div>\n\n\u56fe1\uff1a\u672c\u7814\u7a76\u7684\u6458\u8981\u793a\u610f\u56fe\uff0c\u6765\u81ea\u300aCell\u300b<\/div>\n
\u8fd1\u671f\u77e5\u540d\u5b66\u672f\u671f\u520a\u300aCell\u300b\u62a5\u9053\uff0c\u9ebb\u7701\u603b\u533b\u9662\uff08MGH\uff09\u57fa\u56e0\u7ec4\u533b\u5b66\u4e2d\u5fc3\u4e3b\u4efbSekar Kathiresan\u535a\u58eb\u56e2\u961f\u7814\u53d1\u4e86\u4e00\u79cd\u591a\u57fa\u56e0\u9884\u6d4b\u6a21\u578b\uff08Predictor\uff09\uff0c\u53ef\u4ee5\u9884\u6d4b\u80a5\u80d6\u6613\u611f\u6027\uff0c\u51c6\u786e\u5730\u8bf4\uff0c\u5bf9\u8d85\u8fc730\u4e07\u4ece\u5a74\u513f\u5230\u4e2d\u5e74\u4eba\u7684\u5927\u6837\u672c\uff0c\u91cf\u5316210\u591a\u4e07\u79cd\u5e38\u89c1\u57fa\u56e0\u7a81\u53d8\u4e0e\u80a5\u80d6\uff08BMI\uff09\u4e4b\u95f4\u7684\u5173\u7cfb\u3002<\/div>\n
\u4f7f\u7528\u80a5\u80d6\u9884\u6d4b\u9884\u6d4b\u6a21\u578b\u7684\u7ed3\u679c\u8868\u660e\uff0c\u6709\u4e9b\u4eba\u6bd4\u5176\u4ed6\u4eba\u66f4\u5bb9\u6613\u60a3\u80a5\u80d6\u75c7\u3002\u5f97\u5206\u5728\u524d10\uff05\u7684\u4eba\u5e73\u5747\u6bd4\u5f97\u5206\u672b10\uff05\u7684\u4eba\u5e73\u5747\u91cd29\u78c5\uff0c\u53d1\u751f\u4e25\u91cd\u80a5\u80d6\u7684\u53ef\u80fd\u6027\u9ad825\u500d\u3002<\/div>\n
\u00a0<\/div>\n
\u4e00\u80a5\u80d6\u5230\u5e95\u5bf9\u5065\u5eb7\u591a\u5927\u5371\u5bb3\uff1f<\/div>\n
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2016\u5e7412\u670827\u65e5\uff0c\u82f1\u56fd\u516c\u5171\u536b\u751f\u90e8\uff08PHE\uff09\u53d1\u5e03\u4e86\u82f1\u56fd\u5065\u5eb7\u8c03\u67e5\u7684\u6700\u65b0\u5206\u6790\u3002\u57281991-93\u52302011-13\u4e4b\u95f4\uff0c\u8d85\u91cd\u6216\u80a5\u80d6\u8005\u7684\u6bd4\u4f8b\u4ece\u7537\u6027\u768466.7\uff05\u589e\u52a0\u523076.8\uff05\uff0c\u4ece54.\u00b78\uff05\u589e\u52a0\u523063.4%\u3002\u6765\u81ea\u300a\u67f3\u53f6\u5200\u300b\u671f\u520a\u62a5\u9053[3]\u3002<\/div>\n
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\u00a0<\/div>\n
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\u8be5\u7814\u7a76\u4f7f\u7528\u5168\u57fa\u56e0\u7ec4\u98ce\u9669\u8bc4\u5206\uff08genome-wide polygenic score, GPS\uff09\uff0c\u6839\u636e\u60a3\u8005\u7684\u57fa\u56e0\u7a81\u53d8\u5c06\u60a3\u8005\u5206\u4e3a\u4e0d\u540c\u7684\u98ce\u9669\uff1a\u7c7b\u522b\u5355\u4e2a\u57fa\u56e0\u7a81\u53d8\u5f15\u8d77\u7684\u75be\u75c5\u6bd4\u8f83\u7f55\u89c1\uff1b\u66f4\u5e38\u89c1\u7684\u662f\u5305\u62ec\u5fc3\u8840\u7ba1\u75be\u75c5\uff0cII\u578b\u7cd6\u5c3f\u75c5\u548c\u90e8\u5206\u8111\u75be\u75c5\u7b49\u7531\u5e38\u89c1\u548c\u4f4e\u9891\u9057\u4f20\u53d8\u5f02\u7ec4\u5408\u5f15\u8d77\uff0c\u5176\u4e2d\u5927\u591a\u6570\u4ecd\u672a\u77e5\u3002\u6bcf\u4e2a\u57fa\u56e0\u53d8\u5f02\u7684\u5f71\u54cd\u90fd\u5f88\u5c0f\uff0c\u4f46\u662f\uff0c\u5b83\u4eec\u5408\u5728\u4e00\u8d77\u53ef\u4ee5\u663e\u793a\u4e00\u4e2a\u4eba\u7684\u6574\u4f53\u98ce\u9669\u3002<\/div>\n\n
\n![\"RmFicvQBAkgCn7wWYTm78C1AGuNzxxAEe56zKc8I1SHDicuXZO0unvx1HKJtMfFk6H6uW4XmGxrWGUjtR4Jo4A2g\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCn7wWYTm78C1AGuNzxxAEe56zKc8I1SHDicuXZO0unvx1HKJtMfFk6H6uW4XmGxrWGUjtR4Jo4A2g.png\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u56fe1\uff1a\u57fa\u4e8e\u5168\u57fa\u56e0\u7ec4\u591a\u57fa\u56e0\u8bc4\u5206\u7684\u80a5\u80d6\u98ce\u9669\u8bc4\u4f30\uff0c\u9a8c\u8bc1\u548c\u6d4b\u8bd5<\/div>\n
\u4e3a\u4e86\u521b\u5efaGPS\uff08\u5168\u57fa\u56e0\u7ec4\u98ce\u9669\u8bc4\u5206\u6a21\u578b\uff09\uff1a<\/div>\n
1\uff09\u4ece\u8fc4\u4eca\u4e3a\u6b62\u53d1\u5e03\u7684\u6700\u5927\u80a5\u80d6GWAS\u7814\u7a76\u4e2d\u83b7\u5f97\u4e86BMI\u76842,100,302\u79cd\u9057\u4f20\u53d8\u5f02\u4f53\u7684\u5e73\u5747\u6548\u5e94\u7ed3\u679c[6]<\/div>\n
2\uff09\u6839\u636eGWAS\u89c2\u5bdf\u5230\u7684\u7edf\u8ba1\u663e\u8457\u6027\u7684\u6548\u5e94\u5927\u5c0f\u548c\u5f3a\u5ea6\uff0c\u57fa\u56e0\u53d8\u5f02\u4e0e\u9644\u8fd1\u7684\u5176\u4ed6\u53d8\u5f02\u4e4b\u95f4\u7684\u76f8\u5173\u7a0b\u5ea6\u4ee5\u53ca\u53d8\u5f02\u4e0e\u975e\u53d8\u4f53\u7684\u6bd4\u4f8b\uff0c\u6765\u8c03\u6574\u53c2\u6570\uff0c\u91cd\u65b0\u52a0\u6743\u6bcf\u4e2a\u57fa\u56e0\u53d8\u5f02\u3002<\/div>\n
3\uff09\u56e0\u4e3a\u8fd9\u4e2a\u8c03\u6574\u53c2\u6570\u7684\u6700\u4f73\u9009\u62e9\u5f88\u96be\u5148\u9a8c\u5730\u77e5\u9053\uff0c\u6240\u4ee5\u6d4b\u8bd5\u4e865\u4e2a\u503c\u7684\u8303\u56f4\uff0c\u6839\u636e\u4e4b\u524dVilhj\u00e1lmsson\u7b49\u4eba\u7684\u63a8\u8350[7]\u3002<\/div>\n
4\uff09\u901a\u8fc7\u82f1\u56fd\u751f\u7269\u94f6\u884c\uff08UK Biobank\uff09\u7684119,951\u540d\u4e2d\u5e74\u6210\u4eba\u53c2\u4e0e\u8005\u7684\u9a8c\u8bc1\u6570\u636e\uff0c\u6765\u6211\u9a8c\u8bc1\u8fd95\u4e2a\u53c2\u6570\u503c\uff0c\u5e76\u901a\u8fc7\u6d4b\u8bd5\u5728\u96c6\u4e2d\u9884\u6d4bBMI\u7684\u80fd\u529b\u6765\u9009\u62e9\u8fdb\u4e00\u6b65\u5206\u6790\u7684\u6700\u4f73\u53c2\u6570\u3002<\/div>\n\n
\n![\"RmFicvQBAkgCn7wWYTm78C1AGuNzxxAEea8sAM2oKaq0w1YZ2C0SPibibF0vBxlianHCjH1T0XBUVo5691biaUDOA6w\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCn7wWYTm78C1AGuNzxxAEea8sAM2oKaq0w1YZ2C0SPibibF0vBxlianHCjH1T0XBUVo5691biaUDOA6w.png\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u56fe2\uff1a\u5168\u57fa\u56e0\u7ec4\u98ce\u9669\u8bc4\u5206\uff08GPS\uff09\u5206\u5e03\u4e0eBMI\uff0c\u4f53\u91cd\u548c\u91cd\u5ea6\u80a5\u80d6\u7684\u5173\u7cfb<\/div>\n
\u6839\u636eGPS\u5341\u5206\u4f4d\u6570\u5bf9\u4eba\u7fa4\u8fdb\u884c\u5206\u5c42\uff0c\u5e76\u53d1\u73b0\u4e86\u5173\u4e8eBMI\uff0c\u4f53\u91cd\u548c\u80a5\u80d6\u60a3\u75c5\u7387\u7684\u663e\u663e\u8457\u68af\u5ea6\uff08\u56fe2\uff09\u3002\u5728GPS\u6700\u9ad8\u5341\u5206\u4f4d\u6570\u768428,784\uff085.6\uff05\uff09\u4e2d\u67091,621\u4e2a\u5b58\u5728\u4e25\u91cd\u80a5\u80d6\uff0c\u800c\u6700\u4f4e\u5341\u5206\u4f4d\u6570\u4e3a28,834\uff080.2\uff05\uff09\u4e2d\u768469\u4e2a\uff0c\u76f8\u5f53\u4e8e\u4e25\u91cd\u80a5\u80d6\u98ce\u9669\u768425\u500d\u68af\u5ea6\uff08p <0.0001\uff09\u3002<\/div>\n
\u00a0<\/div>\n
\u4e09\u9884\u6d4b\u7ed3\u679c\u5982\u4f55\uff0c\u6211\u4eec\u53ef\u4ee5\u5b66\u5230\u4ec0\u4e48\uff1f<\/div>\n
\u591a\u57fa\u56e0\u9057\u4f20<\/div>\n
\u80a5\u80d6\u88ab\u8ba4\u4e3a\u6709\u53ef\u9057\u4f20\u7684\u6210\u5206\uff0c\u201c\u5148\u5929\u6027DNA\u53d8\u5f02\u589e\u52a0\u67d0\u4e9b\u4eba\u80a5\u80d6\u6613\u611f\u6027\uff0c\u4e5f\u4fdd\u62a4\u67d0\u4e9b\u4e2a\u4f53\u514d\u4e8e\u80a5\u80d6\u3002\u201d\u5728\u6781\u5c11\u6570\u60c5\u51b5\u4e0b\uff0c\u9057\u4f20\u5bf9\u80a5\u80d6\u7684\u6613\u611f\u6027\u53ef\u80fd\u662f\u7531\u5355\u4e2a\u57fa\u56e0\u7a81\u53d8\u5f15\u8d77\u7684\uff0c\u5982MC4R\u57fa\u56e0\uff1b\u4f46\u591a\u6570\u60c5\u51b5\uff0c\u80a5\u80d6\u7684\u9057\u4f20\u6613\u611f\u6027\u53ef\u80fd\u6e90\u4e8e\u591a\u79cd\u53d8\u5f02\u7684\u7d2f\u79ef\u6548\u5e94\uff0c\u8fd9\u548c\u5176\u4ed6\u590d\u6742\u75be\u75c5\u610f\u8bd1\u3002<\/div>\n
\u00a0<\/div>\n
0-8\u5c81\u66f4\u662f\u80a5\u80d6\u6613\u611f\u671f\u7684\u9ec4\u91d1\u65f6\u671f<\/div>\n
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\u00a0<\/div>\n
\u5206\u6570\u53ea\u662f\u9884\u6d4b\u98ce\u9669\uff0c\u4e0d\u80fd\u7528\u4e8e\u4e34\u5e8a<\/div>\n
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\u00a0<\/div>\n
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\u00a0<\/div>\n
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1. \u4ece\u79d1\u7814\u4e0a\uff0c\u8fd9\u91cc\u9664\u4e86\u7814\u7a76\u4e0d\u540c\u4eba\u7fa4\u5f02\u8d28\u6027\u5916\uff0c\u5bf9\u4e8e\u7236\u4eb2\u548c\u6bcd\u4eb2\u7684\u5728\u80a5\u80d6\u65b9\u9762\u7684\u4e0d\u540c\u9057\u4f20\u6548\u5e94\u53ef\u4ee5\u4f5c\u4e3a\u4e00\u4e2a\u7ef4\u5ea6\uff1b\u540c\u65f6\uff0c\u9664\u4e86\u591a\u57fa\u56e0\u7684\u9057\u4f20\u56e0\u7d20\uff0c\u540e\u5929\u7684\u5fae\u73af\u5883\u53ef\u4ee5\u4f5c\u4e3a\u56e0\u6216\u679c\u7684\u5173\u8054\u7814\u7a76\u3002\u4e4b\u524d\u6709\u8fc7\u4e0d\u5c11\u62a5\u9053\uff0c\u6b64\u5904\u4e0d\u505a\u8d58\u8ff0\u3002P.S. \u672c\u4eba\u662f\u201d\u5e72\u5403\u4e0d\u80d6\u201c\u7684\u7c7b\u578b\uff0c\u82e6\u4e8e\u589e\u80a5\u65e0\u6548\uff08\u6b64\u5904\u53ef\u80fd\u542c\u5230\u6254\u9e21\u86cb\u58f0\uff09\uff0c\u4e00\u76f4\u4ee5\u6765\u5bf9\u201d\u57fa\u56e0+\u80a0\u9053\u5fae\u751f\u7269\u201d\u4e0e\u80a5\u80d6\u7684\u5173\u7cfb\u53ca\u5e72\u9884\u611f\u5174\u8da3\u4e5f\u6709\u4ea7\u54c1\u9700\u6c42\uff0c\u5982\u679c\u5408\u9002\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u53ef\u8d21\u732e\u591a\u7ec4\u5b66\u771f\u5b9e\u6837\u672c\u3002<\/div>\n
2. \u4ece\u6280\u672f\u8f6c\u5230\u4ea7\u54c1\u4e0a\uff0c\u4e5f\u8bb8\u56fd\u5185DTC\uff08\u76f4\u63a5\u9762\u5411\u6d88\u8d39\u8005\uff09\u57fa\u56e0\u68c0\u6d4b\u4f01\u4e1a\u4f1a\u8003\u8651\u589e\u52a0\u6216\u66f4\u65b0\u80a5\u80d6\u9884\u6d4b\u6a21\u578b\uff0c\u6ee1\u8db3\u5f53\u4e0b\u5207\u5b9e\u9700\u6c42\u3002\u7279\u522b\u662f\u5bf9\u4e8e\u65b0\u751f\u513f\u7684\u5bb6\u5ead\u5065\u5eb7\u7ba1\u7406\u573a\u666f\u3002\u8fd9\u91cc\u9700\u8981\u4f01\u4e1a\u7ba1\u7406\u8005\/\u6295\u8d44\u8005\u6574\u5408\u57fa\u56e0\u4e4b\u5916\u7684\u591a\u7ec4\u5b66\u8d44\u6e90\u53ca\u5bf9\u4e8e\u8f83\u957f\u65f6\u671f\u4ea7\u51fa\u7684\u8010\u5fc3\u3002\u6240\u4ee5\uff0c\u521b\u6295DTC\u76c8\u5229\u8005\u5c5e\u4e8e\u4e2d\u957f\u671f\u4e0d\u4e0b\u724c\u684c\u4e14\u6d3b\u7740\u7684\u4eba\u3002<\/div>\n
3. \u4ece\u4ea7\u4e1a\u4e0a\uff0c\u56fd\u5185\u9664\u4e86\u719f\u77e5\u7684DTC\u4f01\u4e1a\u5305\u62ec23\u9b54\u65b9\u3001WeGene\u3001\u6c34\u6bcd\u57fa\u56e0\u4e4b\u5916\uff0c \u6570\u5341\u5bb6\u4f01\u4e1a\u6d89\u730e\uff08\u4ee3\u7406\u548c\u4e8c\u4e09\u7ebf\u57ce\u5e02\u6982\u5ff5\u7092\u4f5c\u5546\u4e0d\u7b97\uff09\uff0c\u5305\u62ec\u8d1d\u745e\u57fa\u56e0\uff08\u00a0000710.SZ\uff09\u65d7\u4e0b\u7684\u5706\u57fa\u56e0\u5f00\u4e1a\u9080\u8bf7\u4e86\u6881\u548f\u742a\u7b49\u4e00\u7ebf\u660e\u661f\u52a9\u9635\uff0c\u80bf\u7624\u6db2\u4f53\u6d3b\u68c0\u4f01\u4e1a\u6d77\u666e\u6d1b\u65af\u4f4e\u8c03\u521b\u7acb\u4e86\u201c\u5c0f\u6d77\u7801\u57fa\u56e0\u201d\u54c1\u724c\u3002\u800c\u534e\u5927\u57fa\u56e0\uff08300676.SZ\uff09\u5728\u6295\u8d44\u77e5\u56e0\u76d2\u5b50\u5916\uff0c\u4e5f\u6295\u8d44\u4e86WeGene\u3002\u8fc7\u53bb\u4e24\u5e74Player\u4e4b\u95f4\u7684\u7ade\u4e89\u6a21\u5f0f\u662f\u4ef7\u683c\u6218\uff0c\u76ee\u524d\u8d70\u91cd\u4f53\u91cf\u5316\u548c\u8de8\u754c\u5927\u4f17\u5a31\u4e50\u6e20\u9053\u3002\u5bf9\u6bd4\u7f8e\u56fd\u57fa\u56e0\u5de8\u5934Illumina\uff0c\u6295\u8d44\u521b\u5efa\u4e86Helix\u5e73\u53f0\u5f0fDTC\u4f01\u4e1a\uff0c\u521d\u59cb\u5316\u5c31\u5305\u62ec\u4e86\u79fb\u52a8\u624b\u73af\u3001\u8425\u517b\u5e72\u9884\u3001\u6587\u5316\u521b\u610f\u7c7b\u4f01\u4e1a\u548c\u4ea7\u54c1\u5f00\u653e\u5f0f\u5408\u4f5c\u3002\u8fd9\u4e0e\u4f01\u4e1a\u6587\u5316\u548c\u6295\u8d44\u6587\u5316\u76f8\u5173\u3002\u540e\u8005\u7684\u6a21\u5f0f\u53ef\u80fd\u662f\u56fd\u5185DTC\u5de8\u5934\u7684\u5f52\u5bbf\u3002<\/div>\n
4. \u4ece\u653f\u7b56\u51b3\u7b56\u4e0a\uff0c\u671f\u671b\u8fd9\u7bc7\u6587\u7ae0\u4e2d\u7684\u7814\u7a76\u53ef\u4ee5\u7ed9\u56fd\u5185DTC\u653f\u7b56\u5236\u5b9a\u63d0\u4f9b\u53c2\u8003\u3002\u4e00\u65b9\u9762\uff0cDTC\u5bf9\u4e8e\u5927\u5065\u5eb7\u5e94\u7528\u573a\u666f\u5e7f\u9614\uff08\u5927\u4e8e\u4e34\u5e8a\uff09\uff0c\u9700\u5c3d\u5feb\u5236\u5b9a\u6307\u5357\u6216\u521d\u6b65\u51b3\u7b56\uff0c\u4ee5\u514d\u4fe1\u606f\u4e0d\u5bf9\u79f0\u53ef\u80fd\u5e26\u6765\u57fa\u56e0\u884c\u4e1a\u7684\u201c\u9b4f\u5219\u897f\u4e8b\u4ef6\u201d\uff1b\u53e6\u4e00\u65b9\u9762\uff0c\u5728\u6a21\u5f0f\u5efa\u6784\u4e2d\u9700\u8981\u4e34\u5e8a\u6765\u5efa\u7acb\u8bca\u65ad\u6807\u51c6\uff0c\u540c\u65f6\u4e5f\u9700\u8981\u62d3\u5bbd\u601d\u7ef4\u4ee5\u5927\u6837\u672c\u548c\u591a\u7ec4\u5b66\u7814\u7a76\u7684\u65b0\u601d\u8def\uff0c\u76f4\u53d6\u516c\u5171\u536b\u751f\u7684\u5065\u5eb7\u9884\u9632\u6807\u51c6\u3002\u5f53\u7136\uff0c\u8fd9\u70b9\u548c\u7b2c3\u70b9\u7c7b\u4f3c\u3002\u613f\u666f\u548c\u5b9e\u8df5\u4e4b\u95f4\uff0c\u9700\u8981\u8d44\u672c\u3001\u4ea7\u4e1a\u94fe\u548c\u4ea7\u4e1a\u8054\u76df\u7684\u63a8\u8fdb\uff0c\u975e\u72ec\u5bb6\u4f01\u4e1a\u80fd\u4e3a\u3002\u6211\u4eec\u5728\u4ea7\u4e1a\u7814\u7a76\u3001\u5e02\u573a\u8c03\u7814\u548c\u57f9\u8bad\u4e0a\u53ef\u53c2\u4e0e\u5408\u4f5c\u3002<\/div>\n
\uff08\u6ce8\uff1a\u4ee5\u4e0a\u4ec5\u4ee3\u8868\u4f5c\u8005\u6216\u7f16\u8005\u89c2\u70b9\uff0c\u4ec5\u4f9b\u5b66\u672f\u63a2\u8ba8\uff0c\u4e0d\u4ee3\u8868\u5e73\u53f0\u5b98\u65b9\u610f\u89c1\u548c\u6295\u878d\u8d44\u7b49\u51b3\u7b56\u4f9d\u636e\uff09<\/div>\n
\u00a0<\/div>\n
\u53c2\u8003\u8d44\u6599\uff1a<\/div>\n
1\uff09Amity V.Khera et al. Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood, Cell\uff082019\uff09, VOLUME 177, ISSUE 3, P587-596.E9<\/div>\n
2\uff09Julianna Lemieux, Sophia Ktori\uff0cGenetic Basis of Obesity Carries Weight<\/div>\n
3\uff09Obesity and diabetes in 2017: a new year, The Lancet<\/div>\n
4\uff09Health Effects of Overweight and Obesity in 195 Countries over 25 Years The GBD 2015 Obesity Collaborators\uff0cN Engl J Med 2017; 377:13-27<\/div>\n
5) Sudlow C. et al. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 2015; 12: e1001779<\/div>\n
6) Locke A.E et al. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015; 518: 197-206<\/div>\n
7)\u00a0Vilhj\u00e1lmsson B.J. et al. Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores. Am. J. Hum. Genet. 2015; 97: 576-592\u00a0<\/div>\n
\u00a0<\/div>\n
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100+\u5bb6\u57fa\u56e0\u68c0\u6d4b\u673a\u6784\u53c2\u4e0e| \u7b2c\u4e8c\u5c4a\u57fa\u56e0\u68c0\u6d4b\u8054\u76df\u4f1a\u8bae<\/a><\/div>\n
193\u4e07\u5b55\u5987\u65e0\u521b\u4ea7\u524d\u57fa\u56e0\u7b5b\u67e5\u53d1\u73b0\u5b55\u671f\u80bf\u7624<\/a><\/div>\n
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\n![\"RmFicvQBAkgDJkslCjQ2eianQraykAic9cibUichkIGia8EuLp3BVEkck3PVXluOAXw8KiciaicupVhsldIek3LTFOgChcg\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDJkslCjQ2eianQraykAic9cibUichkIGia8EuLp3BVEkck3PVXluOAXw8KiciaicupVhsldIek3LTFOgChcg.png\")
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\u884c\u4e1a\u7814\u7a76\u5458<\/div>\n
\u65b0\u5a92\u4f53\u7f16\u8f91<\/div>\n
\u3010\u52a0\u5165\u57fa\u56e0\u6167\u3011info@genonet.cn<\/div>\n
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\n![\"640?wx_fmt=jpeg\"\/](\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/RmFicvQBAkgCIniaBVXdZJGhprQkPPCBddQxw0icic5Z3nzQluvyNB7Rpib69K5AfqwTqF0pk2fLHVuroluTUG7Zwicg\/640?wx_fmt=jpeg\")
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