{"id":9285,"date":"2019-05-08T17:22:36","date_gmt":"2019-05-08T09:22:36","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&#038;mid=100010101&#038;idx=1&#038;sn=d80cf462c7485fa88ee232d2113fe5cc&#038;chksm=6b715ac25c06d3d44138e6cd8600a395ce9907b752fc9a8e425edd26426841a572c5c040faac#rd"},"modified":"2026-04-08T10:24:18","modified_gmt":"2026-04-08T02:24:18","slug":"569756","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2019\/05\/08\/569756\/","title":{"rendered":"\u521b\u65b0\u548c\u7834\u5c40 | \u7b2c\u516d\u5c4aNGS\u521b\u65b0\u5f00\u53d1\u8005\u5927\u4f1a\u8bb0\u5b9e"},"content":{"rendered":"<p><!-- wechat_content_hash: 8a804dc4768dd84e --><\/p>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCuC54K47siaoibvbClYbpoQdmoEA7Yo9T0l4l5c9wsK8DWv13zXvBYojNDUX4HpbxOEe8enSicCuVVg.gif\" 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\u6587\/\u57fa\u56e0\u6167<\/div>\n<div>\u6cdbN\u00b7GS\uff0c\u6307\u7684\u662f\u57fa\u56e0\u68c0\u6d4b\u6280\u672f\uff0c\u5305\u62ec\u6d4b\u5e8f\u3001\u82af\u7247\u3001\u8d28\u8c31\u3001\u56fe\u8c31\u7b49\u6280\u672f\u30022010\u5e74\u524d\u540e\u7684\u4ea7\u4e1a\u5316\uff0c2015-2016\u7684\u8d44\u672c\u8ffd\u6367\u540e\uff0c2018-2020\u5e74\u8fdb\u5165\u6dd8\u6d17\u7684\u9636\u6bb5\u3002\u5728\u884c\u4e1a\u548c\u6280\u672f\u6210\u4e3a\u56fd\u5bb6\u6218\u7565\u7684\u8d8b\u52bf\u4e0b\uff0c\u4ea7\u4e1a\u9762\u4e34\u4ea7\u91cf\u548c\u5e94\u7528\u53d8\u73b0\u7684\u6311\u6218\uff0c\u800c\u4e34\u5e8a\u5bf9\u4ea7\u4e1a\u7684\u8d28\u7591\u548c\u6e34\u671b\u5e76\u5b58\u3002\u8fd9\u6837\u7684\u65f6\u673a\uff0c2019\u5e74\u7b2c\u516d\u5c4aNGS\u521b\u65b0\u5f00\u53d1\u8005\u5927\u4f1a\u4e8e4\u670826-27\u65e5\u5728\u94b1\u5858\u6c5f\u7554\u53ec\u5f00\uff0c\u4f1a\u8bae\u671f\u95f4\u4e5f\u4e3e\u884c\u4e86\u201c\u53d1\u73b0\u5f00\u53d1\u8005\u201d\u7684\u8def\u6f14\u4ee5\u53ca\u987e\u5927\u592b\u6c99\u9f99\u7b49\u6d3b\u52a8\u3002\u57fa\u56e0\u6167\u68b3\u7406\u5982\u4e0b\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u4e00\u4f1a\u8bae\u7ec4\u7ec7\u65b9<\/div>\n<div>\u4e3b\u529e\u65b9<\/div>\n<div>\u57fa\u4e91\u60e0\u5eb7<\/div>\n<div>\u4e2d\u56fd\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u5b66\u4f1a\u533b\u5b66\u68c0\u9a8c\u5de5\u7a0b\u5206\u4f1a<\/div>\n<div>\u627f\u529e\u65b9<\/div>\n<div>NGS\u521b\u65b0\u5f00\u53d1\u8005\u534f\u4f1a<\/div>\n<div>\u627f\u529e\u5355\u4f4d<\/div>\n<div>HGBC<\/div>\n<div>\u8d1d\u58f3\u65f6\u4ee3<\/div>\n<div>\u500d\u6570\u8d44\u672c<\/div>\n<div>\u8d1d\u58f3\u793e<\/div>\n<div>\u987e\u5927\u592b\u5de5\u4f5c\u5ba4<\/div>\n<div>\u534e\u5927\u667a\u9020<\/div>\n<div>\u00a0<\/div>\n<div>\u4e8c\u4e3b\u9898\u62a5\u544a<\/div>\n<div>\u5728\u4e3b\u9898\u62a5\u544a\u73af\u8282\uff0c\u590d\u65e6\u5927\u5b66\u7684\u4e8e\u6587\u5f3a\u6559\u6388\u3001\u534e\u5927\u667a\u9020\u7684\u738b\u5a01\u535a\u58eb\u3001\u54c8\u4f5b\u5927\u5b66RRBS\u6280\u672f\u53d1\u660e\u4eba\u8c37\u7ea2\u4ed3\u6559\u6388\u3001\u5e7f\u5dde\u533b\u79d1\u5927\u5b66\u7684\u8303\u52c7\u7814\u7a76\u9662\u7b49\u9610\u8ff0\u4e86\u6700\u65b0\u7684\u6280\u672f\u8fdb\u5c55\u3002\u90e8\u5206\u5185\u5bb9\u68b3\u7406\u5982\u4e0b\uff08\u6309\u7167\u6f14\u8bb2\u987a\u5e8f\uff09\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u4e8e\u6587\u5f3a \u590d\u65e6\u5927\u5b66\u751f\u7269\u533b\u5b66\u7814\u7a76\u9662\u7814\u7a76\u5458<\/div>\n<div>\u300aGPS\u68c0\u6d4bDNA\u7532\u57fa\u5316\u300b<\/div>\n<div>1\uff09\u5168\u57fa\u56e0\u7ec4DNA\u7532\u57fa\u5316\u68c0\u6d4b\u7684\u5c40\u9650\u6027\uff0c\u9664\u4e86\u4ef7\u683c\u8f83\u8d35\uff0c\u6bd4\u5bf9\uff08Mapping\uff09\u662f\u74f6\u9888\uff0cGPS\u6280\u672f\u53ef\u4ee5\u63d0\u9ad8Map\u6bd4\u5bf9\u7387\uff0886%\uff09\uff0c\u5747\u4e00\u6027\u548c\u51c6\u786e\u6027\uff0c\u540c\u65f6\u6709\u52a9\u4e8e\u7ed8\u5236\u764c\u75c7\uff08\u6bd4\u5982\u809d\u764c\uff09\u7532\u57fa\u5316\u56fe\u8c31\uff08\u8986\u76d696%\uff09\u3002\u57fa\u4e8e\u7126\u78f7\u9178\u6d4b\u5e8f\uff0c5\u4e2a\u5c0f\u65f6\u51fa\u7ed3\u679c\u3002<\/div>\n<div>2\uff09\u57fa\u4e8eGPS\u7684\u62d3\u5c55\u5305\u62ec\uff1a A.\u9884\u6d4b\u57fa\u56e0\u8868\u8fbe\uff08\u7b80\u79f0MeDGP\u65b9\u6cd5\uff09; B.\u8fdb\u884c\u80bf\u7624\u514d\u75ab\u76d1\u6d4b\uff1bC.\u901a\u8fc7\u589e\u5f3a\u5b50\u6f02\u79fb\u5224\u65ad\u7ec6\u80de\u8eab\u4efd\u8f6c\u53d8\uff0c\u8fdb\u884c\u76d1\u6d4b\u80bf\u7624\u8f6c\u79fb\uff1bD.\u786e\u5b9a\u4e0d\u540c\u80bf\u7624\u5171\u540c\u6807\u5fd7\u7269\uff0c\u68c0\u6d4bctDNA\u7532\u57fa\u5316\u3001\u80ba\u764c\u704c\u6d17\u6db2\u4e2dCTSM DNA\u7532\u57fa\u5316\u3001\u80bf\u7624\u7597\u6548\u7684\u5224\u5b9a\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u738b\u5a01\uff0c\u534e\u5927\u667a\u9020\u526f\u603b\u88c1\u3001\u7814\u7a76\u5458<\/div>\n<div>\u300a\u957f\u8bfb\u957f\u3001\u77ed\u8bfb\u957f\u4e0e\u78b1\u57fa\u8bc6\u522b\u300b<\/div>\n<div>1\uff09\u6d4b\u5e8f\u6280\u672f\u7684\u6838\u5fc3\u8981\u7d20\uff1a\u51c6\u786e\u6027\u3001\u901f\u5ea6\u3001\u901a\u91cf\u3001\u7a33\u5b9a\u6027\u3001\u6210\u672c\u3002\u6d4b\u5e8f\u6280\u672f\u7684\u53d1\u5c55\uff0c\u4ece\u524d\u76f4\u8bfb\u3001\u76f4\u8bfb\u3001\u81ea\u52a8\u5316\u3001\u89c4\u6a21\u5316\u3001\u9ad8\u901a\u91cf\u6d4b\u5e8f\u5230\u5355\u5206\u5b50\u3002<\/div>\n<div>2\uff09\u9ad8\u901a\u91cf\u6d4b\u5e8f\uff08MPH\uff09\u7528\u727a\u7272\u8bfb\u957f\u6765\u63d0\u9ad8\u901a\u91cf\u3002\u957f\u8bfb\u957f\u5728\u91cd\u590d\u533a\u57df\u7684\u68c0\u6d4b\u3001\u62f7\u8d1d\u6570\u7ed3\u6784\u53d8\u5f02\u3001\u57fa\u56e0\u8f6c\u5f55\u672c\u68c0\u6d4b\u3001\u5355\u4f53\u578b\u4fe1\u606f\u4ee5\u53caDenovo\u57fa\u56e0\u7ec4\u4e0e\u8f6c\u5f55\u7ec4\u7ec4\u88c5\u65b9\u9762\u6709\u4f18\u52bf\u540c\u65f6\u5b58\u5728\u51c6\u786e\u6027\u548c\u6210\u672c\u7b49\u95ee\u9898\u3002<\/div>\n<div>3\uff09\u878d\u5408\u4e8c\u8005\u7684\u89e3\u51b3\u65b9\u6848\uff0c\u957f\u8bfb\u957f\u548c\u77ed\u8bfb\u957f\u6d4b\u5e8f\u6280\u672f\u7ed3\u5408\u4f7f\u7528\uff0c\u5408\u6210\u957f\u8bfb\u5e8f\u5217\u3002MGI\u57fa\u4e8e\u540e\u8005\u5f00\u53d1\u4e86StLFR\uff08\u5355\u7ba1\u957f\u8bfb\u7247\u6bb5\u6280\u672f\uff09\uff0c\u6838\u5fc3\u662f\u5bf9\u5efa\u5e93\u4e2d\u957f\u5206\u5b50\u8fdb\u884c\u6807\u8bb0barcode\uff0c\u7136\u540e\u8fdb\u884c\u7ec4\u88c5\uff0c\u96cf\u5f62\u6765\u6e90\u4e8eLFR\u6280\u672f\u3002\u901a\u8fc7\u7236\u6bcd stLFR\u57fa\u56e0\u7ec4+cfDNA\u6765\u4e86\u89e3\u80ce\u513f\u5b8c\u6574\u57fa\u56e0\u7ec4\uff0c\u51c6\u786e\u6027\u8fbe93.7%\uff0c\u57fa\u56e0\u578b\u51c6\u786e\u6027\u8fbe99.6%\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u8c37\u7ea2\u4ed3\uff0c\u54c8\u4f5b\u5927\u5b66&amp;MIT Broad Institute \u5ba2\u5ea7\u8bb2\u6388\u3001RRBS\u53d1\u660e\u4eba<\/div>\n<div>\u300a\u5355\u7ec6\u80de\u7532\u57fa\u5316\u548c\u8f6c\u5f55\u7ec4RRBS-SMART\u6280\u672f\u5728\u5e72\u7ec6\u80de\u548c\u80bf\u7624\u7ec6\u80de\u6f14\u5316\u4e2d\u7684\u5e94\u7528\u300b<\/div>\n<div>\uff08\u6ce8\uff1a\u8c37\u6559\u6388\u521a\u5165\u804c\u6d59\u6c5f\u5723\u5ead\u751f\u7269\uff0c\u62c5\u4efbCSO\u548c\u8463\u4e8b\uff09<\/div>\n<div>1\uff09RRBS \u6700\u5927\u7684\u7279\u70b9\u662f\u6bd4\u5bf9\u7387\u8f83\u9ad8\uff1bDNA\u7528\u91cf\u4ece\u6700\u521d\u768410\u5fae\u514b\u964d\u4f4e\u523030\u7eb3\u514b\uff0c\u5982\u679c\u9009\u62e940-220BP\u7684\u7247\u6bb5\uff0c\u5bf9CpG\u5c9b\u7684\u5bcc\u96c6\uff0c\u5bf9\u8001\u9f20\u662f50\u500d\u30022017\u5e74\u7684\u65f6\u5019\uff0c\u6211\u4eec\u628aRRBS\u53c8\u548cSMART\u7ed3\u5408\u5230\u4e00\u8d77\uff0c\u5bf9\u540c\u4e00\u4e2a\u6837\u672c\u540c\u65f6\u68c0\u6d4b\uff0c\u53ef\u4ee5\u6d4b\u5355\u7ec6\u80de\u3002<\/div>\n<div>2\uff09RRBS\u68c0\u6d4b\u540c\u4e00\u7ec6\u80de\u7684\u57fa\u56e0\u7ec4\u7532\u57fa\u5316\u4f11\u606f\u548c\u5168\u57fa\u56e0\u8868\u8fbe\uff0c\u5e94\u7528\u4e8e\u6162\u6027\u6dcb\u5df4\u767d\u8840\u75c5\u7684\u8868\u89c2\u9057\u4f20\u6f14\u5316\u548c\u9057\u4f20\u56fe\u8c31\uff0c\u5728\u5355\u7ec6\u80de\u6d4b\u5e8f\u4e2d\u53d1\u73b0\u80bf\u7624\u7ec6\u80de\u8d77\u6e90\u6a21\u5f0f\u3001\u76d1\u6d4b\u7a81\u53d8\u65f6\u95f4\u548c\u8fdb\u5ea6\u3001\u8fa8\u522bdriver variant\u3001\u7528\u4e8e\u80bf\u7624\u836f\u7269\u7b5b\u9009\u7b49\u3002\u6211\u4eec\u548c\u54c8\u4f5b\u533b\u5b66\u9662\u5408\u4f5c\uff0c\u6d4b\u4e862000\u591a\u4e2a\u6162\u6dcb\uff08\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u6027\u767d\u8840\u75c5\uff09\u548c\u6b63\u5e38B\u7ec6\u80de\uff0c\u7136\u540e\u8fdb\u884c\u5bf9\u6bd4\u5bfb\u627e\u8868\u89c2\u7a81\u53d8\u89c4\u5f8b\u3002\u53ef\u4ee5\u770b\u5230\u5927\u5bb6\u53ef\u4ee5\u770b\u6162\u6dcbB\u7ec6\u80de\u8868\u89c2\u7a81\u53d8\u7387\u6bd4\u653f\u7b56 B \u7ec6\u80de\u5feb\u5f97\u591a\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u6768\u8f89\u535a\u58eb\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u795e\u7ecf\u6240\u7814\u7a76\u5458<\/div>\n<div>\u300a\u5355\u78b1\u57fa\u57fa\u56e0\u7f16\u8f91\u5b89\u5168\u6027\u8bc4\u4ef7\u300b<\/div>\n<div>1\uff09\u5386\u53f2\u68b3\u7406\uff1a<\/div>\n<div>A. \u4ece\u7b2c\u4e00\u4ee3\u7684\u805a\u5408\u9176\uff0c\u5b83\u53ef\u4ee5\u5bf9DNA\u8fdb\u884c\u5207\u5272\uff0c\u4f46\u8bc6\u522b\u7684\u4f4d\u70b9\u975e\u5e38\u7684\u5c40\u9650\u6240\u4ee5\u5bf9\u4e8e\u7edd\u5927\u591a\u6570\u75be\u75c5\u90fd\u6ca1\u6709\u4efb\u4f55\u4f5c\u7528\u3002<\/div>\n<div>\u00a0<\/div>\n<div>B. \u5230\u4e862005\u5e74\uff0c\u771f\u6b63\u73b0\u4ee3\u610f\u4e49\u4e0a\u7b2c\u4e00\u4ee3\u7684\u57fa\u56e0\u7f16\u8f91\uff0c\u5c31\u662f\u950c\u6307\u9176\uff0c\u5b83\u901a\u8fc7\u86cb\u767d\u540c\u6e90\u7684\u7ed3\u6784\uff0c\u8bc6\u522b\u4e0d\u540c\u7684\u4f4d\u70b9\uff0c\u4f46\u5b83\u9700\u8981\u4e0d\u540c\u7684\u86cb\u767d\u7ed3\u6784\u624d\u80fd\u8bc6\u522b\u4e0d\u540c\u7684\u4f4d\u70b9\uff0c\u975e\u5e38\u590d\u6742\u3002<\/div>\n<div>C. \u76f4\u5230CRISPR\u51fa\u6765\u4ee5\u540e\uff0c\u51e0\u4e4e\u6bcf\u4e2a\u5b9e\u9a8c\u5ba4\u90fd\u53ef\u4ee5\u505a\uff0c\u56e0\u4e3a\u8bc6\u522b\u7684\u529f\u80fd\u548c\u5207\u5272\u7684\u529f\u80fd\u4e00\u5207\u4e3a\u4e8c\uff0c\u8fd8\u53ef\u4ee5\u591a\u4f4d\u70b9\uff0c\u4f46\u662f\u4ecd\u7136\u9700\u8981DNA\u53cc\u94fe\u65ad\u88c2\uff0c\u800c\u4e14\u9700\u8981DNA\u6a21\u677f\uff0c\u8981\u8003\u8651DNA\u53cc\u94fe\u65ad\u88c2\u3001\u67d3\u8272\u4f53\u6613\u4f4d\u7b49\u95ee\u9898\u3002<\/div>\n<div>D. 2016\u5e74\uff0c\u54c8\u4f5b\u5927\u5b66\u4e00\u4f4d\u6559\u6388\u53d1\u73b0\u4e86\u7b2c\u56db\u4ee3\u57fa\u56e0\u7f16\u8f91\u6280\u672f\uff0c\u5373\u5355\u78b1\u57fa\u7f16\u8f91\u3002\u5b83\u4e00\u4e0d\u9700\u8981DNA\u53cc\u94fe\u65ad\u88c2\uff0c\u4e8c\u4e0d\u9700\u8981\u4fee\u590d\u6a21\u677f\uff0c\u76f4\u63a5\u628a\u6838\u9178\u9176\u7a81\u53d8\uff0c\u7136\u540e\u878d\u5408\u4e00\u4e2a\u7aef\u53e3\uff0c\u8fd9\u4e2a\u7aef\u53e3\u7684\u4f5c\u7528\u5c06C\u53d8\u6210M\uff0c\u76f8\u4e92\u8f6c\u6362\uff0c\u4e0d\u9700\u8981\u901a\u8fc7\u5316\u5b66\u4fee\u9970\u5c06\u4e00\u4e2a\u78b1\u57fa\u53d8\u6210\u4e00\u4e2a\u78b1\u57fa\uff0c\u4e5f\u4e0d\u9700\u8981\u6a21\u677f\u5207\u5272\u3001\u66ff\u6362\u548c\u4fee\u590d\uff0c\u975e\u5e38\u9ad8\u6548\u3002<\/div>\n<div>2\uff09\u57fa\u56e0\u836f\uff1a\u201c\u57fa\u56e0\u836f\u201d\u7684\u4f20\u7edf\u65b9\u5f0f\u662f\u901a\u8fc7\u75c5\u6bd2\u7684\u65b9\u5f0f\u5bfc\u5165\u7684\u57fa\u56e0\uff0c\u4f46\u7ecf\u5e38\u4f1a\u4ea7\u751f\u6297\u4f53\uff0c\u9700\u8981\u6362\u4e00\u79cd\u8840\u6e05\u578b\u7684\u75c5\u4f53\u3002\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u51fa\u6765\u540e\uff0c\u4f3c\u4e4e\u5927\u5bb6\u90fd\u627e\u5230\u4e00\u79cd\u76f8\u5bf9\u5b8c\u7f8e\u7684\u65b9\u5f0f\uff0c\u57fa\u56e0\u7a81\u53d8\u4e4b\u540e\uff0c\u76f4\u63a5\u7528CRISPR-Cas9\u4fee\u590d\u3002\u4f46\u4e5f\u5e26\u6765\u4e00\u5b9a\u7684\u9690\u60a3\uff0c\u56e0\u4e3a\u5b83\u975e\u5e38\u7684\u6d3b\u8dc3\uff0c\u4e00\u65e6DNA\u5f15\u5165\u4e86\u201c\u4e0d\u597d\u7684\u201d\u7a81\u53d8\uff0c\u5bf9\u60a3\u8005\u4e5f\u662f\u7ec8\u751f\u7684\u3002<\/div>\n<div>3\uff09\u5355\u78b1\u57fa\u7684\u6280\u672f\u4e0d\u4ea7\u751fDNA\u53cc\u94fe\u65ad\u88c2\uff0c\u4e4b\u524d\u90fd\u8ba4\u4e3a\u5b83\u662f\u975e\u5e38\u5b89\u5168\u7684\uff0c\u4f46\u5b83\u53c8\u662f\u4e00\u4e2a\u8131\u6c28\u9176\uff0c\u672c\u8eab\u6709\u81f4\u764c\u98ce\u9669\u3002\u6240\u4ee5\u6211\u4eec\u5efa\u7acb\u4e86\u4e00\u4e2a\u65b0\u7684\u8131\u9776\u68c0\u6d4b\u4f53\u7cfb\uff0c\u6700\u5927\u7684\u7279\u70b9\u662f\u57fa\u56e0\u80cc\u666f\u5b8c\u5168\u4e00\u81f4\uff0c\u7f16\u8f91\u540e\uff0c\u4e0d\u505a\u4f53\u5916\u57fa\u56e0\u7ec4\u6269\u589e\uff08\u56e0\u4e3a\u5b83\u4f1a\u5f15\u53d1\u5f88\u591a\u7684\u7a81\u53d8\uff09\u800c\u662f\u8ba9\u5b83\u81ea\u6211\u4ea7\u751f\u5927\u91cf\u7684\u7ec6\u80de\uff0c\u518d\u5c06\u8fd9\u4e9b\u7f16\u8f91\u7684\u7ec6\u80de\u548c\u4e0d\u7f16\u8f91\u7684\u7ec6\u80de\u540c\u65f6\u8fdb\u884c\u9ad8\u901a\u91cf\u7684\u6d4b\u5e8f\u8fdb\u884c\u6bd4\u8f83\uff0c\u6ca1\u6709\u504f\u5411\u6027\u3002<\/div>\n<div>4\uff09\u6211\u4eec\u5efa\u7acb\u4e86\u4eba\u6e90\u5316\u52a8\u7269\u6a21\u578b\u751f\u4ea7\u5e73\u53f0\uff0c\u6700\u5927\u7684\u74f6\u9888\u5c31\u662f\u5efa\u7acbGMP\u7ea7AAV\u7684\u75c5\u6bd2\u751f\u4ea7\u4e0e\u5b89\u5168\u8bc4\u4ef7\u5e73\u53f0\uff0c\u6211\u4eec\u81ea\u5df1\u5728\u5f00\u53d1\uff0c\u4e5f\u5728\u5bfb\u6c42\u5408\u4f5c\uff0c\u4ece\u57fa\u7840\u79d1\u7814\u9010\u6e10\u8f6c\u5316\u5230\u4e34\u5e8a\u3002\u53bb\u5e74\u5e74\u5e95\u6210\u7acb\u4e86\u6211\u4eec\u6210\u7acb\u8f89\u5927\u751f\u7269\u6cbb\u7597\u516c\u53f8\uff0c\u4e5f\u662f\u805a\u7126\u4e8e\u7f55\u89c1\u75c5\u57fa\u56e0\u836f\u7684\u7814\u53d1\uff0c\u4e5f\u5e0c\u671b\u548c\u5927\u5bb6\u5408\u4f5c\u3002\u516c\u53f8\u4e3b\u8981\u5173\u6ce8\u4e8e\u795e\u7ecf\u7cfb\u7edf\u3001\u773c\u775b\u548c\u8033\u6735\u76f8\u5173\u7684\u75be\u75c5\uff0c\u5c0f\u9f20\u52a8\u7269\u5b9e\u9a8c\u57fa\u672c\u5df2\u7ecf\u5b8c\u6210\u4e86\uff0c\u73b0\u5728\u6b63\u5728\u7b49\u5f85\u4e00\u4e2a\u9002\u5408\u7684GMP\u836f\u7269\uff0c\u6700\u7ec8\u7533\u62a5\u4e34\u5e8a\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u8303\u52c7\uff0c\u5e7f\u5dde\u533b\u79d1\u5927\u5b66\u7814\u7a76\u5458\u00a0<\/div>\n<div>CRISPR\/Cas9\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u5728\u751f\u6b96\u533b\u5b66\u4e2d\u7684\u5e94\u7528<\/div>\n<div>1\uff09CSISPR\/Cas 9\u8fdb\u884c\u5730\u8d2bHBB\u57fa\u56e0\u9ad8\u6548\u4fee\u590d\uff0c\u5728\u4eba\u7c7b3PN\u80da\u80ce\u4e2d\u5b9e\u73b0CCR5\u57fa\u56e0\u7f16\u8f91\u3002<\/div>\n<div>2\uff09\u5375\u7ec6\u80de\u80de\u6d46\u7f6e\u6362\u6280\u672f\u6cbb\u7597\u7ebf\u7c92\u4f53\u75be\u75c5\u3002\u4f46\u5b58\u5728\u5b89\u5168\u9690\u60a3\uff0c\u5305\u62ec\u540e\u7eed\u590d\u5236\u4e2d\u7684\u7a81\u53d8\uff0c\u57fa\u56e0\u7f16\u8f91\u6280\u672fTALEN\u53ef\u4ee5\u6e05\u695aiPS\u7ec6\u80de\u7a81\u53d8\u7ebf\u7c92\u4f53\uff0c\u6e05\u9664\u7a81\u53d8\u91cd\u6784\u732a\u5375\u4e2d\u4eba\u7684\u7a81\u53d8\u7ebf\u7c92\u4f53\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u738b\u73fa \u6770\u6bc5\u751f\u7269\u521b\u59cb\u4eba<\/div>\n<div>\u300a\u65b0\u4e00\u4ee3\u5206\u5b50\u8bca\u65ad\u5b9e\u9a8c\u5ba4\u300b<\/div>\n<div>\u738b\u73fa\u535a\u58eb\u4ece\u65b0\u4e00\u4ee3\u5206\u5b50\u8bca\u65ad\u5b9e\u9a8c\u5ba4total solution\u7684\u7406\u5ff5\u89d2\u5ea6\uff0c\u4ecb\u7ecd\u4e86\u4e24\u5957\u8bbe\u5907\uff1a<\/div>\n<div>1\uff09\u6d41\u6c34\u7ebf\u5206\u5b50\u76d1\u6d4b\u4eeaSMAP\uff0c\u6211\u4eec\u91cd\u6784\u4e86\u6240\u6709\u6838\u9178\u63d0\u53d6\u7684\u6d41\u7a0b\uff0c\u91c7\u7528\u4e86\u6d41\u6c34\u7ebf\u7684\u65b9\u5f0f\u968f\u5230\u968f\u68c0\uff0c\u6bcf\u4e2a\u6837\u672c90\u5206\u949f\u5185\u51fa\u7ed3\u679c\uff0c\u53ef\u4ee5\u8fdb\u884c\u7075\u6d3b\u7684\u7ec4\u5408\u3002\u901a\u91cf\u4e0a\u4e00\u59298\u4e2a\u5c0f\u65f6\u53ef\u4ee5\u68c0\u6d4b400\u4e2a\u6837\u672c\u3002<\/div>\n<div>2\uff09\u5168\u81ea\u52a8\u5efa\u5e93\u4eeaCubics DxTM, \u65e0\u4eba\u503c\u5b88\uff0c\u5168\u6d41\u7a0b2\u5c0f\u65f6\uff0c\u4ece\u6838\u7b97\u63d0\u53d6\u3001\u6587\u5e93\u6784\u5efa\u3001\u6838\u9178\u7eaf\u5316\u548cNGS Ready\u3002\u540c\u65f6\u7ed3\u5408metAI\u667a\u80fd\u8f85\u52a9\u5206\u6790\u7cfb\u7edf\uff08\u5305\u62ec\u75c5\u4f8b\u7cfb\u7edf\u3001\u6587\u732e\u77e5\u8bc6\u3001\u611f\u67d3\u77e5\u8bc6\u56fe\u8c31\u548c\u8bca\u65ad\u6a21\u578b\uff09\u7b49\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAjt29PWdxxh8DhLiaAxBxiaQtSI5WUQ9icu7jEmvnQDThslRCUBnuS7UIfaYltqrXOEVsAsm1ySqoRA.png\" alt=\"RmFicvQBAkgAjt29PWdxxh8DhLiaAxBxiaQtSI5WUQ9icu7jEmvnQDThslRCUBnuS7UIfaYltqrXOEVsAsm1ySqoRA\"\/><\/figure><\/div>\n\n<\/div>\n<div><\/div>\n<div><\/div>\n<div>\u7b2c\u4e8c\u5929\u7684\u5206\u4f1a\u573a\uff0c\u7b2c\u4e09\u671f\u987e\u5927\u592b\u6c99\u9f99\u300a\u751f\u547d\u79d1\u6280\u521b\u65b0\u5982\u4f55\u6709\u6548\u534f\u4f5c\u521b\u9020\u4e34\u5e8a\u4ef7\u503c\u300b\u4e3e\u884c\u3002<\/div>\n<div><\/div>\n<div><\/div>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAjt29PWdxxh8DhLiaAxBxiaQxk7oWAIM4XhBia91aQ0twaJ4DnfiapjAI1L5kMa0iabCku0GOAZc0dNpg.png\" alt=\"RmFicvQBAkgAjt29PWdxxh8DhLiaAxBxiaQxk7oWAIM4XhBia91aQ0twaJ4DnfiapjAI1L5kMa0iabCku0GOAZc0dNpg\"\/><\/figure><\/div>\n\n<p>\u5609\u5bbe\u5408\u5f71<\/p>\n<\/div>\n<div><\/div>\n<div><\/div>\n<div>\u5177\u4f53\u8bf7\u53c2\u89c1\u516c\u4f17\u53f7\u201c\u987e\u5927\u592b\u5de5\u4f5c\u5ba4\u201d<\/div>\n<div><\/div>\n<div><\/div>\n<div>\u00a0\u76f8\u5173\u9605\u8bfb\u00a0\u00a0<\/div>\n<div><\/div>\n<div><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA3NzYyMzAzMA==&amp;mid=2649454207&amp;idx=1&amp;sn=6f243de9f23a801147f91f834497c38e&amp;scene=21#wechat_redirect\" \/>\u987e\u5927\u592b\u6c99\u9f99\u7b2c\u4e09\u671f\u8bb2\u8005PPT\u5206\u4eab\uff5c\u987e\u5927\u592b\uff1a\u63a2\u7d22\u4e0e\u68a6\u60f3<\/a><\/div>\n<div><\/div>\n<div><\/div>\n<div>\u7f16\u8f91\uff1aNicole<\/div>\n<div>\u6821\u5bf9\uff1aDamine<\/div>\n<div>\u5ba1\u6838\uff1aMark\u00a0<\/div>\n<div><\/div>\n<div><\/div>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDJkslCjQ2eianQraykAic9cibUichkIGia8EuLp3BVEkck3PVXluOAXw8KiciaicupVhsldIek3LTFOgChcg.png\" alt=\"RmFicvQBAkgDJkslCjQ2eianQraykAic9cibUichkIGia8EuLp3BVEkck3PVXluOAXw8KiciaicupVhsldIek3LTFOgChcg\"\/><\/figure><\/div>\n\n<\/div>\n<div>\u00a0<\/div>\n<div>\u65b0\u5a92\u4f53\u7f16\u8f91<\/div>\n<div>\u884c\u4e1a\u5206\u6790\u5e08<\/div>\n<div>\u3010\u6b22\u8fce\u52a0\u5165\u57fa\u56e0\u6167\u3011info@genonet.cn<\/div>\n<div><\/div>\n<div><\/div>\n<div>\u3010\u57fa\u56e0\u6167\u8bfb\u8005\u7fa4\u3011<\/div>\n<div>\u9884\u89c1\u5927\u5496\uff0c\u770b\u89c1\u672a\u6765<\/div>\n<div>\u6dfb\u52a0\u52a9\u624b\u5fae\u4fe1\uff0c\u901a\u5173\uff1a\u5907\u6ce8\u5355\u4f4d-\u804c\u4f4d-\u59d3\u540d\u53ca\u8d50\u540d\u7247<\/div>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/RmFicvQBAkgCIniaBVXdZJGhprQkPPCBddQxw0icic5Z3nzQluvyNB7Rpib69K5AfqwTqF0pk2fLHVuroluTUG7Zwicg\/640?wx_fmt=jpeg\" alt=\"640?wx_fmt=jpeg\"\/><\/figure><\/div>\n\n<\/div>\n<div><\/div>\n<div><\/div>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDwDDlibn6LGMERd60A1XgibkVTEVrPEb1EoTK1HnjticKMtrzWS4eyuZgibs4H2ErBL6cp0GRTKvEAkg.jpeg\" alt=\"RmFicvQBAkgDwDDlibn6LGMERd60A1XgibkVTEVrPEb1EoTK1HnjticKMtrzWS4eyuZgibs4H2ErBL6cp0GRTKvEAkg\"\/><\/figure><\/div>","protected":false},"excerpt":{"rendered":"<p>\u4f1a\u8bae\u7b14\u8bb0<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[996],"tags":[1472],"class_list":["post-9285","post","type-post","status-publish","format-standard","hentry","category-news","tag-ngs"],"_links":{"self":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/9285","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/comments?post=9285"}],"version-history":[{"count":3,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/9285\/revisions"}],"predecessor-version":[{"id":13996,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/9285\/revisions\/13996"}],"wp:attachment":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/media?parent=9285"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/categories?post=9285"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/tags?post=9285"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}