{"id":9269,"date":"2019-05-29T23:55:20","date_gmt":"2019-05-29T15:55:20","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&#038;mid=100010345&#038;idx=1&#038;sn=59b92b55e42e8321d6caa1b8e2bbe45c&#038;chksm=6b715bde5c06d2c8b744e9ccdc089f92884fc18d88dbbbdcbf3816330eacdf24f9ce4a4b635b#rd"},"modified":"2026-04-08T10:23:07","modified_gmt":"2026-04-08T02:23:07","slug":"984949-2","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2019\/05\/29\/984949-2\/","title":{"rendered":"2018\u5e74\u79d1\u7814\u4ea7\u4e1a\u5316\u5341\u4f73\u6848\u4f8b\uff08\u4e0a\uff09 | Nature Biotechnology"},"content":{"rendered":"<p><!-- wechat_content_hash: b1111996beb32cf5 --><\/p>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCuC54K47siaoibvbClYbpoQdmoEA7Yo9T0l4l5c9wsK8DWv13zXvBYojNDUX4HpbxOEe8enSicCuVVg.gif\" alt=\"RmFicvQBAkgCuC54K47siaoibvbClYbpoQdmoEA7Yo9T0l4l5c9wsK8DWv13zXvBYojNDUX4HpbxOEe8enSicCuVVg\"\/><\/figure><\/div>\n\n<\/div>\n<div>\u751f\u547d\u63a2\u54e8<\/div>\n<div>\u751f\u547d\u79d1\u6280\u524d\u6cbf\u8d44\u8baf<\/div>\n<div><\/div>\n<div>\u5173\u952e\u8bcd\/\u514d\u75ab\u6cbb\u7597 \u57fa\u56e0\u7f16\u8f91 \u57fa\u56e0\u6cbb\u7597<\/div>\n<div><\/div>\n<div>\u5f53\u5730\u65f6\u95f42019\u5e745\u670827\u65e5\uff0c\u300aNature Biotechnology\u300b\u516c\u5e032018\u5e74\u79d1\u7814\u4ea7\u4e1a\u5316\u7684\u4f18\u79c0\u6210\u679c\uff0c\u5305\u62ec\u57fa\u56e0\u6cbb\u7597\u3001\u8fc7\u7ee7\u6027\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\u3001\u57fa\u56e0\u7f16\u8f91\u3001\u57fa\u4e8eRNA\u4fee\u9970\u7684\u548c\u672a\u6298\u53e0\u86cb\u767d\u53cd\u5e94\u7684\u836f\u7269\u7b49\u5341\u5927\u6848\u4f8b\u3002\u57fa\u56e0\u6167\u6458\u8bd1\u5982\u4e0b\u4f9b\u6218\u7565\u53ca\u6295\u878d\u8d44\u53c2\u8003\uff0c\u4e0d\u5c3d\u4e4b\u5904\u8bf7\u53c2\u8003\u539f\u6587\u3002\u56de\u590d\u201cNBT\u201d\u53ef\u83b7\u5f97\u82f1\u6587\u5168\u6587PDF\u3002<\/div>\n<div>\u5728\u8fc7\u53bb\u7684\u4e00\u5e74\u4e2d\uff0c\u751f\u7269\u6280\u672f\u9886\u57df\u7684\u65e9\u671f\u6295\u8d44\u4ee4\u4eba\u77a9\u76ee\uff0c\u5168\u7403\u751f\u7269\u6280\u672f\u79c1\u4eba\u4f01\u4e1a\u5171\u878d\u8d44240\u4ebf\u7f8e\u5143\uff0c\u662f2017\u5e74\u4e00\u5e74\u7684\u4e24\u500d\uff0c\u4e5f\u6253\u7834\u4e86\u5386\u53f2\u8bb0\u5f55\u3002<\/div>\n<div>\u4e0e\u5f80\u5e74\u4e00\u6837\uff0c\u300aNature Biotechnology\u300b\u6311\u9009\u4ece\u5b66\u672f\u673a\u6784\u4e2d\u5b75\u5316\uff08spun out\uff09\u51fa\u6765\u7684\u7814\u53d1\u578b\u521d\u521b\u516c\u53f8\uff0c\u6839\u636e\u4ed6\u4eec\u7684A\u8f6e\u878d\u8d44\u91d1\u989d\u8fdb\u884c\u6392\u540d\uff0c\u7ed3\u5408\u516c\u5f00\u7684\u7814\u7a76\u4fe1\u606f\uff08\u6709\u4e9b\u516c\u53f8\u88ab\u9009\u4e2d\u4f46\u62d2\u7edd\u516c\u5f00\uff09\uff0c\u5217\u8868\u5982\u4e0b\u3002\u8fd9\u662f\u300aNature Biotechnology\u300b\u8ba4\u4e3a2018\u5e74\u79d1\u7814\u4ea7\u4e1a\u5316\u7684\u6700\u4f73\uff08\u4e5f\u662f\u8d44\u91d1\u6700\u96c4\u539a\u7684\uff09\u6848\u4f8b\u3002<\/div>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDkcYfYtbRSHcS6KuFA4QCdDCYzGCvkAGlNrvRw0vuKj8Bc3N62ITnNCTW46XcWM35M8IQCOL72dQ.png\" alt=\"RmFicvQBAkgDkcYfYtbRSHcS6KuFA4QCdDCYzGCvkAGlNrvRw0vuKj8Bc3N62ITnNCTW46XcWM35M8IQCOL72dQ\"\/><\/figure><\/div>\n\n<\/div>\n<div style=\"text-align: center;\">\u56fe\uff1a2018\u5e74\u79d1\u7814\u4ea7\u4e1a\u5316\u5341\u4f73\u6848\u4f8b\uff0c\u6765\u81ea Nature BiotechnologyVolume 37 Issue 5, May 2019<\/div>\n<div>\u4ee5\u4e0b\u662f\u6240\u9009\u4f01\u4e1a\u53ca\u5176\u4ea7\u54c1\u80cc\u540e\u7684\u6545\u4e8b\u7684\u4e0a\u96c6\uff0c\u5206\u522b\u662f\uff1a<\/div>\n<div>1. Akouos\uff1a\u542c\u529b\u969c\u788d\u7684\u57fa\u56e0\u6cbb\u7597<\/div>\n<div>2.\u00a0Senti Biosciences\uff1a\u8fc7\u7ee7\u6027\u514d\u75ab\u7ec6\u80de\u6cbb\u7597<\/div>\n<div>3.\u00a0Carisma Therapeutics\uff1a\u5de8\u566c\u7ec6\u80de\u514d\u75ab\u7597\u6cd5<\/div>\n<div>4. Cabaletta Bio\uff1a\u5de8\u566c\u7ec6\u80de\u514d\u75ab\u7597\u6cd5<\/div>\n<div>5. Quentis therapeutics: \u672a\u6298\u53e0\u86cb\u767d\u53cd\u5e94\u836f\u7269<\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/mmbiz.qlogo.cn\/mmbiz_jpg\/RmFicvQBAkgDkcYfYtbRSHcS6KuFA4QCdZeo5ZvaWZBBbhOEsoS5qyYsYA7wM6c4r0nsR4UiakcqjibSlACmZ8Dnw\/0?wx_fmt=jpeg\" alt=\"0?wx_fmt=jpeg\"\/><\/figure><\/div>\n\n<div>1. Akouos\uff1a\u542c\u529b\u969c\u788d\u7684\u57fa\u56e0\u6cbb\u7597<\/div>\n<div>Emmanuel Simons\u6700\u65e9\u57282008\u5e74\u60f3\u6210\u7acb\u4e00\u5bb6\u542c\u529b\u969c\u788d\u6cbb\u7597\u516c\u53f8\uff0c\u5f53\u65f6\u611f\u89c9\u201c\u65f6\u673a\u4e0d\u5bf9\u201d\u30022016\u5e74\u8054\u5408\u6765\u81ea\u9a6c\u8428\u8bf8\u585e\u5dde\u773c\u8033\u533b\u9662\u548c\u7231\u8377\u534e\u5927\u5b66\u7684\u5408\u4f19\u4eba\u4e00\u8d77\u521b\u7acb\u4e86Akouos\u3002\u76ee\u524d\u516c\u53f8\u6b63\u5f00\u53d1\u7528\u4e8e\u611f\u89c9\u795e\u7ecf\u6027\u542c\u529b\u635f\u5931\u7684\u57fa\u56e0\u7597\u6cd5\u3002\u7531\u5185\u8033\u611f\u89c9\u7ec6\u80de\/\u795e\u7ecf\u7ea4\u7ef4\u7684\u635f\u4f24\u6216\u529f\u80fd\u969c\u788d\u5f15\u8d77\u7684\u542c\u529b\u635f\u5931\u662f\u65b0\u751f\u513f\u8033\u804b\u7684\u6700\u5e38\u89c1\u539f\u56e0\u4e4b\u4e00\uff0c\u572865\u5c81\u4ee5\u4e0a\u7684\u4eba\u4e2d\u4e5f\u65e5\u76ca\u9ad8\u53d1\uff0c\u51e0\u4e4e\u5f71\u54cd\u5230\u8fd9\u4e2a\u5e74\u9f84\u6bb5\u4eba\u7fa4\u7684\u56db\u5206\u4e4b\u4e00\u3002<\/div>\n<div>\u8033\u6735\u4f5c\u4e3a\u4e00\u79cd\u8106\u5f31\u4e14\u9ad8\u5ea6\u590d\u6742\u7684\u5668\u5b98\uff0c\u9664\u4e86\u5206\u5b50\u7ed3\u6784\u590d\u6742\u5916\uff0c\u5185\u8154\u6bd4\u8f83\u5c0f\u96be\u4ee5\u8fdb\u5165\u4e14\u5bf9\u5916\u90e8\u65bd\u7528\u7684\u836f\u7269\u56e0\u4e3a\u538b\u529b\u548c\u4f53\u79ef\u654f\u611f\u3002 Akouos\u6b63\u5728\u7814\u7a76\u5305\u62ec\u5185\u8033\u836f\u4ee3\u52a8\u529b\u5b66\uff0c\u836f\u7269\u8f93\u9001\u3001\u57fa\u56e0\u6cbb\u7597\u8f7d\u4f53\u4ee5\u53ca\u4e0e\u542c\u529b\u969c\u788d\u6709\u5173\u7684\u6f5c\u5728\u57fa\u56e0\u9776\u70b9\uff08\u57fa\u4e8e\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff09\u3002FDA\u76ee\u524d\u6ca1\u6709\u6279\u51c6\u7531\u5185\u8033\u6216\u542c\u529b\u795e\u7ecf\u7684\u75c5\u53d8\u5f15\u8d77\u7684\u75be\u75c5\u6cbb\u7597\u65b9\u5f0f\u3002\u4f462017\u5e74FDA\u6279\u51c6\u4e86Spark Therapeutics\u516c\u53f8\uff082019\u5e742\u6708\u88abRoche\u4ee543\u4ebf\u7f8e\u5143\u6536\u8d2d\uff09\u65b0\u578b\u57fa\u56e0\u7597\u6cd5Luxturna\u5e26\u6765\u4e86\u5e0c\u671b\uff08\u56e0\u4e3a\u773c\u775b\u548c\u8033\u6735\u7684\u90e8\u5206\u5171\u540c\u7279\u5f81\uff09\u3002\u968f\u7740Luxturna\u7684\u83b7\u6279\uff0cAAV \u6b63\u5728\u6210\u4e3a\u57fa\u56e0\u6cbb\u7597\u7684\u4e3b\u529b\u75c5\u6bd2\u5de5\u5177\u3002<\/div>\n<div>Simons\u63d0\u5230\uff0c\u4eba\u5de5\u8033\u8717\u690d\u5165\u7684\u6210\u529f\u4e0e\u5426\u662f\u5bf9\u76ee\u6807\u9009\u62e9\u548c\u8bd5\u9a8c\u8bbe\u8ba1\u7684\u91cd\u8981\u5f71\u54cd\u56e0\u7d20\u3002\u8be5\u516c\u53f8\u4e13\u6ce8\u4e8e\u4eba\u5de5\u8033\u8717\u690d\u5165\u5f71\u54cd\u751a\u5fae\u6216\u51e0\u4e4e\u65e0\u6548\u7684\u542c\u529b\u969c\u788d\u4eba\u7fa4\u3002\u8bfa\u534e\uff08Novartis\uff09\u7b49\u8de8\u56fd\u516c\u53f8\u662fAkouos\u5728\u8be5\u9886\u57df\u7684\u7ade\u4e89\u5bf9\u624b\uff0c\u8bfa\u534e\u516c\u53f8\u7684\u91cd\u7ec4\u817a\u75c5\u6bd2\u57fa\u56e0\u6cbb\u7597\uff08CGF166\uff09\u4eba\u4e25\u91cd\u542c\u529b\u635f\u5931\u6b63\u8fdb\u884c\u52301\/2\u9636\u6bb5\u3002\u5176\u4ed6\u751f\u7269\u6280\u672f\u521d\u521b\u516c\u53f8\uff0c\u4f8b\u5982Sound Pharmaceuticals\u548cFrequency Therapeutics\uff0c\u6b63\u5728\u901a\u8fc7\u5c0f\u5206\u5b50\u548c\u518d\u751f\u533b\u5b66\u800c\u4e0d\u662f\u57fa\u56e0\u7597\u6cd5\u6765\u653b\u514b\u542c\u529b\u969c\u788d\u6cbb\u7597\u3002\u8fc7\u53bb\u768418\u4e2a\u6708\uff0cAkouos\u5df2\u4ece3\u540d\u5458\u5de5\u53d1\u5c55\u523025\u540d\u5458\u5de5\uff0c\u5e76\u51c6\u5907\u642c\u5165\u53ef\u5bb9\u7eb3\u6570\u767e\u4eba\u7684\u65b0\u529e\u516c\u573a\u6240\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDkcYfYtbRSHcS6KuFA4QCdYiaY7M9rib8JnmriaIno04tRMyYA1BcNH4MgOfVbknzyHZLS9NEnennUQ.png\" alt=\"RmFicvQBAkgDkcYfYtbRSHcS6KuFA4QCdYiaY7M9rib8JnmriaIno04tRMyYA1BcNH4MgOfVbknzyHZLS9NEnennUQ\"\/><\/figure><\/div>\n\n<div>2.\u00a0Senti Biosciences\uff1a\u8fc7\u7ee7\u6027\u514d\u75ab\u7ec6\u80de\u6cbb\u7597<\/div>\n<div>2017\u5e74FDA\u6279\u51c6\u4e86\u4e24\u79cd\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CAR\uff09-T\u7597\u6cd5\uff1a\u6765\u81ea\u00a0Novartis\u7684Kymriah\u548c\u6765\u81eaGilead Sciences\u7684Yescarta\uff0c\u660e\u786e\u4e86\u8fc7\u7ee7\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u5728CD19+\u00a0B\u7ec6\u80de\u6076\u6027\u80bf\u7624\u60a3\u8005\u4e2d\u6709\u663e\u8457\u7597\u6548 \u3002\u4f46\u5230\u76ee\u524d\u4e3a\u6b62\uff0c \u8be5\u65b9\u6cd5\u5c1a\u672a\u8f6c\u5316\u5230\u5176\u4ed6\u6cbb\u7597\u65b9\u6848\uff0c\u56e0\u800c\u8bb8\u591a\u516c\u53f8\u81f4\u529b\u4e8e\u6269\u5927\u8fc7\u7ee7\u7ec6\u80de\u7597\u6cd5\u3002<\/div>\n<div>Senti Biosciences\u6b63\u662f\u8fd9\u4e9b\u516c\u53f8\u4e4b\u4e00\uff0c\u901a\u8fc7\u4e3a\u4e0d\u540c\u7684\u514d\u75ab\u7ec6\u80de\u7a0b\u5e8f\u5316\u65b0\u529f\u80fd\u4ee5\u66f4\u597d\u5730\u63a7\u5236\u5176\u5b89\u5168\u6027\u3001\u6bd2\u6027\u3001\u9776\u5411\u6027\u548c\u529f\u6548\u3002Senti\u56e2\u961f\u7684\u76ee\u6807\u662f\u901a\u8fc7\u6574\u5408\u201c\u667a\u80fd\u201d\u7ec4\u4ef6\u2014\u2014\u4f8b\u5982\u5408\u6210\u57fa\u56e0\u7535\u8def\u548c\u5206\u5b50\u5f00\u5173\u2014\u2014\u5c06\u53ef\u7f16\u7a0b\u903b\u8f91\u5728\u4e00\u5b9a\u7a0b\u5ea6\u7684\u5f15\u5165\u7ec6\u80de\u6cbb\u7597\u7cfb\u7edf \u3002 \u201c\u6211\u4eec\u60f3\u8981\u521b\u9020\u65b0\u578b\u836f\u7269\uff0c\u53ef\u4ee5\u8fdb\u884c\u7a0b\u5f0f\u5316\u548c\u53d7\u63a7\u5236\u7684\u836f\u7269\uff0c\u201c\u6765\u81eaMIT\u7684\u9996\u5e2d\u6267\u884c\u5b98Tim Lu\u8bf4\u9053\u3002\u4ed6\u4eec\u5728\u7275\u5934\u5375\u5de2\u764c\u76f8\u5173\u7684\u7ec6\u80de\u7597\u6cd5\u3002<\/div>\n<div>\u6765\u81ea\u6ce2\u58eb\u987f\u5927\u5b66\u7684\u8054\u5408\u521b\u59cb\u4ebaWilson Wong\u7b49\u4eba\u4e3aSenti\u7684CAR-T\u7597\u6cd5\u63d0\u4f9b\u4e86\u6280\u672f\u8bba\u636e\u3002CAR\u7684SUPRA\u67b6\u6784\u80fd\u591f\u8f7b\u677e\u5207\u6362\u6297\u539f\u9776\u6807\u800c\u65e0\u9700\u91cd\u65b0\u8bbe\u8ba1\u60a3\u8005\u7684T\u7ec6\u80de\uff0c\u80fd\u591f\u5c06T\u7ec6\u80de\u6d3b\u5316\u81f3\u6240\u9700\u6c34\u5e73\uff0c\u800c\u4e14\u5176\u6297\u539f\u8bc6\u522b\u7a0b\u5e8f\u6bd4\u76ee\u524d\u65b9\u6cd5\u66f4\u590d\u6742\u548c\u6709\u9009\u62e9\u6027\u3002 \u5176\u8bbe\u8ba1\u7684\u5173\u952e\u662f\u4f7f\u7528\u6210\u5bf9\u7684\u4eae\u6c28\u9178\u62c9\u94fe &#8211; \u4e92\u8865\u86cb\u767d\u8bc6\u522b\u7ed3\u6784\u57df\u3002\u79f0\u4e3a&#8217;zipFv&#8217;\u7684\u6297\u539f\u8bc6\u522b\u5143\u4ef6\u7531\u7ecf\u5178CAR-T\u6784\u5efa\u4f53\u4e2d\u4f7f\u7528\u7684\u5355\u94fe\u53ef\u53d8\u7247\u6bb5\uff08scFv\uff09\u7ec4\u6210\uff0c\u4e0e\u4e00\u4e2a\u4eae\u6c28\u9178\u62c9\u94fe\u878d\u5408\u3002\u5c06T\u7ec6\u80de\u5de5\u7a0b\u5316\u4ee5\u8868\u8fbe \u201czipCAR\u201d\u3002Senti\u2019s Collins\u8bf4\uff1a\u201c\u76ee\u524d\u7684\u65b9\u6848\u5df2\u5728\u7ec6\u80de\u57f9\u517b\u548c\u52a8\u7269\u6a21\u578b\u4e2d\u5f97\u5230\u5f88\u597d\u7684\u6d4b\u8bd5\uff0c\u4e0b\u4e00\u6b65\u662f\u83b7\u5f97FDA\u7814\u7a76\u65b0\u836f\u6279\u51c6\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u201d\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDkcYfYtbRSHcS6KuFA4QCdvTod88Yic9wlQLLvYB3tTkwxW58gEUJ8JVVPAhOicD15eaPsgZOsRdBQ.png\" alt=\"RmFicvQBAkgDkcYfYtbRSHcS6KuFA4QCdvTod88Yic9wlQLLvYB3tTkwxW58gEUJ8JVVPAhOicD15eaPsgZOsRdBQ\"\/><\/figure><\/div>\n\n<div>3.\u00a0Carisma Therapeutics\uff1a\u5de8\u566c\u7ec6\u80de\u514d\u75ab\u7597\u6cd5<\/div>\n<div>\u5728\u7f8e\u56fd\u4e1c\u6d77\u5cb8\uff0c\u9488\u5bf9CAR\u7597\u6cd5\u7684\u5347\u7ea7\uff0cCarisma Therapeutics\u5e03\u5c40\u7684\u4e0d\u662fT\u7ec6\u80de\uff0c\u800c\u662f\u5de8\u566c\u7ec6\u80de\u3002\u8be5\u65b9\u6cd5\u59cb\u4e8e2013\u5e74\uff0c\u5f53\u65f6Michael Klichinsky\u5728\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u5728CAR-T\u6743\u5a01Carl June\u548c\u540e\u8d77\u4e4b\u79c0Saar Gill\u7684\u8054\u5408\u6307\u5bfc\u4e0b\u5f00\u59cb\u653b\u8bfb\u535a\u58eb\u5b66\u4f4d\u3002\u4e09\u5e74\u540e\uff0cKlichinsky\u548c\u4ed6\u7684\u5bfc\u5e08Gill\u4e0e\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u521b\u65b0\u4e2d\u5fc3\u5408\u4f5c\uff0c\u4e8e2018\u5e74\u6210\u7acbCARMA Therapeutics\u2014\u2014\u540e\u56e0\u5546\u6807\u51b2\u7a81\u66f4\u540d\u4e3aCarisma Therapeutics\u3002\u81ea2018\u5e742\u6708\u4ee5\u6765\uff0cCarisma\u4ece3\u540d\u589e\u52a0\u523015\u540d\u5458\u5de5\u3002<\/div>\n<div>Carisma\u57fa\u4e8e\u7684\u7406\u8bba\u662f\uff0c\u5de8\u566c\u7ec6\u80de\u57fa\u4e8e\u80bf\u7624\u5206\u6ccc\u7684\u5316\u5b66\u5f15\u8bf1\u7269\u81ea\u7136\u5bfc\u5411\uff08traffic\uff09\u80bf\u7624\uff1b\u4f46\u540c\u65f6\u4e5f\u5b58\u5728\u95ee\u9898\uff0c\u5373\u5de8\u566c\u7ec6\u80de\u4e5f\u80fd\u523a\u6fc0\u80bf\u7624\u751f\u957f\u548c\u6291\u5236T\u7ec6\u80de\u6d3b\u6027\u3002\uff08\u597d\u5728\uff09\u8be5\u6982\u5ff5\u5728Klichinsky\u65e9\u671f\u7528THP-1\u5de8\u566c\u7ec6\u80de\u7cfb\u8fdb\u884c\u7684\u5b9e\u9a8c\u4e2d\u5f97\u5230\u4e86\u652f\u6301\u3002<\/div>\n<div>Klichinsky\u8bbe\u8ba1\u4e86\u57fa\u4e8e\u6162\u75c5\u6bd2\u8f7d\u4f53\u7684\u5de8\u566c\u7ec6\u80de\u7cfb\u4ee5\u8868\u8fbe\u9488\u5bf9\u5404\u79cd\u7ec6\u80de\u8868\u9762\u6297\u539f\u7684\u5404\u79cdCAR\uff0c\u4f8b\u5982\u95f4\u76ae\u7d20\u6216CD19\u3002\u4ed6\u8bf4\uff1a\u201c\u6211\u4eec\u53ef\u4ee5\u670d\u7528\u5de8\u566c\u7ec6\u80de\uff0c\u653e\u5165\u4e00\u4e2a\u57fa\u56e0\u5e76\u544a\u8bc9\u5de8\u566c\u7ec6\u80de\u5403\u4ec0\u4e48\u3002\u201d\u4f8b\u5982\uff0c\u5982\u679cCAR\u9488\u5bf9CD19\uff0c\u5219\u5de5\u7a0b\u5316\u7684\u5de8\u566c\u7ec6\u80de\u53ef\u4ee5\u5403\u6389\u5e76\u6740\u6b7bCD19 +\u80bf\u7624\u7ec6\u80de\u3002\u8fd9\u662f\u9996\u6b21\u8bc1\u660e\u5355\u4e00\u57fa\u56e0\u53ef\u4ee5\u91cd\u65b0\u8fdb\u884c\u541e\u566c\u4f5c\u7528\u3002 \u201c\u65e0\u8bba\u6211\u4eec\u6307\u5bfcCAR\u5bf9\u6297\u4ec0\u4e48\uff0c\u5de8\u566c\u7ec6\u80de\u90fd\u53ef\u4ee5\u8ffd\u8e2a\u8fd9\u79cd\u7269\u8d28\u5e76\u964d\u89e3\u5b83\u201d\u3002\u9664\u4e86CD19\uff0c\u4ed6\u4eec\u8fd8\u5728\u95f4\u76ae\u7d20\u548cHER-2\u4e0a\u8fdb\u884c\u4e86\u6d4b\u8bd5\u3002\u6b64\u5916\uff0c\u9776\u5411\u541e\u566c\u4f5c\u7528\u4e0d\u9700\u8981\u989d\u5916\u7684\u6297\u4f53\u3001\u8865\u4f53\u86cb\u767d\u6216\u50cfCD47\u4e00\u7c7b\u7684\u201c\u4e0d\u8981\u5403\u6211\u201d\u7684\u6291\u5236\u4fe1\u53f7\u3002<\/div>\n<div>\u4e0b\u4e00\u4e2a\u969c\u788d\u662f\u4f7f\u5176\u4e0e\u4eba\u539f\u4ee3\u5355\u6838\u7ec6\u80de\u4e00\u8d77\u53d1\u6325\u4f5c\u7528\uff0c\u5373\u5206\u5316\u4e3a\u5de8\u566c\u7ec6\u80de\u7684\u767d\u7ec6\u80de\u3002\u6211\u4eec\u77e5\u9053\u9057\u4f20\u64cd\u7eb5\u5355\u6838\u7ec6\u80de\u975e\u5e38\u56f0\u96be\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u514d\u75ab\u7ec6\u80de\u5f88\u96be\u5728\u539f\u4ee3\u7ec6\u80de\u57f9\u517b\u7269\u4e2d\u611f\u67d3\u800c\u4e14\u751f\u957f\u4e0d\u7406\u60f3\u3002 Klichinsky\u82b1\u4e86\u4e00\u5e74\u591a\u7684\u65f6\u95f4\uff0c\u6d4b\u8bd5\u81f3\u5c11\u5341\u79cd\u4e0d\u540c\u7684\u57fa\u56e0\u4f20\u9012\u65b9\u6cd5\u627e\u5230\u4e00\u4e2a\u53ef\u884c\u7684\uff1a\u4e00\u79cd\u590d\u5236\u7f3a\u9677\u7684\u5d4c\u5408\u817a\u75c5\u6bd2\u8f7d\u4f53Ad5f35\u3002Klichinsky\u5b9e\u73b0\u4e86\u4ece10\u4e2a\u4eba\u4f9b\u4f53\u5206\u522b\u7eaf\u5316\u7684\u5355\u6838\u7ec6\u80de75\uff05\u6709\u6548\u9012\u9001\u3002\u00a0<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDkcYfYtbRSHcS6KuFA4QCdficgiaeeByPXERGNFfSyUZcyDf2D3z51sECuw5xmK5kAfMwmibHVsCVYg.png\" alt=\"RmFicvQBAkgDkcYfYtbRSHcS6KuFA4QCdficgiaeeByPXERGNFfSyUZcyDf2D3z51sECuw5xmK5kAfMwmibHVsCVYg\"\/><\/figure><\/div>\n\n<div><\/div>\n<div>4.\u00a0Cabaletta Bio\uff1a\u5de8\u566c\u7ec6\u80de\u514d\u75ab\u7597\u6cd5<\/div>\n<div>\u79bbCarisma\u51e0\u82f1\u91cc\u7684\u5730\u65b9\uff0c\u662f\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66CAR-T\u7814\u7a76\u5b75\u5316\u7684\u53e6\u4e00\u5bb6\u516c\u53f8Cabaletta Bio\u3002\u9996\u5e2d\u6267\u884c\u5b98\u517c\u8463\u4e8b\u957fSteven Nichtberger\u56de\u5fc6\u521b\u7acb\u516c\u53f8\u65f6\u8c08\u5230\uff0c\u5927\u591a\u6570\u4eba\u4ecd\u5728\u63a2\u7d22CAR-T\u6280\u672f\u5982\u4f55\u89e3\u51b3\u764c\u75c7\u610f\u5916\u7684\u5176\u4ed6\u75be\u75c5\u95ee\u9898\uff0c\u6bd4\u5982Michael Milone and Aimee Payne\u63d0\u51fa\u7684B\u7ec6\u80de\u4ecb\u5bfc\u7684\u75be\u75c5\u3002\u4e3a\u4e86\u63a2\u7d22\u8fd9\u4e00\u70b9\uff0c\u4ed6\u4eec\u5171\u540c\u521b\u7acb\u4e86Cabaletta\uff0c\u65e8\u5728\u5c06CAR-T\u7597\u6cd5\u4ece\u764c\u75c7\u8f6c\u5411\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u3002<\/div>\n<div><\/div>\n<div>Nichtberger\u662f\u4e00\u4f4d\u8fde\u7eed\u7684\u751f\u7269\u6280\u672f\u521b\u4e1a\u8005\uff0c\u4ed6\u5728\u6c83\u987f\u5546\u5b66\u9662\u8bb2\u6388\u533b\u7597\u5065\u5eb7\u516c\u53f8\u7ec4\u6210\u7acb\u3001\u878d\u8d44\u548c\u9886\u5bfc\u529b\u76f8\u5173\u7684\u9ad8\u7aef\u8bfe\u7a0b\u3002\u5728\u8bfe\u5802\u9879\u76ee\u8ba8\u8bba\u4e2d\uff0c\u53d1\u73b0\u4e86\u65b0\u751f\u7684\u751f\u7269\u6280\u672f\uff0c\u4e8e\u662f\u5728\u8bfe\u7a0b\u7ed3\u675f\u51e0\u4e2a\u6708\u540e\u6210\u4e3a\u8be5\u65b0\u5174\u516c\u53f8\u7684\u8054\u5408\u521b\u59cb\u4eba\u548c\u9996\u5e2d\u6267\u884c\u5b98\u3002\u8be5\u516c\u53f8\u5b8c\u6210\u4e86\u4e24\u8f6e\u5171\u8ba18800\u4e07\u7f8e\u5143\u7684\u878d\u8d44\uff0c\u7528\u4e8e\u5f00\u53d1\u201c\u5d4c\u5408\u81ea\u4f53\u6297\u4f53T\u7ec6\u80de\u201d\u7597\u6cd5\uff0c\u7b80\u79f0\u201cCAAR-T\u201d\u2014\u2014\u91c7\u75284-1BB\uff08CD137\uff09\u5171\u523a\u6fc0\u7ed3\u6784\u57df\u548cCD3-\u03b6\u4fe1\u53f7\u4f20\u5bfc\u7ed3\u6784\u57df\u9a71\u52a8T\u7ec6\u80de\u7684\u6fc0\u6d3b\u548c\u7ec6\u80de\u6bd2\u6027\u3002Cabaletta\u56e2\u961f\u5e0c\u671b\uff0c\u76f8\u6bd4\u76ee\u524d\u514d\u75ab\u6291\u5236\u7c7b\u56fa\u9187\u548cCD20\u5b9a\u5411\u6297\u4f53\u5229\u59a5\u6614\u5355\u6297\u5728\u5185\u6807\u51c6\u7597\u6cd5\uff0cCAAR-T\u7597\u6cd5\u80fd\u591f\u6709\u66f4\u6301\u7eed\u7684\u7f13\u89e3\u6548\u679c\u3002<\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/mmbiz.qlogo.cn\/mmbiz_jpg\/RmFicvQBAkgDkcYfYtbRSHcS6KuFA4QCdDbRA6JHmwam2XURD6rcHrPZ3DX7W2k8ibaTI0p2FDy2yOxQPX2uyO3w\/0?wx_fmt=jpeg\" alt=\"0?wx_fmt=jpeg\"\/><\/figure><\/div>\n\n<\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<div>5. Quentis therapeutics:\u00a0\u672a\u6298\u53e0\u86cb\u767d\u53cd\u5e94\u836f\u7269<\/div>\n<div><\/div>\n<div>Quentis therapeutics\u770b\u8d77\u6765\u4e0d\u50cf\u662f\u4e00\u5bb6\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u516c\u53f8\u3002\u5b83\u7684\u76ee\u6807\u662f\u672a\u6298\u53e0\u86cb\u767d\u53cd\u5e94\uff08UPR\uff09\u2014\u2014\u5bf9\u5185\u8d28\u7f51\uff08ER\uff09\u7684\u5e94\u6fc0\u9002\u5e94\u6027\u53cd\u5e94\u3002<\/div>\n<div><\/div>\n<div>\u5185\u8d28\u7f51\u662f\u4e00\u79cd\u7ec6\u80de\u5668\uff0c\u5176\u4e2d\u6700\u7ec8\u8981\u5206\u6ccc\u7684\u86cb\u767d\u8d28\u88ab\u6298\u53e0\u548c\u52a0\u5de5\u3002\u5f53\u5185\u8d28\u7f51\u4e2d\u672a\u6298\u53e0\u7684\u86cb\u767d\u8d28\u8fc7\u8f7d\u65f6\uff0cUPR\u5f00\u59cb\u8d77\u4f5c\u7528\uff0c\u51cf\u7f13\u86cb\u767d\u8d28\u5408\u6210\u5e76\u4fc3\u8fdb\u6298\u53e0\u80fd\u529b\u3002\u67d0\u4e9b\u764c\u75c7\u4f9d\u8d56\u4e8eUPR\u7684\u5b58\u6d3b\uff0c\u800c\u4e14\u79d1\u5b66\u5bb6\u5df2\u7ecf\u4e86\u89e3\u5e72\u6270\u764c\u7ec6\u80de\u4e2dUPR\u7684\u836f\u7269\u5177\u6709\u6cbb\u7597\u6f5c\u529b\u3002\u90a3\u4e48\u8fd9\u4e0e\u514d\u75ab\u7cfb\u7edf\u6709\u4ec0\u4e48\u5173\u7cfb\u5462\uff1f<\/div>\n<div><\/div>\n<div>Quentis\u8054\u5408\u521b\u59cb\u4ebaLaurie Glimcher\uff0c\u73b0\u4efb\u6ce2\u58eb\u987fDana-Farber\u764c\u75c7\u7814\u7a76\u6240\u7684\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98\uff0c\u4e8e2015\u5e74\u5728\u7ebd\u7ea6\u5a01\u5c14\u5eb7\u5948\u5c14\u533b\u5b66\u9662\u62c5\u4efb\u9662\u957f\u65f6\u56e0\u4e3a\u8ba4\u8bc6\u4e00\u4e2a\u4eba\u57cb\u4e0b\u4e86\u4f0f\u7b14\u3002<\/div>\n<div><\/div>\n<div>\u65e9\u57281988\u5e74\uff0c\u4f5c\u4e3a\u4e00\u540d\u5e74\u8f7b\u7684\u54c8\u4f5b\u5927\u5b66\u514d\u75ab\u5b66\u5bb6\uff0cGlimcher\u514b\u9686\u4e86\u8f6c\u5f55\u56e0\u5b50XBP111\uff08\u5b83\u6fc0\u6d3b\u4e86UPR\u7684\u4e09\u4e2a\u81c2\u4e4b\u4e00\uff09\uff0c\u63a5\u4e0b\u6765\u4e8c\u5341\u5e74\u4e2d\u81f4\u529b\u4e8e\u6b64\u3002 2012\u5e74\uff0cGlimcher\u8058\u8bf7\u4e86\u535a\u58eb\u540e\u7814\u7a76\u5458Juan Cubillos-Ruiz\u6765\u7814\u7a76\u5375\u5de2\u764c\u4e2d\u7684\u514d\u75ab\u6291\u5236\u6027\u6811\u7a81\u72b6\u7ec6\u80de\uff0c\u5e76\u5f00\u59cb\u7814\u7a76XBP1\u548cUPR\u5728\u8fd9\u4e9b\u6709\u95ee\u9898\u7684\u7ec6\u80de\u4e2d\u7684\u53ef\u80fd\u4f5c\u7528\u3002<\/div>\n<div><\/div>\n<div>\u57282018\u5e74\uff0c\u4ed6\u548cGlimcher\u5728Nature\u4e2d\u53d1\u5e03\u6210\u679c\uff0c\u60ca\u4eba\u5730\u53d1\u73b0\u5728T\u7ec6\u80de\u4e2d\u63a7\u5236ER\u5e94\u6fc0\u53cd\u5e94\u9700\u8981XBP1\u3002\u4e00\u822c\u53ef\u80fd\u8ba4\u4e3aUPR\u589e\u52a0T\u7ec6\u80de\u7684\u9002\u5e94\u6027\u6216\u589e\u52a0\u6811\u7a81\u7ec6\u80de\u7684\u9002\u5e94\u6027\u3002\u4f46\u4e8b\u5b9e\u6070\u6070\u76f8\u53cd\u3002Glimcher\u548c\u5176\u4ed6\u4eba\u65e9\u5148\u5df2\u7ecf\u8868\u660e\u67d0\u4e9b\u80bf\u7624\u4f9d\u8d56\u4e8eXBP1\u9014\u5f84\uff08\u53ca\u5176\u6d3b\u5316\u9176IRE1\uff09\uff0c\u5e76\u4e14\u9776\u5411\u8be5\u9014\u5f84\u7684\u836f\u7269\u53ef\u4ee5\u76f4\u63a5\u963b\u65ad\u80bf\u7624\u751f\u957f\u3002\u4f46\u73b0\u5728\u6709\u53ef\u80fd\u540c\u65f6\u4f7f\u7528\u8fd9\u79cd\u836f\u7269\u6291\u5236\u80bf\u7624\u5e76\u589e\u5f3a\u6297\u80bf\u7624\u514d\u75ab\u529b\u3002\u00a0<\/div>\n<div><\/div>\n<div>Glimcher\u8bf4\uff1a 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Quentis\u57282018\u5e742\u6708\u5b8c\u6210\u4e864800\u4e07\u7f8e\u5143\u7684A\u8f6e\u878d\u8d44\u3002<\/div>\n<div><\/div>\n<div>\u5176\u4ed6\u51e0\u5bb6\u516c\u53f8\u548c\u5b9e\u9a8c\u5ba4\u4e4b\u524d\u8bd5\u56fe\u5c06IRE1\u4f5c\u4e3a\u76f4\u63a5\u6297\u80bf\u7624\u4f5c\u7528\uff0c\u4f46\u6709\u7684\u653e\u5f03\u4e86\u3002\u800cGlimcher\u5728\u514d\u75ab\u4e0a\u7684\u53d1\u73b0\u4e3a\u8fd9\u79cd\u65b9\u6cd5\u6ce8\u5165\u4e86\u65b0\u7684\u4ef7\u503c\u3002 \u4f11\u65af\u987fMD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u764c\u75c7\u751f\u7269\u5b66\u5bb6Albert Koong\u8bf4\uff0c\u514d\u75ab\u7cfb\u7edf\u7684\u6545\u4e8b\u53ea\u662f\u5176\u4e2d\u4e00\u90e8\u5206\uff0c\u4ed6\u7684\u5b9e\u9a8c\u5ba4\u5df2\u7ecf\u5f00\u53d1\u4e86\u597d\u51e0\u79cdIRE1\u6291\u5236\u5242\u3002<\/div>\n<div><\/div>\n<div><\/div>\n<div>\u656c\u8bf7\u5173\u6ce8\u57fa\u56e0\u6167\u5373\u5c06\u62a5\u9053\u7684\u4e0b\u96c6\u6545\u4e8b\u3002<\/div>\n<div><\/div>\n<div><\/div>\n<div>\u5907\u6ce8\uff1a\u4ee5\u4e0a\u7ffb\u8bd1\u81ea\u300aNature Biotechnology\u2019s academic spinouts of 2018\u300b\uff0cNature Biotechnology\u00a0Volume 37 Issue 5, May 2019\u3002\u6211\u4eec\u529b\u6c42\u5ba2\u89c2\u3001\u51c6\u786e\u7ffb\u8bd1\uff0c\u4e0d\u5c3d\u4e4b\u5904\u8bf7\u4ee5\u539f\u6587\u4e3a\u51c6\u3002\u4ec5\u4f9b\u7814\u7a76\u53c2\u8003\u3002\u673a\u6784\u6216\u76f8\u5173\u516c\u4f17\u53f7\u8f6c\u8f7d\u8bf7\u6ce8\u660e\u7f16\u8bd1\u81ea\u57fa\u56e0\u6167\uff0c\u6b22\u8fce\u4e2a\u4eba\u8f6c\u53d1\u5206\u4eab\u3002<\/div>\n<div><\/div>\n<div>\u7f16\u8f91\uff1aNicole<\/div>\n<div>\u6821\u5bf9\uff1aDamine<\/div>\n<div>\u5ba1\u6838\uff1aMark\u00a0<\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDJkslCjQ2eianQraykAic9cibUichkIGia8EuLp3BVEkck3PVXluOAXw8KiciaicupVhsldIek3LTFOgChcg.png\" alt=\"RmFicvQBAkgDJkslCjQ2eianQraykAic9cibUichkIGia8EuLp3BVEkck3PVXluOAXw8KiciaicupVhsldIek3LTFOgChcg\"\/><\/figure><\/div>\n\n<\/div>\n<div>\u00a0<\/div>\n<div>\u884c\u4e1a\u5206\u6790\u5e08<\/div>\n<div>\u65b0\u5a92\u4f53\u4e3b\u7f16<\/div>\n<div>\u3010\u57fa\u56e0\u6167\u62db\u8058\u3011info@genonet.cn<\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<div>\u3010\u5173\u4e8e\u6211\u4eec\u3011\u57fa\u56e0\u6167\u662f\u4e00\u5bb6\u72ec\u7acb\u7684\u57fa\u56e0\u548c\u6570\u5b57\u751f\u547d\u5065\u5eb7\u4ea7\u4e1a\u521b\u65b0\u670d\u52a1\u5e73\u53f0\uff0c\u6210\u7acb\u4e8e2016\u5e74\uff0c\u56e2\u961f\u6765\u81ea\u884c\u4e1a10\u5e74\u5b9e\u8df5\uff0c\u5efa\u7acb\u4e86\u4f01\u4e1a\u5e93\u3001\u667a\u5e93\u548c\u5a92\u4f53\u5e73\u53f0\uff0c\u4e3a\u91d1\u878d\u673a\u6784\u3001\u653f\u5e9c\u56ed\u533a\u3001\u4f01\u4e1a\u548c\u4e34\u5e8a\u53ca\u79d1\u7814\u4ea7\u4e1a\u5316\u63d0\u4f9b\u4f20\u5a92\u3001\u884c\u7814\u548c\u54a8\u8be2\u7b49\u521b\u65b0\u670d\u52a1\u3002<\/div>\n<div><\/div>\n<div>\u57fa\u56e0\u6167\u662f\u56fd\u5bb6\u53d1\u6539\u59d4\u300a2019\u5e74\u6218\u7565\u6027\u65b0\u5174\u4ea7\u4e1a\u53d1\u5c55\u5c55\u671b\u300b\u7f16\u59d4\u7684\u5355\u4f4d\u3001\u5168\u56fd\u536b\u751f\u4ea7\u4e1a\u4f01\u4e1a\u7ba1\u7406\u534f\u4f1a\u7cbe\u51c6\u533b\u7597\u5206\u4f1a\u7406\u4e8b\u7684\u5355\u4f4d\u3001\u5e7f\u4e1c\u7701\u7cbe\u51c6\u533b\u5b66\u5b66\u4f1a\u653f\u7b56\u7814\u7a76\u5206\u4f1a\u5e38\u59d4\u7684\u5355\u4f4d\u3001\u6df1\u5733\u5e02\u5065\u5eb7\u4ea7\u4e1a\u53d1\u5c55\u4fc3\u8fdb\u4f1a\u526f\u4f1a\u957f\u5355\u4f4d\uff0c\u53d1\u5e03\u4e86<a 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href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247490769&amp;idx=1&amp;sn=36fa39011eb7dd4b148b072d1aadb14c&amp;chksm=eb72ae66dc052770f2c4fc77a777dff121302dbf954b941b54da1d7eaf7eca1fdce86097ee84&amp;scene=21#wechat_redirect\" \/>\u9996\u5c4a\u7ca4\u6e2f\u6fb3\u5927\u6e7e\u533a\u751f\u547d\u5065\u5eb7\u521b\u65b0\u8bba\u575b<\/a>\u3001<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247485809&amp;idx=1&amp;sn=ed212d2f2640470ee7269e9959868dcc&amp;chksm=eb72bbc6dc0532d0fea4edea3a9b2aaf23affe391982bdf651b0322120844c1546119d1d475a&amp;scene=21#wechat_redirect\" \/>\u7b2c\u4e00\u5c4a<\/a>\u548c<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247493932&amp;idx=1&amp;sn=7e68c7e9c7d5b5479e6e4aa540ca569f&amp;chksm=eb715b9bdc06d28d4944c5584d99a68977413620e4dfbb4716376a4b8a5ce7b6b1b1129b5d4f&amp;scene=21#wechat_redirect\" \/>\u7b2c\u4e8c\u5c4a\u57fa\u56e0\u68c0\u6d4b\u8054\u76df\u5927\u4f1a<\/a>\uff0c\u81f4\u529b\u4e8e\u5efa\u7acb\u521b\u65b0\u8fde\u63a5\u5668\u548c\u4ea7\u4e1a\u4fe1\u606f\u5927\u6570\u636e\u5e73\u53f0\u3002<\/div>\n<div><\/div>\n<div>\u6b22\u8fce\u673a\u6784\u3001\u5b66\u4f1a\u53ca\u8054\u76df\u5408\u4f5c\uff0c\u8de8\u754c\u878d\u5408\uff0c\u8d4b\u80fd\u521b\u65b0\uff08\u8054\u7cfb\u65b9\u5f0f\uff1ainfo@genonet.cn, 400-088-7466\uff09\u3002<\/div>\n<div><\/div>\n<div><\/div>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDwDDlibn6LGMERd60A1XgibkVTEVrPEb1EoTK1HnjticKMtrzWS4eyuZgibs4H2ErBL6cp0GRTKvEAkg.jpeg\" 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