\n![\"RmFicvQBAkgCuC54K47siaoibvbClYbpoQdmoEA7Yo9T0l4l5c9wsK8DWv13zXvBYojNDUX4HpbxOEe8enSicCuVVg\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCuC54K47siaoibvbClYbpoQdmoEA7Yo9T0l4l5c9wsK8DWv13zXvBYojNDUX4HpbxOEe8enSicCuVVg.gif\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n<\/div>\n
\u751f\u547d\u63a2\u54e8<\/div>\n
\u751f\u547d\u79d1\u6280\u524d\u6cbf\u8d44\u8baf<\/div>\n
<\/div>\n
\u5173\u952e\u8bcd\/\u8d28\u8c31 \u4ea7\u4e1a\u8054\u76df \u7f16\u8005\/\u57fa\u56e0\u6167<\/div>\n
<\/div>\n
2019\u5e745\u670830\u65e5\uff0c\u201c\u4e34\u5e8a\u8d28\u8c31\u7814\u7a76\u4e0e\u4ea7\u4e1a\u8054\u76df\u201d\u5728\u6df1\u5733\u6b63\u5f0f\u6210\u7acb\uff0c\u7531\u5f20\u7389\u594e\u9662\u58eb\u62c5\u4efb\u987e\u95ee\u56e2\u4e3b\u5e2d\uff0c\u5e9c\u4f1f\u7075\u6559\u6388\u4efb\u7406\u4e8b\u957f\u3002<\/div>\n
<\/div>\n
<\/div>\n
\n\n
\n![\"RmFicvQBAkgC0S4LCIzwibhofH2nGGV80tDrEwoaoQM2VV9N6CLRjRETp4nTHIfzQkoFNOOOkWsakm9icsoxbkxcQ\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgC0S4LCIzwibhofH2nGGV80tDrEwoaoQM2VV9N6CLRjRETp4nTHIfzQkoFNOOOkWsakm9icsoxbkxcQ.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u56fe1\uff1a\u8bba\u575b\u4e0e\u4f1a\u5609\u5bbe\u5408\u5f71 \uff08\u6765\u6e90\uff1a\u54c1\u751f\u5065\u5eb7\uff0c\u5df2\u6388\u6743\uff09<\/div>\n
2019\u5e745\u670830\u65e5\uff0c\u5728\u6df1\u5733\u53ec\u5f00\u7684\u201c\u4e2d\u56fd\u7814\u7a76\u578b\u533b\u9662\u5b66\u4f1a\u68c0\u9a8c\u4e13\u4e1a\u59d4\u5458\u4f1a\u5e74\u4f1a\u66a82019\u5e74\u56fd\u9645\u68c0\u9a8c\u533b\u5b66\u9ad8\u5cf0\u8bba\u575b\u201d\u4e2d\u9996\u6b21\u5f00\u8bbe\u4e86\u201c\u4e34\u5e8a\u8d28\u8c31\u65b0\u6280\u672f\u8bba\u575b\u201d\uff0c\u7531\u4e2d\u56fd\u7814\u7a76\u578b\u533b\u9662\u5b66\u4f1a\u68c0\u9a8c\u4e13\u4e1a\u59d4\u5458\u4f1a\u4e3b\u529e\uff0c\u54c1\u751f\u533b\u5b66\u516c\u53f8\u627f\u529e\uff0c\u5438\u5f15\u4e86\u8d85\u8fc7200\u4f4d\u8d28\u8c31\u6280\u672f\u548c\u68c0\u9a8c\u533b\u5b66\u7684\u4e34\u5e8a\u3001\u79d1\u7814\u548c\u4ea7\u4e1a\u4ee3\u8868\u53c2\u4e0e\u3002<\/div>\n\n
\n![\"RmFicvQBAkgC0S4LCIzwibhofH2nGGV80tvfLdibZ5anRrqe1AtRfGTq4Juueicx5Jrhc9YibJicwwUoQ09H8iaXKy37g\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgC0S4LCIzwibhofH2nGGV80tvfLdibZ5anRrqe1AtRfGTq4Juueicx5Jrhc9YibJicwwUoQ09H8iaXKy37g.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u56fe3\uff1a\u201c\u4e34\u5e8a\u8d28\u8c31\u7814\u7a76\u4e0e\u4ea7\u4e1a\u8054\u76df\u201d\u6210\u7acb\u4eea\u5f0f\uff0c\uff08\u7167\u7247\u6765\u6e90\uff1a\u54c1\u751f\u5065\u5eb7\uff0c\u5df2\u6388\u6743\uff09<\/div>\n
\u4f1a\u4e0a\u201c\u4e34\u5e8a\u8d28\u8c31\u7814\u7a76\u4e0e\u4ea7\u4e1a\u8054\u76df\u201d\u6b63\u5f0f\u5ba3\u5e03\u6210\u7acb\uff0c\u7531\u5f20\u7389\u594e\u9662\u58eb\u62c5\u4efb\u987e\u95ee\u56e2\u4e3b\u5e2d\uff0c\u5e9c\u4f1f\u7075\u6559\u6388\u4efb\u7406\u4e8b\u957f\u3002\u4e34\u5e8a\u8d28\u8c31\u7814\u7a76\u4e0e\u4ea7\u4e1a\u8054\u76df\u5c06\u8d2f\u5f7b\u548c\u6267\u884c\u56fd\u5bb6\u7cbe\u51c6\u533b\u7597\u6218\u7565\uff0c\u63a8\u52a8\u4e34\u5e8a\u8d28\u8c31\u6280\u672f\u548c\u5e94\u7528\u7684\u89c4\u8303\u5316\u3001\u6807\u51c6\u5316\uff0c\u5f15\u9886\u4e2d\u56fd\u4e34\u5e8a\u8d28\u8c31\u4ea7\u4e1a\u7684\u53d1\u5c55\uff0c\u66f4\u597d\u670d\u52a1\u68c0\u9a8c\u533b\u5b66\uff0c\u4e3a\u4eba\u7c7b\u5065\u5eb7\u4e8b\u4e1a\u505a\u51fa\u66f4\u591a\u7684\u8d21\u732e\u3002<\/div>\n
\u00a0<\/div>\n
\u4f1a\u8bae\u7b14\u8bb0<\/div>\n
\u4e3b\u9898\u62a5\u544a\u5609\u5bbe\u5305\u62ec\uff1a<\/div>\n
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\u5e9c\u4f1f\u7075\u6559\u6388\uff08\u4e2d\u56fd\u7814\u7a76\u578b\u533b\u9662\u5b66\u4f1a\u68c0\u9a8c\u533b\u5b66\u4e13\u4e1a\u59d4\u5458\u4f1a\u4e3b\u4efb\u59d4\u5458\u3001\u9646\u519b\u519b\u533b\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\uff09<\/div>\n
\u9ec4\u5c71\u6559\u6388\uff08\u8d35\u5dde\u7701\u4e34\u5e8a\u68c0\u9a8c\u4e2d\u5fc3\u526f\u4e3b\u4efb\uff09<\/div>\n
\u90d1\u78ca\u6559\u6388\uff08\u5357\u65b9\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5357\u65b9\u533b\u9662\u68c0\u9a8c\u79d1\u4e3b\u4efb\uff09<\/div>\n
\u5f20\u771f\u8def\u6559\u6388\uff08\u6b66\u6c49\u4e9a\u6d32\u5fc3\u810f\u75c5\u533b\u9662\u96c6\u56e2\u68c0\u9a8c\u4e2d\u5fc3\u4e3b\u4efb\uff09<\/div>\n
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\u6c83\u7279\u4e16\u516c\u53f8\u3001SCIEX\u516c\u53f8\u3001\u5c9b\u6d25\u516c\u53f8\u7b49\u4e34\u5e8a\u8d28\u8c31\u4ea7\u4e1a\u5c4a\u4ee3\u8868<\/div>\n
\u00a0<\/div>\n
\u5f20\u7389\u594e\u9662\u58eb\uff1a\u300a\u591a\u7ec4\u5b66\u4e34\u5e8a\u5206\u6790\u65b9\u6cd5\u8fdb\u5c55\u300b<\/div>\n\n
\n![\"RmFicvQBAkgC0S4LCIzwibhofH2nGGV80t1hqd9gAiazz85icTmrCfoDxBmZQsIR53vR5JrzcbzB8cxXOOz36wHqww\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgC0S4LCIzwibhofH2nGGV80t1hqd9gAiazz85icTmrCfoDxBmZQsIR53vR5JrzcbzB8cxXOOz36wHqww.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u56fe4\uff1a\u4e2d\u56fd\u79d1\u5b66\u9662\u9662\u58eb\u3001\u4e2d\u56fd\u8272\u8c31\u8d28\u8c31\u9886\u57df\u9886\u519b\u4eba\u3001\u4e34\u5e8a\u8d28\u8c31\u7814\u7a76\u4e0e\u4ea7\u4e1a\u8054\u76df\u987e\u95ee\u56e2\u4e3b\u5e2d\u5f20\u7389\u594e\u9662\u58eb\uff08\u7167\u7247\u6765\u6e90\uff1a\u54c1\u751f\u5065\u5eb7\uff0c\u5df2\u6388\u6743\uff09<\/div>\n
1. \u4eba\u7c7b\u86cb\u767d\u7ec4\u5b66\u7684\u7814\u7a76\u8fdb\u5c55<\/div>\n
\u5f20\u7389\u594e\u9662\u58eb\u9996\u5148\u56de\u987e\u4e86\u4ece\u7cbe\u51c6\u533b\u7597\u3001\u57fa\u56e0\u7ec4\u5230\u86cb\u767d\u8d28\u7ec4\u7814\u7a76\u7684\u8fdb\u5c55\u30021995\u5e74\u63d0\u51fa\u6982\u5ff5\uff0c2010\u5e74\u201c\u4eba\u7c7b\u86cb\u767d\u7ec4\u5b66\u7814\u7a76\u201d\u542f\u52a8\u3002\u5728\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8349\u56fe\u53d1\u5e03\u768413\u5e74\u540e\u76842014\u5e74Nature\u53d1\u8868\u201c\u4eba\u7c7b\u86cb\u767d\u8d28\u7ec4\u5b66\u8349\u56fe\u201d\u6587\u7ae0\uff0c\u753120\u5bb6\u5355\u4f4d72\u4eba\u901a\u529b\u534f\u4f5c\u5b8c\u6210\uff0c\u9274\u5b9a\u4e8617294\u4e2a\u57fa\u56e0\u9501\u8868\u8fbe\u51fa\u6765\u7684\u86cb\u767d\u8d28\u30022015\u5e74Uhlen\u7b49\u4eba\u5bf9\u5176\u4e2d90%\u7684\u7f16\u7801\u86cb\u767d\u8fdb\u884c\u4e86\u5b9a\u4f4d\u3002\u53d1\u73b050%\u5728\u7ec4\u7ec7\u4e2d\u5171\u540c\u8868\u8fbe\u3002\u4e2d\u56fd\u4eba\u7c7b\u86cb\u767d\u7ec4\u5b66\u8ba1\u5212\u662f2014\u5e74\u542f\u52a8\uff0c\u57282018\u5e74\u57fa\u672c\u5b8c\u6210\u3002\u5b8c\u62101\u4e07\u4e2a\u86cb\u767d\uff0c\u65f6\u95f4\u53ef\u4ee5\u4ece2013\u5e74\u768436\u4e2a\u5c0f\u65f6\u964d\u4f4e\u52307\u4e2a\u5c0f\u65f6\u30022019\u5e74\u8d3a\u798f\u521d\u9662\u58eb\u53d1\u8868\u86cb\u767d\u7ec4\u53d1\u73b0\u809d\u764c\u65e9\u7b5b\u9776\u70b9\uff1bFDA\u6279\u51c6\u4e86\u552f\u4e00\u901a\u8fc7\u86cb\u767d\u7ec4\u7ec4\u5b66\u6280\u672f\u7b5b\u9009\u7684\u751f\u7269\u6807\u5fd7\u7269\u7ec4\u5408\u3002<\/div>\n
2.\u65b9\u6cd5\u5b66\u8fdb\u5c55<\/div>\n
1\uff09\u5168\u81ea\u52a8\u86cb\u767d\u8d28\u6837\u54c1\u9884\u5904\u7406\uff0c\u65f6\u95f4\u4e0a\u76f8\u6bd4Mann\u56e2\u961f\u76842h\uff0c\u53ea\u9700\u898120min\u3002 2\uff09\u5bfb\u627e\u4eba\u7c7b\u86cb\u767d\u8d28\u7ec4\u4e2d\u7684\u201c\u4e22\u5931\u7684\u86cb\u767d\u201d\uff082948\u4e2a\uff09\u3002\u5176\u4e2d50%\u7ea6\u4e3a\u819c\u86cb\u767d\u3002\u9996\u6b21\u63d0\u51fa\u57fa\u4e8e\u79bb\u5b50\u6db2\u4f53\u7684\u819c\u86cb\u767d\u8d28\u8d28\u7ec4\u63d0\u53d6\u65b0\u65b9\u6cd5\u3002\u627e\u5230\u4e8626\u4e2a\u201c\u4e22\u5931\u7684\u86cb\u767d\u201d\u3002<\/div>\n
3. \u5e94\u7528<\/div>\n
\u590d\u65e6\u5927\u5b66\u5408\u4f5cPM2.5\u66b4\u9732\u4eba\u7fa4\u8840\u6d46\u5dee\u5f02\u86cb\u767d\u8d28\uff0c\u53d1\u73b0\u708e\u75c7\u3001\u80ba\u90e8\u611f\u67d3\u7684\u5dee\u5f02\u86cb\u767d\u8d28\uff1b\u7cd6\u5c3f\u75c5\u5e76\u53d1\u89c6\u7f51\u819c\u75c5\u53d8\u60a3\u8005\u8840\u6d46\u86cb\u767d\u8d28\u7ec4\u5206\u6790\uff1b\u9776\u5411LIF\u4ecb\u5bfc\u7684\u65c1\u5206\u6ccc\u76f8\u4e92\u4f5c\u7528\u7528\u4e8e\u80f0\u817a\u764c\u7684\u6cbb\u7597\u8fdb\u5165\u4e00\u671f\u4e34\u5e8a\uff1b\u5728\u6291\u90c1\u75c7\u3001\u900f\u6790\u75c5\u7b49\u75be\u75c5\u8bca\u65ad\u3001\u6cbb\u7597\u9886\u57df\u7684\u6700\u65b0\u8fdb\u5c55\u3002\u00a0<\/div>\n
\u00a0<\/div>\n
\u5e9c\u4f1f\u7075\u6559\u6388\uff1a\u300a\u738b\u8005\u8363\u8000\u2014\u2014\u8d28\u8c31\u68c0\u9a8c4.0\u63a8\u52a8\u7cbe\u51c6\u8bca\u65ad\u65b0\u53d8\u9769\u300b<\/div>\n\n
\n![\"640?wx_fmt=jpeg\"\/](\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/RmFicvQBAkgC0S4LCIzwibhofH2nGGV80tZsQnic9an9btuq8xBhMrFRPOIibiaPZmibiakYAHgX8vdmgfD9KOkqIia4iaw\/640?wx_fmt=jpeg\")
<\/figure><\/div>\n\n
\u56fe5\uff1a\u4e2d\u56fd\u4eba\u6c11\u89e3\u653e\u519b\u533b\u5b66\u79d1\u5b66\u59d4\u5458\u4f1a\u68c0\u9a8c\u533b\u5b66\u4e13\u4e1a\u59d4\u5458\u4f1a\u4e3b\u4efb\u59d4\u5458\u3001\u4e2d\u56fd\u7814\u7a76\u578b\u533b\u9662\u5b66\u4f1a\u68c0\u9a8c\u533b\u5b66\u4e13\u4e1a\u59d4\u5458\u4f1a\u4e3b\u4efb\u59d4\u5458\u3001\u4e2d\u534e\u533b\u5b66\u4f1a\u68c0\u9a8c\u533b\u5b66\u5206\u4f1a\u526f\u4e3b\u4efb\u59d4\u5458\u3001\u4e34\u5e8a\u8d28\u8c31\u7814\u7a76\u4e0e\u4ea7\u4e1a\u8054\u76df\u7406\u4e8b\u957f\u5e9c\u4f1f\u7075\u6559\u6388\uff08\u7167\u7247\u6765\u6e90\uff1a\u54c1\u751f\u5065\u5eb7\uff0c\u5df2\u6388\u6743\uff09<\/div>\n
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\u00a0<\/div>\n
\u4e34\u5e8a\u8d28\u8c31\u68c0\u9a8c\u6b63\u8fdb\u5165\u5230\u57fa\u56e0\u7ec4\u5b66\u3001\u86cb\u767d\u8d28\u7ec4\u5b66\u3001\u4ee3\u8c22\u7ec4\u5b66\u7b49\u591a\u7ec4\u5b66\u6574\u5408\u5206\u6790\u7684\u7cbe\u786e\u8bca\u65ad\u201c4.0\u201d\u9636\u6bb5\uff0c\u5e94\u7528\u4e8e\u80bf\u7624\u8bca\u65ad\u3001\u4f20\u67d3\u75c5\u8bca\u65ad\u3001\u9057\u4f20\u75c5\u5206\u6790\u3001\u4ee3\u8c22\u75be\u75c5\u5206\u6790\u3002\u5e9c\u4f1f\u7075\u6559\u6388\u8868\u793a\uff0c\u4e34\u5e8a\u8d28\u8c31\u7ed3\u5408\u5927\u6570\u636e\u3001\u4eba\u5de5\u667a\u80fd\u6280\u672f\u5c06\u8ba9\u201c\u8d28\u8c31\u201d\u53d8\u201c\u667a\u8c31\u201d\uff0c\u5f00\u542f\u4e34\u5e8a\u8d28\u8c31\u5e94\u7528\u65b0\u7bc7\u7ae0\uff0c\u5b9e\u73b0\u4e34\u5e8a\u8d28\u8c31\u201c\u4e2d\u56fd\u68a6\u201d\u3002\u00a0<\/div>\n
\u5e9c\u4f1f\u7075\u6559\u6388\u8fd8\u4ecb\u7ecd\u4e86MOLDI-ToF\u5e73\u53f0\uff0c\u68c0\u6d4bctDNA\uff0c\u7075\u654f\u5ea6\u9ad8\uff0c\u53ef\u68c0\u6d4b0.5%\u7684somatic\u7a81\u53d8\u4ee5\u53ca\u8840\u6e05\u86cb\u767d\u591a\u80bd\u7ec4\u5206\u7c7b\u68c0\u6d4b\u7b49\u6280\u672f\uff0c\u5c55\u793a\u4e86\u4ee3\u8c22\u7ec4\u7684\u5e7f\u6cdb\u5e94\u7528\u573a\u666f\u3002<\/div>\n
\u00a0<\/div>\n
\u6210\u6653\u4eae\u535a\u58eb\uff08\u54c1\u751f\u533b\u5b66\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u957f\u517c\u603b\u88c1\uff09<\/div>\n\n
\n![\"RmFicvQBAkgC0S4LCIzwibhofH2nGGV80txzWKmUIIiapjmzck8lGSUI2oBicwLno2PI206FvS6b9IQueO6xQIqtkw\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgC0S4LCIzwibhofH2nGGV80txzWKmUIIiapjmzck8lGSUI2oBicwLno2PI206FvS6b9IQueO6xQIqtkw.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u56fe6\uff1a\u54c1\u751f\u533b\u5b66\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u957f\u517c\u603b\u88c1\u3001\u4e34\u5e8a\u8d28\u8c31\u7814\u7a76\u4e0e\u4ea7\u4e1a\u8054\u76df\u5e38\u52a1\u526f\u7406\u4e8b\u957f \u6210\u6653\u4eae\u535a\u58eb\uff08\u7167\u7247\u6765\u6e90\uff1a\u54c1\u751f\u5065\u5eb7\uff0c\u5df2\u6388\u6743\uff09<\/div>\n
\u6210\u6653\u4eae\u535a\u58eb\u5728\u5927\u4f1a\u81f4\u8f9e\u4e2d\u8868\u793a\uff0c\u4e34\u5e8a\u8d28\u8c31\u68c0\u9a8c\u5df2\u5230\u4e86\u5feb\u901f\u53d1\u5c55\u9636\u6bb5\uff0c\u4e34\u5e8a\u8d28\u8c31\u7814\u7a76\u4e0e\u4ea7\u4e1a\u8054\u76df\u7684\u6210\u7acb\uff0c\u4e3a\u6574\u4e2a\u4e34\u5e8a\u8d28\u8c31\u4ea7\u4e1a\u63d0\u4f9b\u4e86\u4e00\u4e2a\u4ea4\u6d41\u5408\u4f5c\u7684\u5e73\u53f0\uff0c\u8d28\u8c31\u6280\u672f\u3001\u68c0\u9a8c\u533b\u5b66\u7684\u4e13\u5bb6\u5b66\u8005\u3001\u4eea\u5668\u5382\u5546\u3001\u5e94\u7528\u670d\u52a1\u5546\u7b49\u884c\u4e1a\u540c\u76df\u8054\u5408\u8d77\u6765\uff0c\u5171\u540c\u63a8\u8fdb\u4e34\u5e8a\u8d28\u8c31\u5728\u4e2d\u56fd\u7684\u4ea7\u4e1a\u5316\u8fdb\u7a0b\uff0c\u5f15\u9886\u884c\u4e1a\u53d1\u5c55\uff0c\u63a8\u52a8\u6280\u672f\u521b\u65b0\uff0c\u8ba9\u8d28\u8c31\u6280\u672f\u66f4\u597d\u5730\u4e3a\u68c0\u9a8c\u533b\u5b66\u670d\u52a1\u3002\u00a0<\/div>\n
\u00a0<\/div>\n
\u9ec4\u5c71\u6559\u6388\uff1a\u300a\u8d28\u8c31\u6280\u672f\u5728\u5185\u5206\u6ccc\u75be\u75c5\u68c0\u6d4b\u7684\u5e94\u7528\u4ecb\u7ecd\u300b<\/div>\n\n
\n![\"RmFicvQBAkgC0S4LCIzwibhofH2nGGV80t2VNiciaZwzE6BUctn7icpUiaf6Mib2OoLxb1wk0enrdmfIx0EGystHbemXw\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgC0S4LCIzwibhofH2nGGV80t2VNiciaZwzE6BUctn7icpUiaf6Mib2OoLxb1wk0enrdmfIx0EGystHbemXw.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u56fe7\uff1a\u4e2d\u534e\u533b\u5b66\u4f1a\u68c0\u9a8c\u5206\u4f1a\u5168\u56fd\u59d4\u5458\u3001\u8d35\u5dde\u7701\u4e34\u5e8a\u68c0\u9a8c\u4e2d\u5fc3\u526f\u4e3b\u4efb\u3001\u4e34\u5e8a\u8d28\u8c31\u7814\u7a76\u4e0e\u4ea7\u4e1a\u8054\u76df\u526f\u7406\u4e8b\u957f\u9ec4\u5c71\u6559\u6388\uff08\u7167\u7247\u6765\u6e90\uff1a\u54c1\u751f\u5065\u5eb7\uff0c\u5df2\u6388\u6743\uff09<\/div>\n
\u9ec4\u5c71\u6559\u6388\u6307\u51fa\uff0c\u8d28\u8c31\u6280\u672f\u5c31\u50cf\u662f\u5fae\u89c2\u4e16\u754c\u7684\u201c\u79e4\u201d\uff0c\u662f\u5bf9\u5c0f\u5206\u5b50\u7269\u8d28\u5b9a\u6027\u3001\u5b9a\u91cf\u7684\u4e00\u628a\u5229\u5668\uff0c\u5728\u7406\u8bba\u4e0a\u53ef\u76d1\u6d4b\u5230\u5355\u4e2a\u5177\u4f53\u7684\u6297\u539f\u51b3\u5b9a\u65cf\u6216\u5355\u4e2a\u6c28\u57fa\u9178\u3002\u968f\u7740\u8d28\u8c31\u6280\u672f\u7684\u84ec\u52c3\u53d1\u5c55\uff0c\u5728\u4e34\u5e8a\u5b9e\u9a8c\u5ba4\u7684\u5e94\u7528\u5df2\u7ecf\u8d8a\u6765\u8d8a\u5e7f\u6cdb\uff0c\u5e02\u573a\u524d\u666f\u5e7f\u9614\u3002\u00a0<\/div>\n
\u4ee5\u57fa\u56e0\u7ec4\u5b66\u3001\u86cb\u767d\u7ec4\u5b66\u3001\u4ee3\u8c22\u7ec4\u6280\u672f\u4e3a\u5185\u5206\u6ccc\u75be\u75c5\u8bca\u7597\u63d0\u4f9b\u4e86\u65b0\u7684\u5206\u5b50\u9014\u5f84\u548c\u836f\u7269\u5206\u5b50\u9776\u70b9\u548c\u53d1\u75c5\u673a\u5236\u7814\u7a76\u4f9d\u636e\u3002<\/div>\n
\u5e76\u5206\u4eab\u4e86\u5728\u8d28\u8c31\u6280\u672f\u5728\u7532\u72b6\u817a\u6fc0\u7d20\u68c0\u6d4b\u3001\u6027\u6fc0\u7d20\u68c0\u6d4b\u3001CAH\u68c0\u6d4b\u3001PA\u68c0\u6d4b\u3001CS\u68c0\u6d4b\u3001PPGL\u68c0\u6d4b\u7b49\u5185\u5206\u6ccc\u75be\u75c5\u7b5b\u67e5\u7684\u5e94\u7528\u60c5\u51b5\u3002\u76ee\u524d\u5185\u5206\u6ccc\u6fc0\u7d20\u68c0\u9a8c\u4e3b\u8981\u65b9\u6cd5\u5305\u62ec\uff1a<\/div>\n
1\uff09\u751f\u7269\u5b66\u6d4b\u5b9a\uff08\u7ec6\u83cc\u6291\u5236\u6cd5\u3001\u7ec6\u80de\u751f\u7269\u5316\u5b66\u65b9\u6cd5\u3001\u79bb\u4f53\u7ec6\u80de\u57f9\u517b\u6d4b\u5b9a\u751f\u7269\u6d3b\u6027\u6cd5\uff09\uff1b<\/div>\n
2\uff09\u514d\u75ab\u4fa7\u5b9a\u6cd5\uff08\u51dd\u96c6\u8bd5\u9a8c\u3001\u514d\u75ab\u6bd4\u6d4a\u53d1\u3001\u6807\u8bb0\u514d\u75ab\u6d4b\u5b9a\uff09\uff1b<\/div>\n
3\uff09\u5206\u5b50\u68c0\u6d4b\u6280\u672f\uff08\u751f\u7269\u82af\u7247\u3001\u57fa\u56e0\u68c0\u6d4b\u3001\u8d28\u8c31\u6280\u672f\uff09\u3002<\/div>\n
\u6027\u6fc0\u7d20\u68c0\u6d4b\u4e0a\uff0c\u8d28\u8c31\u6280\u672f\u53ef\u4ee5\u5e94\u7528\u4e8e\u68c0\u6d4b\u96cc\u4e8c\u9187\u7b49\u542b\u91cf\u6bd4\u8f83\u4f4e\u7684\u6fc0\u7d20\uff1bLC-MS\/MS\u7528\u4e8eCAH\u4e8c\u7ea7\u7b5b\u67e5\u964d\u4f4e\u5047\u9633\u6027\uff0c\u4e3a\u8bca\u65ad\u5206\u578b\u63d0\u4f9b\u51c6\u786e\u4fe1\u606f\uff1b\u5bf9PA\uff08\u539f\u53d1\u6027\u919b\u56fa\u916e\u589e\u591a\u75c7\uff09\u53ef\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u66ff\u4ee3APR\uff1b\u4ee5\u53caCS\u68c0\u6d4b\u548cPPGL\u68c0\u6d4b\u7b49\u3002<\/div>\n
\u5c55\u671b\u672a\u6765\uff0c\u884c\u4e1a\u5bf9\u8d28\u8c31\u7684\u8ba4\u77e5\u4e0d\u591f\u3001\u4eba\u624d\u4f9b\u5e94\u4e0d\u8db3\uff1b\u6b64\u5916\uff0c\u7f3a\u4e4f\u7ecfFDA\u6279\u51c6\u7684\u8bd5\u5242\u76d2\uff1b\u5176\u6b21\uff0c\u8d28\u8c31\u4eea\u7684\u81ea\u52a8\u5316\u53ca\u5c0f\u578b\u5316\u53ef\u5927\u5927\u63d0\u9ad8\u5b9e\u7528\u6027\u3002<\/div>\n
\u00a0<\/div>\n
\u90d1\u78ca\u6559\u6388\uff1a\u300a\u8d28\u8c31\u6280\u672f\u5728EVs\u68c0\u6d4b\u4e2d\u7684\u5e94\u7528\u300b<\/div>\n\n
\n![\"RmFicvQBAkgC0S4LCIzwibhofH2nGGV80tFS4B0Y4icoHl8PzsNygOB6vCicaJKdyooQbfFsP9K0NuwQBfj0hw4EPg\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgC0S4LCIzwibhofH2nGGV80tFS4B0Y4icoHl8PzsNygOB6vCicaJKdyooQbfFsP9K0NuwQBfj0hw4EPg.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u56fe8\uff1a\u5e7f\u4e1c\u7701\u533b\u5b66\u4f1a\u68c0\u9a8c\u5206\u4f1a\u4e3b\u4efb\u59d4\u5458\u3001\u5357\u65b9\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5357\u65b9\u533b\u9662\u68c0\u9a8c\u79d1\u4e3b\u4efb\u3001\u4e34\u5e8a\u8d28\u8c31\u7814\u7a76\u4e0e\u4ea7\u4e1a\u8054\u76df\u526f\u7406\u4e8b\u957f\u90d1\u78ca\u6559\u6388\u00a0\uff08\u7167\u7247\u6765\u6e90\uff1a\u54c1\u751f\u5065\u5eb7\uff0c\u5df2\u6388\u6743\uff09<\/div>\n
\u90d1\u78ca\u6559\u6388\u5e26\u6765\u7ec6\u80de\u5916\u56ca\u6ce1\uff08EVs\uff09\u7684\u7efc\u5408\u4ecb\u7ecd\u548c\u524d\u6cbf\u8fdb\u5c55\u3002<\/div>\n
EVs\u5305\u62ec\u5916\u6ccc\u4f53\u3001\u5fae\u6ce1\u3001\u51cb\u4ea1\u5c0f\u4f53\u7b49\uff0c\u00a0\u5e7f\u6cdb\u5b58\u5728\u4e8e\u4eba\u4f53\u4f53\u6db2\u4e2d\uff0c\u5728\u7ec6\u80de\u95f4\u4f20\u9012\u4fe1\u606f\u3002EVs\u53ef\u4ee5\u4f5c\u4e3a\u8bb8\u591a\u4e34\u5e8a\u8bca\u65ad\u7684\u751f\u7269\u6807\u8bb0\u7269\uff0c\u4ece1946\u5e74Chargaff\u548cWest\u89c2\u5bdf\u5230Evs\u52302016\u5e74ExoDx,lnc\u7684\u8bca\u65ad\u8bd5\u5242\u76d2\u83b7FDA\u6279\u51c6\u8fdb\u884c\u524d\u5217\u817a\u764c\u7b5b\u67e5\uff0cEvs\u5728\u4e34\u5e8a\u7684\u5e94\u7528\u53d1\u5c55\u8fc5\u901f\u3002\u8d28\u8c31\u6280\u672f\u5219\u4e3aEVs\u76f8\u5173\u7684\u86cb\u767d\u7ec4\u5b66\u548c\u4ee3\u8c22\u7ec4\u5b66\u7814\u7a76\u63d0\u4f9b\u6280\u672f\u652f\u6491\u3002\u00a0<\/div>\n
EVs\u7684\u7814\u7a76\u7b56\u7565\u5305\u62ec\u6837\u54c1\u6536\u96c6\u3001\u5206\u79bb\u7eaf\u5316\uff08\u5c3a\u5bf8\u6392\u963b\u3001\u78c1\u73e0\u6355\u83b7\u7b49\uff09 \u3001\u9274\u5b9a\uff08\u7535\u955c\u7b49\u6280\u672f\uff09 \u3001\u5185\u5bb9\u7269\u5206\u6790\uff08\u6838\u9178\u3001\u8102\u7c7b\u3001\u86cb\u767d\u8d28\uff09 \u548c\u68c0\u6d4b\u6280\u672f\uff08\u7c92\u5f84\u5206\u5e03\u53ca\u6570\u91cf\u68c0\u6d4b\u3001\u86cb\u767d\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u3001\u6297\u4f53\u6355\u83b7\u3001\u9002\u914d\u4f53\u6355\u83b7\uff09\u3002\u7eb3\u7c73\u6d41\u5f0f\u68c0\u6d4b\u4eea\u53ef\u7528\u4e8e\u68c0\u6d4b\u3002\u7814\u7a76\u6307\u5357\/\u673a\u6784\u5305\u62ecISEV\u3001ISTH\u548cAHA\u7b49\u3002<\/div>\n
\u5916\u6ccc\u4f53\u53ef\u5e7f\u6cdb\u7528\u4e8e\u8bca\u65ad\u6807\u5fd7\u7269\u3002\u4f8b\u5982GPC1+ exosome\u7528\u4e8e\u65e9\u671f\u80f0\u817a\u764c\u8bca\u65ad \uff1b\u8840\u6db2\u5faa\u73afExosomal PD-L1\u7528\u4e8e\u533a\u5206\u5065\u5eb7\u4eba\u548c\u9ed1\u8272\u7d20\u7624\u75c5\u4eba\uff0c\u4ee5\u53ca\u6307\u5bfc\u4e34\u5e8a\u7528\u836f\u548c\u9884\u540e\u3002<\/div>\n
EVs\u8bca\u65ad\u6807\u5fd7\u7269\u7814\u7a76\u5e94\u7528\u7684\u4e3b\u8981\u95ee\u9898\uff1a1\uff09\u5feb\u901f\u7b80\u4fbf\u7684\u63d0\u7eaf\u65b9\u6cd5\uff1b2\uff09\u9274\u5b9a\u5668\u5b98\u6216\u75be\u75c5\u7279\u5f02\u6027\u7684EVs \uff1b3\uff09\u533a\u5206EVs\u529f\u80fd\u4e9a\u7fa4\uff1b 4\uff09\u68c0\u6d4b\u65b9\u6cd5\u6807\u51c6\u5316\u3002<\/div>\n
\u5728\u76f8\u5173\u7814\u7a76\u5de5\u4f5c\u4e0a\uff0c\u90d1\u78ca\u6559\u6388\u4ecb\u7ecd\u4e86\u57fa\u4e8e\u5fae\u6db2\u6ef4\u6280\u672f\u5b9e\u73b0\u5916\u6ccc\u4f53\u7684\u5355\u4e2a\u5206\u6790\u53ca\u7edd\u5bf9\u5b9a\u91cf\uff1b\u8840\u6e05EVs\u86cb\u767d\u8d28\u7ec4\u5b66\u7b5b\u9009\u80ba\u764c\u6807\u5fd7\u7269\uff08Proteomics, 2019\uff09\u7b49\uff1b\u540c\u65f6\u5ba3\u4f20\u4e86\u56fd\u9645\u7ec6\u80de\u5916\u56ca\u6ce1\u534f\u4f1a\uff08ISEV\uff09\u548c\u521b\u529e\u7684JEV\u6742\u5fd7\uff0c\u4eca\u5e74\u5c06\u53ec\u5f00\u4e2d\u56fd\u7ec6\u80de\u5916\u56ca\u6ce1\u7814\u7a76\u534f\u4f1a(CSEV)\u7b2c\u4e09\u5c4a\u5e74\u4f1a\u3002<\/div>\n
\u00a0<\/div>\n
\u5f20\u771f\u8def\u6559\u6388\uff1a\u300a\u8d28\u8c31\u6280\u672f\u5bf9\u65b0\u578b\u53e3\u670d\u6297\u51dd\u836f\uff08DOAC\uff09\u68c0\u6d4b\u7684\u4f18\u52bf\u300b<\/div>\n\n
\n![\"RmFicvQBAkgC0S4LCIzwibhofH2nGGV80tW7BXXRYogd5e6da87NXMQxJp76s02icmc1mJibojtXA0u7PCxezGOjKQ\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgC0S4LCIzwibhofH2nGGV80tW7BXXRYogd5e6da87NXMQxJp76s02icmc1mJibojtXA0u7PCxezGOjKQ.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u56fe9\uff1a\u4e2d\u56fd\u533b\u5e08\u534f\u4f1a\u68c0\u9a8c\u5206\u4f1a\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u4e13\u4e1a\u59d4\u5458\u4f1a\u526f\u4e3b\u4efb\u59d4\u5458\u3001\u6b66\u6c49\u4e9a\u6d32\u5fc3\u810f\u75c5\u533b\u9662\u96c6\u56e2\u68c0\u9a8c\u4e2d\u5fc3\u4e3b\u4efb\u3001\u4e34\u5e8a\u8d28\u8c31\u7814\u7a76\u4e0e\u4ea7\u4e1a\u8054\u76df\u526f\u7406\u4e8b\u957f\u5f20\u771f\u8def\u6559\u6388\uff08\u7167\u7247\u6765\u6e90\uff1a\u54c1\u751f\u5065\u5eb7\uff0c\u5df2\u6388\u6743\uff09<\/div>\n
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