\n![\"RmFicvQBAkgCuC54K47siaoibvbClYbpoQdmoEA7Yo9T0l4l5c9wsK8DWv13zXvBYojNDUX4HpbxOEe8enSicCuVVg\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCuC54K47siaoibvbClYbpoQdmoEA7Yo9T0l4l5c9wsK8DWv13zXvBYojNDUX4HpbxOEe8enSicCuVVg.gif\")
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GeneMail<\/div>\n
\u6570\u5b57\u751f\u547d\u5065\u5eb7\u884c\u4e1a\u7b80\u62a5<\/div>\n
\u5173\u952e\u8bcd\/ \u57fa\u56e0\u7ec4 \u9057\u4f20 \u5fae\u751f\u7269\u7ec4 \u57fa\u56e0\u8868\u8fbe<\/div>\n
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\u4eca\u5929\u662f2019\u5e74\u7684\u7b2c24\u5468\uff0c\u57fa\u56e0\u6167\u4e3a\u60a8\u5206\u4eab\u7b2c74\u671fGeneMail\u7b80\u62a5\uff0c\u6db5\u76d6\u653f\u7b56\/\u79d1\u7814\/\u5e94\u7528\/\u4ea7\u4e1a\u548c\u4f1a\u8bae\u6d3b\u52a8\u7b49\uff0c\u4f9b\u51b3\u7b56\u8005\u6218\u7565\u5236\u5b9a\u53ca\u6295\u878d\u8d44\u53c2\u8003\u3002\u6b22\u8fce\u6295\u7a3f\u548c\u53ca\u62a5\u9053\u5408\u4f5c\uff08info@genonet.cn\uff09<\/div>\n
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\n![\"RmFicvQBAkgAFCaKIYQHMKxibAv2U1oIp9caU6I2CTSc1RI39hSRT4T58biblHBcVaRT9nlhRq1OwxORcNaAcWk5w\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAFCaKIYQHMKxibAv2U1oIp9caU6I2CTSc1RI39hSRT4T58biblHBcVaRT9nlhRq1OwxORcNaAcWk5w.jpeg\")
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<\/figure><\/div>\n\n\u672c\u671f\u56fe\u7247\u5934\u6761\uff1aDNA\u8bc6\u522b\u4eba\u8138\u7814\u7a76\u591a\u5e74\u6765\uff0c\u8fd9\u6b21\u52a0\u5165\u4e86\u65b0\u7684\u5143\u7d20\u63d0\u9ad8\u4e86\u51c6\u786e\u7387\u3002A\uff08\u6027\u522b+\u53c2\u8003\u57fa\u56e0\u7ec4+\u4e2a\u4f53\u57fa\u56e0\u4f4d\u70b9\uff09\u548cB\uff08DNA+BMI+\u5e74\u9f84\uff09\u4e24\u4e2a\u5206\u7c7b\u5668\u5bf9\u4eba\u9762\u90e8\u8bc6\u522b\u7684\u521d\u6b65\u51c6\u786e\u7387\u5206\u522b\u8fbe\u523083\uff05\u548c80\uff05\u3002<\/div>\n
\uff08\u00a0https:\/\/doi.org\/10.1038\/s41467-019-10617-y\uff09<\/div>\n
\u00a0<\/div>\n
\u672c\u671f\u5934\u6761<\/div>\n
1.\u00a0\u897f\u5948\u5c71\u6295\u8d441\u4ebf\u7f8e\u5143\u5efa\u7acbAI\u548c\u7cbe\u51c6\u533b\u5b66\u4e2d\u5fc3<\/div>\n
\u897f\u5948\u5c71\u7684\u4f0a\u574e\u533b\u5b66\u9662\uff08The Icahn School of Medicine at Mount Sinai\uff09\u8ba1\u5212\u57282021\u5e74\u672b\u5728\u66fc\u54c8\u987f\u5f00\u8bbe\u4e00\u4e2a\u4ef7\u503c\u7ea61\u4ebf\u7f8e\u5143\u7684\u4eba\u5de5\u667a\u80fd\u548c\u7cbe\u51c6\u533b\u5b66\u4e2d\u5fc3\u3002\u91cd\u70b9\u5173\u6ce8\u4e09\u4e2a\u5173\u952e\u9886\u57df\uff1a\u5efa\u7acb\u65b0\u7684\u57fa\u56e0\u5065\u5eb7\u4e2d\u5fc3\u3001\u7ec4\u5b66\u548c\u75be\u75c5\u591a\u7ef4\u5efa\u6a21\u548c\u7cbe\u5bc6\u6210\u50cf\uff08\u5f6d\u535a\u793e\uff09\u3002<\/div>\n
\u3010\u62d3\u5c55\u9605\u8bfb\uff1a1968\u5e74\u6210\u7acb\u7684\u897f\u5948\u5c71\u533b\u5b66\u9662\uff0c\u65e9\u57281969\u5e74\u7814\u53d1\u4e86\u7b2c\u4e00\u6b3e\u9057\u4f20\u4fee\u9970\u7684\u75ab\u82d7\uff0c1977\u5e74\u5b8c\u6210\u4e86\u6d41\u611f\u75c5\u6bd2\u6d4b\u5e8f\uff0c2018\u5e74\u542f\u52a8\u4e86\u751f\u7269\u533b\u5b66\u533a\u5757\u94fe\u7814\u7a76\u4e2d\u5fc3\u3002\u897f\u5948\u5c71\u533b\u5b66\u9662\u5728\u8001\u5e74\u533b\u5b66\u65b9\u9762\u8f83\u4e3a\u77e5\u540d\u3002\u3011<\/div>\n
\u00a0<\/div>\n
2. \u6885\u5965\u8bca\u6240\u548c\u518d\u751f\u5143\u5408\u4f5c10\u4e07\u4f8b\u5916\u663e\u5b50\u6d4b\u5e8f\u548c\u57fa\u56e0\u5206\u578b<\/div>\n
Mayo Clinic\uff08\u6885\u5965\u8bca\u6240\uff09\u548cRegeneron Pharmaceuticals\uff08\u518d\u751f\u5143\u5236\u836f\uff09\u5408\u4f5c\uff0c\u5bf9\u60a3\u8005\u768410\u4e07\u4f8bDNA\u6837\u672c\u8fdb\u884c\u5916\u663e\u5b50\u7ec4\u6d4b\u5e8f\u548c\u57fa\u56e0\u5206\u578b\uff0c\u6765\u5206\u6790\u5305\u62ec\u764c\u75c7\u3001\u5fc3\u810f\u75c5\u548c\u7cbe\u795e\u7c7b\u75be\u75c5\u5728\u5185\u7684\u75be\u75c5\u53d1\u751f\u53d1\u5c55\u673a\u5236\u4e0e\u9057\u4f20\u53d8\u5f02\u7684\u5173\u8054\u6027\u3002<\/div>\n
\u3010\u62d3\u5c55\u9605\u8bfb\uff1aRegeneron (NASDAQ:REGN)\u662f\u4e00\u5bb6\u6210\u7acb31\u5e74\u7684\u8de8\u56fd\u836f\u4f01\uff0c2014\u5e74\u4ea6\u57fa\u4e8e\u5916\u663e\u5b50\u6d4b\u5e8f\u670d\u52a1\u53c2\u4e0eGeisinger Health\u7684MyCode\u793e\u533a\u5065\u5eb7\u8ba1\u5212\uff0cDecode Genetics\u548cIntermountain Healthcare\u8ba1\u5212\u65bd\u884cHerediGene\u4eba\u53e3\u5065\u5eb7\u8ba1\u5212\uff0850\u4e07\u540d\u60a3\u8005WGS\uff09\uff0c\u4e0e\u4ee5\u4e0a\u4e8c\u8005\u7c7b\u4f3c\u3002\u503c\u5f97\u56fd\u5185\u501f\u9274\uff0c\u7528\u4e8e\u6807\u51c6\u5efa\u8bbe\u548c\u4ea7\u4e1a\u94fe\u6574\u5408\u3002\u3011<\/div>\n
\u00a0<\/div>\n
3. \u4f1a\u8bae\u63a8\u8350\uff1aNanopore \u5168\u56fd\u6280\u672f\u5de1\u8bb2\uff08adv.\uff09<\/div>\n
2019\u5e749\u6708\uff0cNanopore\u5c06\u5728\u5168\u56fd\u8fdb\u884c\u6280\u672f\u5de1\u8bb2\uff08Nanopore Tech Tour\uff09\uff0c\u5171\u540c\u63a2\u8ba8\u7eb3\u7c73\u5b54\u6d4b\u5e8f\u6280\u672f\u7814\u7a76\u3002\u4f1a\u8bae\u5c06\u5305\u62ec\u5168\u4f53\u4f1a\u8bae\u3001\u5206\u7ec4\u4f1a\u8bae\uff0c\u6f14\u8bb2\u4ee5\u53ca\u79d1\u7814\u6d77\u62a5\u3002\u65f6\u95f4\u4f9d\u6b21\u662f\uff1a9\u670820\u65e5\uff08\u9999\u6e2f\uff09\u30019\u670823\u65e5\uff08\u5317\u4eac\uff09\u30019\u670826\u65e5\uff08\u4e0a\u6d77\uff09\uff08\u8be6\u60c5\u89c1Nanopore\u5b98\u7f51 https:\/\/nanoporetech.com\uff09\u3002<\/div>\n
\u3010\u62d3\u5c55\u9605\u8bfb\uff1a\u9664\u4e86\u719f\u77e5\u7684\u624b\u6301\u5f0fMinION\u3001\u8f83\u9ad8\u901a\u91cf\u7684GridION\u548cPromethION\u7b49\u6d4b\u5e8f\u4eea\u5916\uff0cNanopore\u5df2\u5728\u5b98\u7f51\u4f4e\u8c03\u53d1\u5e03\u81ea\u52a8\u5efa\u5e93\u3001\u6d4b\u5e8f\u5206\u6790\u4e00\u4f53\u673a\u3001\u914d\u7f6e\u5c0f\u578b\u670d\u52a1\u5668\u3001\u4ee5\u53ca\u8fde\u63a5\u624b\u673a\u7684\u6d4b\u5e8f\u4eea\u578b\u7b49\u8bbe\u5907\u3002\u3011<\/div>\n
\u00a0<\/div>\n
4. \u4f1a\u8bae\u63a8\u8350\uff1a2019\u6d4b\u5e8f\u6280\u672f\u548c\u5e94\u7528\u9ad8\u5cf0\u8bba\u575b \uff08adv.\uff09<\/div>\n
\u534e\u5927\u667a\u9020\u5c06\u4e8e2019\u5e746\u670821\u65e5-23\u65e5\u5728\u5317\u4eac\u798f\u670b\u559c\u6765\u767b\u9152\u5e97\uff08\u6d77\u6dc0\u533a\u8fdc\u5927\u8def25\u53f71\u5ea7\uff09\u4e3e\u529e\u201c 2019\u6d4b\u5e8f\u6280\u672f\u548c\u5e94\u7528\u9ad8\u5cf0\u8bba\u575b\u201d\u3002\u53c2\u4e0e\u4e13\u5bb6\u5305\u62ec\u6768\u7115\u660e\u9662\u58eb\u3001Lars Bolund\uff08\u4e39\u9ea6Aarhus\u5927\u5b66\uff09\u3001\u845b\u9882\uff08\u4e2d\u79d1\u9662\u690d\u7269\u7814\u7a76\u6240\uff09\u3001\u5434\u7ee7\u7ea2\uff08\u590d\u65e6\u9644\u5c5e\u773c\u8033\u9f3b\u5589\u79d1\u533b\u9662\uff09\u3001Christopher Mason\uff08MSK\uff09\u3001\u80e1\u6653\u6e58\uff08\u4e2d\u56fd\u519c\u4e1a\u5927\u5b66\uff09\u3001\u5434\u73cd\u82b3\uff08\u534e\u5357\u519c\u4e1a\u5927\u5b66\uff09\u3001\u5362\u6615\uff08CDC\uff09\u3001\u59da\u7c9f\uff08\u4e2d\u56fd\u98df\u54c1\u53d1\u9175\u5de5\u4e1a\u7814\u7a76\u9662\uff09\u7b49\uff08\u8be6\u60c5<\/a>\uff09\u3002<\/div>\n
\u3010\u62db\u52df\u3011GeneMail\u6587\u5b57\/\u8bed\u97f3\u7f16\u8f91\uff08\u53ef\u517c\u804c\uff0c\u5177\u5907\u57fa\u56e0\u884c\u4e1a\u7ecf\u9a8c\uff09\uff0c\u7b80\u5386\u6295\u9012\uff1ainfo@genonet.cn\u3002<\/div>\n
\u00a0<\/div>\n
\u672c\u671f\u76ee\u5f55<\/div>\n
\u653f\u7b56<\/div>\n
1. \u652f\u6301\u793e\u4f1a\u529e\u533b\uff0c9\u6708\u5e95\u524d\u51fa\u53f0\u4e92\u8054\u7f51\u8bca\u7597\u6536\u8d39\u653f\u7b56\u00a0<\/div>\n
2. 6\u670815\u65e5\u8d773700\u5bb6\u533b\u9662\u53d6\u6d88\u533b\u8017\u52a0\u6210\u00a0\u00a0<\/div>\n
3. \u56fd\u5bb6\u836f\u5178\u59d4\u516c\u793a\u300a\u4eba\u7528\u57fa\u56e0\u6cbb\u7597\u5236\u54c1\u603b\u8bba\u8349\u6848\u300b\u00a0<\/div>\n
4. 17\u79cd\u6297\u764c\u836f\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\u8c08\u5224\uff0c\u5e73\u5747\u964d\u4ef756.7%<\/div>\n
5.\u00a0\u7f8e\u56fdNIH\u5ba3\u5e03\u5c06\u8fdb\u884c\u80be\u810f\u75be\u75c5\u3001\u6291\u90c1\u75c7\u7b49\u57fa\u56e0\u7ec4\u533b\u5b66\u7814\u7a76<\/div>\n
6.\u00a0\u79d1\u6280\u90e8\u53d1\u5e03\u201c\u5408\u6210\u751f\u7269\u5b66\u201d\u7b49\u91cd\u70b9\u4e13\u9879\u7533\u62a5\u6307\u5357\uff0c\u7ee7\u7eed\u5bf9\u6e2f\u6fb3\u7279\u533a\u5f00\u653e<\/div>\n
\u79d1\u7814<\/div>\n
7. Cell\uff1a\u8bb0\u5fc6\u53ef\u201c\u9057\u4f20\u201d\uff0c\u795e\u7ecf\u6d3b\u52a8\u5f71\u54cd\u540e\u4ee3\u57fa\u56e0\u8868\u8fbe\u00a0<\/div>\n
8. Science\uff1a\u5f20\u5cf0\u56e2\u961f\u901a\u8fc7CRISPR\u76f8\u5173\u8f6c\u5ea7\u9176\u5b9e\u73b0DNA\u9ad8\u6548\u5b9a\u5411\u63d2\u5165\u00a0\u00a0<\/div>\n
9. Nature\uff1a\u57fa\u4e8e\u57fa\u56e0\u7f16\u8f91\uff0c\u795e\u7ecf\u79d1\u5b66\u5bb6\u5f00\u53d1\u4e86\u65b0\u7684\u81ea\u95ed\u75c7\u6a21\u578b\u00a0\u00a0<\/div>\n
10. mBio\uff1a\u7ec6\u83cc\u901a\u8fc7mRNA\u5408\u6210\u8868\u8fbe\u6297\u751f\u7d20\u80bd\u7684\u65b0\u57fa\u56e0\u00a0\u00a0<\/div>\n
11. Cell\uff1a\u53d1\u73b0\u4e0e\u63a5\u79cd\u540e\u514d\u75ab\u529b\u76f8\u5173\u7684\u9057\u4f20\u53d8\u5f02\u00a0<\/div>\n
12. Nature\uff1a\u591a\u7ec4\u5b66\u7814\u7a76IBD\u60a3\u8005\u7684\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u00a0\u00a0<\/div>\n
13. Nature Genetics\uff1a\u756a\u8304\u7684\u6cdb\u57fa\u56e0\u7ec4\u7814\u7a76<\/div>\n
\u5e94\u7528<\/div>\n
14.\u00a0FDA\u6388\u4e88Zygel\u6cbb\u7597\u8106\u6027X\u7efc\u5408\u5f81\u7684\u5feb\u901f\u901a\u9053\u8d44\u683c<\/div>\n
15. \u98de\u6714\u751f\u7269EGFR\u4f34\u968f\u8bca\u65ad\u4ea7\u54c1\u83b7\u5f97NMPA\u8ba4\u8bc1<\/div>\n
16. \u65b0\u751f\u513f\u91cd\u75c7\u76d1\u62a4\u7684\u5feb\u901f\u5168\u57fa\u56e0\u7ec4\u68c0\u6d4b<\/div>\n
17. NEJM\uff1a\u764c\u75c7\u5e72\u7ec6\u80de\u7684\u4e34\u5e8a\u6cbb\u7597\u7efc\u8ff0\u00a0<\/div>\n
\u4ea7\u4e1a<\/div>\n
18. \u6e56\u5317\u63a8\u8fdb\u767e\u4ebf\u5143\u4ea7\u4e1a\u53d1\u5c55\u5f15\u5bfc\u57fa\u91d1\u548c\u521b\u65b0\u6bcd\u57fa\u91d1\u00a0 \u00a0<\/div>\n
19. \u9752\u5c9b500\u4ebf\u5143\u79d1\u521b\u6bcd\u57fa\u91d1\u8fd0\u8425\u5c06\u542f\u52a8\u3002\u6b63\u62db\u6807\u5bfb\u627e\u8fd0\u8425\u673a\u6784\u00a0<\/div>\n
20. \u4e2d\u56fd\u751f\u7269\u4ea7\u4e1a\u53d1\u5c55\u6307\u6570CBIB\u6b63\u5f0f\u53d1\u5e03\u00a0\u00a0<\/div>\n
21. \u836f\u4f01Vertex\u6295\u516520\u4ebf\u7f8e\u5143\uff0c\u62d3\u5c55DMD\u548cDM1\u7684\u57fa\u56e0\u6cbb\u7597<\/div>\n
22. \u56fd\u9645\u8d22\u56e2\u6295\u51651.8\u4ebf\u7f8e\u5143\uff0c\u901a\u8fc7\u7eb3\u7c73\u5b54\u6d4b\u5e8f\u9274\u5b9a\u8d85\u8fc71000\u4e07\u79cd\u751f\u7269\u00a0 \u00a0<\/div>\n
23. Merck 7.7\u4ebf\u7f8e\u5143\u6536\u8d2dTilos\uff0c\u62d3\u5c55\u764c\u75c7\u53ca\u514d\u75ab\u76f8\u5173\u7ba1\u7ebf\u00a0 \u00a0<\/div>\n
24. \u4e34\u5e8a\u57fa\u56e0\u7ec4\u68c0\u6d4b\u516c\u53f8Variantyx\u878d\u8d44700\u4e07\u7f8e\u5143<\/div>\n
25. \u5b89\u5409\u5eb7\u5c14\u5b8c\u62103000\u4e07\u5143\u4eba\u6c11\u5e01A\u8f6e\u878d\u8d44\u00a0\u00a0<\/div>\n
26. \u7f8e\u56fd\u764c\u75c7\u57fa\u56e0\u7ec4\u6570\u636e\u516c\u53f8Personalis\u7533\u8bf7IPO<\/div>\n
27. \u73c0\u91d1\u57c3\u5c14\u9ed8\u6210\u7acb\u533b\u7597\u8bca\u65ad\u521b\u6295\u57fa\u91d1\u00a0\u00a0<\/div>\n
28. Paragon Genomics\u63a8\u51fa\u4e0e\u534e\u5927\u667a\u9020\u6d4b\u5e8f\u5e73\u53f0\u517c\u5bb9\u7684\u4ea7\u54c1\u00a0 \u00a0<\/div>\n
29. \u8d5b\u9ed8\u98de\u4e0e\u591a\u5bb6\u672c\u571f\u4f01\u4e1a\u7b7e\u7f72\u6218\u7565\u5408\u4f5c<\/div>\n
30. \u91d1\u57df\u533b\u5b66\u4e0e\u5317\u4eac\u534f\u548c\u533b\u5b66\u57fa\u91d1\u4f1a\u8054\u5408\u6210\u7acb\u6bcd\u5a74\u5065\u5eb7\u4e13\u9879\u57fa\u91d1<\/div>\n
\u4f1a\u8bae<\/div>\n
31. 2019\u5e74CSCO\u5b66\u672f\u5e74\u4f1a\uff0c9\u670818\u65e5-22\u65e5\uff0c\u53a6\u95e8\u00a0 \u00a0<\/div>\n
32. 2019\u9996\u5c4a\u7f55\u89c1\u75c5\u5408\u4f5c\u4ea4\u6d41\u4f1a\uff0c7\u67086\u65e5-7\u65e5\uff0c\u5317\u4eac\u00a0\u00a0<\/div>\n
33. \u7b2c\u4e09\u5c4a\u57fa\u56e0\u5065\u5eb7\u5927\u4f1a\uff0c9\u670820\u65e5-22\u65e5\uff0c\u6210\u90fd<\/div>\n
34. \u4e2d\u56fd\u5352\u4e2d\u5b66\u4f1a\u7b2c\u4e94\u5c4a\u5b66\u672f\u5e74\u4f1a\u66a8\u5929\u575b\u56fd\u9645\u8111\u8840\u7ba1\u75c5\u4f1a\u8bae\uff0c6\u670828\u65e5-30\u65e5\uff0c\u5317\u4eac\u00a0\u00a0<\/div>\n
35. \u7b2c\u5341\u4e5d\u5c4a\u4e2d\u534e\u9884\u9632\u533b\u5b66\u4f1a\u5fae\u751f\u6001\u5b66\u5b66\u672f\u4f1a\uff0c9\u67086\u65e5-8\u65e5\uff0c\u6d77\u5357\u00a0<\/div>\n
36. \u4e0b\u4e00\u4ee3\u80fd\u6e90\u5e94\u7528\u6750\u6599\uff0c11\u670817\u65e5-19\u65e5\uff0c\u53a6\u95e8<\/div>\n
\u00a0<\/div>\n
\u653f\u7b56<\/div>\n
1. \u652f\u6301\u793e\u4f1a\u529e\u533b\uff0c9\u6708\u5e95\u524d\u51fa\u53f0\u4e92\u8054\u7f51\u8bca\u7597\u6536\u8d39\u653f\u7b56<\/div>\n
6\u670812\u65e5\uff0c\u56fd\u5bb6\u536b\u5065\u59d4\u53d1\u5e03\u300a\u5370\u53d1\u4fc3\u8fdb\u793e\u4f1a\u529e\u533b\u6301\u7eed\u5065\u5eb7\u89c4\u8303\u53d1\u5c55\u610f\u89c1\u7684\u901a\u77e5\u300b\uff0c\u63d0\u51fa\u652f\u6301\u793e\u4f1a\u529e\u533b\u53d1\u5c55\u201c\u4e92\u8054\u7f51+\u533b\u7597\u5065\u5eb7\u201d\u3002\u793e\u4f1a\u529e\u533b\u6b63\u5f0f\u8fd0\u84253\u4e2a\u6708\u540e\u5373\u53ef\u63d0\u51fa\u5b9a\u70b9\u7533\u8bf7\uff0c\u5b9a\u70b9\u8bc4\u4f30\u5b8c\u6210\u65f6\u9650\u4e0d\u5f97\u8d85\u8fc73\u4e2a\u6708\uff1b2019\u5e749\u6708\u5e95\u524d\uff0c\u5236\u5b9a\u51fa\u53f0\u4e92\u8054\u7f51\u8bca\u7597\u6536\u8d39\u653f\u7b56\u548c\u533b\u4fdd\u652f\u4ed8\u653f\u7b56\u7b49\uff08\u56fd\u5bb6\u536b\u5065\u59d4\uff09\u3002<\/div>\n
\u00a0<\/div>\n
2.\u00a06\u670815\u65e5\u8d773700\u5bb6\u533b\u9662\u53d6\u6d88\u533b\u8017\u52a0\u6210<\/div>\n
6\u670815\u65e5\u96f6\u65f6\uff0c\u5317\u4eac\u533b\u8017\u8054\u52a8\u7efc\u5408\u6539\u9769\u5c06\u6b63\u5f0f\u5b9e\u65bd\uff0c\u5c06\u53d6\u6d88\u533b\u7597\u673a\u6784\u533b\u7528\u8017\u67505%\u621610%\u7684\u52a0\u4ef7\u653f\u7b56\uff0c\u6309\u533b\u7528\u8017\u6750\u91c7\u8d2d\u8fdb\u4ef7\u6536\u8d39\uff1b\u964d\u4f4e\u4eea\u5668\u8bbe\u5907\u5f00\u5c55\u7684\u68c0\u9a8c\u9879\u76ee\u4ef7\u683c\uff1b\u63d0\u5347\u4f53\u73b0\u533b\u52a1\u4eba\u5458\u52b3\u52a8\u4ef7\u503c\u7684\u9879\u76ee\u4ef7\u683c\uff08\u5317\u4eac\u65e5\u62a5\uff09\u3002<\/div>\n
\u00a0<\/div>\n
3. \u56fd\u5bb6\u836f\u5178\u59d4\u516c\u793a\u300a\u4eba\u7528\u57fa\u56e0\u6cbb\u7597\u5236\u54c1\u603b\u8bba\u8349\u6848\u300b<\/div>\n
6\u670810\u65e5\uff0c\u56fd\u5bb6\u836f\u5178\u59d4\u5458\u4f1a\u53d1\u5e03\u300a\u5173\u4e8e\u4eba\u7528\u57fa\u56e0\u6cbb\u7597\u5236\u54c1\u603b\u8bba\u8349\u6848\u7684\u516c\u793a\u300b\u3002\u901a\u77e5\u8868\u793a2017\u5e74\u7acb\u9879\u5f00\u5c55\u76f8\u5173\u7814\u7a76\u5de5\u4f5c\u62df\u5efa\u7acb\u4eba\u7528\u57fa\u56e0\u6cbb\u7597\u5236\u54c1\u603b\u8bba\uff0c\u73b0\u5df2\u5b8c\u6210\u76f8\u5173\u8d77\u8349\u590d\u6838\u5de5\u4f5c\u3002<\/div>\n
\uff08http:\/\/www.chp.org.cn\/view\/ff8080816a583947016b400a6458575e?a=BZSWZP\uff09<\/div>\n
\u00a0<\/div>\n
4.\u00a017\u79cd\u6297\u764c\u836f\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\u8c08\u5224\uff0c\u5e73\u5747\u964d\u4ef756.7%<\/div>\n
6\u670814\u65e5\uff0c\u56fd\u5bb6\u536b\u5065\u59d4\u4f53\u6539\u53f8\u5de1\u89c6\u5458\u6731\u6d2a\u5f6a\u8868\u793a\uff0c\u73b0\u5df2\u5b9e\u884c\u8fdb\u53e3\u6297\u764c\u836f\u96f6\u5173\u7a0e\uff0c\u5f00\u5c5517\u79cd\u6297\u764c\u836f\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\u8c08\u5224\uff0c\u5e73\u5747\u964d\u4ef756.7%\u3002\u533b\u4fdd\u652f\u4ed8\u65b9\u5f0f\u7684\u6539\u9769\u662f\u533b\u7597\u6539\u9769\u7684\u91cd\u8981\u65b9\u5f0f\uff0c\u73b0\u5728294\u4e2a\u57ce\u5e02\u5b9e\u884c\u6309\u75c5\u79cd\u4ed8\u8d39\u7684\u75c5\u79cd\u6570\u8d85\u8fc7100\u4e2a\uff08\u65b0\u6d6a\u8d22\u7ecf\uff09\u3002<\/div>\n
\u00a0<\/div>\n
5. \u7f8e\u56fdNIH\u5ba3\u5e03\u5c06\u8fdb\u884c\u80be\u810f\u75be\u75c5\u3001\u6291\u90c1\u75c7\u7b49\u57fa\u56e0\u7ec4\u533b\u5b66\u7814\u7a76<\/div>\n
\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u4eca\u5929\u5ba3\u5e03\u4e86\u4e24\u9879\u4e34\u5e8a\u7814\u7a76\u8ba1\u5212\uff0c\u8be5\u7814\u7a76\u5c06\u8c03\u67e5\u57fa\u56e0\u7ec4\u533b\u5b66\u5728\u6cbb\u7597\u5305\u62ec\u80be\u810f\u75be\u75c5\u548c\u6291\u90c1\u75c7\u5728\u5185\u7684\u4e00\u7cfb\u5217\u75be\u75c5\u65b9\u9762\u7684\u76ca\u5904\uff08NIH\u5b98\u7f51\uff09\u3002<\/div>\n
\u00a0<\/div>\n
6. \u79d1\u6280\u90e8\u53d1\u5e03\u201c\u5408\u6210\u751f\u7269\u5b66\u201d\u7b49\u91cd\u70b9\u4e13\u9879\u7533\u62a5\u6307\u5357\uff0c\u7ee7\u7eed\u5bf9\u6e2f\u6fb3\u7279\u533a\u5f00\u653e<\/div>\n
6\u670814\u65e5\uff0c\u79d1\u6280\u90e8\u53d1\u5e03\u300a\u5173\u4e8e\u53d1\u5e03\u56fd\u5bb6\u91cd\u70b9\u7814\u53d1\u8ba1\u5212\u201c\u5408\u6210\u751f\u7269\u5b66\u201d\u7b49\u91cd\u70b9\u4e13\u98792019\u5e74\u5ea6\u9879\u76ee\u7533\u62a5\u6307\u5357\u7684\u901a\u77e5\u300b\uff0c\u9f13\u52b1\u6e2f\u6fb3\u9ad8\u6821\u8054\u5408\u5185\u5730\u5355\u4f4d\u5171\u540c\u7533\u62a5\u3002\u9879\u76ee\u7533\u62a5\u5355\u4f4d\u7f51\u4e0a\u586b\u62a5\u9884\u7533\u62a5\u4e66\u7684\u53d7\u7406\u65f6\u95f4\u4e3a\uff1a2019\u5e746\u670818\u65e58:00\u81f32019\u5e748\u67087\u65e516:00\uff08\u79d1\u6280\u90e8\uff09\u3002<\/div>\n
\u00a0<\/div>\n
\u79d1\u7814<\/div>\n
7. Cell\uff1a\u8bb0\u5fc6\u53ef\u201c\u9057\u4f20\u201d\uff0c\u795e\u7ecf\u6d3b\u52a8\u5f71\u54cd\u540e\u4ee3\u57fa\u56e0\u8868\u8fbe<\/div>\n
6\u67088\u65e5\uff0c\u300aCell\u300b\u540c\u65e5\u8fde\u7eed\u53d1\u8868\u4e24\u7bc7\u91cd\u78c5\u6587\u7ae0\uff0c\u7814\u7a76\u4eba\u5458\u5728\u5bf9\u7ebf\u866b\u7684\u7814\u7a76\u4e2d\u53d1\u73b0\uff0c\u8bb0\u5fc6\u53ef\u4ee5\u88ab\u9057\u4f20\uff0c\u751a\u81f3\u6301\u7eed3-4\u4ee3\u3002\u5373\uff0c\u7ebf\u866b\u7684\u795e\u7ecf\u7cfb\u7edf\u53ef\u4ee5\u901a\u8fc7\u795e\u7ecf\u5143\uff0c\u5411\u751f\u6b96\u7ec6\u80de\u4f20\u9012\u4fe1\u606f\uff0c\u5f71\u54cd\u540e\u4ee3\u57fa\u56e0\u8868\u8fbe\u3002<\/div>\n
( https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(19)30448-9 ;<\/div>\n
https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(19)30552-5 )<\/div>\n
\u00a0<\/div>\n
8. Science\uff1a\u5f20\u5cf0\u56e2\u961f\u901a\u8fc7CRISPR\u76f8\u5173\u8f6c\u5ea7\u9176\u5b9e\u73b0DNA\u9ad8\u6548\u5b9a\u5411\u63d2\u5165<\/div>\n
6\u67086\u65e5\uff0cBroad\u7684\u5f20\u5cf0\u56e2\u961f\u548cNIH\u56e2\u961f\uff0c\u57fa\u4e8e\u84dd\u7ec6\u83ccScytonema hofmanni\u7684CRISPR\u76f8\u5173\u8f6c\u5ea7\u9176\uff08CAST\uff09\uff0c\u5f00\u53d1\u4e86\u65b0\u7684\u57fa\u56e0\u7f16\u8f91\u7cfb\u7edfshCAST\uff0c\u5b9e\u73b0\u4e86\u65b0\u578b\u9ad8\u6548\u7684DNA\u5b9a\u5411\u63d2\u5165\u3002 ShCAST\u5c06DNA\u6574\u5408\u5230\u5927\u80a0\u6746\u83cc\u57fa\u56e0\u7ec4\u4e2d\u7684\u7279\u5b9a\u4f4d\u70b9\uff0c\u7f16\u8f91\u6548\u7387\u9ad8\u8fbe80\uff05\uff0c\u65e0\u9700\u6b63\u9009\u62e9\u3002<\/div>\n
\uff08https:\/\/science.sciencemag.org\/content\/early\/2019\/06\/05\/science.aax9181.full\uff09<\/div>\n
\u00a0<\/div>\n
9. Nature\uff1a\u57fa\u4e8e\u57fa\u56e0\u7f16\u8f91\uff0c\u795e\u7ecf\u79d1\u5b66\u5bb6\u5f00\u53d1\u4e86\u65b0\u7684\u81ea\u95ed\u75c7\u6a21\u578b<\/div>\n
6\u670812\u65e5\uff0c\u57fa\u4e8eCRISPR-Cas9\u57fa\u56e0\u7f16\u8f91\u6280\u672f\uff0cMIT\u548c\u4e2d\u56fd\u56e2\u961f\u901a\u8fc7\u98df\u87f9\u7334\u7315\u7334\uff08Macaca fascicularis\uff09\u548c\u5b83\u4eec\u7684F1\u540e\u4ee3\u7684SHANK3\u57fa\u56e0\u80da\u7cfb\u7a81\u53d8\uff0c\u6765\u5efa\u7acb\u65b0\u7684\u81ea\u95ed\u75c7\u6a21\u578b\u3002\u8fd9\u4e9b\u7315\u7334\u8868\u73b0\u51fa\u7684\u90e8\u5206\u884c\u4e3a\u7279\u5f81\u4e0e\u60a3\u6709\u8fd9\u4e9b\u75be\u75c5\u7684\u4eba\u7c7b\u76f8\u4f3c\u3002\u53c2\u4e0e\u8fd9\u9879\u7814\u7a76\u7684\u4e2d\u56fd\u56e2\u961f\u5305\u62ec\u7531\u6df1\u5733\u5e02\u5148\u8fdb\u6280\u672f\u7814\u7a76\u9662\u7684Huihui Zhou\uff0c\u4e2d\u5c71\u5927\u5b66\u7684Andy Peng Xiang\u548c\u534e\u5357\u519c\u4e1a\u5927\u5b66\u7684Shihua Yang\u7b49\u3002<\/div>\n
\uff08https:\/\/www.nature.com\/articles\/s41586-019-1278-0\uff09<\/div>\n
\u00a0<\/div>\n
10 mBio\uff1a\u7ec6\u83cc\u901a\u8fc7mRNA\u5408\u6210\u8868\u8fbe\u6297\u751f\u7d20\u80bd\u7684\u65b0\u57fa\u56e0<\/div>\n
\u8fd1\u65e5\uff0c\u7531Uppsala University\u751f\u7269\u5316\u5b66\u548c\u5fae\u751f\u7269\u5b66\u7cfb\u6559\u6388\u3001\u533b\u5b66\u7ec6\u83cc\u5b66\u5bb6Dan I. Andersson\u535a\u58eb\u9886\u5bfc\u7684\u56e2\u961f\uff0c\u5728\u5927\u80a0\u6746\u83cc\u53d1\u73b0\u5bf9\u6c28\u57fa\u7cd6\u7519\u7c7b\u6297\u751f\u7d20\u9ad8\u5ea6\u6297\u6027\u7684\u77ed\u80bd\uff0822\u81f325\u4e2a\u6c28\u57fa\u9178\u957f\uff09\u3002<\/div>\n
(\u00a0https:\/\/mbio.asm.org\/content\/10\/3\/e00837-19\u00a0)<\/div>\n
\u00a0<\/div>\n
11. Cell\uff1a\u53d1\u73b0\u4e0e\u63a5\u79cd\u540e\u514d\u75ab\u529b\u76f8\u5173\u7684\u9057\u4f20\u53d8\u5f02<\/div>\n
6\u670811\u65e5\uff0c\u79d1\u5b66\u5bb6\u5bf9\u4e09\u79cd\u513f\u7ae5\u75ab\u82d7\u8fdb\u884c\u4e86GWAS\u7814\u7a76\uff1a\u835a\u819c\u7ec4C\u8111\u819c\u708e\u7403\u83cc\uff08MenC\uff09\uff0cb\u578b\u6d41\u611f\u55dc\u8840\u6746\u83cc\u548c\u7834\u4f24\u98ce\u7c7b\u6bd2\u7d20\uff08TT\uff09\u75ab\u82d7\u3002\u53d1\u73b0\u4e86\u76f8\u5173SNP\u4e0e\u514d\u75ab\u6301\u7eed\u6027\u7684\u5173\u8054\u3002<\/div>\n
\u00a0( https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(19)30682-5)<\/div>\n
\u00a0<\/div>\n
12.\u00a0Nature\uff1a\u591a\u7ec4\u5b66\u7814\u7a76IBD\u60a3\u8005\u7684\u80a0\u9053\u5fae\u751f\u7269\u7ec4<\/div>\n
5\u670829\u65e5\uff0cBroad Institute\u7b49\u56e2\u961f\u5171\u540c\u53d1\u8868\u4e86\u57fa\u4e8eIBD\u5bf9\u4e8e\u80a0\u9053\u5fae\u751f\u7269\u7684\u5f71\u54cd\uff0c\u4ee5\u53ca\u5fae\u751f\u7269\u7ec4\u7684\u91cf\u5316\u65b9\u6cd5\uff0c\u5305\u62ec\u5b8f\u57fa\u56e0\u7ec4\u3001\u4ee3\u8c22\u7ec4\u5b66\u3001\u5b8f\u8f6c\u5f55\u7ec4\uff08metatranscriptomic\uff09\u548c\u5176\u4ed6\u65b9\u6cd5\u7b49\uff0c \u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u4e0e\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u76f8\u6bd4\uff0cIBD-Crohn\u75c5\u5bf9\u5fae\u751f\u7269\u7ec4\u7684\u6d3b\u6027\u548c\u7ec4\u6210\u6709\u4e0d\u540c\u7684\u5f71\u54cd\u3002<\/div>\n
\uff08 https:\/\/www.nature.com\/articles\/s41586-019-1237-9\u00a0\uff09<\/div>\n
\u00a0<\/div>\n
13.\u00a0Nature Genetics\uff1a\u756a\u8304\u7684\u6cdb\u57fa\u56e0\u7ec4\u7814\u7a76<\/div>\n
5\u670813\u65e5\uff0c\u6cdb\u57fa\u56e0\u7ec4\u7814\u7a76\u5df2\u7ecf\u5728\u6c34\u7a3b\u3001\u5c0f\u9ea6\u3001\u9e1f\u7c7b\u7b49\u7269\u79cd\u4e2d\u5c55\u5f00\u3002\u8fd1\u671f\u300aNature Genetics\u300b\u53d1\u8868\u4e8e\u4e86\u756a\u8304\u7684\u6cdb\u57fa\u56e0\u7ec4\u7814\u7a76\u7ed3\u679c\uff0c\u8bba\u6587\u7684\u901a\u8baf\u4f5c\u8005\u662f\u7f8e\u56fd\u5eb7\u5948\u5c14\u5927\u5b66\u7684James J. Giovannoni\u6559\u6388\u548c\u8d39\u7ae0\u541b\u6559\u6388\u56e2\u961f\u3002<\/div>\n
(\u00a0https:\/\/www.nature.com\/articles\/s41588-019-0410-2\u00a0\uff09<\/div>\n
\u00a0<\/div>\n
\u5e94\u7528<\/div>\n
\u00a0<\/div>\n
14.\u00a0FDA\u6388\u4e88Zygel\u6cbb\u7597\u8106\u6027X\u7efc\u5408\u5f81\u7684\u5feb\u901f\u901a\u9053\u8d44\u683c<\/div>\n
\u8fd1\u65e5\uff0cFDA\u6388\u4e88Zynerba\u5236\u836f\u516c\u53f8\u7684Zygel\u2122\uff08ZYN002\u5927\u9ebb\u4e8c\u915a\u51dd\u80f6\uff09\u6cbb\u7597\u8106\u6027X\u7efc\u5408\u5f81\uff08Fragile X Syndrome\uff0cFXS\uff09\u76f8\u5173\u884c\u4e3a\u75c7\u72b6\u7684\u5feb\u901f\u901a\u9053\u8d44\u683c\u8ba4\u5b9a\uff08\u7f55\u89c1\u75c5\u4fe1\u606f\u7f51\uff09\u3002<\/div>\n
\u00a0<\/div>\n
15.\u98de\u6714\u751f\u7269EGFR\u4f34\u968f\u8bca\u65ad\u4ea7\u54c1\u83b7\u5f97NMPA\u8ba4\u8bc1<\/div>\n
5\u670831\u65e5\uff0c\u98de\u6714\u751f\u7269\u7814\u53d1\u751f\u4ea7\u7684\u4eba\u7c7bEGFR\u57fa\u56e0\u7a81\u53d8\u68c0\u6d4b\u8bd5\u5242\u76d2\uff08\u591a\u91cd\u8367\u5149PCR\u6cd5\uff09\u6b63\u5f0f\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u4e09\u7c7b\u533b\u7597\u5668\u68b0\u6ce8\u518c\u8bc1\u3002\u9884\u671f\u7528\u9014\uff1a\u7528\u4e8e\u5b9a\u6027\u68c0\u6d4b\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u77f3\u8721\u5305\u57cb\u7ec4\u7ec7\u6837\u672cDNA\u4e2d\u4eba\u7c7bEGFR\u57fa\u56e029\u79cd\u4f53\u7ec6\u80de\u7a81\u53d8\u3002\u5176\u4e2d\uff0c19\u5916\u663e\u5b50\u7f3a\u5931\u3001L858R\u70b9\u7a81\u53d8\u7528\u4e8e\u90e8\u5206EGFR-TKI\u7684\u4f34\u968f\u8bca\u65ad\u3002<\/div>\n
\u00a0<\/div>\n
16.\u00a0\u65b0\u751f\u513f\u91cd\u75c7\u76d1\u62a4\u7684\u5feb\u901f\u5168\u57fa\u56e0\u7ec4\u68c0\u6d4b<\/div>\n
\u4e34\u5e8a\u5168\u57fa\u56e0\u7ec4\u68c0\u6d4b\uff08cWGS\uff09\u5728\u4e0eWES\u3001Panel\u7684\u6027\u4ef7\u6bd4\u53cd\u590d\u8ba8\u8bba\u4e2d\uff0c\u9010\u6e10\u843d\u5b9e\u5230\u5177\u4f53\u7684\u573a\u666f\uff0c\u4f8b\u5982\u65b0\u751f\u513f\u53ca\u513f\u79d1\u91cd\u75c7\u76d1\u62a4\u75c5\u623f\uff08NICU\/PICU\uff09\u5bf9\u75c5\u56e0\u4e0d\u660e\u7684\u5148\u5929\u6027\u7578\u5f62\u6216\u795e\u7ecf\u53d1\u80b2\u969c\u788d\u7684\u513f\u7ae5\u53ca\u7591\u4f3c\u60a3\u6709\u9057\u4f20\u75c5\u7684\u91cd\u75c5\u60a3\u513f\u3002Illumina\u5728\u548cRady’s\u7b49\u4e94\u5bb6\u52a0\u5dde\u7684\u533b\u7597\u673a\u6784\u5f00\u5c55\u201c\u718a\u5b9d\u5b9d\u8ba1\u5212\u201d\u540e\uff0c\u8fd1\u671f\u643a\u624b\u590d\u65e6\u513f\u79d1\u533b\u9662\uff0c\u8ba1\u5212NICU\u5165\u7ec4200\u4f8b\u60a3\u8005\u8fdb\u884ccWGS\u68c0\u6d4b\u3002<\/div>\n
\u00a0<\/div>\n
17. NEJM\u7efc\u8ff0\uff1a\u764c\u75c7\u5e72\u7ec6\u80de\u7684\u4e34\u5e8a\u6cbb\u7597<\/div>\n
\u7ee75\u6708\uff0c\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\uff08NEJM\uff09\u53d1\u8868\u5e72\u7ec6\u80de\u5728\u75be\u75c5\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\u7684\u7efc\u8ff0\u540e\uff0c6\u67086\u65e5\uff0cNEJM\u53d1\u8868\u4e86\u764c\u75c7\u5e72\u7ec6\u80de\u76f8\u5173\u7efc\u8ff0\u3002\uff08https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMra1804280\uff09<\/div>\n
\u00a0<\/div>\n
\u4ea7\u4e1a<\/div>\n
18. \u6e56\u5317\u63a8\u8fdb\u767e\u4ebf\u5143\u4ea7\u4e1a\u53d1\u5c55\u5f15\u5bfc\u57fa\u91d1\u548c\u521b\u65b0\u6bcd\u57fa\u91d1<\/div>\n
6\u670811\u65e5\uff0c\u957f\u6c5f\u4ea7\u4e1a\u57fa\u91d1\u4e0e34\u4e2a\u5e02\u53bf\u7b7e\u7f72\u53bf\u57df\u4ea7\u4e1a\u57fa\u91d1\u5408\u4f5c\u6846\u67b6\u534f\u8bae\u3002\u63a8\u8fdb\u603b\u89c4\u6a21100\u4ebf\u5143\u7684\u53bf\u57df\u7ecf\u6d4e\u53d1\u5c55\u5f15\u5bfc\u57fa\u91d1\u843d\u5730\uff08\u5305\u62ec\u957f\u6c5f\u7ecf\u6d4e\u5e26\u4ea7\u4e1a\u5f15\u5bfc\u57fa\u91d1\u5355\u521780\u4ebf\u5143\uff0c\u7701\u7ea7\u80a1\u6743\u6295\u8d44\u5f15\u5bfc\u57fa\u91d1\u5355\u521718\u4ebf\u5143\uff0c\u7701\u521b\u4e1a\u6295\u8d44\u5f15\u5bfc\u57fa\u91d1\u5355\u52172\u4ebf\u5143\uff09\u3002<\/div>\n
\u00a0<\/div>\n
19.\u00a0\u9752\u5c9b500\u4ebf\u5143\u79d1\u521b\u6bcd\u57fa\u91d1\u8fd0\u8425\u5c06\u542f\u52a8\u3002\u6b63\u62db\u6807\u5bfb\u627e\u8fd0\u8425\u673a\u6784<\/div>\n
5\u67089\u65e5\u6d88\u606f\uff0c\u9752\u5c9b\u79d1\u6280\u521b\u65b0\u6bcd\u57fa\u91d1\u805a\u7126\u786c\u79d1\u6280\uff0c\u5bf9\u6807\u79d1\u521b\u677f\uff0c\u91cd\u70b9\u652f\u6301\u539f\u59cb\u521b\u65b0\u3001\u6210\u679c\u8f6c\u5316\u53ca\u9ad8\u7aef\u79d1\u6280\u4ea7\u4e1a\u5316\u9879\u76ee\u57f9\u80b2\u3002\u6bcd\u57fa\u91d1\u603b\u89c4\u6a21500\u4ebf\u5143\uff0c\u9996\u671f120\u4ebf\u5143\uff0c\u653f\u5e9c\u6027\u8d44\u91d1\u51fa\u8d44\u6bd4\u4f8b\u6700\u9ad8\u53ef\u8fbe50%\u3002<\/div>\n
\u00a0<\/div>\n
20.\u00a0\u4e2d\u56fd\u751f\u7269\u4ea7\u4e1a\u53d1\u5c55\u6307\u6570CBIB\u6b63\u5f0f\u53d1\u5e03<\/div>\n
6\u670810\u65e5-12\u65e5\uff0c\u5728\u7b2c\u5341\u4e8c\u5c4a\u751f\u7269\u4ea7\u4e1a\u5927\u4f1a\uff08\u4e2d\u56fd\u5e7f\u5dde\uff09\u3001\u7531\u706b\u77f3\u7814\u7a76\u9662\u548c\u4e2d\u56fd\u751f\u7269\u5de5\u7a0b\u5b66\u4f1a\u5171\u540c\u7814\u53d1\u7684\u4e2d\u56fd\u751f\u7269\u4ea7\u4e1a\u53d1\u5c55\u6307\u6570CBIB\u6b63\u5f0f\u53d1\u5e03\u3002<\/div>\n
\u00a0<\/div>\n
21.\u00a0\u836f\u4f01Vertex\u6295\u516520\u4ebf\u7f8e\u5143\uff0c\u62d3\u5c55DMD\u548cDM1\u7684\u57fa\u56e0\u6cbb\u7597<\/div>\n
6\u670810\u65e5\uff0cVertex Pharmaceuticals\u5f00\u5c5520\u4ebf\u7f8e\u5143\u4ea4\u6613\uff0c\u4f7f\u8be5\u516c\u53f8\u80fd\u591f\u5f00\u53d1\u6cbb\u7597DMD\u548cDM1\u7684\u65b0\u7597\u6cd5\u3002Vertex\u5ba3\u5e03\u8ba1\u5212\u4ee5\u7ea610\u4ebf\u7f8e\u5143\u7684\u4ef7\u683c\u6536\u8d2dExonics Therapeutics\uff0c\u5e76\u82b1\u8d39\u989d\u5916\u9ad8\u8fbe11.75\u4ebf\u7f8e\u5143\u7684\u8d44\u91d1\uff0c\u4ee5\u6269\u5927\u4e0eCRISPR Therapeutics\u5408\u4f5c\u76843\u5e74\u534a\uff0c\u53ef\u80fd\u8d85\u8fc725\u4ebf\u7f8e\u5143\u7684\u5408\u4f5c\u3002<\/div>\n
\u00a0<\/div>\n
22.\u00a0\u56fd\u9645\u8d22\u56e2\u6295\u51651.8\u4ebf\u7f8e\u5143\uff0c\u901a\u8fc7\u7eb3\u7c73\u5b54\u6d4b\u5e8f\u9274\u5b9a\u8d85\u8fc71000\u4e07\u79cd\u751f\u7269<\/div>\n
6\u67087\u65e5\uff0c\u6765\u81eaScience\u7684\u62a5\u9053\uff0c\u6d4b\u5e8f\u7684\u4ef7\u683c\u666e\u60e0\u8d8b\u52bf\uff0c\u5e2e\u52a9\u751f\u7269\u5b66\u5bb6\u63d0\u5347\u9274\u5b9a\u7269\u79cd\u7684\u901f\u5ea6\u3002\u67d0\u56fd\u9645\u8d22\u56e2\u6295\u51651.8\u4ebf\u7f8e\u5143\uff0c\u8ba1\u5212\u5728\u5168\u7403\u8303\u56f4\u9274\u5b9a\u8d85\u8fc71000\u4e07\u79cd\u65b0\u7684\u591a\u7ec6\u80de\u751f\u7269\u3002<\/div>\n
\u00a0<\/div>\n
23.\u00a0Merck 7.7\u4ebf\u7f8e\u5143\u6536\u8d2dTilos\uff0c\u62d3\u5c55\u764c\u75c7\u53ca\u514d\u75ab\u76f8\u5173\u7ba1\u7ebf<\/div>\n
6\u670811\u65e5\u6d88\u606f\uff0cMerck & Co.\u8ba1\u5212\u65a5\u8d44\u9ad8\u8fbe7.73\u4ebf\u7f8e\u5143\u6536\u8d2dTilos Therapeutics\u3002Tilos\u4e13\u6ce8\u4e8e\u5f00\u53d1\u6297\u4f53\uff0c\u65e8\u5728\u9488\u5bf9\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b2\uff08TGF\u03b2\uff09\u7684\u6f5c\u4f0f\u76f8\u5173\u80bd\uff08LAP\uff09\uff0c\u8fd9\u662f\u4e00\u79cd\u88ab\u8ba4\u4e3a\u5728\u764c\u75c7\u548c\u7ea4\u7ef4\u5316\u75be\u75c5\u7684\u53d1\u5c55\u4e2d\u8d77\u91cd\u8981\u4f5c\u7528\u7684\u6709\u6548\u7ec6\u80de\u56e0\u5b50\u3002<\/div>\n
\u00a0<\/div>\n
24.\u00a0\u4e34\u5e8a\u57fa\u56e0\u7ec4\u68c0\u6d4b\u516c\u53f8Variantyx\u878d\u8d44700\u4e07\u7f8e\u5143<\/div>\n
6\u67086\u65e5\u6d88\u606f\uff0c\u4e34\u5e8a\u57fa\u56e0\u7ec4\u68c0\u6d4b\u516c\u53f8Variantyx\u5df2\u4ece\u4ee5\u8272\u5217\u516c\u53f8Pitango Venture Capital\u83b7\u5f97700\u4e07\u7f8e\u5143\u7684\u6295\u8d44\u3002 Variantyx\u662f2014\u5e74\u6765\u81ea\u7279\u62c9\u7ef4\u592b\u5927\u5b66\u7684\u5206\u652f\u673a\u6784\uff0c\u603b\u90e8\u4f4d\u4e8e\u9a6c\u8428\u8bf8\u585e\u5dde\u5f17\u96f7\u660e\u6c49\uff0c\u4e3a\u7b5b\u67e5\u548c\u7f55\u89c1\u75be\u75c5\u8bca\u65ad\u63d0\u4f9b\u4e34\u5e8a\u57fa\u56e0\u7ec4\u68c0\u6d4b\u3002<\/div>\n
\u00a0<\/div>\n
25.\u00a0\u5b89\u5409\u5eb7\u5c14\u5b8c\u62103000\u4e07\u5143\u4eba\u6c11\u5e01A\u8f6e\u878d\u8d44<\/div>\n
6\u670814\u65e5\uff0c\u5b89\u5409\u5eb7\u5c14\uff08\u6df1\u5733\uff09\u79d1\u6280\u6709\u9650\u516c\u53f8\u6b63\u5f0f\u5ba3\u5e03\u5b8c\u6210A\u8f6e3000\u4e07\u5143\u4eba\u6c11\u5e01\u878d\u8d44\u3002\u672c\u8f6e\u878d\u8d44\u7531\u5408\u521b\u8d44\u672c\u9886\u6295\uff0c\u539f\u6295\u8d44\u65b9\u6301\u7eed\u589e\u6301\u3002\u5b89\u5409\u5eb7\u5c14\u4e8e2017\u5e742\u6708\u6210\u7acb\uff0c\u81f4\u529b\u4e8e\u9057\u4f20\u75be\u75c5\u7cbe\u51c6\u8bca\u65ad\u548c\u7b5b\u67e5\u4e1a\u52a1\u3002<\/div>\n
\u00a0<\/div>\n
26.\u00a0\u7f8e\u56fd\u764c\u75c7\u57fa\u56e0\u7ec4\u6570\u636e\u516c\u53f8Personalis\u7533\u8bf7IPO<\/div>\n
6\u67087\u65e5\u6d88\u606f\uff0c\u636e\u62a5\u9053\u4e3a\u751f\u7269\u5236\u836f\u516c\u53f8\u63d0\u4f9b\u764c\u75c7\u57fa\u56e0\u7ec4\u6570\u636e\u7684Personalis\u5df2\u7533\u8bf7\u5728\u7eb3\u65af\u8fbe\u514b\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801PSNL\u3002 \u7533\u8bf7\u6587\u4ef6\u4e2d\u5217\u51fa\u7684\u7b79\u8d44\u91d1\u989d\u9884\u4f30\u4e3a1.15\u4ebf\u7f8e\u5143\u3002<\/div>\n
\u00a0<\/div>\n
27.\u00a0\u73c0\u91d1\u57c3\u5c14\u9ed8\u6210\u7acb\u533b\u7597\u8bca\u65ad\u521b\u6295\u57fa\u91d1<\/div>\n
6\u670812\u65e5\u6d88\u606f\uff0c\u73c0\u91d1\u57c3\u5c14\u9ed8\uff08PerkinElmer Inc.\uff0c NYSE\uff1a PKI\uff09\u5bf9\u5916\u5ba3\u5e03\uff0c\u6210\u7acb\u9996\u4e2a\u4e13\u6ce8\u4e8e\u4e2d\u56fd\u4f53\u5916\u8bca\u65ad\uff08IVD\uff09\u884c\u4e1a\u7684\u5e02\u573a\u5316\u4ea7\u4e1a\u57fa\u91d1\u2014\u2014\u73c0\u91d1\u57c3\u5c14\u9ed8\u521b\u6295\uff08PKI Ventures\uff09\u3002<\/div>\n
\u00a0<\/div>\n
28.\u00a0Paragon Genomics\u63a8\u51fa\u4e0e\u534e\u5927\u667a\u9020\u6d4b\u5e8f\u5e73\u53f0\u517c\u5bb9\u7684\u4ea7\u54c1<\/div>\n
6\u670813\u65e5\uff0cParagon Genomics\u5ba3\u5e03\u9996\u6279\u4e0e\u534e\u5927\u667a\u9020\u6d4b\u5e8f\u5e73\u53f0\u517c\u5bb9\u7684\u4ea7\u54c1 CleanPlex\u00ae \u6b63\u5f0f\u63a8\u51fa\uff0c\u5e76\u5c06\u4e8e6\u670815-6\u670818\u65e5\u4e3e\u529e\u7684\u6b27\u6d32\u4eba\u7c7b\u9057\u4f20\u5b66\u5927\u4f1a(ESHG2019)\u4e0a\u6b63\u5f0f\u53d1\u5e03\u3002<\/div>\n
\u00a0<\/div>\n
29.\u00a0\u8d5b\u9ed8\u98de\u4e0e\u591a\u5bb6\u672c\u571f\u4f01\u4e1a\u7b7e\u7f72\u6218\u7565\u5408\u4f5c<\/div>\n
\u8fd1\u65e5\uff0c\u8d5b\u9ed8\u98de\u5206\u522b\u4e0e\u5b89\u667a\u56e0\u751f\u7269\u3001\u65cc\u51c6\u533b\u7597\u3001\u9605\u5fae\u57fa\u56e0\u4e09\u5bb6\u672c\u571f\u7cbe\u51c6\u533b\u7597\u4f01\u4e1a\u8fbe\u6210\u4e86\u6218\u7565\u5408\u4f5c\u4f19\u4f34\u5173\u7cfb\u3002\u57fa\u4e8e\u672c\u6b21\u6218\u7565\u534f\u8bae\uff0c\u53cc\u65b9\u5c06\u5171\u5efa\u7cbe\u51c6\u533b\u7597\u8054\u5408\u521b\u65b0\u4e2d\u5fc3\uff0c\u4ee5\u4fc3\u8fdb\u65b0\u578b\u5206\u5b50\u8bca\u65ad\u6280\u672f\u7684\u5e94\u7528\u8f6c\u5316\uff0c\u901a\u8fc7\u534f\u540c\u4ea7\u4e1a\u94fe\u4e0a\u4e0b\u6e38\u7684\u591a\u65b9\u529b\u91cf\uff0c\u5171\u5efa\u201c\u7cbe\u51c6\u533b\u7597\u751f\u6001\u7cfb\u7edf\u201d\uff0c\u4ece\u800c\u8fdb\u4e00\u6b65\u63a8\u52a8\u7cbe\u51c6\u533b\u7597\u5728\u4e2d\u56fd\u7684\u4ea7\u4e1a\u5316\uff08\u8d5b\u9ed8\u98de\u4e2d\u56fd\uff09\u3002<\/div>\n
\u00a0<\/div>\n
30.\u00a0\u91d1\u57df\u533b\u5b66\u4e0e\u5317\u4eac\u534f\u548c\u533b\u5b66\u57fa\u91d1\u4f1a\u8054\u5408\u6210\u7acb\u6bcd\u5a74\u5065\u5eb7\u4e13\u9879\u57fa\u91d1<\/div>\n
\u8fd1\u65e5\uff0c\u91d1\u57df\u533b\u5b66\u4e0e\u5317\u4eac\u534f\u548c\u533b\u5b66\u57fa\u91d1\u4f1a\u8054\u5408\u6210\u7acb\u6bcd\u5a74\u5065\u5eb7\u4e13\u9879\u57fa\u91d1\uff0c\u63a8\u5e7f\u4e92\u8054\u7f51+\u533b\u7597\uff0c\u6784\u5efa\u6bcd\u5a74\u5065\u5eb7\u6570\u636e\u5e93\uff0c\u5236\u5b9a\u6bcd\u5a74\u5065\u5eb7\u76f8\u5173\u4e13\u5bb6\u5171\u8bc6\u53ca\u4e34\u5e8a\u6307\u5357\u7b49\u3002<\/div>\n
\u00a0<\/div>\n
\u4f1a\u8bae<\/div>\n
31. 2019\u5e74CSCO\u5b66\u672f\u5e74\u4f1a\uff0c9\u670818\u65e5-22\u65e5\uff0c\u53a6\u95e8<\/div>\n
2019\u5e749\u670818\u65e5-22\u65e5\uff0c\u5c06\u5728\u798f\u5efa\u7701\u53a6\u95e8\u5e02\u56fd\u9645\u4f1a\u8bae\u4e2d\u5fc3\u53ec\u5f00\u7b2c22\u5c4a\u5168\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u5927\u4f1a\u66a82019\u5e74CSCO\u5b66\u672f\u3002\u4f1a\u8bae\u4e3b\u9898\uff1a\u521b\u65b0\u7cbe\u51c6\u7814\u7a76\u3001\u63a2\u7d22\u667a\u6167\u533b\u7597\uff08\u8be6\u60c5<\/a>\uff09\u3002<\/div>\n
\u00a0<\/div>\n
32.\u00a02019\u9996\u5c4a\u7f55\u89c1\u75c5\u5408\u4f5c\u4ea4\u6d41\u4f1a\uff0c7\u67086\u65e5-7\u65e5\uff0c\u5317\u4eac<\/div>\n
2019\u5e747\u67086\u65e5-7\u65e5\uff0c\u4ee5\u201c\u5065\u5eb7\u4e2d\u56fd\uff0c\u4e00\u4e2a\u90fd\u4e0d\u80fd\u5c11\u201d\u4e3a\u4e3b\u9898\u76842019\u9996\u5c4a\u7f55\u89c1\u75c5\u5408\u4f5c\u4ea4\u6d41\u4f1a\u5c06\u5728\u5317\u4eac\u4e3d\u90fd\u7687\u51a0\u5047\u65e5\u9152\u5e97\u4e3e\u884c\uff0c\u672c\u6b21\u5927\u4f1a\u7531\u75c5\u75db\u6311\u6218\u57fa\u91d1\u4f1a\u4e3b\u529e\uff0c\u7531\u4e2d\u56fd\u7f55\u89c1\u75c5\u8054\u76df\u6307\u5bfc\uff0c\u7531\u4e2d\u56fd\u7814\u7a76\u578b\u533b\u9662\u534f\u4f1a\u7f55\u89c1\u75c5\u5206\u4f1a\u7b49\u534f\u529e\uff08\u8be6\u60c5<\/a>\uff09\u3002<\/div>\n
\u00a0<\/div>\n
33. \u7b2c\u4e09\u5c4a\u57fa\u56e0\u5065\u5eb7\u5927\u4f1a\uff0c9\u670820\u65e5-22\u65e5\uff0c\u6210\u90fd<\/div>\n
\u4f1a\u8bae\u4e3b\u9898\u4e3a\u56f4\u7ed5\u57fa\u56e0\u5065\u5eb7\u7684\u4e34\u5e8a\u7814\u7a76\u53ca\u5e94\u7528\uff1b\u5927\u4f1a\u4e3b\u5e2d\u4e3a\u590d\u65e6\u5927\u5b66\u9a6c\u7aef\u6559\u6388\u3001\u5171\u540c\u4e3b\u5e2d\u4e3a\u6210\u90fd\u533b\u5b66\u9662\u9a6c\u65ed\u6559\u6388\uff1b\u4f1a\u8bae\u5730\u70b9\u4e3a\u6210\u90fd\u4e16\u5916\u6843\u6e90\u9152\u5e97\u3002<\/div>\n
\u00a0<\/div>\n
34.\u00a0\u4e2d\u56fd\u5352\u4e2d\u5b66\u4f1a\u7b2c\u4e94\u5c4a\u5b66\u672f\u5e74\u4f1a\u66a8\u5929\u575b\u56fd\u9645\u8111\u8840\u7ba1\u75c5\u4f1a\u8bae\uff0c6\u670828\u65e5-30\u65e5\uff0c\u5317\u4eac<\/div>\n
\u4e2d\u56fd\u5352\u4e2d\u5b66\u4f1a\u7b2c\u4e94\u5c4a\u5b66\u672f\u5e74\u4f1a\u66a8\u5929\u575b\u56fd\u9645\u8111\u8840\u7ba1\u75c5\u4f1a\u8bae2019\u5c06\u4e8e2019\u5e746\u670828\u65e5-30\u65e5\u5728\u5317\u4eac\u56fd\u5bb6\u4f1a\u8bae\u4e2d\u5fc3\u4e3e\u884c\u3002\u672c\u6b21\u5927\u4f1a\u7531\u4e2d\u56fd\u5352\u4e2d\u5b66\u4f1a\u7b49\u4e3b\u529e\uff0c\u7531\u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u5929\u575b\u533b\u9662\u7b49\u534f\u529e\uff08\u8be6\u60c5<\/a>\uff09\u3002<\/div>\n
\u00a0<\/div>\n
35.\u00a0\u7b2c\u5341\u4e5d\u5c4a\u4e2d\u534e\u9884\u9632\u533b\u5b66\u4f1a\u5fae\u751f\u6001\u5b66\u5b66\u672f\u4f1a\uff0c9\u67086\u65e5-8\u65e5\uff0c\u6d77\u5357<\/div>\n
\u7b2c\u5341\u4e5d\u5c4a\u4e2d\u534e\u9884\u9632\u533b\u5b66\u4f1a\u5fae\u751f\u6001\u5b66\u5b66\u672f\u4f1a\u8bae\u5c06\u4e8e 2019 \u5e749\u67086\u65e5-8\u65e5\u5728\u6d77\u5357\u7701\u535a\u9ccc\u4e9a\u6d32\u8bba\u575b\u4e1c\u5c7f\u5c9b\u5927\u9152\u5e97\u4e3e\u884c\u3002\u672c\u6b21\u5927\u4f1a\u7531\u4e2d\u56fd\u533b\u5e08\u534f\u4f1a\u611f\u67d3\u79d1\u533b\u5e08\u5206\u4f1a\u7b49\u4e3b\u529e\uff0c\u7531\u6d77\u5357\u7701\u533b\u5e08\u534f\u4f1a\u7b49\u534f\u529e\u3002<\/div>\n
36.\u00a0\u4e0b\u4e00\u4ee3\u80fd\u6e90\u5e94\u7528\u6750\u6599\uff0c11\u670817\u65e5-19\u65e5\uff0c\u53a6\u95e8<\/p>\n
Cell Symposium\u4e0e\u53a6\u95e8\u5927\u5b66\u80fd\u6e90\u6750\u6599\u5316\u5b66\u534f\u540c\u521b\u65b0\u4e2d\u5fc3\uff08iChEM\uff09\u5408\u4f5c\u53ec\u5f00\u201c\u4e0b\u4e00\u4ee3\u80fd\u6e90\u5e94\u7528\u6750\u6599\u201d\u7814\u8ba8\u4f1a\uff08Cell Symposium: Next-Generation Materials for Energy Applications\uff09\u3002<\/div>\n
\uff08http:\/\/www.cell-symposia.com\/energymaterials-2019\/default.asp\uff09<\/div>\n
\u00a0<\/div>\n
\u58f0\u660e\uff1a\u4ee5\u4e0a\u4fe1\u606f\u7f16\u8bd1\u6216\u6458\u5f55\u81ea\u516c\u5f00\u4fe1\u606f\uff0c\u4ec5\u7528\u4e8e\u7814\u7a76\u53c2\u8003\uff0c\u4e0d\u6784\u6210\u6295\u878d\u8d44\u7b49\u51b3\u7b56\u4f9d\u636e\uff0c\u6709\u5173\u8bc4\u8bba\u4e0d\u4ee3\u8868\u672c\u5e73\u53f0\u89c2\u70b9\u3002<\/div>\n
\u7f16\u8f91\uff1aNicole\u6821\u5bf9\uff1aDamine\u5ba1\u6838\uff1aMark\u00a0<\/div>\n
\u76f8\u5173\u63a8\u8350<\/div>\n
\u5b66\u672f\u754c\u751f\u7269\u6280\u672f\u4e13\u5229\u54ea\u5bb6\u5f3a\uff1fNature Biotechnology\u6700\u65b0\u53d1\u5e03<\/a><\/div>\n
\u5b98\u65b9\u89e3\u8bfb\u8981\u70b9\uff1a\u300a\u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u4eba\u7c7b\u9057\u4f20\u8d44\u6e90\u7ba1\u7406\u6761\u4f8b\u300b<\/a><\/div>\n
NIPT\u5e94\u7528\u53cc\u80ce\u4e0e\u5355\u80ce\u57fa\u672c\u4e00\u81f4\uff0c8\u4f4d\u4ea7\u524d\u4e13\u5bb6\u70b9\u8bc4<\/a><\/div>\n
\u00a0<\/div>\n
\u52a0\u5165\u57fa\u56e0\u6167<\/div>\n
\u884c\u4e1a\u5206\u6790\u5e08<\/div>\n
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\u65b0\u5a92\u4f53\u7f16\u8f91<\/div>\n
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\uff08\u7b80\u5386\u6295\u9012\u90ae\u7bb1\uff1a info@genonet.cn)<\/div>\n
\u00a0<\/div>\n
\u3010\u57fa\u56e0\u6167\u8bfb\u8005\u7fa4\u3011<\/div>\n
\u65e9\u4e00\u6b65\u9884\u89c1\u672a\u6765<\/div>\n
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\n![\"640?wx_fmt=jpeg\"\/](\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/RmFicvQBAkgCIniaBVXdZJGhprQkPPCBddQxw0icic5Z3nzQluvyNB7Rpib69K5AfqwTqF0pk2fLHVuroluTUG7Zwicg\/640?wx_fmt=jpeg\")
<\/figure><\/div>\n\n<\/div>\n
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