{"id":9221,"date":"2019-09-13T11:36:53","date_gmt":"2019-09-13T03:36:53","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&#038;mid=100011024&#038;idx=1&#038;sn=a6de800463a3a776cb3121939687fd9d&#038;chksm=6b715ea75c06d7b1527ce9e389d873000f633aa9a2c9ea045cb3b83057030dd590192a712995#rd"},"modified":"2026-04-08T10:13:27","modified_gmt":"2026-04-08T02:13:27","slug":"995756-2","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2019\/09\/13\/995756-2\/","title":{"rendered":"\u5341\u5e74\u540e\u6700\u8d35\u7684\u5962\u4f88\u54c1"},"content":{"rendered":"<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAA4WmWhL2xkLhvAl4UGwibibqfh8QqvFr0Vl47oQZbuYZnvotQABKR2tTPSffJcbCGpk0eQGxNq79w.jpeg\" alt=\"RmFicvQBAkgAA4WmWhL2xkLhvAl4UGwibibqfh8QqvFr0Vl47oQZbuYZnvotQABKR2tTPSffJcbCGpk0eQGxNq79w\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe1\uff1a\u4eba\uff08\u6765\u6e90\/UK Biobank\uff09<\/div>\n<div>\u5341\u5e74\u540e\u7684\u6700\u8d35\u5962\u4f88\u54c1\u662f\u4ec0\u4e48\uff1f\u6709\u4eba\u53ef\u80fd\u4f1a\u731c\u5065\u5eb7\u3002\u8fd9\u91cc\u6211\u4eec\u8c08\u6bcf\u4e2a\u4eba\u73b0\u5728\u5c31\u62e5\u6709\u7684\u3002\u4e3a\u4e86\u8fd9\u6837\u5962\u4f88\u54c1\uff0c\u82f1\u56fd\u4eca\u5929\u5ba3\u5e03\u6295\u51652\u4ebf\u82f1\u9551\uff0c50\u4e07\u5fd7\u613f\u8005\u53c2\u4e0e\uff0c\u52a0\u5de5\u8fd9\u6837\u5962\u4f88\u54c1\u7684\u5de5\u5177\u7b49\u4ef7\u52b3\u65af\u83b1\u65af\u3002\u662f\u4ec0\u4e48\u6837\u7684\u5962\u4f88\u54c1\uff0c\u548c\u6211\u6709\u4ec0\u4e48\u5173\u7cfb\uff1f\u57fa\u56e0\u6167\u9080\u8bf7\u82f1\u7279\u5c14\u533b\u7597\u3001\u4e2d\u79d1\u9662\u5317\u4eac\u57fa\u56e0\u7ec4\u6240\u3001\u795e\u5dde\u533b\u7597\u3001Congenica\u548cGeneDock\u7684\u884c\u5bb6\u4eec\u4e00\u8d77\u548c\u4f60\u804a\u804a\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u00a0\u4e00\u3001\u5b58\u50a8\u6700\u8d35\u5962\u4f88\u54c1\u7684\u751f\u7269\u94f6\u884c\u00a0\u00a0\u00a0\u00a0<\/div>\n<div>\u6545\u4e8b\u5f00\u59cb\u4e8e14\u5e74\u524d\uff082005\u5e74\uff09\u3002<\/div>\n<div>Rory Collins\u6559\u6388\u5bf9\u5927\u89c4\u6a21\u4eba\u7fa4\u7684\u5e38\u89c1\u75c5\u9884\u9632\u548c\u6cbb\u7597\u9887\u6709\u7814\u7a76\uff0c\u5728\u725b\u6d25\u5927\u5b66\u4e34\u5e8a\u5b9e\u9a8c\u4e2d\u5fc3\u548c\u6d41\u884c\u75c5\u5b66\u7814\u7a76\u4e2d\u5fc3\uff08CTSU\uff09\u505a\u8054\u5e2d\u4e3b\u4efb\uff0c\u6709\u4e00\u5929\u88ab\u82f1\u56fd\u536b\u751f\u90e8\u53eb\u53bb\uff0c\u8bf4\uff1a<\/div>\n<div>\u6709\u4e00\u4e2a\u65b0\u9879\u76ee\uff0c\u4f60\u53bb\u5f53\u8d1f\u8d23\u4eba\uff08PI\uff09\uff0c\u542f\u52a8\u8d44\u91d16200\u4e07\u82f1\u9551\u3002<\/div>\n<div>Rory Collins\u6559\u6388\u5c31\u4ece\u725b\u6d25\u642c\u5230\u5927\u66fc\u5f7b\u65af\u7279\uff0c\u4e00\u5e74\u540e\u6210\u7acb\u4e86\u4e00\u5bb6\u6709\u9650\u516c\u53f8\uff08\u6148\u5584\u673a\u6784\uff09\u3002\u8fd9\u5bb6\u516c\u53f8\u5728\u82f1\u683c\u5170\u3001\u5a01\u5c14\u58eb\u548c\u82cf\u683c\u5170\u4e09\u5730\u6ce8\u518c\u3002\u4ece\u6b64\uff0cRory Collins\u6559\u6388\u7684\u4eba\u751f\u8f68\u8ff9\u6539\u53d8\u4e86\uff0c\u8fd9\u5bb6\u673a\u6784\u4e0d\u6b62\u5f71\u54cd\u7740\u4ed6\u4e00\u4e2a\u4eba\uff0c\u5305\u62ec\u540e\u6765\u768450\u4e07\u4eba\u3001\u672a\u6765\u768450\u4ebf\u4eba\u4ee5\u53ca\u4e0d\u8ba1\u5176\u6570\u7684\u751f\u7269\u3002<\/div>\n<div>\u5b83\u7684\u540d\u5b57\u662f\uff1a\u82f1\u56fd\u751f\u7269\u94f6\u884c\uff08UK Biobank\uff09\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAA4WmWhL2xkLhvAl4UGwibib6sJqB7yLHl2fBZ5btM2hAmAPvnHV9mGJx1jcp5AKATJPDnricWq0Fvw.jpeg\" alt=\"RmFicvQBAkgAA4WmWhL2xkLhvAl4UGwibib6sJqB7yLHl2fBZ5btM2hAmAPvnHV9mGJx1jcp5AKATJPDnricWq0Fvw\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe2\uff1aRory Collins\uff08\u6765\u6e90\/Science\uff09<\/div>\n<div>\u82f1\u56fd\u751f\u7269\u94f6\u884c\u7684\u6210\u7acb<\/div>\n<div>\u82f1\u56fd\u751f\u7269\u94f6\u884c\uff08UK Biobank\uff0c\u7b80\u79f0UKB\uff09\u662f\u82f1\u56fd\u7684\u4e00\u5bb6\u6148\u5584\u673a\u6784\uff0c\u4ece\u4e8b\u5927\u578b\u3001\u957f\u671f\u7684\u751f\u7269\u5e93\u7814\u7a76\uff0c\u4e3b\u8981\u7814\u7a76\u9057\u4f20\u6613\u611f\u6027\u548c\u73af\u5883\u56e0\u7d20\u5bf9\u75be\u75c5\u53d1\u5c55\u7684\u5f71\u54cd\u3002\u00a0\u5b83\u59cb\u4e8e2006\u5e74\uff0c\u7531\u82f1\u56fd\u536b\u751f\u90e8\u3001\u533b\u5b66\u7814\u7a76\u59d4\u5458\u4f1a\u3001\u82cf\u683c\u5170\u6267\u884c\u59d4\u5458\u4f1a\u548cWellcome Trust\u533b\u5b66\u7814\u7a76\u6148\u5584\u673a\u6784\u548c\u897f\u5317\u5730\u533a\u53d1\u5c55\u5c40\u5171\u540c\u521b\u7acb\u3002UKB\u7531\u56fd\u5bb6\u5065\u5eb7\u670d\u52a1\u4e2d\u5fc3\uff08NHS\uff09\u63d0\u4f9b\u652f\u6301\uff0c\u63a5\u53d7\u5305\u62ec\u5a01\u5c14\u58eb\u653f\u5e9c\u3001\u82f1\u56fd\u5fc3\u810f\u57fa\u91d1\u4f1a\u3001\u82f1\u56fd\u764c\u75c7\u7814\u7a76\u3001\u82f1\u56fd\u7cd6\u5c3f\u75c5\u534f\u4f1a\u7684\u57fa\u91d1\u652f\u6301\uff0c\u4ee5\u53ca\u836f\u4f01\u652f\u6301\uff08\u89c1\u4e0b\u6587\uff09\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u62db\u52df\u5fd7\u613f\u8005<\/div>\n<div>\u4ece2006\u5e74\u8d77\uff0c\u82f1\u56fd\u751f\u7269\u94f6\u884c\u901a\u8fc7\u82f1\u56fd\u56fd\u6c11\u5065\u5eb7\u670d\u52a1\u4e2d\u5fc3\u62db\u52df\u5fd7\u613f\u8005\uff0c\u5de5\u4f5c\u4eba\u5458\u88ab\u8981\u6c42\u9080\u8bf7\u201c\u4efb\u4f55\u4f60\u80fd\u8bf4\u670d\u7684\u4eba\u201d\u53c2\u4e0e\uff0c\u5305\u62ec\u5bcc\u6709\u548c\u8d2b\u56f0\u4eba\u53e3\u3001\u591a\u79cd\u65cf\u591a\u5730\u533a\u4eba\u53e3\u7b49\u3002\u622a\u6b622010\u5e74\uff0c\u5171\u6709503,316\u4f4d\u3001\u5e74\u9f84\u8303\u56f4\u4e3a40\u81f369\u5c81\u3001\u5c45\u4f4f\u5728\u5404\u5730\u8bc4\u4f30\u4e2d\u5fc3\u768425\u82f1\u91cc\u8303\u56f4\u7684\u5fd7\u613f\u8005\u53c2\u4e0e\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u751f\u7269\u94f6\u884c\u5b58\u4ec0\u4e48\uff1f<\/div>\n<div>\u7814\u7a76\u4eba\u5458\u62bd\u53d6\u5fd7\u613f\u8005\u7684\u8840\u6db2\u548c\u5c3f\u6db2\uff0c\u8c03\u67e5\u4ed6\u4eec\u7684\u751f\u6d3b\u4e60\u60ef\uff0c\u5e76\u901a\u8fc7\u4eea\u5668\u7b49\u68c0\u67e52400\u591a\u79cd\u4e0d\u540c\u7684\u7279\u5f81\u6216\u8868\u578b\uff0c\u5305\u62ec\u8eab\u4f53\u4f53\u80fd\u3001\u533b\u5b66\u5f71\u50cf\u3001\u996e\u98df\u7b49\u751f\u6d3b\u65b9\u5f0f\u3001\u8ba4\u77e5\u72b6\u6001\u3001\u793e\u4ea4\u7b49\u65b9\u9762\u6570\u636e\u3002\u901a\u8fc7\u5e73\u884c\u8fdb\u884c\u7684\u4e0d\u540c\u961f\u5217\u7814\u7a76\uff0c\u622a\u6b622010\u5e74\u4e00\u5171\u83b7\u5f97486,019\u4eba\u7684\u751f\u7269\u6837\u672c\u6570\u636e\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u6709\u4ec0\u4e48\u7528\uff1f<\/div>\n<div>\u6765\u81ea\u725b\u6d25\u5927\u5b66\u7684\u9879\u76ee\u9996\u5e2d\u6d41\u884c\u75c5\u5b66\u5bb6Naomi Allen\u8868\u793a\uff0c\u201c\u6211\u4eec\u5e0c\u671b\u7ed9\u7814\u7a76\u8005\u521b\u9020\u4e00\u4e2a\u516c\u5e73\u7684\u7ade\u4e89\u73af\u5883\u201d\u3002\u6bd4\u5982\uff0c\u4ed6\u4eec\u7ed9\u51fa3\u5468\u65f6\u95f4\u8ba9\u7814\u7a76\u4eba\u5458\u6765\u4e0b\u8f7d\u6570\u636e\u52a0\u5bc6\u6587\u4ef6\u3002\u7136\u540e\u5728\u540c\u4e00\u5929\uff082017\u5e747\u670819\u65e5\uff09\u53d1\u5e03\u6700\u7ec8\u52a0\u5bc6\u5bc6\u94a5\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u5728\u53d1\u5e03\u6570\u636e\u540e\u7684\u5f88\u77ed\u65f6\u95f4\u5185\uff0c\u4e00\u4e2a\u7f8e\u56fd\u5c0f\u7ec4\u5206\u6790\u51fa\u8d85\u8fc7120,000\u79cd\u9057\u4f20\u6807\u8bb0\u4e0e\u8d85\u8fc72000\u79cd\u75be\u75c5\u548c\u7279\u5f81\u5173\u8054\uff0cBroad\u7814\u7a76\u6240\u7684\u603b\u88c1\u517c\u4e3b\u4efb\u3001\u4eba\u7c7b\u9057\u4f20\u5b66\u5bb6Eric Lander\u8bf4\uff0c\u4ee5\u524d\u53ea\u670960,000\u4e2a\u6807\u8bb0\u4e0e\u75be\u75c5\u6709\u5173\uff0c\u5728\u4e00\u5468\u5185\u7ffb\u4e86\u4e00\u756a\u3002<\/div>\n<div>\u9664\u4e86\u60c5\u6000\u548c\u79d1\u7814\uff0c\u5728\u5b9e\u9645\u751f\u4ea7\u4e2d\u5982\u4f55\uff1f\u6211\u4eec\u542c\u542c\u5168\u7403\u524d\u4e09\u7684\u836f\u4f01\u845b\u5170\u7d20\u53f2\u514b(GSK)\u7684\u6570\u636e\uff1a2016\u5e74\uff0cGSK\u7684\u65b0\u836f\u9776\u70b9\u6709\u8d85\u8fc760%\u5305\u542b\u9057\u4f20\u6807\u8bb0\u7684\u8bc1\u636e\u652f\u6301\u3002<\/div>\n<div>\u8fd9\u53ea\u662f\u6545\u4e8b\u7684\u5f00\u59cb\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u00a0\u4e8c\u30012\u4ebf\u82f1\u9551\uff0c50\u4e07\u4eba\u53c2\u4e0e\uff0c4\u5927\u836f\u5382\u6ce8\u8d44\u00a0\u00a0\u00a0\u00a0\u00a0<\/div>\n<div>\u5982\u679c\u8bf4\u4ee5\u4e0a\u4fe1\u606f\u53ef\u80fd\u56e0\u4e3a\u9971\u542b\u60c5\u6000\u3001\u751f\u6da9\u7684\u672f\u8bed\u548c\u770b\u4f3c\u5938\u5927\u7684\u673a\u6784\u540d\u79f0\uff0c\u8ba9\u4eba\u611f\u89c9\u4e0d\u63a5\u5730\u6c14\u3002\u90a3\u4e48\uff0c\u7ecf\u8fc713\u5e74\u79ef\u7d2f\u540e\u7684\u4eca\u5929\uff08\u5317\u4eac\u65f6\u95f42019\u5e749\u670812\u65e5\uff09\uff0c\u82f1\u56fd\u751f\u7269\u94f6\u884c\u5ba3\u5e03\u83b7\u5f972\u4ebf\u82f1\u9551\u6295\u8d44\uff0c50\u4e07\u4eba\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\uff0c\u56db\u5927\u836f\u5382\u53c2\u4e0e\uff0c\u8fde\u4e3a\u6b64\u9879\u76ee\u505a\u57fa\u56e0\u6d4b\u5e8f\u670d\u52a1\u7684\u516c\u53f8\u80a1\u4ef7\u4e0a\u6da84\u4e2a\u767e\u5206\u70b9\uff08\u5e02\u503c\u589e\u52a011\u4ebf\u7f8e\u5143\uff09\uff0c\u53ef\u4ee5\u8ba9\u5de5\u4e1a\u754c\u4ee5\u53ca\u6295\u8d44\u754c\u5bf9\u8fd9\u4e2a\u9879\u76ee\u4ee5\u53ca\u6240\u5728\u7684\u884c\u4e1a\u91cd\u65b0\u8ba4\u8bc6\uff1a<\/div>\n<div>\u00a0<\/div>\n<div>2\u4ebf\u82f1\u9551\u7684\u6295\u5165\u5230\u82f1\u56fd\u751f\u7269\u94f6\u884c<\/div>\n<div>\u82f1\u56fd\u653f\u5e9c\u4e3b\u7ba1\u7814\u7a76\u4e0e\u521b\u65b0\u7684\u804c\u80fd\u673a\u6784UKRI\u548cWellcome Trust\u4fe1\u6258\u57fa\u91d1\u4f1a\u5206\u522b\u6ce8\u51655000\u4e07\u82f1\u9551\u3002\u5b89\u8fdb\uff08Amgen\uff09\u3001\u963f\u65af\u5229\u5eb7\uff08AstraZeneca\uff09\u3001\u845b\u5170\u7d20\u53f2\u514b\uff08GSK\uff09\u4ee5\u53ca\u5f3a\u751f\uff08J\uff06J\uff09\u56db\u5bb6\u5236\u836f\u516c\u53f8\u5171\u6295\u51651\u4ebf\u82f1\u9551\u3002<\/div>\n<div>\u00a0<\/div>\n<div>2\u4ebf\u82f1\u9551\u7528\u4e8e\u505a\u4ec0\u4e48\uff1f<\/div>\n<div>\u5bf9\u82f1\u56fd\u751f\u7269\u94f6\u884c\u768450\u4e07\u540d\u53c2\u4e0e\u8005\u8fdb\u884c\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u3002\u4e4b\u524d\u9879\u76ee\u6709\u5bf9\u90e8\u5206\u53c2\u4e0e\u8005\u8fdb\u884c\u5c40\u90e8\u6d4b\u5e8f\u6216\u57fa\u56e0\u4f4d\u70b9\u82af\u7247\u5206\u6790\uff0c\u800c\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u662f\u5bf930\u4ebf\u4e2a\u4f4d\u70b9\uff0c\u7ea625000\u591a\u4e2a\u57fa\u56e0\u5168\u90e8\u6d4b\u5e8f\uff08\u622a\u6b62\u52302019\u5e749\u67084\u65e5\uff0c\u5171\u6d4b\u5f97820,967\u4e2a\u4f4d\u70b9\uff09\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u9879\u76ee\u7684\u53c2\u4e0e\u670d\u52a1\u673a\u6784<\/div>\n<div>1\uff09\u6d4b\u5e8f\u751f\u4ea7\u5e73\u53f0\uff1aIllumina\uff08Nasdq:ILMN\uff09<\/div>\n<div>\uff08\u6ce8\uff1a\u6309\u7167\u516c\u5e03\u7684\u6295\u5165\u91d1\u989d\u53ca\u4eba\u6570\uff0c\u5e73\u5747\u6bcf\u4e2a\u53c2\u4e0e\u8005\u7684\u6d4b\u5e8f\u8d39\u7528\u662f3140\u5143\uff0c\u8fd9\u4f4e\u4e8e\u76ee\u524d\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u7684\u6210\u672c\uff0c\u4f46\u4ecd\u9ad8\u4e8e\u6211\u56fd2016\u5e74\u542f\u52a8\u7684\u7cbe\u51c6\u533b\u5b66\u961f\u5217\u7814\u7a76\u7684\u5e73\u5747\u6bcf\u4eba\u7684\u6d4b\u5e8f\u8d39\u7528\u3002\u4e8c\u8005\u5747\u9700\u4ee5\u5176\u4ed6\u65b9\u5f0f\u7b79\u63aa\u8d44\u91d1\uff09<\/div>\n<div>2\uff09\u6d4b\u5e8f\u670d\u52a1\u673a\u6784\uff1aWellcome Sanger Institute \u4ee5\u53cadeCODE Genetics\u3002<\/div>\n<div>\uff08\u6ce8\uff1a\u524d\u8005\u662f\u82f1\u56fd\u4e43\u81f3\u5168\u7403\u6700\u77e5\u540d\u7684\u9057\u4f20\u5b66\u4e2d\u5fc3\uff0c\u8d1f\u8d2322.5\u4e07\u4f8b\u6837\u672c\u6d4b\u5e8f\uff0c\u540e\u8005\u662f\u4e3a\u51b0\u5c9b\u5168\u56fd\u4eba\u53e3\u8fdb\u884c\u6d4b\u5e8f\u7684\u8001\u724c\u57fa\u56e0\u516c\u53f8\uff0c\u540e\u6765\u88ab\u5206\u62c6\u5356\u7ed9Amgen\uff0c\u8be6\u60c5\u89c1<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247494636&amp;idx=2&amp;sn=70205fb2fefa4598c5c141bc99463973&amp;chksm=eb71595bdc06d04dae256384c540b0c1d151f50812c75725029f5b32f87c436456d6dd4811e3&amp;scene=21#wechat_redirect\">\u5386\u53f2\u6587\u7ae0<\/a>\uff09<\/div>\n<div>\u00a0<\/div>\n<div>\u9879\u76ee\u8ba1\u5212<\/div>\n<div>1\uff09\u8bd5\u70b9\uff1aWellcome Sanger Institute\u7387\u5148\u5b8c\u6210\u4e8610%\uff0c\u537350,000\u4eba\u7684\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u7684\u8bd5\u70b9\u9879\u76ee\u3002<\/div>\n<div>2\uff09\u5206\u6279\u5b8c\u6210\uff1a\u5269\u4e0b90%\uff0c\u5206\u4e24\u6279\u5b8c\u6210\uff0c\u7b2c\u4e00\u627912.5\u4e07\u4eba\u5168\u57fa\u56e0\u7ec4\u4fe1\u606f\u9884\u8ba1\u57282021\u5e74\u6625\u5b63\u4f9b\u6240\u6709\u7814\u7a76\u4eba\u5458\u8bbf\u95ee\uff0c\u5c4a\u65f6\u8bd5\u70b9\u9879\u76ee\u76845\u4e07\u4eba\u6570\u636e\u4e5f\u5c06\u540c\u6b65\u5f00\u653e\u3002\u7b2c\u4e8c\u6279\u9884\u8ba1\u5c06\u4e8e2021\u5e74\u590f\u5929\u5b8c\u6210\u3002<\/div>\n<div>3\uff09\u6570\u636e\u5f00\u653e\uff1a\u6574\u4e2a\u82f1\u56fd\u751f\u7269\u6837\u672c\u5e93\u5fd7\u613f\u8005\u7684\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6570\u636e\u9884\u8ba1\u5c06\u57282023\u5e74\u521d\u5168\u90e8\u5f00\u653e\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8be5\u9879\u76ee\u7684\u4ea7\u4e1a\u5408\u4f5c\u4f19\u4f34\u5c06\u5728\u524d9\u4e2a\u6708\u7684\u65f6\u95f4\u5185\u4f18\u5148\u83b7\u53d6\u6570\u636e\u8d44\u6e90\uff0c\u4e4b\u540e\u7684\u6570\u636e\u7533\u8bf7\u9700\u901a\u8fc7\u76f8\u5173\u51c6\u5165\u59d4\u5458\u4f1a\u7684\u534f\u8bae\u8fdb\u884c\u3002\u6b64\u5916\uff0c\u57fa\u56e0\u5206\u578b\u6570\u636e\u548c\u5916\u663e\u5b50\u6570\u636e\u5206\u522b\u57282015\u5e743\u6708\u548c2019\u5e743\u6708\u9646\u7eed\u5f00\u653e\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u9879\u76ee\u6574\u4f53\u65f6\u95f4\u8868\u89c1\u56fe2\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAA4WmWhL2xkLhvAl4UGwibib96nM3FAllzFcGciadjqfJak6NibIm2aLLE0RGPhnG0Nsdn0OT51RuxRA.png\" alt=\"RmFicvQBAkgAA4WmWhL2xkLhvAl4UGwibib96nM3FAllzFcGciadjqfJak6NibIm2aLLE0RGPhnG0Nsdn0OT51RuxRA\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe3\uff1a\u82f1\u56fd\u751f\u7269\u94f6\u884c\u7684\u8def\u7ebf\u56fe\uff08\u6765\u6e90\/Science\uff09<\/div>\n<div>\u00a0\u4e09\u3001\u82f1\u56fd\u751f\u7269\u94f6\u884c\u5bf9\u6211\u4eec\u7684\u542f\u793a\u00a0 \u00a0\u00a0\u00a0<\/div>\n<div>\u5728\u957f\u8fbe20\u4f59\u5e74\u7684\u89c4\u5212\u91cc\uff0c\u751f\u7269\u94f6\u884c\u7684\u610f\u4e49\uff0c\u9664\u4e86\u201c\u5b58\u6570\u636e\u201d\uff0c\u66f4\u591a\u5730\u662f\u4e3a\u4e86\u5b9e\u73b0\u7cbe\u51c6\u533b\u5b66\u3002\u5176\u4e2d\u7684\u4ef7\u503c\u8861\u91cf\uff0c\u53ef\u4ee5\u770b\u4e0b\u9762\u4e00\u7ec4\u6570\u636e\u3002<\/div>\n<div>2016\u5e74\uff0c\u82f1\u56fd\u533b\u5b66\u7814\u7a76\u59d4\u5458\u4f1a\uff08MRC\uff09\u3001Wellcome Trust\u548c\u82f1\u56fd\u5fc3\u810f\u57fa\u91d1\u4f1a\uff08BHF\uff09\u5408\u4f5c\u8017\u8d444300\u4e07\u82f1\u9551\u5bf9\u82f1\u56fd\u751f\u7269\u94f6\u884c\u7684100,000\u540d\u53c2\u4e0e\u8005\u7684\u5927\u8111\uff0c\u5fc3\u810f\uff0c\u9aa8\u9abc\uff0c\u9888\u52a8\u8109\u548c\u8179\u90e8\u8102\u80aa\u8fdb\u884c\u6210\u50cf\u3002<\/div>\n<div>2018\u5e74\uff0c\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u6765\u81ea\u82f1\u56fd\u751f\u7269\u94f6\u884c\u7684\u8111\u56fe\u50cf\u4ee5\u53ca\u57fa\u56e0\u7ec4\u6570\u636e\uff0c\u53d1\u73b0\u4e0e\u7cbe\u795e\u5206\u88c2\u75c7\u3001\u6291\u90c1\u75c7\u7b49\u7cbe\u795e\u969c\u788d\u6709\u5173\uff0c\u4ee5\u53ca\u4e0e\u5e15\u91d1\u68ee\u75c5\u6216\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7b49\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u6709\u5173\u7684\u57fa\u56e0\uff0c\u6709\u671b\u672a\u6765\u5b83\u53ef\u4ee5\u5e2e\u52a9\u65e9\u671f\u8bca\u65ad[11]\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u76f4\u63a5\u9762\u5411\u6d88\u8d39\u8005\u7684\u57fa\u56e0\u68c0\u6d4b\u516c\u53f823andMe\u4e0e14\u5bb6\u516c\u53f8\u7b7e\u7f72\u4e86\u5408\u4f5c\u534f\u8bae\u3002\u5176\u4e2d\u5305\u62ec\u4e0e\u836f\u4f01Genentech\u5408\u4f5c\uff0c\u5141\u8bb8\u5176\u5bf9\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u7684\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6570\u636e\u8fdb\u884c\u5206\u6790\uff0c\u5408\u4f5c\u91d1\u989d\u4e3a6000\u4e07\u7f8e\u5143\u3002<\/div>\n<div>\u6b63\u5982\u82f1\u7279\u5c14\u533b\u7597\u4e0e\u751f\u547d\u79d1\u5b66\u4e8b\u4e1a\u90e8\u8d1f\u8d23\u4eba\u674e\u5065\u63a5\u53d7\u57fa\u56e0\u6167\u91c7\u8bbf\u8868\u793a\uff0c\u56db\u5927\u533b\u836f\u5de8\u5934\u53c2\u4e0e\u5230\u56fd\u5bb6\u7ea7\u7cbe\u51c6\u533b\u5b66\u7814\u7a76\u4e2d\u6765\uff0c\u65e0\u7591\u8bc1\u660e\u4e86\u7cbe\u51c6\u533b\u7597\u65b9\u5411\u7684\u51c6\u786e\u6027\u548c\u524d\u77bb\u6027\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u5728\u5546\u4e1a\u5c42\u9762\uff0c\u751f\u7269\u94f6\u884c\u7684\u4ef7\u503c\u6838\u5fc3\u662f\u5f62\u6210\u533b\u7597\u5065\u5eb7\u7684\u5faa\u8bc1\u8bc1\u636e\u94fe\u3002\u4ece\u79d1\u7814\u8f6c\u5316\u5e94\u7528\uff0c\u836f\u5382\u7684\u53c2\u4e0e\u5f88\u91cd\u8981\uff0c\u524d\u963f\u91cc\u5df4\u5df4\u53cb\u76df\u9996\u5e2d\u6570\u636e\u79d1\u5b66\u5bb6\u3001GeneDock\u521b\u59cb\u4eba\u674e\u53a6\u620e\u8ba4\u4e3a\uff0c\u80fd\u591f\u8ba9\u9879\u76ee\u8bbe\u8ba1\u4ee5\u7ec8\u4e3a\u59cb\uff0c\u4ece\u6570\u636e\u5728\u4e34\u5e8a\u3001\u836f\u7269\u7814\u53d1\u8f6c\u5316\u4ef7\u503c\u7684\u89d2\u5ea6\uff0c\u53bb\u63a2\u7d22\u5927\u578b\u961f\u5217\u7684\u7ec4\u7ec7\u548c\u6267\u884c\u65b9\u5f0f\uff0c\u8ba9\u6570\u636e\u5927\u800c\u6709\u7528\u3002Congenica 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Button\u201d\u8ba1\u5212\u7b49\u7684\u6709\u5e8f\u5171\u4eab\u3002<\/div>\n<div>\u9762\u5411\u672a\u6765\uff0c\u5b66\u4e60\u56fd\u9645\u7ecf\u9a8c\uff0c\u6211\u56fd\u5728\u57fa\u56e0\u53ca\u751f\u547d\u5065\u5eb7\u9886\u57df\u6709\u7740\u6781\u4f73\u7684\u4ece\u5e76\u8dd1\u5230\u9886\u8dd1\u7684\u7a97\u53e3\u671f\u3002<\/div>\n<div>\u00a0<\/div>\n<div>Congenica \u4e2d\u56fd\u603b\u7ecf\u7406\u674e\u8f89\u8f89\u8ba4\u4e3a\uff0c\u901a\u8fc7\u56fd\u5bb6\u653f\u5e9c\u4e3b\u5bfc\u5efa\u7acb\u76f8\u5e94\u7684\u4eba\u7fa4\u53c2\u8003\u57fa\u56e0\u7ec4\u53ca\u4eba\u7fa4\u57fa\u56e0\u9891\u7387\u6570\u636e\u5e93\u662f\u5f88\u6709\u5fc5\u8981\u7684\u4e00\u9879\u57fa\u7840\u5de5\u4f5c\u3002\u540c\u65f6\u8fd9\u4e9b\u7fa4\u4f53\u57fa\u56e0\u7ec4\u7814\u7a76\u5927\u90fd\u56f4\u7ed5\u7f55\u89c1\u75c5\u53ca\u764c\u75c7\u7b49\u4e24\u65b9\u9762\u5c55\u5f00\uff0c\u4e5f\u662f\u4f5c\u4e3a\u5168\u57fa\u56e0\u7ec4\u68c0\u6d4b\u8fdb\u5165\u4e34\u5e8a\u5e94\u7528\u53ca\u536b\u751f\u4f53\u7cfb\u7684\u4e00\u4e2a\u6982\u5ff5\u9a8c\u8bc1\u548c\u673a\u5236\u5efa\u8bbe\u3002\u82f1\u56fd\u5341\u4e07\u4eba\u57fa\u56e0\u7ec4\u8ba1\u5212\u9010\u6e10\u8fdb\u5165\u5c3e\u58f0\uff0c\u4f46\u662f\u56f4\u7ed5\u5341\u4e07\u4eba\u57fa\u56e0\u53d8\u5f02\u6570\u636e\u5e93\u7684\u5546\u4e1a\u5316\u5f00\u53d1\u548c\u5e94\u7528\u624d\u521a\u521a\u5f00\u59cb\u4e0d\u65ad\u52a0\u5f3a\u548c\u4ea7\u4e1a\u7684\u5408\u4f5c\uff0c\u6700\u5927\u5316\u9879\u76ee\u6240\u79ef\u7d2f\u7684\u6570\u636e\u8d44\u6e90\u53ca\u4ef7\u503c\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u5728\u6211\u56fd\u7684\u57fa\u56e0\u7b49\u524d\u6cbf\u751f\u7269\u6280\u672f\u9886\u57df\uff0c\u8bde\u751f\u4e86\u7c7b\u4f3c\u534e\u5927\u667a\u9020\u81ea\u4e3b\u7814\u53d1\u57fa\u56e0\u4fe1\u606f\u4e0a\u6e38\u8bbe\u5907\u673a\u6784\uff0c\u8d70\u5411\u82f1\u56fd\u7684\u8fc8\u745e\u7b49\u77e5\u540d\u7b2c\u4e09\u65b9\u68c0\u6d4b\u673a\u6784\uff0c\u4ee5\u53ca\u5438\u5f15\u5230\u56de\u56fd\u521b\u4e1a\u7684\u57fa\u56e0\u7f16\u8f91\u4f18\u8d28\u521b\u65b0\u56e2\u961f\u542f\u83e1\u751f\u7269\u7b49\uff0c\u4e5f\u53ef\u4ee5\u770b\u5230\u57fa\u56e0\u7ea7\u751f\u547d\u5065\u5eb7\u5927\u6570\u636e\u7684\u91c7\u96c6\u3001\u5206\u6790\u3001\u89e3\u8bfb\u548c\u5e94\u7528\u7684\u4ea7\u4e1a\u94fe\u96cf\u5f62\u521d\u5907\uff0c\u800c\u5404\u5730\u65b9\u4ea7\u4e1a\u56ed\u7684\u4ea7\u4e1a\u96c6\u7fa4\u5efa\u8bbe\u6b63\u5438\u5f15\u76f8\u5e94\u4eba\u624d\u548c\u8d44\u672c\u3002\u800c\u4e14\uff0c\u5728\u5f53\u524d\u79d1\u6280\u521b\u65b0\u3001\u4ea7\u4e1a\u5347\u7ea7\u4ee5\u53ca\u6c11\u751f\u5927\u5065\u5eb7\u9700\u6c42\u4e0b\uff0c\u957f\u5468\u671f\u3001\u5927\u6295\u5165\u7684\u57fa\u7840\u7814\u7a76\u6b63\u5728\u79ef\u7d2f\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u4f8b\u5982\uff0c\u6211\u56fd\u81ea2016\u5e74\u4e5f\u542f\u52a8\u4e86\u4e3a\u51763-5\u5e74\u201c\u7cbe\u51c6\u533b\u5b66\u7814\u7a76\u201d\u56fd\u5bb6\u91cd\u70b9\u4e13\u9879\uff0c\u5305\u62ec\u8fd1\u767e\u4e07\u4eba\u53e3\u7684\u5305\u62ec\u57fa\u56e0\u3001\u4e13\u75c5\u53ca\u5730\u533a\u7684\u4eba\u7fa4\u961f\u5217\u7814\u7a76\u3002\u8c08\u5230\u8fd9\u4e2a\u7cfb\u5217\u9879\u76ee\u65f6\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u5317\u4eac\u57fa\u56e0\u7ec4\u7814\u7a76\u6240\u7814\u7a76\u5458\u65b9\u5411\u4e1c\u5bf9\u57fa\u56e0\u8868\u793a\uff0c\u76ee\u524d\u767e\u4e07\u81ea\u7136\u961f\u5217\u5efa\u7acb\u57fa\u672c\u5b8c\u6210\uff0c2-3\u5e74\u4e00\u6b21\u3001\u968f\u8bbf2\u6b21\u4ee5\u4e0a\u7684\u8d85\u8fc73\/4 \uff0c\u6709\u57fa\u56e0\u4fe1\u606f\u768420%\u3002\u5305\u62ec\u98df\u7ba1\u764c\u3001\u80ba\u764c\u3001\u6162\u963b\u80ba\u3001\u5fc3\u8840\u7ba1\u75c5\u7b49\u961f\u5217\u8d85\u8fc750\u4e07\u4eba\u53e3\uff0c\u800c\u5305\u542b\u57fa\u56e0\u6570\u636e\u7684\u6837\u672c\u91cf\u4e0d\u591a\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u9664\u4e86\u201c\u7cbe\u51c6\u533b\u5b66\u7814\u7a76\u201d\u7b49\u56fd\u5bb6\u91cd\u70b9\u4e13\u9879\uff0c\u6211\u56fd\u5341\u4e07\u4eba\u57fa\u56e0\u7ec4\u8ba1\u5212\u4e5f\u6b63\u5728\u8fdb\u884c\uff0c\u5e76\u4e14\u4ee5\u6b64\u548c\u4ea7\u4e1a\u56ed\u7b49\u5b9e\u4f53\u7ed3\u5408\uff0c\u672a\u6765\u4ecd\u9700\u81f3\u5c11\u957f\u671f\u57fa\u7840\u7814\u7a76\u548c\u8f6c\u5316\u6295\u5165\uff0c\u800c\u65e0\u8bba\u6c11\u751f\u5065\u5eb7\u8fd8\u662f\u65b0\u836f\u751f\u4ea7\uff0c\u90fd\u7559\u7ed9\u751f\u7269\u5927\u6570\u636e\u4ea7\u5b66\u7814\u534f\u4f5c\u8005\u5e7f\u88a4\u7684\u7a7a\u95f4\uff0c\u5728\u4e91\u8ba1\u7b97\u548c5G\u7b49\u5927\u6570\u636e\u6280\u672f\u52a0\u6301\u4e0b\uff0c\u81f3\u5c11\u670910\u5e74\u7684\u9ec4\u91d1\u65f6\u671f\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u53c2\u8003\u8d44\u6599\uff1a<\/div>\n<div>1\uff09http:\/\/www.ukbiobank.ac.uk\/about-biobank-uk<\/div>\n<div>2\uff09https:\/\/www.sanger.ac.uk\/news\/view\/500000-whole-human-genomes-will-be-game-changer-research-human-diseases<\/div>\n<div>3)\u00a0http:\/\/sitn.hms.harvard.edu\/flash\/2019\/from-genes-to-disease-the-release-of-the-uk-biobank<\/div>\n<div>4)\u00a0https:\/\/www.ukbiobank.ac.uk\/2019\/09\/uk-biobank-leads-the-way-in-genetics-research-to-tackle-chronic-diseases-2<\/div>\n<div>5)\u00a0http:\/\/www.nealelab.is\/uk-biobank<\/div>\n<div>6)\u00a0https:\/\/www.maelstrom-research.org\/mica\/individual-study\/ukb<\/div>\n<div>7)\u00a0https:\/\/www.sciencemag.org\/news\/2019\/01\/huge-trove-british-biodata-unlocking-secrets-depression-sexual-orientation-and-more?et_cid=2581485&amp;et_rid=396464808<\/div>\n<div>8\uff09https:\/\/www.ukbiobank.ac.uk\/rory-collins<\/div>\n<div>9\uff09https:\/\/www.nature.com\/articles\/d41586-019-01739-w<\/div>\n<div>10\uff09https:\/\/www.marketwatch.com\/press-release\/uk-biobank-regeneron-and-gsk-announce-largest-gene-sequencing-initiative-on-worlds-most-detailed-health-database-to-improve-drug-discovery-and-disease-diagnosis-2017-03-22<\/div>\n<div>11)\u00a0https:\/\/www.nature.com\/articles\/s41586-018-0571-7#Sec7<\/div>\n<div>\uff08\u5c01\u9762\u56fe\u6765\u6e90\uff1aUK Biobank\uff09<\/div>\n<div>\u00a0<\/div>\n<div>\u58f0\u660e\uff1a\u4ee5\u4e0a\u884c\u4e1a\u8d44\u8baf\u6216\u5206\u6790\u6587\u7ae0\uff0c\u4ec5\u4ee3\u8868\u4e2a\u4eba\u89c2\u70b9\uff0c\u4ec5\u4f9b\u7814\u7a76\u53c2\u8003\uff0c\u4e0d\u4f5c\u4e3a\u6295\u878d\u8d44\u53ca\u533b\u7597\u7b49\u51b3\u7b56\u4f9d\u636e\uff1b\u77e5\u8bc6\u7248\u6743\u5c5e\u4e8e\u57fa\u56e0\u6167\uff0c\u673a\u6784\u8f6c\u8f7d\u8bf7\u5f81\u5f97\u57fa\u56e0\u6167\u4e66\u9762\u540c\u610f\u540e\uff0c\u5728\u6587\u7ae0\u9996\u884c\u7f72\u540d\u8f6c\u8f7d\u51fa\u5904\u53ca\u4f5c\u8005\uff0c\u6b22\u8fce\u4e2a\u4eba\u8f6c\u53d1\u81f3\u670b\u53cb\u5708\u53ca\u7fa4\u5206\u4eab\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u00a0\u62d3\u5c55\u9605\u8bfb\u00a0<\/div>\n<div><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247494636&amp;idx=2&amp;sn=70205fb2fefa4598c5c141bc99463973&amp;chksm=eb71595bdc06d04dae256384c540b0c1d151f50812c75725029f5b32f87c436456d6dd4811e3&amp;scene=21#wechat_redirect\">\u57fa\u56e0\u4ea7\u4e1a\u53d1\u5c55\u7684\u5fc5\u7136\u6027\u548c\u5207\u5165\u70b9<\/a><\/div>\n<div><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247494461&amp;idx=1&amp;sn=af47d0f2ac77180e6d469e35a80d2b1d&amp;chksm=eb71598adc06d09c7ac23791608291b33fac24eaa5d0f842003f82f761461ddb40a2b47556a7&amp;scene=21#wechat_redirect\">2019\u5e74\u534a\u7a0b\uff0c\u57fa\u56e0\u4ea7\u4e1a\u5206\u6790\uff08\u4e0a\uff09<\/a><\/div>\n<div>\u00a0<\/div>\n<div>\u52a0\u5165\u57fa\u56e0\u6167\u8bfb\u8005\u7fa4\u6216\u5408\u4f5c<\/div>\n<div>\u6dfb\u52a0\u5fae\u4fe1 jiyinhui_1<\/div>\n<div>\u53e3\u4ee4\uff1a\u5355\u4f4d-\u804c\u4f4d-\u59d3\u540d\uff08\u901a\u8fc7\u540e\u8d50\u540d\u7247\uff09<\/div>\n<div>\u00a0<\/div>\n<div>\u3010\u5173\u4e8e\u57fa\u56e0\u6167\u3011<\/div>\n<div>\u57fa\u56e0\u6167\u662f\u4e00\u5bb6\u57fa\u56e0\u548c\u6570\u5b57\u751f\u547d\u5065\u5eb7\u4ea7\u4e1a\u54a8\u8be2\u673a\u6784\uff0c\u57fa\u4e8e\u5341\u5e74\u4ea7\u4e1a\u5b9e\u8df5\uff0c\u5efa\u7acb\u4e86\u884c\u4e1a\u667a\u5e93\u548c\u4f01\u4e1a\u5e93YourMap\u4ee5\u53ca\u4f20\u5a92\u5e73\u53f0\uff0c\u63d0\u4f9b\u4e13\u4e1a\u7684\u54a8\u8be2\u3001\u54c1\u724c\u53ca\u4fe1\u606f\u670d\u52a1\uff0c\u5e2e\u52a9\u5408\u4f5c\u4f19\u4f34\u6d1e\u5bdf\u5e02\u573a\uff0c\u5148\u4e00\u6b65\u770b\u89c1\u672a\u6765\u3002<\/div>\n<div>\u3010\u884c\u4e1a\u8ba4\u53ef\u3011<\/div>\n<div>\u2606 \u56fd\u5bb6\u53d1\u6539\u59d4\u300a2019\u5e74\u6218\u7565\u6027\u65b0\u5174\u4ea7\u4e1a\u53d1\u5c55\u53ca\u5c55\u671b\u300b\u7f16\u59d4<\/div>\n<div>\u2606 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href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247493095&amp;idx=1&amp;sn=86d94a4dd4f7a9629a7f30f8c9bd761c&amp;chksm=eb715750dc06de4680bc88f2be4e00c3320074a0edd4c91393590a7518b890383fb1a5c88343&amp;scene=21#wechat_redirect\">\u300a\u57fa\u56e0\u884c\u4e1a\u62a5\u544a\u300b<\/a><\/div>\n<div>\u2606 \u7b2c\u4e5d\u5c4a\u4e2d\u56fd\u6df1\u5733\u521b\u65b0\u521b\u4e1a\u5927\u8d5b\u76d0\u7530\u533a\u51b3\u7b56\u8bc4\u59d4<\/div>\n<div>\u2606\u00a0<a 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