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\"640?wx_fmt=png\"\/<\/figure><\/div>\n\n
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\"640?wx_fmt=jpeg\"\/<\/figure><\/div>\n\n
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\"640?wx_fmt=png\"\/<\/figure><\/div>\n\n
\u56fe2\uff1a\u80ba\u764c\uff08\u817a\u764c\uff09\u7684\u5206\u5b50\u5206\u578b\uff08\u6765\u6e90\/LUNGevity\uff09<\/div>\n
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\u00a0<\/div>\n
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\u00a0<\/div>\n
\u5728\u63a5\u53d7\u57fa\u56e0\u6167\uff08\u5fae\u4fe1\u516c\u4f17\u53f7\uff1aGeneClub-1\uff09\u91c7\u8bbf\u65f6\uff0c\u5409\u56e0\u52a0\u7684\u674e\u6e05\u6797\u603b\u76d1\u8868\u793a\uff0c\u5409\u56e0\u52a0\u548c\u963f\u91cc\u65af\u5eb7\u5408\u4f5c\u70b9\u4e3b\u8981\u662f\u57fa\u4e8e\u5409\u56e0\u52a0\u7684\u56fd\u4ea7\u6d4b\u5e8f\u5e73\u53f0<\/a>\u548c\u914d\u5957\u8bd5\u5242\u76d2\uff0c\u7ed3\u5408\u963f\u65af\u5229\u5eb7\u7684\u6e20\u9053\u4e0b\u6c89\uff0c\u5728\u4e09\u56db\u7ebf\u57ce\u5e02\u6269\u5927\u60a3\u8005\u6559\u80b2\u548c\u7cbe\u51c6\u7528\u836f\u7684\u8986\u76d6\u8303\u56f4\u3002\u540c\u6837\u548c\u963f\u91cc\u65af\u5eb7\u5408\u4f5c\u7684\u6cdb\u751f\u5b50\u57fa\u56e0\u544a\u8bc9\u57fa\u56e0\u6167\uff0c\u76ee\u524d\u4e0e\u963f\u65af\u5229\u5eb7\u7684\u5408\u4f5c\u56ca\u62ec\u4e86\u79d1\u7814\u5927\u6570\u636e\uff0c\u4e34\u5e8a\u53ca\u4e0a\u5e02\u540e\u63a8\u5e7f\uff0c\u4ee5\u53ca\u4e00\u4e9b\u7279\u5b9a\u65b9\u5411\u7684\u6148\u5584\u9879\u76ee\u53ca\u5546\u4e1a\u5316\u5408\u4f5c\u5c1d\u8bd5\u7b49\u3002<\/div>\n
\u00a0<\/div>\n
\u963f\u65af\u5229\u5eb7\u5174\u5e08\u52a8\u4f17\u7684\u80bf\u7624\u4f34\u968f\u8bca\u65ad\u7684\u610f\u4e49\u662f\u4ec0\u4e48\uff1f<\/div>\n
\u9996\u5148\u6211\u4eec\u5f15\u7528\u80bf\u7624\u57fa\u56e0\u516c\u53f8Myriad\u526f\u603b\u88c1Johnathan Lancaste\u516c\u5f00\u7684\u4e00\u6bb5\u8bdd\uff1a<\/div>\n
\u4f34\u968f\u8bca\u65ad\u5de5\u5177\u8ba9\u6211\u4eec\u80fd\u591f\u4e86\u89e3\u764c\u7ec6\u80de\u8868\u578b\u80cc\u540e\u7684\u9057\u4f20\u6539\u53d8\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u53ef\u4ee5\u4f7f\u6211\u4eec\u80fd\u591f\u6839\u636e\u60a3\u8005\u81ea\u8eab\u80bf\u7624\u7684\u751f\u7269\u5b66\u7279\u6027\uff0c\u4f7f\u60a3\u8005\u63a5\u53d7\u4e2a\u6027\u5316\u6cbb\u7597\u3002\u8fd9\u662f\u60a3\u8005\u611f\u5174\u8da3\u7684\u4e8b\u60c5\uff0c\u56e0\u4e3a\u53ef\u4ee5\u589e\u5f3a\u6cbb\u7597\u4fe1\u5fc3\u3002<\/div>\n
\u00a0<\/div>\n
\u6839\u636e\u7f8e\u56fdFDA\u7684\u5b9a\u4e49\uff0c\u4f34\u968f\u8bca\u65ad\u7684\u4f5c\u7528\u4f53\u73b0\u5728\uff1a\u5728\u524d\u671f\uff0c\u53ef\u4ee5\u786e\u5b9a\u54ea\u4e9b\u60a3\u8005\u6700\u6709\u53ef\u80fd\u53d7\u76ca\u4e8e\u7279\u5b9a\u7684\u6cbb\u7597\u4ea7\u54c1\uff08\u5305\u62ec\u526f\u4f5c\u7528\u7b49\uff09\uff1b\u5728\u4e2d\u540e\u671f\uff0c\u76d1\u63a7\u80fd\u591f\u63d0\u4f9b\u60a3\u8005\u9488\u5bf9\u7279\u5b9a\u6cbb\u7597\u836f\u7269\u7684\u6cbb\u7597\u53cd\u5e94\u4ee5\u4fbf\u8c03\u6574\u6cbb\u7597\u3002<\/div>\n
\u5728\u5b9e\u9645\u5e94\u7528\u573a\u666f\u4e2d\uff0c\u5305\u62ec\u4e34\u5e8a\u6307\u5bfc\u7528\u836f\u4ee5\u53ca\u4e34\u5e8a\u8bd5\u9a8c\u5165\u7ec4\u4e24\u65b9\u9762\u3002\u57fa\u56e0\u6167\u83b7\u6089\uff0c\u76ee\u524d\u8d85\u8fc790%\u662f\u96c6\u4e2d\u5728\u524d\u8005\uff0c\u540e\u8005\u4e3b\u8981\u96c6\u4e2d\u5728\u4e00\u7ebf\u57ce\u5e02\u6709\u4e34\u5e8a\u8bd5\u9a8c\u7684PI\u5b9e\u9a8c\u7ec4\u91cc\u3002<\/div>\n
\u00a0<\/div>\n
1998\u5e74\u4e73\u817a\u764c\u9776\u5411\u836f\u8d6b\u8d5b\u6c40\uff08Herceptin\uff09\u83b7\u6279\uff0c\u5176\u4f34\u968f\u8bca\u65ad\u751f\u7269\u6807\u5fd7\u7269\u4e3aHER2\u57fa\u56e0\uff0c\u7ea620%\u4e73\u817a\u764c\u60a3\u8005\u7684HER2\u57fa\u56e0\u8fc7\u8868\u8fbe\uff0c\u4f7f\u7528\u8d6b\u8d5b\u6c40\u540e10\u5e74\u751f\u5b58\u671f\u4ece75%\u589e\u5927\u81f384%\u3002\u7531\u6b64\u5f00\u542f\u4e86\u9776\u5411\u836f\u53ca\u4f34\u968f\u8bca\u65ad\u5feb\u901f\u53d1\u5c55\u65f6\u4ee3\uff0c\u622a\u81f32019\u5e748\u6708\uff0c\u7ecf\u8fc7FDA\u8ba4\u8bc1\u6216\u6279\u51c6\u7684\u4f34\u968f\u8bca\u65ad\u4ea7\u54c1\u5df2\u670937\u79cd[6]\u3002\u76ee\u524dFDA\u4e00\u822c\u662f\u5bf9\u65b0\u836f\u548c\u5176\u4f34\u968f\u8bca\u65ad\u4ea7\u54c1\u540c\u65f6\u6279\u51c6\u4e0a\u5e02\u3002<\/div>\n
\u00a0<\/div>\n
\u81ea2014\u5e74\u6765\uff0cFDA\u9646\u7eed\u51fa\u53f0\u4f34\u968f\u8bca\u65ad\u76f8\u5173\u7684\u89c4\u8303\u6587\u4ef6\uff08\u5982\u88681\uff09\u3002<\/div>\n
\u65f6\u95f4FDA\u53d1\u5e03\u6587\u4ef6\u8981\u70b92014Guidance for Industry: In Vitro Companion Diagnostic Devices\u5e2e\u52a9\u65b0\u836f\u7814\u53d1\u65e9\u671f\u786e\u5b9a\u4f34\u968f\u8bca\u65ad\u7684\u9700\u6c422016Principles for Codevelopment of an In Vitro Companion Diagnostic Device with a Therapeutic Product\u00a0\u5e2e\u52a9\u65b0\u836f\u548c\u4f34\u968f\u8bca\u65adIVD\u7814\u53d1\u7684\u5b9e\u7528\u6307\u53572018Developing and Labeling In Vitro Companion Diagnostic Devices for a Specific Group or Class of Oncology Therapeutic Products\u660e\u786e\u4f34\u968f\u8bca\u65ad\u4ea7\u54c1\u7684\u5206\u7c7b\uff0c\u786e\u5b9a\u5176\u8d28\u91cf\u7684\u610f\u4e49<\/div>\n
\u88681\uff1aFDA\u9646\u7eed\u51fa\u53f0\u4f34\u968f\u8bca\u65ad\u76f8\u5173\u7684\u89c4\u8303\u6587\u4ef6\uff08\u6765\u6e90\/FDA&\u57fa\u56e0\u6167\u7f16\u8bd1\uff09<\/div>\n
\u00a0<\/div>\n
\u00a0\u4e09\u3001NGS\u6280\u672f\u4f5c\u4e3a\u4f34\u968f\u8bca\u65ad\u7684\u8d8b\u52bf\u00a0\u00a0 \u00a0\u00a0\u00a0<\/div>\n
\u6839\u636eMarkets&Markets\u7684\u9884\u6d4b\uff0c\u52302024\u5e74\uff0c\u5168\u7403\u4f34\u968f\u8bca\u65ad\u5e02\u573a\u9884\u8ba1\u5c06\u4ece2019\u5e74\u768435\u4ebf\u7f8e\u5143\u589e\u957f\u523073\u4ebf\u7f8e\u5143\uff0c\u590d\u5408\u5e74\u589e\u957f\u7387\u4e3a15.7\uff05\u3002\u57fa\u56e0\u6167\u8ba4\u4e3a\u8fd9\u4e2a\u6570\u636e\u8fc7\u4e8e\u4fdd\u5b88\uff0c\u5ffd\u7565\u4e86\u836f\u7269\u7814\u53d1\u4e2d\u6210\u672c\u964d\u4f4e\u6536\u76ca\uff0c\u6b64\u662f\u540e\u8bdd\u3002<\/div>\n
\u00a0<\/div>\n
\u6cdb\u751f\u5b50\u57fa\u56e0\u544a\u8bc9\u57fa\u56e0\u6167\uff0c\u65e0\u8bba\u662f\u4f20\u7edf\u7684\u514d\u75ab\u7ec4\u5316\uff0cRT-PCR\u8bd5\u5242\u76d2\uff0c\u8fd8\u662f\u8fd1\u5e74\u6765\u65b0\u5174\u7684\u4e8c\u4ee3\u6d4b\u5e8f\u6216\u6570\u5b57PCR\u5e73\u53f0\uff0c\u90fd\u80fd\u591f\u4e3a\u75c5\u4eba\u63d0\u4f9b\u7528\u836f\u524d\u7684\u9776\u5411\u68c0\u6d4b\u548c\u6307\u5bfc\u3002\u5176\u4e2d\uff0cNGS\u65b9\u6cd5\u57fa\u4e8e\u5176\u9ad8\u901a\u91cf\u7684\u7279\u6027\u548c\u4ef7\u683c\u7684\u4e0d\u65ad\u964d\u4f4e\uff0c\u5728\u540c\u7b49\u5468\u671f\u548c\u6837\u54c1\u91cf\u7684\u524d\u63d0\u4e0b\uff0c\u53ef\u4ee5\u9ad8\u6548\u68c0\u6d4b\u591a\u79cd\u4e0d\u540c\u7684\u57fa\u56e0\u9776\u70b9\u3002\u57fa\u56e0\u6167\u8ba4\u4e3a\uff0c\u968f\u7740\u9ad8\u901a\u91cf\u6d4b\u5e8f\uff08NGS\uff09\u6280\u672f\u7684\u666e\u60e0\uff0c\u672a\u6765\u7684\u4f34\u968f\u8bca\u65ad\u5c06\u4ece\u76ee\u524d\u7684\u5c0fPanel\uff0c\u5feb\u901f\u62d3\u5c55\u5230\u5927Panel\u4ee5\u53ca\u5168\u57fa\u56e0\u7ec4\uff0c\u5728\u5168\u751f\u547d\u5468\u671f\u7ba1\u7406\u4e0a\u63d0\u524d\u5173\u53e3\u5230\u65b0\u751f\u513f\u9636\u6bb5\u3002<\/div>\n
\u00a0<\/div>\n
\u5728\u4ea7\u54c1\u5546\u4e1a\u5316\uff08\u4e5f\u662f\u6280\u672f\u666e\u60e0\u5316\uff09\u8fc7\u7a0b\u4e2d\uff0c\u7f8e\u56fd\u7684Foundation Medicine\uff08FMI\uff09\u3001MSK\u8d70\u5728\u524d\u5217\uff0c\u56fd\u5185\u7684\u827e\u5fb7\u751f\u7269\u3001\u71c3\u77f3\u533b\u5b66\u3001\u4e16\u548c\u57fa\u56e0\u3001\u8bfa\u79be\u81f4\u6e90\u3001\u534e\u5927\u57fa\u56e0\u7b49\u4e5f\u53d6\u5f97NMPA\u7684\u8d44\u8d28\u3002<\/div>\n
\u9996\u4e2a\u57fa\u4e8e\u9ad8\u901a\u91cf\u6d4b\u5e8f\uff08NGS\uff09\u7684\u4f34\u968f\u8bca\u65ad\u8bd5\u5242\u76d2\u8981\u8ffd\u6eaf\u52302016\u5e7412\u670819\u65e5\uff0cFMI\u516c\u53f8\u7684FoundationFocus CDxBRCA\u4ea7\u54c1\u83b7\u5f97FDA\u7684\u6279\u51c6\uff0c\u4e3b\u8981\u662f\u68c0\u6d4b\u5375\u5de2\u764c\u60a3\u8005\u7684BRCA\u57fa\u56e0\u6765\u5224\u65ad\u65b0\u836fRubraca\u662f\u5426\u53ef\u80fd\u6709\u6548\u3002\u6839\u636eClovis\u548cFMI\u4e24\u5bb6\u516c\u53f8\u7684\u5e74\u62a5\uff0c2019\u5e74Q2\u7684Rubraca \u7684\u51c0\u9500\u552e\u989d\u662f 3300\u4e07\u7f8e\u91d1\uff0c\u540c\u6bd4\u589e\u957f39%\u3002FMI\u5728\u88abRoche\u6536\u8d2d\u524d\u7684\u6700\u540e\u4e00\u6b21\u8d22\u62a5\uff082018\u5e74Q1\uff09\u663e\u793a\uff0c\u4e34\u5e8a\u68c0\u6d4b\u670d\u52a1\u8fbe21,861\u4eba\u6b21\uff0c\u540c\u6bd4\u589e\u957f57%\uff0cFoundationFocus CDx BRCA \u7684\u9500\u91cf\u4e3a48\u4eba\u6b21\uff0c\u6709\u5f88\u5927\u589e\u957f\u7a7a\u95f4\u3002<\/div>\n
\u00a0<\/div>\n
\u4e00\u5e74\u540e\u76842017\u5e7411\u6708\uff0c\u9996\u4e2a\u591a\u764c\u79cd\u591a\u57fa\u56e0\u68c0\u6d4b\u5e73\u53f0\u83b7FDA\u6279\u51c6\uff1aMSK-IMPACT\u8be6\u60c5<\/a>\uff09\u3002\u5b9e\u73b0\u4e86\u4ece\u836f\u7269\u7597\u6548\u76f8\u5173\u57fa\u56e0\u7684\u7279\u5f02\u53d8\u5f02\u4f4d\u70b9\u5230\u6574\u4e2apanel\uff08\u591a\u57fa\u56e0\u7ec4\u5408\uff09\u7684\u8de8\u8d8a\uff0c\u4e5f\u5f00\u521b\u4e86\u533b\u5b66\u548c\u5546\u4e1a\u5b9e\u9a8c\u5ba4\u5f00\u53d1\u7684\u57fa\u56e0\u68c0\u6d4b\u4ea7\u54c1\u7684\u6388\u6743\u5148\u4f8b\u3002\u7d27\u63a5\u7740\uff0cFMI\u7684FoundationOne CDx\u83b7FDA\u6279\u51c6\uff08\u8be6\u60c5<\/a>\uff09\uff0c\u8986\u76d6324\u4e2a\u57fa\u56e0\uff0c\u5f97\u5230FDA\u548cCMS\uff08\u533b\u7597\u4fdd\u9669\u548c\u533b\u7597\u8865\u52a9\u670d\u52a1\u4e2d\u5fc3\uff09\u5e73\u884c\u5ba1\u67e5\u8ba1\u5212\uff0c\u516d\u4e2a\u6708\u5feb\u901f\u83b7\u6279\u3002\u76ee\u524d\u5728\u4e09\u5927\u6d32\u768420\u591a\u4e2a\u56fd\u5bb6\u4e0a\u5e02\u3002<\/div>\n
\u00a0<\/div>\n
\u764c\u75c7\u8bca\u65ad\u516c\u53f8NeoGenomics\uff08Nasdq:NEO)\u00a0\u4eca\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u8425\u6536\u540c\u6bd4\u589e\u957f50%\uff0c\u622a\u6b622019\u5e746\u670830\u65e5\u7684\u6536\u5165\u8fbe\u52301.017\u4ebf\u7f8e\u5143\uff0cCEO Douglas VanOort\u8c08\u5230\uff0c\u4f34\u968f\u8bca\u65ad\u9886\u57df\u671f\u671b\u7a33\u5b9a\u589e\u957f\uff0c\u76ee\u524d\u670930\u4e2a\u9879\u76ee\u6b63\u5728\u8fdb\u884c\u4e2d\uff0c\u9884\u8ba12020\u5e74\u5728\u4e2d\u56fd\u6295\u5165\u5efa\u8bbe\u5b9e\u9a8c\u5ba4\u3002\u764c\u75c7\u57fa\u56e0\u68c0\u6d4b\u516c\u53f8Guardant Health (NASDAQ:GH) \u4e5f\u56e0\u4e3a\u9488\u5bf9\u751f\u7269\u5236\u836f\u5ba2\u6237\u7684\u4f34\u968f\u8bca\u65ad\u5f00\u53d1\uff0cQ2\u8425\u6536\u540c\u6bd4\u7ffb\u4e866\u500d\uff0c\u8fbe\u52304210\u4e07\u7f8e\u5143\u3002<\/div>\n
\u00a0<\/div>\n
\u6211\u56fd\u80bf\u7624\u57fa\u56e0\u4f34\u968f\u8bca\u65ad\u8bd5\u5242\u76d2\uff0c\u5728ctDNA\u65b9\u9762\uff0c\u4ee52018\u5e741\u6708\u7684\u827e\u5fb7\u751f\u7269\u7684Super-ARMS\u00ae EGFR\u5f00\u5148\u6cb3\uff0c\u7d27\u63a5\u77402018-2019\u5e74\uff0c\u5728NGS\u9886\u57df\u9646\u7eed\u5ba1\u6279\u4e86\u5305\u62ec\u71c3\u77f3\u533b\u5b66\u3001\u8bfa\u79be\u81f4\u6e90\u3001\u4e16\u548c\u57fa\u56e0\u3001\u827e\u5fb7\u751f\u7269\u548c\u534e\u5927\u57fa\u56e0\u4e94\u5bb6\u516c\u53f8\u7684NGS\u4f34\u968f\u8bca\u65ad\u8bd5\u5242\u76d2\uff0c\u5728\u5176\u4ed6\u56db\u5bb6\u5747\u805a\u7126\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u540c\u65f6\uff0c\u827e\u5fb7\u751f\u7269\u7387\u5148\u5b9e\u73b0\u8de8\u764c\u79cd\uff08\u7ed3\u76f4\u80a0\u764c\uff09\u7684NGS\u4f34\u968f\u8bca\u65ad\u3002<\/div>\n\n
\n
\"0?wx_fmt=png\"\/<\/figure><\/div>\n\n
\u88682\uff1a\u8fd1\u5e74\u5404\u56fd\u83b7\u6279\u7684\u4f34\u968f\u8bca\u65ad\u8bd5\u5242\u76d2\u4e0d\u5b8c\u5168\u7edf\u8ba1\uff08\u6765\u6e90\/\u57fa\u56e0\u6167\uff0c\u70b9\u51fb\u56fe\u7247\u653e\u5927\u66f4\u6e05\u6670\uff09<\/div>\n
\u00a0\u56db\u3001\u5c55\u671b\u672a\u6765\u00a0<\/div>\n
\u5c55\u671b\u672a\u6765\uff0c\u57fa\u4e8e\u57fa\u56e0\u6d4b\u5e8f\u3001\u514d\u75ab\u7ec4\u5316\u7b49\u6280\u672f\u7684\u4f34\u968f\u8bca\u65ad\u7684\u5e02\u573a\u89c4\u6a21\u6301\u7eed\u6269\u5927\uff0c\u540c\u65f6\u53cd\u54fa\u63a8\u52a8\u521b\u65b0\u836f\u7814\u53d1\uff0c\u5f62\u6210\u6b63\u5411\u56de\u8def\u3002\u4e3b\u8981\u539f\u56e0\u548c\u63a8\u52a8\u529b\u5305\u62ec\u4ee5\u4e0b\u51e0\u70b9\uff1a<\/div>\n\n
\n
\"RmFicvQBAkgBeyKFIVVqIqnoIzr0ttQ3CTLkcxLwJBIUqicdlSp8bAnSHktGKaEZHgnPTxIGCrDpT7mu8uhEgP1w\"\/<\/figure><\/div>\n\n
\u56fe4\uff1a\u82f1\u56fd\u751f\u7269\u94f6\u884c\uff08UK Biobank\uff09\u7814\u7a76\u7684\u751f\u7269\u6570\u636e\uff08\u6765\u6e90\/Nature)<\/div>\n
1. \u57fa\u7840\u7814\u7a76\uff1a\u5e7f\u4e49\u7684\u57fa\u56e0\u578b\u548c\u8868\u578b\u7684\u6301\u7eed\u53d1\u73b0\u548c\u8f6c\u5316<\/div>\n
\u57fa\u56e0\u578b\u548c\u8868\u578b\u7684\u7814\u7a76\u9010\u6e10\u8d8b\u5411\u5927\u6837\u672c\u961f\u5217\uff0c\u5f62\u6210\u751f\u7269\u6837\u672c\u5e93\uff08\u751f\u7269\u94f6\u884c\uff09\u3002<\/div>\n
2005\u5e74\u8d77\uff0c\u7531\u82f1\u56fd\u536b\u751f\u90e8\u8054\u5408Wellcome Trust\u7b49\u591a\u5bb6\u673a\u6784\u542f\u52a8\u7684\u82f1\u56fd\u751f\u7269\u94f6\u884c\uff08UK Biobank<\/a>\uff09\uff0c\u622a\u6b622010\u5e74\u5171\u62db\u52df\u548c\u83b7\u5f97\u8fd150\u4e07\u4eba\u7684\u751f\u7269\u6837\u672c\u6570\u636e\uff08\u56fe4\uff09\u3002\u81ea\u5f00\u653e\u6570\u636e\u8bbf\u95ee\u4ee5\u6765\uff0c\u8d85\u8fc78000\u4e2a\u83b7\u6279\u7684\u6ce8\u518c\u9879\u76ee\uff0c\u5728\u540c\u884c\u8bc4\u8bae\u671f\u520a\u4e0a\u53d1\u8868\u4e86\u8d85\u8fc7500\u7bc7\u6587\u7ae0\u3002\u4f8b\u5982\u5728\u4e00\u98798,248\u4f4d\u4e2a\u4f53\u6837\u672c\u7814\u7a76\u4e2d\uff0c\u79d1\u5b66\u5bb6\u786e\u5b9a\u4e863000\u591a\u79cd\u5927\u8111\u529f\u80fd\u548c\u7ed3\u6784\u6210\u50cf\u76f8\u5173\u8868\u578b\uff0c\u5e76\u8fdb\u884c\u4e86\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff0c\u786e\u5b9a\u90e8\u5206\u4e0e\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u76f8\u5173\u7684\u57fa\u56e0[10]\u3002UK Biobank\u4eca\u5e74\u83b7\u5f97\u5b89\u8fdb\u3001\u963f\u65af\u5229\u5eb7\u3001\u845b\u5170\u7d20\u53f2\u514b\u4ee5\u53ca\u5f3a\u751f\u56db\u5bb6\u836f\u4f01\u603b\u8ba1\u6295\u5165\u76841\u4ebf\u82f1\u9551\u3002<\/div>\n
\u00a0<\/div>\n
\u5728\u6211\u56fd\uff0c\u81ea2015\u5e74\u542f\u52a8\u7684\u201c\u4e2d\u56fd\u804b\u75c5\u57fa\u56e0\u7ec4\u8ba1\u5212\u201d\u30012016\u5e74\u542f\u52a8\u7684\u8986\u76d6\u8d85\u8fc760\u4e07\u4eba\u201c\u7cbe\u51c6\u533b\u5b66\u7814\u7a76\u201d\u91cd\u5927\u4e13\u9879\u30012018\u5e74\u542f\u52a8\u7684\u201c\u4e2d\u56fd\u5341\u4e07\u4eba\u57fa\u56e0\u7ec4\u8ba1\u5212\u201d\u7b49\u4eba\u7fa4\u961f\u5217\u7814\u7a76\uff0c\u5c06\u6301\u7eed\u53d1\u73b0\u548c\u5e7f\u4e49\u7684\u57fa\u56e0\u578b\u548c\u8868\u578b\u7684\u5173\u8054\uff08\u5305\u62ec\u5fae\u751f\u7269\u7ec4\u3001\u86cb\u767d\u7ec4\u7b49\uff09\u3002\u57282020-2030\u5e74\u671f\u95f4\uff0c\u8fd9\u4e9b\u5efa\u7acb\u5728\u4e2d\u56fd\u591a\u6837\u5316\u4eba\u7fa4\u57fa\u7840\u4e0a\u7684\u751f\u7269\u6837\u672c\uff0c\u5c06\u4e3a\u836f\u7269\u57fa\u56e0\u9776\u70b9\u53d1\u73b0\u3001\u4f34\u968f\u8bca\u65ad\u53ca\u65b0\u836f\u7814\u53d1\u63d0\u4f9b\u4e30\u5bcc\u7684\u7d20\u6750\u3002<\/div>\n
\u00a0<\/div>\n
2. \u521b\u65b0\u836f\u653f\u7b56\u63a8\u52a8\uff1a\u5916\u4f01\u836f\u53ca\u5916\u8d44\u5f00\u653e\u548c\u5ba1\u6279\u653f\u7b56<\/div>\n
\u9664\u4e86\u964d\u4f4e\u6297\u764c\u836f\u5173\u7a0e\u5916\uff0c\u5728 2017 \u5e74\u65b0\u7248\u76ee\u5f55\u4ee5\u53ca\u540e\u7eed\u7684\u8c08\u5224\u76ee\u5f55\u4e2d\uff0c\u6211\u4eec\u53ef\u4ee5\u770b\u5230\u5409\u975e\u66ff\u5c3c\uff0c\u57c3\u514b\u66ff\u5c3c\u7b4917\u79cd\u6297\u764c\u836f\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u3002\u57fa\u4e8e\u4f34\u968f\u8bca\u65ad\u7684\u7cbe\u51c6\u7528\u836f\uff08\u7528\u836f\u6307\u5bfc\uff09\u5728\u63d0\u9ad8\u60a3\u8005\u7cbe\u51c6\u6cbb\u7597\u6548\u7387\u540c\u65f6\uff0c\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u901a\u8fc7\u5408\u7406\u7528\u836f\u6765\u964d\u4f4e\u533b\u4fdd\u5f00\u652f\u3002<\/div>\n
\u00a0<\/div>\n
\u6b64\u5916\uff0c2019\u5e7410\u6708\uff0c\u4f5c\u4e3a\u7531\u7f8e\u56fd\u60e0\u666e\u516c\u53f8\u6218\u7565\u91cd\u7ec4\u5206\u7acb\u800c\u6210\u7684\u8de8\u56fd\u516c\u53f8\u5b89\u6377\u4f26(NYSE: A)\u00a0\u83b7\u5f97\u6211\u56fd\u9996\u4e2a\u6279\u51c6\u7684PD-L1\u4f34\u968f\u8bca\u65ad\u8bd5\u5242\u76d2\uff0c\u5728\u60a3\u8005\u670d\u7528\u9ed8\u6c99\u4e1c\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u836f\u7269KEYTRUDA\u65f6\u8fdb\u884c\u7528\u836f\u6307\u5bfc\u3002\u53ef\u4ee5\u770b\u51fa\u6211\u56fd\u5728\u521b\u65b0\u836f\u9886\u57df\u7684\u5f00\u653e\u51b3\u5fc3\u3002<\/div>\n
\u00a0<\/div>\n
\u56fd\u4ea7\u836f\u4f01\u4e5f\u5728\u52a0\u5feb\u6b65\u4f10\u3002\u56fd\u4ea7PD-1\/PD-L1\u4e0a\u5e02\u7684\u836f\u4f01\u541b\u5b9e\u751f\u7269\uff08HK.01877\uff09\u3001\u4fe1\u8fbe\u751f\u7269\uff08HK.01801\uff09\u3001\u6052\u745e\u533b\u836f\uff08SH.600276)\u4ee5\u53ca\u8fdb\u5165II\u671f\u548cIII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5eb7\u5b81\u6770\u745e\u3001\u57fa\u77f3\u836f\u4e1a\u7b49\u4f01\u4e1a\u7684\u65b0\u836f\u5728\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u65b9\u9762\u7684\u7a81\u7834\uff0c\u90fd\u5c06\u5e26\u6765\u4f34\u968f\u8bca\u65ad\u7684\u9700\u6c42\u548c\u5408\u4f5c\u3002<\/div>\n
\u00a0<\/div>\n
\u4e0e\u6b64\u540c\u65f6\uff0c\u521a\u521a\u767b\u9646\u79d1\u521b\u677f\u7684\u5fae\u82af\u751f\u7269\uff08SH.688321\uff09\u5ba3\u5e03\u548cPre-IPO\u9636\u6bb5\u7684\u57fa\u56e0\u4f01\u4e1a\u8bfa\u79be\u81f4\u6e90\u5408\u4f5c\uff0c\u57fa\u4e8e\u8bfa\u79be\u81f4\u6e90\u7684\u4f34\u968f\u8bca\u65ad\u57fa\u56e0\u68c0\u6d4b\u65b9\u6cd5\uff0c\u6765\u9884\u6d4b\u897f\u5965\u7f57\u5c3c\u9488\u5bf9\u5c0f\u7ec6\u80de\u80ba\u764c\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u75c5\u4eba\u7b5b\u9009\u5206\u7ec4\u4ee5\u53ca\u836f\u6548\u3002<\/div>\n
\u56fd\u5185\u57fa\u56e0\u548c\u65b0\u836f\u7684\u8054\u59fb\u6545\u4e8b\u521a\u521a\u5f00\u59cb\u3002<\/div>\n
\u00a0<\/div>\n
3. \u4ea7\u4e1a\u534f\u540c\uff1a\u57fa\u56e0\u4f01\u4e1a\u548c\u836f\u5382\u6df1\u5165\u5408\u4f5c<\/div>\n
\u800c\u5bf9\u5916\u6d77\u5916\u800c\u8a00\uff0c\u57fa\u56e0\u548c\u65b0\u836f\u7684\u8054\u59fb\u5df2\u6e10\u5165\u4f73\u5883\u3002<\/div>\n
2019\u5e744\u670812\u65e5\uff0c\u5f3a\u751f\u65d7\u4e0b\u7684\u5384\u8fbe\u66ff\u5c3cerdafitinib (Balversa)\u4f5c\u4e3a\u9488\u5bf9FGFR\u6539\u53d8\u7684\u8180\u80f1\u764c\u60a3\u8005\u7684\u7b2c\u4e00\u79cd\u9776\u5411\u836f\u83b7\u5f97FDA\u6279\u51c6\u3002\u540c\u65e5\uff0cFDA\u4e5f\u6279\u51c6\u4e86\u5df2\u6279\u51c6Qiagen\u65d7\u4e0b\u9488\u5bf9\u5384\u8fbe\u66ff\u5c3c\u7684\u4f34\u968f\u8bca\u65ad\u8bd5\u5242\u76d2\u3002<\/div>\n
\u00a0<\/div>\n
\u66f4\u591a\u57fa\u56e0\u4f01\u4e1a\u4e0e\u836f\u4f01\u7684\u6df1\u5165\u5408\u4f5c\uff0c\u53c2\u89c1\u88683:<\/div>\n
#\u5408\u4f5c\u673a\u6784\u5408\u4f5c\u5f00\u53d11Cellgen & Genomics Testing Cooperative\u514d\u75ab\u6cbb\u7597\u4f34\u968f\u8bca\u65ad2Qiagen &\u00a0LabCorp\u00a0\u80ba\u764c\u3001\u4e73\u817a\u764c\u3001\u5927\u80a0\u764c\u3001\u8180\u80f1\u764c\u4ee5\u53ca\u6cdb\u764c\u79cd\u7684NGS\/qPCR\u4f34\u968f\u8bca\u65ad3Qiagen & Inovio PharmaceuticalsHPV\u5bab\u9888\u53d1\u80b2\u4e0d\u826f\u7684\u514d\u75ab\u6cbb\u7597\u4f34\u968f\u8bca\u65ad4Resolution Bioscience & Janssen\u00a0\u6cbb\u7597\u524d\u5217\u817a\u764c\u836fNiraparib\u7684\u4f34\u968f\u8bca\u65ad5Prometheus & Takeda\u00a0\u708e\u75c7\u6027\u80a0\u75c5(IBD\uff09\u7684\u4f34\u968f\u8bca\u65ad6Thermo Fisher Scientific & Eli LillyRET\u6fc0\u9176\u6291\u5236\u5242LOXO-292\u7684\u4f34\u968f\u8bca\u65ad<\/p>\n
\u88683\uff1a\u57fa\u56e0\u4f01\u4e1a\u548c\u836f\u4f01\u7684\u5408\u4f5c\u4e3e\u4f8b\uff08\u6765\u6e90\/\u57fa\u56e0\u6167\u6574\u7406\uff09<\/div>\n
\u00a0<\/div>\n
FDA\u7684\u533b\u7597\u5668\u68b0\u4e0e\u8bbe\u5907\u4e2d\u5fc3\u516c\u5f00\u8868\u793a\uff0c\u5c06\u7ee7\u7eed\u9f13\u52b1\u57fa\u56e0\u8bca\u65ad\u4f01\u4e1a\u4e0e\u836f\u4f01\u5408\u4f5c\u201c\u836f\u7269-\u4f34\u968f\u8bca\u65ad\u201d\uff0c \u8fd9\u5bf9\u4e8e\u4e25\u91cd\u7684\u5371\u53ca\u751f\u547d\u7684\u3001\u65b0\u578b\u75be\u75c5\u7684\u65e9\u671f\u6cbb\u7597\u548c\u7528\u836f\u6307\u5bfc\u975e\u5e38\u6709\u610f\u4e49\u3002<\/div>\n
\u00a0<\/div>\n
4. \u652f\u4ed8\u56de\u8def<\/div>\n
\u652f\u4ed8\u80fd\u529b\u548c\u6210\u672c\u662f\u4e00\u4e2a\u4ea7\u54c1\u666e\u60e0\u5e94\u7528\u7684\u53cc\u9762\u6838\u5fc3\u3002\u5bf9\u4e8e\u4f34\u968f\u8bca\u65ad\uff0c\u5409\u56e0\u52a0\u7684\u674e\u6e05\u6797\u603b\u76d1\u544a\u8bc9\u57fa\u56e0\u6167\uff0c\u76ee\u524d\u652f\u4ed8\u4e3b\u4f53\u65b92-3\u5e74\u5185\u8fd8\u662f\u4ee5\u75c5\u4eba\u4e3a\u4e3b\uff0c\u4f46\u53ef\u4ee5\u770b\u5230\u672a\u6765\u4f1a\u8fdb\u5165\u533b\u4fdd\u7684\u8d8b\u52bf\uff0c\u76ee\u524d\u5317\u4eac\u5df2\u5c06\u764c\u75c7\u57fa\u56e0\u68c0\u6d4b\u7eb3\u5165\u533b\u4fdd\u3002\u5728\u521b\u65b0\u652f\u4ed8\u6a21\u5f0f\u4e0a\uff0c\u672a\u6765\u836f\u5382\u7684\u7814\u53d1\u8d39\u7528\u53ef\u80fd\u4f1a\u5206\u62c5\u90e8\u5206\uff0c\u4f46\u6bd4\u4f8b\u5e94\u8be5\u4e0d\u4f1a\u7279\u522b\u591a\u3002<\/div>\n
\u00a0<\/div>\n
5.\u00a0\u6570\u636e\u53cc\u5411\u6d41\u901a<\/div>\n
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\uff08\u9664\u4e86\u4f34\u968f\u8bca\u65ad\u7ed3\u5408\u70b9\uff0c\u5728\u521b\u65b0\u836f\u7a81\u56f4\u4e2d\uff0c\u57fa\u56e0\u5982\u4f55\u63d0\u9ad8\u5148\u5bfc\u5316\u5408\u7269\u7b5b\u9009\u7684\u6548\u7387\uff0c\u8bf7\u5173\u6ce8\u4e0b\u6587\u5206\u89e3\u3002\u6b22\u8fce\u7559\u8a00\u8ba8\u8bba\u3002\uff09<\/div>\n
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1\uff09CSCO\u77ad\u671b | \u4e3b\u4f1a\u573a\u62a5\u544a\u3001\u80ba\u764c\u53ca\u521b\u65b0\u836f\u4e13\u573a\u7b14\u8bb0<\/a><\/div>\n
2\uff09Science\uff1aA New Look at Clinical Success Rates<\/div>\n
3\uff09GenomeWeb<\/div>\n
4\uff09\u5f13\u5b5f\u6625 \u96e8\u4f1e\u4e0e\u7bee\u5b50\u7684\u6311\u6218\uff1a\u7cbe\u51c6\u533b\u5b66\u4e0e\u7cd6\u5c3f\u75c5\uff0cHIT\u4e13\u5bb6\u7f51<\/div>\n
5\uff09\u5434\u4e00\u9f99 \u7cbe\u51c6\u764c\u533b\u5b66\uff1a\u8d70\u5411\u672a\u6765\u7684\u8def\u3002\u5faa\u8bc1\u533b\u5b66<\/div>\n
6\uff09List of Cleared or Approved Companion Diagnostic Devices (In Vitro and Imaging Tools<\/div>\n
7\uff09Herceptin for HER2-positive breast cancer improves long-term survival<\/div>\n
8\uff09Foundation Medicine Announces 2018 First Quarter Results and Recent Highlights<\/div>\n
9) Clare Bycroft, Colin Freeman, Desislava Petkova et al. The UK Biobank resource with deep phenotyping and genomic data\uff0cNature volume 562, pages203\u2013209 (2018)<\/div>\n
10) Lloyd T. Elliott, Kevin Sharp, Fidel Alfaro-Almagro et al. Genome-wide association studies of brain imaging phenotypes in UK Biobank, Nature volume 562, pages210\u2013216 (2018)<\/div>\n
11\uff09http:\/\/www.100pei.com\/5143.html<\/div>\n
12\uff09\u5357\u65b9\u65e5\u62a5\uff1a\u4e73\u817a\u764c\u9776\u5411\u836f\u5e15\u6377\u7279\u5b9a\u4ef7\u6709\u671b\u201c\u5168\u7403\u6700\u4f4e\u201d<\/div>\n
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