{"id":9193,"date":"2019-11-01T01:21:46","date_gmt":"2019-10-31T17:21:46","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&#038;mid=100011673&#038;idx=1&#038;sn=73cac3e5b3a00198ee512c4b099b25c1&#038;chksm=6b715c2e5c06d538f570a12817405a206fb55eaebd0f70e0d9592dc5ae3cb3431eb3eee4a8cb#rd"},"modified":"2026-04-02T12:26:42","modified_gmt":"2026-04-02T04:26:42","slug":"9954101","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2019\/11\/01\/9954101\/","title":{"rendered":"\u72ec\u5bb6\u4e13\u8bbf\u4e2d\u56fd\u5b66\u8005\u300aCell\u300b\u9996\u53d1\u8de8\u7ec4\u7ec7\u5355\u7ec6\u80de\u6c34\u5e73\u7684\u809d\u764c\u514d\u75ab\u56fe\u8c31"},"content":{"rendered":"<p><!-- wechat_content_hash: c6eb87603750e923 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class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDAtMXBIibUm3Kp50Ebiak83dUVDjPTINs4rzHkCVdeZsKqA0R2ux0fhXGxGWrRxa9hJ8ykFeVgKvOA.jpeg\" alt=\"RmFicvQBAkgDAtMXBIibUm3Kp50Ebiak83dUVDjPTINs4rzHkCVdeZsKqA0R2ux0fhXGxGWrRxa9hJ8ykFeVgKvOA\"\/><\/figure><\/div>\n\n<div style=\"text-align: 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Medicine\u300b\u4e0a\u53d1\u5e03\u7ed3\u76f4\u80a0\u764c\u548c\u80ba\u764c\u5355\u7ec6\u80de\u56fe\u8c31\uff0c\u8fd9\u6b21\u8bfe\u9898\u6709\u4ec0\u4e48\u91cd\u5927\u53d1\u73b0\u5462\uff1f\u53ef\u4ee5\u901a\u4fd7\u5730\u3001\u6982\u62ec\u6027\u5730\u5206\u4eab\u4e00\u4e0b\u5417\uff1f\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>\u3010\u5f20\u6cfd\u6c11\u6559\u6388\u3011\u672c\u9879\u76ee\u4ecd\u7136\u9009\u62e9\u4e86\u809d\u764c\u4f5c\u4e3a\u7814\u7a76\u5bf9\u8c61\uff0c\u56e0\u4e3a\u809d\u7ec6\u80de\u764c\u662f\u4e16\u754c\u8303\u56f4\u5185\u6b7b\u4ea1\u7387\u6392\u540d\u7b2c\u4e09\u7684\u764c\u75c7\uff0c\u5176\u4e2d\u4e2d\u56fd\u7684\u809d\u764c\u53d1\u75c5\u7387\u5c45\u4e16\u754c\u4e4b\u9996\u3002HBV\u7684\u6162\u6027\u611f\u67d3\u662f\u4e2d\u56fd\u809d\u7ec6\u80de\u764c\u53d1\u751f\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u5176\u611f\u67d3\u5bfc\u81f4\u80bf\u7624\u5fae\u73af\u5883\u5e38\u4f34\u968f\u6162\u6027\u708e\u75c7\u3002\u514d\u75ab\u9003\u9038\u88ab\u8ba4\u4e3a\u662f\u764c\u75c7\u53d1\u5c55\u7684\u6807\u5fd7\u4e4b\u4e00\uff0c\u76ee\u524d\u7814\u7a76\u8868\u660e\uff0c\u80bf\u7624\u5b58\u5728\u591a\u79cd\u514d\u75ab\u9003\u9038\u673a\u5236\uff0c\u7a81\u51fa\u4e86\u7814\u7a76\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u4e0d\u540c\u514d\u75ab\u7ec6\u80de\u72b6\u6001\u7684\u91cd\u8981\u6027\u3002<\/div>\n<div>\u76f8\u6bd4\u6211\u4eec\u5b9e\u9a8c\u5ba4\u4e4b\u524d\u5728\u4e0d\u540c\u764c\u79cd\u4e2d\u8fdb\u884c\u7684T\u7ec6\u80de\u7684\u7814\u7a76\uff0c\u672c\u9879\u76ee\u540c\u65f6\u5173\u6ce8\u4e86T\u7ec6\u80de\u4e4b\u5916\u7684\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\uff0c\u5e76\u63a2\u7a76\u4e86\u514d\u75ab\u7ec6\u80de\u5728\u4e0d\u540c\u7ec4\u7ec7\u4e4b\u95f4\u7684\u8054\u7cfb\u4ee5\u53ca\u4e0d\u540c\u7c7b\u578b\u514d\u75ab\u7ec6\u80de\u4e4b\u95f4\u7684\u6f5c\u5728\u76f8\u4e92\u4f5c\u7528\u3002\u6bd4\u5982\uff0c\u8179\u6c34\u662f\u809d\u764c\u60a3\u8005\u5e38\u89c1\u7684\u75c5\u7406\u73b0\u8c61\uff0c\u5176\u4ea7\u751f\u4e0e\u809d\u764c\u9884\u540e\u4e0d\u826f\u6709\u5173\uff0c\u7136\u800c\u8179\u6c34\u4e2d\u7684\u514d\u75ab\u7ec6\u80de\u7ec4\u6210\u53ca\u5176\u4e0e\u809d\u764c\u7684\u8054\u7cfb\u5c1a\u4e0d\u6e05\u695a\u3002<\/div>\n<div>\u6211\u4eec\u901a\u8fc7\u524d\u6cbf\u7684\u751f\u7269\u4fe1\u606f\u5b66\u5206\u6790\u65b9\u6cd5\uff0c\u5efa\u7acb\u4e86\u8179\u6c34\u4e2d\u514d\u75ab\u7ec6\u80de\u4e0e\u5176\u4ed6\u7ec4\u7ec7\u4e2d\u7ec6\u80de\u7684\u8054\u7cfb\uff0c\u4e3b\u8981\u53d1\u73b0\u8179\u6c34\u4e2d\u7684\u6dcb\u5df4\u7ec6\u80de\u548c\u9ad3\u7cfb\u7ec6\u80de\u6765\u6e90\u660e\u663e\u4e0d\u540c\uff0c\u6dcb\u5df4\u7ec6\u80de\u4e0e\u5916\u5468\u8840\u6765\u6e90\u7684\u7ec6\u80de\u6709\u660e\u663e\u7684\u76f8\u4f3c\u6027\uff0c\u800c\u9ad3\u7cfb\u7ec6\u80de\u4e3b\u8981\u548c\u80bf\u7624\u7ec4\u7ec7\u6765\u6e90\u7684\u7ec6\u80de\u7c7b\u4f3c\u3002\u540c\u65f6\uff0c\u6811\u7a81\u72b6\u7ec6\u80de\uff08DC\uff09\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u8d77\u5230\u91cd\u8981\u7684\u8c03\u63a7\u4f5c\u7528\u3002\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684DC\uff0c\u4f20\u7edf\u4e0a\u5206\u4e3acDC1\u548ccDC2\uff0c\u800c\u6211\u4eec\u57fa\u4e8e\u6d4b\u5e8f\u6570\u636e\u9274\u5b9a\u51fa\u4e00\u7fa4\u7279\u70b9\u7a81\u51fa\u7684LAMP3+ DC\u3002\u5b83\u4eec\u53ef\u4ece\u80bf\u7624\u8fc1\u79fb\u5230\u5916\u5468\u6dcb\u5df4\u7ed3\uff0c\u8868\u8fbe\u591a\u79cd\u514d\u75ab\u914d\u4f53\u57fa\u56e0\uff0c\u5e76\u5177\u6709\u4e0e\u591a\u79cdT\u6dcb\u5df4\u7ec6\u80de\u7c7b\u578b\u76f8\u4e92\u4f5c\u7528\u7684\u6f5c\u529b\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u4e09\u3001\u521b\u65b0\u7684\u8bfe\u9898\u8bbe\u8ba1\u601d\u8def<\/div>\n<div>1\uff09\u5728\u6837\u672c\u6536\u96c6\u4e0a\uff0c\u9664\u4e86\u5e38\u89c4\u7684\u764c\u7ec4\u7ec7\u3001\u764c\u65c1\u7ec4\u7ec7\u3001\u6dcb\u5df4\u7ed3\u3001\u5916\u5468\u8840\uff0c\u6536\u96c6\u4e86\u75c5\u7406\u7ec4\u7ec7\u5728\u5185\u7684\u591a\u7ec4\u7ec7\u4f4d\u70b9\u7684\u6536\u96c6\u3002\u00a0<\/div>\n<div>2\uff09\u7ed3\u5408\u4e24\u79cd\u5355\u7ec6\u80de\u6d4b\u5e8f\u6280\u672f\u5e73\u53f0\uff1aSMART-seq2\u548c10x Genomics Chromium 3\u2019\uff0c\u5e76\u6574\u5408\u4e24\u79cd\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\u6570\u636e\u8fdb\u884c\u751f\u7269\u4fe1\u606f\u5206\u6790\u3002\u00a0<\/div>\n<div>3\uff09\u57fa\u4e8e\u524d\u6cbf\u7684\u751f\u7269\u4fe1\u606f\u5b66\u5206\u6790\u65b9\u6cd5RNA velocity\u548c\u57fa\u4e8e\u7ebf\u7c92\u4f53\u7a81\u53d8\u6784\u5efa\u8fdb\u5316\u6811\u3002\u5e76\u901a\u8fc7CRISPR\u6280\u672f\u5728THP-1\u8bf1\u5bfc\u7684\u5de8\u566c\u7ec6\u80de\u7cfb\u4e2d\u8fdb\u884c\u57fa\u56e0\u6572\u9664\u548c\u529f\u80fd\u9a8c\u8bc1\u5b9e\u9a8c\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDAtMXBIibUm3Kp50Ebiak83dgiczbyOOk0rTicibE83wp7Nll2aSj3sOWPtG6pu9RhdmAtOn9ricIgXBHg.jpeg\" alt=\"RmFicvQBAkgDAtMXBIibUm3Kp50Ebiak83dgiczbyOOk0rTicibE83wp7Nll2aSj3sOWPtG6pu9RhdmAtOn9ricIgXBHg\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe3\uff1a\u672c\u8bfe\u9898\u603b\u4f53\u8bbe\u8ba1\uff0c\u6765\u6e90\/\u300aCell\u300b<\/div>\n<div>\u3010\u57fa\u56e0\u6167\u3011\u8bfe\u9898\u603b\u4f53\u8bbe\u8ba1\u7684\u601d\u8def\u662f\u600e\u6837\u7684\u5462\uff1f<\/div>\n<div>\u3010\u6587\u7ae0\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u5f20\u542f\u660e\u3011\u672c\u6b21\u8bfe\u9898\u8bbe\u8ba1\u5728\u5b9e\u9a8c\u548c\u6570\u636e\u5206\u6790\u65b9\u9762\u90fd\u6709\u6240\u7a81\u7834\u3002\u4ece\u6d4b\u5e8f\u5e73\u53f0\u7684\u9009\u62e9\u6765\u8bf4\uff0c\u6211\u4eec\u4e24\u79cd\u5404\u5177\u4f18\u52bf\u7684\u6d4b\u5e8f\u6280\u672f10x 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Genomics Chromium 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\u7ee7\u4e0a\u6b21\u5408\u4f5c\u4e00\u5bb6\u836f\u4f01\u540e\uff0c\u6211\u4eec\u770b\u5230\u8fd9\u6b21\u5317\u4eac\u5927\u5b66\u751f\u7269\u533b\u5b66\u524d\u6cbf\u521b\u65b0\u4e2d\u5fc3\u3001\u751f\u547d\u79d1\u5b66\u5b66\u9662\u3001\u5317\u4eac\u672a\u6765\u57fa\u56e0\u8bca\u65ad\u9ad8\u7cbe\u5c16\u521b\u65b0\u4e2d\u5fc3\u548c\u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u4e16\u7eaa\u575b\u533b\u9662\u3001\u5fb7\u56fd\u836f\u4f01\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u516c\u53f8\u8054\u5408\u53c2\u4e0e\u8bfe\u9898\uff0c\u53ef\u5426\u8c08\u8c08\u836f\u4f01\u5728\u5176\u4e2d\u7684\u89d2\u8272\uff0c\u4ee5\u53ca\u672a\u6765\u7cfb\u5217\u7814\u7a76\u7684\u8f6c\u5316\u65b9\u5411\uff1f\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>\u3010\u5f20\u6cfd\u6c11\u6559\u6388\u3011\u8fd9\u662f\u6211\u4eec\u9996\u6b21\u4e0e\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u516c\u53f8\u8fdb\u884c\u5408\u4f5c\uff0c\u662f\u4e00\u6b21\u975e\u5e38\u6210\u529f\u7684\u5408\u4f5c\u3002\u5728\u5b9e\u9a8c\u548c\u6570\u636e\u5206\u6790\u8fc7\u7a0b\u4e2d\uff0c\u6211\u4eec\u901a\u8fc7\u8ba8\u8bba\u4ea4\u6d41\uff0c\u5171\u540c\u63a2\u7d22\u8bfe\u9898\u65b9\u5411\u3002\u7279\u522b\u662f\u5230\u9879\u76ee\u540e\u671f\uff0c\u9700\u8981\u5bf9\u5206\u6790\u7ed3\u679c\u8fdb\u884c\u751f\u7269\u5b66\u9a8c\u8bc1\u65f6\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u516c\u53f8\u7684\u591a\u4f4d\u79d1\u5b66\u5bb6\u548c\u8bfe\u9898\u7ec4\u90fd\u53c2\u4e0e\u5230\u5176\u4e2d\uff0c\u5145\u5206\u53d1\u6325\u4ed6\u4eec\u7684\u4f18\u52bf\uff0c\u5b8c\u6210\u4e86\u91cd\u8981\u7684\u5b9e\u9a8c\u9a8c\u8bc1\uff0c\u52a0\u5f3a\u4e86\u672c\u8bfe\u9898\u5728\u514d\u75ab\u9886\u57df\u53ca\u5e94\u7528\u8f6c\u5316\u65b9\u9762\u7684\u7814\u7a76\uff0c\u4ece\u800c\u5347\u534e\u4e86\u6574\u4e2a\u8bfe\u9898\u7684\u610f\u4e49\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u5728\u5408\u4f5c\u8fc7\u7a0b\u4e2d\uff0c\u6211\u4eec\u4e3a\u4e86\u9075\u5faa\u4e2d\u56fd\u9057\u4f20\u529e\u5173\u4e8e\u4e2d\u56fd\u9057\u4f20\u4fe1\u606f\u4fdd\u62a4\u7684\u65b0\u89c4\u5b9a\uff0c\u907f\u514d\u4e86\u4e0e\u56fd\u5916\u5408\u4f5c\u65b9\u5206\u4eab\u4efb\u4f55\u4e2d\u56fd\u75c5\u4eba\u7684\u4e34\u5e8a\u4fe1\u606f\u4ee5\u53ca\u9057\u4f20\u4fe1\u606f\uff0c\u800c\u5728\u79d1\u5b66\u601d\u8def\u548c\u5355\u4e2a\u57fa\u56e0\u529f\u80fd\u9a8c\u8bc1\u65b9\u9762\u4e0e\u5176\u8fbe\u5230\u4e86\u6709\u6548\u7684\u5408\u4f5c\u3002\u6211\u8ba4\u4e3a\u6211\u4eec\u5728\u5145\u5206\u4fdd\u62a4\u4e2d\u56fd\u9057\u4f20\u4fe1\u606f\u7684\u57fa\u7840\u4e0a\uff0c\u901a\u8fc7\u591a\u65b9\u5bc6\u5207\u8054\u7cfb\uff0c\u8c03\u52a8\u548c\u6574\u5408\u5404\u65b9\u8d44\u6e90\uff0c\u5b8c\u6210\u4e86\u672c\u9879\u7814\u7a76\u5de5\u4f5c\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u7531\u4e8e\u6211\u81ea\u5df1\u52a0\u5165\u5317\u5927\u4e4b\u524d\u4e5f\u662f\u957f\u671f\u5728\u836f\u4f01\u5de5\u4f5c\uff0c\u6211\u6df1\u6df1\u5730\u611f\u5230\u5728\u836f\u4f01\u5de5\u4f5c\u7684\u79d1\u5b66\u5bb6\u5bf9\u6700\u6025\u9700\u7684\u79d1\u5b66\u8f6c\u5316\u95ee\u9898\u6709\u7740\u66f4\u76f4\u63a5\u7684\u5224\u65ad\u548c\u628a\u63e1\uff0c\u80fd\u591f\u5e2e\u52a9\u6211\u4eec\u6293\u5230\u95ee\u9898\u7684\u91cd\u70b9\u3002\u4e0d\u8fc7\uff0c\u6211\u4eec\u9009\u62e9\u7684\u8bfe\u9898\u90fd\u662f\u7531\u5317\u5927\u4e3b\u5bfc\u7684\uff0c\u77e5\u8bc6\u4ea7\u6743\u4e5f\u5728\u4e2d\u65b9\u3002\u56e0\u4e3a\u6211\u4eec\u5f97\u5230\u7684\u79d1\u5b66\u8fdb\u5c55\u90fd\u662f\u201c\u524d\u7ade\u4e89\u201d(pre-competitive),\u6211\u4eec\u7684\u53d1\u73b0\u53ef\u4ee5\u53d7\u76ca\u4e8e\u56fd\u5185\u5916\u6240\u6709\u76f8\u5173\u7684\u5236\u836f\u4f01\u4e1a\u3002\u5f53\u7136\uff0c\u6211\u4eec\u7684\u53d1\u73b0\u662f\u76f8\u5bf9\u57fa\u7840\u7684\uff0c\u79bb\u9776\u70b9\u53d1\u73b0\u548c\u5236\u836f\u8fd8\u6709\u5f88\u8fdc\u7684\u8ddd\u79bb\uff0c\u5e0c\u671b\u6211\u4eec\u7684\u53d1\u73b0\u80fd\u591f\u5bf9\u56fd\u5185\u5916\u76f8\u5173\u836f\u4f01\u7406\u89e3\u548c\u63a2\u7d22\u80bf\u7624\u514d\u75ab\u836f\u7269\u8d77\u5230\u79ef\u6781\u4f5c\u7528\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u3010\u6587\u7ae0\u5171\u540c\u901a\u8baf\u4f5c\u8005\u5218\u5eb7\u535a\u58eb\uff08\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u516c\u53f8\u4e3b\u4efb\u79d1\u5b66\u5bb6\uff09\u3011\u5f20\u6559\u6388\u4e0e\u6211\u4eec\u7684\u672c\u6b21\u5408\u4f5c\u53ef\u8c13\u662f\u4e00\u6b21\u9ad8\u8d28\u91cf\u5408\u4f5c\u7684\u8303\u4f8b\u3002\u7279\u522b\u662f\u5728\u540e\u671f\u5b9e\u9a8c\u9a8c\u8bc1\u671f\u95f4\uff0c\u6211\u4eec\u9891\u7e41\u7684\u8fdb\u884c\u8ba8\u8bba\u4ea4\u6d41\uff0c\u5145\u5206\u6316\u6398\u540e\u7eed\u503c\u5f97\u6df1\u5165\u63a2\u7a76\u7684\u65b9\u5411\uff0c\u5305\u62ec\u91cd\u8981\u7684\u7ec6\u80de\u7c7b\u578b\u3001\u6f5c\u5728\u7684\u8c03\u63a7\u56e0\u5b50\u7b49\u3002\u591a\u65b9\u4ea4\u6d41\u4e0d\u4ec5\u80fd\u8ba9\u6211\u4eec\u8f83\u597d\u5730\u5e94\u5bf9\u8bfe\u9898\u4e2d\u51fa\u73b0\u7684\u95ee\u9898\u548c\u56f0\u96be\uff0c\u4e5f\u4e3a\u6211\u4eec\u540e\u7eed\u5bf9\u65b0\u7684\u8c03\u63a7\u56e0\u5b50\u8fdb\u884c\u8ffd\u8e2a\u548c\u8ddf\u8fdb\u63d0\u4f9b\u4e86\u4fbf\u5229\u3002\u6211\u4eec\u4e0e\u5f20\u6559\u6388\u4e5f\u7ee7\u7eed\u8fdb\u884c\u5408\u4f5c\uff0c\u5e0c\u671b\u5c06\u6765\u53ef\u4ee5\u548c\u5927\u5bb6\u5206\u4eab\u6210\u679c\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u3010\u57fa\u56e0\u6167\u3011 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