{"id":9171,"date":"2019-12-29T12:00:14","date_gmt":"2019-12-29T04:00:14","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&mid=100012277&idx=1&sn=4ebe22fe0f5aa58474064ef1a138a04d&chksm=6b7142425c06cb547dc629cd2287077aed8b1e4fbd295acd1e8e4355ea4ae2669e587c0bacdf#rd"},"modified":"2026-04-02T12:21:13","modified_gmt":"2026-04-02T04:21:13","slug":"534850","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2019\/12\/29\/534850\/","title":{"rendered":"\u57fa\u56e0\u7b80\u62a5GeneMail | \u534e\u5927\u65d7\u4e0b\u611f\u67d3\u5b50\u516c\u53f8\u62df\u878d\u8d445\u4ebf\u5143\uff0cmiRNA\u9996\u6b21\u7eb3\u5165\u809d\u764c\u8bca\u7597\u89c4\u8303"},"content":{"rendered":"

<\/p>\n

\u57fa\u56e0\u6167<\/div>\n
GeneMail<\/div>\n
\u6570\u5b57\u751f\u547d\u5065\u5eb7\u4ea7\u4e1a\u7b80\u62a5<\/div>\n
\u3010\u57fa\u56e0\u7b80\u62a5GeneMail\u3011No.86\u671f<\/div>\n
\u25a0 \u653f\u7b56\uff1a\u536b\u5065\u59d4\u9996\u6b21\u5c06miRNA\u7eb3\u5165\u809d\u764c\u8bca\u7597\u89c4\u8303<\/div>\n
\u25a0 \u6280\u672f\uff1a\u7eb3\u7c73\u5b54\u6d4b\u5e8f\u6280\u672f\u5feb\u901f\u9274\u5b9a\u975e\u6d32\u732a\u761f\u75c5\u6bd2<\/div>\n
\u25a0 \u5e94\u7528\uff1a\u9996\u4e2a\u6210\u4eba\u57c3\u535a\u62c9\u75ab\u82d7\u83b7FDA\u6279\u51c6\u4e0a\u5e02<\/div>\n
\u25a0 \u4ea7\u4e1a\uff1a\u534e\u5927\u65d7\u4e0b\u611f\u67d3\u5b50\u516c\u53f8\u62df\u878d\u8d445\u4ebf\u5143<\/div>\n
* \u65b0\u95fb\u6295\u9012\u90ae\u7bb1\uff1ainfo@genonet.cn\uff0c\u8bf7\u4ee5\u5355\u4f4d\u90ae\u7bb1\u53d1\u9001\u3002<\/div>\n\n
\n
\"RmFicvQBAkgCAowXISjUiaV52g0u0HI2EMs1hIeCYDxJnGicAPnYxE8v35LXe4hW1eMUCECEz23XnzeP6jw5M3veA\"\/<\/figure><\/div>\n\n<\/div>\n
\u56fe\uff1a\u80bf\u7624\uff08\u6765\u6e90\/\u7f51\u7edc\uff09<\/div>\n
<\/div>\n
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\u653f\u7b56<\/div>\n\n
1. \u56fd\u5bb6\u536b\u5065\u59d4\u9996\u6b21\u5c06miRNA\u68c0\u6d4b\u7eb3\u5165\u809d\u764c\u8bca\u7597\u89c4\u8303<\/div>\n
12\u670817\u65e5\uff0c\u56fd\u5bb6\u536b\u5065\u59d4\u300a\u539f\u53d1\u6027\u809d\u764c\u8bca\u7597\u89c4\u8303\uff082019\u5e74\u7248\uff09\u300b\u53d1\u5e03\u4f1a\u4e8e\u7b2c\u5341\u4e03\u5c4a\u5168\u56fd\u809d\u764c\u5b66\u672f\u4f1a\u8bae\u671f\u95f4\u53ec\u5f00\uff0c7\u79cd\u5fae\u5c0f\u6838\u7cd6\u6838\u9178(microRNA)\u809d\u764c\u57fa\u56e0\u68c0\u6d4b\u88ab\u9996\u6b21\u7eb3\u5165\u3002\uff08\u987f\u6167\u533b\u7597\uff09<\/div>\n
\u00a0<\/div>\n
2.\u300a\u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u836f\u54c1\u7ba1\u7406\u6cd5\u300b\u6b63\u5f0f\u5b9e\u65bd<\/div>\n
12\u670821\u65e5\uff0c\u56fd\u5bb6\u836f\u76d1\u5c40\u53d1\u5e03\u5173\u4e8e\u8d2f\u5f7b\u5b9e\u65bd\u65b0\u4fee\u8ba2\u7684\u300a\u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u836f\u54c1\u7ba1\u7406\u6cd5\u300b\u6709\u5173\u4e8b\u9879\u7684\u516c\u544a\u3002\uff08\u4e2d\u56fd\u836f\u95fb\uff09\u70b9\u51fb\u67e5\u770b\u8be6\u60c5<\/a><\/div>\n
\u00a0<\/div>\n
3. \u56fd\u5bb6\u836f\u76d1\u5c40\u53d1\u5e03\u533b\u7597\u5668\u68b0\u9644\u6761\u4ef6\u6279\u51c6\u4e0a\u5e02\u6307\u5bfc\u539f\u5219<\/div>\n
12\u670820\u65e5\uff0c\u4e3a\u8d2f\u5f7b\u843d\u5b9e\u4e2d\u5171\u4e2d\u592e\u529e\u516c\u5385\u3001\u56fd\u52a1\u9662\u529e\u516c\u5385\u300a\u5173\u4e8e\u6df1\u5316\u5ba1\u8bc4\u5ba1\u6279\u5236\u5ea6\u6539\u9769\u9f13\u52b1\u836f\u54c1\u533b\u7597\u5668\u68b0\u521b\u65b0\u7684\u610f\u89c1\u300b\uff0c\u89e3\u51b3\u4e25\u91cd\u5371\u53ca\u751f\u547d\u75be\u75c5\u7684\u4e34\u5e8a\u6cbb\u7597\u9700\u6c42\uff0c\u52a0\u5feb\u76f8\u5173\u533b\u7597\u5668\u68b0\u7684\u5ba1\u8bc4\u5ba1\u6279\uff0c\u53d1\u5e03\u4e86\u56fd\u5bb6\u836f\u76d1\u5c40\u7ec4\u7ec7\u5236\u5b9a\u4e86\u533b\u7597\u5668\u68b0\u9644\u6761\u4ef6\u6279\u51c6\u4e0a\u5e02\u6307\u5bfc\u539f\u5219\u3002\uff08\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff09<\/div>\n
\u00a0<\/div>\n
4. \u540c\u6d4e\u5927\u5b66\u56fd\u5bb6\u5e72\u7ec6\u80de\u8f6c\u5316\u8d44\u6e90\u5e93\u6b63\u5f0f\u6210\u7acb\u00a0<\/div>\n
12\u67086\u65e5\uff0c\u56fd\u5bb6\u5e72\u7ec6\u80de\u8f6c\u5316\u8d44\u6e90\u5e93\uff0c\u4e8e\u4e0a\u6d77\u63a8\u8fdb\u79d1\u6280\u521b\u65b0\u4e2d\u5fc3\u5efa\u8bbe\u529e\u516c\u5ba4\u7b2c\u5341\u4e00\u6b21\u5168\u4f53\u4f1a\u8bae\u4e0a\u6b63\u5f0f\u63ed\u724c\uff0c\u8be5\u8d44\u6e90\u5e93\u4f9d\u6258\u540c\u6d4e\u5927\u5b66\u751f\u547d\u79d1\u5b66\u4e0e\u6280\u672f\u5b66\u9662\u53ca\u9644\u5c5e\u4e1c\u65b9\u533b\u9662\u5efa\u8bbe\u3002\uff08\u5e72\u7ec6\u80de\uff09<\/div>\n
\u00a0<\/div>\n
5. Illumina\u6536\u8d2dPacBio\u88ab\u7f8e\u56fd\u8054\u90a6\u8d38\u6613\u59d4\u5458\u4f1a\u963b\u6b62<\/div>\n
\u7f8e\u56fd\u8054\u90a6\u8d38\u6613\u59d4\u5458\u4f1a\uff08FTC\uff09\u5ba3\u5e03\uff0c\u5df2\u6279\u51c6\u4e00\u9879\u884c\u52a8\u4ee5\u963b\u6b62Illumina12\u4ebf\u7f8e\u5143\u6536\u8d2dPacific Biosciences\u7684\u4ea4\u6613\u3002\u6b64\u524d\uff0cIllumina\u88ab\u6295\u8bc9\u8bd5\u56fe\u4ee5\u6536\u8d2dPacBio\u4f5c\u4e3a\u65b0\u751f\u7684\u7ade\u4e89\u5a01\u80c1\uff0c\u6765\u975e\u6cd5\u7ef4\u6301\u5176NGS\u8bbe\u5907\u5728\u7f8e\u56fd\u5e02\u573a\u7684\u5784\u65ad\u5730\u4f4d\u3002\u884c\u653f\u5ba1\u5224\u5b9a\u4e8e2020\u5e748\u670818\u65e5\u5f00\u59cb\u3002\uff08Genomeweb\uff09<\/div>\n\n
\u6280\u672f<\/div>\n\n
<\/div>\n
6. \u5229\u7528\u7eb3\u7c73\u5b54\u6d4b\u5e8f\u6280\u672f\u5feb\u901f\u9274\u5b9a\u975e\u6d32\u732a\u761f\u75c5\u6bd2\u57fa\u56e0\u7ec4\u00a0<\/div>\n
\u8fd1\u65e5\uff0c\u7f8e\u56fd\u519c\u4e1a\u90e8\u4e0b\u5c5e\u7684\u7814\u7a76\u673a\u6784\u5728Journal of Clinical Microbiology \u4e0a\u53d1\u8868\u4e86\u9488\u5bf9\u975e\u6d32\u732a\u761f\u75c5\u6bd2\u7684\u9996\u4e2a\u7ed3\u5408\u6837\u54c1\u5bcc\u96c6\u3001\u7eb3\u7c73\u5b54MinION\u6d4b\u5e8f\u6280\u672f\u3001\u4ee5\u53ca\u65b0\u578b\u5feb\u901f\u5206\u6790\u8f6f\u4ef6\u7684\u62a5\u544a\uff0c\u5b9e\u73b0\u5bf9\u8be5\u75c5\u6bd2\u57fa\u56e0\u7ec4\u5e8f\u5217\u7684\u771f\u6b63\u5b9e\u65f6\u68c0\u6d4b\u3002(BioArt)\u00a0<\/div>\n
<\/div>\n
<\/div>\n
7. \u4e16\u754c\u9996\u4f8b\u201c\u732a\u7334\u5d4c\u5408\u4f53\u201d\u8bde\u751f\u4e2d\u56fd\u00a0<\/div>\n
\n\n
\n
\"RmFicvQBAkgBgjhd2JiaZ7Wic1XXBYic6icvWFiaBxhM9df80vibcTfqsKmU36NndS3Mw7DTfd9x0dtQiaqgVdgmHdWiamQ\"\/<\/figure><\/div>\n\n
\u56fe\uff1a\u9996\u4f8b \u201c\u732a\u7334\u5d4c\u5408\u4f53\u201d \u6d3b\u4ea7\uff08\u6765\u6e90\/\u300a\u65b0\u79d1\u5b66\u5bb6\u300b\uff09<\/div>\n
\u4e2d\u56fd\u79d1\u5b66\u9662\u52a8\u7269\u7814\u7a76\u6240\u5e72\u7ec6\u80de\u4e0e\u751f\u6b96\u751f\u7269\u5b66\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u7684\u6d77\u68e0\u535a\u58eb\uff0c\u674e\u4f1f\u7814\u7a76\u5458\u548c\u4e2d\u56fd\u79d1\u5b66\u9662\u9662\u58eb\u5468\u742a\uff0c\u628a\u7334\u5b50\u7684\u80da\u80ce\u5e72\u7ec6\u80de\u6ce8\u5c04\u5230\u4e86\u732a\u7684\u80da\u80ce\u4e2d\uff0c\u4ea7\u751f\u4e862\u53ea\u201c\u732a\u7334\u5d4c\u5408\u4f53\u201d\u3002\u7814\u7a76\u7ed3\u679c\u4e8e2019\u5e7411\u670828\u65e5\u53d1\u8868Protein \uff06 Cell \u4e0a\u3002\uff08DeepTech\u6df1\u79d1\u6280\uff09<\/div>\n
\u00a0<\/div>\n
8. CRISPR\u57fa\u56e0\u7f16\u8f91\u7684\u5c0f\u732a3.0\u95ee\u4e16\uff0c\u8fc4\u4eca\u6700\u9002\u4eba\u4f53\u5668\u5b98\u79fb\u690d\u00a0<\/div>\n
\u65e5\u524d\uff0c\u7531\u6768\u7490\u83e1\u535a\u58eb\u8054\u5408\u521b\u7acb\u7684\u751f\u7269\u79d1\u6280\u516c\u53f8\u542f\u51fd\u751f\u7269\u4e0e\u7f8e\u56fdeGenesis\u516c\u53f8\u8054\u5408\u516c\u5e03\uff0c\u5341\u51e0\u5934\u7ecf\u8fc7CRISPR\u57fa\u56e0\u7f16\u8f91\u7684\u5c0f\u732a3.0\u6210\u529f\u95ee\u4e16\uff0c\u8fd9\u662f\u8fc4\u4eca\u6700\u9002\u5408\u4eba\u4f53\u79fb\u690d\u7684\u57fa\u56e0\u7f16\u8f91\u5c0f\u732a\u3002\u6210\u679c\u4e8e12\u670817\u65e5\u5728bioRxiv\u53d1\u8868\u4e86\u9898\u4e3a\u201cExtensive Mammalian Germline Genome Engineering \u201d\u7684\u8bba\u6587\u9884\u5370\u672c\u3002\uff08\u5b66\u672f\u7ecf\u7eac\uff09<\/div>\n
\u00a0<\/div>\n
9. Nature Plants\uff1a\u534e\u5927\u7814\u7a76\u6210\u679c\u63ed\u793a\u65e9\u671f\u7eff\u8272\u690d\u7269\u4ece\u6c34\u751f\u5230\u9646\u5730\u7684\u9002\u5e94\u673a\u5236\u00a0<\/div>\n
12\u670816\u65e5\uff0cNature Plants\u5728\u7ebf\u53d1\u8868\u4e86\u6765\u81ea\u6df1\u5733\u534e\u5927\u751f\u547d\u79d1\u5b66\u7814\u7a76\u9662\u8054\u5408\u5fb7\u56fd\u3001\u4e39\u9ea6\u4e0e\u52a0\u62ff\u5927\u7b49\u56e2\u961f\u7684\u9898\u4e3a\u201cGenomes of early-diverging streptophyte algae shed light on plant terrestrialization\u00a0\u201d\u7684\u7814\u7a76\u8bba\u6587\uff0c\u63ed\u793a\u4e86\u65e9\u671f\u7eff\u8272\u690d\u7269\u4ece\u6c34\u751f\u5230\u9646\u5730\u7684\u9002\u5e94\u673a\u5236\u3002\uff08BGI\u534e\u5927\uff09<\/div>\n
\u00a0<\/div>\n
10. Nature\u516c\u5e032019\u5e74\u5ea6\u5341\u5927\u79d1\u5b66\u8fdb\u5c55\uff0c\u534e\u4eba\u5b66\u8005\u4e3b\u5bfc\/\u53c2\u4e0e4\u9879\u00a0<\/div>\n
\u7f8e\u56fd\u65f6\u95f412\u670813\u65e5\uff0cNature\u6b63\u5f0f\u53d1\u5e03Nature2019\u5e74\u5ea6\u5341\u4f73\u3002\u5176\u4e2d\uff0c\u590d\u65e6\u5927\u5b66\u3001\u4e2d\u79d1\u9662\u4e0a\u6d77\u6709\u673a\u6240\uff0cBroad\u7814\u7a76\u6240\u5218\u5982\u8c26\uff08David R. Liu\uff09\u5404\u8d21\u732e\u4e00\u7bc7\uff0c\u53f0\u5927\u533b\u9662\u3001\u5e7f\u897f\u5987\u5e7c\u4fdd\u5065\u9662\u5171\u540c\u53c2\u4e0e\u4e00\u7bc7\uff0c\u5171\u8ba14\u7bc7\u3002\uff08\u79d1\u7814\u5927\u5320\uff09<\/div>\n
\u00a0<\/div>\n

11. Mol Plant\uff1a\u9996\u6b21\u63ed\u793a\u5bc4\u751f\u690d\u7269\u83df\u4e1d\u5b50\u4e0e\u5bc4\u4e3b\u95f4\u5927\u89c4\u6a21\u86cb\u767d\u8d28\u4ea4\u6d41\u00a0<\/p>\n

12\u67086\u65e5\uff0cMolecular Plant\u5728\u7ebf\u53d1\u8868\u4e86\u4e2d\u56fd\u79d1\u5b66\u9662\u6606\u660e\u690d\u7269\u7814\u7a76\u6240\u5434\u5efa\u5f3a\u8bfe\u9898\u7ec4\u9898\u4e3a\u201cExtensive inter-plant protein transfer between Cuscuta parasites and their host plants \u201d\u7684\u7814\u7a76\u8bba\u6587\uff0c\u62a5\u9053\u4e86\u5bc4\u751f\u690d\u7269\u83df\u4e1d\u5b50\u4e0e\u5bc4\u4e3b\u95f4\u5927\u89c4\u6a21\u7684\u86cb\u767d\u8d28\u4ea4\u6d41\u3002\uff08Mol Plant\u690d\u7269\u79d1\u5b66 \uff09<\/p>\n

 <\/p>\n

12. Nature Methods\uff1a\u962e\u73cf\/\u674e\u6052\u5408\u4f5c\u5f00\u53d1\u7b2c\u4e09\u4ee3\u6d4b\u5e8f\u6570\u636e\u7ec4\u88c5\u7b97\u6cd5\u00a0<\/p>\n

12\u67089\u65e5\uff0c\u4e2d\u56fd\u519c\u79d1\u9662\u519c\u4e1a\u57fa\u56e0\u7ec4\u7814\u7a76\u6240\u7684\u962e\u73cf\u535a\u58eb\u4e0e\u7f8e\u56fd\u54c8\u4f5b\u533b\u5b66\u9662\u7684\u674e\u6052\u535a\u58eb\uff0c\u5408\u4f5c\u5f00\u53d1\u4e86\u7b2c\u4e09\u4ee3\u6d4b\u5e8f\u6570\u636e\u7ec4\u88c5\u7b97\u6cd5\u2014\u2014wtdbg2\uff0c\u76f8\u6bd4\u4e8e\u957f\u8bfb\u957f\u7ec4\u88c5\u7b97\u6cd5Flye\uff0cwtdbg2\u5c06\u5206\u6790\u901f\u5ea6\u63d0\u5347\u4e865\u500d\uff0c\u9996\u6b21\u5c06\u6570\u636e\u5206\u6790\u65f6\u95f4\u964d\u4f4e\u5230\u5c11\u4e8e\u6570\u636e\u4ea7\u51fa\u65f6\u95f4\u3002\u6210\u679c\u5728Nature Biotechnology\u4e0a\u4ee5\u201cFast and accurate long-read assembly with wtdbg2 \u201d\u53d1\u8868\u3002\uff08BioArt\uff09<\/div>\n\n
\u5e94\u7528<\/div>\n\n
13. \u9996\u4e2a\u6210\u4eba\u57c3\u535a\u62c9\u75ab\u82d7\u83b7\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\u00a0<\/div>\n
\u8fd1\u65e5\uff0c FDA\u6279\u51c6\u9ed8\u6c99\u4e1c\uff08MSD\uff09\u516c\u53f8\u7684\u57c3\u535a\u62c9\u75ab\u82d7Ervebo(\u4e00\u79cd\u5355\u5242\u91cf\u6ce8\u5c04)\u4e0a\u5e02\uff0c\u8fd9\u662fFDA\u6279\u51c6\u7684\u9996\u4e2a\u9884\u9632\u57c3\u535a\u62c9\u75c5\u6bd2\u75c5\u7684\u9884\u9632\u6027\u75ab\u82d7\u3002\u53ef\u7528\u4e8e\u9884\u963218\u5c81\u4ee5\u4e0a\u7684\u624e\u4f0a\u5c14\u578b\u57c3\u535a\u62c9\u75c5\u6bd2\uff08\u751f\u7269\u63a2\u7d22\uff09\u3002\u00a0<\/div>\n
\u00a0<\/div>\n
14. \u56fd\u5bb6\u836f\u76d1\u5c40\uff1a\u6279\u51c6\u9996\u4e2aPD-L1\u5355\u6297Imfinzi\u4e0a\u5e02\u7533\u8bf7\u00a0<\/div>\n
12\u67089\u65e5\uff0c\u56fd\u5bb6\u836f\u76d1\u5c40\u5b98\u7f51\u663e\u793a\uff0c\u963f\u65af\u5229\u5eb7\u7684PD-L1\u5355\u6297Imfinzi\uff08durvalumab, \u5ea6\u4f10\u5229\u5c24\u5355\u6297\u6ce8\u5c04\u6db2\uff0c\u4e2d\u6587\u5546\u54c1\u540d\uff1a\u82f1\u98de\u51e1\uff0c\u7b80\u79f0I\u836f\uff09\u7684\u4e0a\u5e02\u7533\u8bf7\uff08JXSS1800040\/41\uff09\u83b7\u5f97\u6279\u51c6\uff0c\u53ef\u7528\u4e8e\u6cbb\u7597\u540c\u6b65\u653e\u5316\u7597\u540e\u672a\u8fdb\u5c55\u7684\u4e0d\u53ef\u5207\u9664III\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3002\uff08\u533b\u836f\u9b54\u65b9Plus\uff09\u00a0<\/div>\n
\u00a0<\/div>\n
15. FDA\u4eca\u65e5\u52a0\u901f\u6279\u51c6DMD\u521b\u65b0\u7597\u6cd5\u00a0<\/div>\n
12\u670813\u65e5\uff0c FDA\u5ba3\u5e03\uff0c\u52a0\u901f\u6279\u51c6Sarepta Therapeutics\u7684Vyondys 53\uff08golodirsen\uff09\u4e0a\u5e02\uff0c\u53ef\u7528\u4e8e\u6cbb\u7597\u4f7f\u7528\u5916\u663e\u5b5053\u8df3\u8dc3\uff08exon 53 skipping\uff09\u6cbb\u7597\u7684\u675c\u5174\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\uff08DMD\uff09\u60a3\u8005\u3002\uff08\u836f\u660e\u5eb7\u5fb7\uff09<\/div>\n
\u00a0<\/div>\n
16. \u5168\u7403\u6700\u5168\u9762\u7684\u963f\u8054\u914b\u56fd\u5bb6\u57fa\u56e0\u7ec4\u8ba1\u5212\u00a0<\/div>\n
\u963f\u8054\u914b\u5f53\u5730\u65f6\u95f412\u670810\u65e5\uff0c\u963f\u8054\u914b\u9996\u90fd\u963f\u5e03\u624e\u6bd4\u536b\u751f\u5c40\u5c40\u957f\u963f\u535c\u675c\u62c9\u00b7\u54c8\u7c73\u5fb7\u6b63\u5f0f\u5ba3\u5e03\uff0c\u542f\u52a8\u5168\u7403\u6700\u5168\u9762\u7684\u5168\u6c11\u57fa\u56e0\u7ec4\u8ba1\u5212\u2014\u2014\u201c\u963f\u8054\u914b\u5168\u6c11\u57fa\u56e0\u7ec4\u8ba1\u5212\u201d\uff0c\u76ee\u6807\u662f\u8fd0\u7528\u5927\u89c4\u6a21\u4eba\u7fa4\u57fa\u56e0\u7ec4\u6570\u636e\uff0c\u4e3a\u963f\u8054\u914b\u4eba\u6c11\u5efa\u7acb\u53ef\u9884\u6d4b\u3001\u53ef\u9884\u9632\u548c\u4e2a\u6027\u5316\u6cbb\u7597\u7684\u5168\u6c11\u533b\u7597\u536b\u751f\u4f53\u7cfb\u3002\uff08\u57fa\u56e0\u6167\uff09\u00a0<\/div>\n
\u00a0<\/div>\n
17. \u5343\u79cd\u52a8\u690d\u7269\u591a\u7ec4\u5b66\u7814\u7a76\u8ba1\u5212\u6b63\u5f0f\u542f\u52a8\u00a0<\/div>\n
\u7b2c\u4e00\u5c4a\u5168\u56fd\u4f5c\u7269\u79d1\u5b66\u524d\u6cbf\uff08\u6d77\u53e3\uff09\u8bba\u575b\u4e8e2019\u5e7412\u67085\u65e5-8\u65e5\u5728\u6d77\u5357\u6d77\u53e3\u53ec\u5f00\uff0c\u534e\u5927\u57fa\u56e0\u643a\u624b\u8fc8\u7ef4\u4ee3\u8c22\u3001SCIEX \u548cAgilent\uff0c\u6b63\u5f0f\u542f\u52a8\u201c\u5343\u79cd\u52a8\u690d\u7269\u591a\u7ec4\u5b66\u7814\u7a76\u8ba1\u5212\u201d\uff081000 LIBRARY PLAN\uff09\u3002\uff08\u534e\u5927\u79d1\u6280BGITech\uff09<\/div>\n\n
\u4ea7\u4e1a<\/div>\n\n
18. \u534e\u5927\u65d7\u4e0b\u611f\u67d3\u5b50\u516c\u53f8\u62df\u5f15\u5165\u6295\u8d44\u8fd15\u4ebf\u5143<\/div>\n
12\u670827\u65e5\uff0c\u534e\u5927\u57fa\u56e0\u53d1\u5e03\u300a\u5173\u4e8e\u8f6c\u8ba9\u63a7\u80a1\u5b50\u516c\u53f8\u90e8\u5206\u80a1\u6743\u53ca\u653e\u5f03\u589e\u8d44\u7684\u4f18\u5148\u8ba4\u8d2d\u6743\u66a8\u5173\u8054\u4ea4\u6613\u516c\u544a\u300b\uff0c\u63a7\u80a1\u5b50\u516c\u53f8\u6df1\u5733\u534e\u5927\u56e0\u6e90\u533b\u836f\u79d1\u6280\u6709\u9650\u516c\u53f8\uff0c\u62df\u4ee5\u589e\u8d44\u53ca\u63a7\u80a1\u80a1\u4e1c\u8f6c\u8ba9\u80a1\u6743\u7684\u65b9\u5f0f\u5f15\u5165\u591a\u5bb6\u4e13\u4e1a\u6295\u8d44\u673a\u6784\uff0c\u4ee5\u52a0\u5feb\u611f\u67d3\u9632\u63a7\u4e1a\u52a1\u7684\u6301\u7eed\u53d1\u5c55\uff0c\u7d2f\u8ba1\u5c06\u878d\u8d44\u8fd15\u4ebf\u5143\u3002\uff08\u4e2d\u56fd\u7f51\u8d22\u7ecf\uff09<\/div>\n
\u00a0<\/div>\n
19.\u00a0\u4e0a\u6d77\u7ec6\u80de\u6cbb\u7597\u96c6\u56e2\uff0c\u5b8c\u62109.25\u4ebf\u5143C\u8f6e\u878d\u8d44\u00a0<\/div>\n
12\u670818\u65e5\uff0c\u81f4\u529b\u4e8e\u6253\u9020\u7ec6\u80de\u5065\u5eb7\u7efc\u5408\u4f53\u7684\u5e73\u53f0\u7684\u4e0a\u6d77\u7ec6\u80de\u6cbb\u7597\u96c6\u56e2\u6709\u9650\u516c\u53f8\uff0c\u5ba3\u5e03\u5b8c\u62109.25\u4ebf\u5143\u7684C\u8f6e\u878d\u8d44\uff0c\u662f\u56fd\u5185\u7ec6\u80de\u6cbb\u7597\u884c\u4e1a\u76ee\u524d\u5b8c\u6210\u7684\u89c4\u6a21\u6700\u5927\u7684\u4e00\u6b21\u878d\u8d44\u3002\u672c\u8f6e\u6295\u8d44\u592a\u4fdd\u4eba\u5bff\u3001\u6d77\u5c14\u8d44\u672c\u548c\u5174\u4e1a\u56fd\u4fe1\u8d44\u7ba1\u8054\u5408\u9886\u6295\uff0c\u541b\u8054\u8d44\u672c\u3001\u5b89\u4ead\u5b9e\u4e1a\u3001\u5b81\u6ce2\u5706\u6c47\u7b49\u591a\u5bb6\u8ddf\u6295\u3002\uff08\u4e0a\u6d77\u7ec6\u80de\u6cbb\u7597\u5de5\u7a0b\u6280\u672f\u7814\u7a76\u4e2d\u5fc3\uff09\u00a0<\/div>\n
\u00a0<\/div>\n
20. \u5357\u4eac\u4e16\u548c\u57fa\u56e0\uff0c\u5b8c\u62108\u4ebf\u5143D\u8f6e\u878d\u8d44<\/div>\n
12\u670824\u65e5\uff0c\u4e16\u548c\u57fa\u56e0\u751f\u7269\u6280\u672f\u6709\u9650\u516c\u53f8\u5ba3\u5e03\uff0c\u5b8c\u62108\u4ebf\u5143\u7684D\u8f6e\u878d\u8d44\u3002\u672c\u8f6e\u6295\u8d44\u7531\u56fd\u65b0\u63a7\u80a1\u9886\u6295\uff0c\u793c\u6765\u4e9a\u6d32\u57fa\u91d1\u3001\u5efa\u53d1\u65b0\u5174\u6295\u8d44\u3001\u6613\u65b9\u8fbe\u3001\u8f6f\u94f6\u4e2d\u56fd\u8d44\u672c\u3001\u745e\u534e\u63a7\u80a1\u3001\u5357\u4eac\u6c5f\u5317\u65b0\u533a\u3001\u6717\u739b\u5cf0\u3001\u5929\u52e4\u541b\u6cfd\u3001\u534e\u6cf0\u745e\u5408\u533b\u7597\u4ea7\u4e1a\u57fa\u91d1\u8ddf\u6295\u3002\uff08\u5357\u4eac\u751f\u7269\u533b\u836f\u8c37\uff09<\/div>\n
\u00a0<\/div>\n
21.\u00a0\u6df1\u5733\u57fa\u56e0\u5b9d\uff0c\u5b8c\u6210\u8fd1\u4ebf\u5143A\u8f6e\u878d\u8d44\u00a0<\/div>\n
2019\u5e7410\u6708\uff0c\u81f4\u529b\u4e8e\u6d88\u8d39\u7ea7\u57fa\u56e0\u68c0\u6d4b\u7684\u57fa\u56e0\u5b9d\uff0c\u5b8c\u6210\u8fd1\u4ebf\u5143A\u8f6e\u878d\u8d44\uff0c\u672c\u8f6e\u6295\u8d44\u7531\u5927\u94b2\u8d44\u672c\u9886\u6295\u3002\u57fa\u56e0\u5b9d\u65e9\u524d\u5df2\u83b73600\u4e07\u5143\u5929\u4f7f\u8f6e\u878d\u8d44\uff0c\u6295\u8d44\u65b9\u4e3a\u4e0a\u5e02\u516c\u53f8\u8fde\u9501\u836f\u623f\u5927\u53c2\u6797\u3002\uff08\u4eca\u65e5\u5934\u6761\uff09<\/div>\n
\u00a0<\/div>\n
22. \u5317\u4eac\u5fae\u5ca9\u533b\u5b66\uff0c\u5b8c\u6210\u6570\u5343\u4e07\u5929\u4f7f\u8f6e\u878d\u8d44\u00a0<\/div>\n
\u8fd1\u65e5\uff0c\u4e13\u6ce8\u4e8e\u4e34\u5e8a\u611f\u67d3\u75c5\u539f\u5fae\u751f\u7269\u68c0\u6d4b\u7684\u5fae\u5ca9\u533b\u5b66\u79d1\u6280\uff08\u5317\u4eac\uff09\u6709\u9650\u516c\u53f8\uff0c\u5ba3\u5e03\u5b8c\u6210\u6570\u5343\u4e07\u5143\u5929\u4f7f\u8f6e\u878d\u8d44\uff0c\u672c\u8f6e\u6295\u8d44\u7531\u5e42\u65b9\u8d44\u672c\u72ec\u5bb6\u9886\u6295\u3002\uff08\u52a8\u8109\u7f51\uff09<\/div>\n
\u00a0<\/div>\n
23. \u7f57\u6c0f48\u4ebf\u7f8e\u5143\u6536\u8d2d\u57fa\u56e0\u6cbb\u7597\u516c\u53f8Spark Therapeutics\u00a0<\/div>\n
\u8fd1\u65e5\uff0c\u5386\u65f610\u4e2a\u6708\uff0c\u745e\u58eb\u5236\u836f\u5de8\u5934\u7f57\u6c0f(Roche)\uff0c\u5b8c\u6210\u4e8648\u4ebf\u7f8e\u5143\u6536\u8d2d\u57fa\u56e0\u6cbb\u7597\u516c\u53f8Spark Therapeutics\u7684\u4ea4\u6613\uff0c\u5c06\u7f8e\u56fdFDA\u6279\u51c6\u7684\u9996\u4e2a\u57fa\u56e0\u7597\u6cd5Luxturna(\u6cbb\u7597\u7f55\u89c1\u773c\u79d1\u75be\u75c5)\u548c\u51e0\u6b3e\u4e34\u5e8a\u9636\u6bb5\u8840\u53cb\u75c5\u57fa\u56e0\u7597\u6cd5\u4e00\u5e76\u6536\u5165\u56ca\u4e2d\u3002\u00a0\uff08\u533b\u9ea6\u5ba2\uff09<\/div>\n
\u00a0<\/div>\n
24.\u00a0\u4e0a\u6d77\u51ef\u8d5b\u751f\u7269\u7533\u8bf7\u79d1\u521b\u677f\u4e0a\u5e02\u00a0<\/div>\n
12\u670810\u65e5\uff0c\u57fa\u4e8e\u5408\u6210\u751f\u7269\u5b66\u7b49\u5b66\u79d1\u5229\u7528\u751f\u7269\u5236\u9020\u6280\u672f\uff0c\u7814\u53d1\u3001\u751f\u4ea7\u53ca\u9500\u552e\u65b0\u578b\u751f\u7269\u6750\u6599\u7684\u4e0a\u6d77\u51ef\u8d5b\u751f\u7269\u6280\u672f\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff0c\u63d0\u4ea4\u4e86\u79d1\u521b\u677f\u4e0a\u5e02\u62db\u80a1\u4e66\uff0c\u672c\u6b21\u878d\u8d4446.99\u4ebf\u5143\u3002\uff08\u52a8\u8109\u7f51\uff09\u00a0<\/div>\n
\u00a0<\/div>\n
25. \u8f89\u745e\u5411FDA\u9012\u4ea4Braftovi\u4e0a\u5e02\u7533\u8bf7<\/div>\n
\u00a012\u670819\u65e5\uff0c\u8f89\u745e\u5236\u836f\u6709\u9650\u516c\u53f8\u5ba3\u5e03\uff0c FDA\u5df2\u63a5\u53d7\u5176Braftovi(encorafenib)\u4e0eErbitux(\u897f\u59a5\u6614\u5355\u6297)\u53cc\u8054\u7597\u6cd5(Braftovi Doublet)\u7684\u8865\u5145\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7(sNDA)\uff0c\u5e76\u6388\u4e88\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c\u3002\uff08\u5373\u523b\u8981\u95fb\uff09<\/div>\n
\u00a0<\/div>\n
26. \u8d1d\u83b1\u5fb7\u3001\u6de1\u9a6c\u9521\u548c\u5efa\u8bbe\u94f6\u884c\u5c06\u5728\u4e2d\u56fd\u6210\u7acb\u8d44\u4ea7\u7ba1\u7406\u5408\u8d44\u4f01\u4e1a\u00a0<\/div>\n
\u5168\u7403\u6700\u5927\u8d44\u4ea7\u7ba1\u7406\u516c\u53f8\u8d1d\u83b1\u5fb7\u548c\u65b0\u52a0\u5761\u4e3b\u6743\u8d22\u5bcc\u57fa\u91d1\u6de1\u9a6c\u9521\uff0c\u5df2\u4e0e\u4e2d\u56fd\u5efa\u8bbe\u94f6\u884c\u7684\u8d22\u5bcc\u7ba1\u7406\u90e8\u95e8\u8fbe\u6210\u4e00\u9879\u975e\u7ea6\u675f\u534f\u8bae\uff0c\u5728\u4e2d\u56fd\u7ec4\u5efa\u4e00\u5bb6\u8d44\u4ea7\u7ba1\u7406\u5408\u8d44\u516c\u53f8\uff0c\u4e3a\u5f53\u5730\u7684\u4e2d\u56fd\u6295\u8d44\u8005\u5f00\u53d1\u548c\u5206\u9500\u4ea7\u54c1\u3002\uff08Wind\u8d44\u8baf\uff09<\/div>\n
\uff08\u5c01\u9762\u56fe\u6765\u6e90\/\u7f51\u7edc\uff09<\/div>\n
\u58f0\u660e\uff1a\u4ee5\u4e0a\u4fe1\u606f\u7f16\u8bd1\u6216\u6458\u5f55\u81ea\u516c\u5f00\u4fe1\u606f\uff0c\u4ec5\u4ee3\u8868\u4e2a\u4eba\u89c2\u70b9\uff0c\u4ec5\u4f9b\u7814\u7a76\u53c2\u8003\uff0c\u4e0d\u4f5c\u4e3a\u6295\u878d\u8d44\u53ca\u533b\u7597\u7b49\u51b3\u7b56\u4f9d\u636e\uff1b\u77e5\u8bc6\u7248\u6743\u5c5e\u4e8e\u57fa\u56e0\u6167\uff0c\u516c\u4f17\u53f7\u4ee5\u53ca\u673a\u6784\u8f6c\u8f7d\u8bf7\u5f81\u5f97\u57fa\u56e0\u6167\u4e66\u9762\u540c\u610f\u540e\uff0c\u5728\u6b63\u6587\u524d\u6ce8\u660e\u9996\u53d1\u51fa\u5904\u53ca\u4f5c\u8005\u59d3\u540d\u3002<\/div>\n
\u25bc \u300a2020\u57fa\u56e0\u884c\u4e1a\u62a5\u544a\u300b\u7eb8\u8d28\u7248\u5373\u5c06\u53d1\u552e<\/div>\n
\u57fa\u56e0\u6167\u7814\u7a76\u9662\u8bda\u610f\u51fa\u54c1<\/div>\n
\u8be6\u60c5\u8bf7\u5173\u6ce8\u201c\u57fa\u56e0\u6167\u201d\u5fae\u4fe1\u516c\u4f17\u53f7<\/div>\n\n
\n
\"RmFicvQBAkgDEHHXxdhicKbgtwQD8bKN90CgEwGrBLicPlP9VS3QxwjVOuAU8cdx7QGZw7fB3H8CgmnVtyibBVt5pQ\"\/<\/figure><\/div>\n\n<\/div>\n
<\/div>\n
\u25bc\u00a0\u5f80\u5e74\u57fa\u56e0\u6167\u5e74\u5ea6\u91cd\u78c5\u62a5\u544a\u4e00\u89c8<\/div>\n
<\/div>\n
\n\n
\n
\"?wx_fmt=jpeg\"\/<\/figure><\/div>\n\n
\u56fe\uff1a\u57fa\u56e0\u6167\u7814\u7a76\u9662\u51fa\u54c1\u7cfb\u5217\u884c\u4e1a\u62a5\u544a\uff0c\u4f9d\u6b21\u4e3a\uff1a\u300a2019\u5e74\u57fa\u56e0\u884c\u4e1a\u62a5\u544a\u300b<\/a>\u3001\u300a2018-2019\u5e74\u4e2d\u57fa\u56e0\u884c\u4e1a\u62a5\u544a\u300b<\/a>\u3001\u300a2018\u5e74\u57fa\u56e0\u884c\u4e1a\u521b\u6295\u62a5\u544a\u300b<\/a><\/div>\n
\u00a0<\/div>\n
\u00a0\u57fa\u56e0\u6167\u62db\u8058\u00a0<\/div>\n
\u57fa\u56e0\u6167\u884c\u4e1a\u5206\u6790\u5458<\/div>\n
\u65b0\u5a92\u4f53\u4e3b\u7f16<\/div>\n
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