{"id":9169,"date":"2020-01-04T22:38:22","date_gmt":"2020-01-04T14:38:22","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&mid=100012332&idx=1&sn=28248ea7bda6101290ef428f59691e9b&chksm=6b71439b5c06ca8d6103e9903ae8f9ccee5e2298622e537446f482fd971f64c875ac47ad793c#rd"},"modified":"2026-04-08T10:04:31","modified_gmt":"2026-04-08T02:04:31","slug":"544852","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2020\/01\/04\/544852\/","title":{"rendered":"\u57fa\u56e0\u9ed1\u79d1\u6280RNAi\u653b\u514b\u4e34\u5e8a\u96be\u9898\uff0c\u53d7\u836f\u5382\u6570\u5341\u4ebf\u7f8e\u5143\u6295\u5165"},"content":{"rendered":"

<\/p>\n

\u5317\u4eac\u65f6\u95f42019\u5e7411\u670819\u65e5\uff0cNovo Nordisk\uff08\u751f\u7269\u5236\u836f\u516c\u53f8\uff09\u4e0eDicerna Pharmaceuticals\u8fbe\u6210\u7814\u7a76\u534f\u8bae\uff0c\u5229\u7528Dicerna Pharmaceuticals\u7684GalXC\u2122\u5e73\u53f0\u5171\u540c\u6765\u53d1\u73b0\u548c\u7814\u53d1RNA\u5e72\u6270\uff08RNAi\uff09\u7597\u6cd5\uff0c\u7528\u4e8e\u6cbb\u7597\u6162\u6027\u809d\u75c5\uff0c\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff0c2\u578b\u7cd6\u5c3f\u75c5\uff0c\u80a5\u80d6\u75c7\u4ee5\u53ca\u7f55\u89c1\u75be\u75c5\u3002\u672c\u6587\u6839\u636e\u76f8\u5173\u516c\u5f00\u8d44\u6599\u8fdb\u884c\u521d\u6b65\u5206\u6790\uff0c\u6b22\u8fce\u7559\u8a00\u8ba8\u8bba\u3002<\/div>\n\n
\n
\"RmFicvQBAkgBh4E01IAELyNAH5VLnJb9z2ViaAfibzSGnbD1UFbBd3F7IQzGZDShKtsgDHkVALcElfeA70DkunJ2Q\"\/<\/figure><\/div>\n\n
\u56fe\uff1a\u201c\u57fa\u56e0+\u836f\u201d\uff08\u6765\u6e90\/\u7f51\u7edc\uff0c\u4e0b\u540c\uff09<\/div>\n
\u4e00\u3001\u836f\u538238\u4ebf\u7f8e\u5143\u5408\u4f5cRNAi<\/div>\n
\u968f\u7740RNAi\u6280\u672f\u7684\u53d1\u5c55\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u836f\u5382\u4e0d\u60dc\u82b1\u4e0b\u91cd\u91d1\uff0c\u901a\u8fc7RNAi\u6280\u672f\u6765\u7814\u7a76\u836f\u7269\u7684\u7814\u53d1\u548c\u5229\u7528\u3002<\/div>\n
\u5317\u4eac\u65f6\u95f42019\u5e7411\u670819\u65e5\uff0c Novo Nordisk\uff08\u751f\u7269\u5236\u836f\u516c\u53f8\uff09\u4e0eDicerna Pharmaceuticals\u8fbe\u6210\u7814\u7a76\u534f\u8bae\uff0c\u5229\u7528Dicerna Pharmaceuticals\u516c\u53f8\u7684GalXC\u2122\u5e73\u53f0\u5171\u540c\u6765\u53d1\u73b0\u548c\u7814\u53d1RNA\u5e72\u6270\uff08RNAi\uff09\u7597\u6cd5\uff0c\u7528\u4e8e\u6cbb\u7597\u6162\u6027\u809d\u75c5\uff0c\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff0c2\u578b\u7cd6\u5c3f\u75c5\uff0c\u80a5\u80d6\u75c7\u4ee5\u53ca\u7f55\u89c1\u75be\u75c5\u3002<\/div>\n
\u7531\u4e8eNovo Nordisk\u8ba1\u5212\u901a\u8fc7\u5408\u4f5c\u610f\u5728\u5f00\u53d110\u79cd\u6216\u66f4\u591a\u4ea7\u54c1\uff0c\u5176\u6295\u8d44\u6f5c\u5728\u7684\u603b\u4ef7\u503c\u5c06\u8fd1\u9ad8\u8fbe38\u4ebf\u7f8e\u91d1\u3002<\/div>\n
\u00a0<\/div>\n
\u5408\u4f5c\u4e2d\uff0cDicerna\u548cNovo Nordisk\u53cc\u65b9\u8868\u793a\uff0c\u4ed6\u4eec\u6253\u7b97\u4f7f\u7528Dicerna\u7684\u809d\u810f\u9776\u5411GalXC\u6280\u672f\uff0c\u7740\u773c\u4e8e\u63a2\u7d22\u548c\u8bc4\u4f3030\u591a\u4e2a\u809d\u810f\u9776\u6807\uff0c\u4f7f\u7528\u9488\u5bf9\u809d\u810f\u7684\u57fa\u4e8eGalXC\u7684\u5316\u5408\u7269\u6765\u5b9e\u73b0RNAi\u7597\u6cd5\u7684\u76ae\u4e0b\u9012\u9001\uff0c\u8fd9\u79cd\u7597\u6cd5\u65e8\u5728\u4e0e\u809d\u7ec6\u80de\u4e0a\u7684\u53d7\u4f53\u7279\u5f02\u6027\u7ed3\u5408\uff0c\u4ece\u800c\u5bfc\u81f4\u5185\u5316\u5e76\u8fdb\u5165\u7ec6\u80de\u5185\u53d1\u751fRNA\u5e72\u6270\u4f5c\u7528\u3002<\/div>\n
Fambrough\u8bf4\uff0c\u201cGalXC\u4f7f\u6211\u4eec\u6709\u53ef\u80fd\u521b\u9020\u51fa\u9ad8\u6548\u3001\u5b89\u5168\u3001\u9ad8\u9009\u62e9\u6027\u7684RNAi\u7597\u6cd5\uff0c\u8be5\u7597\u6cd5\u5bf9\u7279\u5b9a\u57fa\u56e0\u548c\u809d\u7ec6\u80de\u90fd\u6709\u9009\u62e9\u6027\u201d\u3002<\/div>\n
\u00a0<\/div>\n
\u4e8c\u3001\u76ee\u524d\u5df2\u83b7\u5f97\u6279\u51c6\u7684RNAi\u836f\u7269<\/div>\n
RNAi\u6280\u672f\u7684\u9010\u6e10\u6210\u719f\uff0c\u4f7f\u5f97\u5404\u5927\u836f\u5382\u90fd\u60f3\u5229\u7528\u8fd9\u4e2a\u65b0\u6280\u672f\u7814\u53d1\u65b0\u836f\u6765\u5b9e\u73b0\u5bf9\u7591\u96be\u6742\u75c7\u7684\u6cbb\u7597\uff0c\u76ee\u524d\u5728\u7814\u6216\u662f\u5df2\u7ecf\u7ecfFDA\u6279\u51c6\u4e0a\u5e02\u7684\u4e00\u4e9bRNAi\u4ee3\u8868\u6027\u836f\u7269\u3002<\/div>\n\n
\n
\"RmFicvQBAkgBh4E01IAELyNAH5VLnJb9zyiaKQnibeiamWpCjzdohoywHnfd2KepjDFPlWmtibzuiaIRpW6axwwbibZvg\"\/<\/figure><\/div>\n\n
\u8868\uff1a\u76ee\u524d\u5728\u7814\u6216\u662f\u7ecfFDA\u6279\u51c6\u4e0a\u5e02\u7684RNAi\u4ee3\u8868\u6027\u836f\u7269 (1)\u00a0<\/div>\n
\u25a0 \u5168\u7403\u7b2c\u4e00\u6b3eRNAi\u836f\u7269<\/div>\n
2018\u5e748\u670810\u65e5\uff0c\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u9996\u6b3eRNAi\u836f\u7269Onpattro\u7528\u4e8e\u6cbb\u7597\u9057\u4f20\u6027\u8f6c\u7532\u72b6\u817a\u7d20\u86cb\u767d\u6dc0\u7c89\u6837\u53d8\u6027\uff08hATTR\uff09\u5f15\u8d77\u7684\u591a\u53d1\u6027\u795e\u7ecf\u75c5\u53d8\u7684\u6210\u5e74\u60a3\u8005\uff0c\u8fd9\u662f\u7f8e\u56fd\u9996\u4e2a\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u8be5\u9002\u5e94\u75c7\u7684\u836f\u7269\u3002\u00a0<\/div>\n
\u25a0\u00a0\u5168\u7403\u7b2c\u4e8c\u6b3eRNAi\u836f\u7269<\/div>\n
2019\u5e7411\u670820\u65e5\uff0cFDA\u5df2\u7ecf\u6279\u51c6\u4e86RNA\u5e72\u6270\u836f\u7269Givosiran\uff08Alnylam Pharmaceuticals\u2019Givlaari\uff09\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u6025\u6027\u809d\u6027\u535f\u5549\u75c7\uff08AHP\uff09\u3002\u5176\u4f59\u4e00\u4e9b\u836f\u7269\u8fd8\u5728\u4e34\u5e8a\u5b9e\u9a8c\u9636\u6bb5\u3002<\/div>\n
\u00a0<\/div>\n
\u4e09\u3001RNAi\u662f\u4ec0\u4e48\u5462\uff1f<\/div>\n
RNAi\u7684\u7814\u7a76\u5386\u7a0b\u4e2d\uff0cRNAi\u57282002\u5e74\u88abScience\u00a0\u6742\u5fd7\u8bc4\u4e3a\u7684\u5341\u5927\u79d1\u5b66\u8fdb\u5c55\u4e4b\u4e00\u30022004\u5e749\u6708\uff0cScience\u00a0\u9996\u6b21\u520a\u767b\u4e86\u7f8e\u56fd\u79d1\u5b66\u5bb6Andrew Z. Fire\u4e0eCraig C. Mello\u7b49\u4eba\u64b0\u5199\u7684\u5173\u4e8eRNA\u5e72\u6270\u7684\u6210\u679c\u6587\u7ae0\u3002Andrew Fire\u548cCraig C. Mello\u56e0\u5728RNA\u5e72\u6270\u7ebf\u866b\u65b9\u9762\u7684\u7814\u7a76\u800c\u83b7\u5f972006\u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u3002<\/div>\n
\u00a0<\/div>\n
\u968f\u7740\u8bfa\u8d1d\u5c14\u5956\u7684\u8bde\u751f\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u8005\u7740\u773c\u4e8eRNAi\u7684\u6280\u672f\uff0c\u90a3\u4e48RNAi\u662f\u4ec0\u4e48\u5462\uff1f\u00a0<\/div>\n
RNAi\u662f\u4e00\u79cd\u57fa\u56e0\u8c03\u63a7\u673a\u5236\uff0c\u7531\u4e00\u7cfb\u5217\u6838\u7cd6\u6838\u9178\u8bf1\u5bfc\u6c89\u9ed8\u590d\u5408\u7269(RNA-induced silencing complex, RISC)\u4ecb\u5bfc\uff0c\u53ef\u4ee5\u9488\u5bf9\u4efb\u4f55\u7279\u5b9a\u7684\u57fa\u56e0\u3002<\/div>\n
\u5c0f\u7684\u8c03\u63a7RNA\u5206\u5b50\u7ec4\u88c5\u6210RISC\u5e76\u5f15\u5bfc\u590d\u5408\u7269\u4e0e\u9776mRNA\u8f6c\u5f55\u672c\u4e92\u8865\u7ed3\u5408\u3002\u4e00\u65e6RISC\u88c5\u8f7d\u4e86\u5c0f\u7684\u8c03\u63a7RNA\uff0c\u5b83\u53ef\u4ee5\u901a\u8fc7\u51e0\u79cd\u4e0d\u540c\u7684\u673a\u5236\u6765\u6c89\u9ed8\u76ee\u6807\u57fa\u56e0\uff0c\u5305\u62ec\u4e0d\u5b8c\u5168\u4e92\u8865\u7684mRNA\u7684\u7ffb\u8bd1\u6291\u5236\u548c\u964d\u89e3\uff0c\u4ee5\u53ca\u5b8c\u5168\u4e92\u8865\u7684mRNA\u7684\u5e8f\u5217\u7279\u5f02\u6027\u88c2\u89e3 (2, 3\u00a0)\u3002<\/div>\n\n
\n
\"RmFicvQBAkgBh4E01IAELyNAH5VLnJb9zibMDFS3UpuUwFnepPnbpkS6y3xNicAbcicxswV4QYlkyj8lr1tCn6ooFg\"\/<\/figure><\/div>\n\n<\/div>\n
\u56fe\uff1aRNAi\u5728\u57fa\u56e0\u8868\u8fbe\u7684\u8c03\u63a7\u4f5c\u7528<\/div>\n
<\/div>\n
<\/div>\n
\u901a\u4fd7\u6765\u8bb2\uff0cRNAi\u6307\u6211\u4eec\u901a\u8fc7\u5185\u6e90\u6027\u6216\u662f\u5916\u6e90\u6027\u7684\u53cc\u94feRNA\uff08dsRNA\uff09\u4ecb\u5bfc\uff0c\u7279\u5f02\u6027\u7ed3\u5408\u76f8\u5e94\u5e8f\u5217\u7684mRNA\u5e76\u5c06\u5176\u964d\u89e3\uff0c\u5bfc\u81f4\u9776\u57fa\u56e0\u7684\u8868\u8fbe\u6c89\u9ed8\uff0c\u662f\u5c5e\u4e8e\u8f6c\u5f55\u540e\u6c34\u5e73\u7684\u57fa\u56e0\u6c89\u9ed8\u3002<\/div>\n
<\/div>\n
\u76ee\u524d\uff0cRNA\u5e72\u6270\u673a\u5236\u7684\u53d1\u73b0\u5f7b\u5e95\u6539\u53d8\u4e86\u5b9e\u9a8c\u57fa\u56e0\u7684\u8c03\u63a7\u3002\u7814\u7a76\u8005\u53ef\u4ee5\u5f88\u5bb9\u6613\u8bbe\u8ba1\u5e76\u4e14\u5feb\u901f\u5408\u6210siRNA\u9776\u5411\u4e92\u8865mRNA\u5e8f\u5217\u3002\u4e0e\u4e34\u5e8a\u76f8\u5173\u7684\u662f\uff0c\u4e0e\u9776\u5206\u5b50\u7ed3\u5408\u7684\u836f\u7269\u76f8\u6bd4\uff0c\u540c\u4e00siRNA\u5206\u5b50\u5728\u8fde\u7eed\u51e0\u8f6e\u78b1\u57fa\u914d\u5bf9\u4e2d\u9776\u5411\u591a\u4e2amRNA\u5206\u5b50\u3002<\/div>\n
<\/div>\n
\u56e0\u6b64\uff0cRNAi\u673a\u5236\u7684\u53d1\u73b0\u4e3a\u5f00\u53d1\u57fa\u4e8eRNAi\u7684\u7597\u6cd5\u5960\u5b9a\u4e86\u57fa\u7840\u3002<\/div>\n
<\/div>\n
<\/div>\n
<\/div>\n
\u56db\u3001RNAi\u7684\u7814\u7a76\u5386\u7a0b<\/div>\n
\n\n
\n
\"RmFicvQBAkgCCz9bXVkgu2Qc8zPteW4X2gKQXK2S5LNuoR2Gric0t0UBTYBa5J74PkO6Jp5fDicgZiatLrounOZvOg\"\/<\/figure><\/div>\n\n
\u56fe\uff1aRNAi\u7684\u7814\u7a76\u5386\u7a0b<\/div>\n
\u4ece1972\u52301998\u5e74\uff0c\u4ece\u6b63\u4e49\u4e0e\u53cd\u4e49RNA\u7684\u7814\u7a76\u5230RNAi\u63d0\u51fa\uff0c\u7ecf\u5386\u4e8626\u5e74\u3002RNAi\u7684\u53d1\u73b0\u89e3\u91ca\u4e86\u690d\u7269\u548c\u771f\u83cc\u4e2d\u4e00\u76f4\u4ee4\u4eba\u7591\u60d1\u7684\u7684\u57fa\u56e0\u6c89\u9ed8\u73b0\u8c61\uff0c\u5e76\u5f00\u542f\u4e86\u4e00\u573a\u751f\u7269\u5b66\u9769\u547d\uff0c\u6700\u7ec8\u8bc1\u660enon-coding RNA\u662f\u591a\u7ec6\u80de\u751f\u7269\u4e2d\u57fa\u56e0\u8868\u8fbe\u7684\u4e2d\u5fc3\u8c03\u63a7\u56e0\u5b50 (4)\u3002<\/div>\n
\u00a0<\/div>\n
2001\u5e74\uff0cElbashir\u548cCaplen\u62a5\u9053\u4e8621-22\u4e2a\u6838\u82f7\u9178(nt)\u7684 dsRNAs\u53ef\u4ee5\u5728\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u4e2d\u8bf1\u5bfcRNAi\u6c89\u9ed8\u4e14\u4e0d\u4f1a\u5f15\u8d77\u975e\u7279\u5f02\u6027\u7684\u5e72\u6270\u7d20\u53cd\u5e94\u3002\u8fd9\u4e9bsiRNA\u5f88\u5feb\u6210\u4e3a\u751f\u7269\u7814\u7a76\u4e2d\u666e\u904d\u5b58\u5728\u7684\u5de5\u5177\u3002\u00a0<\/div>\n
\u5bf9\u836f\u7269\u5f00\u53d1\u4eba\u5458\u6765\u8bf4\uff0csiRNAs\u7684\u6548\u529b\u548c\u5e94\u7528\u5e7f\u6cdb\u6027\u3001\u6291\u5236\u7f16\u7801\u86cb\u767d\u8d28\u7684\u57fa\u56e0\u7684\u524d\u666f\u90fd\u88ab\u8bc1\u660e\u662f\u975e\u5e38\u8bf1\u4eba\u7684\uff0c\u4e0d\u5bb9\u5ffd\u89c6\u3002\u52302003\u5e74\uff0c\u5df2\u7ecf\u6709\u591a\u5bb6\u836f\u7269\u516c\u53f8\u6210\u7acb\uff0c\u6765\u7814\u7a76RNAi\u7684\u6cbb\u7597\u6f5c\u529b\u3002\u00a0<\/div>\n
\u00a0<\/div>\n
\u4e0d\u5e78\u7684\u662f\uff0c\u9996\u6b21\u4f7f\u7528\u672a\u7ecf\u4fee\u9970\u7684siRNAs\u836f\u7269\u8fdb\u884c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4ea7\u751f\u4e86\u4e0e\u514d\u75ab\u76f8\u5173\u7684\u6bd2\u6027\u548c\u53ef\u7591\u7684RNAi\u6548\u5e94 (5, 6)\u3002\u7b2c\u4e8c\u6ce2\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4f8b\u5982\u9996\u6b21\u8bc1\u5b9e\u7cfb\u7edf\u7ed9\u836f\u7684\u7eb3\u7c73\u9897\u7c92\u5bf9\u4eba\u4f53\u5177\u6709RNAi\u4f5c\u7528\uff0c\u4f46\u4e5f\u663e\u793a\u51fa\u663e\u8457\u7684\u5242\u91cf\u9650\u5236\u7684\u6bd2\u6027\u548c\u6cbb\u7597\u6548\u679c\u4e0d\u8db3\u3002\u7ed3\u679c\uff0c2010\u5e74\u65e9\u671f\u4e00\u4e9b\u77e5\u540d\u5236\u836f\u516c\u53f8\u9000\u51fa\u4e86RNAi\u9886\u57df\uff0c\u9020\u6210\u4e86\u8be5\u884c\u4e1a\u7684\u91d1\u878d\u5371\u673a (7)\u3002\u00a0<\/div>\n
\u540e\u7eed\u7684\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u8005\u4ece\u4ee5\u524d\u7684\u4e34\u5e8a\u5931\u8d25\u4e2d\u5438\u53d6\u6559\u8bad\uff0c\u7740\u529b\u5728\u5e8f\u5217\u7684\u9009\u62e9\uff0c\u5316\u5b66\u914d\u65b9\u4ee5\u53ca\u4f20\u9012\u673a\u5236\u65b9\u9762\u8fdb\u884c\u7814\u7a76\uff0c\u5e76\u53d6\u5f97\u5f88\u5927\u8fdb\u6b65\u3002<\/div>\n
\u00a0<\/div>\n
2018\u5e748\u670810\u65e5\uff0c\u9996\u6b3eRNAi\u836f\u7269Onpattro\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u9057\u4f20\u6027\u8f6c\u7532\u72b6\u817a\u7d20\u86cb\u767d\u6dc0\u7c89\u6837\u53d8\u6027\uff08hATTR\uff09\u5f15\u8d77\u7684\u591a\u53d1\u6027\u795e\u7ecf\u75c5\u53d8\u7684\u6210\u5e74\u60a3\u8005\u30022019\u5e7411\u670820\u65e5\uff0c\u7b2c\u4e8c\u6b3eRNA\u5e72\u6270\u836f\u7269Givosiran\uff08Alnylam Pharmaceuticals\u2019Givlaari\uff09\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u6025\u6027\u809d\u6027\u535f\u5549\u75c7\uff08AHP\uff09\u3002<\/div>\n
\u76ee\u524dRNAi\u7597\u6cd5\uff0c\u6b63\u662f\u836f\u754c\u7814\u7a76\u7684\u9999\u997d\u997d\u3002<\/div>\n
\u00a0<\/div>\n
\u3010\u7ed3\u8bed\u3011<\/div>\n
\u7531\u4e8eRNAi\u4f5c\u7528\u7684\u9ad8\u5ea6\u7279\u5f02\u6027\uff0c\u6709\u53ef\u80fd\u7279\u5f02\u5730\u6291\u5236\u81f4\u75c5\u7684\u7a81\u53d8\u7b49\u4f4d\u57fa\u56e0\uff0c\u6240\u4ee5RNAi\u5728\u75be\u75c5\u7684\u57fa\u56e0\u6cbb\u7597\u4e0a\u6709\u5e7f\u9614\u7684\u5e94\u7528\u524d\u666f\u3002<\/div>\n
RNAi\u6280\u672f\u7684\u5e94\u7528\uff0c\u4e0d\u4ec5\u80fd\u63a8\u8fdb\u4eba\u7c7b\u65b0\u836f\u5f00\u53d1\u3001\u533b\u5b66\u7814\u7a76\uff08\u4f8b\u5982\u5668\u5b98\u79fb\u690d\uff09\u3001\u795e\u7ecf\u7cfb\u7edf\u7814\u7a76\u7b49\u9886\u57df\uff0c\u540c\u65f6\u8fd8\u80fd\u5229\u7528RNAi\u6280\u672f\u6765\u6291\u5236\u57fa\u56e0\u7684\u5f02\u5e38\u8868\u8fbe\uff0c\u4e3a\u6cbb\u7597\u764c\u75c7\u3001\u7cbe\u795e\u75c5\u7b49\u75be\u75c5\u63d0\u4f9b\u4e86\u65b0\u601d\u8def\u3002\u00a0<\/div>\n
\u00a0<\/div>\n
\u5c3d\u7ba1\u5728RNAi\u7684\u7814\u7a76\u4e2d\uff0c\u53d6\u5f97\u4e86\u5f53\u524d\u7684\u6210\u529f\u3002\u540c\u65f6\u5927\u5bb6\u90fd\u5f88\u6e05\u695a\uff0c\u5728\u4e34\u5e8a\u73af\u5883\u4e2d\uff0c\u5982\u679c\u4f7f\u5f97RNAi\u6cbb\u7597\u836f\u7269\u80fd\u591f\u88ab\u5168\u8eab\u6027\u8f93\u9001\uff08\u4f8b\u5982\u4f20\u9012\u5230\u975e\u809d\u810f\u3001\u975e\u80be\u810f\u7ec4\u7ec7\u7b49\uff09\u53d8\u5f97\u53ef\u884c\uff0c\u90a3\u4e48RNAi\u7597\u6cd5\u53ef\u80fd\u4f1a\u4ea7\u751f\u66f4\u5927\u7684\u5f71\u54cd\u3002<\/div>\n
\u8fd9\u5c31\u8981\u6c42\u5316\u5b66\u5bb6\u548c\u751f\u7269\u5b66\u5bb6\u4e4b\u95f4\u8fdb\u884c\u66f4\u7d27\u5bc6\u7684\u5408\u4f5c\uff0c\u4ee5\u5f00\u53d1\u5229\u7528\u5fae\u5999\u7684\u751f\u7269\u9014\u5f84\u65b9\u9762\u7684\u89e3\u51b3\u65b9\u6848\u3002<\/div>\n
\u00a0<\/div>\n
\u53c2\u8003\u8d44\u6599\uff1a<\/div>\n
1\uff09C. Morrison, Alnylam prepares to land first RNAi drug approval. Nat Rev Drug Discov 17, 156-157 (2018).<\/div>\n
2\uff09A. J. Pratt, I. J. MacRae, The RNA-induced silencing complex: a versatile gene-silencing machine. J Biol Chem 284, 17897-17901 (2009).<\/div>\n
3\uff09J. C. Burnett, J. J. Rossi, RNA-based therapeutics: current progress and future prospects. Chem Biol 19, 60-71 (2012).<\/div>\n
4\uff09R. L. Setten, J. J. Rossi, S. P. Han, Author Correction: The current state and future directions of RNAi-based therapeutics. Nat Rev Drug Discov, (2019).<\/div>\n
5\uff09M. E. Kleinman et al., Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature 452, 591-597 (2008).<\/div>\n
6\uff09J. DeVincenzo et al., A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus. Proc Natl Acad Sci U S A 107, 8800-8805 (2010).<\/div>\n
7\uff09D. Haussecker, The Business of RNAi Therapeutics in 2012. Mol Ther Nucleic Acids 1, e8 (2012).<\/div>\n
\uff08\u5c01\u9762\u56fe\u6765\u6e90\/\u6444\u56fe\u7f51\u6388\u6743\u8d2d\u4e70\uff09<\/div>\n
\u58f0\u660e\uff1a\u4ee5\u4e0a\u89c2\u70b9\u4ec5\u4ee3\u8868\u4f5c\u8005\u4e2a\u4eba\uff0c\u4e0d\u4f5c\u4e3a\u6295\u8d44\u7b49\u51b3\u7b56\u4f9d\u636e\uff0c\u96be\u514d\u6709\u9519\u6f0f\uff0c\u6b22\u8fce\u7559\u8a00\u6307\u6b63\u8ba8\u8bba\u3002<\/div>\n
\u00a0<\/div>\n
\u25bc\u00a0\u300a2020\u57fa\u56e0\u884c\u4e1a\u62a5\u544a\u300b<\/div>\n
\u7eb8\u8d28\u7248\u65e9\u9e1f\u4f18\u60e0\u9884\u552e\u4e2d\uff08\u63d0\u7eb2\u9884\u89c8\uff09<\/a><\/div>\n
\u626b\u63cf\u6d77\u62a5\u4e2d\u4e8c\u7ef4\u7801\u62a2\u8d2d\u2193<\/div>\n\n
\n
\"RmFicvQBAkgCCz9bXVkgu2Qc8zPteW4X2FrKu4G3WKXGHLZTvfCrQ88KsZ75y70Xpes0y6Pl5VAOHOMXH263Zvw\"\/<\/figure><\/div>\n\n<\/div>\n
<\/div>\n\n
\u611f\u8c22\u4ee5\u4e0b\u652f\u6301\u5355\u4f4d\uff0c\u4f7f\u5f97\u62a5\u544a\u5e73\u4ef7\u53d1\u5e03<\/div>\n\n
\u00a0 \u8054\u5408\u63a8\u51fa\u00a0\u00a0 \u00a0\u00a0<\/div>\n
\u8bfa\u552f\u8d5e\u00a0\u00a0\u6850\u6811\u57fa\u56e0 \u00a0<\/div>\n
\u00a0\u6218\u7565\u5408\u4f5c\u00a0\u00a0 \u00a0\u00a0<\/div>\n
\u7eb3\u6602\u8fbe\u00a0 \u534e\u5927\u667a\u9020\u00a0 \u7fca\u5723\u751f\u7269\u00a0\u00a0<\/div>\n
\u5409\u56e0\u52a0\u00a0 \u81fb\u548c\u79d1\u6280\u00a0 \u5965\u7f8e\u6cf0\u514b\u00a0 \u767e\u4e16\u8bfa<\/div>\n
\u00a0\u9e23\u8c22\u5355\u4f4d\u00a0\u00a0 \u00a0\u00a0<\/div>\n
\u4f18\u8fc5\u533b\u5b66\u00a0 \u771f\u56fa\u751f\u7269\u00a0 \u679c\u58f3\u751f\u7269<\/div>\n\n
\u57fa\u56e0\u6167\u62db\u8058\u00a0<\/div>\n
\u5982\u679c\u60a8\u4e13\u6ce8\u57fa\u56e0\u884c\u4e1a\u5e02\u573a\u7814\u7a763\u5e74\u53ca\u4ee5\u4e0a<\/div>\n
\u70ed\u7231\u884c\u4e1a\u3001\u903b\u8f91\u5206\u6790\u3001\u6587\u7b14\u80fd\u529b\u5f3a<\/div>\n
\u6b22\u8fce\u6210\u4e3a\u57fa\u56e0\u6167\u884c\u4e1a\u5206\u6790\u5458\/\u65b0\u5a92\u4f53\u7f16\u8f91<\/div>\n
\u548c\u57fa\u56e0\u6167\u4e00\u8d77\u6df1\u5ea6\u7814\u7a76\u57fa\u56e0\u884c\u4e1a<\/div>\n
\u670d\u52a1\u751f\u547d\u7ecf\u6d4e\u521b\u65b0\u521b\u4e1a<\/div>\n
\uff08\u7b80\u5386\u6295\u9012\uff1ainfo@genonet.cn\uff09<\/div>\n
\u00a0<\/div>\n
\u00a0\u62d3\u5c55\u9605\u8bfb\u00a0<\/div>\n
18\u4f4d\u4e13\u5bb6\u5e74\u5ea6\u76d8\u70b9\u57fa\u56e0\u884c\u4e1a<\/a>\u00a0<\/div>\n
\u57fa\u56e0\u4ea7\u4e1a\u9ec4\u91d1\u5341\u5e74\u7684\u7b2c\u4e8c\u66f2\u7ebf<\/a>\u00a0\u00a0<\/div>\n
\u521b\u65b0\u836f\u7684\u7a81\u56f4\u642d\u6863\u662f\u57fa\u56e0\u6355\u624b<\/a><\/div>\n
\u00a0<\/div>\n
\u00a0\u5173\u4e8e\u57fa\u56e0\u6167\u00a0<\/div>\n
\u57fa\u56e0\u6167\u662f\u4e00\u5bb6\u72ec\u7acb\u7684\u57fa\u56e0\u548c\u6570\u5b57\u751f\u547d\u5065\u5eb7\u4ea7\u4e1a\u54a8\u8be2\u673a\u6784\uff0c\u57fa\u4e8e\u5341\u5e74\u4ea7\u4e1a\u5b9e\u8df5\uff0c\u5efa\u7acb\u4e86\u884c\u4e1a\u667a\u5e93\u3001\u4f01\u4e1a\u5e93YourMap\u00ae\u4ee5\u53ca\u4f20\u5a92\u5e73\u53f0\uff0c\u63d0\u4f9b\u4e13\u4e1a\u7684\u54a8\u8be2\u3001\u54c1\u724c\u53ca\u4fe1\u606f\u670d\u52a1\uff0c\u5e2e\u52a9\u5408\u4f5c\u4f19\u4f34\u6d1e\u5bdf\u5e02\u573a\uff0c\u5148\u4e00\u6b65\u770b\u89c1\u672a\u6765\uff0c\u670d\u52a1\u751f\u547d\u7ecf\u6d4e\u521b\u65b0\u4ea7\u4e1a\u3002<\/div>\n
\u2606\u00a0\u300a2019\u5e74\u6218\u7565\u6027\u65b0\u5174\u4ea7\u4e1a\u53d1\u5c55\u5c55\u671b\u300b\u7f16\u59d4<\/div>\n
\u2606\u00a0\u4e2d\u56fd\u9057\u4f20\u5b66\u4f1a\u751f\u7269\u4ea7\u4e1a\u4fc3\u8fdb\u59d4\u5458\u4f1a\u59d4\u5458<\/div>\n
\u2606\u00a0\u5168\u56fd\u536b\u751f\u4ea7\u4e1a\u4f01\u4e1a\u7ba1\u7406\u534f\u4f1a\u7cbe\u51c6\u533b\u7597\u5206\u4f1a\u7406\u4e8b<\/div>\n
\u2606\u00a0\u53c2\u4e0e\u7ec4\u7ec7\u300a\u57fa\u56e0\u68c0\u6d4b\u62a5\u544a\u6807\u51c6\u548c\u89c4\u8303\u5171\u8bc6\u300b<\/a><\/div>\n
\u2606\u00a0\u53d1\u5e03\u9996\u4e2a\u57fa\u56e0\u884c\u4e1a\u6570\u636e\u5e93<\/a>YourMap\u548c\u884c\u4e1a\u62a5\u544a<\/a><\/div>\n
\u2606\u00a0\u300a\u4e34\u5e8a\u751f\u7269\u6837\u672c\u5e93\u7684\u63a2\u7d22\u4e0e\u5b9e\u8df5\u300b<\/a>\u7f16\u59d4<\/div>\n
\u2606\u00a0\u5e7f\u4e1c\u7701\u7cbe\u51c6\u533b\u7597\u5e94\u7528\u5b66\u4f1a\u653f\u7b56\u7814\u7a76\u5e94\u7528\u5206\u4f1a\u5e38\u59d4<\/div>\n
\u2606\u00a0\u5e7f\u4e1c\u7701\u7cbe\u51c6\u533b\u7597\u5e94\u7528\u5b66\u4f1a\u9057\u4f20\u75c5\u5206\u4f1a\u5e38\u59d4\u00a0<\/div>\n
\u2606\u00a0\u7ec4\u7ec7\u57fa\u56e0\u68c0\u6d4b\u8054\u76df\uff08\u7b79\uff09\u53ca\u9996\u5c4a<\/a>\u3001\u7b2c\u4e8c\u5c4a\u4f1a\u8bae<\/a><\/div>\n
\u2606\u00a0\u4e3b\u529e\u9996\u5c4a\u6570\u5b57\u5065\u5eb7\u79c1\u8463\u4f1a<\/a><\/div>\n
\u2606\u00a0\u4e3b\u529e\u9996\u5c4a\u7ca4\u6e2f\u6fb3\u5927\u6e7e\u533a\u751f\u547d\u5065\u5eb7\u521b\u65b0\u8bba\u575b<\/a><\/div>\n
\u2606\u00a0\u7b2c\u4e5d\u5c4a\u4e2d\u56fd\u6df1\u5733\u521b\u65b0\u521b\u4e1a\u5927\u8d5b\u76d0\u7530\u533a\u51b3\u8d5b\u8bc4\u59d4<\/div>\n
\u2606\u00a0\u53d7\u9080\u51fa\u5e2d\u6210\u90fd\u7cbe\u51c6\u533b\u5b66\u56fd\u9645\u8bba\u575b<\/a>\u7b49\u5927\u4f1a\u4f5c\u62a5\u544a<\/div>\n
\u2606\u00a0\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u7cbe\u51c6\u533b\u7597EMBA\u534f\u4f5c\u5355\u4f4d<\/div>\n\n
\n
\"RmFicvQBAkgDwDDlibn6LGMERd60A1XgibkVTEVrPEb1EoTK1HnjticKMtrzWS4eyuZgibs4H2ErBL6cp0GRTKvEAkg\"\/<\/figure><\/div>","protected":false},"excerpt":{"rendered":"

RNAi\u4e0e\u836f\u7269\u7684\u78b0\u649e<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[1780,1781],"class_list":["post-9169","post","type-post","status-publish","format-standard","hentry","category-industryresearch","tag-rna","tag-1781"],"_links":{"self":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/9169","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/comments?post=9169"}],"version-history":[{"count":4,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/9169\/revisions"}],"predecessor-version":[{"id":13872,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/9169\/revisions\/13872"}],"wp:attachment":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/media?parent=9169"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/categories?post=9169"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/tags?post=9169"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}