{"id":9167,"date":"2020-01-20T04:57:13","date_gmt":"2020-01-19T20:57:13","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&#038;mid=100012378&#038;idx=1&#038;sn=c0dbdbce3e4c0bc3d91cff486a8e54fc&#038;chksm=6b7143ed5c06cafb5ac2896ad23c85dcd46d6576e4310f432ca327e4cab74fc38850d831f56e#rd"},"modified":"2026-04-08T10:04:11","modified_gmt":"2026-04-08T02:04:11","slug":"5098102","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2020\/01\/20\/5098102\/","title":{"rendered":"\u672a\u6765\u5341\u5e74\uff0c\u764c\u75c7\u7814\u7a76\u65b9\u5411"},"content":{"rendered":"<p><!-- wechat_content_hash: 2bfa317c0102e51c --><\/p>\n<div>\u5173\u952e\u8bcd\/\u884c\u4e1a\u76d8\u70b9 \u764c\u75c7<\/div>\n<div>\u539f\u6587\/Nature Cancer<\/div>\n<div>\u7f16\u8bd1\/\u738b\u6167\u71d5\u3001\u6c6a\u4eae\uff08\u57fa\u56e0\u6167\uff09<\/div>\n<div>\u00a0<\/div>\n<div>2020\u5e741\u670814\u65e5\uff0cNature Cancer\u671f\u520a\u53d1\u8868\u5168\u7403\u5341\u4f4d\u764c\u75c7\u7814\u7a76\u77e5\u540d\u4e13\u5bb6\u5173\u4e8e\u672a\u6765\u5341\u5e74\u764c\u75c7\u7814\u7a76\u548c\u4e0b\u4e00\u4e2a\u7a81\u7834\u7684\u89c1\u89e3\uff0c\u5305\u62ec\u6211\u56fd\u5317\u4eac\u5927\u5b66\u5f20\u6cfd\u6c11\u6559\u6388\u3002\u6587\u7ae0\u5f00\u7bc7\u63d0\u5230\u6d4b\u5e8f\u6280\u672f\u5e73\u53f0\u548c\u5927\u6570\u636e\u63a8\u52a8\u764c\u75c7\u57fa\u7840\u7814\u7a76\u548c\u5e94\u7528\u8f6c\u5316\u3002\u57fa\u56e0\u6167\u7f16\u8bd1\u5168\u658710000\u4f59\u5b57\uff0c\u4ec5\u4f9b\u5b66\u672f\u53c2\u8003\uff0c\u96be\u514d\u6709\u9519\u6f0f\uff0c\u6b22\u8fce\u6307\u6b63\u3002\u66f4\u591a\u80bf\u7624\u7cbe\u51c6\u533b\u7597\u4ea7\u4e1a\u5206\u6790\u8bf7\u53c2\u9605\u300a2020\u57fa\u56e0\u884c\u4e1a\u62a5\u544a\u300b\uff0c\u7eb8\u8d28\u7248\u62a2\u8d2d\u89c1\u201c\u57fa\u56e0\u6167\u201d\u516c\u4f17\u53f7\u4e3b\u9875\u83dc\u5355\u3002<\/div>\n<div>* \u3010\u9080\u60a8\u5411\u57fa\u56e0\u6167\u6295\u7a3f\u3011\u5185\u5bb9\u6db5\u76d6\u79d1\u7814\u8fdb\u5c55\/\u4e34\u5e8a\u5e94\u7528\/\u4ea7\u4e1a\u5206\u6790\u7b49\uff1b\u5f55\u7528\u9664\u83b7\u5f97\u7a3f\u8d39\u5916\uff0c\u5c06\u83b7\u8d60\u4f5c\u8005\u53ca\u6240\u5728\u673a\u6784\u5ba3\u4f20\uff0c\u4f18\u5f02\u8005\u5f00\u8bbe\u4e13\u680f\uff08\u8054\u7cfb info@genonet.cn\uff09<\/div>\n<div>\u00a0<\/div>\n<div>\u5212\u91cd\u70b9<\/div>\n<div>1. \u8377\u5170\u764c\u75c7\u7814\u7a76\u6240 Ren\u00e9 Bernards\uff1a\u5f53\u764c\u7ec6\u80de\u5bf9\u6cbb\u7597\u4ea7\u751f\u8010\u53d7\u6027\u65f6\uff0c\u5e26\u6765\u989d\u5916\u7684\u533b\u7597\u6210\u672c\u540c\u65f6\u4e5f\u5e26\u6765\u201c\u83b7\u5f97\u6027\u8106\u5f31\u201d\uff0c\u53ef\u4ee5\u4f5c\u4e3a\u65b0\u7684\u9776\u6807\u3002\u5145\u5206\u5229\u7528\u8fd9\u70b9\uff0c\u65b0\u836f\u7814\u53d1\u5c06\u8fdb\u5165\u4e00\u4e2a\u65b0\u7684\u7eaa\u5143\u3002<\/div>\n<div>2. \u7ea6\u7ff0\u970d\u666e\u91d1\u65af\u5927\u5b66 Elizabeth Jaffee\uff1a\u514d\u75ab\u6cbb\u7597\u53d6\u5f97\u4e86\u91cd\u5927\u7a81\u7834\u5f97\u76ca\u4e8e\u57fa\u56e0\u7ec4\u5b66\u548c\u86cb\u767d\u8d28\u7ec4\u5b66\u6280\u672f\u52a0\u5feb\u9610\u660e\u514d\u75ab\u4fe1\u53f7\u901a\u8def\uff0c\u4ee5\u53ca\u5de5\u7a0b\u4eba\u6e90\u5316\u6297\u4f53\u548c\u5929\u7136\u4eba\u6e90\u6297\u4f53\u7684\u52a0\u901fT\u7ec6\u80de\u7597\u6cd5\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002NGS\u63a8\u52a8\u5f00\u53d1\u75ab\u82d7\u548c\u57fa\u56e0\u5de5\u7a0b\u5316T\u7ec6\u80de\u3002<\/div>\n<div>3. \u745e\u58eb\u8def\u5fb7\u7ef4\u5e0c\u764c\u75c7\u7814\u7a76\u6240 Johanna A.Joyce\uff1a\u9664\u4e86\u4e0d\u540c\u7684\u5668\u5b98\u5dee\u522b\u5916\uff0c\u5373\u4f7f\u5728\u76f8\u540c\u7684\u7ec4\u7ec7\u7c7b\u578b\u5185\uff0c\u4e0d\u540c\u7684\u9057\u4f20\u9a71\u52a8\u56e0\u5b50\u5728\u8c03\u63a7\u80bf\u7624\u5fae\u73af\u5883\u65b9\u9762\u4e5f\u53d1\u6325\u4e0d\u540c\u7684\u4f5c\u7528\u3002\u6211\u4eec\u9700\u8981\u96c6\u5408\u6240\u6709\u80bf\u7624\u5fae\u73af\u5883\u6210\u5206\uff0c\u4f5c\u4e3a\u8bc6\u522b\u548c\u9776\u5411\u764c\u75c7\u7684\u91cd\u8981\u624b\u6bb5\u3002<\/div>\n<div>4. \u7f8e\u56fd\u7ebd\u7ea6\u65af\u9686\u00b7\u51ef\u7279\u7433\u7eaa\u5ff5\u764c\u75c7\u4e2d\u5fc3 Scott W. Lowe\uff1a\u4f20\u7edf\u7684\u57fa\u56e0\u5de5\u7a0b\u5c0f\u9f20\u6a21\u578b\u7f13\u6162\u3001\u7e41\u7410\u4e14\u6602\u8d35\u3002\u4f53\u7ec6\u80de\u7ec4\u7ec7\u5de5\u7a0b\u53ef\u4ee5\u5c06\u764c\u75c7\u5efa\u6a21\u901f\u5ea6\u63d0\u9ad8\u4e00\u4e2a\u6570\u91cf\u7ea7\uff0c\u5e76\u4e14\u53ef\u4ee5\u51cf\u5c11\u52a8\u7269\u6570\u91cf\u548c\u6210\u672c\u3002<\/div>\n<div>\u00a0<\/div>\n<div>5. \u7f8e\u56fd\u513f\u7ae5\u533b\u9662\u57fa\u56e0\u7ec4\u533b\u5b66\u7814\u7a76\u6240 Elaine R.Mardis\uff1a\u201c\u57fa\u56e0-\u7a81\u53d8-\u6cbb\u7597\u201d\u65b9\u7a0b\u5f0f\u8fc7\u4e8e\u7b80\u5355\uff0c\u9700\u8003\u8651\u591a\u79cd\u57fa\u56e0\u7a81\u53d8\u3001DNA\u6d4b\u5e8f\u4e4b\u5916\u7684RNA\u6d4b\u5e8f\u3001\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7eb3\u5165\u771f\u5b9e\u4e16\u754c\u6570\u636e\u4ee5\u53ca\u63a8\u52a8\u60a3\u8005\u57fa\u56e0\u6570\u636e\u5171\u4eab\u7b49\u3002<\/div>\n<div>\u00a0<\/div>\n<div>6. \u7f8e\u56fd\u970d\u534e\u5fb7\u00b7\u4f11\u65af\u533b\u5b66\u9662 Sean J. Morrison\uff1a\u7ec6\u80de\u547d\u8fd0\u4e5f\u53d7\u8868\u89c2\u9057\u4f20\u548c\u4ee3\u8c22\u72b6\u6001\u4ee5\u53ca\u7ec4\u7ec7\u73af\u5883\u7684\u5f71\u54cd\u3002\u7a81\u53d8\u4f53\u514b\u9686\u4e0d\u662f\u764c\u7ec6\u80de\u3002\u672a\u6765\u5341\u5e74\u4e2d\u673a\u4f1a\u4e4b\u4e00\u5c06\u662f\u4e86\u89e3\u8bf1\u53d8\u5bf9\u7ec4\u7ec7\u4f53\u5185\u7a33\u6001\u548c\u764c\u75c7\u53d1\u751f\u7684\u5f71\u54cd\u3002<\/div>\n<div>7. \u7f8e\u56fd\u8fbe\u7eb3-\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u6240 Kornelia Polyak\uff1a\u5206\u6790\u80bf\u7624\u8f6c\u79fb\u9700\u8981\u7cfb\u7edf\u6027\u89d2\u5ea6\uff0c\u7efc\u5408\u8003\u8651\u5bbf\u4e3b\u7684\u7279\u6027\u548c\u80bf\u7624\u7684\u7279\u6027\uff0c\u4f8b\u5982\u53c2\u4e0e\u4e0a\u76ae\u5411\u95f4\u5145\u8d28\u8f6c\u5316\u7684\u57fa\u56e0\u548c\u7ec6\u80de\u3001\u80bf\u7624\u5fae\u73af\u5883\u3001\u5916\u6ccc\u4f53\u7b49\u975e\u7ec6\u80de\u81ea\u4e3b\u56e0\u5b50\u4ee5\u53ca\u9057\u4f20\u53d8\u5f02\u7b49\u3002<\/div>\n<div>8. \u7f8e\u56fd\u7ea6\u7ff0\u970d\u666e\u91d1\u65af\u5927\u5b66\u533b\u5b66\u9662 Cynthia L. Sears\uff1a\u6211\u4eec\u5bf9\u81f4\u764c\u6027\u5fae\u751f\u7269\u548c\u7fa4\u843d\u672c\u8eab\u4ee5\u53ca\u5bf9\u80bf\u7624\u5fae\u73af\u5883\u5f71\u54cd\u7684\u673a\u5236\u4ecd\u7f3a\u4e4f\u4e86\u89e3\uff0c\u4f46\u8fd9\u662f\u4e00\u4e2a\u5145\u6ee1\u673a\u4f1a\u7684\u9886\u57df\uff0c\u9700\u8981\u7ed3\u5408\u57fa\u56e0\u7ec4\u5b66\u3001\u4ee3\u8c22\u7ec4\u5b66\u548c\u5176\u4ed6\u9886\u57df\u8054\u5408\u7814\u7a76\u3002<\/div>\n<div>\u00a0<\/div>\n<div>9. \u82f1\u56fd\u5f17\u6717\u897f\u65af\u00b7\u514b\u91cc\u514b\u7814\u7a76\u6240 Karen H.Vousden\uff1a\u6700\u4ee4\u4eba\u5174\u594b\u7684\u524d\u666f\u4e4b\u4e00\uff0c\u662f\u6539\u53d8\u5168\u8eab\u65b0\u9648\u4ee3\u8c22\u6216\u5168\u8eab\u8425\u517b\u6c34\u5e73\uff08\u5b9a\u5236\u996e\u98df\uff09\uff0c\u5c06\u901a\u8fc7\u9776\u5411\u80bf\u7624\u672c\u8eab\u6216\u5f15\u53d1\u5bbf\u4e3b\u53cd\u5e94\uff08\u4f8b\u5982\u514d\u75ab\u9632\u5fa1\uff09\u6765\u9a71\u52a8\u6216\u589e\u5f3a\u6cbb\u7597\u53cd\u5e94\u3002<\/div>\n<div>10. \u5317\u4eac\u5927\u5b66\u751f\u547d\u79d1\u5b66\u5b66\u9662\u5f20\u6cfd\u6c11\uff1a\u6211\u4eec\u6bd4\u4ee5\u5f80\u4efb\u4f55\u65f6\u5019\u90fd\u66f4\u9700\u8981\u5173\u6ce8\u5355\u4e2a\u7ec6\u80de\u7684\u89c6\u89d2\uff1b\u4e13\u6ce8\u7814\u7a76\u548c\u9776\u5411TME\u4efb\u4f55\u4e00\u4e2a\u7ec4\u6210\u90e8\u5206\uff0c\u5c06\u4f7f\u6211\u4eec\u80fd\u591f\u4ece\u6839\u672c\u4e0a\u6539\u53d8\u6e38\u620f\u89c4\u5219\uff0c\u65e0\u8bba\u662f\u764c\u75c7\u8fd8\u662f\u5176\u4ed6\u75be\u75c5\u7814\u7a76\u3002<\/div>\n<div>\u00a0<\/div>\n<div>Nature Cancer\u6307\u51fa\uff0c\u4e8c\u5341\u4e00\u4e16\u7eaa\u7684\u7b2c\u4e09\u4e2a\u5341\u5e74\u4e4b\u4ea4\uff0c\u764c\u75c7\u7814\u7a76\u53d6\u5f97\u663e\u8457\u8fdb\u5c55\uff0c\u5c24\u5176\u662f\u4f34\u968f\u75be\u75c5\u751f\u7269\u5b66\u7814\u7a76\u548c\u57fa\u7840\u53d1\u73b0\uff0c\u4e34\u5e8a\u5b9e\u8df5\u5f97\u5230\u6539\u5584\u3002\u5177\u4f53\u5730\uff0c\u6d4b\u5e8f\u6280\u672f\u548c\u7cfb\u7edf\u7684\u53d1\u5c55\u4f7f\u5f97\u764c\u75c7\u7684\u5206\u5b50\u3001\u7ec6\u80de\u548c\u57fa\u56e0\u7ec4\u590d\u6742\u6027\u5f97\u5230\u4e86\u7a7a\u524d\u7684\u89e3\u51b3\u3002\u5927\u6570\u636e\u6280\u672f\u5df2\u9769\u65b0\u79d1\u7814\u4eba\u5458\u7684\u7684\u5de5\u4f5c\u65b9\u5f0f\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u56e0\u6b64\uff0cNature Cancer \u91c7\u8bbf\u4e86\u5168\u7403\u5341\u4f4d\u7814\u7a76\u764c\u75c7\u7684\u77e5\u540d\u79d1\u5b66\u5bb6\uff0c\u4ece\u4e0d\u540c\u89d2\u5ea6\u9610\u8ff0\u5173\u4e8e\u5404\u81ea\u9886\u57df\u7684\u4e3b\u8981\u53d1\u5c55\u60c5\u51b5\u4ee5\u53ca\u4ed6\u4eec\u5bf9\u764c\u75c7\u7684\u4e0b\u4e00\u4e2a\u7a81\u7834\u7684\u5c55\u671b\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u4ed6\u4eec\u90fd\u5f3a\u8c03\u4e86\u65b0\u5174\u79d1\u6280\u7684\u4f5c\u7528\u4ee5\u53ca\u8de8\u5b66\u79d1\u534f\u4f5c\u7684\u4ef7\u503c\uff0c\u65e0\u8bba\u662f\u5728\u7814\u7a76\u673a\u5236\u548c\u98ce\u9669\u56e0\u7d20\uff0c\u8fd8\u662f\u6539\u5584\u4e34\u5e8a\u8bca\u7597\u65b9\u9762\u3002<\/div>\n<div>\u00a0<\/div>\n<div>1. Ren\u00e9 Bernards\uff1a\u764c\u7ec6\u80de\u7684\u83b7\u5f97\u6027\u8106\u5f31<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBTKj3My4SaByXWnpbOxdAB6aWPibRy9XLJicx7rzc7Fdz1zK8Y8jFSoUWrBGOKBib9qhu9RGfSlHTCA.png\" alt=\"RmFicvQBAkgBTKj3My4SaByXWnpbOxdAB6aWPibRy9XLJicx7rzc7Fdz1zK8Y8jFSoUWrBGOKBib9qhu9RGfSlHTCA\"\/><\/figure><\/div>\n\n<\/div>\n<div>Ren\u00e9 Bernards\uff08\u8377\u5170\uff09<\/div>\n<div>\u8377\u5170\u764c\u75c7\u7814\u7a76\u6240\uff0cOncode\u7814\u7a76\u6240<\/div>\n<div>\uff08\u56fe\/Nature Cancer\uff09<\/div>\n<div>\u8bb8\u591a\u6297\u764c\u65b0\u836f\u90fd\u662f\u9776\u5411\u81f4\u764c\u9a71\u52a8\u56e0\u5b50\u2014\u2014\u81f4\u4f7f\u764c\u57fa\u56e0\u53d8\u5f97\u5f02\u5e38\u6d3b\u8dc3\u7684\u7a81\u53d8\u3002\u4f46\u5bb9\u6613\u53d1\u73b0\u7684\u764c\u75c7\u9776\u6807\u57fa\u56e0\u51e0\u4e4e\u88ab\u7528\u5b8c\u4e86\uff0c\u65b0\u836f\u7814\u53d1\u7684\u4e0b\u4e00\u8def\u5e94\u8be5\u600e\u4e48\u8d70\uff1f<\/div>\n<div><\/div>\n<div>\u7531\u4e8e\u764c\u75c7\u9009\u62e9\u6027\u7684\u7a81\u53d8\u4f1a\u5bfc\u81f4\u83b7\u5f97\u6027\u8106\u5f31\uff08acquired vulnerability\uff09\uff0c\u8fdb\u800c\u53ef\u4ee5\u57fa\u4e8e\u6b64\u8fdb\u884c\u836f\u7269\u7814\u53d1\u3002\u4e5f\u5c31\u662f\uff0c\u539f\u6765\u4e0d\u80fd\u7528\u4e8e\u65b0\u836f\u7814\u53d1\u7684\u764c\u75c7\u9776\u6807\u53ef\u4ee5\u95f4\u63a5\u5730\u9776\u5411\u764c\u75c7\u3002\u5145\u5206\u5229\u7528\u8fd9\u70b9\uff0c\u65b0\u836f\u7814\u53d1\u5c06\u8fdb\u5165\u4e00\u4e2a\u65b0\u7684\u7eaa\u5143\u3002<\/div>\n<div><\/div>\n<div>\u4e3e\u4e00\u4e2a\u548c\u4e34\u5e8a\u76f8\u5173\u7684\u77e5\u540d\u4f8b\u5b50\uff0c\u5373\uff0c\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0BRCA1\u6216BRCA2\u57fa\u56e0\u7f3a\u5931\u4f1a\u5bfc\u81f4\u5bf9\u805a\u4e8c\u78f7\u9178\u6838\u7cd6\u805a\u5408\u9176\u6291\u5236\u5242\u7684\u654f\u611f\u6027\u589e\u52a0\u3002\u540c\u6837\uff0c\u901a\u8fc7\u81f4\u4f7f\u529f\u80fd\u4e27\u5931\u7684\u57fa\u56e0\u7b5b\u67e5\u5df2\u7ecf\u53d1\u73b0\u4e86\u201c\u836f\u7269-\u836f\u7269\u5408\u6210-\u81f4\u6b7b\u201d\u76f8\u4e92\u4f5c\u7528\u7684\u6210\u679c\uff0c\u5176\u4e2d\u4e00\u4e9b\u5df2\u79bb\u4e34\u5e8a\u5e94\u7528\u4e0d\u8fdc\u3002\u53d7\u9650\u6027\u5728\u4e8e\u67d0\u4e9b\u836f\u7269\u6bd2\u6027\u592a\u5927\u800c\u65e0\u6cd5\u5728\u4e34\u5e8a\u4e0a\u6709\u6548\uff0c\u53ea\u80fd\u9010\u6b65\u7ed9\u4e88\u836f\u7269\u6cbb\u7597\u3002<\/div>\n<div><\/div>\n<div>\u540c\u65f6\uff0c\u7531\u4e8e\u80bf\u7624\u4e2d\u56fa\u6709\u7684\u5f02\u8d28\u6027\u6240\u81f4\uff0c\u5bf9\u764c\u75c7\u836f\u7269\uff08\u7684\u7ec4\u5408\uff09\u7684\u8010\u836f\u6027\u4e00\u76f4\u662f\u63a7\u5236\u764c\u75c7\u7684\u6700\u5927\u969c\u788d\u3002\u5f53\u764c\u7ec6\u80de\u5bf9\u6cbb\u7597\u4ea7\u751f\u8010\u836f\u6027\u65f6\uff0c\u4e0d\u4ec5\u5e26\u6765\u989d\u5916\u7684\u533b\u7597\u6210\u672c\uff0c\u4e5f\u5e26\u6765\u83b7\u5f97\u6027\u8106\u5f31\uff0c\u53ef\u4ee5\u4f5c\u4e3a\u65b0\u7684\u9776\u6807\u3002\u8fd9\u79cd\u83b7\u5f97\u6027\u8010\u836f\u7ec6\u80de\u7684\u8106\u5f31\u6027\u4e5f\u79f0\u4e3a\u201c\u9644\u5e26\u654f\u611f\u6027\u201d\uff08collateral sensitivity\uff09\u3002\u4f8b\u5982\uff0cBRAF\u7a81\u53d8\u7684\u9ed1\u7d20\u7624\u7ec6\u80de\u5bf9BRAF\u548cMEK\u7684\u9009\u62e9\u6027\u6291\u5236\u5242\u7684\u6297\u6027\uff0c\u4f34\u968f\u7740\u5bf9\u7ec4\u86cb\u767d\u8131\u4e59\u9170\u57fa\u9176\u6291\u5236\u5242\u7684\u83b7\u5f97\u6027\u8106\u5f31\u3002<\/div>\n<div><\/div>\n<div>\u4e00\u4e2a\u91cd\u8981\u7684\u89c2\u70b9\u662f\uff0c\u5bf9\u6cbb\u7597\u7684\u8010\u53d7\u6027\u901a\u5e38\u4e0d\u662f\u5728\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u83b7\u5f97\u7684\uff0c\u800c\u662f\u5728\u80bf\u7624\u4e2d\u9884\u5148\u5b58\u5728\u7684\u3002\u8010\u53d7\u6027\u901a\u5e38\u9075\u5faa\u53ef\u9884\u6d4b\u7684\u9014\u5f84\uff0c\u4f8b\u5982\u4f34\u968fEGFR\u7a81\u53d8\u7684\u80ba\u764c\uff0c\u88ab\u90e8\u5206EGFR\u6291\u5236\u5242\u9776\u5411\u6cbb\u7597\u3002<\/div>\n<div><\/div>\n<div>\u4e0e\u5176\u7b49\u5f85\u6b64\u7c7b\u8010\u836f\u6027\u80bf\u7624\u7ec6\u80de\u51fa\u73b0\u5e76\u6210\u4e3a\u80bf\u7624\u5757\u7684\u4e3b\u8981\u7ec4\u6210\u90e8\u5206\uff08\u5177\u6709\u76f8\u5173\u7684\u5f02\u8d28\u6027\uff09\uff0c\u4e0d\u5982\u5728\u5b9e\u9a8c\u5ba4\u7814\u7a76\u6b64\u7c7b\u8010\u836f\u6027\u7ec6\u80de\u7684\u540e\u5929\u8106\u5f31\u6027\u4ee5\u5f00\u53d1\u9488\u5bf9\u6027\u7684\u836f\u7269\u3002\u4e0e\u5176\u5728\u8010\u53d7\u529b\u53d1\u5c55\u4e4b\u540e\u5904\u7406\u540e\u5929\u7684\u8106\u5f31\u6027\uff0c\u4e0d\u5982\u8bf4\u662f\u901a\u8fc7\u201c\u5148\u53d1\u5236\u4eba\u7684\u6253\u51fb\u201d\u6765\u9884\u5148\u8017\u5c3d\u8fd9\u4e9b\u7ec6\u80de\u3002\u5176\u4f59\u7684\u80bf\u7624\u7ec6\u80de\u5e94\u8be5\u66f4\u540c\u8d28\u5316\uff0c\u56e0\u6b64\u5e94\u8be5\u5bf9\u9776\u5411\u539f\u59cb\u8106\u5f31\u6027\u7684\u836f\u7269\u6709\u66f4\u597d\u7684\u53cd\u5e94\u3002<\/div>\n<div><\/div>\n<div>\u968f\u7740\u6211\u4eec\u5bf9\u764c\u7ec6\u80de\u9057\u4f20\u673a\u5236\u7684\u66f4\u591a\u4e86\u89e3\uff0c\u6211\u4eec\u53ef\u4ee5\u53d1\u73b0\u764c\u7ec6\u80de\u7684\u6700\u8106\u5f31\u7684\u5730\u65b9\u5e76\u4e00\u51fb\u5373\u4e2d\u3002<\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<div>2. Elizabeth Jaffee\uff1a\u514d\u75ab\u6cbb\u7597\u5df2\u6210\u719f<\/div>\n<div><\/div>\n<div><\/div>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBTKj3My4SaByXWnpbOxdABWFmYYPzKFRNe6EgCEFUm0IZZ43yNd4nRBvJibX7ZJOz5eJjvrqo0rFA.png\" alt=\"RmFicvQBAkgBTKj3My4SaByXWnpbOxdABWFmYYPzKFRNe6EgCEFUm0IZZ43yNd4nRBvJibX7ZJOz5eJjvrqo0rFA\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">Elizabeth Jaffee\uff08\u7f8e\u56fd\uff09<\/div>\n<div style=\"text-align: center;\">\u7f8e\u56fd\u7ea6\u7ff0\u970d\u666e\u91d1\u65af\u5927\u5b66\uff0cSidney Kimmel\u764c\u75c7\u4e2d\u5fc3<\/div>\n<div style=\"text-align: center;\">\uff08\u56fe\/Nature Cancer\uff09<\/div>\n<div>\u514d\u75ab\u7597\u6cd5\u662f\u764c\u75c7\u6cbb\u7597\u4e2d\u516c\u8ba4\u7684\u6838\u5fc3\u65b9\u6cd5\u3002\u5728\u8fd9\u4e48\u77ed\u7684\u65f6\u95f4\u5185\uff0c\u5f88\u5c11\u6709\u7597\u6cd5\u80fd\u50cf\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u548c\u5de5\u7a0b\u5316T\u7ec6\u80de\u4e00\u6837\u5f15\u8d77\u4eba\u4eec\u7684\u5174\u594b\u3002<\/div>\n<div>\u7b2c\u4e00\u4e2a\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242ipilimumab\uff08\u4e00\u79cd\u6297CTLA-4\u5355\u6297\uff09\u4e8e2011\u5e74\u88abFDA\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\uff0c\u5386\u7ecf25\u5e74\u7684\u57fa\u7840\u79d1\u5b66\u53d1\u73b0\u4ee5\u53ca\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u5f00\u53d1\u3002\u4e09\u5e74\u540e\uff0cFDA\u8fc5\u901f\u6279\u51c6\u4e86\u9488\u5bf9PD-1\/PD-L1\u9014\u5f84\u7684\u6297\u4f53\u3002<\/div>\n<div>\u00a0<\/div>\n<div>2014\u5e74\u4ee5\u6765\uff0c\u8d85\u8fc730\u79cd\u9002\u5e94\u75c7\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5df2\u83b7\u5f97FDA\u6279\u51c6\uff0c\u5e76\u4e3a\u8bb8\u591a\u8f6c\u79fb\u7684\u764c\u75c7\u60a3\u8005\u63d0\u4f9b\u4e86\u66f4\u957f\u7684\u751f\u5b58\u7387\u3002\u800cCAR-T\u7597\u6cd5\u7684\u83b7\u6279\uff0c\u4e5f\u589e\u52a0\u4e86\u66f4\u591a\u6cbb\u7597\u764c\u75c7\u7684\u7279\u5f02\u6027\u514d\u75ab\u7597\u6cd5\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u5728\u6570\u5341\u5e74\u6ca1\u6709\u53d6\u5f97\u4e34\u5e8a\u8fdb\u5c55\u540e\u7684\u4eca\u5929\uff0c\u514d\u75ab\u6cbb\u7597\u53d6\u5f97\u4e86\u91cd\u5927\u7a81\u7834\u7684\u539f\u56e0\u5728\u4e8e\u57fa\u56e0\u7ec4\u5b66\u548c\u86cb\u767d\u8d28\u7ec4\u5b66\u6280\u672f\u7684\u8fdb\u6b65\u52a0\u5feb\u4e86\u9610\u660e\u514d\u75ab\u4fe1\u53f7\u901a\u8def\u7684\u901f\u5ea6\u3002\u5176\u6b21\uff0c\u5de5\u7a0b\u4eba\u6e90\u5316\u6539\u9020\u6297\u4f53\u548c\u5929\u7136\u4eba\u6e90\u6297\u4f53\u7684\u6280\u672f\u8fdb\u6b65\u52a0\u901f\u4e86\u8c03\u8282T\u7ec6\u80de\u4e0a\u7279\u5b9a\u514d\u75ab\u8c03\u8282\u4fe1\u53f7\u7684\u836f\u7269\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u963b\u65ad\u8fd9\u4e9b\u9014\u5f84\u7684\u6297\u4f53\u7684\u9996\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u4f7f\u7528\u7684\u662f\u4f20\u7edf\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\uff0c\u8bc4\u4f30\u4e86\u5bf9\u591a\u79cd\u80bf\u7624\u7684\u6bd2\u6027\u4e0e\u54cd\u5e94\u7387\uff0c\u800c\u6ca1\u6709\u8003\u8651\u80bf\u7624\u7684\u9057\u4f20\u6027\u548c\u708e\u75c7\u6210\u5206\u3002\u4f46\u662f\uff0c\u6700\u8fd1\u7684\u6280\u672f\u4e5f\u63a8\u52a8\u4e86\u9274\u5b9a\u80bf\u7624\u5185\u751f\u7269\u6807\u5fd7\u7269\uff0c\u4ee5\u53ca\u4ee5\u6b64\u9884\u6d4b\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u53cd\u5e94\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u81eaipilimumab\u83b7\u5f97\u6279\u51c6\u4ee5\u6765\uff0c\u5df2\u9274\u5b9a\u51fa\u4e24\u79cd\u751f\u7269\u6807\u5fd7\u7269\uff0c\u53ef\u4ee5\u7528\u6765\u9884\u6d4b\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff09\u4ee5\u53ca\u5bf9PD-1\/PD-L1\u7279\u5f02\u6027\u6291\u5236\u5242\uff08\u80bf\u7624\u7ec6\u80de\u4e0aPD-L1\u8868\u8fbe\u6c34\u5e73\uff09\u7684\u53cd\u5e94\u3002\u8fd9\u4e9b\u751f\u7269\u6807\u8bb0\u7269\u8fd8\u53ef\u8bc6\u522b\u7279\u5b9a\u7684\u9057\u4f20\u548c\u708e\u75c7\u6027\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\uff0c\u5df2\u7ecf\u7528\u4e8e\u9274\u5b9a\u6700\u53ef\u80fd\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u4ea7\u751f\u54cd\u5e94\u7684\u60a3\u8005\uff0c\u56e0\u6b64\u53ef\u4ee5\u907f\u514d\u5728\u4e0d\u592a\u53ef\u80fd\u4ea7\u751f\u54cd\u5e94\u7684\u60a3\u8005\u7684\u8eab\u4e0a\u53d1\u751f\u836f\u7269\u6bd2\u6027\u4e8b\u4ef6\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u540c\u6837\uff0c\u4e0b\u4e00\u4ee3\u6d4b\u5e8f\u6280\u672f\uff08NGS\uff09\u4e5f\u52a0\u5feb\u4e86\u80bf\u7624\u8868\u8fbe\u7684\u7279\u5b9a\u7a81\u53d8\u7684\u9274\u5b9a\uff0c\u63a8\u52a8\u5f00\u53d1\u75ab\u82d7\u548c\u57fa\u56e0\u5de5\u7a0b\u5316\u7684T\u7ec6\u80de\uff0c\u8fd9\u4e9b\u7b56\u7565\u5229\u7528\u60a3\u8005\u7279\u5f02\u6027\u7a81\u53d8\u6765\u63d0\u9ad8\u4e2a\u4f53\u60a3\u8005\u4e2d\u7a81\u53d8\u7279\u5f02\u6027T\u7ec6\u80de\u7684\u6570\u91cf\u548c\u8d28\u91cf\u3002<\/div>\n<div>\u65e9\u671f\u7684\u4e34\u5e8a\u8bd5\u9a8c\u663e\u793a\uff0c\u80bf\u7624\u60a3\u8005\u7279\u5b9a\u7684T\u7ec6\u80de\u65b9\u6cd5\u4e0e\u589e\u5f3aT\u7ec6\u80de\u6d3b\u6027\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7ed3\u5408\u4f7f\u7528\u65f6\uff0c\u6210\u529f\u6982\u7387\u66f4\u9ad8\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u7cbe\u51c6\u514d\u75ab\u6cbb\u7597\u7684\u672a\u6765\uff0c\u5c06\u7efc\u5408\u8003\u8651\u6bcf\u4e2a\u764c\u75c7\u60a3\u8005\u7684T\u7ec6\u80de\u7ec4\u6210\u548c\u514d\u75ab\u68c0\u67e5\u70b9\u73af\u5883\u3002\u540c\u65f6\uff0c\u5e94\u9f13\u52b1\u5728\u80bf\u7624\u53d1\u5c55\u65f6\u8fdb\u884c\u91cd\u590d\u7684\u6d3b\u68c0\uff0c\u4ee5\u89c2\u5bdf\u52a8\u6001\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u968f\u65f6\u95f4\u7684\u53d8\u5316\u3002\u540c\u65f6\u5141\u8bb8\u63a2\u7d22\u5feb\u901f\u8bbe\u8ba1\u5176\u4ed6T\u7ec6\u80de\u548c\u514d\u75ab\u68c0\u67e5\u70b9\u7597\u6cd5\uff0c\u4ee5\u4fbf\u5728\u5c06\u764c\u75c7\u53d8\u6210\u6162\u6027\u75c5\u7684\u60a3\u8005\u4e2d\u8fdb\u884c\u957f\u671f\u7684\u4e34\u5e8a\u62a4\u7406\u3002\u8fdb\u4e00\u6b65\u53d1\u5c55\u7684\u8bdd\uff0c\u8fd8\u9700\u8981\u5f00\u53d1\u9488\u5bf9\u751f\u7269\u6807\u5fd7\u7269\u7684\u975e\u4fb5\u5165\u6027\u6210\u50cf\u548c\u6db2\u4f53\u6d3b\u68c0\u5de5\u5177\uff0c\u8fd9\u4e9b\u5de5\u5177\u53ef\u7528\u4e8e\u9884\u6d4bTME\u7684\u65e9\u671f\u53d8\u5316\u5e76\u5141\u8bb8\u5fae\u8c03\u60a3\u8005\u5bf9\u7279\u5f02\u6027T\u7ec6\u80de\u7684\u53cd\u5e94\u3002<\/div>\n<div>\u00a0<\/div>\n<div>3. Johanna A.Joyce\uff1a\u80bf\u7624\u5fae\u73af\u5883<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBTKj3My4SaByXWnpbOxdABhfBS0prnOBtOsibkcGribQ41V95NvbLhoyDAuMMGOm7rXVELGwQQYEYg.png\" alt=\"RmFicvQBAkgBTKj3My4SaByXWnpbOxdABhfBS0prnOBtOsibkcGribQ41V95NvbLhoyDAuMMGOm7rXVELGwQQYEYg\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">Johanna A.Joyce\u00a0\uff08\u745e\u58eb\uff09<\/div>\n<div style=\"text-align: center;\">\u745e\u58eb\u8def\u5fb7\u7ef4\u5e0c\u764c\u75c7\u7814\u7a76\u6240\uff0c\u6d1b\u6851\u5927\u5b66<\/div>\n<div style=\"text-align: center;\">\uff08\u56fe\/Nature Cancer\uff09<\/div>\n<div>\u8fd1\u5e74\u6765\uff0c\u6211\u4eec\u5bf9\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u7684\u4e86\u89e3\u5448\u6307\u6570\u7ea7\u589e\u957f\uff0c\u5e76\u4e14\u7531\u4e8e\u4fe1\u606f\u91cf\u4e4b\u5927\u4f7f\u5f97\u89e3\u51b3TME\u7684\u590d\u6742\u6027\u770b\u8d77\u6765\u4ee4\u4eba\u96be\u4ee5\u7f6e\u4fe1\u3002\u5728TME\u7814\u7a76\u7684\u521d\u671f\uff0c\u4e5f\u8bb8\u6709\u4e00\u79cd\u8fc7\u5206\u4e50\u89c2\u7684\u89c2\u70b9\uff0c\u5373\u57fa\u4e8e\u9776\u5411TME\u4e2d\u6cbb\u7597\u53ef\u80fd\u4ee3\u8868\u4e00\u79cd\u6cdb\u764c\u79cd\u3001\u6cdb\u5668\u5b98\u7684\u201c\u5343\u7bc7\u4e00\u5f8b\u201d\u7684\u65b9\u6cd5\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u5f53\u7136\uff0c\u6211\u4eec\u73b0\u5728\u4e86\u89e3\uff0c\u867d\u7136\u53ef\u80fd\u5b58\u5728\u6784\u6210TME\u7684\u4e00\u7ec4\u901a\u7528\u7ec6\u80de\u7c7b\u578b\uff08\u5148\u5929\u548c\u9002\u5e94\u6027\u514d\u75ab\u7ec6\u80de\uff0c\u8840\u6db2\u548c\u6dcb\u5df4\u7ba1\u7f51\u7edc\uff0c\u57fa\u8d28\u7ec6\u80de\u548c\u764c\u7ec6\u80de\u672c\u8eab\uff09\uff0c\u4f46\u5177\u4f53\u7684\u7ec4\u6210\u6210\u5206\u548c\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u201c\u6b8b\u57fa\u201d\u53ef\u80fd\u4f1a\u56e0\u764c\u75c7\u53d1\u751f\u7684\u5668\u5b98\u800c\u6709\u5f88\u5927\u4e0d\u540c\u3002\u4e3e\u4e00\u4e2a\u5f88\u5177\u4ee3\u8868\u6027\u7684\u4f8b\u5b50\uff0c\u5728\u8111\u80bf\u7624\u4e2d\uff0c\u4e0d\u4ec5\u5b58\u5728\u5bf9TME\u81f3\u5173\u91cd\u8981\u7684\u7ec4\u7ec7\u7279\u5f02\u6027\u7ec6\u80de\u7c7b\u578b\uff0c\u5305\u62ec\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u3001\u5c0f\u80f6\u8d28\u7ec6\u80de\u548c\u795e\u7ecf\u5143\uff0c\u800c\u4e14\u8fd8\u6709\u72ec\u7279\u7684\u4fdd\u62a4\u6027\u8840\u8111\u5c4f\u969c\u7ed3\u6784\uff0c\u63a7\u5236\u7ec6\u80de\u548c\u836f\u7269\u8fdb\u5165\u5927\u8111\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u4e0d\u80fd\u7b80\u5355\u5730\u5c06\u4e00\u4e2a\u764c\u75c7\u5fae\u73af\u5883\u7684\u53d1\u73b0\u63a8\u65ad\u5230\u53e6\u4e00\u4e2a\u764c\u75c7\u5fae\u73af\u5883\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u4e1a\u5185\u53e6\u4e00\u79cd\u89c2\u70b9\u662f\uff0c\u9664\u4e86\u4e0d\u540c\u7684\u5668\u5b98\u5dee\u522b\u5916\uff0c\u5373\u4f7f\u5728\u76f8\u540c\u7684\u7ec4\u7ec7\u7c7b\u578b\u5185\uff0c\u4e0d\u540c\u7684\u9057\u4f20\u9a71\u52a8\u56e0\u5b50\u5728\u4fee\u9970TME\u65b9\u9762\u4e5f\u53d1\u6325\u4e0d\u540c\u7684\u4f5c\u7528\u3002<\/div>\n<div>\u6b64\u5916\uff0c\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\uff0c\u751a\u81f3\u201c\u5fae\u73af\u5883\u4e2d\u7684\u5fae\u73af\u5883\u201d\u90fd\u663e\u793a\u51faTME\u7ec4\u6210\u3001\u8868\u578b\u548c\u529f\u80fd\u968f\u80bf\u7624\u4f4d\u7f6e\u800c\u5f02\u3002\u8003\u8651\u5230\u4e0d\u540cTME\u4e4b\u95f4\u7684\u590d\u6742\u6027\u548c\u591a\u6837\u6027\uff0c\u6211\u4eec\u5982\u4f55\u8bc6\u522b\u548c\u9776\u5411\u6cbb\u7597\u7684\u6700\u4f73\u5173\u952e\u7ec6\u80de\u7c7b\u578b\uff1f<\/div>\n<div>\u00a0<\/div>\n<div>\u5728\u8fc7\u53bb\u7684\u5341\u5e74\u4e2d\uff0c\u8bb8\u591a\u7814\u7a76\u8bd5\u56fe\u901a\u8fc7\u8bc4\u4f30\u4e00\u7cfb\u5217\u9776\u6807\u6765\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\uff0c\u5305\u62ec\u8840\u7ba1\u751f\u6210\u8109\u7ba1\u7cfb\u7edf\uff0c\u6210\u7ea4\u7ef4\u7ec6\u80de\u548c\u57fa\u8d28\u76f8\u5173\u8fc7\u7a0b\uff0c\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\u7b49\uff0c\u8fc4\u4eca\u4e3a\u6b62\u6700\u6210\u529f\u7684\u4f8b\u5b50\u662f\u589e\u5f3aTME\u4e2dT\u7ec6\u80de\u6d78\u6da6\u548c\/\u6216\u6d3b\u6027\u7684\u514d\u75ab\u7597\u6cd5\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u57fa\u4e8e\u514d\u75ab\u7684\u7597\u6cd5\u76ee\u524d\u4ec5\u5728\u4e00\u90e8\u5206\u764c\u75c7\u4e2d\u6709\u6548\uff0c\u800c\u9650\u5236\u5176\u529f\u6548\u7684\u4e3b\u8981\u673a\u5236\u662f\u514d\u75ab\u6291\u5236\u6027\u5fae\u73af\u5883\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u56e0\u6b64\uff0c\u672a\u6765\u7684\u9053\u8def\u4e2d\uff0c\u5728\u5f53\u524d\u7814\u7a76\u5355\u4e2a\u70ed\u70b9\u7ec6\u80de\u7c7b\u578b\u5916\uff0c\u9700\u6709\u5347\u7ea7\u81f3\u6db5\u76d6\u66f4\u5168\u9762\u7684\u7cfb\u7edf\u65b0\u65b9\u6cd5\uff0c\u6211\u4eec\u9700\u8981\u96c6\u6210\u6240\u6709TME\u6210\u5206\uff0c\u4f5c\u4e3a\u8bc6\u522b\u548c\u9776\u5411\u764c\u75c7\u5173\u952e\u8282\u70b9\u7684\u4e00\u79cd\u624b\u6bb5\u3002\u6211\u4eec\u8fd8\u9700\u8981\u8ba4\u8bc6\u5230\uff0cTME\u662f\u4e00\u4e2a\u79fb\u52a8\u7684\u9776\u6807\uff0c\u4e0d\u4ec5\u5728\u80bf\u7624\u8fdb\u5c55\u8fc7\u7a0b\u4e2d\u800c\u4e14\u5728\u6cbb\u7597\u5e72\u9884\u540e\u4e5f\u4f1a\u53d1\u751f\u53d8\u5316\u3002\u56e0\u6b64\uff0c\u9700\u8981\u5c06TME\u7684\u52a8\u6001\u5206\u6790\uff08\u4f8b\u5982\u901a\u8fc7\u6d3b\u4f53\u6210\u50cf\u3001\u6216\u7ed3\u5408\u8fde\u7eed\u7684\u7ec4\u7ec7\u6d3b\u68c0\u53ca\u5355\u7ec6\u80de\u7ec4\u5b66\uff09\u6574\u5408\u5230\u6211\u4eec\u7684\u5b9e\u9a8c\u65b9\u6cd5\u4e2d\u3002<\/div>\n<div>\u6700\u540e\uff0c\u6211\u4eec\u5fc5\u987b\u6269\u5927\u5206\u6790\u8303\u56f4\uff0c\u5bf9\u60a3\u8005\u8fdb\u884c\u6574\u4f53\u68c0\u67e5\uff0c\u4ee5\u4e86\u89e3\u5168\u8eab\u6027\u75be\u75c5\uff08\u4f8b\u5982\u80a5\u80d6\uff0c\u6076\u75c5\u8d28\uff0c\u708e\u75c7\u548c\u8870\u8001\uff09\u5982\u4f55\u5f71\u54cdTME\u548c\u6cbb\u7597\u53cd\u5e94\u3002<\/div>\n<div>\u00a0<\/div>\n<div>4. Scott W.Lowe\uff1a\u4e0b\u4e00\u4ee3\u5de5\u7a0b\u5c0f\u9f20\u6a21\u578b<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBTKj3My4SaByXWnpbOxdABc3wWABWalfOQJr4ibwnyQXgn2IMSwPAibwWHNmeqjEPd07QiabktbgXfw.png\" alt=\"RmFicvQBAkgBTKj3My4SaByXWnpbOxdABc3wWABWalfOQJr4ibwnyQXgn2IMSwPAibwWHNmeqjEPd07QiabktbgXfw\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">Scott W. Lowe\uff08\u7f8e\u56fd\uff09<\/div>\n<div style=\"text-align: center;\">\u7ebd\u7ea6\u65af\u9686\u00b7\u51ef\u7279\u7433\u7eaa\u5ff5\u764c\u75c7\u4e2d\u5fc3\uff0c\u65af\u9686\u00b7\u51ef\u7279\u7433\u7814\u7a76\u6240<\/div>\n<div style=\"text-align: center;\">\u970d\u534e\u5fb7\u00b7\u4f11\u65af\u533b\u5b66\u7814\u7a76\u6240\uff0c\u764c\u75c7\u751f\u7269\u5b66\u4e0e\u9057\u4f20\u5b66\u8ba1\u5212<\/div>\n<div style=\"text-align: center;\">\uff08\u56fe\/Nature Cancer\uff09<\/div>\n<div>\u4f20\u7edf\u7684\u57fa\u56e0\u5de5\u7a0b\u5c0f\u9f20\u6a21\u578b\uff08GEMM\uff09\u5df2\u88ab\u8bc1\u660e\u5bf9\u4e8e\u7406\u89e3\u764c\u75c7\u673a\u5236\u5177\u6709\u4e0d\u53ef\u4f30\u91cf\u7684\u4f5c\u7528\uff0c\u4f46\u5bf9\u764c\u75c7\u79d1\u7814\u8f6c\u5316\u7684\u63a8\u52a8\u8f83\u5c0f\u3002\u5bf9\u5e94\u7684\uff0c\u4eba\u7c7b\u764c\u75c7\u6765\u6e90\u7684\u7ec6\u80de\u7cfb\u79fb\u690d\u5230\u514d\u75ab\u529f\u80fd\u4f4e\u4e0b\u7684\u5c0f\u9f20\u4f53\u5185\u6240\u4ea7\u751f\u7684\u5f02\u79cd\u79fb\u690d\u6a21\u578b\uff0c\u5bf9\u8fd9\u65b9\u9762\u8fdb\u884c\u4e86\u8865\u5145\uff0c\u5c24\u5176\u662f\u5728\u9776\u6807\u9a8c\u8bc1\u548c\u836f\u7269\u8bc4\u4f30\u65b9\u9762\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u5c3d\u7ba1\u4eba\u7c7b\u80bf\u7624\u7684\u9057\u4f20\u7814\u7a76\u548c\u60a3\u8005\u6765\u6e90\u5f02\u79cd\u79fb\u690d\u7269\u7684\u4f7f\u7528\u5df2\u514b\u670d\u4e86\u5f02\u79cd\u79fb\u690d\u7269\u6a21\u578b\u7684\u67d0\u4e9b\u5c40\u9650\u6027\uff0c\u4f46\u5b83\u4eec\u4ecd\u7136\u5ffd\u7565\u4e86TME\u65b9\u9762\uff0c\u8fd9\u4e9b\u65b9\u9762\u662f\u80bf\u7624\u8fdb\u5c55\u548c\u6cbb\u7597\u53cd\u5e94\u7684\u5173\u952e\u51b3\u5b9a\u56e0\u7d20\u3002<\/div>\n<div>\u00a0<\/div>\n<div>GEMM\u4f5c\u4e3a\u4e00\u79cd\u751f\u7406\u5b66\u4e0a\u7684\u9009\u62e9\u6750\u6599\uff0c\u7f13\u6162\u3001\u7e41\u7410\u4e14\u6602\u8d35\uff0c\u7279\u522b\u662f\u9700\u8981\u5927\u91cf\u7684\u5c0f\u9f20\u6742\u4ea4\u624d\u80fd\u751f\u6210\u591a\u7b49\u4f4d\u57fa\u56e0\u7a81\u53d8\u5c0f\u9f20\u7684\u76f8\u5173\u5b9e\u9a8c\u7ec4\uff0c\u4f7f\u5f97\u529f\u80fd\u6027\u7814\u7a76\u53d8\u6162\u3002\u800c\u9488\u5bf9\u76ee\u6807\u9a8c\u8bc1\u7684\u7814\u7a76\u66f4\u5177\u6311\u6218\u6027\uff0c\u9700\u8981\u989d\u5916\u7684\u8bf1\u5bfc\u6027\u7b49\u4f4d\u57fa\u56e0\u6765\u6291\u5236\u65e2\u5b9a\u80bf\u7624\u4e2d\u7684\u76ee\u6807\uff0c\u7531\u4e8e\u4e0d\u53ef\u80fd\u4ea7\u751f\u8377\u7624\u5c0f\u9f20\uff08tumor-bearing mice\uff09\u7684\u540c\u6b65\u961f\u5217\uff0c\u56e0\u6b64\u4e34\u5e8a\u524d\u7814\u7a76\u4f7f\u5f97\u5f88\u5c11\u6709\u5b66\u672f\u6216\u5de5\u4e1a\u56e2\u961f\u6709\u8db3\u591f\u7684\u8010\u5fc3\u6216\u8d44\u6e90\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u5c3d\u7ba1\u5982\u6b64\uff0c\u65b0\u6280\u672f\u4f7f\u5f97GEMM\u66f4\u5bb9\u6613\u5b9e\u73b0\u3002\u8f6c\u5ea7\u5b50\u4ecb\u5bfc\u7684\u8f6c\u57fa\u56e0\u548cCRISPR\u2013Cas9\u4ecb\u5bfc\u7684\u57fa\u56e0\u7f16\u8f91\u53ef\u5feb\u901f\u4ea7\u751f\u4e0d\u540c\u7684\u9057\u4f20\u7ed3\u6784\uff0c\u800c\u65e0\u9700\u8017\u65f6\u7684\u79cd\u7cfb\u57fa\u56e0\u9776\u5411\u65b9\u6cd5\u3002\u8bf1\u5bfc\u578bshRNA\u8f6c\u57fa\u56e0\u901a\u8fc7\u4f7f\u80bf\u7624\u8d77\u59cb\u4e0e\u80bf\u7624\u7ef4\u6301\u8131\u94a9\u800c\u4fc3\u8fdb\u9776\u6807\u9a8c\u8bc1\uff1b\u76f4\u63a5\u7531\u591a\u7b49\u4f4d\u57fa\u56e0\u80da\u80ce\u5e72\u7ec6\u80de\u6216\u79bb\u4f53\u5de5\u7a0b\u5316\u7684\u7c7b\u5668\u5b98\u7cfb\u7edf\u4ea7\u751f\u7684\u6a21\u578b\uff0c\u53ef\u4ea7\u751f\u5e26\u6709\u9057\u4f20\u5b9a\u4e49\u7684\u80bf\u7624\u800c\u65e0\u9700\u5e7f\u6cdb\u7684\u83cc\u682a\u4ea4\u53c9\u7684\u5c0f\u9f20\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u4e00\u79cd\u6539\u53d8\u6e38\u620f\u89c4\u5219\u7684\u65b9\u6cd5\u662f\uff0c\u901a\u8fc7\u7528\u5de5\u7a0b\u5316\u4f53\u7ec6\u80de\u5c06\u764c\u75c7\u6613\u611f\u7684\u75c5\u53d8\u76f4\u63a5\u5f15\u5165\u7ec4\u7ec7\u3002\u901a\u8fc7\u75c5\u6bd2\u8f6c\u5bfc\u3001\u6d41\u4f53\u52a8\u529b\u5b66\u8f6c\u67d3\uff08\u7528\u4e8e\u809d\u810f\uff09\u6216\u7ec4\u7ec7\u7535\u7a7f\u5b54\uff0c\u5c06cDNA\u6216\u57fa\u56e0\u7f16\u8f91\u6784\u5efa\u4f53\u76f4\u63a5\u5f15\u5165\u5c11\u91cf\u7684\u4f53\u7ec6\u80de\u4e2d\u3002\u80bf\u7624\u5f97\u4ee5\u96c6\u4e2d\u53d1\u751f\u4e14\u5468\u56f4\u88ab\u6b63\u5e38\u7ec4\u7ec7\u5305\u56f4\uff0c\u53ef\u4ee5\u8f6c\u79fb\u81f3\u9002\u5f53\u90e8\u4f4d\uff0c\u4ece\u800c\u51c6\u786e\u5730\u6a21\u62df\u4eba\u7c7b\u80bf\u7624\u7684\u53d1\u751f\u548c\u53d1\u5c55\u3002\u540c\u65f6\uff0c\u8fd9\u79cd\u65b9\u6cd5\u5927\u5927\u51cf\u5c11\u4e86\u4e0e\u5e26\u6709\u5404\u79cd\u80da\u7cfb\u7b49\u4f4d\u57fa\u56e0\u7684\u80da\u7cfb\u83cc\u682a\u4ea4\u53c9\u6742\u4ea4\u7684\u65f6\u95f4\u3002\u6b64\u5916\uff0c\u53ef\u4ee5\u5728\u5177\u6709\u4e0d\u540c\u9057\u4f20\u80cc\u666f\u7684\u5c0f\u9f20\u4e2d\u5feb\u901f\u4ea7\u751f\u80bf\u7624\uff0c\u6781\u5927\u5730\u63a8\u52a8\u7814\u7a76\u80bf\u7624\u4e0e\u5bbf\u4e3b\u76f8\u4e92\u4f5c\u7528\u5bf9\u80bf\u7624\u53d1\u751f\u7684\u5f71\u54cd\u7684\u7814\u7a76\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u4f53\u7ec6\u80de\u5de5\u7a0b\u4f53\u8fd8\u6709\u5176\u4ed6\u4f18\u70b9\u3002\u5728\u751f\u6210\u961f\u5217\u540c\u65f6\uff0c\u76f8\u6bd4\u4f20\u7edf\u83cc\u682a\u4ea4\u53c9\u65e0\u6cd5\u60f3\u8c61\u7684\u65b9\u5f0f\u52a0\u901f\u5305\u62ec\u836f\u7269\u6d4b\u8bd5\u5728\u5185\u7684\u5404\u79cd\u5206\u6790\u3002\u800c\u4e14\uff0c\u8fd9\u4e9b\u7cfb\u7edf\u5177\u6709\u9ad8\u5ea6\u7684\u53ef\u79fb\u690d\u6027\uff0c\u53ea\u9700\u8981\u914d\u7f6e\u8d28\u7c92\u548c\u4e0d\u540c\u65b9\u6848\u5373\u53ef\u3002\u4e0e\u4f20\u7edf\u65b9\u6cd5\u76f8\u6bd4\uff0c\u4f53\u7ec6\u80de\u7ec4\u7ec7\u5de5\u7a0b\u53ef\u4ee5\u5c06\u764c\u75c7\u5efa\u6a21\u901f\u5ea6\u63d0\u9ad8\u4e00\u4e2a\u6570\u91cf\u7ea7\uff0c\u5e76\u4e14\u53ef\u4ee5\u51cf\u5c11\u52a8\u7269\u6570\u91cf\u548c\u6210\u672c\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>\u5f53\u7136\uff0c\u6ca1\u6709\u4efb\u4f55\u6a21\u578b\u7cfb\u7edf\u662f\u5b8c\u7f8e\u7684\uff0c\u4efb\u4f55\u975e\u4eba\u7c7b\u764c\u75c7\u6a21\u578b\u7684\u6700\u7ec8\u76f8\u5173\u6027\u548c\u5b9e\u7528\u6027\u5c06\u53d6\u51b3\u4e8e\u6240\u63d0\u51fa\u95ee\u9898\u7684\u6027\u8d28\u3002\u4f46\u4e0d\u53ef\u5426\u8ba4\u7684\u662f\uff0c\u975e\u80da\u7cfb\u5c0f\u9f20\u764c\u75c7\u6a21\u578b\u63d0\u4f9b\u4e86\u6781\u5177\u5efa\u8bbe\u6027\u7684\u53ef\u5b9e\u73b0\u7684\u5e73\u53f0\uff0c\u4fc3\u8fdb\u764c\u75c7\u57fa\u7840\u7814\u7a76\u548c\u548c\u8f6c\u5316\u7814\u7a76\u3002<\/div>\n<div>\u00a0<\/div>\n<div>5. Elaine R.Mardis\uff1a\u764c\u75c7\u591a\u7ec4\u5b66<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBTKj3My4SaByXWnpbOxdABibzNcVyOqIicAkRh8abibeHJicXIEJmjmr3hezOTC0aOlSuwXbiaBWEIAQw.png\" alt=\"RmFicvQBAkgBTKj3My4SaByXWnpbOxdABibzNcVyOqIicAkRh8abibeHJicXIEJmjmr3hezOTC0aOlSuwXbiaBWEIAQw\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">Elaine R.Mardis\uff08\u7f8e\u56fd\uff09<\/div>\n<div style=\"text-align: center;\">\u4fc4\u4ea5\u4fc4\u5dde\u7acb\u5927\u5b66\u533b\u5b66\u9662<\/div>\n<div style=\"text-align: center;\">\u7f8e\u56fd\u513f\u7ae5\u533b\u9662\u57fa\u56e0\u7ec4\u533b\u5b66\u7814\u7a76\u6240<\/div>\n<div style=\"text-align: center;\">\uff08\u56fe\/Nature Cancer\uff09<\/div>\n<div>\u8fc7\u53bb\u4e8c\u5341\u5e74\uff0c\u764c\u75c7\u57fa\u56e0\u7ec4\u5b66\u7684\u53d1\u73b0\u4e3a\u764c\u75c7\u53d1\u751f\u548c\u53d1\u5c55\u7684\u57fa\u56e0\u7ec4\u57fa\u7840\u5efa\u7acb\u4e86\u8fdb\u4e00\u6b65\u7684\u77e5\u8bc6\u5e93\u3002\u6bcf\u4e2a\u764c\u75c7\u60a3\u8005\u7684\u57fa\u56e0\u7ec4\u548c\u8868\u89c2\u57fa\u56e0\u7ec4\u7684\u4e2a\u6027\u5316\uff0c\u518d\u52a0\u4e0a\u8003\u8651\u80da\u7cfb\u548c\u4f53\u7ec6\u80de\uff0c\u4ece\u6839\u672c\u4e0a\u6539\u53d8\u4e86\u764c\u7ec6\u80de\u7684\u751f\u7269\u5b66\u7814\u7a76\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u751f\u7269\u6280\u672f\u548c\u4fe1\u606f\u6280\u672f\u7684\u7ed3\u5408\uff0c\u57fa\u4e8e\u6539\u9020\u4eba\u4f53\u81ea\u8eab\u7684\u514d\u75ab\u7cfb\u7edf\u6765\u9776\u5411\u764c\u7ec6\u80de\u5148\u8fdb\u7684\u7597\u6cd5\u867d\u7136\u53d6\u5f97\u5f15\u4eba\u6ce8\u76ee\u7684\u6210\u7ee9\uff0c\u4f46\u5b83\u4eec\u6240\u5f71\u54cd\u7684\u751f\u547d\u4ecd\u7136\u5f88\u5c11\uff0c\u4e14\u7ecf\u5e38\u4ea7\u751f\u8010\u836f\u6027\u3002\u8fd9\u5524\u8d77\u6211\u4eec\u5173\u6ce8\u57fa\u4e8e\u57fa\u56e0\u7ec4\u7684\u764c\u75c7\u7cbe\u51c6\u533b\u7597\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u9996\u5148\uff0c\u6211\u4eec\u5fc5\u987b\u627f\u8ba4\uff0c\u7b80\u5355\u7684\u201c\u57fa\u56e0-\u7a81\u53d8-\u6cbb\u7597\u201d\u7684\u7b80\u5355\u65b9\u7a0b\u5f0f\u7f3a\u4e4f\u9884\u6d4b\u6cbb\u7597\u9776\u70b9\u6240\u9700\u7684\u590d\u6742\u6027\u3002\u764c\u75c7\u201c\u5f97\u76ca\u4e8e\u201d\u4f17\u591a\u57fa\u56e0\u7ec4\u53d8\u5f02\u6765\u52a0\u5f3a\u751f\u7269\u5b66\u529f\u80fd\uff0c\u5bf9\u5e94\u7684\u4e5f\u9700\u8981\u8003\u8651\u4f17\u591a\u57fa\u56e0\u7a81\u53d8\u7684\u8106\u5f31\u6027\uff08vulnerability\uff09\u6765\u52a0\u4ee5\u6cbb\u7597\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u8fd9\u4e9b\u57fa\u56e0\u7ec4\u53d8\u5f02\u5305\u62ec\u57fa\u4e8e\u7532\u57fa\u5316\u548c\u7ec4\u86cb\u767d\u4fee\u9970\u7684\u8868\u89c2\u9057\u4f20\u53d8\u5316\uff0c\u8fd9\u4e9b\u53d8\u5316\u4e0d\u80fd\u4ec5\u901a\u8fc7DNA\u5e8f\u5217\u201c\u8bfb\u51fa\u201d\u3002\u800cRNA\u6d4b\u5e8f\u53ef\u4ee5\u68c0\u6d4b\u5305\u62ec\u57fa\u56e0\u7ec4\u548c\u8868\u89c2\u57fa\u56e0\u7ec4\u7684\u53d8\u5f02\uff0c\u4ee5\u53ca\u63d0\u9ad8\u836f\u7269\u6d3b\u52a8\u548c\u9776\u5411\u86cb\u767d\u8fc7\u8868\u8fbe\uff0cRNA\u6d4b\u5e8f\u6570\u636e\u7684\u53cd\u5377\u79ef\uff08deconvolution\uff09\u53ef\u63ed\u793a\u4e86\u764c\u75c7\u5fae\u73af\u5883\u7684\u7ec6\u8282\u65b9\u9762\uff0c\u4f8b\u5982\u6d78\u6da6\u514d\u75ab\u7ec6\u80de\u7684\u7c7b\u578b\u548c\u53ef\u9776\u5411\u68c0\u67e5\u70b9\u86cb\u767d\u7684\u8868\u8fbe\u6c34\u5e73\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u5176\u6b21\uff0c\u6211\u4eec\u5fc5\u987b\u5f00\u59cb\u5c06\u771f\u5b9e\u4e16\u754c\u6570\u636e\u4ee5\u53ca\u764c\u75c7\u7684\u9ad8\u7ea7\u57fa\u56e0\u7ec4\u56fe\u8c31\u6574\u5408\u5230\u6cbb\u7597\u51b3\u7b56\u4e2d\u3002\u8fd9\u79cd\u505a\u6cd5\u5c06\u89e3\u51b3\u4e00\u4e9b\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e0d\u8db3\uff0c\u4e3a\u764c\u75c7\u6cbb\u7597\u7684\u76d1\u7ba1\u5ba1\u6279\u63d0\u4f9b\u6570\u636e\u4f9d\u636e\u3002\u4f8b\u5982\uff0c\u9776\u5411\u7597\u6cd5\u7684\u4e34\u5e8a\u8bd5\u9a8c\u901a\u5e38\u4ec5\u9700\u8981\u7279\u5b9a\u57fa\u56e0\u7684\u7279\u5b9a\u7a81\u53d8\u5373\u53ef\u7eb3\u5165\u7814\u7a76\uff0c\u8fd9\u8fc7\u4e8e\u7b80\u5355\u3002\u800c\u771f\u5b9e\u4e16\u754c\u6570\u636e\u5c06\u5e2e\u52a9\u4e34\u5e8a\u8bd5\u9a8c\u62db\u52df\u6700\u5408\u9002\u7684\u764c\u75c7\u60a3\u8005\uff0c\u901a\u8fc7\u5728\u4e8c\u7ebf\u6216\u4e09\u7ebf\u6cbb\u7597\u4e2d\u7eb3\u5165\u90a3\u4e9b\u83b7\u5f97\u6279\u51c6\u6cbb\u7597\u7684\u60a3\u8005\u7684\u57fa\u56e0\u7ec4\u4fe1\u606f\u548c\u53cd\u5e94\u6570\u636e\uff0c\u53ef\u4ee5\u8fdb\u884c\u8c03\u6574\u4ece\u800c\u4f7f\u5f97\u60a3\u8005\u6bd4\u539f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u53cd\u5e94\u591a\u5c11\u4f1a\u66f4\u6301\u4e45\u7684\uff0c\u4e5f\u53ef\u4ee5\u66f4\u7075\u6d3b\u5730\u9884\u6d4b\u5bf9\u6cbb\u7597\u53cd\u5e94\u7684\u53d8\u5316\u7ec4\u5408\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u6700\u540e\uff0c\u6211\u4eec\u5fc5\u987b\u8ba4\u8bc6\u5230\uff0c\u6570\u636e\u5171\u4eab\u5c06\u4fc3\u8fdb\u5f62\u6210\u96c6\u4f53\u667a\u6167\u5e76\u6269\u5927\u7cbe\u51c6\u533b\u7597\u6709\u76ca\u4e8e\u6240\u6709\u764c\u75c7\u60a3\u8005\u8fd9\u4e00\u4e8b\u5b9e\u7684\u5f71\u54cd\u529b\uff0c\u6211\u4eec\u5fc5\u987b\u627e\u5230\u5171\u8bc6\uff0c\u5728\u8ba9\u5168\u4e16\u754c\u80bf\u7624\u6cbb\u7597\u670d\u52a1\u5546\u4e4b\u95f4\u5171\u4eab\u8fd9\u4e9b\u6570\u636e\u3002\u6839\u636e\u6211\u7684\u7ecf\u9a8c\uff0c\u8fd9\u662f\u764c\u75c7\u60a3\u8005\u53ca\u5176\u5bb6\u4eba\u6240\u5e0c\u671b\u7684\uff1a\u4e0d\u4ec5\u5177\u6709\u6f5c\u5728\u7684\u4e2a\u4eba\u5c0f\u6613\uff0c\u800c\u4e14\u8fd8\u5e2e\u52a9\u5176\u4ed6\u764c\u75c7\u60a3\u8005\u63d0\u4f9b\u6570\u636e\uff1b\u51e0\u4e4e\u6ca1\u6709\u592a\u591a\u7684\u6570\u636e\u9690\u79c1\u95ee\u9898\u3002<\/div>\n<div>\u00a0<\/div>\n<div>6. Sean J. Morrison\uff1a\u80bf\u7624\u53d1\u751f\u673a\u5236<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBTKj3My4SaByXWnpbOxdABs9RDnHNAhibd4PCCRYVUSIc8v2ddN9LcPXMI1gMKD12YWFPBSf2EIKQ.png\" alt=\"RmFicvQBAkgBTKj3My4SaByXWnpbOxdABs9RDnHNAhibd4PCCRYVUSIc8v2ddN9LcPXMI1gMKD12YWFPBSf2EIKQ\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">Sean J. Morrison\uff08\u7f8e\u56fd\uff09<\/div>\n<div style=\"text-align: center;\">\u970d\u534e\u5fb7\u00b7\u4f11\u65af\u533b\u5b66\u9662\uff0c\u5fb7\u514b\u8428\u65af\u5927\u5b66\u897f\u5357\u533b\u5b66\u4e2d\u5fc3<\/div>\n<div style=\"text-align: center;\">\uff08\u56fe\/Nature Cancer\uff09<\/div>\n<div>\u5927\u591a\u6570\u83b7\u5f97\u76ee\u524d\u770b\u8d77\u6765\u53ef\u4ee5\u5f15\u8d77\u764c\u75c7\u7684\u7a81\u53d8\u7684\u7ec6\u80de\u4e0d\u4f1a\u5f15\u8d77\u764c\u75c7\u3002\u76f8\u53cd\uff0c\u5b83\u4eec\u7ecf\u5386\u7ec8\u672b\u5206\u5316\u3001\u8870\u8001\u6216\u6b7b\u4ea1\u3002\u56e0\u6b64\uff0c\u7a81\u53d8\u672c\u8eab\u662f\u4e0d\u591f\u7684\uff0c\u7ec6\u80de\u547d\u8fd0\u4e5f\u53d7\u8868\u89c2\u9057\u4f20\u548c\u4ee3\u8c22\u72b6\u6001\u4ee5\u53ca\u7ec4\u7ec7\u73af\u5883\u7684\u5f71\u54cd\u3002\u8fd9\u4e9b\u975e\u9057\u4f20\u673a\u5236\u5982\u4f55\u4ee5\u7ec6\u80de\u81ea\u4e3b\u65b9\u5f0f\u548c\u975e\u7ec6\u80de\u81ea\u4e3b\u65b9\u5f0f\u5f71\u54cd\u764c\u75c7\u7684\u53d1\u751f\uff0c\u4eba\u4eec\u5bf9\u6b64\u77e5\u4e4b\u751a\u5c11\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u4f8b\u5982\uff0c\u7ec6\u80de\u4e4b\u95f4\u4ee5\u53ca\u4eba\u4e0e\u4eba\u4e4b\u95f4\u7684\u4ee3\u8c22\u548c\u8425\u517b\u5dee\u5f02\u5728\u591a\u5927\u7a0b\u5ea6\u4e0a\u4fc3\u8fdb\u4e86\u764c\u75c7\u7684\u53d1\u9001\uff0c\u8fd9\u70b9\u6211\u4eec\u4e86\u89e3\u751a\u5c11\uff1b\u4f46\u4f53\u5185\u4ee3\u8c22\u7ec4\u5b66\u548c\u540c\u4f4d\u7d20\u793a\u8e2a\u6280\u672f\u7684\u6700\u65b0\u8fdb\u5c55\u5c06\u4f7f\u5b83\u6210\u4e3a\u672a\u676510\u5e74\u6700\u4ee4\u4eba\u6fc0\u52a8\u7684\u764c\u75c7\u751f\u7269\u5b66\u9886\u57df\u4e4b\u4e00\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u6700\u8fd1\u7684\u53e6\u4e00\u9879\u98a0\u8986\u6027\u53d1\u73b0\u662f\uff0c\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u548c\u6162\u6027\u7ec4\u7ec7\u635f\u4f24\uff0c\u5927\u591a\u6570\u6216\u6240\u6709\u518d\u751f\u7ec4\u7ec7\u4f3c\u4e4e\u53d8\u5f97\u66f4\u52a0\u514b\u9686\uff0c\u4e5f\u5c31\u662f\u8bf4\uff0c\u968f\u7740\u5e72\u7ec6\u80de\u548c\u7956\u7ec6\u80de\uff08progenitor cells \uff09\u83b7\u5f97\u7684\u7a81\u53d8\u514b\u9686\u660e\u663e\u9ad8\u4e8e\u90bb\u8fd1\u7ec6\u80de\u76f8\u6bd4\uff0c\u8fd9\u5df2\u7ecf\u5728\u8840\u6db2\u3001\u76ae\u80a4\u3001\u809d\u810f\u548c\u98df\u9053\u4e2d\u5f97\u5230\u4e86\u8bc1\u660e\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u7a81\u53d8\u514b\u9686\u5b58\u5728\uff0c\u4f46\u8fd8\u4e0d\u662f\u764c\u7ec6\u80de\u3002\u7a81\u53d8\u4f53\u514b\u9686\u5728\u518d\u751f\u7ec4\u7ec7\u4e2d\u7684\u79ef\u7d2f\u589e\u52a0\u4e86\u764c\u75c7\u968f\u540e\u53d1\u5c55\u7684\u53ef\u80fd\u6027\uff0c\u8f6c\u5316\u4e3a\u764c\u75c7\u7684\u6982\u5ff5\u5dee\u5f02\u5f88\u5927\uff0c\u53d6\u51b3\u4e8e\u7a81\u53d8\u4f53\u514b\u9686\u4e2d\u7684\u7a81\u53d8\u7c7b\u578b\u3002<\/div>\n<div>\u514b\u9686\u7cfb\u7edf\u7684\u8fdb\u5316\u5df2\u5728\u9020\u8840\u7cfb\u7edf\u4e2d\u5f97\u5230\u4e86\u6700\u5e7f\u6cdb\u7684\u7814\u7a76\u3002\u5728\u63a5\u53d7\u653e\u5c04\u7597\u6cd5\u548c\u67d0\u4e9b\u5316\u5b66\u7597\u6cd5\u6cbb\u7597\u7684\u4eba\u4ee5\u53ca70\u5c81\u4ee5\u4e0a\u7684\u60a3\u8005\u4e2d\uff0c\u666e\u904d\u89c2\u5bdf\u5230\u514b\u9686\u6027\u9020\u8840\u529f\u80fd\u3002\u4e00\u4e2a\u5173\u952e\u7684\u95ee\u9898\u662f\u5728\u5176\u4ed6\u518d\u751f\u7ec4\u7ec7\u4e2d\u662f\u5426\u540c\u6837\u5982\u6b64\u3002<\/div>\n<div>\u5316\u7597\u548c\u653e\u7597\u4f1a\u63a8\u52a8\u518d\u751f\u7ec4\u7ec7\u4e2d\u514b\u9686\u8fdb\u5c55\u5417\uff1f\u53c8\u6216\u8005\uff0c\u514b\u9686\u6027\u7684\u4ea7\u751f\u7531\u4e8e\u4e0d\u540c\u7ec4\u7ec7\u4e2d\u7684\u4e0d\u540c\u8bf1\u53d8\u5242\uff08\u9488\u5bf9\u76ae\u80a4\u7d2b\u5916\u7ebf\u3001\u9488\u5bf9\u809d\u810f\u7684\u6bd2\u6027\u836f\u7269\u3001\u9488\u5bf9\u98df\u9053\u7684\u5438\u70df\u548c\u996e\u9152\u7b49\uff09\u5f15\u8d77\u7684\u5417\uff1f<\/div>\n<div>\u00a0<\/div>\n<div>\u514b\u9686\u6027\u5bf9\u7ec4\u7ec7\u518d\u751f\u80fd\u529b\u7684\u5f71\u54cd\u662f\u4ec0\u4e48\uff1f\u5e74\u9f84\u5bf9\u8bf1\u53d8\u5242\u7684\u53cd\u5e94\u6709\u5f71\u54cd\u5417\uff1f\u5728\u9020\u8840\u7cfb\u7edf\u4e2d\uff0c\u514b\u9686\u6027\u7684\u53d1\u751f\u7387\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u5448\u51e0\u4f55\u589e\u957f\u3002\u5728\u66b4\u9732\u4e8e\u76f8\u540c\u7684\u8bf1\u53d8\u5242\u540e\uff0c\u8001\u5e74\u4eba\u7684\u7ec4\u7ec7\u662f\u5426\u6bd4\u5e74\u8f7b\u4eba\u7684\u7ec4\u7ec7\u66f4\u5bb9\u6613\u5f62\u6210\u7ade\u4e89\u6027\u7684\u514b\u9686\uff1f<\/div>\n<div>\u00a0<\/div>\n<div>\u5982\u679c\u8fd9\u4e9b\u95ee\u9898\u5f97\u5230\u91cd\u89c6\u548c\u7814\u7a76\uff0c\u5b83\u5c06\u5f15\u53d1\u6709\u5173\u5e74\u9f84\u5bf9\u8bf1\u53d8\u5242\u53cd\u5e94\u7684\u5f71\u54cd\u4ee5\u53ca\u9650\u5236\u7a81\u53d8\u4f53\u514b\u9686\u6269\u5c55\u7684\u673a\u5236\uff08\u5305\u62ec\u4e0e\u7ec6\u80de\u7ade\u4e89\u6709\u5173\u7684\u673a\u5236\uff09\u7684\u57fa\u672c\u95ee\u9898\u7684\u8ba8\u8bba\u3002\u5728\u63a5\u4e0b\u6765\u7684\u5341\u5e74\u4e2d\uff0c\u6700\u6fc0\u52a8\u4eba\u5fc3\u7684\u673a\u4f1a\u4e4b\u4e00\u5c06\u662f\u4e86\u89e3\u8bf1\u53d8\u5bf9\u7ec4\u7ec7\u4f53\u5185\u7a33\u6001\u548c\u764c\u75c7\u53d1\u751f\u7684\u5f71\u54cd\uff0c\u4ee5\u53ca\u5176\u5982\u4f55\u968f\u7740\u5e74\u9f84\u800c\u53d8\u5316\u3002<\/div>\n<div>\u00a0<\/div>\n<div>7. \u00a0Kornelia Polyak\uff1a\u80bf\u7624\u8f6c\u79fb\u7684\u7cfb\u7edf\u6027<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCFnfYfJ3Nt5wcun91jk7UBRy7Tl3r4wgeFqPrJgW7ic7wfDK88NhlOvryaPXGzmtudwWeicPm0sYrA.png\" alt=\"RmFicvQBAkgCFnfYfJ3Nt5wcun91jk7UBRy7Tl3r4wgeFqPrJgW7ic7wfDK88NhlOvryaPXGzmtudwWeicPm0sYrA\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">Kornelia Polyak\uff08\u7f8e\u56fd\uff09<\/div>\n<div style=\"text-align: center;\">\u8fbe\u7eb3-\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u6240<\/div>\n<div style=\"text-align: center;\">\uff08\u56fe\/Nature Cancer\uff09<\/div>\n<div>\u56e0\u4e3a\u8fdc\u5904\u8f6c\u79fb\u662f\u5bfc\u81f4\u5927\u591a\u6570\u764c\u75c7\u6b7b\u4ea1\u7684\u539f\u56e0\uff0c\u88ab\u8ba4\u4e3a\u662f\u80bf\u7624\u53d1\u5c55\u7684\u9876\u5cf0\uff0c\u79d1\u5b66\u5bb6\u4e00\u76f4\u79ef\u6781\u5bfb\u627e\u80bf\u7624\u8f6c\u79fb\u7684\u9a71\u52a8\u56e0\u7d20\uff0c\u9884\u6d4b\u54ea\u4e9b\u539f\u53d1\u80bf\u7624\u5c06\u4f1a\u8fdb\u5c55\uff08\u8f6c\u79fb\uff09\u4ee5\u53ca\u963b\u6b62\u8be5\u8fc7\u7a0b\u7684\u65b9\u6cd5\u3002<\/div>\n<div>\u76ee\u524d\u5f15\u8d77\u8f6c\u79fb\u7814\u7a76\u4e1a\u5185\u6fc0\u70c8\u8ba8\u8bba\u7684\u89c2\u70b9\uff0c\u662f\u53c2\u4e0e\u4e0a\u76ae\u5411\u95f4\u5145\u8d28\u8f6c\u5316\u7684\u7ec6\u80de\u72b6\u6001\u7684\u5404\u79cd\u57fa\u56e0\u548c\u7ec6\u80de\u72b6\u6001\u7684\u53ef\u5851\u6027\u53ef\u80fd\u662f\u8f6c\u79fb\u7ea7\u8054\u53cd\u5e94\u7684\u5173\u952e\u53c2\u4e0e\u8005\u3002<\/div>\n<div>\uff08\u53e6\u4e00\u65b9\u89c2\u70b9\u8ba4\u4e3a\uff09\u57fa\u4e8e\u80bf\u7624\u53d1\u751f\u662f\u8fbe\u5c14\u6587\u8fdb\u5316\u8fc7\u7a0b\uff0c\u80bf\u7624\u5927\u5c0f\u3001\u53ef\u9057\u4f20\u8868\u578b\u7279\u5f81\u7684\u7ec6\u80de\u5f02\u8d28\u6027\u548c\u4e3b\u8981\u80bf\u7624\u5fae\u73af\u5883\u7684\u62d3\u6251\u591a\u6837\u6027\u53ef\u80fd\u662f\u6700\u51c6\u786e\u9884\u6d4b\u8f6c\u79fb\u8fdb\u5c55\u56e0\u7d20\u548c\u9a71\u52a8\u529b\uff0c\uff08\u663e\u7136\uff09\u5927\u591a\u6570\u7814\u7a76\u8f6c\u79fb\u57fa\u56e0\u7684\u79d1\u5b66\u5bb6\u4eec\u53ef\u80fd\u4e0d\u63a5\u53d7\u8fd9\u79cd\u89c2\u70b9\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u6b64\u5916\uff0c\u514d\u75ab\u7cfb\u7edf\u662f\u5bf9\u6297\u80bf\u7624\u7ec6\u80de\u6269\u6563\u548c\u751f\u957f\u7684\u6700\u6709\u6548\u9632\u5fa1\u65b9\u6cd5\u4e4b\u4e00\u3002\u6765\u81ea\u591a\u4e2a\u5b9e\u9a8c\u5ba4\uff08\u5305\u62ec\u6211\u81ea\u5df1\u7684\u5b9e\u9a8c\u5ba4\uff09\u7684\u6700\u65b0\u6570\u636e\uff0c\u8bc1\u660e\u975e\u7ec6\u80de\u81ea\u4e3b\u56e0\u5b50\uff08\u901a\u8fc7\u8c03\u8282\u5c40\u90e8\u5fae\u73af\u5883\u6765\u9a71\u52a8\u539f\u53d1\u6027\u80bf\u7624\u751f\u957f\uff09\u4e5f\u7ef4\u6301\u80bf\u7624\u5185\u5f02\u8d28\u6027\u5e76\u5bf9\u514d\u75ab\u7cfb\u7edf\u4ea7\u751f\u7cfb\u7edf\u6027\u5f71\u54cd\u3002\u56e0\u6b64\uff0c\u975e\u7ec6\u80de\u81ea\u4e3b\u56e0\u5b50\uff08\u4f8b\u5982\uff0c\u5206\u6ccc\u7684\u86cb\u767d\u8d28\u548c\u5916\u6ccc\u4f53\uff09\u786e\u5b9e\u53ef\u80fd\u662f\u80bf\u7624\u8fdb\u5c55\uff08\u5305\u62ec\u8f6c\u79fb\uff09\u7684\u6700\u5173\u952e\u9a71\u52a8\u56e0\u7d20\u4e4b\u4e00\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u5f53\u7136\uff0c\u8fd9\u4e0d\u4f1a\u964d\u4f4e\u80bf\u7624\u5185\u9057\u4f20\u7684\u91cd\u8981\u6027\uff0c\u800c\u662f\u5c06\u5b83\u4eec\u7f6e\u4e8e\u4e0d\u540c\u7684\u89d2\u5ea6\u3002\u9057\u4f20\u53d8\u5f02\u548c\u57fa\u56e0\u7ec4\u4e0d\u7a33\u5b9a\u6027\u589e\u52a0\u7ec6\u80de\u72b6\u6001\u7684\u53ef\u80fd\u6027\u6570\u91cf\u3002\u8fd9\u4e9b\u53d8\u5316\u4e2d\u6709\u8bb8\u591a\u4e0e\u5206\u6ccc\u86cb\u767d\u7684\u8868\u8fbe\u6539\u53d8\u4ee5\u53ca\u7ec6\u80de\u57fa\u8d28\u548c\u7ec6\u80de\u95f4\u901a\u8baf\u76f8\u5173\u7684\u5176\u4ed6\u56e0\u7d20\u6709\u5173\u3002\u56e0\u6b64\uff0c\u5373\u4f7f\u5047\u5b9a\u7684\u7ec6\u80de\u81ea\u4e3b\u6027\u80bf\u7624\u9a71\u52a8\u56e0\u5b50\u4e5f\u53ef\u80fd\u5177\u6709\u975e\u7ec6\u80de\u81ea\u4e3b\u6027\u6548\u5e94\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u9057\u4f20\u5f02\u5e38\u7684\u764c\u7ec6\u80de\u5728\u5fae\u73af\u5883\u4e2d\uff08\u4f8b\u5982\u7531\u8870\u8001\u548c\u53d1\u708e\u4ea7\u751f\u7684\u5fae\u73af\u5883\uff09\u4e5f\u5177\u6709\u9002\u5e94\u6027\u4f18\u52bf\uff0c\u8fd9\u4f7f\u6b64\u7c7b\u7ec6\u80de\u5f97\u4ee5\u6269\u589e\u548c\u8fdb\u4e00\u6b65\u591a\u6837\u5316\u3002\u708e\u75c7\u8fd8\u901a\u8fc7\u4fc3\u8fdb\u8840\u7ba1\u751f\u6210\u548c\u514d\u75ab\u6291\u5236\u800c\u4fc3\u8fdb\u8f6c\u79fb\u6027\u6269\u6563\u548c\u751f\u957f\u3002<\/div>\n<div>\u56e0\u6b64\uff0c\u5206\u6790\u80bf\u7624\u8f6c\u79fb\u9700\u8981\u7cfb\u7edf\u6027\u89d2\u5ea6\uff0c\u7efc\u5408\u8003\u8651\u5bbf\u4e3b\u7684\u7279\u6027\uff08\u751f\u6b96\u7ec6\u80de\uff0c\u751f\u6d3b\u65b9\u5f0f\u56e0\u7d20\u548c\u80bf\u7624\u5f15\u8d77\u7684\u7cfb\u7edf\u6027\u53d8\u5316\uff09\u548c\u80bf\u7624\u7684\u7279\u6027\uff0c\u7efc\u5408\u6240\u6709\u4fe1\u606f\u5236\u5b9a\u8054\u5408\u6cbb\u7597\u7b56\u7565\u3002<\/div>\n<div>\u00a0<\/div>\n<div>8. Cynthia L. Sears\uff1a\u764c\u75c7\u4e0e\u5fae\u751f\u7269\u7ec4<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBTKj3My4SaByXWnpbOxdABptQOJiaZfHScjAWIUiclbJKqIbkfM0j5LKGiaZiadI9RWOxAM3iaHWXgictA.png\" alt=\"RmFicvQBAkgBTKj3My4SaByXWnpbOxdABptQOJiaZfHScjAWIUiclbJKqIbkfM0j5LKGiaZiadI9RWOxAM3iaHWXgictA\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">Cynthia L. Sears\uff08\u7f8e\u56fd\uff09<\/div>\n<div style=\"text-align: center;\">\u7ea6\u7ff0\u00b7\u970d\u666e\u91d1\u65af\u5927\u5b66\u533b\u5b66\u9662<\/div>\n<div style=\"text-align: center;\">\u5f6d\u535a-\u91d1\u6885\u5c14\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7814\u7a76\u6240\u548c\u533b\u5b66\u7cfb<\/div>\n<div style=\"text-align: center;\">\uff08\u56fe\/Nature Cancer\uff09<\/div>\n<div>\u5f97\u76ca\u4e8e\u4fbf\u6377\u3001\u8d8a\u6765\u8d8a\u4fbf\u5b9c\u7684\u6280\u672f\uff0c\u4f7f\u5f97\u6211\u4eec\u80fd\u591f\u8bc4\u4f30\u76ae\u80a4\u3001\u7caa\u4fbf\u548c15\u5e74\u524d\u7b2c\u4e00\u6b21\u53d1\u73b0\u7684\u7c98\u819c\u5fae\u751f\u7269\u7fa4\u4e2d\u5fae\u751f\u7269\u542b\u91cf\u548c\u6210\u5206\u3001\u7ed3\u6784\u548c\u529f\u80fd\uff0c\u7279\u522b\u5730\u5305\u62ec\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u3002\u8fd9\u65b9\u9762\u7684\u6570\u636e\u5df2\u6d69\u5982\u70df\u6d77\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u5728\u5c0f\u9f20\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u53d1\u73b0\u5fae\u751f\u7269\u7ec4\u9a71\u52a8\u6216\u6539\u53d8\u4e86\u8fc4\u4eca\u4e3a\u6b62\u7814\u7a76\u7684\u51e0\u4e4e\u6bcf\u4e2a\u751f\u7269\u6d3b\u52a8\u6216\u75be\u75c5\u72b6\u6001\u3002\u76f8\u53cd\uff0c\u5bf9\u4e8e\u4eba\u7c7b\u800c\u8a00\uff0c\u5c3d\u7ba1\u5fae\u751f\u7269\u7684\u5f71\u54cd\u53ef\u80fd\u5f88\u5f3a\uff0c\u4f46\u5b83\u5bf9\u4e8e\u5305\u62ec\u764c\u75c7\u5728\u5185\u75be\u75c5\u53d1\u751f\u548c\u53d1\u5c55\u7684\u5f71\u54cd\u4ecd\u5145\u6ee1\u4e0d\u786e\u5b9a\u6027\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u5305\u62ec\u764c\u75c7\u65b9\u9762\uff0c\u6211\u4eec\u77e5\u9053\uff0c\u5728\u5168\u7403\u8303\u56f4\u5185\u6709\u4ee3\u8868\u6027\u7684\u90e8\u5206\u764c\u75c7\u53d1\u751f\u8d77\u6e90\u4e8e\u5fae\u751f\u7269\u3002\u4f8b\u5982\uff0c\u809d\u7ec6\u80de\u764c\u662f\u7531\u4e59\u578b\u548c\u4e19\u578b\u809d\u708e\u75c5\u6bd2\u5f15\u8d77\u7684\u3002\u80c3\u764c\u662f\u7531\u5e7d\u95e8\u87ba\u6746\u83cc\u5f15\u8d77\u7684\uff0c\u8fd8\u6709\u4e00\u5c0f\u90e8\u5206\u662f\u7531\u7231\u6cfc\u65af\u5766-\u5df4\u5c14\u75b1\u75b9\u75c5\u6bd2\u5f15\u8d77\u7684\u3002\u9ed8\u514b\u5c14\u7ec6\u80de\u764c\u662f\u7531\u9ed8\u514b\u5c14\u75c5\u6bd2\u5f15\u8d77\u7684\u3002\u4e1c\u5357\u4e9a\u7684\u4e00\u90e8\u5206\u80c6\u7ba1\u764c\u5728\u6d41\u884c\u75c5\u5b66\u4e0a\u4e0e\u5438\u866b\uff08Clonorchis sinensis\u548cOpisthorchis viverrini\uff09\u7684\u6162\u6027\u611f\u67d3\u6709\u5173\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u597d\u5728\u8fd9\u4e9b\u662f\u5355\u79cd\u5fae\u751f\u7269\u9a71\u52a8\u7684\u80bf\u7624\uff0c\u81f3\u5c11\u770b\u8d77\u6765\u75be\u75c5\u53d1\u751f\u4e0d\u9700\u8981\u5fae\u751f\u7269\u7fa4\u843d\u3002\u540c\u65f6\u5e78\u8fd0\u7684\u662f\uff0c\u6cbb\u6108\u67d0\u4e9b\u5355\u4e00\u5fae\u751f\u7269\uff08\u4f8b\u5982\u4e19\u578b\u809d\u708e\u75c5\u6bd2\u6216\u5e7d\u95e8\u87ba\u6746\u83cc\uff09\u5f15\u8d77\u7684\u75be\u75c5\uff0c\u8db3\u4ee5\u663e\u8457\u51cf\u5c11\u764c\u75c7\u7684\u53d1\u751f\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u867d\u7136\u6211\u4eec\u5df2\u7ecf\u786e\u5b9a\u5927\u591a\u6570\u764c\u75c7\u7684\u201c\u5185\u5916\u201d\u80bf\u7624\u7fa4\u843d\u662f\u4e0d\u540c\u7684\uff0c\u4f46\u6211\u4eec\u5bf9\u81f4\u764c\u6027\u5fae\u751f\u7269\u548c\u7fa4\u843d\u672c\u8eab\uff0c\u4ee5\u53ca\u5b83\u4eec\u5bf9\u7279\u5b9a\u764c\u75c7\u7684\u80bf\u7624\u5fae\u73af\u5883\u5f71\u54cd\u7684\u673a\u5236\u4ecd\u7f3a\u4e4f\u4e86\u89e3\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u6b64\u5916\uff0c\uff08\u4e4b\u524d\u6211\u4eec\u8ba4\u4e3a\uff09\u5fae\u751f\u7269\u53ef\u80fd\u662f\u65c1\u89c2\u8005\uff0c\u4f46\u6765\u81ea\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u9886\u57df\u7684\u6570\u636e\u6b63\u6311\u6218\u8fd9\u79cd\u53ef\u80fd\u6027\u3002\u968f\u7740CRC\u5728\u5168\u7403\u8303\u56f4\u5185\u7684\u5174\u8d77\u4ee5\u53ca\u65e9\u53d1\u6027CRC\u7684\u51fa\u73b0\uff0c\u9700\u8981\u5c06\u5fae\u751f\u7269\u7ec4\u6570\u636e\u66f4\u53ef\u9760\u5730\u8f6c\u5316\u4e3a\u4eba\u7c7bCRC\u961f\u5217\uff08\u8fdb\u800c\u6269\u5c55\u4e3a\u5176\u4ed6\u764c\u75c7\u961f\u5217\uff09\uff0c\u6765\u4e86\u89e3\u67d0\u4e9b\u5fae\u751f\u7269\u6216\u7fa4\u843d\u662f\u5426\u53ef\u4ee5\u51cf\u5c11\u80bf\u7624\u53d1\u751f\u3001\u53d1\u5c55\u4ee5\u53ca\u57fa\u4e8e\u6b64\u9884\u9632\u764c\u75c7\uff0c\u8fd9\u4e9b\u65b9\u5f0f\u5305\u62ec\u63d0\u9ad8\u65e9\u671f\u75be\u75c5\u68c0\u6d4b\u6548\u7387\u3001\u6539\u53d8\u81f4\u764c\u5fae\u751f\u7269\u7ec4\u7b49\u7b49\u3002<\/div>\n<div>\u81f3\u4eca\uff0c\u4ec5\u6d4b\u5e8f\u7814\u7a76\u8fd8\u4e0d\u8db3\u4ee5\u63d0\u4f9b\u9884\u9632CRC\u7684\u8db3\u591f\u51c6\u786e\u7684\u7ed3\u679c\uff0c\u9700\u8981\u7ed3\u5408\u5fae\u751f\u7269\u53d1\u75c5\u673a\u5236\uff0c\u57fa\u56e0\u7ec4\u5b66\u3001\u4ee3\u8c22\u7ec4\u5b66\u548c\u5176\u4ed6\u9886\u57df\u7684\u7814\u7a76\u7ed3\u679c\u6765\u521b\u9020\u6027\u5730\u63a8\u8fdbCRC\u548c\u5176\u4ed6\u764c\u75c7\u7684\u9884\u9632\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u7814\u7a76\u5fae\u751f\u7269\u7ec4\u5982\u4f55\u5bfc\u81f4\u764c\u75c7\u53d1\u751f\u98ce\u9669\u3001\u53d1\u5c55\u3001\u8fdb\u5c55\u548c\u6cbb\u7597\u662f\u4e00\u4e2a\u5145\u6ee1\u673a\u4f1a\u7684\u9886\u57df\u3002\u6211\u4eec\u53ef\u4ee5\u901a\u8fc7\u8db3\u591f\u591a\u7684\u60a3\u8005\u548c\u5bf9\u7167\u6765\u53d1\u8868\u8bba\u6587\uff0c\u901a\u8fc7\u5236\u5b9a\u6807\u51c6\u6765\u8bc4\u4f30\u548c\u5c55\u793a\u5fae\u751f\u7269\u7ec4\u7814\u7a76\u6210\u679c\u3002\u00a0\u5f88\u591a\u7814\u7a76\u7ed3\u679c\uff0c\u662f\u57fa\u4e8e\u770b\u8d77\u6765\u76f8\u4f3c\u7684\u60a3\u8005\u6837\u672c\u548c\u4e0d\u540c\u5206\u6790\u5de5\u5177\u6765\u83b7\u5f97\uff0c\u5c3d\u7ba1\u4f7f\u7528\u4e86\u5c11\u91cf\u7684\u4e34\u5e8a\u5143\u6570\u636e\uff08metadata\uff09\u8fdb\u884c\u8bc4\u4f30\u3002\u56e0\u6b64\uff0c\u901a\u8fc7\u6bd4\u8f83\u6587\u732e\u627e\u51fa\u4e00\u79cd\u5fae\u751f\u7269\u7ec4\u7814\u7a76\u66f4\u7b80\u5355\u7684\u65b9\u6cd5\u5c06\u6709\u6240\u5e2e\u52a9\u3002\u00a0\u6211\u4eec\u70ed\u5207\u671f\u5f85\u5fae\u751f\u7269\u5b66\u5728\u4e34\u5e8a\u7684\u5e94\u7528\uff0c\u4ee5\u63a8\u52a8\u764c\u75c7\u7684\u9884\u9632\u548c\u6cbb\u7597\u3002<\/div>\n<div>\u00a0<\/div>\n<div>9. Karen H.Vousden\uff1a\u4ee3\u8c22\u548c\u5b9a\u5236\u996e\u98df<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBTKj3My4SaByXWnpbOxdABL6ZAKlb0LSZDPJ0saUlZKXM23hN9LHFogicwZibYk2QGfPk0wX6tibeFA.png\" alt=\"RmFicvQBAkgBTKj3My4SaByXWnpbOxdABL6ZAKlb0LSZDPJ0saUlZKXM23hN9LHFogicwZibYk2QGfPk0wX6tibeFA\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">Karen H.Vousden\uff08\u82f1\u56fd\uff09<\/div>\n<div style=\"text-align: center;\">\u4f26\u6566\u5f17\u6717\u897f\u65af\u00b7\u514b\u91cc\u514b\u7814\u7a76\u6240<\/div>\n<div style=\"text-align: center;\">\uff08\u56fe\/Nature Cancer\uff09<\/div>\n<div>\u5c3d\u7ba1\u57fa\u56e0\u7ec4\u5b66\u5df2\u5728\u6211\u4eec\u5bf9\u764c\u75c7\u7684\u7406\u89e3\u548c\u6cbb\u7597\u4e2d\u5360\u636e\u4e3b\u5bfc\u5730\u4f4d\uff0c\u4f46\u8fd1\u5e74\u6765\u5bf9\u764c\u75c7\u4ee3\u8c22\u91cd\u8981\u6027\u7684\u91cd\u65b0\u8ba4\u8bc6\u5f00\u8f9f\u7684\u63a2\u7d22\u8def\u5f84\u540c\u6837\u6fc0\u52a8\u4eba\u5fc3\u3002\u4e0a\u4e2a\u4e16\u7eaa\uff0c\u751f\u7269\u5316\u5b66\u5bb6\u5bf9\u4ee3\u8c22\u9014\u5f84\u8fdb\u884c\u4e86\u4f18\u96c5\u7ec6\u81f4\u7684\u63cf\u8ff0\uff0c\u4f7f\u6211\u4eec\u7ad9\u5728\u4e86\u5de8\u4eba\u7684\u80a9\u8180\u4e0a\uff0c\u57fa\u4e8e\u6b64\u4e86\u89e3\u5230\uff0c\u4ee3\u8c22\u8f6c\u5316\u63a8\u52a8\u6076\u6027\u80bf\u7624\u53d1\u5c55\u7684\u6240\u6709\u9636\u6bb5\uff0c\u7a81\u53d8\u6216\u8fc7\u8868\u8fbe\u7684\u4ee3\u8c22\u9176\u8868\u73b0\u51fa\u81f4\u764c\u6d3b\u6027\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u5168\u8eab\u6027\u4ee3\u8c22\u56e0\u5b50\u4e5f\u53ef\u4ee5\u4fc3\u8fdb\u764c\u75c7\u7684\u53d1\u5c55\u3002\u4ee4\u4eba\u7740\u8ff7\u7684\u662f\uff0c\u652f\u6491\u80bf\u7624\u53d1\u751f\u7684\u4ee3\u8c22\u91cd\u6392\u4e5f\u53ef\u80fd\u5e26\u6765\u4e00\u4e9b\u8106\u5f31\u6027\uff0c\u4f8b\u5982\u6709\u9650\u7684\u80bf\u7624\u7ec6\u80de\u9002\u5e94\u6027\u6216\u65b0\u7684\u53ef\u80fd\u6709\u6bd2\u7684\u4ee3\u8c22\u4ea7\u7269\u7684\u4ea7\u751f\uff0c\u8fd9\u4e9b\u53ef\u80fd\u6210\u4e3a\u6cbb\u7597\u7684\u76ee\u6807\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u6700\u4ee4\u4eba\u5174\u594b\u7684\u524d\u666f\u4e4b\u4e00\uff0c\u662f\u6539\u53d8\u5168\u8eab\u65b0\u9648\u4ee3\u8c22\u6216\u5168\u8eab\u8425\u517b\u6c34\u5e73\uff0c\u5c06\u901a\u8fc7\u9776\u5411\u80bf\u7624\u672c\u8eab\u6216\u5f15\u53d1\u5bbf\u4e3b\u53cd\u5e94\uff08\u4f8b\u5982\u514d\u75ab\u9632\u5fa1\uff09\u6765\u9a71\u52a8\u6216\u589e\u5f3a\u6cbb\u7597\u53cd\u5e94\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u5b9a\u5236\u996e\u98df\u7684\u8c03\u8282\u65b9\u6cd5\u5f88\u6709\u610f\u601d\uff0c\u7ed3\u5408\u4e86\u80bf\u7624\u7684\u9057\u4f20\u53d8\u5f02\u548c\u8d77\u6e90\u4ee5\u53ca\u6cbb\u7597\u4f5c\u7528\u673a\u5236\u7684\u7279\u5b9a\u996e\u98df\u8bbe\u8ba1\u3002\u5404\u79cd\u5404\u6837\u7684\u65b9\u6cd5\u6b63\u5728\u63a2\u7d22\uff0c\u4ece\u4f8b\u5982\u78b3\u6c34\u5316\u5408\u7269\u6216\u86cb\u767d\u8d28\u7b49\u67d0\u4e9b\u98df\u7269\u79cd\u7c7b\u7684\u5e7f\u6cdb\u9650\u5236\uff0c\u5230\u53bb\u9664\u6216\u751a\u81f3\u8865\u5145\u7279\u5b9a\u6c28\u57fa\u9178\u6216\u7cd6\u3002\u73b0\u5728\u8fd8\u5904\u4e8e\u521d\u671f\uff0c\u4f46\u662f\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d\uff0c\u5728\u63cf\u8ff0\u590d\u6742\u7684\u80bf\u7624-\u5bbf\u4e3b-\u6cbb\u7597\u76f8\u4e92\u4f5c\u7528\u65b9\u9762\u5f88\u5feb\u53d6\u5f97\u4e86\u8fdb\u5c55\u3002\u5b9a\u5236\u996e\u98df\u63a7\u5236\u6709\u53ef\u80fd\u589e\u5f3a\u5bf9\u4f20\u7edf\u7597\u6cd5\u548c\u9776\u5411\u7597\u6cd5\u7684\u53cd\u5e94\uff0c\u800c\u4e0d\u4f1a\u589e\u52a0\u836f\u7269\u5f15\u8d77\u7684\u6bd2\u6027\u3002\u540c\u6837\u91cd\u8981\u7684\u662f\uff0c\u5b9a\u5236\u996e\u98df\u65b9\u6848\u7684\u4e34\u5e8a\u5904\u65b9\u5c06\u4f7f\u764c\u75c7\u60a3\u8005\u81f3\u5c11\u53ef\u4ee5\u81ea\u4e3b\u63a7\u5236\u5176\u6cbb\u7597\u548c\u751f\u6d3b\u7684\u67d0\u4e9b\u65b9\u9762\u3002<\/div>\n<div>\u00a0<\/div>\n<div>10. \u5f20\u6cfd\u6c11\uff1a\u5355\u7ec6\u80de\u7814\u7a76\u6539\u53d8\u6e38\u620f\u89c4\u5219<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBTKj3My4SaByXWnpbOxdABic8CRaglX8XcJgicrkEaURaeR1cQAlqKeRPEuWcar61ibbMj4Ha7yLaibw.png\" alt=\"RmFicvQBAkgBTKj3My4SaByXWnpbOxdABic8CRaglX8XcJgicrkEaURaeR1cQAlqKeRPEuWcar61ibbMj4Ha7yLaibw\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u5f20\u6cfd\u6c11\uff08\u4e2d\u56fd\uff09<\/div>\n<div style=\"text-align: center;\">\u5317\u4eac\u5927\u5b66\u751f\u7269\u533b\u5b66\u524d\u6cbf\u521b\u65b0\u4e2d\u5fc3(BIOPIC)\uff0c\u5317\u4eac\u5927\u5b66\u751f\u547d\u79d1\u5b66\u5b66\u9662\uff0c\u5317\u4eac\u5927\u5b66\u524d\u6cbf\u4ea4\u53c9\u5b66\u79d1\u7814\u7a76\u9662\uff0c\u5317\u4eac\u5927\u5b66-\u6e05\u534e\u5927\u5b66\u751f\u547d\u79d1\u5b66\u8054\u5408\u4e2d\u5fc3<\/div>\n<div style=\"text-align: center;\">\uff08\u56fe\/Nature Cancer\uff09<\/div>\n<div>\u65e9\u671f\u7684\u764c\u75c7\u7814\u7a76\u96c6\u4e2d\u5728\u7ec6\u80de\u6c34\u5e73\u4e0a\u30021850\u5e74\u4ee3\uff0c\u9c81\u9053\u592b\u00b7\u7ef4\u5c14\u4e18\uff08Rudolf Virchow\uff09\u9996\u5148\u5c06\u764c\u7ec6\u80de\u7684\u8d77\u6e90\u4e0e\u6b63\u5e38\u7ec6\u80de\u8054\u7cfb\u8d77\u6765\uff0c\u8fd9\u5df2\u6210\u4e3a\u4eba\u4eec\u6700\u516c\u8ba4\u7684\u764c\u75c7\u7684\u5b9a\u4e49\uff1a\u4e00\u79cd\u7531\u7a81\u53d8\u7ec6\u80de\u5f15\u8d77\u7684\u3001\u8868\u73b0\u51fa\u4e0d\u53d7\u63a7\u5236\u7684\u589e\u6b96\u548c\u4fb5\u88ad\u6027\u7684\u75be\u75c5\u3002\u5728\u4ee5\u9057\u4f20\u5b66\u548c\u751f\u7269\u5316\u5b66\u4e3a\u57fa\u7840\u7684\u764c\u75c7\u7814\u7a76\u53d1\u5c55\u4e4b\u524d\uff0c\u57fa\u4e8e\u5f62\u6001\u5b66\u7684\u764c\u7ec6\u80de\u7814\u7a76\u5728\u6574\u4e2a\u9886\u57df\u5360\u636e\u4e86\u4e00\u4e2a\u591a\u4e16\u7eaa\u3002<\/div>\n<div>\u00a0<\/div>\n<div>1980\u5e74\u4ee3\uff0c\u7ec6\u80de\u901a\u8def\u7814\u7a76\u7684\u8fc5\u901f\u53d1\u5c55\uff0c\u6781\u5927\u63a8\u52a8\u764c\u75c7\u7814\u7a76\u7684\u8fdb\u5c55\u3002\u591a\u5e74\u6765\uff0c\u6211\u4eec\u5df2\u7ecf\u79ef\u7d2f\u4e86\u9a71\u52a8\u764c\u53d8\u3001\u8fdb\u5c55\u3001\u8f6c\u79fb\u548c\u5bf9\u6cbb\u7597\u4ea7\u751f\u8010\u836f\u6027\u7684\u57fa\u56e0\u7684\u7a7a\u524d\u77e5\u8bc6\uff0c\u5e76\u4e14\uff0c\u764c\u75c7\u7814\u7a76\u7684\u8303\u5f0f\u9010\u6e10\u4ece\u7ec6\u80de\u6c34\u5e73\u8f6c\u79fb\u5230\u4e86\u5206\u5b50\u6c34\u5e73\u3002\u5c3d\u7ba1\u6211\u4eec\u4ece\u4ee5\u5206\u5b50\u548c\u901a\u8def\u4e3a\u4e2d\u5fc3\u7684\u764c\u75c7\u7814\u7a76\u4e2d\u83b7\u5f97\u4e86\u4e30\u5bcc\u7684\u77e5\u8bc6\uff0c\u4f46\u662f\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\u5bf9\u764c\u75c7\u9014\u5f84\u7684\u7406\u89e3\u4e0e\u9884\u671f\u7684\u5e72\u9884\u89e3\u51b3\u65b9\u6848\u4e4b\u95f4\u4ecd\u7136\u5b58\u5728\u5de8\u5927\u5dee\u8ddd\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u751f\u7269\u5b66\u77e5\u8bc6\u4e0e\u6cbb\u7597\u8fdb\u5c55\u4e4b\u95f4\u5b58\u5728\u843d\u5dee\u7684\u53ef\u80fd\u539f\u56e0\u4e4b\u4e00\u662f\uff0c\u6211\u4eec\u4e60\u60ef\u4e8e\u6574\u4f53\u5bf9\u5f85\u4e34\u5e8a\u80bf\u7624\u6837\u54c1\uff0c\u6781\u529b\u53bb\u627e\u5230\u80bf\u7624\u4e2d\u5f02\u5e38\u7684\u901a\u8def\u4ee5\u53ca\u9776\u5411\u6cbb\u7597\u7684\u201c\u7075\u4e39\u5999\u836f\u201d\u3002\u5c3d\u7ba1\u8fd9\u4e00\u7406\u5ff5\u63a8\u52a8\u4e86\u9776\u5411\u7597\u6cd5\u7684\u53d1\u5c55\uff0c\u4f46\u5b83\u53ef\u80fd\u63a9\u76d6\u4e86\u4e0d\u540c\u7ec6\u80de\u4e2d\u53d1\u751f\u4e0d\u540c\u751f\u5316\u53cd\u5e94\u6216\u4fe1\u53f7\u4f20\u5bfc\u9014\u5f84\u8fd9\u4e00\u4e8b\u5b9e\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u8fd9\u79cd\u770b\u6cd5\u4e0a\u7684\u504f\u5dee\u5bf9\u5982\u4f55\u786e\u5b9a\u76ee\u6807\u4ea7\u751f\u4e86\u6df1\u8fdc\u7684\u5f71\u54cd\u3002\u4f8b\u5982\uff0c\u5c3d\u7ba1\u5728\u80bf\u7624\u4e2d\u4e0a\u8c03\u7684\u57fa\u56e0\u53ef\u80fd\u5177\u6709\u9776\u6807\u610f\u4e49\uff0c\u4f46\u6211\u4eec\u73b0\u5728\u4e86\u89e3\u5230\uff0c\u8bb8\u591a\u8fd9\u6837\u7684\u57fa\u56e0\u6839\u672c\u6ca1\u6709\u88ab\u764c\u7ec6\u80de\u8868\u8fbe\u3002\u76f8\u53cd\uff0c\u5b83\u4eec\u7531TME\u4e2d\u7684\u7ec6\u80de\u6210\u5206\u8868\u8fbe\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u9519\u7efc\u590d\u6742\u7684\u80bf\u7624\u751f\u6001\u7cfb\u7edf\u662f\u5982\u6b64\u591a\u6837\u5316\uff0c\u4ee5\u81f3\u4e8e\u5f53\u6211\u4eec\u5c06\u5176\u89c6\u4e3a\u4e00\u4e2a\u6574\u4f53\u65f6\uff0c\u6211\u4eec\u4e0d\u4ec5\u635f\u5931\u4e86\u5f02\u8d28\u6027\u7684\u77e5\u8bc6\uff0c\u800c\u4e14\u5931\u53bb\u4e86\u6709\u5173\u7ec6\u80de\u7c7b\u578b\u3001\u7ec6\u80de\u72b6\u6001\u548c\u7ec6\u80de\u95f4\u901a\u8baf\u7684\u91cd\u8981\u4fe1\u606f\u3002\u5c31\u5982\u540c\u514d\u75ab\u7597\u6cd5\u7684\u6210\u529f\u4f8b\u8bc1\uff0c\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u5982\u4f55\u76f8\u4e92\u914d\u5408\u4ee5\u7ef4\u6301\u548c\u91cd\u5851\u5fae\u73af\u5883\uff0c\u6700\u7ec8\u51b3\u5b9a\u4e86\u6cbb\u7597\u53cd\u5e94\u548c\u8010\u836f\u6027\u3002\u5982\u679c\u9776\u5411\u764c\u7ec6\u80de\u4e0d\u80fd\u6cbb\u6108\u764c\u75c7\uff0c\u5219\u9776\u5411TME\u4e2d\u5176\u4ed6\u7ec6\u80de\u7684\u95f4\u63a5\u65b9\u6cd5\u53ef\u80fd\u4f1a\u63d0\u9ad8\u6cbb\u7597\u6548\u679c\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u56e0\u6b64\uff0c\u6211\u4eec\u6bd4\u4ee5\u5f80\u4efb\u4f55\u65f6\u5019\u90fd\u66f4\u9700\u8981\u5173\u6ce8\u5355\u4e2a\u7ec6\u80de\u7684\u89c6\u89d2\u3002\u5982\u679cTME\u662f\u6240\u6709\u6297\u764c\u7597\u6cd5\u7684\u6218\u573a\uff0c\u90a3\u4e48\u5168\u9762\u7814\u7a76\u8be5\u9886\u57df\u662f\u8d62\u5f97\u6218\u6597\u7684\u524d\u63d0\u3002\u5355\u7ec6\u80de\u6d4b\u5e8f\u6280\u672f\u7684\u6700\u65b0\u8fdb\u5c55\u4e3a\u6211\u4eec\u63d0\u4f9b\u4e86\u4e00\u79cd\u6700\u5f3a\u5927\u8f6c\u53d8\u65b9\u6cd5\u5b66\u7684\u624b\u6bb5\uff0c\u4f7f\u6211\u4eec\u80fd\u591f\u4ece\u7ec6\u80de\u6c34\u5e73\u91cd\u65b0\u5ba1\u89c6\u5206\u5b50\u548c\u9057\u4f20\u8fc7\u7a0b\u3002\u4e13\u6ce8\u7814\u7a76\u548c\u9776\u5411TME\u4efb\u4f55\u4e00\u4e2a\u7ec4\u6210\u90e8\u5206\uff0c\u5c06\u4f7f\u6211\u4eec\u80fd\u591f\u4ece\u6839\u672c\u4e0a\u6539\u53d8\u6e38\u620f\u89c4\u5219\uff0c\u65e0\u8bba\u662f\u7528\u4e8e\u764c\u75c7\u7814\u7a76\uff0c\u8fd8\u662f\u6700\u7ec8\u7528\u4e8e\u5176\u4ed6\u6240\u6709\u75be\u75c5\u7684\u7814\u7a76\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u3010\u8bd1\u8005\u7b80\u4ecb\u3011<\/div>\n<div>\u6c6a\u4eae\uff0c\u57fa\u56e0\u6167\u521b\u59cb\u4eba\uff0c\u54c8\u5c14\u6ee8\u533b\u79d1\u5927\u5b66\u751f\u7269\u4fe1\u606f\u4e13\u4e1a\uff0c2009\u5e74\u8d77\u5148\u540e\u670d\u52a1\u4e8e\u56fd\u5bb6\u4eba\u7c7b\u57fa\u56e0\u7ec4\u5357\u65b9\u4e2d\u5fc3\u3001\u534e\u5927\u57fa\u56e0\u548c\u836f\u660e\u5eb7\u5fb7\u7684\u6280\u672f\u3001\u4ea7\u54c1\u548c\u5e02\u573a\u5c97\u4f4d\u3002\u73b0\u517c\u4efb\u56fd\u5bb6\u53d1\u6539\u59d4\u6218\u7565\u6027\u65b0\u5174\u4ea7\u4e1a\u53d1\u5c55\u5c55\u671b\u7f16\u59d4\u3001\u4e2d\u56fd\u9057\u4f20\u5b66\u4f1a\u4ea7\u4e1a\u4fc3\u8fdb\u4f1a\u59d4\u5458\u7b49\u30022015\u5e74\u4e2a\u4eba\u72ec\u81ea\u521b\u7acb\u201c\u57fa\u56e0\u6167\u201d\u54c1\u724c\u5e76\u4e8e2016\u5e74\u5b75\u5316\u6210\u7acb\u57fa\u56e0\u884c\u4e1a\u79d1\u6280\u5a92\u4f53\u548c\u54a8\u8be2\u673a\u6784\uff0c\u670d\u52a1\u57fa\u56e0\u4ea7\u4e1a\u521b\u65b0\u521b\u4e1a\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u53c2\u8003\u8d44\u6599\uff1a<\/div>\n<div>https:\/\/www.nature.com\/articles\/s43018-019-0015-9?from=timeline&amp;isappinstalled=0\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>\u57fa\u56e0\u6167\u51fa\u54c1\u300a2020\u57fa\u56e0\u884c\u4e1a\u62a5\u544a\u300b<\/div>\n<div>\u7eb8\u8d28\u7248\u65e9\u9e1f\u4f18\u60e0\u62a2\u8d2d\u4e2d<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247495800&amp;idx=1&amp;sn=f59e246b4c2dc9859a12b918113c8614&amp;chksm=eb7142cfdc06cbd90caf8521ea25be6c50573fa5d1cb1fd09441042908925adf12d75b3c5c11&amp;scene=21#wechat_redirect\">\uff08\u63d0\u7eb2\uff09<\/a><\/div>\n<div>3\u67081\u65e5\u4e4b\u524d\u00a0 88\u5143\/\u672c<\/div>\n<div>\u00a03\u67081\u65e5\u4e4b\u540e\u00a0 188\u5143\/\u672c<\/div>\n<div>\u957f\u6309\u6d77\u62a5\u8bc6\u522b\u4e8c\u7ef4\u7801\u62a2\u8d2d<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgB0OZkvaVxca1AmukG0F1feIjpsAA3KUNG89EkiaLfwzPOico6gyFkwIx5icUkXviakT8PzjdOAk44oyg.jpeg\" alt=\"RmFicvQBAkgB0OZkvaVxca1AmukG0F1feIjpsAA3KUNG89EkiaLfwzPOico6gyFkwIx5icUkXviakT8PzjdOAk44oyg\"\/><\/figure><\/div>\n\n<\/div>\n<div><\/div>\n\n<div>\u611f\u8c22\u652f\u6301\u4f19\u4f34\uff0c\u4f7f\u5f97\u62a5\u544a\u5e73\u4ef7\u53d1\u5e03<\/div>\n\n<div>\u00a0 \u8054\u5408\u63a8\u51fa\u00a0\u00a0 \u00a0\u00a0<\/div>\n<div>\u8bfa\u552f\u8d5e\u00a0\u00a0\u6850\u6811\u751f\u7269 \u00a0<\/div>\n<div>\u00a0\u6218\u7565\u5408\u4f5c\u00a0\u00a0 \u00a0\u00a0<\/div>\n<div>\u7eb3\u6602\u8fbe\u00a0 \u534e\u5927\u667a\u9020\u00a0 \u7fca\u5723\u751f\u7269\u00a0\u00a0<\/div>\n<div>\u5409\u56e0\u52a0\u00a0 \u81fb\u548c\u79d1\u6280\u00a0 \u5965\u7f8e\u6cf0\u514b\u00a0 \u767e\u4e16\u8bfa<\/div>\n<div>\u00a0\u9e23\u8c22\u5355\u4f4d\u00a0\u00a0 \u00a0\u00a0<\/div>\n<div>\u4f18\u8fc5\u533b\u5b66\u00a0 \u771f\u56fa\u751f\u7269\u00a0 \u679c\u58f3\u751f\u7269<\/div>\n\n<div style=\"text-align: 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