{"id":9139,"date":"2020-03-06T12:01:09","date_gmt":"2020-03-06T04:01:09","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&mid=100012822&idx=1&sn=1b8a71dc17239f10d6c7044f439126e7&chksm=6b7141a15c06c8b777fcb6ad858fb6546a77f9e943b12279f378b245a0fc903e0d83ba22c411#rd"},"modified":"2026-04-08T09:58:56","modified_gmt":"2026-04-08T01:58:56","slug":"50102101","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2020\/03\/06\/50102101\/","title":{"rendered":"\u6700\u65b0\u53d1\u73b0 | \u7a7a\u6c14\u6216\u53ef\u4f20\u64ad\u75c5\u6bd2\u7684\u539f\u56e0\u539f\u6765\u662f\u8fd9\u4e2a\uff0c\u6218\u75ab\u73af\u5883\u76d1\u6d4b\u5f88\u5fc5\u8981"},"content":{"rendered":"
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\"RmFicvQBAkgBAcHUjEqv4sVpic8dYzbGOEd2Q13GF8rfIj5FxqoAndw4qVSDJXpbMAk7GAZPHvwEK0nYhFSEbibdw\"\/<\/figure><\/div>\n\n
3\u67083\u65e5\uff0c\u6700\u65b0\u516c\u5e03\u7684\u7b2c\u4e03\u7248\u300a\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u80ba\u708e\u8bca\u7597\u65b9\u6848\u300b\u663e\u793a\uff0c\u5728\u76f8\u5bf9\u5c01\u95ed\u7684\u73af\u5883\u4e2d\u957f\u65f6\u95f4\u66b4\u9732\u4e8e\u9ad8\u6d53\u5ea6\u6c14\u6eb6\u80f6\u60c5\u51b5\u4e0b\u4e2d\u5b58\u5728\u7ecf\u6c14\u6eb6\u80f6\u4f20\u64ad\u7684\u53ef\u80fd\u3002\u75c5\u6bd2\u662f\u5426\u53ef\u4ee5\u901a\u8fc7\u6c14\u6eb6\u80f6\u4f20\u64ad\uff1f\u662f\u5982\u4f55\u8fdb\u884c\u4f20\u64ad\u7684\u5462\uff1f\u6700\u65b0\u7684\u4e00\u9879\u7814\u7a76\u53ef\u80fd\u89e3\u5f00\u5176\u4e2d\u90e8\u5206\u8c1c\u56e2\u3002<\/div>\n
\u6587\u7ae0\/\u57fa\u56e0\u6167\uff08\u516c\u4f17\u53f7\uff1aGeneClub-1)<\/div>\n
\u4f9b\u7a3f\/\u6587\u7ae0\u4e00\u4f5c\u7f16\u8f91\/Whiteney<\/div>\n
\u5173\u952e\u8bcd\/\u7a7a\u6c14\u9897\u7c92\u7269\u65b0\u51a0\u80ba\u708e\u00a0<\/div>\n
\u5c01\u9762\u56fe\/NVIC<\/div>\n
\u00a0<\/div>\n
\u75ab\u60c5\u671f\u95f4\u7a7a\u6c14\u4e2d\u68c0\u6d4b\u5230\u65b0\u51a0\u75c5\u6bd2<\/div>\n
\u56fd\u5bb6\u536b\u5065\u59d4\u300a\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u80ba\u708e\u8bca\u7597\u65b9\u6848\uff08\u8bd5\u884c\u7b2c\u4e03\u7248\uff09\u300b\u4e2d\u63d0\u5230\uff0c\u5728\u76f8\u5bf9\u5c01\u95ed\u7684\u73af\u5883\u4e2d\u957f\u65f6\u95f4\u66b4\u9732\u4e8e\u9ad8\u6d53\u5ea6\u6c14\u6eb6\u80f6\u60c5\u51b5\u4e0b\u4e2d\u5b58\u5728\u7ecf\u6c14\u6eb6\u80f6\u4f20\u64ad\u7684\u53ef\u80fd\u3002\u75c5\u6bd2\u662f\u5426\u53ef\u4ee5\u901a\u8fc7\u6c14\u6eb6\u80f6\u4f20\u64ad\uff1f<\/div>\n
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\n
\"RmFicvQBAkgBAcHUjEqv4sVpic8dYzbGOE1ibRWXLtibiaQt0j5qlTxm8sbmbD7KJWmmL1DNYOXOibagwWqUlowCheXg\"\/<\/figure><\/div>\n\n
\u25b3\u56fe1\uff1a\u00a0\u6765\u6e90\/\u6587\u7ae0\u4e00\u4f5c\u7814\u7a76\u56e2\u961f\uff0c\u4e0b\u540c<\/div>\n
\u5fae\u751f\u7269\u7ec4\u79d1\u5b66\u5bb6\u8fdb\u4e00\u6b65\u7814\u7a76\u53d1\u73b0\uff0c\u7a7a\u6c14\u9897\u7c92\u5fae\u751f\u7269\u6765\u6e90\u5f88\u591a\uff0c\u5176\u590d\u6742\u7684\u7269\u79cd\u8fdb\u5316\u5173\u7cfb\u548c\u529f\u80fd\u591a\u6837\u6027\u53ef\u4e0e\u571f\u58e4\u548c\u6c34\u73af\u5883\u76f8\u63d0\u5e76\u8bba\uff0c\u5171\u53d1\u73b0\u4e86702\u79cd\u7ec6\u83cc\u300127\u79cd\u771f\u6838\u751f\u7269\u300156\u79cd\u75c5\u6bd2\u548c14\u79cd\u53e4\u7ec6\u83cc\u3002\u5176\u4e2d\u75c5\u6bd2\u7ea6\u53603%\uff1b<\/div>\n
\u7a7a\u6c14\u4f20\u64ad\u4e2d\u7684\u5fae\u751f\u7269\uff0c\u591a\u4ee5\u75e4\u75ae\u4e19\u9178\u6746\u83cc\u3001\u5927\u80a0\u6746\u83cc\u3001\u9c81\u5f0f\u4e0d\u52a8\u6746\u83cc\u3001\u55dc\u6dc0\u7c89\u4e73\u6746\u83cc\u548c\u7f57\u4f0a\u6c0f\u4e73\u6746\u83cc\u4ee5\u53ca\u51e0\u79cd\u75c5\u6bd2\u5360\u4e3b\u5bfc\u3002<\/div>\n
\u6700\u65b0\u7814\u7a76\uff1a\u7a7a\u6c14\u9897\u7c92\u7269\u5bb9\u7eb3\u4e0e\u5065\u5eb7\u76f8\u5173\u7684\u5fae\u751f\u7269<\/div>\n\n
\n
\"RmFicvQBAkgBAcHUjEqv4sVpic8dYzbGOE4O38HenKsatrEZV57x5CezOM8z1yfwa3cJCffVLDZianCqjEyiaic7CUA\"\/<\/figure><\/div>\n\n
\u25b3 \u56fe2\uff1a\u6765\u6e90\/Genome biology<\/div>\n
\u8fd1\u65e5\uff0c\u540c\u6d4e\u5927\u5b66\u9644\u5c5e\u7b2c\u5341\u4eba\u6c11\u533b\u9662\u79e6\u6960\u7814\u7a76\u5458\u4e0e\u6e05\u534e\u5927\u5b66\u6731\u542c\u6559\u6388\u3001\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821Jack Gilbert\u6559\u6388\u8054\u5408\u7814\u7a76\uff0c\u5728Genome biology\u4e0a\u53d1\u8868\u4e86\u6700\u65b0\u7684\u7814\u7a76\u6210\u679cLongitudinal survey of microbiome associated with particulate matter in a megacity\u3002<\/div>\n
\u00a0<\/div>\n
\u901a\u8fc7\u5bf92012\u5e7410\u6708\u548c2013\u5e743\u6708\u76846\u4e2a\u6708\u671f\u95f4\uff0c\u5317\u4eac\u7a7a\u6c14\u4e2dPM2.5\u548cPM10\u7684106\u4e2a\u6837\u54c1\uff08\u8986\u76d6\u5317\u4eac\u51e0\u6b21\u4e25\u91cd\u7684\u96fe\u973e\u4e8b\u4ef6\uff09\u8fdb\u884c\u4e86\u7eb5\u5411\u5b8f\u57fa\u56e0\u7ec4\u8c03\u67e5\uff0c\u63ed\u793a\u4e86\u7a7a\u6c14\u9897\u7c92\u7269\u53ef\u5bb9\u7eb3\u4e30\u5bcc\u4e14\u52a8\u6001\u7684\u5fae\u751f\u7269\uff0c\u5305\u62ec\u4e0e\u6f5c\u5728\u5065\u5eb7\u95ee\u9898\u76f8\u5173\u7684\u4e00\u7cfb\u5217\u5fae\u751f\u7269\uff0c\u6216\u53ef\u4f20\u64ad\u4eba\u7c7b\u81f4\u75c5\u83cc\u3002<\/div>\n
\u00a0<\/div>\n
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PM2.5\u548cPM10\u662f\u7a7a\u6c14\u4e2d\u4eba\u4f53\u53ef\u5438\u5165\u3001\u76f4\u5f84\u5206\u522b\u662f\u22642.5 \u03bcm\u548c\u226410 \u03bcm\u7684\u9897\u7c92\u7269\uff0c\u5176\u4e2dPM10\u53ef\u8fdb\u5165\u4e0a\u547c\u5438\u9053\uff0c\u800cPM2.5\u7531\u4e8e\u9897\u7c92\u66f4\u4e3a\u7ec6\u5c0f\u3001\u53ef\u5165\u80ba\u3002<\/div>\n
\u00a0<\/div>\n
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\u00a0<\/div>\n
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\u5c06\u5fae\u751f\u7269\u7ec4\u6210\u7684\u5dee\u5f02\u6821\u6b63\u8ddd\u79bb\uff08Bray-Curtis\u8ddd\u79bb\uff09\u4e0e\u4e3b\u8981\u7684\u6c14\u8c61\u5b66\u56e0\u7d20\u76f8\u5173\u8054\uff0c\u53d1\u73b0\u6c14\u6e29\u548c\u9732\u70b9\u6e29\u5ea6\u4e0ePM\u6837\u54c1\u4e2d\u7269\u79cd\u7ec4\u6210\u76f8\u5173\u6027\u6700\u5f3a\uff08\u56fe3b\uff09\u3002\u7814\u7a76\u8005\u8fd8\u53d1\u73b0\u5728PM2.5\u9897\u7c92\u548cPM10\u9897\u7c92\u6837\u54c1\u4e2d\u5b58\u5728\u4eba\u7c7b\u75c5\u539f\u4f53DNA\u7247\u6bb5\uff0c\u8fd9\u4e9b\u6709\u5bb3\u5fae\u751f\u7269\u7684\u5e8f\u5217\u6570\u4ec5\u4e0ePM\u6d53\u5ea6\u5448\u5f31\u76f8\u5173\u6027\uff08\u56fe3c\uff09\uff1b\u4e00\u4e9b\u75c5\u539f\u4f53\u7684\u76f8\u5bf9\u4e30\u5ea6\u57281\u6708\u4efd\u51fa\u73b0\u4e86\u663e\u8457\u7684\u9ad8\u5cf0\uff0c\u8fd9\u4e5f\u4e0e\u7814\u7a76\u671f\u95f4\u6700\u4e25\u91cd\u7684\u96fe\u973e\u4e8b\u4ef6\u76f8\u543b\u5408\u3002<\/div>\n\n
\n
\"RmFicvQBAkgBAcHUjEqv4sVpic8dYzbGOEWkcGs2AibWgujTic7DUYBiaUDXGvTuGfjSLyPu53aEkfmiafdvxH0q7O0A\"\/<\/figure><\/div>\n\n
\u25b3\u56fe3\uff1a\u00a0\u7a7a\u6c14\u9897\u7c92\u7269\u76f8\u5bf9\u4e30\u5ea6\u8f83\u9ad8\u7684\u5fae\u751f\u7269\u79cd\u7c7b\u53ca\u5176\u4e0e\u6c14\u8c61\u5b66\u56e0\u7d20\u7684\u76f8\u5173\u6027\u5206\u6790<\/div>\n
\u5176\u4e2d\u7684\u75c5\u539f\u4f53\u5305\u62ec\u8bb8\u591a\u4eba\u7c7b\u5171\u751f\u83cc\u3001\u6f5c\u5728\u7684\u4eba\u7c7b\u75c5\u539f\u4f53\uff0c\u5982Pseudomonas aeruginosa\uff08\u94dc\u7eff\u5047\u5355\u80de\u83cc\uff09\u3001Stenotrophomonas maltophilia\uff08\u55dc\u9ea6\u82bd\u7a84\u98df\u5355\u80de\u83cc\uff09\u3001Talaromyces marneffei\uff08\u9a6c\u5c14\u5c3c\u83f2\u7bee\u72b6\u83cc\uff09\uff0c\u4ee5\u53ca\u6f5c\u5728\u7684\u9e21\u76f8\u5173\u75c5\u539f\u4f53\uff0c\u5982Gallid herpesvirus\uff08\u79bd\u75b1\u75b9\u75c5\u6bd2\uff09\u3001avian endogenous retrovirus\uff08\u79bd\u5185\u6e90\u6027\u9006\u8f6c\u5f55\u75c5\u6bd2\uff0cAEV\uff09\u3002<\/div>\n
\u00a0<\/div>\n
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\u00a0<\/div>\n
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\u7814\u7a76\u8005\u9274\u5b9a\u4e86\u53ef\u80fd\u5bf935\u79cd\u6297\u751f\u7d20\u4ea7\u751f\u8010\u836f\u6027\u7684\u57fa\u56e0\u3002\u7ed3\u679c\u53d1\u73b0\uff0c\u5728\u6574\u4e2a\u7814\u7a76\u671f\u95f4\uff0c\u7f16\u7801\u6297\u751f\u7d20\u6297\u6027\u57fa\u56e0\u7684\u6bd4\u4f8b\u4fdd\u6301\u7a33\u5b9a\uff0c\u4e14\u6297\u751f\u7d20\u6297\u6027\u57fa\u56e0\uff08ARGs\uff09\u7684RPKM\u503c\uff08\u6bcf\u767e\u4e07reads\u4e2d\u6765\u81ea\u4e8eARGs\u57fa\u56e0\u6bcf\u5343\u78b1\u57fa\u957f\u5ea6\u7684reads\u6570\uff0c\u7528\u4e8e\u63cf\u8ff0ARG\u57fa\u56e0\u7684\u8f6c\u5f55\u6c34\u5e73\uff09\u5728PM2.5\u9897\u7c92\u548cPM10\u9897\u7c92\u95f4\u6ca1\u6709\u663e\u8457\u5dee\u5f02\uff08\u56fe4a\uff0cb\uff09\uff0c\u8fd9\u8868\u660e\u5728\u8fd9\u79cd\u73af\u5883\u4e0b\u666e\u904d\u7684\u9009\u62e9\u538b\u529b\u3002<\/div>\n\n
\n
\"RmFicvQBAkgBAcHUjEqv4sVpic8dYzbGOESWwuGlPbM5EGH0bjWib3wvib9BP4pibWHiaJROcdDOMmY9gy6sicW2bZpCw\"\/<\/figure><\/div>\n\n
\u25b3\u56fe4\uff1a\u00a0\u4e24\u79cd\u7c7b\u578bPM\u53ca\u4e0e\u4eba\u80a0\u9053\u3001\u6d77\u6d0b\u5fae\u751f\u7269\u542b\u6709\u7684\u6297\u751f\u7d20\u6297\u6027\u57fa\u56e0\u548c\u89e3\u6bd2\u57fa\u56e0\u6bd4\u8f83\u5206\u6790<\/div>\n
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\u00a0<\/div>\n
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\u00a0<\/div>\n
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\u5bf9\u7a7a\u6c14\u5fae\u9897\u7c92\u4e2d\u5fae\u751f\u7269\u52a8\u6001\u76d1\u6d4b\uff0c\u53ef\u8bc4\u4f30\u7a7a\u6c14\u4e2d\u5b58\u5728\u75c5\u539f\u5fae\u751f\u7269\uff0c\u53ca\u7531\u6b64\u4ea7\u751f\u7684\u611f\u67d3\u98ce\u9669\uff0c\u7ed3\u5408\u5f53\u5730\u6d41\u884c\u75c5\u5b66\uff0c\u53ef\u4e3a\u672a\u6765\u5236\u5b9a\u516c\u5171\u536b\u751f\u5b89\u5168\u4e8b\u4ef6\uff08\u5982\u65b0\u51a0\u80ba\u708e\u75ab\u60c5\uff09\u7684\u9632\u75ab\u7b56\u7565\u3001\u964d\u4f4e\u66b4\u9732\u98ce\u9669\u63d0\u4f9b\u79d1\u5b66\u7406\u8bba\u4f9d\u636e\u3002<\/div>\n
\u65e0\u72ec\u6709\u5076\uff0c3\u67084\u65e5\u65b0\u52a0\u5761\u56fd\u5bb6\u4f20\u67d3\u75c5\u4e2d\u5fc3Sean Wei Xiang Ong\u7b49\u4eba\u5728JAMA \u5728\u7ebf\u53d1\u8868\u7814\u7a76\u6210\u679c\uff0c\u901a\u8fc7\u673a\u8f7d\u611f\u67d3\u9694\u79bb\u5ba4\u51853\u540dCOVID-19\u786e\u8bca\u60a3\u8005\u623f\u5185\u6837\u672c\u7684\u68c0\u6d4b\u7ed3\u679c\uff0c\u53d1\u73b0\u4e00\u540d\u8f7b\u5ea6\u4e0a\u547c\u5438\u9053\u53d7\u7d2f\u7684SARS-CoV-2\u60a3\u8005\u5bf9\u73af\u5883\u9020\u6210\u4e86\u5e7f\u6cdb\u7684\u6c61\u67d3\uff1a\u9a6c\u6876\u548c\u6c34\u69fd\u6837\u672c\u5747\u4e3a\u9633\u6027\u3002<\/div>\n
SARS-CoV-2\u60a3\u8005\u901a\u8fc7\u547c\u5438\u9053\u98de\u6cab\u548c\u7caa\u4fbf\u6392\u51fa\u800c\u5bf9\u73af\u5883\u9020\u6210\u4e25\u91cd\u6c61\u67d3\uff0c\u8868\u660e\u73af\u5883\u662f\u6f5c\u5728\u7684\u4f20\u64ad\u5a92\u4ecb\uff0c\u8fdb\u4e00\u6b65\u652f\u6301\u73af\u5883\u76d1\u6d4b\u5c24\u5176\u662f\u7a7a\u6c14\u5fae\u9897\u7c92\u4e2d\u5fae\u751f\u7269\u52a8\u6001\u76d1\u6d4b\u7684\u5fc5\u8981\u6027\u3002<\/div>\n
\u00a0<\/div>\n
\u53c2\u8003\u8d44\u6599\uff1a<\/div>\n
1\uff09Nan Qin , Peng Liang , Chunyan Wu et al., Longitudinal survey of microbiome associated with particulate matter in a megacity, Genome Biology (2020) 21:55<\/div>\n
2) Yanfang Jiang, Haifeng Wang, Shucheng Hua et al.,Clinical Data on Hospital Environmental Hygiene Monitoring and Medical Staffs Protection during the Coronavirus Disease 2019 Outbreak, doi: https:\/\/doi.org\/10.1101\/2020.02.25.20028043, Feb. 28,2020<\/div>\n
3)\u00a0Sean Wei Xiang Ong,, Yian Kim Tan, Po Ying Chia et al. Air, Surface Environmental, and Personal Protective Equipment Contamination by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) From a Symptomatic Patient, JAMA(2020)<\/div>\n
\u00a0<\/div>\n
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\u00a0<\/div>\n
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\u00a0<\/div>\n
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\n
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\u00a0<\/div>\n
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\u00a0<\/div>\n
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