{"id":9100,"date":"2020-05-25T03:04:31","date_gmt":"2020-05-24T19:04:31","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&mid=100013488&idx=1&sn=594a91b081a8f05cbc4890e43a924455&chksm=6b7147075c06ce111c919431ce929b0704d630ac9e27cd21444a223a18bf024eb7ad2d725e4c#rd"},"modified":"2026-04-02T09:56:53","modified_gmt":"2026-04-02T01:56:53","slug":"549851","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2020\/05\/25\/549851\/","title":{"rendered":"\u57fa\u56e0\u5468\u62a5\uff1a\u603b\u7406\u9f13\u52b1\u7814\u53d1\u65e0\u9700\u5b9e\u9a8c\u5ba4\u73af\u5883\u7684\u6838\u9178\u68c0\u6d4b\uff0c\u6211\u56fd\u65b0\u51a0\u75ab\u82d7I\u671f\u8bd5\u9a8c\u4e50\u89c2"},"content":{"rendered":"
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\"0?wx_fmt=jpeg\"\/<\/figure><\/div>\n\n
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\u66f4\u591a\u8be6\u60c5\u89c1\u57fa\u56e0\u6167GeneMail\uff08\u6295\u7a3f\u00a0info@genonet.cn\uff09<\/div>\n
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\u5f53\u5730\u65f6\u95f45\u670822\u65e5\u665a\u95f4\uff0c\u4e2d\u56fd\u519b\u4e8b\u79d1\u5b66\u9662\u519b\u4e8b\u533b\u5b66\u7814\u7a76\u9662\u751f\u7269\u5de5\u7a0b\u7814\u7a76\u6240\u9648\u8587\u9662\u58eb\u5728The Lancet\u520a\u53d1\u7814\u7a76\u6210\u679c\uff0c\u62a5\u544a\u4e86\u5728\u4e2d\u56fd\u5065\u5eb7\u6210\u5e74\u4eba\u4e2d\u4f7f\u7528\u7684Ad5\u8f7d\u4f53COVID-19\u75ab\u82d7\u5728\u63a5\u79cd\u540e28\u5929\u5185\u76841\u671f\u4e34\u5e8a\u6570\u636e\uff0c\u4e00\u671f\u4e34\u5e8a108\u4f4d\u5fd7\u613f\u8005\u5747\u4ea7\u751f\u6297\u4f53\u548c\u663e\u8457\u7ec6\u80de\u514d\u75ab\u5e94\u7b54\u3002<\/div>\n
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\u53c2\u8003\u6587\u732e>><\/div>\n
Feng-Cai Zhu et al., Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial, THE LANCET(2020)<\/div>\n
\u00a0<\/div>\n
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\u539f\u6587\u94fe\u63a5>><\/div>\n
http:\/\/www.gov.cn\/xinwen\/2020-05\/24\/content_5514393.htm<\/div>\n
\u00a0<\/div>\n
\u25a0 FDA\u6279\u51c6\u524d\u5217\u817a\u764c\u9776\u5411\u836f\u548c\u4f34\u968f\u8bca\u65ad<\/div>\n
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\u540c\u65f6\uff0cFDA\u8fd8\u6279\u51c6\u4e86\u4e24\u79cd\u53ef\u7528\u4e8e\u786e\u5b9a\u5bf9\u8be5\u836f\u6700\u4f73\u53cd\u5e94\u8005\u7684\u4f34\u968f\u8bca\u65ad\u65b9\u6cd5\uff1a<\/div>\n
1\uff09Myriad Genetics\u7684BRACAnalysis CDx\u7528\u6765\u8bc6\u522b\u5177\u6709\u79cd\u7cfbBRCA1 \/ 2\u7a81\u53d8\u7684\u60a3\u8005<\/div>\n
2\uff09Foundation Medicine\u7684FoundationOne CDx\u7528\u6765\u8bc6\u522b\u5177\u6709HRR\u7a81\u53d8\u57fa\u56e0\u7684\u60a3\u8005\u3002<\/div>\n
\u00a0<\/div>\n
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\u2014\u2014\u4e0e\u65b0\u51a0\u76f8\u4e92\u4f5c\u7528\u7684\u86cb\u767d\u8d28<\/div>\n
\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\u7684Nevan Krogan\u56e2\u961f\u5728Nature\u671f\u520a\u6700\u8fd1\u53d1\u6587\uff0c\u4ecb\u7ecd\u4e8669\u79cd\u53ef\u836f\u7269\u5316\u7684\u3001\u53c2\u4e0e\u514d\u75ab\u8c03\u8282\u4ee5\u5916\u8fc7\u7a0b\u7684\u4eba\u7c7b\u86cb\u767d\u8d28\u3002<\/div>\n
\u503c\u5f97\u5173\u6ce8\u7684\u662f\uff0c\u8fd9\u91cc\u5c06\u836f\u7269\u9776\u6807\u8303\u56f4\u4ece\u75c5\u6bd2\u590d\u5236\u673a\u5236\u6269\u5c55\u5230\u4f53\u5185\u4e0eSARS-CoV-2\u76f8\u4e92\u4f5c\u7528\u7684\u86cb\u767d\u8d28\uff0c\u5176\u4e2d\uff0c\u81f3\u5c11\u670913\u79cd\u5019\u9009\u836f\u7269\u5df2\u7ecf\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff08\u5982\u4e0b\u8868\uff09\uff1a<\/div>\n\n
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\"RmFicvQBAkgBaialRnp913aoLpyaoCFV70waOyDWo1Ya9GZzV8efiaraAeNGOmM6jtkI2Hv5St4gFnZO8qQHOQq6Q\"\/<\/figure><\/div>\n\n
\u4e4b\u524d\u7684\u836f\u7269\u5982remdesivir\u76f4\u63a5\u6291\u5236\u75c5\u6bd2\u7684RNA\u805a\u5408\u9176\uff0c\u8bd5\u9a8c\u6570\u636e\u8868\u660e\uff0c\u5b83\u53ef\u4ee5\u7f29\u77ed\u611f\u67d3\u65f6\u95f4\uff0c\u4f46\u4e0d\u80fd\u663e\u8457\u63d0\u9ad8\u5b58\u6d3b\u7387\u3002\u76ee\u524d\u79d1\u5b66\u5bb6\u4e5f\u7814\u7a76\u5728\u75be\u75c5\u53d1\u5c55\u540e\u671f\u6291\u5236\u75c5\u6bd2\u611f\u67d3\u5e76\u7f13\u89e3\u5371\u53ca\u751f\u547d\u75c7\u72b6\u7684\u836f\u7269\u3002<\/div>\n
\u66f4\u591a\u8be6\u60c5>><\/div>\n
https:\/\/www.nature.com\/articles\/d41587-020-00013-z<\/div>\n
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\u66f4\u591a\u8be6\u60c5>><\/div>\n
\u7814\u5236\u65b0\u51a0\u80ba\u708e\u5f3a\u6548\u836f\uff01\u5317\u5927\u8c22\u6653\u4eae\u56e2\u961f\u4e0e\u5408\u4f5c\u8005\u516c\u5e03\u6700\u65b0\u91cd\u8981\u8fdb\u5c55<\/a><\/div>\n
\u53c2\u8003\u6587\u732e>><\/div>\n
Yunlong Cao et al.,\u00a0Potent neutralizing antibodies against SARS-CoV-2 identified by high-throughput single-cell sequencing of convalescent patients\u2019 B cells, Cell(2020)<\/div>\n
\u00a0<\/div>\n
\u25a0\u00a0\u5f20\u6cfd\u6c11\u6559\u6388\u56e2\u961f\u518d\u53d1Cell<\/div>\n
\u901a\u8fc7scRNA-seq\u523b\u753b\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u80bf\u7624\u5fae\u73af\u5883<\/div>\n
4\u670816\u65e5\uff0c\u767e\u5965\u667a\u6c47\u521b\u59cb\u4eba\u3001\u5317\u5927\u5f20\u6cfd\u6c11\u6559\u6388\u56e2\u961f\u4e0e\u5408\u4f5c\u8005\u5728Cell\u4e0a\u53d1\u8868\u7814\u7a76\u6210\u679c\uff0c\u5229\u7528\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\u6280\u672f\u5bf9\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u80bf\u7624\u5fae\u73af\u5883\uff0c\u7279\u522b\u662f\u6d78\u6da6\u9ad3\u7cfb\u7ec6\u80de\u7c7b\u7fa4\u9996\u6b21\u8fdb\u884c\u4e86\u7cfb\u7edf\u6027\u7684\u523b\u753b\uff0c\u540c\u65f6\u5229\u7528\u5c0f\u9f20\u6a21\u578b\uff0c\u5bf9anti-CSF1R\u6291\u5236\u5242\u548canti-CD40\u6fc0\u52a8\u5242\u4e24\u79cd\u9776\u5411\u9ad3\u7cfb\u7ec6\u80de\u7684\u514d\u75ab\u6cbb\u7597\u7b56\u7565\u6f5c\u5728\u7684\u4f5c\u7528\u673a\u7406\u7ed9\u51fa\u4e86\u89e3\u91ca\u3002\u00a0(\u53c2\u8003\u201c\u767e\u5965\u667a\u6c47+\u201d\uff09<\/div>\n
\u53c2\u8003\u6587\u732e>><\/div>\n
Lei Z. et al., Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer. Cell. 2020.<\/div>\n
\u00a0<\/div>\n
\u25a0\u00a0\u5355\u7ec6\u80de\u6d4b\u5e8fSMART-seq3\u95ee\u4e16<\/div>\n
\u6bcf\u4e2a\u7ec6\u80de\u68c0\u6d4b\u6570\u5343\u4e2a\u8f6c\u5f55\u672c<\/div>\n
\u5f53\u524d\u7684\u5355\u7ec6\u80de\u77ed\u8bfb\u957fRNA\u6d4b\u5e8f\u65b9\u6cd5\u5bf9RNA\u8ba1\u6570\u7684\u80fd\u529b\u6709\u9650\uff0c\u800c\u957f\u8bfb\u6d4b\u5e8f\u6280\u672f\u7f3a\u4e4f\u8de8\u7ec6\u80de\u5927\u89c4\u6a21\u5e94\u7528\u6240\u9700\u7684\u6df1\u5ea6\u30025\u67084\u65e5\uff0c\u745e\u5178\u65af\u5fb7\u54e5\u5c14\u6469\u5361\u7f57\u6797\u65af\u5361\u7814\u7a76\u6240\u8054\u5408\u591a\u5bb6\u56e2\u961f\uff0c\u8054\u5408\u53d1\u5e03\u5355\u7ec6\u80de\u6d4b\u5e8f\u65b9\u6cd5SMART-seq3\uff0c\u7ed3\u5408\u4e86\u5168\u957f\u8f6c\u5f55\u7ec4\u8986\u76d6\u7387\u548c5’\u72ec\u7279\u7684\u5206\u5b50\u8bc6\u522b\u5242RNA\u8ba1\u6570\u7b56\u7565\uff0c\u53ef\u4ee5\u5bf9\u6bcf\u4e2a\u7ec6\u80de\u6570\u5343\u4e2aRNA\u5206\u5b50\u8fdb\u884c\u91cd\u65b0\u5efa\u6a21\uff0c\u5b9e\u73b0\u5728\u5355\u4e2a\u7ec6\u80de\u3001\u5355\u4e2aallele\u3001\u5355\u4e2aisoform\u6c34\u5e73\u4e0a\u7684\u8ba1\u6570\u3002<\/div>\n
\u53c2\u8003\u6587\u732e>><\/div>\n
Michael Hagemann-Jensen et al. Single-cell RNA counting at allele and isoform resolution using Smart-seq3, Nature Biotechnology (2020)<\/div>\n
\u00a0<\/div>\n
\u25bc\u00a0\u00a02020\u300a\u5355\u7ec6\u80de\u884c\u4e1a\u62a5\u544a\u300b<\/div>\n
\u6218\u7565\u5408\u4f5c\u4ec5\u4f591\u540d<\/div>\n\n
\n
\"RmFicvQBAkgBaialRnp913aoLpyaoCFV70ibyhY8I87ujVRwOPk77LFJcNiat0KxtjgkHa98uxkOCfUiamKz05ia1icVw\"\/<\/figure><\/div>\n\n
\u25a0\u00a0\u6768\u8f89\u7b49\u5f00\u53d1\u51fa\u9ad8\u7cbe\u5ea6\u5355\u78b1\u57fa\u7f16\u8f91\u5de5\u5177<\/div>\n
\u663e\u8457\u964d\u4f4eDNA\u8131\u9776<\/div>\n
5\u670818\u65e5\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u8111\u79d1\u5b66\u4e0e\u667a\u80fd\u6280\u672f\u5353\u8d8a\u521b\u65b0\u4e2d\u5fc3\u6768\u8f89\u7814\u7a76\u7ec4\u3001\u4e2d\u79d1\u9662\u8ba1\u7b97\u751f\u7269\u5b66\u7814\u7a76\u6240\u674e\u4ea6\u5b66\u7814\u7a76\u7ec4\u3001\u4ee5\u53ca\u4e2d\u56fd\u519c\u4e1a\u79d1\u5b66\u9662\u6df1\u5733\u519c\u4e1a\u57fa\u56e0\u7ec4\u7814\u7a76\u6240\u5de6\u4e8c\u4f1f\u7814\u7a76\u7ec4\u7b49\u5408\u4f5c\u5728Nature Methods\u6742\u5fd7\u4e0a\u5728\u7ebf\u53d1\u8868\u7814\u7a76\u6210\u679c\u3002<\/div>\n
\u8be5\u7814\u7a76\u6839\u636e\u86cb\u767d\u7ed3\u6784\u9884\u6d4b\u4e86\u8131\u6c28\u9176ssDNA\u7ed3\u5408\u7684\u91cd\u8981\u6c28\u57fa\u9178\uff0c\u5728\u4e0d\u5f71\u54cd\u50ac\u5316\u6d3b\u6027\u7684\u60c5\u51b5\u4e0b\uff0c\u4f7f\u76f8\u5e94\u7684\u6c28\u57fa\u9178\u7a81\u53d8\uff0c\u5b9e\u73b0\u663e\u8457\u964d\u4f4eDNA\u8131\u9776\u7684\u65b0\u578b\u5355\u78b1\u57fa\u7f16\u8f91\u5668\uff08CBE\uff09\u3002\uff08\u53c2\u8003\u201dBioArt\u201c\uff09<\/div>\n
\u53c2\u8003\u6587\u7ae0>><\/div>\n
\u6768\u8f89\/\u674e\u4ea6\u5b66\/\u5de6\u4e8c\u4f1f\u5408\u4f5c\u5f00\u53d1\u9ad8\u7cbe\u5ea6\u3001\u9ad8\u6d3b\u6027\u7684\u5355\u78b1\u57fa\u7f16\u8f91\u5de5\u5177YE1-BE3-FNLS<\/a><\/div>\n
\u53c2\u8003\u6587\u732e>><\/div>\n
Erwei Zuo et al. A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects, Nature Methods (2020)<\/div>\n
\u00a0<\/div>\n
\u25a0 \u9996\u4e2a\u4eba\u7c7b\u9aa8\u9abc\u53d1\u80b2\u8def\u7ebf\u56fe\u548c\u57fa\u56e0\u7f51\u7edc\u88ab\u7ed8\u5236<\/div>\n
\u8fd1\u65e5\uff0c\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\uff08UCLA\uff09\u7684\u518d\u751f\u533b\u5b66\u548c\u5e72\u7ec6\u80de\u7814\u7a76\u4e2d\u5fc3\u7684\u8de8\u5b66\u79d1\u7814\u7a76\u56e2\u961f\u7ed8\u5236\u51fa\u4e86\u4eba\u7c7b\u9aa8\u9abc\u808c\u5982\u4f55\u53d1\u80b2\uff08\u5305\u62ec\u808c\u8089\u5e72\u7ec6\u80de\u5f62\u6210\uff09\u7684\u9996\u4e2a\u8def\u7ebf\u56fe\u3002\u8be5\u7814\u7a76\u53d1\u8868\u5728\u540c\u884c\u8bc4\u5ba1\u6742\u5fd7Cell Stem Cell\u4e0a\uff0c\u786e\u5b9a\u4e86\u9aa8\u9abc\u808c\u7ec4\u7ec7\u4e2d\u4ece\u65e9\u671f\u80da\u80ce\u53d1\u80b2\u4e00\u76f4\u5230\u6210\u5e74\u5b58\u5728\u7684\u5404\u79cd\u7ec6\u80de\u7c7b\u578b\u3002<\/div>\n
\u8be5\u8bba\u6587\u7684\u4f5c\u8005April Pyle\u8c08\u9053\uff1a\u201c\u7531\u4e8e\u8870\u8001\u6216\u75be\u75c5\u5f15\u8d77\u7684\u808c\u8089\u4e22\u5931\u901a\u5e38\u662f\u808c\u8089\u5e72\u7ec6\u80de\u529f\u80fd\u5931\u8c03\u7684\u7ed3\u679c\uff0c\u800c\u8fd9\u5f20\u56fe\u786e\u5b9a\u4e86\u6574\u4e2a\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u808c\u8089\u7956\u7ec6\u80de\u548c\u5e72\u7ec6\u80de\u4e2d\u5b58\u5728\u7684\u7cbe\u786e\u57fa\u56e0\u7f51\u7edc\uff0c\u8fd9\u5bf9\u4e8e\u5f00\u53d1\u51fa\u5728\u57f9\u517b\u76bf\u4e2d\u57f9\u517b\u7ec6\u80de\u4ee5\u6cbb\u7597\u808c\u8089\u75be\u75c5\u7684\u65b9\u6cd5\u81f3\u5173\u91cd\u8981\u3002\u201d<\/div>\n
\u53c2\u8003\u6587\u732e>><\/div>\n
Haibin Xi et al., A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem Cells. Cell Stem Cell(2020)\u00a0<\/div>\n
\u00a0<\/div>\n
\u25a0 \u5408\u6210\u751f\u7269\u5b66 x \u4eba\u5de5\u667a\u80fd<\/div>\n
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5\u670819\u65e5\uff0c\u6e05\u534e\u5927\u5b66\u6c6a\u5c0f\u6211\u8bfe\u9898\u7ec4\u5728 Nucleic Acids\u00a0Research \u53d1\u8868\u5408\u6210\u751f\u7269\u5b66\u7814\u7a76\u6210\u679c\uff0c\u8be5\u9879\u7814\u57fa\u4e8e\u4eba\u5de5\u667a\u80fd\u7b97\u6cd5\uff0c\u5728\u5927\u80a0\u6746\u83cc\u4e2d\u6210\u529f\u5b9e\u73b0\u4e86\u5168\u65b0\u57fa\u56e0\u542f\u52a8\u5b50\u7684\u8bbe\u8ba1\uff0c\u5e76\u4ea7\u751f\u5927\u91cf\u5168\u65b0\u7684\u542f\u52a8\u5b50\uff0c\u5b9e\u9a8c\u9a8c\u8bc1\u6210\u529f\u7387\u8d85\u8fc7 70%\u3002<\/div>\n
\u53c2\u8003\u6587\u732e>><\/div>\n
Ye Wang et al., Synthetic promoter design in Escherichia coli based on a deep generative network,\u00a0Nucleic Acids\u00a0Research(2020)<\/div>\n
\u00a0<\/div>\n
\u25a0\u00a0\u5408\u6210\u751f\u7269\u5b66\u7a81\u7834\uff0c\u53d1\u73b0”\u4e2a\u4f53\u751f\u957f\u5206\u88c2\u65b9\u7a0b\u201d<\/div>\n
\u63ed\u793a\u7ec6\u83cc\u7ec6\u80de\u5927\u5c0f\u7684\u51b3\u5b9a\u56e0\u7d20<\/div>\n
5\u670818\u65e5\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u6df1\u5733\u5148\u8fdb\u6280\u672f\u7814\u7a76\u9662\u3001\u6df1\u5733\u5408\u6210\u751f\u7269\u5b66\u521b\u65b0\u7814\u7a76\u9662\u5218\u9648\u7acb\u7814\u7a76\u7ec4\u5728Nature Microbiology\u53d1\u8868\u7814\u7a76\u6210\u679c\uff0c\u4ee5\u5927\u80a0\u6746\u83cc\u4e3a\u6a21\u5f0f\u751f\u7269\uff0c\u63ed\u79d8\u4e86\u7ec6\u83cc\u5927\u5c0f\u7684\u51b3\u5b9a\u56e0\u7d20\uff0c\u53d1\u73b0\u4e86\u5168\u65b0\u7684\u201c\u4e2a\u4f53\u751f\u957f\u5206\u88c2\u65b9\u7a0b\u201d\uff0c\u4fee\u6b63\u4e86\u8be5\u9886\u57df\u539f\u6709\u7684\u4e24\u5927\u751f\u957f\u6cd5\u5219\uff0c\u5e76\u5bf9\u5408\u6210\u751f\u7269\u5b66\u9886\u57df\u751f\u547d\u4f53\u7406\u6027\u8bbe\u8ba1\u63d0\u4f9b\u4e86\u76f8\u5173\u5efa\u6784\u57fa\u7840\u539f\u7406\u3002<\/div>\n
\u6b63\u5982\u201c\u4f2f\u52aa\u5229\u65b9\u7a0b\u201d\u6307\u5bfc\u4e86\u98de\u673a\u7684\u8bbe\u8ba1\uff1b\u201c\u963f\u57fa\u7c73\u5fb7\u6d6e\u529b\u5b9a\u5f8b\u201d\u63a8\u52a8\u4e86\u6f5c\u8247\u7684\u9762\u4e16\uff1b\u201c\u725b\u987f\u7b2c\u4e8c\u5b9a\u5f8b\u201d\u662f\u4eba\u7c7b\u5f97\u4ee5\u7ff1\u7fd4\u5730\u7403\u5916\u592a\u7a7a\u7684\u91cd\u8981\u7406\u8bba\u57fa\u77f3\uff0c\u5408\u6210\u751f\u7269\u5b66\u7684\u7ec8\u6781\u76ee\u6807\u5c31\u662f\u7406\u6027\u7684\u8bbe\u8ba1\u3001\u6539\u9020\u73b0\u6709\u751f\u547d\u5f62\u5f0f\u6216\u8005\u521b\u9020\u5168\u65b0\u7684\u751f\u547d\u5f62\u5f0f\u4ee5\u6ee1\u8db3\u4eba\u7c7b\u4e0d\u540c\u7684\u9700\u6c42\uff08\u53c2\u8003\u201ciSynBio\u7231\u661f\u535a\u201d\uff09\u3002<\/div>\n
\u53c2\u8003\u6587\u7ae0>><\/div>\n
\u5218\u9648\u7acb\u5b9e\u9a8c\u5ba4\u53c8\u4e00\u4e2a\u516c\u5f0f\u63ed\u79d8\u7ec6\u83cc\u7ec6\u80de\u5927\u5c0f\u7684\u51b3\u5b9a\u56e0\u7d20\uff0c\u63ed\u793a\u5408\u6210\u751f\u7269\u5efa\u6784\u539f\u7406<\/a><\/div>\n
\u53c2\u8003\u6587\u732e>><\/div>\n
Chenli Liu et al., General quantitative relations linking cell growth and the cell cycle in Escherichia coli. Nat Microbiol(2020)<\/div>\n
\u00a0<\/div>\n
\u25a0 \u57fa\u56e0\u7f16\u8f91\u63a7\u5236\u868a\u5b50\u540e\u4ee3\u6027\u522b\u6bd4\u4f8b<\/div>\n
\u9632\u63a7\u75be\u75c5\u4f20\u64ad<\/div>\n
\u6211\u4eec\u77e5\u9053\uff0c\u53ea\u6709\u96cc\u6027\u6606\u866b\u4f20\u64ad\u759f\u75be\u3001\u767b\u9769\u70ed\u548c\u5be8\u5361\u75c5\u6bd2\u7b49\u75be\u75c5\uff1b\u56e0\u6b64\u957f\u671f\u4ee5\u6765\uff0c\u79d1\u5b66\u5bb6\u4e00\u76f4\u5728\u5bfb\u627e\u80fd\u4f7f\u6606\u866b\u540e\u4ee3\u7684\u6027\u522b\u6bd4\u4f8b\u4ea7\u751f\u504f\u5dee\u7684\u63a7\u5236\u65b9\u6cd5\uff0c\u7528\u4e8e\u63a7\u5236\u4f20\u64ad\u759f\u75be\u7b49\u5a92\u4ecb\u3002<\/div>\n
\u8fd1\u65e5\uff0c\u82f1\u56fd\u4f26\u6566\u5e1d\u56fd\u7406\u5de5\u5b66\u9662\u8054\u5408\u7f8e\u56fd\u7ea6\u7ff0\u970d\u666e\u91d1\u65af\u5927\u5b66\u7b49\u56e2\u961f\u5728Nature\u00a0Biotechnology\u4e0a\u53d1\u8868\u7814\u7a76\u6210\u679c\uff0c\u7814\u53d1\u51fa\u57fa\u4e8eCRISPR\u7684\u57fa\u56e0\u9a71\u52a8\u5668\uff08SDGD\uff09\uff0c\u53ef\u4ee5\u63a7\u5236\u5188\u6bd4\u4e9a\u6309\u868a\uff08Anopheles gambiae\u4e2d\u7684\u7537\u6027\u504f\u5411\u6027\u7578\u53d8\u3002\u901a\u8fc7\u6a21\u578b\u9884\u8ba1\uff0cSDGD\u5bf9\u96cc\u6027\u868a\u5b50\u79cd\u7fa4\u7684\u5f71\u54cd\u8f83\u4e4b\u524d\u7814\u7a76\u66f4\u5feb\uff0c\u4ece10-14\u4ee3\u76842.5\uff05\u8d77\u59cb\u7b49\u4f4d\u57fa\u56e0\u9891\u7387\u4e2d\u4ea7\u751f\u4e86\u4ec5\u7537\u6027\u79cd\u7fa4\uff0c\u4e14\u201c\u79cd\u7fa4\u5d29\u6e83\u201d\u6ca1\u6709\u6297\u836f\u6027\u9009\u62e9\u3002<\/div>\n
\u53c2\u8003\u6587\u732e>><\/div>\n
Alekos Simoni et al., A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae,Nature Biotechnology(2020)<\/div>\n
\u5e94\u7528<\/div>\n
\u00a0<\/div>\n
\u25a0\u00a0\u9996\u521b\u553e\u6db2DNA\u7b5b\u67e5HPV\u5bfc\u81f4\u7684\u54bd\u5589\u764c<\/div>\n
\u00a0<\/div>\n\n
\n
\"RmFicvQBAkgBaialRnp913aoLpyaoCFV70tU3JNMu0lFOicHdMRZTkdIx0k9b1MrZu4RttXZCOPHF2GY7akB7sVcQ\"\/<\/figure><\/div>\n\n
\u25b3 \u56fe1\uff1a\u54bd\u5589\u89e3\u5256\u793a\u610f\u56fe<\/div>\n
\uff08\u6765\u6e90\/\u6606\u58eb\u5170\u79d1\u6280\u5927\u5b66\u5b98\u7f51\uff09<\/div>\n
\u6606\u58eb\u5170\u79d1\u6280\u5927\u5b66\u56e2\u961f\u5f00\u53d1\u7684\u4e00\u79cd\u7b80\u5355\u7684\u553e\u6db2DNA\u68c0\u6d4b\u65b9\u6cd5\uff0c\u53ef\u4ee5\u5bf9\u6ca1\u6709\u75c7\u72b6\u548c\u4e34\u5e8a\u8868\u578b\u7684\u4eba\u68c0\u6d4b\u5230\u65e9\u671f\u54bd\u5589\u764c\u3002\u636e\u79f0\u8fd9\u662f\u4e16\u754c\u9996\u521b\u7684\u65e0\u521b\u54bd\u5589\u764c\u68c0\u6d4b\uff0c\u57fa\u4e8e\u553e\u6db2\u4e2d\u7684HPV DNA\u68c0\u6d4b\u3002<\/div>\n
\u5728\u7f8e\u56fd\uff0cHPV\u5bfc\u81f4\u7684\u54bd\u5589\u764c\u5df2\u8d85\u8fc7\u5bab\u9888\u764c\uff0c\u4f46\u4e0e\u5bab\u9888\u764c\u4e0d\u540c\uff0c\u5230\u76ee\u524d\u4e3a\u6b62\u8fd8\u6ca1\u6709\u9488\u5bf9\u8fd9\u79cd\u7c7b\u578b\u7684\u54bd\u5589\u764c\u7684\u7b5b\u67e5\u65b9\u6cd5\u3002<\/div>\n
\u53c2\u8003\u6587\u732e>><\/div>\n
Kai Dun Tang et al.,\u00a0An Occult HPV-Driven Oropharyngeal Squamous Cell Carcinoma Discovered Through a Saliva Test.\u00a0Frontiers in Oncology(2020)<\/div>\n
\u00a0<\/div>\n
\u25a0\u00a0SMA\u57fa\u56e0\u7597\u6cd5Zolgensma\u83b7\u6b27\u76df\u59d4\u5458\u4f1a\u6709\u6761\u4ef6\u6279\u51c6<\/div>\n
5\u670819\u65e5\uff0c\u8bfa\u534e\u65d7\u4e0b\u7684AveXis\u516c\u53f8\u5ba3\u5e03\uff0c\u6b27\u76df\u59d4\u5458\u4f1a\uff08EC\uff09\u6709\u6761\u4ef6\u6279\u51c6\u4e86Zolgensma\u7528\u4e8e\u6cbb\u7597\u7279\u5b9a\u7684SMA\u60a3\u8005\uff1a\u5305\u62ecSMN1\u53cc\u7b49\u4f4d\u57fa\u56e0\u7a81\u53d8\u548c\u4e34\u5e8a\u8bca\u65ad\u4e3a 1\u578b\u76845q SMA\u60a3\u8005\uff1b\u6216SMN1\u53cc\u7b49\u4f4d\u57fa\u56e0\u7a81\u53d8\u4e14SMN2\u62f7\u8d1d\u6570\u6700\u9ad8\u4e3a3\u76845q SMA\u60a3\u8005\u3002<\/div>\n
\u6839\u636e\u88ab\u6279\u51c6\u7684\u7ed9\u836f\u5242\u91cf\u6307\u5bfc\uff0c\u6b64\u6b21\u83b7\u6279\u9002\u7528\u4e8e\u4f53\u91cd\u4e0d\u8d85\u8fc721\u516c\u65a4\u7684SMA\u5a74\u5e7c\u513f\u60a3\u8005\u3002<\/div>\n
\u6b64\u524d\uff0cZolgensma\u5bf9\u4e8e\u75c7\u72b6\u524d\u548c\u6709\u75c7\u72b6\u7684SMA\u60a3\u8005\u663e\u793a\u51fa\u663e\u8457\u3001\u4e14\u5177\u4e34\u5e8a\u610f\u4e49\u7684\u7597\u6548\uff0c\u5305\u62ec\u5ef6\u957f\u65e0\u4e8b\u4ef6\u751f\u5b58\u671f\u548c\u8fbe\u5230\u81ea\u7136\u75c5\u53f2\u4e2d\u8fc4\u4eca\u672a\u89c1\u7684\u8fd0\u52a8\u91cc\u7a0b\u7891\uff0c\u5e76\uff08\u8fd9\u6837\u7684\u6548\u679c\uff09\u5728\u7ed9\u836f\u540e\u5df2\u6301\u7eed5\u5e74\u3002\uff08\u53c2\u8003\u201c\u7f8e\u513fSMA\u5173\u7231\u4e2d\u5fc3\u201d\uff09<\/div>\n
\u00a0<\/div>\n
\u4ea7\u4e1a<\/div>\n
\u25a0\u00a0\u71c3\u77f3\u533b\u5b66\u8d74\u7f8eIPO\uff0c\u62df\u52df\u8d441\u4ebf\u7f8e\u5143<\/div>\n
\u7f8e\u56fd\u4e1c\u90e8\u65f6\u95f45\u670822\u65e5\uff0c\u56fd\u5185\u80bf\u7624\u57fa\u56e0\u68c0\u6d4b\u884c\u4e1a\u4f01\u4e1a\u71c3\u77f3\u533b\u5b66\u5411\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\uff08SEC\uff09\u516c\u5f00\u9012\u4ea4\u4e86\u62db\u80a1\u8bf4\u660e\u4e66\uff08F-1\uff09\uff0c\u7533\u8bf7\u5728\u7eb3\u65af\u8fbe\u514b\u4ea4\u6613\u6240\u4ee5\u201cBNR\u201d\u4e3a\u80a1\u7968\u4ee3\u7801\u6302\u724c\u4e0a\u5e02\u3002<\/div>\n
\u6839\u636e\u62db\u80a1\u4e66\uff0c\u71c3\u77f3\u533b\u5b662017-2019\u5e74\u603b\u8425\u6536\u5206\u522b\u4e3a1.112\u4ebf\u30012.089\u4ebf\u548c3.817\u4ebf\u5143\u4eba\u6c11\u5e01\uff0c2017-2019\u5e74\u5f52\u5c5e\u4e8e\u516c\u53f8\u6240\u6709\u8005\u7684\u4e8f\u635f\u5206\u522b\u4e3a1.313\u4ebf\u30011.775\u4ebf\u548c1.692\u4ebf\u5143\u4eba\u6c11\u5e01\uff1b2020\u5e743\u6708\u672b\uff0c\u8d26\u9762\u8d44\u91d17.22\u4ebf\u5143\u4eba\u6c11\u5e01\u3002\u6b64\u6b21IPO\u627f\u9500\u5546\u5305\u62ecMorgan Stanley\u3001BofA Securities\u3001Cowen\u3001CMBI\u548cTiger Brokers\u3002<\/div>\n
\u00a0<\/div>\n
\u25a0 Thermo Fisher\u62df\u6295\u8d441.8\u4ebf\u7f8e\u5143\u5efa\u75c5\u6bd2\u8f7d\u4f53\u5236\u9020\u5382<\/div>\n
\u5f53\u5730\u65f6\u95f45\u670813\u65e5\uff0cThermo Fisher\u8868\u793a\uff0c\u5c06\u6295\u8d441.8\u4ebf\u7f8e\u5143\u5728\u9a6c\u8428\u8bf8\u585e\u5dde\u65b0\u5efa\u4e00\u4e2a\u751f\u4ea7\u57fa\u5730\uff0c\u5c06\u73b0\u6709\u75c5\u6bd2\u8f7d\u4f53\u5236\u9020\u901a\u91cf\u6269\u5927\u4e00\u500d\uff0c\u4ee5\u652f\u6301\u5bf9\u57fa\u56e0\u7597\u6cd5\u548c\u75ab\u82d7\u65e5\u76ca\u589e\u957f\u7684\u9700\u6c42\u3002\u5de5\u5382\u5360\u573029\u4e07\u5e73\u65b9\u82f1\u5c3a\uff0c\u9884\u8ba1\u5c06\u4e8e2022\u5e74\u5b8c\u5de5\u3002<\/div>\n
\u00a0<\/div>\n
\u25a0 8\u5bb6\u4e2d\u56fdRNA\u4f01\u4e1a\u4e0a\u699cCB Insights<\/div>\n
CB Insights\u8fd1\u65e5\u53d1\u5e03\u5f71\u54cd\u672a\u6765\u76848\u5bb6\u4e2d\u56fdRNA\u4f01\u4e1a\uff0c\u5206\u522b\u662f\uff1a\u745e\u535a\u751f\u7269\u3001\u5723\u8bfa\u751f\u7269\u3001\u4e2d\u7f8e\u745e\u5eb7\u3001\u65af\u5fae\u751f\u7269\u3001\u827e\u535a\u79d1\u6280\u3001\u6df1\u4fe1\u751f\u7269\u3001\u5409\u739b\u57fa\u56e0\u3001\u9510\u535a\u751f\u7269\u3002<\/div>\n
RNA \u7597\u6cd5\u6307\u4ee5 RNA \u4e3a\u57fa\u7840\u7684\u836f\u7269\u6216\u75ab\u82d7\u3002\u4e0a\u4e16\u7eaa 70 \u5e74\u4ee3\uff0c\u53cd\u4e49\u6838\u82f7\u9178\u7684\u6982\u5ff5\u9996\u5148\u88ab\u63d0\u51fa\u300290 \u5e74\u4ee3\uff0cRNA \u5e72\u6270\u6280\u672f\u548c mRNA \u836f\u7269\u7684\u8bbe\u60f3\u76f8\u7ee7\u8ff8\u53d1\uff0c2001 \u5e74\uff0csiRNA \u6280\u672f\u88abScience\u671f\u520a\u8bc4\u4e3a\u5f53\u5e74\u5341\u5927\u6280\u672f\u8fdb\u6b65\u4e4b\u4e00\u3002CureVac\u3001Alnylam\u3001BioNTech\u3001Moderna \u7b49\u516c\u53f8\u76f8\u7ee7\u6210\u7acb\uff0c\u4e13\u6ce8 RNA \u7597\u6cd5\u7684\u5f00\u53d1\u548c\u5e94\u7528\u3002<\/div>\n
\u4ece\u6280\u672f\u4e0a\uff0cCB Insights \u5c06 RNA \u7597\u6cd5\u5206\u4e3a\u4e09\u5927\u7c7b\u522b\uff1a\u00a0<\/div>\n
1\uff09\u4ee5\u6838\u9178\uff08DNA \u6216\u662f RNA\uff09\u4f5c\u4e3a\u9776\u5411\u7684\u7597\u6cd5\uff0c\u8fd9\u5176\u4e2d\u4e3b\u8981\u5305\u62ec\u5355\u94fe\u7684\u53cd\u4e49\u5be1\u6838\u82f7\u9178\u836f\u7269\uff08ASO\uff09\u3001\u53cc\u94fe\u7684RNA\u5e72\u6270\u836f\u7269\uff08RNAi\uff09\u4ee5\u53ca\u5176\u5b83\u5c0f\u5206\u5b50\u836f\u7269\u3002\u800c\u53cc\u94fe RNA \u5e72\u6270\u836f\u7269\u53c8\u4ee5 siRNA\uff08\u5c0f\u5e72\u6270 RNA\uff09\u4ee5\u53ca miRNA\uff08\u5fae\u5c0f RNA\uff09\u4e3a\u4e3b\u3002<\/div>\n
2\uff09\u5229\u7528\u81ea\u8eab\u4e09\u7ef4\u7ed3\u6784\uff0c\u4ee5\u86cb\u767d\u8d28\u4e3a\u9776\u5411\u7684 RNA \u5206\u5b50\u836f\u7269\uff0cRNA \u9002\u914d\u4f53\u836f\u7269\u5c5e\u4e8e\u8fd9\u4e00\u5206\u7c7b\u3002\u00a0<\/div>\n
3\uff09\u4ee5\u7f16\u7801\u86cb\u767d\u8d28\u4e3a\u76ee\u7684 RNA \u7597\u6cd5\uff0c\u8fd9\u5176\u4e2d\u4e3b\u8981\u5305\u62ec mRNA \u836f\u7269\uff08IVT mRNA\uff09\u4ee5\u53ca mRNA \u75ab\u82d7\u7b49\u3002\uff08\u53c2\u8003\u201cDeepTech\u6df1\u79d1\u6280\u201d\uff09<\/div>\n
\u53c2\u8003\u6587\u7ae0>><\/div>\n
8\u5bb6\u4e2d\u56fdRNA\u516c\u53f8\u4e0a\u699c\uff01CB Insights\u9996\u6b21\u53d1\u5e03\u4e2d\u56fdRNA\u4f01\u4e1a\u699c\u5355<\/a><\/div>\n
\u00a0<\/div>\n
\u25a0 \u672c\u5468\u6218\u7565\u5408\u4f5c\u4e8b\u4ef6<\/div>\n
\u3010\u827e\u5fb7\u751f\u7269 x \u5b89\u8fdb\u30115\u670822\u65e5\uff0c\u827e\u5fb7\u751f\u7269\u4e0e\u5168\u7403\u77e5\u540d\u751f\u7269\u6280\u672f\u516c\u53f8\u5b89\u8fdb\uff08Amgen\uff09\u8fbe\u6210\u4f34\u968f\u8bca\u65ad\u6218\u7565\u5408\u4f5c\u3002\u6839\u636e\u534f\u8bae\uff0c\u827e\u5fb7\u751f\u7269\u57fa\u4e8e\u81ea\u4e3b\u4e13\u5229\u6280\u672f\u5f00\u53d1\u7684\u201c\u80ba\u764c\u591a\u57fa\u56e0\u8054\u5408\u68c0\u6d4b\u4ea7\u54c1\u201d\uff08\u827e\u60e0\u5065\u00ae\u5347\u7ea7\u7248\uff09\uff0c\u5c06\u7528\u4e8e\u5b89\u8fdb\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u91cd\u78c5\u9776\u5411\u836f\u7269AMG510\uff08\u9488\u5bf9KRAS\u57fa\u56e0G12C\u7a81\u53d8\u7684\u4e0d\u53ef\u9006\u6291\u5236\u5242\uff09\u5728\u4e2d\u56fd\u7684\u4f34\u968f\u8bca\u65ad\uff0c\u5e76\u5c06\u79ef\u6781\u63a8\u8fdb\u5176\u5728\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u7684\u6ce8\u518c\u5ba1\u6279\u3002<\/div>\n
\u3010\u5409\u56e0\u52a0 x \u5609\u68c0\u533b\u5b66\u30115\u670815\u65e5\uff0c\u5317\u4eac\u5409\u56e0\u52a0\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08\u7b80\u79f0\u201c\u5409\u56e0\u52a0\u201d\uff09\u4e0e\u5e7f\u5dde\u5609\u68c0\u533b\u5b66\u6709\u9650\u516c\u53f8\uff08\u7b80\u79f0\u201c\u5609\u68c0\u533b\u5b66\u201d\uff09\uff0c\u5ba3\u5e03\u53cc\u65b9\u5c06\u5728\u9057\u4f20\u6027\u75be\u75c5\u548c\u80bf\u7624\u57fa\u56e0\u68c0\u6d4b\u9886\u57df\u5f00\u5c55\u6218\u7565\u5408\u4f5c\uff0c\u5171\u5efa\u57fa\u4e8eGene+Seq-200\/2000\u7684\u9057\u4f20\u75c5\u4e0e\u80bf\u7624\u68c0\u6d4b\u4e34\u5e8a\u5e94\u7528\u3002\u89c1\u8bc1\u4eba\u4e3a\u53cc\u65b9\u7684\u6295\u8d44\u4eba\u677e\u79be\u8d44\u672c\u4ee3\u8868\u6768\u747e\u5973\u58eb\u3002<\/div>\n
\u3010\u6cdb\u751f\u5b50 x \u8fbe\u745e\u751f\u7269\u30115\u670814\u65e5\uff0c\u6cdb\u751f\u5b50\u4e0e\u8fbe\u745e\u751f\u7269\u7b7e\u7f72\u6218\u7565\u5408\u4f5c\u534f\u8bae\uff0c\u8fbe\u745e\u751f\u7269\u5c06\u57fa\u4e8e\u6cdb\u751f\u5b50\u57fa\u56e0\u6d4b\u5e8f\u4eea GENETRON S5\uff08\u56fd\u68b0\u6ce8\u51c6\uff1a20193220820\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201cGENETRON S5\u201d\uff09\u5e73\u53f0\uff0c\u5f00\u5c55\u75c5\u539f\u5fae\u751f\u7269\u68c0\u6d4b\u4ea7\u54c1\u7684\u5f00\u53d1\u53ca\u8bd5\u5242\u76d2\u6ce8\u518c\u62a5\u8bc1\u3002\u81f3\u6b64\uff0cGENETRON S5 \u5e73\u53f0\u5df2\u5e7f\u6cdb\u5e94\u7528\u4e8e\u80bf\u7624\u3001\u9057\u4f20\u75c5\u53ca\u75c5\u539f\u5fae\u751f\u7269\u68c0\u6d4b\u7b49\u591a\u4e2a\u9886\u57df\uff0c\u5145\u5206\u4f53\u73b0\u4e86\u8be5\u5e73\u53f0\u7684\u5e94\u7528\u573a\u666f\u591a\u6837\u6027\u548c\u4ea7\u54c1\u7814\u53d1\u5f00\u653e\u6027\u3002<\/div>\n
\u00a0<\/div>\n
\u25a0 \u672c\u5468\u6295\u878d\u8d44\u4e8b\u4ef6<\/div>\n
\u5f53\u5730\u65f6\u95f4\u5e745\u670822\u65e5\uff0c\u7f57\u6c0f\u5b98\u7f51\u5ba3\u5e03\u5df2\u6536\u8d2d\u6d4b\u5e8f\u6280\u672f\u516c\u53f8Stratos Genomics\u516c\u53f8\uff0c\u6b64\u6b21\u6536\u8d2d\u4f7f\u7f57\u6c0f\u5f97\u4ee5\u5229\u7528Stratos Genomics\u72ec\u7279\u7684\u6269\u5c55\u6d4b\u5e8f\uff08SBX\u2122\uff09\u6280\u672f\uff0c\u6765\u52a0\u901f\u5f00\u53d1\u7f57\u6c0f\u7684\u7eb3\u7c73\u5b54\u6d4b\u5e8f\u4eea\uff0c\u7528\u4e8e\u5feb\u901f\u7075\u6d3b\u3001\u7ecf\u6d4e\u9ad8\u6548\u7684\u4e34\u5e8a\u8bca\u65ad\u68c0\u6d4b\u3002\u878d\u8d44\u91d1\u989d\u672a\u62ab\u9732\u3002<\/div>\n
\u5f53\u5730\u65f6\u95f4\u5e745\u670821\u65e5\uff0c\u86cb\u767d\u8d28\u7ec4\u5b66\u516c\u53f8Nautilus Biotechnology\u5ba3\u5e03\u5df2\u5b8c\u62107600\u4e07\u7f8e\u5143B\u8f6e\u878d\u8d44\u3002Vulcan Capital\u9886\u6295\uff0c\u5148\u524d\u7684\u6295\u8d44\u8005AME Cloud Ventures\uff0cAndreessen Horowitz\uff0cBolt\u548cMadrona Venture Group\uff0c\u4ee5\u53ca\u65b0\u6295\u8d44\u8005Perceptive Advisors\uff0cBezos Expeditions\u548cDefy Partners\u8ddf\u6295\u3002<\/div>\n
\u5f53\u5730\u65f6\u95f4\u5e745\u670820\u65e5\uff0c\u57fa\u4e8e\u5408\u6210\u751f\u7269\u5b66\u5bfb\u627e\u836f\u7269\u9776\u6807\u7684\u836f\u7269\u53d1\u73b0\u516c\u53f8Octant\uff0c\u8868\u793a\uff0c\u5df2\u5b8c\u62103000\u4e07\u7f8e\u5143\u7684A\u8f6e\u878d\u8d44\u3002\u7845\u8c37\u98ce\u9669\u6295\u8d44\u516c\u53f8Andreessen Horowitz\u9886\u6295\uff0c8VC\uff0cSV Angel\uff0cAllen\uff06Co\u548c\u5176\u4ed6\u4e00\u4e9b\u672a\u516c\u5f00\u7684\u79c1\u4eba\u6295\u8d44\u8005\u8ddf\u6295\u3002<\/div>\n
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\u00a0<\/div>\n
\u25a0\u00a0Moderna\u516c\u53f8\u8868\u793a\u65b0\u51a0\u75ab\u82d7MRNA-1273\u5b89\u5168\u4e14\u8010\u53d7\u6027\u826f\u597d<\/div>\n
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\u53c2\u8003\u6587\u7ae0>><\/div>\n
https:\/\/investors.modernatx.com\/news-releases\/news-release-details\/moderna-announces-positive-interim-phase-1-data-its-mrna-vaccine?from=timeline&isappinstalled=0<\/div>\n
\u00a0<\/div>\n
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