\u6587\u7ae0 | Nature \u7f16\u8bd1 | \u57fa\u56e0\u6167\u00a0<\/div>\n
\u7f16\u8f91 | Dylan\u00a0\u00a0\u5173\u952e\u8bcd | \u65b0\u51a0\u00a0\u57fa\u56e0<\/div>\n\n
\n![\"RmFicvQBAkgDibicnglLkBISStOlhZwL9aXL9wuClBk2DcrE87vVVaF01z6a2B6t5akcCzEF1v4icEsvibdWmuTYKWQ\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDibicnglLkBISStOlhZwL9aXL9wuClBk2DcrE87vVVaF01z6a2B6t5akcCzEF1v4icEsvibdWmuTYKWQ.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u25b3 \u56fe\uff1a\u5723\u514b\u9c81\u65af\u6cb3\uff08\u00a9 Coolbiere Photograph\/Getty Images\uff09<\/div>\n
\u5212\u91cd\u70b9<\/div>\n
\u89e3\u5c01\u5c06\u5e26\u6765\u65b0\u589e\u75c5\u4f8b<\/div>\n
\u79d1\u5b66\u5bb6\u5df2\u5bf9\u5168\u7403\u7ea632,000\u4e2a\u75c5\u6bd2\u57fa\u56e0\u7ec4\u8fdb\u884c\u4e86\u6d4b\u5e8f\u548c\u5171\u4eab\u3002<\/div>\n
\u901a\u8fc7\u57fa\u56e0\u5e8f\u5217\u6bd4\u5bf9\uff0c\u53ef\u4ee5\u5feb\u901f\u6392\u9664\u6216\u8005\u786e\u5b9a\u65b0\u51a0\u4f20\u64ad\u9014\u5f84<\/div>\n
\u5f53\u83b7\u5f97\u6240\u6709\u75c5\u4f8b\u7684\u57fa\u56e0\u5e8f\u5217\u65f6\uff0c\u66f4\u6709\u53ef\u80fd\u786e\u5b9a\u4e0b\u4e00\u4e2a\u65b0\u589e\u6848\u4f8b\u53d1\u751f\u7684\u4f4d\u7f6e\u3002<\/div>\n
\u76ee\u524d\u901a\u8fc7\u57fa\u56e0\u6d4b\u5e8f\u9632\u63a7\u75ab\u60c5\u7684\u6210\u672c\u4f9d\u7136\u8fc7\u9ad8\u3002<\/div>\n
\u00a0<\/div>\n
\u25a0\u00a0\u65b0\u51a0\u75ab\u60c5\u8fdb\u5165\u4e0b\u9636\u6bb5\uff0c\u57fa\u56e0\u79d1\u6280\u663e\u8eab\u624b<\/div>\n
\u5bf9\u4e8e\u75ab\u60c5\u9632\u63a7\u76f8\u5bf9\u7a33\u5b9a\u7684\u56fd\u5bb6\u800c\u8a00\uff0c\u6b63\u5728\u8fdb\u4e0b\u4e00\u9636\u6bb5\uff1a\u968f\u7740\u89e3\u5c01\u548c\u6d3b\u52a8\u9650\u5236\u7684\u653e\u677e\uff0c\u6709\u53ef\u80fd\u51fa\u73b0\u65b0\u589e\u75c5\u4f8b\u3002\u800c\u57fa\u56e0\u7ec4\u5b66\u5bf9\u4e8e\u5feb\u901f\u8ffd\u8e2a\u548c\u63a7\u5236\u65b0\u589e\u75c5\u4f8b\u7206\u53d1\u81f3\u5173\u91cd\u8981\u3002\u7814\u7a76\u8868\u660e\uff0c\u901a\u8fc7\u4f7f\u7528\u57fa\u56e0\u7ec4\u5b66\u5bf9\u63a5\u89e6\u8005\u8fdb\u884c\u8ffd\u8e2a\u65f6\uff0c\u53d1\u73b0\u5f53\u524d\u65b0\u51a0\u80ba\u708e\u7206\u53d1\u7684\u65f6\u5019\u8d8a\u6765\u8d8a\u77ed\uff0c\u89c4\u6a21\u8d8a\u6765\u8d8a\u5c0f\u3002<\/div>\n
\u00a0<\/div>\n
\u81ea\u4ece\u7b2c\u4e00\u4e2a\u65b0\u51a0\u72b6\u75c5\u6bd2\u7684\u5168\u57fa\u56e0\u7ec4\u5e8f\u5217\u4e8e2020\u5e741\u670811\u65e5\u5728\u7ebf\u5171\u4eab\u4ee5\u6765\uff0c\u79d1\u5b66\u5bb6\u5df2\u5bf9\u6765\u81ea\u4e16\u754c\u5404\u5730\u7684\u7ea632,000\u4e2a\u75c5\u6bd2\u57fa\u56e0\u7ec4\u8fdb\u884c\u4e86\u6d4b\u5e8f\u548c\u5171\u4eab\u3002<\/div>\n
\u6b63\u56e0\u4e3a\u79ef\u7d2f\u5982\u6b64\u5927\u91cf\u7684\u57fa\u56e0\u6570\u636e\uff0c\u4ee5\u53ca\u968f\u7740\u5728\u4e0d\u540c\u5730\u533a\u75c5\u6bd2\u4f20\u64ad\u7684\u8fdb\u5c55\uff0c\u5f62\u6210\u4e86\u72ec\u7279\u7684\u5bb6\u7cfb\u3002\u901a\u8fc7\u5e8f\u5217\u6bd4\u5bf9\uff0c\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u5feb\u901f\u6392\u9664\u4e24\u4e2a\u5e8f\u5217\u4e0d\u5339\u914d\u7684\u4f20\u64ad\u9014\u5f84\uff0c\u6216\u8005\u5c06\u53ef\u80fd\u7684\u60c5\u51b5\u8054\u7cfb\u8d77\u6765\uff0c\u4ece\u800c\u8ffd\u8e2a\u5176\u6240\u5728\u56fd\u5bb6\u7684\u65b0\u51a0\u75ab\u60c5\u7206\u53d1\u7684\u8d77\u6e90\u548c\u4f20\u64ad\u65f6\u95f4\u3002<\/div>\n
\u00a0<\/div>\n
\u745e\u5178\u54e5\u5fb7\u5821\u5168\u7403\u751f\u7269\u591a\u6837\u6027\u4e2d\u5fc3\u7684\u751f\u7269\u4fe1\u606f\u5b66\u987e\u95eeGytis Dudas\u8bf4\uff1a\u201c\u5728\uff08\u65b0\u589e\uff09\u6848\u4f8b\u8f83\u5c11\u7684\u60c5\u51b5\u4e0b\uff0c\u57fa\u56e0\u7ec4\u5b66\u53ef\u4ee5\u5f88\u5feb\u7684\u5206\u6790\u6837\u672c\u4fe1\u606f\u5e76\u80fd\u6307\u5bfc\u7cbe\u51c6\u7684\u5e72\u9884\u63aa\u65bd\u201d\u3002<\/div>\n
\u5728\u90e8\u5206\u5730\u533a\uff08\u4f8b\u5982\u65b0\u897f\u5170\u548c\u6fb3\u5927\u5229\u4e9a\u7684\u4e00\u4e2a\u5dde\uff09\uff0c\u5728\u65b0\u51a0\u5927\u6d41\u884c\u521d\u671f\u6295\u5165\u57fa\u56e0\u7ec4\u6d4b\u5e8f\uff0c\u540e\u9762\u53d1\u751f\u75c5\u4f8b\u6570\u4e5f\u76f8\u5bf9\u8f83\u5c11\u3002\u82f1\u7f8e\u7b49\u56fd\u7684\u79d1\u5b66\u5bb6\u4e5f\u5bf9\u65b0\u51a0\u6837\u672c\u8fdb\u884c\u57fa\u56e0\u7ec4\u6d4b\u5e8f\uff0c\u7528\u6765\u76d1\u6d4b\u6269\u6563\u4ee5\u53ca\u786e\u5b9a\u67d0\u4e9b\u8ddf\u8e2a\u5931\u8d25\u7684\u75c5\u4f8b\u7684\u6765\u6e90\u3002\u4f46\u662f\uff0c\u5728\u65b0\u51a0\u8bca\u65ad\u68c0\u6d4b\u53d7\u9650\u7684\u5730\u65b9\uff0c\u57fa\u56e0\u7ec4\u6570\u636e\u4e2d\u4e5f\u5c31\u5b58\u5728\u7a7a\u767d\u3002<\/div>\n
\u00a0<\/div>\n
\u25a0\u00a0\u65b0\u51a0\u6837\u672c\u7684\u5168\u9762\u6d4b\u5e8f\uff0c\u6eaf\u6e90\u611f\u67d3\u6e90<\/div>\n
\u5728\u7b2c\u4e00\u4f8b\u6765\u81ea\u6b66\u6c49\u7684\u75c5\u4f8b\u4e8e1\u670819\u65e5\u5230\u8fbe\u6fb3\u5927\u5229\u4e9a\u4e4b\u524d\uff0c\u58a8\u5c14\u672c\u5b9e\u9a8c\u5ba4\uff08\u6b64\u524d\u5de5\u4f5c\u662f\u8c03\u7814\u98df\u6e90\u6027\u75be\u75c5\u7206\u53d1\uff09\u7684\u7814\u7a76\u4eba\u5458\u5c31\u5f00\u59cb\u51c6\u5907\u5bf9\u7ef4\u591a\u5229\u4e9a\u5dde\u7684\u65b0\u51a0\u75c5\u6bd2\u57fa\u56e0\u7ec4\u8fdb\u884c\u6d4b\u5e8f\u3002<\/div>\n
\u201c\u5f53\u65f6\uff0c\u6211\u4eec\u5c31\u8bf4\u6211\u4eec\u8981\u5bf9\u6bcf\u4e00\u4e2a\u9633\u6027\u75c5\u4f8b\u8fdb\u884c\u6d4b\u5e8f\u3002\u201d\u6765\u81ea\u58a8\u5c14\u672c\u5f7c\u5f97\u00b7\u591a\u5c14\u8482\u611f\u67d3\u4e0e\u514d\u75ab\u7814\u7a76\u6240\uff0c\u4e00\u4e2a\u5fae\u751f\u7269\u8bca\u65ad\u90e8\u95e8\u4e0b\u5c5e\u7684\u516c\u5171\u536b\u751f\u5b9e\u9a8c\u5ba4\u7684\u751f\u7269\u4fe1\u606f\u5b66\u5bb6Torsten Seemann\u8bf4\u9053\u3002<\/div>\n
\u5230\u76ee\u524d\u4e3a\u6b62\uff0cSeemann\u7684\u5c0f\u7ec4\u5df2\u5bf9\u8be5\u5dde\u5927\u7ea61,700\u4f8b\u75c5\u4f8b\u4e2d\u7684\u56db\u5206\u4e4b\u4e09\u8fdb\u884c\u4e86\u6d4b\u5e8f\uff0c\u76f8\u6bd4\u4e4b\u4e0b\uff0c2014-2016\u5e74\u897f\u975e\u57c3\u535a\u62c9\u611f\u67d3\u75c5\u4f8b\u4ec5\u67095\uff05\uff081,610\u4e2a\u6837\u672c\uff09\u8fdb\u884c\u4e86\u6d4b\u5e8f\u3002<\/div>\n
\u75c5\u6bd2\u57fa\u56e0\u5e8f\u5217\u6570\u636e\u5e2e\u52a9\u90e8\u5206\u533b\u62a4\u4eba\u5458\u67e5\u660e\u771f\u5b9e\u7684\u4f20\u67d3\u6e90\uff0c\u662f\u5728\u793e\u4ea4\u6d3b\u52a8\u4e2d\u800c\u4e0d\u662f\u4ece\u533b\u9662\u7684\u60a3\u8005\u90a3\u91cc\u611f\u67d3\u4e86\u8be5\u75c5\u6bd2\u3002Seemann\u8bf4\uff1a\u201c\u5982\u679c\u6ca1\u6709\u57fa\u56e0\u7ec4\u5b66\uff0c\u53ea\u6709\u9762\u8bca\uff0c\u60a8\u5c06\u6c38\u8fdc\u65e0\u6cd5\u5206\u8fa8\u3002\u201d<\/div>\n
\u00a0<\/div>\n
\u25a0 \u57fa\u56e0\u5e8f\u5217\u9884\u6d4b\u4e0b\u4e00\u4e2a\u65b0\u589e\u6848\u4f8b\u53d1\u751f\u7684\u4f4d\u7f6e<\/div>\n
\u968f\u7740\u7ef4\u591a\u5229\u4e9a\u5dde\u7684\u9010\u6b65\u89e3\u5c01\u800c\u51fa\u73b0\u65b0\u75c5\u4f8b\uff0cSeemann\u7684\u5c0f\u7ec4\u6b63\u5728\u51c6\u5907\u4f7f\u7528\u57fa\u56e0\u7ec4\u6570\u636e\u786e\u5b9a\u7684\u65b0\u589e\u75c5\u4f8b\u7684\u6765\u6e90\u3002\u5f53\u65c5\u884c\u6062\u590d\u65f6\uff0c\u65b0\u7684\u611f\u67d3\u75c5\u4f8b\u53ef\u80fd\u51fa\u73b0\uff0c\u90a3\u65f6\u57fa\u56e0\u7ec4\u6570\u636e\u5c06\u663e\u5f97\u5c24\u5176\u91cd\u8981\u3002\u56e0\u4e3a\u5728\u8fc7\u53bb\u7684\u4e24\u4e2a\u6708\u4e2d\uff0c\u75c5\u6bd2\u57fa\u56e0\u7ec4\u5c06\u53d1\u751f\u8db3\u591f\u591a\u7684\u7a81\u53d8\uff0c\u4e00\u65e6\u5f97\u5230\u57fa\u56e0\u5e8f\u5217\uff0c\u5c31\u53ef\u4ee5\u533a\u5206\u4ed6\u4eec\u662f\u5426\u6765\u81ea\u8be5\u5dde\u4ee5\u5916\u7684\u5730\u533a\u3002<\/div>\n
\u65b0\u897f\u5170\u6b63\u5728\u5bf9\u65b0\u51a0\u75c5\u4f8b\u5168\u9762\u6d4b\u5e8f\uff0c\u76ee\u6807\u662f\u5c0670\uff05\u4ee5\u4e0a\u7684\u4eba\u5c3d\u53ef\u80fd\u5730\u83b7\u5f97\u5b8c\u6574\u7684\u56fe\u8c31\uff0c\u76ee\u524d\u5df2\u5bf9\u8be5\u56fd1,154\u4f8b\u62a5\u544a\u75c5\u4f8b\u4e2d\u768425\uff05\u8fdb\u884c\u4e86\u6d4b\u5e8f\u3002\u73af\u5883\u79d1\u5b66\u7814\u7a76\u6240\u7684\u9996\u5e2d\u751f\u7269\u4fe1\u606f\u5b66\u5bb6Joep de Ligt\u8868\u793a\uff0c\u5f53\u83b7\u5f97\u6240\u6709\u5e8f\u5217\u65f6\uff0c\u7814\u7a76\u4eba\u5458\u66f4\u6709\u53ef\u80fd\u786e\u5b9a\u4e0b\u4e00\u4e2a\u65b0\u589e\u6848\u4f8b\u53d1\u751f\u7684\u4f4d\u7f6e\u3002<\/div>\n
\u00a0<\/div>\n
\u56e0\u4e3a\u82f1\u56fd\u7684\u65b0\u51a0\u75c5\u4f8b\u5f88\u591a\uff08\u7f16\u8005\u6ce8\uff1a\u622a\u6b625\u670830\u65e5\u7d2f\u8ba1\u75c5\u4f8b\u8d85\u8fc721.7\u4e07\u4f8b\uff09\uff0c\u82f1\u56fd\u4e8e3\u6708\u6210\u7acb\u4e86COVID-19 Genomics UK\u8054\u76df\uff08\u7f16\u8005\u6ce8\uff1a\u82f1\u56fd\u8ba1\u5212\u5f00\u5c55\u5bf93.5\u4e07\u65b0\u51a0\u60a3\u8005\u7684\u57fa\u56e0\u6d4b\u5e8f\u8ba1\u5212\uff09\u3002\u4f2f\u660e\u7ff0\u5927\u5b66\u7684\u751f\u7269\u4fe1\u606f\u5b66\u5bb6Nick Loman\u8bf4\uff0c\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u8054\u76df\u5df2\u7ecf\u5bf920,000\u4e2a\u75c5\u6bd2\u57fa\u56e0\u7ec4\u8fdb\u884c\u4e86\u6d4b\u5e8f\uff0c\u5360\u8be5\u56fd\u5b9e\u9a8c\u5ba4\u786e\u8bca\u75c5\u4f8b\u7684\u8fd110\uff05\u3002<\/div>\n
Nick Loman\u8bf4\uff0c\u56e0\u4e3a\u75c5\u4f8b\u6570\u592a\u591a\uff08\u622a\u81f35\u670827\u65e5\uff0c\u5df2\u786e\u8bca\u7684\u611f\u67d3\u75c5\u4f8b\u63a5\u8fd1265,000\uff09\uff0c\u82f1\u56fd\u6ca1\u6709\u50cf\u65b0\u897f\u5170\u90a3\u6837\u8bbe\u5b9a70%\u76ee\u6807\uff0c\u800c\u662f\u4ece\u82f1\u56fd\u5404\u5730\u62bd\u53d6\u5177\u6709\u4ee3\u8868\u6027\u7684\u6837\u672c\uff0c\u4ee5\u652f\u6301\u6d41\u884c\u75c5\u5b66\u8c03\u67e5\u3002<\/div>\n
\u00a0<\/div>\n
\u25a0\u00a0\u57fa\u56e0\u6d4b\u5e8f\u9632\u63a7\u4f20\u67d3\u75c5\u7684\u5c40\u9650\u6027<\/div>\n
Joep de Ligt\u8bf4\uff0c\u5229\u7528\u57fa\u56e0\u7ec4\u5b66\u5e94\u5bf9\u4f20\u67d3\u75c5\u7206\u53d1\uff0c\u5728\u67d0\u79cd\u7a0b\u5ea6\u4e0a\u5b58\u5728\u5c40\u9650\u6027\u3002\u4f8b\u5982\uff0c\u7ecf\u5386\u65e0\u75c7\u72b6\u611f\u67d3\u7684\u4eba\u4e0d\u592a\u53ef\u80fd\u63a5\u53d7\u65b0\u51a0\u6838\u9178\u7b5b\u67e5\uff08\u7f16\u8005\uff1a\u8fd9\u70b9\u5f88\u8d5e\u53f9\u6211\u56fd\u6b66\u6c49\u5b9e\u884c\u5168\u5458\u7b5b\u67e5\uff09<\/div>\n
\u901a\u8fc7\u57fa\u56e0\u6570\u636e\u8fdb\u884c\u76d1\u6d4b\uff0c\u9700\u8981\u4f9d\u8d56\u5e7f\u6cdb\u7684\u65b0\u7b5b\u8bca\u65ad\u68c0\u6d4b\u6765\u83b7\u5f97\u5e8f\u5217\u3002\u82f1\u56fd\u7684\u65b0\u51a0\u75c5\u4f8b\u5f88\u591a\uff0c\u867d\u7136\u6b63\u9010\u6b65\u589e\u52a0\u65b0\u51a0\u8bca\u65ad\uff0c\u4f46\u901f\u5ea6\u8f83\u6162\uff0c\u5b58\u5728\u90e8\u5206\u75c5\u4f8b\u6ca1\u6709\u88ab\u62bd\u6837\u5230\u7684\u53ef\u80fd\uff0cNick Loman\u8c08\u9053\u3002\u540c\u65f6\uff0c\u56fd\u9645\u65c5\u884c\u6062\u590d\u540e\uff0c\u5168\u7403\u57fa\u56e0\u7ec4\u76d1\u6d4b\u5c06\u663e\u5f97\u5c24\u4e3a\u91cd\u8981\u3002<\/div>\n
\u6fb3\u5927\u5229\u4e9a\u56fd\u7acb\u5927\u5b66\u7684\u6d41\u884c\u75c5\u5b66\u5bb6Meru Sheel\u8bf4\uff0c\u4f7f\u7528\u57fa\u56e0\u7ec4\u5206\u6790\u6765\u8fdb\u884c\u8ffd\u8e2a\u4f20\u67d3\u75c5\u6e90\u548c\u4f20\u64ad\uff0c\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u4ec5\u9650\u4e8e\u9ad8\u6536\u5165\u56fd\u5bb6\u3002\u5f88\u671f\u5f85\u4e9a\u592a\u5730\u533a\u8d44\u6e90\u6709\u9650\u7684\u56fd\u5bb6\uff0c\u4e5f\u80fd\u5c06\u57fa\u56e0\u7ec4\u5b66\u4f5c\u4e3a\u5e94\u5bf9\u75ab\u60c5\u7684\u5de5\u5177\uff0c\u5c31\u50cf\u5728\u57c3\u535a\u62c9\u75ab\u60c5\u7206\u53d1\u65f6\uff0c\u5728\u521a\u679c\u3001\u585e\u62c9\u5229\u6602\u548c\u51e0\u5185\u4e9a\u7684\u60c5\u5f62\u4e00\u6837\u3002<\/div>\n
\u00a0<\/div>\n
\u53c2\u8003\u8d44\u6599\uff1a<\/div>\n
1. Zhang, Y.-Z. & Holmes, E. C. Cell 181, 223\u2013227 (2020)<\/div>\n
2. Stevens, E. et al. Front. Microbiol. 8, 808 (2017)<\/div>\n
3. Caly, L. et al. Med. J. Aust. https:\/\/doi.org\/10.5694\/mja2.50569 (2020)<\/div>\n
4. Seemann, T. et al. Preprint available at MedRxiv https:\/\/doi.org\/10.1101\/2020.05.12.20099929 (2020)<\/div>\n
5. Dudas, G. et al. Nature 544, 309\u2013315 (2017)<\/div>\n
6.\u00a0Jon Cohen\uff0c Chinese researchers reveal draft genome of virus implicated in Wuhan pneumonia outbreak\uff0cScience\uff082020\uff09<\/div>\n
7. \u65b0\u51a0\u75c5\u6bd2\u6570\u636e\u5171\u4eab\u7f51\u7ad9\uff1ahttps:\/\/www.gisaid.org<\/div>\n
8.\u00a0https:\/\/www.nature.com\/articles\/d41586-020-01573-5<\/div>\n
\u00a0<\/div>\n
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<\/figure><\/div>\n\n
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