{"id":9045,"date":"2020-08-26T14:27:45","date_gmt":"2020-08-26T06:27:45","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&#038;mid=100015770&#038;idx=1&#038;sn=62af0b457de27fb47cedab99a80d5fbb&#038;chksm=6b714c2d5c06c53b4126bd1a279d62e2a914bebd33d0a0ded820ddef22f71be07cdee7696067#rd"},"modified":"2026-04-08T09:46:21","modified_gmt":"2026-04-08T01:46:21","slug":"515451","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2020\/08\/26\/515451\/","title":{"rendered":"\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\uff0c\u5f00\u542fNGS\u80bf\u7624\u5355\u7ec6\u80de\u8bca\u65ad\u65b0\u5f81\u7a0b"},"content":{"rendered":"<p><!-- wechat_content_hash: 36386a8fd615a155 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\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u00a0\u80bf\u7624\u8bca\u65ad<\/div>\n<div>\u00a0<\/div>\n<div>\u4e00\u3001\u88ab\u5ffd\u89c6\u7684\u6b63\u5728\u4e34\u5e8a\u5e94\u7528\u9636\u6bb5\u7684\u5355\u7ec6\u80deDNA\u6d4b\u5e8f<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBiaYibRTibib1X4zdUiaOYboZpWiaN5ibQUosrMicDrsWtYhSOVtuNZk5PYFe437LgSRCGpWjBmJgtpVzyuA.png\" alt=\"RmFicvQBAkgBiaYibRTibib1X4zdUiaOYboZpWiaN5ibQUosrMicDrsWtYhSOVtuNZk5PYFe437LgSRCGpWjBmJgtpVzyuA\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe1\uff1aNature\u7279\u8bbe\u5355\u7ec6\u80de\u4e13\u520a\uff08\u6765\u6e90\/Nature\uff0c\u6d5a\u60e0\u751f\u7269\uff09<\/div>\n<div>2017\u5e747\u6708\uff0cNature\u7279\u8bbe\u5355\u7ec6\u80de\u4e13\u520a\uff0c\u5728\u5176\u4e2d\u7684\u91cd\u78c5\u7efc\u8ff0\u6587\u7ae0\u4e2d\u63d0\u5230\uff1a\u672a\u676510\u5e74\uff0c\u5355\u7ec6\u80de\u57fa\u56e0\u7ec4\u5b66\u68c0\u6d4b\u5c06\u6210\u4e3a\u4e34\u5e8a\u7684\u5e38\u89c4\u68c0\u6d4b\u9879\u76ee\u3002\u76ee\u524d\uff0c\u7531\u4e8e\u5e02\u573a\u6559\u80b2\u7684\u6ede\u540e\u6027\uff0c\u4e1a\u754c\u6240\u79f0\u7684\u5355\u7ec6\u80de\u6d4b\u5e8f\u5f80\u5f80\u6307\u7684\u662f\u4ee510x Genomics\u4ee3\u8868\u7684\u9ad8\u901a\u91cf\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff0c\u800c\u5ffd\u89c6\u4e86\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\uff1b\u7136\u800c\uff0c\u524d\u8005\u4ec5\u5e94\u7528\u4e8e\u79d1\u7814\uff0c\u540e\u8005\u5728\u80bf\u7624\u53ca\u751f\u6b96\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u7684\u4e34\u5e8a\u4ef7\u503c\u53ca\u5176\u6f5c\u529b\uff0c\u662f\u8574\u542b\u5b9d\u85cf\u7684\u84dd\u6d77\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u8fd1\u5e74\uff0c\u56fd\u9645\u8d44\u672c\u6301\u7eed\u52a0\u7801\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u3002\u4f8b\u5982\uff0c\u4eca\u5e741\u6708\uff0c\u5355\u7ec6\u80de\u5168\u57fa\u56e0\u7ec4\u6269\u589e\u6280\u672f\u516c\u53f8BioSkryb\u83b7\u5f971150\u4e07\u7f8e\u5143\u79cd\u5b50\u8f6e\u878d\u8d44\uff1b8\u6708\uff0cMission Bio\u83b7\u5f97\u5b89\u6377\u4f26\u548cLabCorp\u7b49\u6295\u8d44\u7684C\u8f6e7000\u4e07\u7f8e\u5143\uff0c\u63a8\u52a8\u5176\u9776\u5411\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u548c\u591a\u7ec4\u5b66\u68c0\u6d4b\u5e73\u53f0\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u4e8c\u3001\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u6bd4RNA\u6d4b\u5e8f\u66f4\u65e9\u8fdb\u5165\u4e34\u5e8a<\/div>\n<div>\u5728\u8c08\u5230\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u6280\u672f\u4e4b\u524d\uff0c\u6211\u4eec\u5148\u770b\u770b\u5206\u5b50\u751f\u7269\u7814\u7a76\u548c\u5e94\u7528\u7684\u6838\u5fc3\u5b9a\u5f8b\u2014\u2014\u4e2d\u5fc3\u6cd5\u5219\u3002\u5bf9\u4e8e\u5927\u591a\u6570\u751f\u7269\u6765\u8bf4\uff0c\u5c24\u5176\u662f\u667a\u4eba\uff08Homo sapiens\uff09\uff0c\u5982\u679c\u8bf4RNA\u662f\u751f\u547d\u9057\u4f20\u4fe1\u606f\u7684\u201c\u4f20\u8bdd\u7b52\u201d\uff0cDNA\u5219\u662f\u50a8\u5b58\u751f\u547d\u9057\u4f20\u7684\u6700\u539f\u59cb\u4fe1\u606f\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBiaYibRTibib1X4zdUiaOYboZpWnCZZU4ltvMdQtdbsAiaQDIrQhacorrfFFEBC4f8B2sbBePumaTfWh4A.png\" alt=\"RmFicvQBAkgBiaYibRTibib1X4zdUiaOYboZpWnCZZU4ltvMdQtdbsAiaQDIrQhacorrfFFEBC4f8B2sbBePumaTfWh4A\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe2\uff1a\u4e2d\u5fc3\u6cd5\u5219\uff08\u6765\u6e90\/\u516c\u5f00\u8d44\u6599 \uff09<\/div>\n<div>\u5355\u7ec6\u80de\u6d4b\u5e8f\uff0c\u5206\u4e3a\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\uff08\u5355\u7ec6\u80de\u57fa\u56e0\u7ec4\u6d4b\u5e8f\uff09\u548c\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff08\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\uff09\u3002\u6839\u636e\u4e2d\u5fc3\u6cd5\u5219\uff0c\u86cb\u767d\u7684\u68c0\u6d4b\u76f8\u5f53\u4e8e\u68c0\u6d4b\u76d6\u597d\u7684\u697c\u623f\uff08\u529f\u80fd\u5355\u4f4d\uff09\uff0c\u5728\u7ec4\u7ec7\u548c\u8131\u843d\u7ec6\u80de\u4e0a\uff0c\u8fc7\u53bb\u51e0\u5341\u5e74\u6765\uff0c\u5df2\u7ecf\u53d1\u5c55\u4e86\u591a\u8fbe\u51e0\u767e\u79cd\u68c0\u6d4b\u86cb\u767d\u7684\u514d\u75ab\u7ec4\u5316\u548c\u514d\u75ab\u8367\u5149\u8bd5\u5242\u83b7\u6279\uff0c\u88ab\u5e7f\u6cdb\u7528\u4e8e\u80bf\u7624\u7684\u9274\u5b9a\u548c\u5206\u7c7b\uff1bRNA\u68c0\u6d4b\u5c31\u50cf\u68c0\u6d4b\u5728\u697c\u623f\u548c\u84dd\u56fe\u4e2d\u95f4\u7684\u201c\u811a\u624b\u67b6\u201d\u9636\u6bb5\uff0cDNA\u68c0\u6d4b\u76f8\u5f53\u4e8e\u68c0\u6d4b\u76d6\u623f\u5b50\u7684\u201c\u84dd\u56fe\u201d\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u5355\u7ec6\u80deRNA\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\u6280\u672f\u7531\u6c64\u5bcc\u916c\u6559\u6388\u53d1\u660e\uff1b\u968f\u540e\u4ee510x Genomics\u4e3a\u4ee3\u8868\u7684\u4f01\u4e1a\u53d1\u660e\u4e86\u9ad8\u901a\u91cf\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u6280\u672f\u3002\u4e3b\u6d41\u7684\u9ad8\u901a\u91cf\u5355\u7ec6\u80deRNA\u5168\u8f6c\u5f55\u7ec4\u9884\u6269\u589e\u6280\u672f\uff0c\u901a\u8fc7barcode\u62c6\u5206\u7ec6\u80de\u65f6\u53ea\u80fd\u83b7\u53d6\u8f6c\u5f55\u672c3\u2019\u7aef\u6570\u636e\uff0c\u53ea\u9002\u7528\u4e8e\u5206\u6790\u57fa\u56e0\u8868\u8fbe\u91cf\uff0c\u68c0\u6d4b\u8f83\u5c11\u6570\u91cf\u7684\u57fa\u56e0 \uff081000-2000\u4e2a\u57fa\u56e0\uff09\uff0c\u4e0d\u6ee1\u8db3\u5206\u6790\u57fa\u56e0\u8f6c\u5f55\u672c\u5168\u957f\u3002\u540c\u65f6\u5bf9\u4e8e\u80bf\u7624\u7ec4\u7ec7\uff0c RNA\u68c0\u6d4b\u7528\u4e8e\u8bca\u65ad\u7f3a\u4e4f\u5bf9\u5e94\u7684\u201c\u91d1\u6807\u51c6\u201d\u3002\u56e0\u6b64\uff0c\u76ee\u524d\u7684\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u6280\u672f\u4e3b\u8981\u504f\u91cd\u4e8e\u57fa\u7840\u79d1\u5b66\u7814\u7a76\uff0c\u5728\u4e34\u5e8a\u4e0a\u5e94\u7528\u53d7\u9650\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u800c\u80bf\u7624\u5355\u7ec6\u80de\u7684DNA\u68c0\u6d4b\u548cctDNA\u7684\u68c0\u6d4b\u7c7b\u4f3c\uff0c\u90fd\u5c5e\u4e8e\u80bf\u7624\u7684\u5fae\u91cfDNA\u68c0\u6d4b\uff0c\u901a\u8fc7\u548c\u201c\u91d1\u6807\u51c6\u201d\u2014\u2014\u80bf\u7624\u7ec4\u7ec7DNA\u68c0\u6d4b\u7684\u4e00\u81f4\u6027\u5bf9\u6bd4\uff0c\u6210\u4e3a\u8865\u5145\u80bf\u7624\u7ec4\u7ec7\u68c0\u6d4b\u7684\u7a00\u6709DNA\u68c0\u6d4b\u65b9\u6cd5\uff0c\u5e94\u7528\u4e8e\u8f85\u52a9\u8bca\u65ad\u548c\u4f34\u968f\u8bca\u65ad\u7b49\uff0c\u8fd1\u51e0\u5e74\u5728\u4e34\u5e8a\u4e0a\u7684\u5e94\u7528\u4e0d\u65ad\u83b7\u5f97FDA\u548cNMPA\u8ba4\u53ef\u3002<\/div>\n<div>\u80bf\u7624\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u6280\u672f\u5e94\u7528\u4e8e\u4e34\u5e8a\u8bca\u65ad\u7684\u96be\u5ea6\u8f83\u9ad8\uff0c\u9700\u8981\u7a81\u7834\u4e00\u7cfb\u5217\u74f6\u9888\u73af\u8282\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u4e09\u3001\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u7684\u4ea7\u4e1a\u5316\u52a0\u901f<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/mmbiz.qlogo.cn\/mmbiz_png\/RmFicvQBAkgBiaYibRTibib1X4zdUiaOYboZpWRlN9aelZU9v6rCOXRldrbJYWcGM5m2O7U37s1xfeMPY48KnBzW0Qug\/0?wx_fmt=png\" alt=\"0?wx_fmt=png\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe3\uff1aCTC\u5206\u6790\u80bf\u7624\u5f02\u8d28\u6027<\/div>\n<div style=\"text-align: center;\">\uff08\u6765\u6e90\/doi:10.1038\/s41568-019-0180-2\uff09<\/div>\n<div>\u901a\u8fc7\u5355\u7ec6\u80de\u6280\u672f\uff0c\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u5206\u5b50\u5206\u6790\u53ef\u4ee5\u5bf9\u80bf\u7624\u5f02\u8d28\u6027\u8fdb\u884c\u5b9a\u6027\u548c\u76d1\u6d4b\uff0c\u800c\u5e38\u89c4\u7ec4\u7ec7\u6d4b\u5e8f\uff08Bulk Sequencing\uff09\u65e0\u6cd5\u63ed\u793a\u8fd9\u4e9b\u5dee\u5f02\u3002\u80bf\u7624\u5355\u7ec6\u80de\u6d4b\u5e8f\u53ef\u4ee5\u63d0\u4f9b\u66f4\u4e30\u5bcc\u7684DNA\u3001RNA\u3001\u86cb\u767d\u8d28\u548c\u4ee3\u8c22\u7269\u4fe1\u606f\uff0c\u4e3a\u66f4\u7cbe\u51c6\u5730\u8bca\u65ad\u548c\u53d1\u73b0\u764c\u75c7\u8f6c\u79fb\u8d77\u59cb\u7ec6\u80de\uff08metastasis-initiating cells\uff09\u7b49\u5e26\u6765\u5168\u65b0\u7684\u5de5\u5177\u3002\u00a0<\/div>\n<div>\u80bf\u7624\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u7684\u4e00\u822c\u5de5\u4f5c\u6d41\u7a0b\u6982\u8ff0\u5982\u4e0b\uff1a<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBiaYibRTibib1X4zdUiaOYboZpWteOwQgPnHqOgAnwSEtpbiaIZZRlzNGadgO5S0f0zjrFGuzjXYvwHH1w.png\" alt=\"RmFicvQBAkgBiaYibRTibib1X4zdUiaOYboZpWteOwQgPnHqOgAnwSEtpbiaIZZRlzNGadgO5S0f0zjrFGuzjXYvwHH1w\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe4\uff1a\u80bf\u7624\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u5de5\u4f5c\u6d41\u7a0b\uff08\u6765\u6e90\/\u57fa\u56e0\u6167\uff09<\/div>\n<div>\u5176\u4e2d\u80bf\u7624\u5355\u7ec6\u80de\u7684\u9274\u5b9a\u3001\u81ea\u52a8\u7684\u5206\u9009\/\u5206\u79bb\u3001\u4ee5\u53ca\u80bf\u7624\u5355\u7ec6\u80deWGA\uff08\u5168\u57fa\u56e0\u7ec4\u6269\u589e\uff09\u90fd\u5b58\u5728\u6280\u672f\u7684\u6311\u6218\u3002\u89e3\u51b3\u8fd9\u4e9b\u96be\u9898\uff0c\u624d\u80fd\u4e3a\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u8fdb\u5165\u4e34\u5e8a\u94fa\u5e73\u9053\u8def\uff0c\u5c06\u4e3a\u80bf\u7624\u8bca\u65ad\u5e26\u6765\u524d\u6240\u672a\u6709\u7684\u5206\u8fa8\u7387\uff0c\u4e3aNGS\u548c\u6db2\u4f53\u6d3b\u68c0\u5e26\u6765\u65b0\u7684\u673a\u9047\u3002<\/div>\n<div>\u8fd1\u5e74\uff0c\u80bf\u7624\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u6280\u672f\u6b63\u5728\u53d6\u5f97\u4e00\u7cfb\u5217\u7a81\u7834\uff1a<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBiaYibRTibib1X4zdUiaOYboZpWEpvic9ibMLKkvBDD0icgd9vlUOO4xwicmia3QBq1fjs6oPticnCUndo3iaMyg.png\" alt=\"RmFicvQBAkgBiaYibRTibib1X4zdUiaOYboZpWEpvic9ibMLKkvBDD0icgd9vlUOO4xwicmia3QBq1fjs6oPticnCUndo3iaMyg\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe5\uff1a\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u6280\u672f\u56de\u987e\uff08\u6765\u6e90\/\u57fa\u56e0\u6167\u6574\u7406\uff09<\/div>\n<div>\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u6280\u672f\u5728\u4e0b\u6e38\u5e94\u7528\u5f00\u53d1\u9886\u57df\u4e3b\u8981\u5305\u62ec\u751f\u6b96\u5065\u5eb7\u548c\u80bf\u7624\u3002\u57fa\u4e8e2010\u5e74\u524d\u540eNGS\u6d4b\u5e8f\u5e73\u53f0\u4e0a\u53d1\u5c55\u8d77\u6765\u7684\u5355\u7ec6\u80de\u6280\u672f\uff0c\u8fdb\u5165\u4e34\u5e8a\u5e7f\u6cdb\u5e94\u7528\u7684\u6807\u5fd7\u6027\u4e8b\u4ef6\u662f\uff0c\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u6280\u672f\u5e94\u7528\u8f85\u52a9\u751f\u6b96PGS\/PGD\u83b7\u5f97NMPA\u6279\u51c6\u3002<\/div>\n<div>2020\u5e742\u6708\uff0c\u751f\u6b96\u5065\u5eb7\u9886\u57df\u7684\u8d1d\u5eb7\u533b\u7597\u7684PGT-A\u8bd5\u5242\u76d2\u83b7\u5f97NMPA\u7684\u6279\u51c6\u8fdb\u5165\u4e34\u5e8a\u68c0\u6d4b\u3002\u5b83\u5229\u7528\u80da\u80ce\u56ca\u80da\u671f\u7ec6\u80de\u8fdb\u884c\u690d\u5165\u524d\u67d3\u8272\u4f53\u5f02\u5e38\u68c0\u6d4b\u65b9\u6cd5\uff0c\u6839\u636e\u8d1d\u5eb7\u533b\u7597\u62a5\u9053\uff1a\u91c7\u7528\u4e86\u201c\u5168\u65b0\u7684\u5355\u7ec6\u80de\u5efa\u5e93\u65b9\u6cd5BaseMTLP\uff0c\u53ef\u5c06\u5355\u7ec6\u80de\u6269\u589e\u65b9\u6cd5\u548c\u6d4b\u5e8f\u524d\u5904\u7406\u878d\u4e3a\u4e00\u6b65\u64cd\u4f5c\uff0c\u6574\u4e2a\u68c0\u6d4b\u8fc7\u7a0b\u63a7\u5236\u57288\u5c0f\u65f6\u5185\u201d\u3002\u201c\u4e00\u6b21\u6027\u5bf9\u80da\u80ce\u8fdb\u884c\u4f4e\u6df1\u5ea6\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\uff0c\u5e76\u5229\u7528\u7279\u5b9a\u7b97\u6cd5\u5bf9\u53d7\u68c0\u80da\u80ce\u768423\u5bf9\u67d3\u8272\u4f53\u975e\u6574\u500d\u6027\u53ca\u4e00\u5b9a\u5927\u5c0f\u7684\u7247\u6bb5\u7f3a\u5931\u91cd\u590d\u8fdb\u884c\u7b5b\u67e5\u201d\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBiaYibRTibib1X4zdUiaOYboZpWicc9P5ql7QjQGnHiatKUthGCrP89cv35oMPvvxicyzU1Zocv5icgwmEgyg.png\" alt=\"RmFicvQBAkgBiaYibRTibib1X4zdUiaOYboZpWicc9P5ql7QjQGnHiatKUthGCrP89cv35oMPvvxicyzU1Zocv5icgwmEgyg\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe6\uff1a\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u7684\u5f00\u521b\u8005Nicholas Navin\uff08\u6765\u6e90\/MD Anderson Cancer Center\uff09<\/div>\n<div>\u53e6\u4e00\u65b9\u9762\uff0c\u5728\u80bf\u7624\u9886\u57df\uff0c\u5355\u7ec6\u80deDNA \u57fa\u56e0\u7ec4\u6d4b\u5e8f\u7684\u5f00\u521b\u8005\u2014\u2014\u6765\u81ea\u7f8e\u56fd\u5fb7\u514b\u8428\u65af\u5927\u5b66MD Anderson\u764c\u75c7\u4e2d\u5fc3Nicholas Navin\uff0c\u65e9\u57282011\u5e74\u7ed8\u5236\u51fa\u80bf\u7624\u5185\u7ec6\u80de\u591a\u6837\u6027\u53ca\u5176\u76f8\u4e92\u4f5c\u7528\u65b9\u5f0f\u7684\u56fe\u8c31\u3002Nicholas Navin\u8ba4\u4e3a\uff1a\u201c\u5355\u7ec6\u80de\u6d4b\u5e8f\u662f\u4e00\u9879\u975e\u5e38\u5f3a\u5927\u7684\u6280\u672f\uff0c\u53ef\u4ee5\u5e2e\u52a9\u4eba\u4eec\u53d1\u73b0\u80bf\u7624\u7ec6\u80de\u91cc\u7684\u57fa\u56e0\u7ec4\u53d8\u5f02\u3002\u201d<\/div>\n<div>\u56fd\u5185\uff0c\u4ee5\u6d5a\u60e0\u751f\u7269\u4e3a\u4ee3\u8868\uff0c\u5f00\u53d1\u7684\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u6280\u672f\u5e73\u53f0\u83b7\u5f97NMPA\u7b2c\u4e8c\u7c7b\u533b\u7597\u5668\u68b0\u4ea7\u54c1\u6ce8\u518c\u8bc1\uff0c\u6b63\u63a8\u8fdb\u76f8\u5173\u5355\u7ec6\u80de\u8bca\u65ad\u8bd5\u5242\u76d2\u7684\u7814\u53d1\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBiaYibRTibib1X4zdUiaOYboZpW1MTY8MtjjJmlUoPrMNsmCcazsicsuXDSyNN7ibINq1kmhKHoQ6IQcowg.jpeg\" alt=\"RmFicvQBAkgBiaYibRTibib1X4zdUiaOYboZpW1MTY8MtjjJmlUoPrMNsmCcazsicsuXDSyNN7ibINq1kmhKHoQ6IQcowg\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe7\uff1a\u6db2\u4f53\u6d3b\u68c0\u4e4b\u7236Klaus Pantel<\/div>\n<div>2019\u5e748\u6708Nature Review Cancer\u7684\u4e00\u7bc7\u7efc\u8ff0\u4e2d\uff0c\u6db2\u4f53\u6d3b\u68c0\u4e4b\u7236Klaus Pantel\u63d0\u5230\uff1aSingle-cell technologies have contributed to unravelling tumour heterogeneity, now considered a hallmark of cancer and one of the main causes of tumour resistance to cancer therapies. \u201c\u5355\u7ec6\u80de\u6280\u672f\u5df2\u7ecf\u5927\u5927\u52a9\u529b\u63ed\u793a\u80bf\u7624\u7684\u5f02\u8d28\u6027\uff0c\u5f02\u8d28\u6027\u5df2\u7ecf\u88ab\u89c6\u4e3a\u764c\u75c7\u7684\u4e00\u4e2a\u6839\u672c\u7684\u6807\u5fd7\uff0c\u4e5f\u662f\u80bf\u7624\u5bf9\u764c\u75c7\u7597\u6cd5\u4ea7\u751f\u6297\u836f\u6027\u7684\u4e3b\u8981\u539f\u56e0\u4e4b\u4e00\u201d\u3002<\/div>\n<div>\u80bf\u7624\u5355\u7ec6\u80de\u57fa\u56e0\u5f02\u8d28\u6027\u7684\u4e34\u5e8a\u5e94\u7528\u4e9f\u9700\u9ad8\u8d28\u91cf\u7684\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\uff0c\u6765\u533a\u5206\u80bf\u7624\u5355\u7ec6\u80deSNV\u6216CNA\u4e4b\u95f4\u7684\u5dee\u5f02\uff0c\u7528\u4e8e\u66f4\u52a0\u7cbe\u51c6\u7684\u80bf\u7624\u8bca\u65ad\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBiaYibRTibib1X4zdUiaOYboZpWN6IhbQbyESQmwybDq2lh3DVNKFurbrJe08amDQZllxYqzibyDarOICA.png\" alt=\"RmFicvQBAkgBiaYibRTibib1X4zdUiaOYboZpWN6IhbQbyESQmwybDq2lh3DVNKFurbrJe08amDQZllxYqzibyDarOICA\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe8\uff1a\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u6280\u672f\u4ea7\u4e1a\u56fe\u8c31\uff08\u6765\u6e90\/\u57fa\u56e0\u6167\u6574\u7406\uff09<\/div>\n<div>\u76ee\u524d\uff0c\u56fd\u5185\u5916\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u6280\u672f\u4e34\u5e8a\u4ea7\u54c1\u5316\u98de\u901f\u53d1\u5c55\uff0c\u867d\u7136\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u6280\u672f\u8fd8\u6ca1\u8fbe\u5230\u4ea7\u4e1a\u6216\u884c\u4e1a\u7684\u89c4\u6a21\uff0c\u4f46\u5df2\u521d\u5177\u5b8c\u6574\u4ea7\u4e1a\u94fe\uff0c\u5305\u62ec\u4e0a\u6e38\u7684\u5355\u7ec6\u80de\u5206\u9009\u5efa\u5e93\u4e0e\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u3001\u4e2d\u6e38\u7684\u5355\u7ec6\u80deDNA\u751f\u7269\u4fe1\u606f\u5206\u6790\u4ee5\u53ca\u4e0b\u6e38\u7684\u5e94\u7528\u5f00\u53d1\uff08\u4ea7\u4e1a\u56fe\u8c31\u89c1\u56fe8\uff09\u3002\u5176\u4e2d\uff0c\u63d0\u4f9b\u7aef\u5bf9\u7aef\u6574\u4f53\u89e3\u51b3\u65b9\u6848\u7684\u4f01\u4e1a\u8f83\u5c11\uff0c\u56fd\u5185\u4f01\u4e1a\u66f4\u52a0\u7a00\u5c11\uff0c\u5177\u6709\u4ee3\u8868\u6027\u7684\u4f01\u4e1a\u5305\u62ec\u6d5a\u60e0\u751f\u7269\u7b49\u3002<\/div>\n<div>\u56db\u3001\u63d0\u4f9b\u4e34\u5e8a\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u7aef\u5bf9\u7aef\u89e3\u51b3\u65b9\u6848\u2014\u2014\u6d5a\u60e0\u751f\u7269<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBiaYibRTibib1X4zdUiaOYboZpWD4fTLeCichp6fNe5VS6ycJWsUQ45Ab1gqiaEMwpuFUmAL5mYQmsFpiaPw.jpeg\" alt=\"RmFicvQBAkgBiaYibRTibib1X4zdUiaOYboZpWD4fTLeCichp6fNe5VS6ycJWsUQ45Ab1gqiaEMwpuFUmAL5mYQmsFpiaPw\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe9\uff1a\u6d5a\u60e0\u751f\u7269\u960e\u707c\u8f89\u5728\u514b\u5229\u592b\u5170<\/div>\n<div style=\"text-align: center;\">\u5168\u7403\u533b\u5b66\u521b\u65b0\u5cf0\u4f1a\u4e0a\u4f5c\u5355\u7ec6\u80de\u6d4b\u5e8f\u62a5\u544a<\/div>\n<div>\u4f5c\u4e3a\u5168\u7403\u9996\u6279\u3001\u56fd\u5185\u9996\u4e2a\u5e94\u7528\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u6280\u672f\uff0c\u5e76\u5f00\u59cb\u8fdb\u5165\u4e34\u5e8a\u7684\u80bf\u7624\u5355\u7ec6\u80de\u8bca\u65ad\u516c\u53f8\uff0c\u6d5a\u60e0\u751f\u7269\u62e5\u6709\u9886\u5148\u7684\u786c\u6838\u6280\u672f\u548c\u4e30\u5bcc\u7684\u4ea7\u54c1\u7ebf\u30022019\u5e7410\u6708\uff0c\u6d5a\u60e0\u751f\u7269\u53d7\u9080\u53c2\u52a0\u514b\u5229\u592b\u5170\u8bca\u6240\u4e3e\u529e\u7684\u5168\u7403\u533b\u5b66\u521b\u65b0\u5cf0\u4f1a\uff0c\u5e76\u4f5c\u4e3a\u4e2d\u56fd\u552f\u4e00\u4e00\u5bb6\u4f01\u4e1a\u4e0a\u53f0\u5206\u4eab\uff0c\u5e76\u4e0e\u514b\u5229\u592b\u5170\u8bca\u6240\u8fbe\u6210\u4e86\u4e34\u5e8a\u8f6c\u5316\u5408\u4f5c\u610f\u5411\u3002\u4f17\u6240\u5468\u77e5\uff0c\u514b\u5229\u592b\u5170\u8bca\u6240\u7684\u6ccc\u5c3f\u5916\u79d1\u8fde\u7eed\u591a\u5e74\u6392\u540d\u7f8e\u56fd\u7b2c\u4e00\u3002<\/div>\n<div>\u6d5a\u60e0\u751f\u7269\u521b\u59cb\u4eba\u517cCEO\u960e\u707c\u8f89\u5728\u4f1a\u4e0a\u63d0\u5230\uff1a\u201c\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u66f4\u8d34\u8fd1\u4e34\u5e8a\uff0c\u7279\u522b\u662f\u80bf\u7624\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u5c06\u8fdb\u5165\u65b0\u7684\u5feb\u901f\u53d1\u5c55\u9636\u6bb5\u3002\u201d\u83b7\u5f97\u4e0e\u4f1a\u4e13\u5bb6\u7684\u8ba4\u53ef\u3002<\/div>\n<div>1\uff09\u6280\u672f\u7814\u53d1\u7684\u7a81\u7834<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBiaYibRTibib1X4zdUiaOYboZpWFRibayH4W1YA78Mo1t0TbCKEmd8l77Hvymn0Q8n7vhroTwicKic8M6Q0Q.png\" alt=\"RmFicvQBAkgBiaYibRTibib1X4zdUiaOYboZpWFRibayH4W1YA78Mo1t0TbCKEmd8l77Hvymn0Q8n7vhroTwicKic8M6Q0Q\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe10\uff1a\u65bd\u5947\u60e0\u7814\u7a76\u5458\u5728PNAS\u53d1\u8868\u7684\u7814\u7a76\u6210\u679c<\/div>\n<div>\u80bf\u7624\u7ec6\u80de\u7f3a\u4e4f\u6709\u6548\u7684\u6807\u5fd7\u7269\u3001\u5206\u79bb\u5bcc\u96c6\u7a00\u6709\u5355\u7ec6\u80de\u96be\u5ea6\u5927\u3001\u7a00\u6709\u5355\u7ec6\u80de\u4e0e\u764c\u75c7\u53d1\u751f\u3001\u8f6c\u79fb\u5173\u7cfb\u4e0d\u660e\u786e\u7b49\u95ee\u9898\uff0c\u662f\u7a00\u6709\u80bf\u7624\u5355\u7ec6\u80de\u9886\u57df\u4e00\u76f4\u4ee5\u6765\u9762\u4e34\u7684\u6bd4\u8f83\u5927\u7684\u74f6\u9888\u95ee\u9898\u3002\u00a0<\/div>\n<div>2017\u5e74\uff0c\u590d\u65e6\u5927\u5b66\u751f\u7269\u533b\u5b66\u7814\u7a76\u9662\u7814\u7a76\u5458\u3001\u6d5a\u60e0\u751f\u7269\u516c\u53f8\u7684\u79d1\u5b66\u987e\u95ee\u65bd\u5947\u60e0\u6559\u6388\uff0c\u5728PNAS\uff08\u7f8e\u56fd\u79d1\u5b66\u9662\u9662\u520a\uff09\u4e0a\u53d1\u6587\uff08\u88ab\u5168\u7403\u6743\u5a01\u4e13\u5bb6Richard Light\u63a8\u8350\u4e3aF1000\u4f18\u79c0\u8bba\u6587\uff0c\u5165\u9009\u7387\u4f4e\u4e8e2\u2030\uff09\uff0c\u63d0\u51fa\u548cPET-CT\u76f8\u540c\u68c0\u6d4b\u539f\u7406\u7684\u8461\u8404\u7cd6\u4ee3\u8c22\u6807\u5fd7\u7269\u53ef\u4ee5\u5f88\u597d\u7684\u9274\u522b\u51fa\u7a00\u6709\u80bf\u7624\u5355\u7ec6\u80de\uff0c\u7a81\u7834\u4e86\u539f\u672c\u6db2\u4f53\u6d3b\u68c0\u4e2d\u3001\u7a00\u6709\u80bf\u7624\u7ec6\u80de\u68c0\u6d4b\u7f3a\u4e4f\u9ad8\u7279\u5f02\u6027\u6807\u5fd7\u7269\u7684\u74f6\u9888\u3002<\/div>\n<div>\u57fa\u4e8eWarburg\u6548\u5e94\uff08\u6709\u6c27\u6761\u4ef6\u4e0b\u764c\u7ec6\u80de\u503e\u5411\u4e8e\u5c06\u8461\u8404\u7cd6\u4ee3\u8c22\u4e3a\u4e73\u9178\uff0c\u4e5f\u79f0\u6709\u6c27\u7cd6\u9175\u89e3\uff09\u548c\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u6280\u672f\uff0c\u8fd9\u4e00\u53d1\u73b0\u5728\u5168\u7403\u5f00\u521b\u4e86\u4f53\u6db2\u6837\u672c\u9274\u522b\u80bf\u7624\u5355\u7ec6\u80de\u7684\u4e00\u79cd\u7a81\u7834\u6027\u521b\u65b0\u6280\u672f\u3002<\/div>\n<div>\u65bd\u5947\u60e0\u6559\u6388\uff1a\u201c\u4f53\u6db2\uff08\u5c3f\u6db2\u3001\u80f8\u8179\u6c34\u3001\u8111\u810a\u6db2\u3001\u8840\u6db2\u7b49\uff09\u4e2d\u7684\u7a00\u6709\u80bf\u7624\u7ec6\u80de\u53ef\u53cd\u6620\u80bf\u7624\u539f\u53d1\u6216\u8f6c\u79fb\u75c5\u7076\u7684\u5206\u5b50\u4fe1\u606f\uff0c\u540c\u65f6\u4e5f\u662f\u80bf\u7624\u6216\u80bf\u7624\u8f6c\u79fb\u5b58\u5728\u7684\u9ad8\u7ea7\u522b\u3001\u53ef\u89c6\u7684\u8bc1\u636e\u3002\u7ed3\u5408\u7279\u5f02\u6027\u7684\u86cb\u767d\u6807\u5fd7\u7269\u548c\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u6280\u672f\uff0c\u53ef\u4ee5\u4e3a\u4e34\u5e8a\u8bca\u65ad\u63d0\u4f9b\u65e0\uff08\u4f4e\uff09\u521b\u3001\u9ad8\u7075\u654f\u7684\u8bca\u65ad\u5de5\u5177\u201d\u3002<\/div>\n<div>2\uff09\u4ea7\u54c1\u62a5\u8bc1\uff1a\u9996\u4e2a\u5355\u7ec6\u80de\u56fe\u50cf\u5206\u6790\u81ea\u52a8\u5206\u79bb\u4eea\u83b7\u5f97II\u7c7b\u6ce8\u518c\u8bc1<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBiaYibRTibib1X4zdUiaOYboZpW5FTiaH2HUQNk6icRwMxlNB1M8Rnzl1UYIdukp1KcDn21XSicXDicc6VItg.png\" alt=\"RmFicvQBAkgBiaYibRTibib1X4zdUiaOYboZpW5FTiaH2HUQNk6icRwMxlNB1M8Rnzl1UYIdukp1KcDn21XSicXDicc6VItg\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe11\uff1a\u5355\u7ec6\u80de\u56fe\u50cf\u5206\u6790\u81ea\u52a8\u5206\u79bb\u4eea<\/div>\n<div>\u4ee5\u4e0a\u7814\u7a76\u548c\u591a\u9879\u4e13\u5229\u6210\u4e3a\u6d5a\u60e0\u751f\u7269\u7684\u6280\u672f\u57fa\u7840\uff0c\u4f7f\u5176\u5728\u5355\u7ec6\u80de\u68c0\u6d4b\u4e0a\u8d70\u5728\u4e86\u4e34\u5e8a\u5e94\u7528\u8f6c\u5316\u7684\u524d\u5217\uff0c\u7814\u53d1\u51fa\u4e86\u5355\u7ec6\u80de\u81ea\u52a8\u5206\u6790\u4eea\u5668\u3001\u548c\u68c0\u6d4b\u8bd5\u5242\u3002\u4eca\u5e745\u670821\u65e5\uff0c\u6d5a\u60e0\u751f\u7269\u201c\u5355\u7ec6\u80de\u56fe\u50cf\u5206\u6790\u81ea\u52a8\u5206\u79bb\u4eeaseq-PET\u5e73\u53f0\u201d\u6b63\u5f0f\u53d6\u5f97NMPA\u7b2c\u4e8c\u7c7b\u533b\u7597\u5668\u68b0\u4ea7\u54c1\u6ce8\u518c\u8bc1\u3002\u00a0<\/div>\n<div>\u8fd9\u662f\u76ee\u524d\u4e3a\u6b62\u56fd\u5185\u5916\u6279\u51c6\u7684\u7b2c\u4e00\u6b3e\u4e34\u5e8a\u7ea7\u5e94\u7528\u7684\u5355\u7ec6\u80de\u68c0\u6d4b\u4eea\u5668\uff0c\u6807\u5fd7\u7740\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u5f00\u59cb\u8fc8\u8fdb\u80bf\u7624\u4e34\u5e8a\u5e02\u573a\u2014\u2014\u80bf\u7624\u5355\u7ec6\u80de\u8bca\u65adSTC \uff08Single Tumor Cell Dx\uff09\u3002<\/div>\n<div>\u00a0<\/div>\n<div>3\uff09\u56db\u5927\u5e94\u7528\u573a\u666f\u84c4\u52bf\u5f85\u53d1<\/div>\n<div>\u672c\u6b21\u83b7\u6279\u7684\u5355\u7ec6\u80de\u8bca\u65adseq-PET\u5e73\u53f0\uff0c\u662f\u6d5a\u60e0\u751f\u7269\u5f00\u5c55\u4e34\u5e8a\u5e94\u7528\u5de5\u4f5c\u7684\u57fa\u7840\uff0c\u6839\u636e\u5c3f\u6db2\u3001\u4f53\u6db2\u3001\u8840\u6db2\u548c\u5bab\u9888\u7c98\u6db2\u56db\u7c7b\u4e0d\u540c\u7684\u6837\u672c\uff0c\u5df2\u7ecf\u5f62\u6210\u4e86\u8be5\u5e73\u53f0\u7684\u56db\u5927\u8f85\u52a9\u8bca\u65ad\u5e94\u7528\u573a\u666f\uff1a<\/div>\n<div>\u00b7\u00a0\u5c3f\u6db2\u65e0\u521b\u68c0\u6d4b\u8180\u80f1\u764c\u7684\u4ea7\u54c1\u5df2\u83b7NMPA\u8ba4\u8bc1\uff0c\u5728\u89e3\u51b3\u8180\u80f1\u764c\u3001\u80be\u76c2\u80be\u764c\u3001\u8f93\u5c3f\u7ba1\u764c\u7b49\u7591\u96be\u75c5\u4f8b\u7684\u8bca\u65ad\u4e2d\u6df1\u53d7\u4e34\u5e8a\u533b\u751f\u7684\u6b22\u8fce\uff0c\u5e76\u5c06\u8fdb\u4e00\u6b65\u7a81\u7834\u8180\u80f1\u764c\u65e0\u521b\u7b5b\u67e5\u7684\u96be\u9898\uff0c\u4e3a\u5168\u7403\u8180\u80f1\u764c\u7684\u65e9\u8bca\u3001\u65e9\u6cbb\u63d0\u4f9b\u201c\u4e2d\u56fd\u65b9\u6848\u201d\uff0c\u4ea7\u54c1\u76ee\u524d\u5df2\u8fdb\u5165\u533b\u9662\u9500\u552e\uff1b\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>\u00a0\u00b7\u00a0\u4f53\u6db2\u591a\u764c\u79cd\u68c0\u6d4b\u7684\u8bd5\u5242\u76d2\u5df2\u5b8c\u6210NMPA\u7684\u8ba4\u8bc1\uff0c\u4e3b\u8981\u9488\u5bf9\u80f8\u6c34\u3001\u8179\u6c34\u3001\u8111\u810a\u6db2\u7b49\u6837\u672c\uff0c\u8986\u76d6\u80ba\u764c\u3001\u4e73\u817a\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u6dcb\u5df4\u764c\u7b49\u591a\u764c\u79cd\u7684\u68c0\u6d4b\uff0c\u6709\u6548\u5730\u63d0\u5347\u75c5\u7406\u533b\u751f\u5bf9\u4f53\u6db2\u6837\u672c\u80bf\u7624\u7ec6\u80de\u9274\u522b\u7684\u7075\u654f\u5ea6\uff1b\u00a0<\/div>\n<div>\u00a0\u00b7\u00a0\u6d5a\u60e0\u7684\u521b\u65b0\u6807\u5fd7\u7269\u548c\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u7684\u4e34\u5e8a\u5e94\u7528\uff0c\u5c06\u63a8\u52a8CTC\u68c0\u6d4b\u8fdb\u5165\u201c\u8f6c\u79fb\u65e9\u8bca\u201d\u7684\u9636\u6bb5\uff0c\u51cf\u5c1190%\u56e0\u80bf\u7624\u8f6c\u79fb\u5bfc\u81f4\u7684\u6b7b\u4ea1\uff1b\u00a0<\/div>\n<div>\u00a0\u00b7\u00a0\u4ece\u5973\u6027\u5bab\u9888\u7c98\u6db2\u4e2d\u6355\u83b7\u5230\u80ce\u513f\u5355\u7ec6\u80de\uff0c\u8fdb\u884c\u57fa\u4e8e\u5355\u7ec6\u80de\u7684\u65e0\u521b\u4ea7\u524d\u7b5b\u67e5\uff08Cell-based NIPT\uff09,\u672a\u6765\u4e34\u5e8a\u4ef7\u503c\u53ef\u671f\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u4f18\u79c0\u7684\u4ea7\u54c1\u80cc\u540e\u662f\u4e00\u652f\u201c\u56fd\u9645\u89c6\u91ce+\u524d\u6cbf\u6280\u672f+\u63a5\u5730\u6c14\u4f01\u4e1a\u5bb6+\u4ea7\u4e1a\u94fe\u8d44\u6e90\u201d\u7684\u7814\u53d1\u548c\u7ba1\u7406\u56e2\u961f\uff0c\u56e2\u961f\u6210\u5458\u6765\u81ea\u4ea7\u4e1a\u591a\u4e2a\u9886\u57df\uff0c\u5f7c\u6b64\u4f18\u52bf\u4e92\u8865\u3002\u00a0\u6d5a\u60e0\u751f\u7269\u521b\u59cb\u4eba\u960e\u707c\u8f89\u62e5\u670920\u5e74\u7684\u8de8\u56fd\u4f01\u4e1a\u8fd0\u8425\u7ecf\u9a8c\u53ca\u5e7f\u9614\u7684\u56fd\u9645\u89c6\u91ce\uff1b\u65bd\u5947\u60e0\u6559\u6388\u638c\u63e1\u6700\u524d\u6cbf\u7684\u5355\u7ec6\u80de\u591a\u7ec4\u5b66\u6280\u672f\uff1b\u674e\u964d\u9f99\u670920\u4f59\u5e74IVD\u4f01\u4e1a\u7ba1\u7406\u7ecf\u9a8c\uff0c\u4e13\u6ce8\u52a0\u901fIVD\u4ea7\u54c1\u7684\u4ea7\u4e1a\u5316\uff1b\u8303\u5fd7\u5f3a\u62e5\u6709\u4e30\u5bcc\u7684\u533b\u7597\u8d44\u6e90\u6574\u5408\u548c\u6295\u8d44\u5b75\u5316\u7ecf\u9a8c\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u6d5a\u60e0\u751f\u7269\u521b\u59cb\u4eba\u517cCEO\u960e\u707c\u8f89\u8bf4\uff1a\u201c\u672a\u676510\u5e74\uff0c\u5355\u7ec6\u80de\u6d4b\u5e8f\u5c06\u6210\u4e3a\u4e34\u5e8a\u5e38\u89c4\u68c0\u6d4b\u9879\u76ee\u7684\u4e00\u90e8\u5206\uff0c\u6d5a\u60e0\u751f\u7269\u5bf9Nature 2017\u5e74\u7684\u9884\u6d4b\u6df1\u4fe1\u4e0d\u7591\uff0c\u5e76\u5c06\u4e0d\u65ad\u63a2\u7d22\u548c\u521b\u9020\u672a\u6765\u201d \u3002\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>\u5355\u7ec6\u80de\u6d4b\u5e8f\u6280\u672f\u7684\u7a81\u7834\u548c\u4ea7\u4e1a\u5316\u524d\u666f\u83b7\u5f97\u4e1a\u754c\u4e00\u76f4\u8ba4\u53ef\uff0c\u9664\u4e86\u79d1\u7814\u9886\u57df\u7684\u9ad8\u901a\u91cf\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff0c\u66f4\u5927\u7684\u5e02\u573a\u524d\u666f\u662f\u76ee\u524d\u6b63\u5728\u9010\u6b65\u5e94\u7528\u4e34\u5e8a\u7684\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u3002PGS\/PGD\u662f\u7b2c\u4e00\u4e2a\u5df2\u8fdb\u5165\u4e34\u5e8a\u751f\u6b96\u9886\u57df\u7684\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u4ea7\u54c1\uff1b\u7b2c\u4e8c\u4e2a\u5e94\u7528\u5c06\u662f\u80bf\u7624\u5355\u7ec6\u80deDNA\u8bca\u65ad\u3002\u4ee5\u6d5a\u60e0\u751f\u7269\u4e3a\u4ee3\u8868\u7684\u56fd\u5185\u521b\u65b0\u4f01\u4e1a\uff0c\u6b63\u662f\u4ece\u5355\u7ec6\u80deDNA\u4e34\u5e8a\u8bca\u65ad\u7684\u5165\u53e3\uff0c\u4e0e\u56fd\u9645\u7684\u540c\u884c\u9f50\u5934\u5e76\u8fdb\uff0c\u5f00\u542f\u80bf\u7624\u5355\u7ec6\u80de\u8bca\u65adSTC \uff08Single Tumor Cell Dx\uff09 \u7684\u65b0\u5f81\u7a0b\u3002\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>\u671f\u5f85\u5e76\u76f8\u4fe1\u4e2d\u56fd\u751f\u547d\u5065\u5eb7\u9886\u57df\u7684\u5355\u7ec6\u80de\u6280\u672f\u521b\u65b0\u516c\u53f8\u4e58\u98ce\u7834\u6d6a\uff0c\u5c06\u5355\u7ec6\u80deDNA\u6d4b\u5e8f\u6280\u672f\u5e94\u7528\u4e8e\u4e34\u5e8a\uff0c\u5b9e\u73b0\u5355\u7ec6\u80de\u8bca\u65ad\uff0c\u8ba9\u201c\u4e2d\u56fd\u65b9\u6848\u201d\u4e3a\u5168\u7403\u60a3\u8005\u63d0\u4f9b\u66f4\u65e9\u3001\u66f4\u7cbe\u51c6\u7684\u8bca\u65ad\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u53c2\u8003\u8d44\u6599\uff1a<\/div>\n<div>1. Jie He et al., Cancer incidence and mortality in China, 2014\uff0cChin J Cancer Res(2018)\u00a0<\/div>\n<div>2. Rebecca L. Siegel MPH et al., Cancer statistics, CA(2020)\u00a0<\/div>\n<div>3. https:\/\/www.nature.com\/articles\/s41568-019-0180-2<\/div>\n<div>4.https:\/\/doi.org\/10.1186\/gm247<\/div>\n<div>5. https:\/\/www.cd-genomics.com\/single-cell-dna-sequencing.html\u00a0<\/div>\n<div>6. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3219072\/\u00a0<\/div>\n<div>7. https:\/\/www.cancer.gov\/about-nci\/organization\/ccg\/blog\/2018\/interview-scdna-seq\u00a0<\/div>\n<div>8. https:\/\/www.uib.no\/node\/71466\/110907\/klaus-pantel\u00a0<\/div>\n<div>9. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4441954\/\u00a0<\/div>\n<div>10. https:\/\/www.cancer.gov\/about-nci\/organization\/ccg\/blog\/2018\/interview-scdna-seq\u00a0<\/div>\n<div>11. https:\/\/www.pnas.org\/content\/114\/10\/2544<\/div>\n<div>\u00a0<\/div>\n<div>\u63a8\u8350\u9605\u8bfb<\/div>\n<div><a 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