{"id":9035,"date":"2020-09-15T12:00:36","date_gmt":"2020-09-15T04:00:36","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&mid=100016066&idx=1&sn=d701f281e775b5309a6243e7360942b2&chksm=6b714d755c06c463351701a67ad68660b1475d71a6942740189e08bd0e5183be2ea665d6b055#rd"},"modified":"2026-04-08T09:43:18","modified_gmt":"2026-04-08T01:43:18","slug":"539956","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2020\/09\/15\/539956\/","title":{"rendered":"\u65b0\u51a0\u80ba\u708e\u7684\u76ca\u751f\u83cc\u8f85\u52a9\u7597\u6cd5\u65b0\u6210\u679c | \u540c\u6d4e\u5341\u9662\u548c\u4e0a\u6d77\u516c\u536b\u4e34\u5e8a\u4e2d\u5fc3\u8054\u5408\u53d1\u5e03"},"content":{"rendered":"

<\/p>\n

\u3010\u5bfc\u8bed\u3011\u8fd1\u65e5\uff0c\u540c\u6d4e\u5927\u5b66\u9644\u5c5e\u7b2c\u5341\u4eba\u6c11\u533b\u9662\u79e6\u73af\u9f99\u6559\u6388\u3001\u79e6\u6960\u6559\u6388\u548c\u4e0a\u6d77\u5e02\u516c\u5171\u536b\u751f\u4e34\u5e8a\u4e2d\u5fc3\u5362\u6d2a\u5dde\u6559\u6388\u4e0e\u56e2\u961f\u5728Springer Nature\u4e3b\u529e\u7684Research Square\u5e73\u53f0\u4ee5\u9884\u5370\u8bba\u6587\u7684\u5f62\u5f0f\u516c\u5e03\u4e86\u6b63\u5728Microbiome\u6742\u5fd7\u5ba1\u7a3f\u7684\u7814\u7a76\u201cThe Volatile and Heterogenous Gut Microbiota Shifts of COVID-19 Patients Over The Course of A Probiotics-Assisted Therapy\u201d\uff0c\u62a5\u9053\u4e86\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u5728\u76ca\u751f\u83cc\u8f85\u52a9\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u80a0\u9053\u5fae\u751f\u7269\u7684\u53d8\u5316\u3002<\/div>\n
\u7f16\u8f91 | Shawne \u5173\u952e\u8bcd |\u00a0\u65b0\u51a0\u80ba\u708e\u00a0\u76ca\u751f\u83cc \u7814\u7a76<\/div>\n\n
\n
\"RmFicvQBAkgBgUk1nGpav8euReLpruj7f0PfJzib7hT3giafYX4zFe13ug9p0yyrm4onOsEP1vib85XsJ4ib8TRg1eA\"\/<\/figure><\/div>\n\n
\u56fe\u6e90\/In\u00a0Review<\/div>\n
\u76ee\u524d\u65b0\u51a0\u80ba\u708e\u8fd8\u6ca1\u6709\u660e\u786e\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u800c\u5168\u4e16\u754c\u7684\u75ab\u82d7\u63a5\u79cd\u53ef\u80fd\u4e5f\u9700\u8981\u6570\u5e74\u65f6\u95f4\u624d\u80fd\u5b8c\u6210\u3002\u9274\u4e8e\u60a3\u8005\u53ef\u80fd\u8868\u73b0\u51fa\u4e25\u91cd\u7684\u80c3\u80a0\u9053\u75c7\u72b6\u548c\u5fae\u751f\u7269\u5f02\u5e38\uff0c\u5c06\u76ca\u751f\u83cc\u7eb3\u5165\u53ef\u80fd\u4f1a\u6539\u5584\u5176\u6cbb\u7597\u6548\u679c\u3002<\/div>\n
\u8fd1\u65e5\uff0c\u540c\u6d4e\u5927\u5b66\u9644\u5c5e\u7b2c\u5341\u4eba\u6c11\u533b\u9662\u79e6\u73af\u9f99\u6559\u6388\u3001\u79e6\u6960\u6559\u6388\u548c\u4e0a\u6d77\u5e02\u516c\u5171\u536b\u751f\u4e34\u5e8a\u4e2d\u5fc3\u5362\u6d2a\u5dde\u6559\u6388\u56e2\u961f\u91c7\u7528\u76ca\u751f\u83cc\u8f85\u52a9\u7597\u6cd5\u5bf9\u4e00\u7ec4\u65b0\u51a0\u80ba\u708e\u91cd\u75c7\u60a3\u8005\u8fdb\u884c\u6cbb\u7597\uff0c\u5e76\u901a\u8fc716S rRNA\u57fa\u56e0\u6d4b\u5e8f\u548c\u5b8f\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\u6280\u672f\u76d1\u6d4b\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u548c\u4e34\u5e8a\u8868\u73b0\u7684\u52a8\u6001\u3002<\/div>\n
\u00a0<\/div>\n
\u8be5\u9879\u7814\u7a76\u6210\u679c\u201cThe Volatile and Heterogenous Gut Microbiota Shifts of COVID-19 Patients Over The Course of A Probiotics-Assisted Therapy\u201d\u6b63\u5728Microbiome\u6742\u5fd7\u5ba1\u7a3f\u4e2d\uff0c\u540c\u65f6\u5728Springer Nature\u4e3b\u529e\u7684Research Square\u5e73\u53f0\u4ee5\u9884\u5370\u8bba\u6587\u7684\u5f62\u5f0f\u516c\u5e03\u3002<\/div>\n
\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u8868\u73b0\u51fa\u663e\u8457\u7684\u80a0\u9053\u5fae\u751f\u7269\u7d0a\u4e71\uff0c\u5176\u7279\u70b9\u662f\u5fae\u751f\u7269\u591a\u6837\u6027\u51cf\u5c11\uff0c\u5fae\u751f\u7269\u79cd\u7c7b\u3001\u529f\u80fd\u548c\u8f6c\u5f55\u6d3b\u6027\u90fd\u53d1\u751f\u4e86\u5de8\u5927\u6539\u53d8\u3002\u91c7\u53d6\u5927\u5242\u91cf\u7684\u76ca\u751f\u83cc\u8f85\u52a9\u6cbb\u7597\uff0c\u75be\u75c5\u75c7\u72b6\u6709\u4e86\u660e\u663e\u6539\u5584\uff0c\u708e\u75c7\u6307\u6807\u964d\u4f4e\u3002\u540c\u65f6\uff0c\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u6210\u4e5f\u6709\u4e86\u660e\u663e\u6062\u590d\u3002<\/div>\n
\u00a0<\/div>\n
\u4e00\u3001\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u80a0\u9053\u83cc\u7fa4\u6781\u5ea6\u7d0a\u4e71<\/div>\n
\u7269\u79cd\u7ec4\u6210\u7684\u6539\u53d8\u4e3b\u8981\u8868\u73b0\u5728\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u80a0\u9053\u4e2d\u80a0\u7403\u83cc\uff08Enterococcus\uff09\u3001\u7ea2\u7403\u83cc\uff08Rhodococcus\uff09\u7684\u76f8\u5bf9\u4e30\u5ea6\u663e\u8457\u589e\u52a0\uff0c\u800c\u6297\u708e\u76f8\u5173\u7684\u7caa\u6746\u83cc(Faecalibacterium)\u3001\u7f57\u65af\u6c0f\u83cc(Roseburia)\u548c\u68ad\u83ccXIVa\uff08Clostridium XlVa\uff09\u7684\u76f8\u5bf9\u4e30\u5ea6\u663e\u8457\u51cf\u5c11\u3002<\/div>\n
\u00a0<\/div>\n
\u901a\u8fc7\u5b8f\u8f6c\u5f55\u7ec4\u6570\u636e\u7684\u5206\u6790\u4e5f\u53d1\u73b0\u4e86\u60a3\u8005\u80a0\u9053\u4e2d\u673a\u4f1a\u81f4\u75c5\u83cc\u7684\u8f6c\u5f55\u6d3b\u6027\u76f8\u5bf9\u63d0\u9ad8\uff0c\u5305\u62ec\u5927\u80a0\u6746\u83cc\uff08Escherichia coli\uff09, \u6c99\u95e8\u6c0f\u83cc\uff08Salmonella enterica\uff09, \u8033\u8461\u8404\u7403\u83cc\uff08Staphylococcus auricularis\uff09 \u548c\u80ba\u708e\u514b\u96f7\u4f2f\u83cc\uff08Klebsiella pneumoniae\uff09\uff0c\u800c\u80a0\u9053\u4e3b\u8981\u5171\u751f\u83cc\u666e\u6c0f\u7caa\u6746\u83cc\uff08Faecalibacterium prausnitzii\uff09\u7684\u8f6c\u5f55\u6d3b\u6027\u5219\u660e\u663e\u964d\u4f4e\u3002\u91cd\u8981\u7684\u662f\u60a3\u8005\u4e2a\u4f53\u95f4\u5f02\u8d28\u6027\u548c\u65f6\u95f4\u70b9\u95f4\u6ce2\u52a8\u5de8\u5927\uff0c\u8868\u73b0\u4e3a\u6700\u4e30\u5bcc\u6216\u8f6c\u5f55\u6d3b\u6027\u6700\u9ad8\u7684\u5fae\u751f\u7269\u5206\u7c7b\u5f80\u5f80\u5728\u60a3\u8005\u4e4b\u95f4\u548c\u6cbb\u7597\u5404\u65f6\u95f4\u70b9\u95f4\u5dee\u522b\u5f88\u5927\u3002\u80a0\u9053\u5fae\u751f\u7269\u7269\u79cd\u548c\u529f\u80fd\u4e0a\u7684\u6539\u53d8\u4e0e\u75be\u75c5\u4e25\u91cd\u7a0b\u5ea6\u76f8\u5173\u3002<\/div>\n\n
\n
\"RmFicvQBAkgBgUk1nGpav8euReLpruj7fQt3c5cn6vTty9Y2bgRkIWr2BptXicaR0Cd5tjUUl00ufO0FLcpZxUFA\"\/<\/figure><\/div>\n\n
\u56fe\uff1a\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u80a0\u9053\u83cc\u7fa4\u6781\u5ea6\u7d0a\u4e71\uff0c\u4e14\u60a3\u8005\u95f4\u5dee\u5f02\u5de8\u5927<\/div>\n
\u6765\u6e90\/\u6587\u7ae0\u4f5c\u8005<\/div>\n
\u4e8c\u3001\u76ca\u751f\u83cc\u8f85\u52a9\u6cbb\u7597\u660e\u663e\u6539\u5584\u65b0\u51a0\u75c7\u72b6\u548c\u80a0\u9053\u5fae\u751f\u7269<\/div>\n
\u7814\u7a76\u91c7\u53d6\u5927\u5242\u91cf\u7684\u76ca\u751f\u83cc\uff082000\u4ebfCFU\/\u5929\uff0c\u4e3b\u8981\u6210\u5206\u5305\u62ecB. lactis subsp. HNO19, L. casei subsp. Lc-11, L. plantarum subsp. Lp-15, B. lactis subsp. B420, B. longum subsp. BL05, L. format subsp. Lg-36, L. rhamnosus subsp. Lr-32, L. paracasei subsp. Lpc-37, and L. salivarius\uff09\u8f85\u52a9\u6cbb\u7597\uff0c\u901a\u8fc714\u5929\u7684\u6cbb\u7597\u540e\uff0c\u75be\u75c5\u75c7\u72b6\u6709\u4e86\u660e\u663e\u6539\u5584\uff0c\u708e\u75c7\u6307\u6807\u964d\u4f4e\uff0c\u5305\u62ec\u8840\u6e05\u80bf\u7624\u574f\u6b7b\u56e0\u5b50-\u03b1\uff08tumor necrosis factor-\u03b1,TNF-\u03b1)\u3001\u767d\u4ecb\u7d20-1\u03b2(interleukin-1\u03b2, IL-1\u03b2)\uff0c\u767d\u4ecb\u7d20-4(interleukin-4, IL-4)\u548c\u767d\u4ecb\u7d20-12P70 (interleukin-12P70, IL-12P70)\u3002<\/div>\n
\u00a0<\/div>\n
\u540c\u65f6\uff0c\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u6210\u4e5f\u6709\u4e86\u660e\u663e\u6062\u590d\uff0c\u5176\u8868\u73b0\u4e3a\u80a0\u7403\u83cc\uff08Enterococcus\uff09\u3001\u7ea2\u7403\u83cc\uff08Rhodococcus\uff09\u7684\u76f8\u5bf9\u4e30\u5ea6\u51cf\u5c11\u4ee5\u53ca\u7caa\u6746\u83cc(Faecalibacterium)\u548c\u7f57\u65af\u6c0f\u83cc(Roseburia)\u4e30\u5ea6\u7684\u589e\u52a0\u3002\u5927\u80a0\u6746\u83cc\uff08Escherichia coli\uff09, \u6c99\u95e8\u6c0f\u83cc\uff08Salmonella enterica\uff09, \u8033\u8461\u8404\u7403\u83cc\uff08Staphylococcus auricularis\uff09 \u548c\u80ba\u708e\u514b\u96f7\u4f2f\u83cc\uff08Klebsiella pneumoniae\uff09\u673a\u4f1a\u81f4\u75c5\u83cc\u7684\u8f6c\u5f55\u6d3b\u6027\u76f8\u5bf9\u964d\u4f4e\uff0c\u800c\u666e\u6c0f\u7caa\u6746\u83cc\uff08Faecalibacterium prausnitzii\uff09\u548c\u4eba\u7f57\u65af\u62dc\u745e\u6c0f\u83cc\uff08Roseburia hominis\uff09\u7b49\u6297\u708e\u76f8\u5173\u83cc\u7684\u8f6c\u5f55\u6d3b\u6027\u5219\u660e\u663e\u63d0\u9ad8\u3002<\/div>\n
\u00a0<\/div>\n
\u7814\u7a76\u8fd8\u53d1\u73b0\u90e8\u5206\u9ad8\u9f84\u6216\u514d\u75ab\u72b6\u6001\u4f4e\u4e0b\u7684\u60a3\u8005\u7684\u83cc\u7fa4\u6062\u590d\u60c5\u51b5\u76f8\u5bf9\u8f83\u5dee\uff0c\u8fd9\u8868\u660e\u4e86\u6cbb\u7597\u7684\u6548\u679c\u53ef\u80fd\u4e0e\u60a3\u8005\u7684\u5e74\u9f84\u548c\u514d\u75ab\u72b6\u6001\u6709\u5173\u3002<\/div>\n
\u8be5\u9879\u7814\u7a76\u9996\u6b21\u62a5\u9053\u4e86\u4f7f\u7528\u76ca\u751f\u83cc\u8f85\u52a9\u7597\u6cd5\u5bf9\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u8fdb\u884c\u6cbb\u7597\uff0c\u7814\u7a76\u8868\u660e\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u7f3a\u4e4f\u80a0\u9053\u5fae\u751f\u6001\u7a33\u5b9a\u6027\uff0c\u9700\u8981\u91c7\u53d6\u63aa\u65bd\u6539\u5584\u60a3\u8005\u7684\u80a0\u9053\u5fae\u751f\u6001\u6270\u52a8\uff0c\u4ee5\u6539\u5584\u9884\u540e\u3002\u800c\u52a0\u5165\u76ca\u751f\u83cc\u5bf9\u6cbb\u7597\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u662f\u76f8\u5bf9\u5b89\u5168\u7684\uff0c\u5e76\u53ef\u80fd\u6709\u52a9\u4e8e\u6539\u5584\u5176\u9884\u540e\uff0c\u8fd9\u4e9b\u7814\u7a76\u6210\u679c\u5bf9\u4e8e\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u7684\u6cbb\u7597\u4ee5\u53ca\u9884\u540e\u90fd\u6709\u7740\u5f88\u91cd\u8981\u7684\u4e34\u5e8a\u610f\u4e49\u3002<\/div>\n
\u6587\u732e\u6765\u6e90\uff1aDOI\uff1a10.21203 \/ rs.3.rs-72753 \/ v1<\/div>\n
\u00a0<\/div>\n
\u63a8\u8350\u9605\u8bfb<\/div>\n
\u57fa\u56e0\u5468\u62a5\u4e28112\u671f<\/a><\/div>\n
Nature | \u5404\u56fd\u9632\u63a7\u65b0\u51a0\u518d\u7206\u53d1\uff0c\u57fa\u56e0\u79d1\u6280\u663e\u8eab\u624b<\/a><\/div>\n
\u57fa\u56e0\u6167\u5c06\u8054\u5408\u534e\u4e3a\u3001\u534e\u5927\u53d1\u5e03\u57fa\u56e0\u5927\u6570\u636e\u62a5\u544a<\/a><\/div>\n
\u3010\u58f0\u660e\u3011\u4e3a\u4f20\u64ad\u79d1\u5b66\u4fe1\u606f\uff0c\u63a8\u52a8\u57fa\u56e0\u53ca\u6570\u5b57\u751f\u547d\u5065\u5eb7\u4ea7\u5b66\u7814\u8fde\u63a5\uff0c\u6211\u4eec\u79c9\u6301\u4e2d\u7acb\u3001\u4e13\u4e1a\u3001\u8d4b\u80fd\u7684\u7406\u5ff5\u6536\u96c6\u3001\u5206\u6790\u6216\u53d1\u5e03\u4fe1\u606f\u3002\u4f46\u7531\u4e8e\u65f6\u6548\u6027\u53ca\u884c\u4e1a\u7279\u6b8a\u6027\uff0c\u6240\u520a\u767b\u5185\u5bb9\u4ec5\u4f9b\u7814\u7a76\u53c2\u8003\uff0c\u4e0d\u4f5c\u4e3a\u51b3\u7b56\u4f9d\u636e\uff1b\u672c\u6587\u76f8\u5173\u4fe1\u606f\u4e0d\u4ee3\u8868\u57fa\u56e0\u6167\u673a\u6784\u7684\u89c2\u70b9\uff1b\u201c\u57fa\u56e0\u6167\u201d\u520a\u767b\u7684\u539f\u521b\u5185\u5bb9\u7684\u77e5\u8bc6\u4ea7\u6743\u4e3a\u201c\u57fa\u56e0\u6167\u201d\u5546\u6807\u62e5\u6709\u8005\u53ca\u76f8\u5173\u6743\u5229\u4eba\u6240\u6709\uff1b\u6b22\u8fce\u8f6c\u8f7d\uff0c\u8f6c\u8f7d\u8bf7\u7533\u8bf7\u5e76\u6ce8\u660e\u6765\u6e90\u3002\u6b22\u8fce\u4e2a\u4eba\u53ca\u673a\u6784\u6295\u7a3f\u53ca\u5408\u4f5c\u3002<\/div>\n\n
\n
\"RmFicvQBAkgAeFMK0ia5Cab3334OUN1mUBG4bibxEzJJC01MPtSxIgRZcJvf6IGrU6cWAaTKdqM8GkEbzxEfFiaWCQ\"\/<\/figure><\/div>","protected":false},"excerpt":{"rendered":"

\u53ef\u80fd\u6709\u52a9\u4e8e\u6539\u5584\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u80a0\u9053\u5fae\u751f\u6001\u7a33\u5b9a\u6027<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[996],"tags":[1718,1717],"class_list":["post-9035","post","type-post","status-publish","format-standard","hentry","category-news","tag-1718","tag-1717"],"_links":{"self":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/9035","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/comments?post=9035"}],"version-history":[{"count":3,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/9035\/revisions"}],"predecessor-version":[{"id":13727,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/9035\/revisions\/13727"}],"wp:attachment":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/media?parent=9035"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/categories?post=9035"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/tags?post=9035"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}