112\u671f<\/div>\n
\u6587\u7ae0 | \u57fa\u56e0\u6167\u7f16\u8f91 | Shawne<\/div>\n
01\u00a0\u5934\u6761<\/div>\n
\u2756\u00a0\u534e\u5927\u8d1d\u745e\u7b49\u57fa\u56e0\u516c\u53f8\u5f00\u8bbe\u533b\u9662<\/div>\n
9\u67089\u65e5\u4e0a\u5348\uff0c\u6df1\u5733\u5e02\u534e\u5927\u533b\u9662\u8fd0\u8425\u534f\u8bae\u6b63\u5f0f\u7b7e\u7ea6\u3002\u6df1\u5733\u5e02\u534e\u5927\u533b\u9662\u5b9a\u4f4d\u4e3a\u5e02\u5c5e\u516c\u7acb\u533b\u9662\uff0c\u5c06\u7531\u6df1\u5733\u5e02\u536b\u751f\u5065\u5eb7\u59d4\u59d4\u6258\u6df1\u5733\u534e\u5927\u751f\u547d\u79d1\u5b66\u7814\u7a76\u9662\u8fd0\u8425\u3002<\/div>\n
\u6b64\u524d\uff0c\u636e\u798f\u5dde\u5e02\u4eba\u6c11\u653f\u5e9c\u5b98\u7f51\u62a5\u9053\uff0c\u798f\u5efa\u8d1d\u745e\u548c\u5eb7\u5065\u5eb7\u7ba1\u7406\u6709\u9650\u516c\u53f8\u4e8e2018\u5e74\u7533\u8bf7\u8bbe\u7f6e\u201c\u798f\u5dde\u8d1d\u745e\u548c\u5eb7\u80bf\u7624\u533b\u9662\u201d\uff08\u62df\u7533\u8bf7\u5e8a\u4f4d\u6570400\u5f20\uff0c\u62df\u6295\u8d44\u91d1\u989d\u7ea6\u4e3a7.13\u4ebf\u5143\uff09\u3002\u76f8\u5173\u56fe\u7eb8\u53d1\u5e03\u5728\u300a\u4e2d\u56fd\u533b\u9662\u5efa\u7b51\u4e0e\u88c5\u5907\u300b2019\u5e748\u671f\uff1b<\/div>\n
2017\u5e74\uff0c\u81fb\u548c\u79d1\u6280\u6210\u7acb\u81fb\u548c\u80bf\u7624\u4e13\u79d1\u95e8\u8bca\u90e8\u65e0\u9521\u6709\u9650\u516c\u53f8\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f><\/div>\n
\u57fa\u56e0\u516c\u53f8\u5f00\u533b\u9662\u4e0e\u533b\u9662\u5f15\u5165\u57fa\u56e0\u79d1\u6280<\/a><\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u56fd\u4ea7\u65b0\u578b\u624b\u6301\u5f0fQPCR\u5206\u6790\u7cfb\u7edf<\/div>\n
\u636e\u5a92\u4f53\u62a5\u9053\uff0c\u8fd1\u65e5\uff0c\u201c\u624b\u6301\u5168\u81ea\u52a8\u5c01\u95ed\u5f0f\u6838\u9178QPCR\u5206\u6790\u7cfb\u7edf\u201d CarryOn P1000Q\uff0c\u987a\u5229\u901a\u8fc7\u6d77\u5173\u603b\u7f72\u79d1\u6280\u53f8\u7ec4\u7ec7\u7684\u9879\u76ee\u9a8c\u6536\u3002\u8be5\u8bbe\u5907\u662f\u56fd\u5185\u81ea\u4e3b\u7814\u53d1\u7684\u65b0\u578b\u73b0\u573a\u5316\u5feb\u901f\u6838\u9178\u68c0\u6d4b\u8bbe\u5907\uff0c\u53ef40\u5206\u949f\u5b8c\u6210\u65b0\u51a0\u75c5\u6bd2\u7684\u73b0\u573a\u81ea\u52a8\u5316\u6838\u9178\u68c0\u6d4b\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0NCCN\u4e0d\u5efa\u8bae\u5728\u5e38\u89c4\u60a3\u8005\u7ba1\u7406\u4e2d<\/div>\n
\u4f7f\u7528\u591a\u57fa\u56e0\u98ce\u9669\u8bc4\u5206<\/div>\n
\u8fd1\u65e5\uff0cNCCN\u66f4\u65b0\u4e86\u5176\u8bc4\u4f30\u9057\u4f20\u6027\u4e73\u817a\u764c\uff0c\u5375\u5de2\u764c\u548c\u80f0\u817a\u764c\u98ce\u9669\u7684\u6307\u5357\uff0c\u5e76\u7279\u522b\u5efa\u8bae\u4e0d\u8981\u5728\u5e38\u89c4\u60a3\u8005\u7ba1\u7406\u4e2d\u4f7f\u7528\u591a\u57fa\u56e0\u98ce\u9669\u8bc4\u5206\uff08Polygenic risk score\uff0cPRS\uff09\u3002\u4e13\u5bb6\u5c0f\u7ec4\u5efa\u8bae\u76ee\u524d\u4e0d\u5e94\u5c06\u591a\u57fa\u56e0\u98ce\u9669\u8bc4\u5206\u7528\u4e8e\u4e34\u5e8a\u7ba1\u7406\uff0c\u6700\u597d\u5728\u4e34\u5e8a\u8bd5\u9a8c\u7684\u80cc\u666f\u4e0b\u4f7f\u7528\u6b64\u7c7b\u8bc4\u5206\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0FDA\u6279\u51c6\u7b2c\u4e8c\u6b3eRET\u9776\u5411\u836f\u53ca\u5176\u4f34\u968f\u8bca\u65ad<\/div>\n
2020\u5e749\u67087\u65e5\uff0cFDA\u6279\u51c6Blueprint\u65d7\u4e0b\u7684Gavreto\uff08pralsetinib\uff09\uff0c\u7528\u4e8e\u6cbb\u7597\u8840\u6db2\u6216\u7ec4\u7ec7\u68c0\u6d4bRET\u878d\u5408\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\uff08\u7ea6\u5360\u5230NSCLC\u76841%\u81f32%\u6bd4\u4f8b\uff09\u3002\u80ba\u764c\u9776\u5411\u836f\u7269\u7814\u53d1\u6b65\u5165\u7f55\u89c1\u9776\u70b9\u5f00\u53d1\u7684\u65f6\u4ee3\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0cGavreto\u5728\u4e2d\u56fd\u5e02\u573a\u5f52\u57fa\u77f3\u836f\u4e1a\u6240\u6709\uff0c\u7f57\u6c0f\u83b7\u5f97\u4e86Gavreto\u5728\u4e2d\u56fd\u548c\u7f8e\u56fd\u4ee5\u5916\u5e02\u573a\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u7684\u6743\u5229\u3002<\/div>\n
\u00a0<\/div>\n
02\u00a0\u653f\u7b56<\/div>\n
\u2756\u00a0\u4e60\u8fd1\u5e73\u5728\u79d1\u5b66\u5bb6\u5ea7\u8c08\u4f1a\u4e0a\u7684\u91cd\u8981\u8bb2\u8bdd<\/div>\n
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\u00a0<\/div>\n
\u2756\u00a0\u536b\u5065\u59d4\u8bbe\u7acb\u56fd\u5bb6\u513f\u7ae5\u533a\u57df\u533b\u7597\u4e2d\u5fc3\u4e3b\u4f53<\/div>\n
9\u67083\u65e5\uff0c\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u53d1\u5e03\u300a\u5173\u4e8e\u8bbe\u7f6e\u56fd\u5bb6\u513f\u7ae5\u533a\u57df\u533b\u7597\u4e2d\u5fc3\u7684\u901a\u77e5\u300b\uff0c\u660e\u786e\u5206\u522b\u5728\u4e1c\u5317\u3001\u534e\u4e1c\u3001\u4e2d\u5357\u3001\u897f\u5357\u548c\u897f\u5317\u533a\u57df\u8bbe\u7f6e\u56fd\u5bb6\u513f\u7ae5\u533a\u57df\u533b\u7597\u4e2d\u5fc3\u3002\u00a0\u8fd95\u4e2a\u56fd\u5bb6\u513f\u7ae5\u533a\u57df\u533b\u7597\u4e2d\u5fc3\u4e3b\u4f53\u5206\u522b\u4e3a\uff1a<\/div>\n
\u4e2d\u56fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u76db\u4eac\u533b\u9662<\/div>\n
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\u91cd\u5e86\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u513f\u7ae5\u533b\u9662<\/div>\n
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\u00a0<\/div>\n
\u2756\u00a0\u7b2c\u4e8c\u5c4a\u7f55\u89c1\u75c5\u8bca\u7597\u4e0e\u4fdd\u969c\u4e13\u5bb6\u59d4\u5458\u4f1a\u540d\u5355\u516c\u5e03<\/div>\n
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\u53c2\u8003\u4fe1\u606f>>http:\/\/www.nhc.gov.cn\/yzygj\/s7659\/202009\/c4cf28e6b54a4d248f0611b50dc023e7.shtml<\/div>\n
\u00a0<\/div>\n
\u57fa\u56e0\u6167\u5373\u5c06\u4e8e\u534e\u4e3a\u3001\u534e\u5927\u3001\u8bfa\u79be\u3001\u667a\u56e0\u4e1c\u65b9\u7b49<\/div>\n
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\u00a0\u542f\u52a8\u62db\u5546\u51a0\u540d\u5408\u4f5c<\/div>\n\n
\n![\"RmFicvQBAkgD71AN9kZJUpRYe1QXDla0b7P3K48fCIjkhibxsVA1AkYWicpiafaVMR6BqVV5e06DogibgFlEJiaelbicg\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgD71AN9kZJUpRYe1QXDla0b7P3K48fCIjkhibxsVA1AkYWicpiafaVMR6BqVV5e06DogibgFlEJiaelbicg.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u2756\u00a0\u6280\u672f\u8f6c\u8ba9\u6240\u5f97\u514d\u5f81\u989d\u63d0\u9ad8\u81f32000\u4e07\u5143<\/div>\n
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\u00a0<\/div>\n
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9\u67089\u65e5\uff0c\u7531\u8fea\u5b89\u8bca\u65ad\u3001\u676d\u5dde\u4e91\u533b\u8d2d\u3001\u6d59\u6c5f\u7701\u6807\u51c6\u5316\u7814\u7a76\u9662\u5171\u540c\u53d1\u8d77\u5236\u5b9a\u7684\u6d59\u6c5f\u7701\u6807\u51c6\u5316\u534f\u4f1a\u56e2\u4f53\u6807\u51c6 \u300a\u4f53\u5916\u8bca\u65ad\u8bd5\u5242\u552f\u4e00\u6807\u8bc6\u7f16\u7801\u89c4\u8303\u300b\u6b63\u5f0f\u53d1\u5e03\u3002\u4f5c\u4e3a\u5f00\u5c55\u7b2c\u4e09\u65b9\u533b\u5b66\u8bca\u65ad\u5de5\u4f5c\u7684\u91cd\u8981\u5de5\u5177\uff0c\u4f53\u5916\u8bca\u65ad\u8bd5\u5242\u80fd\u5426\u91c7\u7528\u56fd\u9645\u7edf\u4e00\u7684\u89c4\u5219\u8fdb\u884c\u7f16\u7801\uff0c\u5173\u7cfb\u7740\u4f53\u5916\u8bca\u65ad\u8bd5\u5242\u4e34\u5e8a\u5e94\u7528\u7684\u8d28\u91cf\u7ba1\u7406\uff0c\u4ee5\u53ca\u533b\u7597\u4f9b\u5e94\u94fe\u7684\u8fd0\u4f5c\u6548\u7387\u4e0e\u670d\u52a1\u8d28\u91cf\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u8bfa\u534eRNAi\u521b\u65b0\u7597\u6cd5\u5728\u534e\u83b7\u6279\u4e34\u5e8a<\/div>\n
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\u00a0<\/div>\n
03\u00a0\u4ea7\u4e1a<\/div>\n
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\n![\"RmFicvQBAkgD71AN9kZJUpRYe1QXDla0bhpJPymWviaCCbqcQfbjLg8G5QS9Lcpdbh4TQwOPX64DL1arV5hhXtPg\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgD71AN9kZJUpRYe1QXDla0bhpJPymWviaCCbqcQfbjLg8G5QS9Lcpdbh4TQwOPX64DL1arV5hhXtPg.png\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u8fd1\u671f\u56fd\u5185\u5916\u53d1\u5e03\u878d\u8d44\u52a8\u6001\u4f01\u4e1a\u5305\u62ec\u6052\u6da6\u8fbe\u751f\u3001\u51cc\u8fbe\u751f\u7269\u3001\u6167\u56e0\u6570\u636e\u3001\u96f6\u6c2a\u79d1\u6280\u3001\u65b0\u683c\u5143\u751f\u7269\u3001\u4e39\u5e8f\u751f\u7269\u3001\u4f18\u5723\u5eb7\u3001\u4f20\u4e16\u751f\u7269\u3001ACT Genomics\u3001Rain Therapeutics\u3001PicnicHealth\u3001bitBiome\u3001MicroGEN\u3001Catalog\u3001Korro Bio\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u7f8e\u56fd\u764c\u75c7\u65e9\u7b5b\u516c\u53f8Grail\u7533\u8bf7IPO<\/div>\n
\u5f53\u5730\u65f6\u95f49\u67089\u65e5\uff0c\u7f8e\u56fd\u764c\u75c7\u65e9\u7b5b\u516c\u53f8Grail\u5411\u7f8e\u56fd\u8bc1\u76d1\u4f1a\u9012\u4ea4\u4e86\u4e0a\u5e02\u7533\u8bf7\uff0c\u8be5\u516c\u53f8\u8ba1\u5212\u5728\u7eb3\u65af\u8fbe\u514b\u4e0a\u5e02\uff0c\u80a1\u7968\u4ea4\u6613\u4ee3\u7801\u4e3a\u201cGRAL\u201d\u3002\u6839\u636e\u62db\u80a1\u4e66\u6587\u4ef6\uff0cGRAIL\u516c\u53f8\u8ba1\u5212\u57282021\u5e74\u63a8\u51fa\u5176\u6db2\u4f53\u6d3b\u68c0\u4ea7\u54c1Galleri\uff0c\u4f5c\u4e3a\u4e00\u79cdLDT\u68c0\u6d4b\u7528\u4e8e50\u5c81\u4ee5\u4e0a\u7684\u65e0\u75c7\u72b6\u4eba\u7fa4\u7684\u764c\u75c7\u7b5b\u67e5\u3002Galleri\u76ee\u524d\u4ec5\u9002\u7528\u4e8eGRAIL\u4e34\u5e8a\u7814\u7a76\u7684\u53c2\u4e0e\u8005\uff0c\u65e8\u5728\u8865\u5145\u800c\u975e\u66ff\u4ee3\u7f8e\u56fd\u6307\u5357\u63a8\u8350\u7684\u764c\u75c7\u7b5b\u67e5\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u65b0\u7597\u6cd5\u516c\u53f8\u542f\u52a8IPO\u8ba1\u5212<\/div>\n
\u8fd1\u65e5\uff0c\u603b\u90e8\u4f4d\u4e8e\u897f\u96c5\u56fe\u7684\u751f\u7269\u533b\u836f\u516c\u53f8Athira Pharma\u5ba3\u5e03IPO\u8ba1\u5212\uff0c\u9884\u4f30\u878d\u8d44\u76ee\u6807\u4e3a1\u4ebf\u7f8e\u5143\u3002\u57286\u6708\u4efd\uff0cAthira\u516c\u53f8\u521a\u521a\u5b8c\u6210\u4e868500\u4e07\u7f8e\u5143\u7684B\u8f6e\u878d\u8d44\u3002Athira\u4e13\u6ce8\u4e8e\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u836f\u54c1\u7814\u53d1\uff0c\u516c\u53f8\u4e3b\u8981\u5728\u63a8\u8fdb\u7528\u4e8e\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u7684NDX-1017\u9879\u76ee\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a02019\u5e74\u5168\u56fd\u79d1\u6280\u7ecf\u8d39\u6295\u5165\u7edf\u8ba1\u516c\u62a5\u7ed3\u679c<\/div>\n
8\u670827\u65e5\uff0c\u56fd\u5bb6\u7edf\u8ba1\u5c40\u53d1\u5e03\u4e86\u201c2019\u5e74\u5168\u56fd\u79d1\u6280\u7ecf\u8d39\u6295\u5165\u7edf\u8ba1\u516c\u62a5\u201d\u3002\u516c\u62a5\u663e\u793a\uff0c2019\u5e74\u5168\u56fd\u5171\u6295\u5165R&D\u7ecf\u8d39\uff08\u7814\u53d1\u6295\u5165\uff09\u540c\u6bd4\u589e\u957f12.5%\u3002\u5317\u4e0a\u6df1\u4e09\u57ce\u7684\u7814\u53d1\u7ecf\u8d39\u76f8\u5f53\u4e8e\u5168\u56fd\u7814\u53d1\u7ecf\u8d39\u768420%\u30022019\u5e74\uff0c\u534e\u4e3a\u516c\u53f8\u7684\u7814\u53d1\u652f\u51fa\u5360\u5168\u56fd\u7814\u53d1\u7ecf\u8d39\u76846%\u3002\u5404\u7701\u7684\u7814\u53d1\u6295\u5165\u6392\u540d\u4e2d\uff0c\u5e7f\u4e1c\u3001\u6c5f\u82cf\u3001\u5317\u4eac\u53ef\u89c6\u4e3a\u7b2c\u4e00\u6863\uff0c\u6d59\u6c5f\u3001\u4e0a\u6d77\u3001\u5c71\u4e1c\u53ef\u89c6\u4e3a\u7b2c\u4e8c\u6863\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u9646\u9053\u57f9\u533b\u9662\u5f00\u5c55\u878d\u5408\u57fa\u56e0\u68c0\u6d4b<\/div>\n
\u8fd1\u65e5\uff0c\u9646\u9053\u57f9\u533b\u9662\u5206\u5b50\u533b\u5b66\u5ba4\u5f00\u5c55\u201c\u767d\u8840\u75c5\u5c11\u89c1\u878d\u5408\u57fa\u56e0\u53ca\u878d\u5408\u57fa\u56e0\u5bb6\u65cf\u6210\u5458\u5206\u6790\u201d\u9879\u76ee\u3002\u8be5\u9879\u76ee\u7528\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\u5168\u9762\u5206\u6790\u8840\u6db2\u80bf\u7624\u4e2d\u7684\u81f4\u75c5\u878d\u5408\u57fa\u56e0\uff0c\u80fd\u591f\u6709\u6548\u5206\u6790\u5e38\u89c1\u878d\u5408\u57fa\u56e0\u3001\u878d\u5408\u57fa\u56e0\u5bb6\u65cf\u548c\u5c11\u89c1\u3001\u53d8\u5f02\u578b\u878d\u5408\u57fa\u56e0\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0Illumina\u4e0e54gene\u5408\u4f5c\u5728\u5c3c\u65e5\u5229\u4e9a\u5efa\u7acb\u57fa\u56e0\u7ec4\u5b66\u8bbe\u65bd<\/div>\n
9\u67083\u65e5\uff0cIllumina\u5ba3\u5e03\u4e0e\u5065\u5eb7\u6280\u672f\u516c\u53f854gene\u8fbe\u6210\u5408\u4f5c\uff0c\u652f\u6301\u5728\u5c3c\u65e5\u5229\u4e9a\u5efa\u7acb\u4e00\u4e2a\u65b0\u7684\u57fa\u56e0\u7ec4\u5b66\u8bbe\u65bd\uff0c\u5305\u62ec\u914d\u5907\u4e86\u4e00\u7cfb\u5217Illumina\u7684\u5148\u8fdb\u6d4b\u5e8f\u4eea\u548c\u9ad8\u5bc6\u5ea6\u5fae\u9635\u5217\u6280\u672f\u5e73\u53f0\uff0c\u4e3a\u5065\u5eb7\u7814\u7a76\u548c\u836f\u7269\u5f00\u53d1\u63d0\u4f9b\u9057\u4f20\u4fe1\u606f\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u9996\u6b3e\u6cbb\u7597\u60f0\u6027\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684<\/div>\n
CAR-T\u7597\u6cd5\u6709\u671b\u8bde\u751f<\/div>\n
\u8fd1\u65e5\uff0c\u5409\u5229\u5fb7\u79d1\u5b66\uff08Gilead Sciences\uff09\u516c\u53f8\u65d7\u4e0bKite\u516c\u53f8\u5ba3\u5e03\uff0c\u5df2\u5411\u7f8e\u56fdFDA\u63d0\u4ea4\u4e86CAR-T\u7ec6\u80de\u7597\u6cd5Yescarta\uff08axicabtagene ciloleucel\uff09\u7684\u8865\u5145\u751f\u7269\u5236\u54c1\u8bb8\u53ef\u7533\u8bf7\uff08sBLA\uff09\uff0c\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\uff08NHL\uff09\u548c\u8fb9\u7f18\u533a\u6dcb\u5df4\u7624\u60a3\u8005\uff0c\u4ed6\u4eec\u5df2\u7ecf\u63a5\u53d7\u8fc7\u4e24\u6b21\u4ee5\u4e0a\u7684\u5168\u8eab\u6027\u7597\u6cd5\u3002\u5982\u679c\u83b7\u6279\uff0cYescarta\u5c06\u6210\u4e3a\u9996\u4e2a\u83b7\u6279\u7528\u4e8e\u6cbb\u7597NHL\u7684CAR-T\u7ec6\u80de\u7597\u6cd5\u3002<\/div>\n
\u00a0<\/div>\n
04\u00a0\u79d1\u7814<\/div>\n
\u275615\u7bc7\u4eba\u7c7b\u9057\u4f20\u8c03\u63a7\u65b0\u6210\u679c\u53d1\u5e03<\/div>\n
\u8fd1\u65e5\uff0c\u201c\u57fa\u56e0\u578b-\u7ec4\u7ec7\u8868\u8fbe\u7814\u7a76\u8054\u76df\u201d\uff08Genotype-Tissue Expression Consortium\uff09\u7ed3\u675f\u4e86\u4e3a\u671f10\u5e74\u7684\u591a\u673a\u6784\u7814\u7a76\u5de5\u4f5c\uff0c\u4e8eScience\u3001Cell\u7b49\u671f\u520a\u53d1\u5e03\u4e86\u65a5\u8d441.5\u4ebf\u7f8e\u5143\u7684\u201c\u57fa\u56e0\u578b-\u7ec4\u7ec7\u8868\u8fbe\u9879\u76ee\u201d\uff08The Genotype-Tissue Expression (GTEx) Project\uff09\u6700\u540e\u4e00\u671f\u5171\u8ba115\u9879\u7814\u7a76\u6210\u679c\uff0c\u4ecb\u7ecd\u4e86\u8de8\u7ec6\u80de\u7c7b\u578b\u548c\u7ec4\u7ec7\u7684\u9057\u4f20\u8c03\u63a7\u53d8\u5f02\u7efc\u5408\u56fe\u8c31\uff0c\u5e76\u5206\u6790\u4e86\u8fd9\u4e9b\u8c03\u63a7\u53d8\u5316\u5982\u4f55\u589e\u52a0\u75be\u75c5\u98ce\u9669\u548c\u4fc3\u8fdb\u75be\u75c5\u7279\u5f81\u7684\u53d1\u5c55\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>http:\/\/www.gtexportal.org\/home\/<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u5251\u6865\u5927\u5b66\u5f00\u53d1\u51fa\u9884\u6d4b\u98df\u7ba1\u764c\u98ce\u9669\u7684\u751f\u7269\u4fe1\u606f\u6a21\u578b<\/div>\n
\u8fd1\u65e5\uff0c\u5251\u6865\u5927\u5b66\u7814\u7a76\u56e2\u961f\u8054\u5408EMBL\u6b27\u6d32\u751f\u7269\u4fe1\u606f\u5b66\u7814\u7a76\u6240\u7b49\u5408\u4f5c\u8005\uff0c\u6839\u636e\u6765\u81ea\u5df4\u6c0f\u98df\u9053\u75c7\u60a3\u8005\u6d3b\u68c0\u7ec4\u7ec7\u7684\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6570\u636e\u5f00\u53d1\u4e86\u4e00\u79cd\u7edf\u8ba1\u6a21\u578b\uff0c\u53d1\u73b0\u5229\u7528\u5168\u57fa\u56e0\u7ec4\u62f7\u8d1d\u6570\u4e0d\u7a33\u5b9a\u6027\u4f5c\u4e3a\u764c\u75c7\u8fdb\u5c55\u98ce\u9669\u7684\u6807\u5fd7\u7269\uff0c\u53ef\u5728\u786e\u8bca\u524d\u6570\u5e74\u51c6\u786e\u9884\u6d4b\u5df4\u6c0f\u98df\u9053\u75c7\u60a3\u8005\u7f79\u60a3\u98df\u7ba1\u764c\u7684\u98ce\u9669\u3002\u8be5\u7814\u7a76\u53d1\u8868\u5728Nature Medicine\u4e0a\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>DOI: 10.1038\/s41591-020-1033-y<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u5362\u715c\u660e\u5173\u4e8e\u6db2\u4f53\u6d3b\u68c0\u7684\u6700\u65b0\u7814\u7a76<\/div>\n
\u8fd1\u65e5\uff0c\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\u5362\u715c\u660e\u6559\u6388\u7814\u7a76\u56e2\u961f\u5f00\u53d1\u4e86\u57fa\u4e8e\u7532\u57fa\u5316\u7684\u65b9\u6cd5\u4ee5\u5206\u6790cfDNA\u7247\u6bb5\u7684\u201cjagged ends\uff08\u952f\u9f7f\u672b\u7aef\uff09\u201d\u3002\u7ed3\u679c\u663e\u793a\uff0c\u5927\u591a\u6570\uff0887.8%\uff09cfDNA\u5206\u5b50\u5b58\u5728\u952f\u9f7f\u672b\u7aef\u3002\u6b64\u5916\uff0c\u952f\u9f7f\u7a0b\u5ea6\u968f\u8840\u6d46DNA\u7247\u6bb5\u5927\u5c0f\u800c\u53d8\u5316\uff0c\u4e14\u4e0e\u6838\u5c0f\u4f53\u6a21\u5f0f\u6709\u5173\u3002\u8be5\u7814\u7a76\u6210\u679c\u5df2\u5728Genome Research\u53d1\u8868\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>Doi: 10.1101\/gr.261396.120<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6700\u65b0\u5229\u597d\u7ed3\u679c<\/div>\n
Bluebird Bio\u57289\u67081\u65e5\u4e3e\u884c\u7684\u7b2c46\u5c4a\u6b27\u6d32\u8840\u6db2\u548c\u9aa8\u9ad3\u79fb\u690d\u5b66\u4f1a\u5e74\u4f1a\u4e0a\u5bf9\u5916\u516c\u5e03\u4e86\u5176\u57fa\u56e0\u6cbb\u7597\u836f\u7269Lenti-D\uff08\u4e00\u6b3e\u6cbb\u7597\u8111\u6027\u80be\u4e0a\u817a\u76ae\u8d28\u8425\u517b\u4e0d\u826f\u75c7\uff08cerebral adrenoleukodystrophy\uff0c CALD\uff09\u7684\u57fa\u56e0\u6cbb\u7597\u836f\u7269\uff09\u7684\u6700\u65b0\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u3002<\/div>\n
\u5728Lenti-D\u7684\u4e34\u5e8aII\/III\u671f\u8bd5\u9a8c\u4e2d\uff08ALD-102\uff09\uff0c\u670987%\u7684\u60a3\u8005\u5728\u63a5\u53d7\u6cbb\u7597\u768424\u4e2a\u6708\u751a\u81f3\u66f4\u4e45\u7684\u65f6\u95f4\u5185\u4f9d\u65e7\u60c5\u51b5\u7a33\u5b9a\uff0c\u4e14\u6ca1\u6709\u91cd\u5927\u7cfb\u7edf\u6027\u75be\u75c5\u7684\u53d1\u751f\uff0c\u540c\u65f6\u6ca1\u6709\u4efb\u4f55\u4e00\u4f4d\u60a3\u8005\u66fe\u51fa\u73b0\u79fb\u690d\u5931\u8d25\u3001\u79fb\u690d\u6392\u65a5\u3001\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\u7684\u73b0\u8c61\uff0c\u5728\u5305\u62ec10\u540d\u7537\u7ae5\u60a3\u8005\u5728\u5185\u7684\u4e94\u5e74\u957f\u671f\u968f\u8bbf\u4e2d\uff0cLenti-D\u88ab\u8bc1\u5b9e\u4e86\u5177\u6709\u8f83\u4e3a\u7a33\u5b9a\u4e14\u6301\u4e45\u7684\u6cbb\u7597\u6548\u679c\u3002<\/div>\n
\u00a0<\/div>\n
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