{"id":9020,"date":"2020-10-11T21:55:09","date_gmt":"2020-10-11T13:55:09","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&mid=100016617&idx=1&sn=65e1b4a1e60699e93b934877e96df67b&chksm=6b71735e5c06fa48aa6edac129354eb198bfa101fe97b2c0a00b8c6fa9b567ff8627accadc2a#rd"},"modified":"2026-04-01T17:07:28","modified_gmt":"2026-04-01T09:07:28","slug":"985557","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2020\/10\/11\/985557\/","title":{"rendered":"\u5468\u62a5\u4e28\u9996\u4e2a\u65b0\u51a0POCT\u6297\u4f53\u68c0\u6d4b\u83b7FDA\u6388\u6743\uff0cNatera NIPT\u7684\u8986\u76d6\u8303\u56f4\u6269\u5927\u81f3\u6240\u6709\u5b55\u5987"},"content":{"rendered":"
\n
\"RmFicvQBAkgB9j74Mcian6QwyibibI4PagzBGBHnqMiazSJibpqzdMZTuCTIeUBH9Oq9bGsvWuFianWaiaZc4XjyyA2ibUA\"\/<\/figure><\/div>\n\n
\u56fe\uff1a\u4e0b\u4e00\u4ee3\u7ec4\u5b66\u5206\u6790\u5de5\u5177DrBioRight\u5206\u6790\u6d41\u7a0b\u6982\u8ff0<\/div>\n
doi:10.1016\/j.ccell.2020.09.002<\/div>\n
\u5934\u6761<\/div>\n
\u2756FDA\u6388\u6743\u9996\u4e2a\u65b0\u51a0POCT\u6297\u4f53\u68c0\u6d4b<\/div>\n
\u8fd1\u65e5\uff0cFDA\u6388\u4e88\u9996\u4e2aCOVID-19\u7684\u8840\u6e05\u5b66\uff08\u6297\u4f53\uff09POCT\u6d4b\u8bd5\u7d27\u6025\u4f7f\u7528\u6388\u6743\uff08EUA\uff09\u3002\u5373\u6307\u5c16\u91c7\u96c6\u7684\u8840\u6db2\u6837\u672c\u53ef\u5728POCT\u73af\u5883\u4e0b\uff08\u5982\u533b\u751f\u529e\u516c\u5ba4\u3001\u533b\u9662\u3001\u7d27\u6025\u62a4\u7406\u4e2d\u5fc3\u548c\u6025\u8bca\u5ba4\uff09\u8fdb\u884c\u68c0\u6d4b\uff0c\u800c\u4e0d\u5fc5\u9001\u5230\u4e2d\u5fc3\u5b9e\u9a8c\u5ba4\u8fdb\u884c\u68c0\u6d4b\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/www.fda.gov\/media\/139789\/download<\/div>\n
\u00a0<\/div>\n
\u2756Centene\u5c06Natera NIPT\u7684\u8986\u76d6\u8303\u56f4\u6269\u5927\u81f3\u6240\u6709\u5b55\u5987<\/div>\n
10\u67088\u65e5\uff0cNatera\u8868\u793a\uff0c\u4fdd\u9669\u516c\u53f8Centene\u5df2\u5c06\u5176PanoramaTM\u7684\u65e0\u521b\u4ea7\u524d\u68c0\u67e5\u7684\u8986\u76d6\u8303\u56f4\u6269\u5927\u5230\u6240\u6709\u5b55\u5987\uff0c\u5305\u62ec\u4e2d\u7b49\u98ce\u9669\u548c\u53cc\u80ce\u598a\u5a20\u3002\u672c\u6b21\u6269\u5927\u8986\u76d6\u8303\u56f4\u662f\u5728\u7f8e\u56fd\u5987\u4ea7\u79d1\u5b66\u9662\uff08ACOG\uff09\u548c\u6bcd\u5a74\u533b\u5b66\u534f\u4f1a\uff08SMFM\uff09\u6700\u8fd1\u53d1\u5e03\u4e86\u65b0\u7684\u8054\u5408\u6307\u5357<\/a>\u4e4b\u540e\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/www.genomeweb.com\/molecular-diagnostics\/centene-expands-coverage-natera-nipt-all-pregnant-women#.X4FREkUzbZs<\/div>\n
\u00a0<\/div>\n
\u653f\u7b56<\/div>\n
\u2756\u00a0CDE\uff1a\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u6307\u5bfc\u539f\u5219\u5f81\u6c42\u610f\u89c1<\/div>\n
\u4e3a\u4e86\u89c4\u8303\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u7684\u836f\u5b66\u7814\u7a76\uff0c\u7edf\u4e00\u8bc4\u4ef7\u6807\u51c6\uff0c\u5f15\u5bfc\u514d\u75ab\u6cbb\u7597\u7ec6\u80de\u4ea7\u54c1\u7684\u7814\u7a76\u4e0e\u7533\u62a5\uff0c9\u670830\u65e5\uff0c\u56fd\u5bb6\u836f\u76d1\u5c40\u836f\u5ba1\u4e2d\u5fc3\uff08CDE\uff09\u7f51\u7ad9\u53d1\u5e03\u5173\u4e8e\u516c\u5f00\u5f81\u6c42\u300a\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u836f\u5b66\u7814\u7a76\u4e0e\u8bc4\u4ef7\u6280\u672f\u6307\u5bfc\u539f\u5219\uff08\u5f81\u6c42\u610f\u89c1\u7a3f\uff09\u300b\u610f\u89c1\u7684\u901a\u77e5\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>http:\/\/www.cde.org.cn\/news.do?method=viewInfoCommon&id=060e801824cfa767<\/div>\n
\u6700\u65b0\u300a\u7ec6\u80de\u548c\u57fa\u56e0\u6cbb\u7597\u884c\u7814\u62a5\u544a\u300b<\/a><\/div>\n
\u00a0\u62db\u5546\u51a0\u540d\u5408\u4f5c\u8fdb\u884c\u4e2d<\/a><\/div>\n\n
\n
\"RmFicvQBAkgB9j74Mcian6QwyibibI4PagzBHuR9HUUhdw57389KQPcECcNYL7ib86qXwouA9E0ARJx44mxGficqRr4w\"\/<\/figure><\/div>\n\n
\u2756\u00a0\u82f1\u56fd\u653f\u5e9c\u516c\u5e03\u65b0\u7684\u56fd\u5bb6\u57fa\u56e0\u7ec4\u5065\u5eb7\u533b\u7597\u6218\u7565<\/div>\n
\u65e5\u524d\uff0c\u82f1\u56fd\u653f\u5e9c\u53d1\u5e03\u5176\u56fd\u5bb6\u57fa\u56e0\u7ec4\u5065\u5eb7\u533b\u7597\u6218\u7565Genome UK\uff0c\u627f\u8bfa\u4ee5\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u4e3a\u57fa\u7840\uff0c\u4e3a\u60a3\u8005\u63d0\u4f9b\u6700\u4f73\u7684\u9884\u6d4b\u3001\u9884\u9632\u548c\u4e2a\u6027\u5316\u62a4\u7406\u3002\u8be5\u7b56\u7565\u5305\u62ec3\u4e2a\u5173\u952e\u9886\u57df\uff1a\u8bca\u65ad\u548c\u4e2a\u6027\u5316\u533b\u5b66\uff08Diagnosis and personalised medicine\uff09\u3001\u9884\u9632\uff08Prevention\uff09\u4ee5\u53ca\u7814\u7a76\uff08Research\uff09\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/www.gov.uk\/government\/news\/landmark-strategy-launched-to-cement-uks-position-as-global-leader-in-genomics<\/div>\n
\u00a0<\/div>\n
\u79d1\u7814<\/div>\n
\u2756\u00a0\u65b0CAR-T\u7597\u6cd5\u6709\u671b\u6cbb\u7597<\/div>\n
\u7c98\u819c\u5bfb\u5e38\u578b\u5929\u75b1\u75ae\u7b49\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5<\/div>\n
\u8fd1\u65e5\uff0c\u7f8e\u56fd\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u5728\u52a8\u7269\u6a21\u578b\u4e2d\uff0c\u4e00\u79cd\u6cbb\u7597\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7c98\u819c\u5bfb\u5e38\u578b\u5929\u75b1\u75ae\uff08pemphigus vulgaris, PV\uff09\u7684\u65b0\u7684\u7ec6\u80de\u9776\u5411\u7597\u6cd5\u662f\u5b89\u5168\u800c\u6709\u6548\u7684\u3002\u7814\u7a76\u4eba\u5458\u62a5\u544a\u4e86\u79f0\u4e3aDSG3\u5d4c\u5408\u81ea\u8eab\u6297\u4f53\u53d7\u4f53T\u7ec6\u80de\uff08desmoglein 3 chimeric autoantibody receptor T cell, DSG3-CAART\uff09\u7684\u65b0\u7b56\u7565\u5728\u4e00\u7cfb\u5217\u4e34\u5e8a\u524d\u6d4b\u8bd5\u4e2d\u53d6\u5f97\u6210\u529f\u3002\u8be5\u7814\u7a76\u4e3a\u53ef\u80fd\u5f00\u53d1\u57fa\u4e8e\u7ec6\u80de\u7684\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u65b0\u7597\u6cd5\u5efa\u7acb\u4e86\u4e34\u5e8a\u524d\u6d4b\u8bd5\u6a21\u5f0f\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/www.jci.org\/articles\/view\/138416<\/div>\n
\u00a0<\/div>\n
\u2756\u795e\u7ecf\u53d1\u751f\u57fa\u56e0\u7684\u7a81\u53d8\u53ef\u589e\u52a0\u8111\u762b\u98ce\u9669<\/div>\n
\u8fd1\u65e5\uff0c\u7f8e\u56fd\u7814\u7a76\u4eba\u5458\u5bf9250\u5bf9\u7236\u6bcd-\u540e\u4ee3\u8fdb\u884c\u4e86\u5168\u5916\u663e\u5b50\u6d4b\u5e8f\uff0c\u5e76\u89c2\u5bdf\u5230\u8111\u762b\u75c5\u4f8b\u4e2d\u6709\u5bb3\u4ece\u5934\u7a81\u53d8\u7684\u4e30\u5bcc\u6027\uff0c\u786e\u5b9a\u4e86\u4e24\u79cd\u65b0\u9896\u7684\u5355\u57fa\u56e0\u75c5\u56e0\uff0cFBXO31\u548cRHOB\uff0c\u5e76\u663e\u793aRHOB\u7a81\u53d8\u589e\u5f3a\u4e86\u6d3b\u6027\u72b6\u6001Rho\u6548\u5e94\u5b50\u7684\u7ed3\u5408\uff0c\u800cFBXO31\u7a81\u53d8\u5219\u964d\u4f4e\u4e86\u7ec6\u80de\u5468\u671f\u86cb\u767dD\u7684\u6c34\u5e73\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>DOI: 10.1038\/s41588-020-0695-1<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u4e0b\u4e00\u4ee3\u7ec4\u5b66\u5206\u6790\u667a\u80fd\u5de5\u5177DrBioRight<\/div>\n
9\u670824\u65e5\uff0c\u7f8e\u56fdMD\u5b89\u5fb7\u68ee\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3\u6881\u6657\u8bfe\u9898\u7ec4\u5728Cancer Cell\u4e0a\u53d1\u6587\u62a5\u9053\u4e86\u4e00\u79cd\u7b80\u5355\u6613\u884c\u7684\u4e0b\u4e00\u4ee3\u7ec4\u5b66\u6570\u636e\u5206\u6790\u5de5\u5177—DrBioRight\u3002\u8be5\u5de5\u5177\u7531\u7814\u7a76\u56e2\u961f\u5386\u65f6\u4e09\u5e74\u63a8\u51fa\uff0c\u5c06\u4ea7\u751f\u4e00\u79cd\u4ee5\u81ea\u7136\u8bed\u8a00\u548c\u4eba\u5de5\u667a\u80fd\u4ea4\u4e92\u4e3a\u6838\u5fc3\u7684\u4e0b\u4e00\u4ee3\u7ec4\u5b66\u6570\u636e\u5206\u6790\u8303\u5f0f\uff0c\u4f7f\u7ec4\u5b66\u6570\u636e\u7684\u6548\u7528\u6700\u5927\u5316\uff0c\u540c\u65f6\u52a0\u901f\u751f\u7269\u533b\u5b66\u7814\u7a76\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/doi.org\/10.1016\/j.ccell.2020.09.002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0MSI-H\u4e0e\u57fa\u56e0\u878d\u5408\u5171\u53d8\u5f02\u5173\u8054\u6027\u7814\u7a76\u65b0\u6210\u679c<\/div>\n
\u8fd1\u65e5\uff0c\u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662\u7b26\u6d9b\u6559\u6388\u4e0e\u601d\u8def\u8fea\u533b\u5b66\u90e8\u5408\u4f5c\uff0c\u57fa\u4e8e20296\u4f8b\u6cdb\u764c\u79cd\u60a3\u8005\u6570\u636e\u5206\u6790\u4e86MSI-H\u4e0e\u57fa\u56e0\u878d\u5408\u5171\u53d8\u5f02\u7684\u5173\u8054\u6027\uff0c\u7814\u7a76\u7ed3\u679c\u5165\u90092020\u5e74ESMO\u5e74\u4f1amini oral presentaion\u3002\u8be5\u7814\u7a76\u63ed\u793a\u4e86\u5b9e\u4f53\u80bf\u7624\uff0c\u7279\u522b\u662f\u80a0\u764c\u4e2d\uff0c\u53ef\u7528\u836f\u9776\u70b9\u7684\u57fa\u56e0\u878d\u5408\u53d1\u751f\u4e0eMSI-H\u5448\u6b63\u76f8\u5173\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u9996\u4f8bPD-1\u6572\u9664\u975e\u75c5\u6bd2CAR-T\u6cbb\u7597<\/div>\n
9\u670825\u65e5\uff0c\u4e0a\u6d77\u90a6\u8000\u751f\u7269\u9996\u6b21\u5bf9\u5916\u516c\u5e03\u4e86\u4e0e\u6d59\u6c5f\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u5408\u4f5c\u5f00\u5c55\u7684\u201cPD1\u6572\u9664\u975e\u75c5\u6bd2\u5b9a\u70b9\u6574\u5408CD19-CART\u7ec6\u80de\u6cbb\u7597\u590d\u53d1\u96be\u6cbb\u6027\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u4e34\u5e8a\u8bd5\u9a8c\u201d\u65b0\u6210\u679c\u3002\u8fd9\u662f\u4e16\u754c\u4e0a\u9996\u6b21\u5229\u7528\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u5728PD1\u4f4d\u70b9\u5b9e\u73b0\u5b9a\u70b9\u6574\u5408\u7684CART\u6cbb\u7597\uff0c\u4e5f\u662f\u5168\u7403\u9996\u4f8b\u975e\u75c5\u6bd2\u5b9a\u70b9\u6574\u5408CART\u7ec6\u80de\u6cbb\u7597\u6dcb\u5df4\u7624\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/doi.org\/10.1101\/2020.09.22.20199786<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u53d1\u660e\u8005\u83b7\u8bfa\u5956<\/div>\n
10\u67087\u65e5\uff0c\u8bfa\u8d1d\u5c14\u5956\u5316\u5b66\u5956\u6388\u4e88\u4e86\u57fa\u56e0\u7f16\u8f91\u9886\u57df\u7684\u4e24\u4f4d\u5148\u9a71\u3002\u52a0\u5dde\u5927\u5b66\u4f2f\u514b\u5229\u5206\u6821\u6559\u6388\u8a79\u59ae\u5f17\u00b7\u675c\u5fb7\u7eb3\uff08Jennifer Doudna\uff09\u548c\u5fb7\u56fd\u9a6c\u666e\u611f\u67d3\u751f\u7269\u5b66\u7814\u7a76\u6240\u6559\u6388\u57c3\u9a6c\u7ebd\u5c14\u00b7\u590f\u5f6d\u8482\u8036\uff08Emmanuelle Charpentier\uff09\u83b7\u5f972020\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\uff0c\u4ee5\u8868\u5f70\u5979\u4eec\u201c\u5f00\u53d1\u51fa\u4e00\u79cd\u57fa\u56e0\u7ec4\u7f16\u8f91\u65b9\u6cd5\u201d\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u63ed\u793a\u771f\u5b9e\u7684\u65b0\u51a0\u75c5\u6bd2\u5206\u5b50\u7ed3\u6784<\/div>\n
\u8fd1\u65e5\uff0c\u6e05\u534e\u5927\u5b66\u548c\u6d59\u6c5f\u5927\u5b66\u7b49\u7814\u7a76\u673a\u6784\u7684\u7814\u7a76\u4eba\u5458\u62a5\u9053\u4e86\u771f\u5b9e\u7684SARS-CoV-2\u75c5\u6bd2\u7684\u5206\u5b50\u7ed3\u6784\u3002\u7814\u7a76\u4eba\u5458\u63ed\u793a\u51faSARS-CoV-2\u6838\u7cd6\u6838\u86cb\u767d\u7684\u5929\u7136\u6784\u8c61\u53ca\u5176\u9ad8\u9636\u7ec4\u88c5\u4f53\uff0c\u5e76\u9610\u660e\u4e86\u8fd9\u79cd\u75c5\u6bd2\u5982\u4f55\u5c06\u5b83\u7684\u957f\u8fbe\u5927\u7ea630 kb\u7684\u5355\u5206\u6bb5RNA\u5305\u88c5\u5728\u76f4\u5f84\u4e3a\u5927\u7ea680 nm\u7684\u58f3\u4f53\u5185\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u4e8e\u5728\u7ebf\u53d1\u8868\u5728Cell\u4e0a\u3002<\/div>\n
\u63a8\u8350\u9605\u8bfb>><\/div>\n
\u4e00\u79cd\u7279\u6b8a\u7684\u4fe1\u53f7\u901a\u8def\u53ef\u7528\u4e8e\u6cbb\u7597COVID-19\u5f15\u53d1\u7684\u80ba\u90e8\u75be\u75c5<\/a><\/div>\n
\u00a0<\/div>\n
\u4ea7\u4e1a<\/div>\n
\u2756 9\u5bb6\u4f01\u4e1a\u878d\u8d44\u4fe1\u606f<\/div>\n\n
\n
\"RmFicvQBAkgA6OibXMqTRpSce740E3R3vKWx8qUo5wSSnvHjc96U9zArKiarLic9nMj6zLAgu2DEicRCc2AID5eDlicg\"\/<\/figure><\/div>\n\n
\u56fe\uff1a\u4f01\u4e1a\u878d\u8d44\u4fe1\u606f\uff08\u6765\u6e90\/\u57fa\u56e0\u6167\uff09<\/div>\n
\u8fd1\u671f\u56fd\u5185\u5916\u53d1\u5e03\u878d\u8d44\u52a8\u6001\u4f01\u4e1a\u5305\u62ec\u4e88\u679c\u751f\u7269\u3001\u601d\u8def\u8fea\u533b\u836f\u3001\u5eb7\u7acb\u660e\u751f\u7269\u3001\u518d\u9f0e\u533b\u836f \u3001\u771f\u8fc8\u751f\u7269\u3001\u6676\u6cf0\u79d1\u6280\u3001Scribe Therapeutics\u3001Talaris Therapeutics\u3001Sophia Genetics\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a010x\u6536\u8d2d\u4e24\u5bb6\u4f01\u4e1a\u8fdb\u519b\u65b0\u5174\u539f\u4f4d\u5206\u6790\u9886\u57df<\/div>\n
10\u67085\u65e5\uff0c10x Genomics\u5ba3\u5e03\u6536\u8d2d\u4e24\u5bb6\u539f\u4f4d\u5206\u6790\u6280\u672f\u5f00\u53d1\u516c\u53f8\uff1aReadCoor\u548cCartana\u3002\u5176\u4e2d\uff0c\u4ee53.5\u4ebf\u7f8e\u5143\u6536\u8d2dReadCoor\uff0c\u8be5\u516c\u53f8\u5728\u4eca\u5e742\u6708\u7684\u57fa\u56e0\u7ec4\u751f\u7269\u5b66\u548c\u6280\u672f\u8fdb\u6b65\u4f1a\u8bae\u4e0a\u53d1\u5e03\u4e86\u57fa\u4e8e\u8367\u5149\u539f\u4f4d\u6d4b\u5e8f\u6280\u672f\u7684RC2\u7a7a\u95f4\u591a\u7ec4\u5b66\u5e73\u53f0\uff1b10x\u8fd8\u900f\u9732\uff0c\u5b83\u4e8e8\u6708\u5e95\u4ee54120\u4e07\u7f8e\u5143\u6536\u8d2d\u4e86\u539f\u4f4dRNA\u5206\u6790\u6280\u672f\u7684\u5f00\u53d1\u5546Cartana\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0Qiagen\u65b0\u68c0\u6d4b\u8bd5\u52421\u5c0f\u65f6\u5185\u5b8c\u6210PCR\u5206\u6790\u00a0\u00a0<\/div>\n
10\u67085\u65e5\uff0cQIAGEN \u63a8\u51fa\u65b0 PCR \u68c0\u6d4b\u8bd5\u5242\u5957\u7ec4\uff0c\u5b83\u5c06\u6837\u54c1\u5236\u5907\u6b65\u9aa4\u4e0e\u5b9e\u65f6 PCR\uff08real-time PCR\uff09 \u7ed3\u5408\uff0c\u7b80\u5316\u4e86\u5de5\u4f5c\u6d41\u7a0b\uff0c\u4ece\u8bd5\u9a8c\u5f00\u59cb\u5230\u7ed3\u679c\u8f93\u51fa\u7684\u65f6\u95f4\u4e0d\u5230 1 \u5c0f\u65f6\uff0c\u5c06\u53ef\u80fd\u6253\u7834 SARS-CoV-2 \u6216\u5176\u4ed6 RNA \u75c5\u6bd2\u7684\u68c0\u9a8c\u74f6\u9888\uff0c\u6210\u4e3a\u6291\u5236\u75ab\u60c5\u7684\u4e00\u5927\u6218\u529b\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0PacBio\u63a8\u51fa\u65b0\u7684\u6d4b\u5e8f\u7cfb\u7edfSequel\u00aeIIe<\/div>\n
\u7f8e\u56fd\u592a\u5e73\u6d0b\u65f6\u95f410\u67085\u65e5 \u2013 PacBio\u5ba3\u5e03\u63a8\u51fa\u65b0\u7684Sequel\u00aeIIe\u6d4b\u5e8f\u7cfb\u7edf\uff0c Sequel\u00aeIIe\u662f\u57fa\u4e8ePacBio\u5355\u5206\u5b50\u5b9e\u65f6\uff08SMRT\u00ae\uff09\u6d4b\u5e8f\u6280\u672f\u5f00\u53d1\u7684\u6700\u65b0\u7684\u957f\u8bfb\u957f\u6d4b\u5e8f\u4eea\u3002\u901a\u8fc7\u589e\u52a0\u4eea\u5668\u5185\u90e8\u7684\u6570\u636e\u5904\u7406\u548c\u8fd0\u7b97\u80fd\u529b\uff0c\u66f4\u7ecf\u6d4e\u9ad8\u6548\u5730\u76f4\u63a5\u4ea7\u751f\u9ad8\u7cbe\u5ea6\u7684\u957f\u8bfb\u957f\uff08HiFi reads\uff09\u6570\u636e\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u8f89\u745e\u3001Sangamo\u00a0\u57fa\u56e0\u7597\u6cd5\u8fdb\u7b2c\u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/div>\n
\u7f8e\u56fd\u65f6\u95f410\u67087\u65e5\uff0c\u8f89\u745e\u00a0\u4e0e Sangamo Therapeutics \u8054\u624b\u7814\u53d1\u7684 A \u578b\u8840\u53cb\u75c5\uff08Hemophilia A\uff09\u57fa\u56e0\u7597\u6cd5giroctocogene fitelparvovec\uff08SB-525 \u6216 PF-07055480\uff09\u7b2c\u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8c AFFINE\u00a0\u542f\u52a8\u3002\u8be5\u8bd5\u9a8c\u62db\u52df 60 \u4f4d\u4ee5\u4e0a\u7684\u6210\u5e74\uff08\u5e74\u9f84\u4e3a 18 \u81f3 64 \u5c81\uff09A \u578b\u8840\u53cb\u75c5\u4e2d\u5ea6\u4e25\u91cd\u81f3\u91cd\u5ea6\u7537\u6027\u60a3\u8005\u53d7\u8bd5\u8005\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0CAR-T\u7ec6\u80de\u836f\u7269\u83b7\u201c\u5b64\u513f\u836f\u201d\u79f0\u53f7<\/div>\n
10\u67085\u65e5\uff0c\u79d1\u6d4e\u751f\u7269\u533b\u836f\uff08\u4e0a\u6d77\uff09\u6709\u9650\u516c\u53f8\u5ba3\u5e03\uff0cFDA\u5df2\u6388\u4e88\u79d1\u6d4e\u751f\u7269\u9776\u5411Claudin18.2 \u81ea\u4f53\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u7ec6\u80de\uff08CLDN18.2 CAR-T\uff09\u201c\u5b64\u513f\u836f\u201d\u79f0\u53f7\u3002CLDN18.2 CAR-T\uff08CT041\uff09\u662f\u79d1\u6d4e\u751f\u7269\u5168\u7403\u9996\u521b\u7684\u5019\u9009\u836f\u7269\u4e4b\u4e00\uff0c\u7528\u4e8e\u6cbb\u7597CLDN18.2\u9633\u6027\u5b9e\u4f53\u80bf\u7624\u60a3\u8005\u3002CT041\u5df2\u88ab\u4e2d\u56fd\u836f\u76d1\u5c40\u548cFDA\u6279\u51c6\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u57fa\u77f3\u836f\u4e1a\u4e0e\u8f89\u745e\u8fbe\u6210\u6218\u7565\u5408\u4f5c<\/div>\n
9\u670830\u65e5\uff0c\u57fa\u77f3\u836f\u4e1a\u4e0e\u8f89\u745e\uff08Pfizer\uff09\u5b50\u516c\u53f8\u8f89\u745e\u6295\u8d44\u4ee5\u53ca\u8f89\u745e\u9999\u6e2f\u5ba3\u5e03\u5efa\u7acb\u6218\u7565\u5408\u4f5c\u5173\u7cfb\uff0c\u5305\u62ec\u8f89\u745e\u9999\u6e2f\u5bf9\u57fa\u77f3\u836f\u4e1a\u76842\u4ebf\u7f8e\u5143\u80a1\u6743\u6295\u8d44\uff0c\u8f89\u745e\u6295\u8d44\u4e0e\u57fa\u77f3\u836f\u4e1a\u8212\u683c\u5229\u5355\u6297\uff08CS1001\uff0cPD-L1\u6297\u4f53\uff09\u5728\u4e2d\u56fd\u5927\u9646\u5730\u533a\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\uff0c\u4ee5\u53ca\u5c06\u66f4\u591a\u80bf\u7624\u4ea7\u54c1\u5f15\u5165\u5927\u4e2d\u534e\u5730\u533a\u7684\u5408\u4f5c\u6846\u67b6\u3002<\/div>\n
\u00a0<\/div>\n
\u4f1a\u8bae<\/div>\n
\u2756\u00a02020\u4e2d\u56fd\u751f\u7269\u6280\u672f\u521b\u65b0\u5927\u4f1a<\/div>\n
\u7531\u4e2d\u56fd\u751f\u7269\u6280\u672f\u53d1\u5c55\u4e2d\u5fc3\u548c\u82cf\u5dde\u5e02\u4eba\u6c11\u653f\u5e9c\u5171\u540c\u4e3b\u529e\u3001\u82cf\u5dde\u5de5\u4e1a\u56ed\u533a\u7ba1\u7406\u59d4\u5458\u4f1a\u627f\u529e\uff0c2020\u4e2d\u56fd\u751f\u7269\u6280\u672f\u521b\u65b0\u5927\u4f1a\u62df\u5b9a\u4e8e11\u67082-4\u65e5\u5728\u82cf\u5dde\u4e3e\u529e\u3002\u5927\u4f1a\u5c06\u56f4\u7ed5\u65b0\u51a0\u80ba\u708e\u75ab\u60c5\u79d1\u7814\u653b\u5173\u3001\u521b\u65b0\u836f\u7269\u7814\u53d1\u4e0e\u4e34\u5e8a\u7814\u7a76\u3001\u521b\u65b0\u5408\u4f5c\u53ca\u8d44\u672c\u5e02\u573a\u3001\u521b\u65b0\u7ba1\u7406\u653f\u7b56\u6cd5\u89c4\u7b49\u5185\u5bb9\u5c55\u5f00\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a02020\u4e2d\u56fd\u7cbe\u51c6\u533b\u7597\u5927\u4f1a<\/div>\n
2020\u5e7410\u670830\u65e5-11\u67081\u65e5\uff0c\u7531\u5168\u56fd\u536b\u751f\u4ea7\u4e1a\u4f01\u4e1a\u7ba1\u7406\u534f\u4f1a\u7cbe\u51c6\u533b\u7597\u5206\u4f1a\u4e3b\u529e\u3001\u4e0a\u6d77\u7406\u5de5\u5927\u5b66\/\u6606\u5c71\u4e0a\u7406\u5de5\u5149\u7535\u4fe1\u606f\u5e94\u7528\u6280\u672f\u7814\u7a76\u9662\u6709\u9650\u516c\u53f8\u5171\u540c\u627f\u529e\u7684\u7b2c\u4e09\u5c4a\u4e2d\u56fd\u7cbe\u51c6\u533b\u7597\u5927\u4f1a\uff083rd CCPM\uff09\u5c06\u4e8e\u5728\u6c5f\u82cf\u7701\u6606\u5c71\u5e02\u53ec\u5f00\u3002\u672c\u5c4a\u5927\u4f1a\u4e3b\u9898\u4e3a\u201c\u7cbe\u51c6\u533b\u7597\u2014\u2014\u53d1\u73b0\u3001\u53d1\u660e\u3001\u53d1\u5c55\u201d\u3002<\/div>\n
\u00a0<\/div>\n
\u62d3\u5c55\u9605\u8bfb<\/div>\n
\u8bfa\u79be\u534e\u5927\u534e\u4e3a\u667a\u56e0\u7b49\u8054\u8882\u9996\u53d1\u57fa\u56e0\u5927\u6570\u636e<\/a>\u83b7\u8bfa\u5956\u7684\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u80cc\u540e\u5343\u4ebf\u7ea7\u4ea7\u4e1a\u903b\u8f91<\/a>\u57fa\u56e0\u5927\u6570\u636e\u884c\u7814\u62a5\u544a\u8282\u9009<\/a><\/div>\n
\u3010\u58f0\u660e\u3011\u4e3a\u4f20\u64ad\u79d1\u5b66\u4fe1\u606f\uff0c\u63a8\u52a8\u57fa\u56e0\u53ca\u6570\u5b57\u751f\u547d\u5065\u5eb7\u4ea7\u5b66\u7814\u8fde\u63a5\uff0c\u6211\u4eec\u79c9\u6301\u4e2d\u7acb\u3001\u4e13\u4e1a\u3001\u8d4b\u80fd\u7684\u7406\u5ff5\u6536\u96c6\u3001\u5206\u6790\u6216\u53d1\u5e03\u4fe1\u606f\u3002\u4f46\u7531\u4e8e\u65f6\u6548\u6027\u53ca\u884c\u4e1a\u7279\u6b8a\u6027\uff0c\u6240\u520a\u767b\u5185\u5bb9\u4ec5\u4f9b\u7814\u7a76\u53c2\u8003\uff0c\u4e0d\u4f5c\u4e3a\u51b3\u7b56\u4f9d\u636e\uff1b\u672c\u6587\u76f8\u5173\u4fe1\u606f\u4e0d\u4ee3\u8868\u57fa\u56e0\u6167\u673a\u6784\u7684\u89c2\u70b9\uff1b\u201c\u57fa\u56e0\u6167\u201d\u520a\u767b\u7684\u539f\u521b\u5185\u5bb9\u7684\u77e5\u8bc6\u4ea7\u6743\u4e3a\u201c\u57fa\u56e0\u6167\u201d\u5546\u6807\u62e5\u6709\u8005\u53ca\u76f8\u5173\u6743\u5229\u4eba\u6240\u6709\uff1b\u6b22\u8fce\u8f6c\u8f7d\uff0c\u8f6c\u8f7d\u8bf7\u7533\u8bf7\u5e76\u6ce8\u660e\u6765\u6e90\u3002\u6b22\u8fce\u4e2a\u4eba\u53ca\u673a\u6784\u6295\u7a3f\u53ca\u5408\u4f5c\u3002<\/div>\n
\u00a0<\/div>\n
\u5173\u4e8e\u57fa\u56e0\u6167\u00a0<\/div>\n
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\u2606\u00a0\u53c2\u4e0e\u7ec4\u7ec7\u53d1\u5e03\u884c\u4e1a\u5171\u8bc6<\/a>\u3001\u56e2\u4f53\u6807\u51c6<\/a><\/div>\n
\u2606\u00a0\u53d1\u5e03\u4ea7\u4e1a\u5927\u6570\u636e\u5e73\u53f0\u4f18\u8109\u901aYourMap<\/a><\/div>\n
\u2606\u00a0\u4e2d\u56fd\u9057\u4f20\u5b66\u4f1a\u751f\u7269\u4ea7\u4e1a\u4fc3\u8fdb\u59d4\u5458\u4f1a\u59d4\u5458<\/div>\n
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\u2606\u00a0\u7ec4\u7ec7\u57fa\u56e0\u68c0\u6d4b\u8054\u76df\uff08\u7b79\uff09\u9996\u5c4a<\/a>\u3001\u7b2c\u4e8c\u5c4a<\/a>\u4f1a\u8bae<\/a><\/div>\n
\u2606\u00a0\u4e3b\u529e\u6570\u5b57\u5065\u5eb7\u79c1\u8463\u4f1a<\/a>\u3001\u5927\u6e7e\u533a\u751f\u547d\u5065\u5eb7\u521b\u65b0\u8bba\u575b<\/a><\/div>\n
\u2606\u00a0\u53d7\u9080\u4e3a\u534e\u897f<\/a>\u3001Illumina<\/a>\u3001\u534e\u5927<\/a>\u3001\u4e0a\u6d77\u4ea4\u5927<\/a>\u7b49\u62a5\u544a<\/div>\n
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