{"id":9017,"date":"2020-10-19T02:24:49","date_gmt":"2020-10-18T18:24:49","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&mid=100016676&idx=1&sn=adc818b6826ee3910dda8853c73c440d&chksm=6b7170935c06f985fd380e6a3d9670b215c56ad2949f60250ffa5d88abcc6e1db932709b0266#rd"},"modified":"2026-04-01T17:06:51","modified_gmt":"2026-04-01T09:06:51","slug":"985598","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2020\/10\/19\/985598\/","title":{"rendered":"\u5468\u62a5\u4e28\u751f\u7269\u5236\u54c1\u96c6\u91c7\u65b0\u4fe1\u53f7\uff0c\u533b\u7597\u521b\u65b0\u4f01\u4e1a80\u5f3a\u699c\u5355\u516c\u5e03"},"content":{"rendered":"

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\u5934\u6761<\/div>\n
\u2756\u00a0\u56fd\u5bb6\u533b\u4fdd\u5c40\u79f0\u751f\u7269\u5236\u54c1\u6216\u5c06\u5f00\u5c55\u96c6\u91c7<\/div>\n
\u6d59\u6c5f\u7701\u65b0\u51a0\u96c6\u91c7\u5168\u56fd\u6700\u4f4e\u4ef7<\/div>\n
10\u67089\u65e5\uff0c\u56fd\u5bb6\u533b\u7597\u4fdd\u969c\u5c40\u5b98\u7f51\u516c\u5e03\u4e86\u5bf9\u5341\u4e09\u5c4a\u5168\u56fd\u4eba\u5927\u4e09\u6b21\u4f1a\u8bae\u7b2c 6450 \u53f7\u5efa\u8bae\u7684\u7b54\u590d\u3002\u5176\u4e2d\uff0c\u56fd\u5bb6\u533b\u4fdd\u5c40\u79f0\uff1a\u201c\u751f\u7269\u7c7b\u4f3c\u836f\u5e76\u975e\u96c6\u4e2d\u5e26\u91cf\u91c7\u8d2d\u7684\u7981\u533a\uff0c\u6b63\u5728\u7814\u7a76\u751f\u7269\u5236\u54c1\u96c6\u4e2d\u91c7\u8d2d\u76f8\u5173\u653f\u7b56\uff0c\u5728\u8003\u8651\u751f\u7269\u7c7b\u4f3c\u836f\u7684\u76f8\u4f3c\u6027\u3001\u4f01\u4e1a\u4ea7\u80fd\u548c\u4f9b\u5e94\u94fe\u7684\u7a33\u5b9a\u6027\u3001\u5177\u4f53\u4ea7\u54c1\u7684\u4e34\u5e8a\u53ef\u66ff\u4ee3\u6027\u7b49\u56e0\u7d20\u7684\u57fa\u7840\u4e0a\uff0c\u5c06\u9002\u65f6\u5f00\u5c55\u96c6\u4e2d\u5e26\u91cf\u91c7\u8d2d\u3002\u201d<\/div>\n
10\u670816\u65e5\uff0c\u6d59\u6c5f\u7701\u836f\u68b0\u91c7\u8d2d\u4e2d\u5fc3\u53d1\u5e03\u65b0\u51a0\u75c5\u6bd2\u68c0\u6d4b\u8bd5\u5242\u96c6\u4e2d\u91c7\u8d2d\u62df\u4e2d\u6807\u7ed3\u679c\u516c\u793a\u3002\u5176\u4e2d\uff0c\u65b0\u51a0\u75c5\u6bd2\u6838\u9178\u68c0\u6d4b\u8bd5\u5242\u6700\u4f4e\u62a5\u4ef78.88\u5143\uff0c\u65b0\u51a0\u6297\u4f53\u68c0\u6d4b\u8bd5\u5242\uff08IgG\/IgM\uff09\u6700\u4f4e\u62a5\u4ef79.8\u5143\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u521b\u4e1a\u90a6\u53d1\u5e03<\/div>\n
2020\u4e2d\u56fd\u533b\u7597\u5927\u5065\u5eb7\u521b\u65b0\u4f01\u4e1a80\u5f3a<\/div>\n
\u8fd1\u65e5\uff0c\u521b\u4e1a\u90a6\u901a\u8fc73\u4e2a\u591a\u6708\u7684\u8c03\u7814\u548c\u8bc4\u5ba1\uff0c\u5171\u9009\u51fa80\u5bb6\u533b\u7597\u5927\u5065\u5eb7\u4f01\u4e1a\uff0c\u6210\u4e3a\u672c\u5e74\u5ea6\u884c\u4e1a\u5185\u521b\u65b0\u4f01\u4e1a\u7684\u6807\u6746\u3002\u5176\u4e2d\u4e0a\u699c\u4f01\u4e1a\u5305\u62ec\u534e\u5927\u667a\u9020\u3001\u81fb\u548c\u79d1\u6280\u3001\u667a\u56e0\u4e1c\u65b9\u3001\u5fae\u8fdc\u57fa\u56e0\u3001\u91d1\u5319\u57fa\u56e0\u3001\u6c42\u81fb\u533b\u5b66\u3001\u9e4d\u8fdc\u57fa\u56e0\u3001\u6d77\u666e\u6d1b\u65af\u7b49\u3002\u6570\u636e\u663e\u793a\u5206\u5b50\u8bca\u65ad\u5e02\u573a\u9700\u6c42\u6fc0\u589e\uff0c\u521b\u65b0\u836f\u7814\u53d1\u52bf\u5934\u5f3a\u52b2\uff0c\u57fa\u56e0\u6cbb\u7597\u4e0e\u7ec6\u80de\u6cbb\u7597\u7b49\u751f\u7269\u836f\u9886\u57df\u5c24\u4e3a\u7a81\u51fa\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/www.cyzone.cn\/article\/605958.html<\/div>\n
\u00a0<\/div>\n
\u653f\u7b56<\/div>\n
\u2756\u00a0\u56fd\u52a1\u9662\u53d1\u5e03\u6df1\u5733\u7279\u8272\u5148\u884c\u793a\u8303\u533a\u5b9e\u65bd\u65b9\u6848<\/div>\n
\u5f00\u5c55\u65b0\u578b\u77e5\u8bc6\u4ea7\u6743\u6cd5\u5f8b\u4fdd\u62a4\u8bd5\u70b9<\/div>\n
10\u670811\u65e5\uff0c\u56fd\u52a1\u9662\u3001\u4e2d\u5171\u4e2d\u592e\u529e\u516c\u5385\u529e\u516c\u5385\u5370\u53d1\u4e86\u300a\u6df1\u5733\u5efa\u8bbe\u4e2d\u56fd\u7279\u8272\u793e\u4f1a\u4e3b\u4e49\u5148\u884c\u793a\u8303\u533a\u7efc\u5408\u6539\u9769\u8bd5\u70b9\u5b9e\u65bd\u65b9\u6848\uff082020\uff0d2025\u5e74\uff09\u300b\u3002\u65b9\u6848\u660e\u786e\uff0c\u6253\u9020\u4fdd\u62a4\u77e5\u8bc6\u4ea7\u6743\u6807\u6746\u57ce\u5e02\uff0c\u5f00\u5c55\u65b0\u578b\u77e5\u8bc6\u4ea7\u6743\u6cd5\u5f8b\u4fdd \u62a4\u8bd5\u70b9\uff0c\u5b8c\u5584\u4e92\u8054\u7f51\u4fe1\u606f\u7b49\u6570\u5b57\u77e5\u8bc6\u4ea7\u6743\u8d22\u4ea7\u6743\u76ca\u4fdd\u62a4\u5236\u5ea6\uff0c\u5efa\u7acb\u77e5\u8bc6\u4ea7\u6743\u4fb5\u6743\u60e9\u7f5a\u6027\u8d54\u507f\u5236\u5ea6\u3002<\/div>\n
\u00a0<\/div>\n
\u300a2021\u57fa\u56e0\u884c\u4e1a\u84dd\u76ae\u4e66\u300b<\/a><\/div>\n
\u00a0\u8054\u5408\u53d1\u5e03<\/a>\u542f\u52a8\u5408\u4f5c\u00a0<\/div>\n\n
\n
\"RmFicvQBAkgAlssHtUJibWMqEANnB1e2sKLxakxomlQy1YFhUPLjTOaqF8aTG8Cw5Vczkg1bfNaHt87Gib3sialbag\"\/<\/figure><\/div>\n\n
\u2756\u00a0\u4e2d\u56fd\u51fa\u53f0\u751f\u7269\u5b89\u5168\u6cd5<\/div>\n
10\u670817\u65e5\uff0c\u5341\u4e09\u5c4a\u5168\u56fd\u4eba\u5927\u5e38\u59d4\u4f1a\u7b2c\u4e8c\u5341\u4e8c\u6b21\u4f1a\u8bae\u8868\u51b3\u901a\u8fc7\u4e86\u751f\u7269\u5b89\u5168\u6cd5\u3002\u8fd9\u90e8\u6cd5\u5f8b\u81ea2021\u5e744\u670815\u65e5\u8d77\u65bd\u884c\uff0c\u8be5\u6cd5\u660e\u786e\u4e86\u751f\u7269\u5b89\u5168\u7684\u91cd\u8981\u5730\u4f4d\u548c\u539f\u5219\uff0c\u89c4\u5b9a\u751f\u7269\u5b89\u5168\u662f\u56fd\u5bb6\u5b89\u5168\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\u3002\u751f\u7269\u5b89\u5168\u6cd5\u5171\u8ba1\u5341\u7ae0\u516b\u5341\u516b\u6761\uff0c\u805a\u7126\u751f\u7269\u5b89\u5168\u9886\u57df\u4e3b\u8981\u98ce\u9669\uff0c\u5b8c\u5584\u751f\u7269\u5b89\u5168\u98ce\u9669\u9632\u63a7\u4f53\u5236\u673a\u5236\uff0c\u7740\u529b\u63d0\u9ad8\u56fd\u5bb6\u751f\u7269\u5b89\u5168\u6cbb\u7406\u80fd\u529b\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u52a9\u529b\u7ca4\u6e2f\u6fb3\u5927\u6e7e\u533a\u751f\u7269\u533b\u836f\u53d1\u5c55\u5e7f\u4e1c\u7701\u836f\u68c0\u6240\u836f\u7269\u5b89\u8bc4\u4e2d\u5fc3\u63ed\u724c<\/div>\n
\u8fd1\u65e5\uff0c\u5e7f\u4e1c\u7701\u836f\u54c1\u68c0\u9a8c\u6240\u836f\u7269\u5b89\u8bc4\u4e2d\u5fc3\uff08\u6bd2\u7406\u7814\u7a76\u4e2d\u5fc3\uff09\u6b63\u5f0f\u63ed\u724c\u3002\u7814\u7a76\u4e2d\u5fc3\u4e3b\u8981\u5f00\u5c55\u5305\u62ec\u836f\u54c1\u6ce8\u518c\u68c0\u9a8c\u3001\u836f\u54c1\u4e0a\u5e02\u524d\u8bc4\u4ef7\u7b49\u5b89\u5168\u8bc4\u4ef7\u5de5\u4f5c\uff0c\u540c\u65f6\uff0c\u81f4\u529b\u4e8e\u63d0\u5347\u836f\u54c1\u68c0\u9a8c\u68c0\u6d4b\u6280\u672f\u652f\u6491\u80fd\u529b\uff0c\u6253\u9020\u7ca4\u6e2f\u6fb3\u5927\u6e7e\u533a\u751f\u7269\u533b\u836f\u53d1\u5c55\u9ad8\u5730\uff0c\u529b\u4e89\u5efa\u8bbe\u4e3a\u56fd\u9645\u4e00\u6d41\u7684\u751f\u7269\u533b\u836f\u4ea7\u4e1a\u96c6\u805a\u533a\u3002<\/div>\n
\u00a0<\/div>\n
\u79d1\u7814<\/div>\n
\u2756Nature Reviews Genetics\u7efc\u8ff0\u6df1\u5ea6\u89e3\u6790\u80bf\u7624\u5f02\u8d28\u6027<\/div>\n
\u8fd1\u671f\uff0c\u82f1\u56fd\u7814\u7a76\u56e2\u961f\u5728Nature Reviews Genetics\u4e0a\u53d1\u8868\u4e86\u7efc\u8ff0\u6587\u7ae0Resolving genetic heterogeneity in cancer\uff0c\u4ece\u80bf\u7624\u8fdb\u5316\u3001\u6d4b\u5e8f\u624b\u6bb5\u3001\u67d3\u8272\u4f53\u4e0d\u7a33\u5b9a\u3001\u8fdb\u5316\u6a21\u5f0f\u4e0e\u60a3\u8005\u9884\u540e\u7b49\u591a\u4e2a\u89d2\u5ea6\u63a2\u8ba8\u4e86\u80bf\u7624\u5f02\u8d28\u6027\uff0c\u603b\u7ed3\u4e86\u4e8c\u4ee3\u6d4b\u5e8f\u5728\u63cf\u7ed8\u80bf\u7624\u8fdb\u5316\u8f68\u8ff9\u3001\u8f85\u52a9\u7cbe\u51c6\u6cbb\u7597\u7b49\u4e2d\u7684\u5e94\u7528\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/www.nature.com\/articles\/s41576-019-0114-6<\/div>\n
\u00a0<\/div>\n
\u2756\u57fa\u4e8e\u4f4e\u6df1\u5ea6WGS\u7684\u5c3f\u6db2\u764c\u75c7\u6db2\u4f53\u6d3b\u68c0\u65b0\u65b9\u6cd5\u654f\u611f\u6027\u53ca\u7279\u5f02\u6027\u8868\u73b0\u51fa\u8272<\/div>\n
\u8fd1\u65e5\uff0c\u957f\u6d77\u533b\u9662\u8bb8\u4f20\u4eae\u7b49\u56e2\u961f\u5408\u4f5c\u5f00\u53d1\u4e86\u4e00\u79cd\u540d\u4e3aUroCAD\u7684\u57fa\u4e8e\u5c3f\u6db2\u7684\u6db2\u4f53\u6d3b\u68c0\u65b9\u6cd5\uff0c\u8be5\u65b9\u6cd5\u53ef\u901a\u8fc7\u4f4e\u8986\u76d6\u7387\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u5206\u6790\u5c3f\u6db2\u8131\u843d\u7ec6\u80deDNA\u62f7\u8d1d\u6570\u53d8\u5f02\uff08CNV\uff09\u3002\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u5c3f\u6db2\u7ec6\u80de\u5b66\u68c0\u6d4b\u76f8\u6bd4\uff0cUroCAD\u68c0\u6d4b\u5c3f\u8def\u4e0a\u76ae\u764c\u5177\u6709\u66f4\u597d\u7684\u654f\u611f\u6027\u548c\u76f8\u4f3c\u7684\u7279\u5f02\u6027\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>DOI: 10.1158\/1078-0432.CCR-20-0401<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u8033\u804b\u7684\u81f4\u75c5\u673a\u5236\u7814\u7a76\u65b0\u89c6\u89d2\u7ebf\u7c92\u4f53\u8f6c\u5f55\u4e0d\u5bf9\u79f0\u526a\u5207\u7f3a\u9677<\/div>\n
10\u670812\u65e5\uff0c\u6d59\u6c5f\u5927\u5b66\u8bfe\u9898\u7ec4\u5728Nucleic Acids Research\u53d1\u8868\u4e86\u7ebf\u7c92\u4f53\u8f6c\u5f55\u540e\u4e0d\u5bf9\u79f0\u526a\u5207\u52a0\u5de5\u5bfc\u81f4\u6bcd\u7cfb\u9057\u4f20\u6027\u8033\u804b\u7684\u6700\u65b0\u7814\u7a76\u6210\u679c\uff0c\u8be5\u7814\u7a76\u4e3a\u7ebf\u7c92\u4f53\u57fa\u56e0\u7ec4\u8f6c\u5f55\u540e\u52a0\u5de5\u7f3a\u9677\u5f15\u8d77\u542c\u529b\u635f\u4f24\u7684\u673a\u5236\u63d0\u51fa\u4e86\u65b0\u89c1\u89e3\uff0c\u4e3a\u8033\u804b\u7684\u81f4\u75c5\u673a\u5236\u7814\u7a76\u63d0\u4f9b\u4e86\u65b0\u7684\u89c6\u89d2\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/academic.oup.com\/nar\/advance-article\/doi\/10.1093\/nar\/gkaa860\/5921305<\/div>\n
\u00a0<\/div>\n
\u4ea7\u4e1a<\/div>\n
\u2756\u00a06\u5bb6\u4f01\u4e1a\u878d\u8d44\u4fe1\u606f<\/div>\n\n
\n
\"RmFicvQBAkgAlssHtUJibWMqEANnB1e2sKtD6VL5jO4BfZr7WdJc8v4e58rY7wwtrthP4lTzhJTOeoX5wVoHCUcA\"\/<\/figure><\/div>\n\n
\u56fe\uff1a\u4f01\u4e1a\u878d\u8d44\u4fe1\u606f\uff08\u6765\u6e90\/\u57fa\u56e0\u6167\uff09<\/div>\n
\u8fd1\u671f\u56fd\u5185\u5916\u53d1\u5e03\u878d\u8d44\u52a8\u6001\u4f01\u4e1a\u5305\u62ec\u827a\u5999\u795e\u5dde\u3001\u827e\u5c14\u666e\u3001\u95ea\u91cf\u79d1\u6280\u3001\u535a\u96c5\u8f91\u56e0\u3001Ori Biotech\u3001Oxford Nanopore\u3002\u5176\u4e2d\uff0c\u57fa\u56e0\u7597\u6cd5\u516c\u53f8\u535a\u96c5\u8f91\u56e0\u5b8c\u62104.5\u4ebf\u5143B\u8f6e\u878d\u8d44\uff0c\u5373\u65f6\u5206\u5b50\u8bca\u65ad\u89e3\u51b3\u65b9\u6848\u4f01\u4e1a\u95ea\u91cf\u79d1\u6280\u8d85\u989d\u5b8c\u6210\u6570\u5343\u4e07\u5143\u4eba\u6c11\u5e01Pre-A\u8f6e\u878d\u8d44\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0Thermo Fisher 2020 \u5e74\u5ea6\u8d22\u52a1\u5206\u6790\u516c\u5e03\u9500\u552e\u989d<\/div>\n
\u8fd1\u65e5\uff0cThermo Fisher\u53ec\u5f00\u4e862020\u5e74\u5e74\u5ea6\u5206\u6790\u5927\u4f1a\u30022020\u5e74Thermo Fisher\u9500\u552e\u989d\u9884\u4f30\u8d85\u8fc7260\u4ebf\u7f8e\u5143\uff0c\u8fc7\u53bb10\u5e74\u5e74\u590d\u5408\u589e\u957f\u7387\u8fbe\u523011%\u3002\u5176\u4e1a\u52a1\u90e8\u95e8\u4e2d\uff0cLab Products & Services\u89c4\u6a21\u6700\u5927\uff0c\u5e74\u9500\u552e\u989d110\u4ebf\u7f8e\u5143\uff1bPharma & Biotech \u5bf9\u4e1a\u52a1\u7684\u8d21\u732e\u6bd4\u91cd\u6301\u7eed\u6269\u5927\uff0c\u4ece\u53bb\u5e74\u768439%\u6269\u5927\u81f342%\uff0c\u4e3b\u8981\u662f\u75ab\u60c5\u5e26\u6765\u7684\u6b63\u5411\u4e1a\u52a1\u673a\u4f1a\u6240\u81f4\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0Biogen\u4e0e\u8bfa\u5956\u5f97\u4e3b\u516c\u53f8\u8fbe\u6210\u57fa\u56e0\u6cbb\u7597\u5408\u4f5c<\/div>\n
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\u00a0<\/div>\n
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