{"id":9000,"date":"2020-11-03T15:00:11","date_gmt":"2020-11-03T07:00:11","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&#038;mid=100017247&#038;idx=1&#038;sn=52bb398945a05a5be4a208a40de8885d&#038;chksm=6b7176e85c06fffee73d96036b003efda08e4d0ae153466c1238c331338754480f3396e22958#rd"},"modified":"2026-04-08T09:38:41","modified_gmt":"2026-04-08T01:38:41","slug":"4910251","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2020\/11\/03\/4910251\/","title":{"rendered":"\u79d1\u7814\u4e28DNA\/RNA\u9776\u5411NGS\u52a9\u529b\u80bf\u7624\u539f\u53d1\u7076\u4e0d\u660e\u60a3\u8005\u4e34\u5e8a\u6cbb\u7597"},"content":{"rendered":"<p><!-- wechat_content_hash: 1f3b184ba99a5dea --><\/p>\n<div>\u3010\u5bfc\u8bed\u3011\u539f\u53d1\u7076\u4e0d\u660e\u80bf\u7624\u901a\u5e38\u9884\u540e\u4e0d\u826f\uff0c\u5176\u8bca\u65ad\u4e0e\u63a7\u5236\u5728\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u81f3\u5173\u91cd\u8981\u3002\u8fd1\u65e5\uff0c\u65e5\u672c\u7814\u7a76\u56e2\u961f\u53d1\u73b0\u5229\u7528RNA\u6d4b\u5e8f\u7684\u7ec4\u7ec7\u6eaf\u6e90\u7ed3\u679c\uff0c\u540c\u65f6\u7ed3\u5408DNA\u6d4b\u5e8f\u8fdb\u884c\u9776\u5411\u6cbb\u7597\uff0c\u80fd\u7ed9\u80bf\u7624\u539f\u53d1\u7076\u4e0d\u660e\uff08CUP\uff09\u60a3\u8005\u5e26\u6765\u66f4\u591a\u4e34\u5e8a\u83b7\u76ca\u3002<\/div>\n<div>\u6587\u7ae0 | \u5143\u7801\u533b\u5b66\u7f16\u8f91 | \u7f57\u6e58\u00a0 \u5173\u952e\u8bcd |\u00a0NGS \u80bf\u7624<\/div>\n<div>\u00a0<\/div>\n<div>\u539f\u53d1\u90e8\u4f4d\u4e0d\u660e\u80bf\u7624\uff08CUP\uff09\u8bca\u6cbb\u96be<\/div>\n<div>\u73b0\u4ee3\u764c\u75c7\u8bca\u7597\u4f53\u7cfb\u4e2d\uff0c\u660e\u786e\u80bf\u7624\u539f\u53d1\u90e8\u4f4d\u662f\u8fdb\u884c\u6807\u51c6\u5316\u6cbb\u7597\u7684\u57fa\u7840\u3002\u65e0\u6cd5\u627e\u5230\u60a3\u8005\u7684\u539f\u53d1\u75c5\u7076\u4f1a\u5927\u5927\u589e\u52a0\u6cbb\u7597\u96be\u5ea6\u3002\u539f\u53d1\u90e8\u4f4d\u4e0d\u660e\u80bf\u7624\uff08Cancer of unknown primary,CUP\uff09\u662f\u4e00\u7c7b\u76f8\u5bf9\u7f55\u89c1\u7684\u80bf\u7624\uff0c\u5373\u5728\u4f53\u5185\u53d1\u73b0\u4e86\u6076\u6027\u80bf\u7624\u7ec6\u80de\uff0c\u4f46\u5374\u65e0\u6cd5\u786e\u5b9a\u80bf\u7624\u7684\u539f\u53d1\u90e8\u4f4d[1]\u3002\u5927\u591a\u6570CUP\u60a3\u8005\u7531\u4e8e\u539f\u53d1\u7076\u4e0d\u660e\u786e\uff0c\u901a\u5e38\u53ea\u80fd\u63a5\u53d7\u7ecf\u9a8c\u6027\u5316\u7597\uff0c\u9884\u540e\u8f83\u5dee\uff0c\u751f\u5b58\u65f6\u95f4\u8f83\u77ed\uff0c\u4e2d\u4f4d\u603b\u751f\u5b58\u671f (OS) \u53ea\u67096\u81f312\u4e2a\u6708[2]\u3002\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>\u79d1\u5b66\u7814\u7a76\u53d1\u73b0\uff0c\u8f6c\u79fb\u7076\u80bf\u7624\u7684\u57fa\u56e0\u8868\u8fbe\u8c31\u4e0e\u5176\u539f\u53d1\u90e8\u4f4d\u7ec4\u7ec7\u7684\u57fa\u56e0\u8868\u8fbe\u8c31\u76f8\u4f3c\uff0c\u800c\u4e0e\u8f6c\u79fb\u90e8\u4f4d\u76f8\u5dee\u751a\u8fdc\u3002\u56e0\u6b64\uff0c\u5206\u6790\u57fa\u56e0\u8868\u8fbe\u8c31\u53ef\u7528\u4e8e\u9274\u522b\u539f\u53d1\u7076\u4e0d\u660e\u8f6c\u79fb\u764c\u7684\u539f\u53d1\u90e8\u4f4d[3]\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u968f\u7740\u4e8c\u4ee3\u6d4b\u5e8f\u6280\u672f\u7684\u98de\u901f\u53d1\u5c55\uff0c\u57fa\u4e8eNGS\u7684\u9776\u5411\u6cbb\u7597\u5e7f\u6cdb\u8fd0\u7528\u4e8e\u4e34\u5e8a\u3002\u901a\u8fc7RNA\u6d4b\u5e8f\uff0c\u5206\u6790\u57fa\u56e0\u8868\u8fbe\u8c31\u4e5f\u5df2\u7ecf\u88ab\u7528\u6765\u786e\u5b9aCUP\u7684\u539f\u53d1\u90e8\u4f4d\u3002\u90a3\u4e48\u5229\u7528 RNA\u6d4b\u5e8f\u7684\u7ec4\u7ec7\u6eaf\u6e90\u7ed3\u679c\u540c\u65f6\u7ed3\u5408DNA\u6d4b\u5e8f\u8fdb\u884c\u9776\u5411\u6cbb\u7597\u662f\u5426\u80fd\u7ed9CUP\u60a3\u8005\u5e26\u6765\u66f4\u591a\u4e34\u5e8a\u83b7\u76ca\uff1f<\/div>\n<div>\u00a0<\/div>\n<div>NGS\u6539\u5584CUP\u60a3\u8005\u7597\u6548<\/div>\n<div>\u8fd1\u65e5\uff0c\u53d1\u8868\u5728JAMA Oncology\u4e0a\u7684\u4e00\u7bc7\u8bba\u6587\u63ed\u793a\u4e86\u7b54\u6848\u3002\u65e5\u672c\u7814\u7a76\u56e2\u961f\u9488\u5bf9\u8fd9\u4e2a\u95ee\u9898\u53d1\u8d77\u4e86\u4e00\u9879\u524d\u77bb\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u975e\u968f\u673a\u7684\u4e34\u5e8aII\u671f\u7814\u7a76\uff0c\u7ed3\u679c\u8868\u660e\uff0c\u9488\u5bf9\u7ec4\u7ec7\u6eaf\u6e90\u548cDNA\u53d8\u5f02\u7ed3\u679c\u8fdb\u884c\u5206\u5b50\u9776\u5411\u6cbb\u7597\u6539\u5584\u4e86CUP\u60a3\u8005\u7684\u4e34\u5e8a\u6cbb\u7597\u6548\u679c[4]\u3002\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>\u7814\u7a76\u8005\u4eec\u5171\u8054\u540819\u4e2a\u4e2d\u5fc3\uff0c\u57282015\u5e743\u6708\u81f32018\u5e741\u6708\u671f\u95f4\uff0c\u62db\u52df\u4e86111\u540dCUP\u60a3\u8005\uff0c\u901a\u8fc7NGS\u68c0\u6d4b\u60a3\u8005\u7684\u57fa\u56e0\u8868\u8fbe\u6a21\u5f0f\u548c\u57fa\u56e0\u7a81\u53d8\u72b6\u51b5\uff0c\u6784\u5efa\u7b97\u6cd5\uff0c\u9884\u6d4b\u51fa15\u4e2a\u80bf\u7624\u539f\u53d1\u90e8\u4f4d\uff0c\u6700\u540e\u670997\u4f4d\u60a3\u8005\u91c7\u53d6\u76f8\u5e94\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/1MiceChERt3cknL61XWTrK1Z2SicW9qrrTYHGrUtLGLTrHHqHY3icqH8YLL4Be9sOPlscWjPV7V8aApL3CXY5et5A\/640?wx_fmt=jpeg\" alt=\"640?wx_fmt=jpeg\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe1A\uff1a\u5168\u90e8\u60a3\u8005\u7684OS \u00a0\u00a0 \u00a0\u56fe1B\uff1a\u5168\u90e8\u60a3\u8005\u7684PFS<\/div>\n<div>\u6cbb\u7597\u7ed3\u679c\u663e\u793a\uff0c\u4e0a\u8ff0\u60a3\u8005\u7684\u4e00\u5e74\u751f\u5b58\u7387\u3001\u4e2d\u4f4dOS\u548c\u4e2d\u4f4dPFS\uff08\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff09\u5206\u522b\u4e3a53.1% (95% CI\uff0c42.6%-62.5%)\u300113.7\u4e2a\u6708(95% CI\uff0c9.3-19.7\u4e2a\u6708)\u548c5.2\u4e2a\u6708(95% CI\uff0c3.3-7.1\u4e2a\u6708)\uff08\u56fe1A\u548cB\uff09\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/1MiceChERt3cknL61XWTrK1Z2SicW9qrrTbb4brFb8lqPsIIqOIsI5YoCeSKcortB3m10h8cjL66gAQ0koaDsrkA.jpeg\" alt=\"1MiceChERt3cknL61XWTrK1Z2SicW9qrrTbb4brFb8lqPsIIqOIsI5YoCeSKcortB3m10h8cjL66gAQ0koaDsrkA\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u88681\uff1a\u539f\u53d1\u90e8\u4f4d\u9884\u6d4b\u7ed3\u679c<\/div>\n<div>\u5176\u4e2d\u6700\u5e38\u88ab\u9884\u6d4b\u5230\u7684\u764c\u79cd\u662f\u80ba\u764c(21 [21.6%])\u3001\u809d\u764c(15 [15.5%])\u3001\u80be\u764c(15[15.5%])\u3001\u7ed3\u76f4\u80a0\u764c(12 [12.4%])\uff08\u88681\uff09\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u9884\u6d4b\u51fa\u6765\u768415\u79cd\u764c\u79cd\u53ef\u4ee5\u5206\u4e3a\u5bf9\u6cbb\u7597\u9ad8\u5e94\u7b54\uff08more responsive\uff09\u548c\u4f4e\u5e94\u7b54\uff08less responsive\uff09\u4e24\u4e2a\u4e9a\u7ec4\u3002\u524d\u8005\u5305\u62ec\u5927\u80a0\u764c\u3001\u4e73\u817a\u764c\u3001\u5375\u5de2\u764c\u3001\u80be\u764c\u3001\u524d\u5217\u817a\u764c\u3001\u8180\u80f1\u764c\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c, \u751f\u6b96\u7ec6\u80de\u764c\u548c\u6dcb\u5df4\u7624\uff0c\u540e\u8005\u5305\u62ec\u80c6\u7ba1\u764c\u3001\u80f0\u817a\u764c\u3001\u80c3\u98df\u7ba1\u764c\u3001\u809d\u764c\u3001\u5bab\u9888\u764c\u3001\u5b50\u5bab\u5185\u819c\u764c\u548c\u5934\u9888\u90e8\u80bf\u7624\u300268\u4f8b\u60a3\u8005(70.1%)\u7684\u9884\u6d4b\u7ed3\u679c\u4e3a\u9ad8\u5e94\u7b54\u764c\u79cd\uff0c29\u4f8b\u5219\u5c5e\u4e8e\u4f4e\u5e94\u7b54\u764c\u79cd\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/1MiceChERt3cknL61XWTrK1Z2SicW9qrrTYHGrUtLGLTrHHqHY3icqH8YLL4Be9sOPlscWjPV7V8aApL3CXY5et5A\/640?wx_fmt=jpeg\" alt=\"640?wx_fmt=jpeg\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe1C\uff1a\u9ad8\u5e94\u7b54\u548c\u4f4e\u5e94\u7b54\u60a3\u8005\u7684OS<\/div>\n<div style=\"text-align: center;\">\u56fe1D\uff1a\u9ad8\u5e94\u7b54\u548c\u4f4e\u5e94\u7b54\u60a3\u8005\u7684PFS<\/div>\n<div>\u4ece\u6cbb\u7597\u7ed3\u679c\u4e0a\u770b\uff0c\u9ad8\u5e94\u7b54\u764c\u79cd\u4e2d\u4f4dOS\u4e3a15.7\u4e2a\u6708(95% CI, 10.0-21.9\u4e2a\u6708)\uff0c \u4e2d\u4f4dPFS\u4e3a5.5\u4e2a\u6708(95% CI, 4.1-8.6\u4e2a\u6708)\uff0c\u800c\u4f4e\u5e94\u7b54\u764c\u79cd\u4e2d\u4f4dOS\u4e3a11.0\u4e2a\u6708(95% CI, 4.0-21.2\u4e2a\u6708)\uff0c\u4e2d\u4f4dPFS\u4e3a2.8\u4e2a\u6708(95% CI, 1.8 -5.9\u4e2a\u6708)\uff08\u56fe1C\u548cD\uff09\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u4eceDNA\u53d8\u5f02\u53d1\u751f\u7684\u57fa\u56e0\u4e0a\u770b\uff0cTP53 (45 [46.4%])\u3001KRAS (19 [19.6%])\u548cCDKN2A (18 [18.6%])\u53d1\u751f\u9891\u7387\u6700\u9ad8\u3002\u00a0<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/mmbiz.qlogo.cn\/mmbiz_jpg\/1MiceChERt3cknL61XWTrK1Z2SicW9qrrTqRL7JW5lryqPUjho9enBSjOqNJXaWuViaqib200IC8vnKeOSv5oArwNA\/0?wx_fmt=jpeg\" alt=\"0?wx_fmt=jpeg\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe2 A\uff1a\u5168\u90e8\u60a3\u8005\u57fa\u56e0\u53d8\u5f02\u7684\u7c7b\u578b\u548c\u6570\u91cf<\/div>\n<div>1\u5e74\u751f\u5b58\u7387\u3001\u4e2d\u4f4dOS\u548c\u4e2d\u4f4dPFS\u5206\u522b\u4e3a53.1% (95% CI\uff0c42.6%-62.5%)\u300113.7\u4e2a\u6708(95% CI\uff0c9.3-19.7\u4e2a\u6708)\u548c5.2\u4e2a\u6708(95% CI\uff0c3.3-7.1\u4e2a\u6708)\uff08\u56fe2A\uff09\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/1MiceChERt3cknL61XWTrK1Z2SicW9qrrTqRL7JW5lryqPUjho9enBSjOqNJXaWuViaqib200IC8vnKeOSv5oArwNA\/0?wx_fmt=jpeg\" alt=\"0?wx_fmt=jpeg\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe2B\uff1a\u975e\u5c0f\u7ec6\u80de\u60a3\u8005\u63a5\u53d7\u963f\u6cd5\u66ff\u5c3c\u6cbb\u7597\u540e\u7684PFS<\/div>\n<div>\u57285\u4f8b\u9884\u6d4b\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005(5.2%)\u7684\u80bf\u7624\u6807\u672c\u4e2d\u68c0\u6d4b\u5230\u9776\u5411EGFR\u7a81\u53d8\uff0c\u5176\u4e2d4\u4f8b\u63a5\u53d7\u4e86\u963f\u6cd5\u66ff\u5c3c\u6cbb\u7597\uff1b\u5176\u4e2d2\u4f8b\u60a3\u8005\u7684PFS\u6301\u7eed\u65f6\u95f4\u8d85\u8fc76\u4e2a\u6708\uff08\u56fe2B\uff09\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/1MiceChERt3cknL61XWTrK1Z2SicW9qrrTqRL7JW5lryqPUjho9enBSjOqNJXaWuViaqib200IC8vnKeOSv5oArwNA\/0?wx_fmt=jpeg\" alt=\"0?wx_fmt=jpeg\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe2C\uff1a\u5305\u542bKRAS\u7a81\u53d8\u7684\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u63a5\u53d7\u76f8\u5e94\u6cbb\u7597\u540e\u7684PFS<\/div>\n<div>\u5728\u9884\u6d4b\u4e3a\u7ed3\u76f4\u80a0\u764c\u7684\u60a3\u8005\u4e2d\uff0c\u670910\u4e2a\u5305\u542bKRAS\u7a81\u53d8\u3002\u8fd9\u4e9b\u60a3\u8005\u90fd\u672a\u91c7\u7528\u6297EGFR\u6297\u4f53\u6cbb\u7597\uff0c\u800c\u662f\u63a5\u53d7\u5316\u7597\u8054\u5408\u6297\u8840\u7ba1\u751f\u6210\u836f\u7269\u6cbb\u7597\uff0c\u6536\u5230\u8f83\u597d\u7684\u7597\u6548\uff08\u56fe2C\uff09\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u8be5\u7814\u7a76\u662f\u7b2c\u4e00\u4e2a\u901a\u8fc7NGS\u6280\u672f\u5206\u6790RNA\u8868\u8fbe\u6a21\u5f0f\uff0c\u786e\u5b9aCUP\u60a3\u8005\u7684\u539f\u53d1\u90e8\u4f4d\uff0c\u5e76\u7ed3\u5408\u5176DNA\u53d8\u5f02\u91c7\u53d6\u76f8\u5e94\u6cbb\u7597\u7684\u524d\u77bb\u6027\u8bd5\u9a8c\u3002\u7ed3\u679c\u8868\u660e\uff0c\u60a3\u8005\u4e2d\u4f4dOS\u4e3a13.7\u4e2a\u6708\uff0c\u8f83\u539f\u6765\u7684OS\uff086-12\u4e2a\u6708\uff09\u6709\u4e00\u5b9a\u63d0\u9ad8\u3002\u8d85\u8fc7\u534a\u6570\u60a3\u8005\u63a5\u53d7\u4e86\u5305\u62ec\u5206\u5b50\u9776\u5411\u6cbb\u7597\u7684\u540e\u7eed\u6cbb\u7597\uff0c\u53ef\u80fd\u5bfc\u81f4\u4e86\u8f83\u957f\u7684OS\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u7814\u7a76\u8fd8\u5c06\u8fd9\u90e8\u5206CUP\u60a3\u8005\u8fdb\u4e00\u6b65\u533a\u5206\u4e3a\u9ad8\u5e94\u7b54\u548c\u4f4e\u5e94\u7b54\u4e24\u4e2a\u4e9a\u7ec4\uff0c\u524d\u8005\u6709\u66f4\u957f\u7684OS\u548cPFS\uff0c\u6709\u5229\u4e8e\u60a3\u8005\u7684\u5206\u5c42\u6cbb\u7597\u3002<\/div>\n<div>\u5c3d\u7ba1\u5f53\u524d\u6709\u4e00\u4e9b\u6cdb\u764c\u79cd\u836f\u7269\u88ab\u6279\u51c6\u7528\u4e8e\u7279\u5b9a\u7684\u57fa\u56e0\u53d8\u5f02\uff08\u5982NTRK\u6291\u5236\u5242\uff09[5]\uff0c\u4f46\u5728\u591a\u6570\u60c5\u51b5\u4e0b\u660e\u786e\u80bf\u7624\u7684\u539f\u53d1\u90e8\u4f4d\u4f9d\u7136\u662f\u91c7\u53d6\u6b63\u786e\u6cbb\u7597\u7684\u524d\u63d0\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u4ec5\u51ed\u57fa\u56e0\u53d8\u5f02\u5e76\u4e0d\u8db3\u4ee5\u6307\u5bfcCUP\u60a3\u8005\u7684\u6709\u6548\u6cbb\u7597\uff0c\u4f8b\u5982BRAF\u6291\u5236\u5242\u7ef4\u83ab\u975e\u5c3c\u5bf9\u5305\u542bBRAF\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u8102\u8d28\u8089\u82bd\u80bf\u75c5\u548c\u6717\u683c\u6c49\u65af\u7ec6\u80de\u7ec4\u7ec7\u7ec6\u80de\u589e\u591a\u75c7\u6709\u8f83\u597d\u7597\u6548\uff0c\u4f46\u5bf9\u5305\u542b\u540c\u6837\u7a81\u53d8\u7684\u5176\u4ed6\u80bf\u7624\u7c7b\u578b\uff08\u4e73\u817a\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u5375\u5de2\u764c\u548c\u80c6\u7ba1\u764c\uff09\u5747\u672a\u89c2\u5bdf\u5230\u663e\u8457\u7597\u6548[6]\uff0c\u7531\u6b64\u53ef\u89c1\u660e\u786eCUP\u60a3\u8005\u7684\u539f\u53d1\u90e8\u4f4d\u5728\u80bf\u7624\u6cbb\u7597\u4e2d\u7684\u91cd\u8981\u6027\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u5143\u7801\u57fa\u56e0\u7ec4\u7ec7\u6eaf\u6e90\u4ea7\u54c1<\/div>\n<div>\u5143\u7801\u57fa\u56e0\u901a\u8fc7NGS\u6280\u672f\u5168\u9762\u5206\u6790\u68c0\u6d4b\u57fa\u56e0\u8868\u8fbe\u8c31\u548cDNA\u53d8\u5f02\uff0c\u5229\u7528\u81ea\u6709\u667a\u80fd\u7b97\u6cd5\uff0c\u9884\u6d4b\u80bf\u7624\u539f\u53d1\u90e8\u4f4d\u3002\u5176\u76f8\u5173\u80bf\u7624\u6eaf\u6e90\u4ea7\u54c1\u5df2\u8fd0\u884c\u4e00\u5e74\u6709\u4f59\uff0c\u4e3a\u591a\u4f4dCUP\u60a3\u8005\u51c6\u786e\u9884\u6d4b\u80bf\u7624\u539f\u53d1\u7076\uff0c\u7ed9\u60a3\u8005\u5e26\u6765\u8bf8\u591a\u4e34\u5e8a\u83b7\u76ca\u3002\u76ee\u524d\u5df2\u53d1\u8868\u591a\u7bc7\u9ad8\u8d28\u91cf\u7814\u7a76\u8bba\u6587\uff0c\u4e13\u5229\u5df2\u83b7\u6388\u6743\uff0c\u671f\u5f85\u66f4\u591a\u4e34\u5e8a\u5408\u4f5c\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/1MiceChERt3f9GD6qubKz584AM9bVr5zbVic04bkRXragsiaXE6ojQk3eHVDWvyjGnM3I8Dhy9tfRBFcU8P7Hosag.jpeg\" alt=\"1MiceChERt3f9GD6qubKz584AM9bVr5zbVic04bkRXragsiaXE6ojQk3eHVDWvyjGnM3I8Dhy9tfRBFcU8P7Hosag\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe\uff1a\u539f\u53d1\u7076\u7ec4\u7ec7\u6eaf\u6e90\u65b9\u6cd5\u6d41\u7a0b\u56fe<\/div>\n<div>\u5143\u7801\u57fa\u56e0\u63a8\u51fa\u7684\u539f\u53d1\u7076\u4e0d\u660e\u80bf\u7624\u7ec4\u7ec7\u6eaf\u6e90\u68c0\u6d4b\u4ea7\u54c1\uff0c\u5229\u7528RNA-seq\u6280\u672f\u68c0\u6d4b\u8868\u8fbe\u8c31\uff0c\u6784\u5efa\u968f\u673a\u68ee\u6797\u7b97\u6cd5\uff0c\u76ee\u524d\u53ef\u51c6\u786e\u8ffd\u6eaf16\u79cd\u764c\u75c7\u7c7b\u578b\uff08\u80ba\u817a\u764c\u3001\u80ba\u9cde\u764c\u3001\u4e73\u817a\u764c\u3001\u80c3\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u80f0\u817a\u764c\u3001\u809d\u7ec6\u80de\u764c\u3001\u524d\u5217\u817a\u764c\u3001\u7532\u72b6\u817a\u764c\u3001\u5375\u5de2\u764c\u3001\u5bab\u9888\u764c\u3001\u5b50\u5bab\u5185\u819c\u764c\u3001\u5934\u9888\u90e8\u9cde\u764c\u3001\u8111\u80f6\u8d28\u7624\u3001\u8180\u80f1\u764c\u3001\u80be\u7ec6\u80de\u764c\uff09\uff0c53\u79cd\u4e9a\u578b\uff1b\u80fd\u591f\u534f\u52a9\u533b\u751f\u627e\u5230\u80bf\u7624\u7684\u7ec4\u7ec7\u8d77\u6e90\uff0c\u7ed3\u5408\u5176\u4ed6\u533b\u5b66\u4fe1\u606f\uff0c\u5236\u5b9a\u6700\u4f73\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u4e3a\u60a3\u8005\u4e89\u53d6\u6700\u5927\u7684\u751f\u5b58\u83b7\u76ca\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u53c2\u8003\u8d44\u6599<\/div>\n<div>[1].Pavlidis, N. and G. Pentheroudakis, Cancer of unknown primary site. Lancet, 2012. 379(9824): p. 1428-35.<\/div>\n<div>[2].Petrakis, D., et al., Prognostication in cancer of unknown primary (CUP): development of a prognostic algorithm in 311 cases and review of the literature. Cancer Treat Rev, 2013. 39(7): p. 701-8.<\/div>\n<div>[3].Horlings, H.M., et al., Gene expression profiling to identify the histogenetic origin of metastatic adenocarcinomas of unknown primary. J Clin Oncol, 2008. 26(27): p. 4435-41.<\/div>\n<div>[4].Hayashi, H., et al., Site-Specific and Targeted Therapy Based on Molecular Profiling by Next-Generation Sequencing for Cancer of Unknown Primary Site: A Nonrandomized Phase 2 Clinical Trial. JAMA Oncol, 2020.<\/div>\n<div>[5].Drilon, A., et al., Safety and Antitumor Activity of the Multitargeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1). Cancer Discov, 2017. 7(4): p. 400-409.<\/div>\n<div>[6].Hyman, D.M., et al., Vemurafenib in Multiple Nonmelanoma Cancers with BRAF V600 Mutations. N Engl J Med, 2015. 373(8): p. 726-36.<\/div>\n<div>\u00a0<\/div>\n<div>\u00a0\u5173\u4e8e\u5143\u7801\u57fa\u56e0\u00a0<\/div>\n<div>\u5143\u7801\u57fa\u56e0\u662f\u4e00\u5bb6\u96c6\u7cbe\u51c6\u533b\u7597\u65b0\u6280\u672f\u7814\u53d1\u3001\u4ea7\u54c1\u8f6c\u5316\u548c\u57fa\u56e0\u68c0\u6d4b\u670d\u52a1\u4e3a\u4e00\u4f53\u7684\u9ad8\u65b0\u6280\u672f\u4f01\u4e1a\u3002\u516c\u53f8\u81ea2014\u5e74\u6210\u7acb\u4ee5\u6765\uff0c\u81f4\u529b\u4e8e\u5c06\u5148\u8fdb\u7814\u7a76\u6210\u679c\u4e0e\u6280\u672f\u5e94\u7528\u4e8e\u4e34\u5e8a\u5b9e\u8df5\uff0c\u76ee\u524d\u5df2\u7533\u8bf7\u4e13\u522939\u4f59\u9879\uff0c\u8f6f\u4ef6\u8457\u4f5c\u674338\u9879\u3002\u5143\u7801\u533b\u5b66\u68c0\u9a8c\u5b9e\u9a8c\u5ba4\uff0c\u7531\u56fd\u5bb6\u536b\u8ba1\u59d4\u6279\u590d\u6210\u7acb\uff0c\u5e76\u53d6\u5f97\u533b\u7597\u673a\u6784\u6267\u4e1a\u8bb8\u53ef\u8bc1\uff0c\u5728\u536b\u8ba1\u59d4\u4e3e\u884c\u7684\u5386\u6b21\u5ba4\u95f4\u8d28\u8bc4\u4e2d\u5747\u4ee5\u6ee1\u5206\u901a\u8fc7\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u516c\u53f8\u4f9d\u6258\u5b8c\u6574\u7684\u6280\u672f\u5e73\u53f0\uff0c\u5728\u80bf\u7624\u9886\u57df\u63a8\u51fa\u7cfb\u5217\u4ea7\u54c1\u7ebf\uff0c\u6db5\u76d6\u80bf\u7624\u65e9\u7b5b\u65e9\u8bca\u3001\u7cbe\u51c6\u7528\u836f\u548c\u5b9e\u65f6\u76d1\u63a7\u7684\u5168\u7a0b\u7ba1\u7406\uff0c\u6700\u5927\u9650\u5ea6\u5730\u6ee1\u8db3\u4e0d\u540c\u9636\u6bb5\u80bf\u7624\u60a3\u8005\u7684\u9700\u6c42\u3002\u5143\u7801\u57fa\u56e0\u5c06\u7ee7\u7eed\u4ee5\u66f4\u6743\u5a01\u7684\u68c0\u6d4b\u6280\u672f\u3001\u66f4\u4f18\u8d28\u7684\u68c0\u6d4b\u670d\u52a1\u4e3a\u6bcf\u4e00\u4f4d\u7528\u6237\u7684\u5065\u5eb7\u4fdd\u9a7e\u62a4\u822a\uff0c\u4e3a\u5b9e\u73b0\u57fa\u56e0\u79d1\u6280\u9020\u798f\u4eba\u7c7b\u4f5c\u4e3a\u76ee\u6807\u800c\u4e0d\u61c8\u52aa\u529b\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u63a8\u8350\u9605\u8bfb<\/div>\n<div><a 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