{"id":8986,"date":"2020-11-20T00:32:41","date_gmt":"2020-11-19T16:32:41","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&mid=100017499&idx=1&sn=ec54d2efaa9f6ca8ac846510026b3006&chksm=6b7177ec5c06fefa9dba74db3ac0bfa08e0d2695d06b371dc762d53bfe2eb375439f0824fe75#rd"},"modified":"2026-04-08T09:37:15","modified_gmt":"2026-04-08T01:37:15","slug":"484855","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2020\/11\/20\/484855\/","title":{"rendered":"\u5f71\u54cd\u672a\u676510\u5e74\u7684\u9ed1\u79d1\u6280\uff1aDNA\u6570\u636e\u5b58\u50a8\u5438\u5f15\u5fae\u8f6f\u3001Illumina\u7b4915\u5bb6\u7ed3\u76df"},"content":{"rendered":"

<\/p>\n

5G\u548c\u91cf\u5b50\u8ba1\u7b97\u7b49\u8ba1\u7b97\u6280\u672f\u5feb\u901f\u53d1\u5c55\u540c\u65f6\uff0c\u6709\u4e00\u4e2a\u95ee\u9898\u65e5\u76ca\u4e25\u91cd\uff0c\u52302040\u5e74\u6570\u636e\u5b58\u50a8\u53ef\u80fd\u4e0d\u591f\u7528\u4e86\u2014\u2014\u4e9f\u9700\u4fe1\u606f\u5bc6\u5ea6\u66f4\u9ad8\u7684\u5b58\u50a8\u4ecb\u8d28\uff0c\u4f8b\u5982\u6bd4\u786c\u76d8\u5b58\u50a8\u4fe1\u606f\u5bc6\u5ea6\u9ad8\u6548\u4e00\u767e\u4e07\u500d\u7684DNA\uff0c\u8fd9\u5438\u5f15\u5230\u5fae\u8f6f\u8054\u5408Illumina\u7b4915\u5bb6\u673a\u6784\u572811\u6708\u6210\u7acbDNA\u6570\u636e\u5b58\u50a8\u8054\u76df\u3002DNA\u6570\u636e\u5b58\u50a8\uff0c\u8fd9\u9879\u9ed1\u79d1\u6280\u5df2\u7ecf\u88ab\u7814\u7a76\u4e8650\u591a\u5e74\uff0c\u8fd1\u5e74\u5f97\u5230\u52a0\u901f\uff0c\u5c06\u5f71\u54cd\u672a\u676510\u5e74\u7684IT\u548cBT\u683c\u5c40\u3002<\/div>\n
\u00a0<\/div>\n
\u6587\u7ae0 | \u57fa\u56e0\u6167\u7f16\u8f91 | Barney\u00a0 \u5173\u952e\u8bcd | DNA\u6570\u636e\u5b58\u50a8<\/div>\n\n
\n
\"RmFicvQBAkgAwcVKvZ6BPHjHyVLZD7bMrSMRLHIEmHv0TKJd7ZzdzBe3ibf5fdbEXbKQwlibh2wjRLUrIOzrHjehQ\"\/<\/figure><\/div>\n\n
\u56fe1\uff08\u6765\u6e90\/YOSHI SODEOKA\uff09<\/div>\n
2011\u5e742\u670816\u65e5\uff0c\u4e00\u4e2a\u7565\u663e\u9634\u6c89\u7684\u661f\u671f\u4e09\uff0c\u5728\u5fb7\u56fd\u6c49\u5821\u5e02\u7684\u4e00\u5bb6\u65c5\u9986\u9152\u5427\u91cc\uff0c\u6765\u81ea\u6b27\u6d32\u751f\u7269\u4fe1\u606f\u7814\u7a76\u6240\u7684Nick Goldman\u4e0e\u4ed6\u7684\u670b\u53cb\u6b63\u5728\u4e3a\u4e00\u4e2a\u95ee\u9898\u8ba8\u8bba\u5f97\u9762\u7ea2\u8033\u8d64\uff0c\u7ed3\u675f\u540e\uff0c\u5927\u5bb6\u90fd\u611f\u5230\u975e\u5e38\u6cae\u4e27\u3002\u662f\u4ec0\u4e48\u95ee\u9898\u5462\uff1f<\/div>\n
\u00a0<\/div>\n
\u5982\u4f55\u8d1f\u62c5\u8d77\u5728\u4e16\u754c\u5404\u5730\u7684\u6d77\u91cf\u57fa\u56e0\u7ec4\u6570\u636e\u6602\u8d35\u7684\u5b58\u50a8\uff1f\u800c\u4e14\uff0c\u5b58\u50a8\u53ef\u80fd\u5f88\u5feb\u5c31\u4e0d\u591f\u7528\u4e86\u3002<\/div>\n
Goldman\u8bb0\u5f97\u90a3\u5929\uff0c\u4ed6\u4eec\u751a\u81f3\u5f00\u59cb\u5bf9\u201c\u79d1\u5e7b\u7684\u66ff\u4ee3\u54c1\u201dDNA\u5f00\u8d77\u5f00\u73a9\u7b11\uff1a\u4e3a\u4ec0\u4e48\u6211\u4eec\u4e0d\u7528DNA\u6765\u5b58\u50a8DNA\u4fe1\u606f\u5462\uff1f<\/div>\n
\u8fd9\u5728\u5f53\u65f6\u53ea\u662f\u4e00\u4e2a\u73a9\u7b11\u8bdd\uff0c\u540e\u6765\u5c31\u4e0d\u53ea\u662f\u73a9\u7b11\uff0c\u800c\u662f\u2014\u2014\u79d1\u5e7b\u7167\u8fdb\u73b0\u5b9e\u3002<\/div>\n
\u00a0<\/div>\n
\u5927\u6570\u636e\u5b58\u50a8\u5373\u5c06\u4e0d\u591f\u7528\u4e86<\/div>\n
\u968f\u7740\u4e92\u8054\u7f51\u4ee5\u53ca5G\u7b49\u6280\u672f\u7684\u53d1\u5c55\uff0c\u5168\u740337\u4ebf\u4e92\u8054\u7f51\u7528\u6237\u6bcf\u5929\u4ea7\u751f\u7ea6\u6570\u4ebfGB\u7ea7\u6570\u636e\u3002\u6839\u636eNature\u62a5\u9053\uff0c2020\u5e74\uff0c\u5168\u7403\u6570\u5b57\u4fe1\u606f\u5bb9\u91cf\u4f30\u8ba1\u5c06\u8fbe\u523044\u4e07\u4ebfGB\uff0c\u662f2013\u5e74\u768410\u500d\uff1b\u52302040\u5e74\uff0c\u5982\u679c\u6240\u6709\u5185\u5bb9\u90fd\u5b9e\u73b0\u5373\u65f6\u8bbf\u95ee\uff0c\u5b58\u50a8\uff08\u57fa\u4e8e\u95ea\u5b58\uff09\u5c06\u6d88\u8017\u7684\u5fae\u82af\u7247\u7ea7\u7845\u662f\u9884\u671f\u4f9b\u5e94\u91cf\u768410\u2013100\u500d\u3002<\/div>\n\n
\n
\"RmFicvQBAkgAwcVKvZ6BPHjHyVLZD7bMrIQDI6e0pyP0YCsoS1Vmv0ibfxaeX9aicv7c50oJ27ESicMWFt2icYBpUng\"\/<\/figure><\/div>\n\n
\u56fe2\uff1a\u6570\u636e\u5b58\u50a8\u7684\u80fd\u529b\u8fdc\u8fdc\u8d76\u4e0d\u4e0a\u6570\u636e\u751f\u4ea7\u7684\u901f\u5ea6<\/div>\n
\uff08\u6765\u6e90\/Twist, IDC\uff09<\/div>\n
\u56e0\u4e3a\u7845\u5b58\u50a8\u4fe1\u606f\u7684\u5bc6\u5ea6\u6709\u9650\uff0c\u4e5f\u5c31\u4e0d\u96be\u7406\u89e3\u4e3a\u4ec0\u4e48\u76ee\u524d\u6570\u636e\u7684\u6c38\u4e45\u6027\u5b58\u50a8\u8fd8\u662f\u7528\u8001\u5f0f\u7684\u78c1\u5e26\u3002\u867d\u7136\u78c1\u5e26\u5b58\u50a8\u7684\u4fe1\u606f\u5bc6\u5ea6\u6bd4\u786c\u76d8\u5927\u5f88\u591a\uff0c\u4f46\u6709\u53e6\u5916\u4e24\u4e2a\u95ee\u9898\uff1a\u8bfb\u8d77\u6765\u975e\u5e38\u6162\uff0c\u800c\u4e14\u7279\u522b\u8017\u7535\u3002<\/div>\n
\u00a0<\/div>\n
\u7f8e\u56fd\u8ba1\u7b97\u795e\u7ecf\u79d1\u5b66\u5bb6David Markowitz\u8868\u793a\uff0c\u4e00\u4e2aEB\uff08\u767e\u4e07GB\uff09\u7ea7\u522b\u6570\u636e\u4e2d\u5fc3\u5982\u679c\u4f7f\u7528\u78c1\u5e26\uff0c\u6bcf\u5e74\u7684\u5efa\u8bbe\u548c\u7ef4\u62a4\u8d39\u7528\u5c06\u9700\u89811\u4ebf\u7f8e\u5143\uff0c\u4ee5\u53ca\u8017\u7535\u5343\u4e07\u5ea6\u7ea7\u522b\uff0c\u56e0\u6b64\u78c1\u5e26\u5b58\u50a8\u4e0d\u53ef\u6301\u7eed\u3002<\/div>\n
\u00a0<\/div>\n
\u90a3\u4e48\uff0c\u6570\u636e\u5b58\u50a8\u7684\u672a\u6765\u5c06\u662f\u4ec0\u4e48\uff1f\u89e3\u51b3\u65b9\u6848\u662fDNA\u6570\u636e\u5b58\u50a8\u3002<\/div>\n
\u4ece\u7269\u7406\u5c42\u9762\uff0cDNA\u662f\u5b87\u5b99\u4e2d\u4fe1\u606f\u5bc6\u5ea6\u6700\u9ad8\u7684\u5df2\u77e5\u5b58\u50a8\u4ecb\u8d28\uff0c\u4fe1\u606f\u5bc6\u5ea6\u662f\u786c\u76d8\u7684\u4e00\u767e\u4e07\u500d\uff0c\u662f\u95ea\u5b58\u7684\u4e00\u5343\u500d\uff0c\u5355\u4f4d\u8017\u7535\u91cf\u4ec5\u4e3a\u4ebf\u5206\u4e4b\u4e00\u3002\u6b64\u5916\uff0c\u7531\u4e8eDNA\u7684\u7a33\u5b9a\u6027\uff0c\u76ee\u524d\u4ece70\u4e07\u5e74\u524d\u7684\u53e4DNA\uff082013\u5e74\uff0c\u9a6c\u57fa\u56e0\u7ec4\uff09\u4e2d\u4ecd\u53ef\u8fdb\u884c\u6d4b\u5e8f\u89e3\u8bfb\uff0c\u5176\u5b58\u50a8\u65f6\u6548\u8fdc\u975e\u5176\u4ed6\u4ecb\u8d28\u53ef\u6bd4\u62df\u3002<\/div>\n\n
\n
\"RmFicvQBAkgAwcVKvZ6BPHjHyVLZD7bMrHn44Xwr9ric6gT86DpmejMcg4DBxhRhlqAKUDQDX8iam5nOVPYqstmuA\"\/<\/figure><\/div>\n\n
\u56fe3\uff1a\u5b58\u50a8\u4ecb\u8d28\u7684\u5bf9\u6bd4<\/div>\n
\uff08\u6765\u6e90\/doi:10.1038\/537022a\uff09<\/div>\n
David Markowitz\u8ba4\u4e3a\uff0c\u5982\u679c\u7528DNA\u6765\u5b58\u50a8\u6570\u636e\uff0c\u5168\u4e16\u754c\u7684\u5b58\u50a8\u9700\u6c42\u75281\u5343\u514b\u7684DNA\u5c31\u53ef\u4ee5\u6ee1\u8db3\uff08\u4fe1\u606f\u5c01\u88c5\u5bc6\u5ea6\u4ee5\u5927\u80a0\u6746\u83cc\u7684\u57fa\u56e0\u4e3a\u6807\u51c6\uff09\u3002<\/div>\n
\u00a0<\/div>\n
\u4e1a\u5185\u9996\u4efd\u84dd\u76ae\u4e66\u300a2021\u57fa\u56e0\u884c\u4e1a\u84dd\u76ae\u4e66\u300b<\/a><\/div>\n
\u00a0\u201c\u8054\u5408\u53d1\u5e03\u201c<\/a>\u62db\u52df\u5373\u5c06\u622a\u6b62<\/div>\n\n
\n
\"RmFicvQBAkgAqgLND3ibSG4373MhzaaMVbKCiaa2KH0tDCYkBt95zeUIVFcWHXDfOSAPRFgwkiamY4RhHtaF87aGzg\"\/<\/figure><\/div>\n\n

<\/a><\/div>\n

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64\u5e74\u524d\u5c31\u5f00\u59cb\u7684DNA\u6570\u636e\u5b58\u50a8\u7814\u7a76<\/div>\n
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\"RmFicvQBAkgAqgLND3ibSG4373MhzaaMVbSkqOuoRziagqIVyTSdSvk0rG0oMXhiaFMCaCoibbo50B6sLMPUBpibplAw\"\/<\/figure><\/div>\n\n
\u56fe4\uff1aDNA\u6570\u636e\u5b58\u50a8\u7814\u7a76\u7684\u4e3b\u8981\u6587\u732e\u53d1\u5e03\u65f6\u95f4\u8868<\/div>\n
\uff08\u6765\u6e90\/doi:10.1038\/s41576-019-0125-3)<\/div>\n
DNA\u6570\u636e\u5b58\u50a8\u7684\u6982\u5ff5\u53ef\u4ee5\u8ffd\u6eaf\u52301960\u5e74\u4ee3\u4e2d\u671f\u3002\u5f53\u65f6\uff0c\u79d1\u5b66\u5bb6Norbert Wiener\u548cMikhail Neiman\u9996\u6b21\u53d1\u8868\u4e86\u6709\u5173\u201c\u9057\u4f20\u5185\u5b58\uff08genetic memory\uff09\u201d\u7684\u6982\u5ff5\u3002\u4f46\u5f53\u65f6DNA\u6d4b\u5e8f\u548c\u5408\u6210\u6280\u672f\u4ecd\u5904\u4e8e\u8d77\u6b65\u9636\u6bb5\u3002\u76f4\u523020\u591a\u5e74\u540e\uff0cDNA\u6570\u636e\u5b58\u50a8\u7684\u6982\u5ff5\u624d\u6b63\u5f0f\u5f97\u4ee5\u88ab\u77e5\u6653\u3002<\/div>\n
\u00a0<\/div>\n
1988\u5e74\uff0c\u827a\u672f\u5bb6Joe Davis\u4e0e\u54c8\u4f5b\u5927\u5b66\u7814\u7a76\u4eba\u5458\u5408\u4f5c\uff0c\u9996\u6b21\u5c06\u6570\u5b571\u548c0\u6620\u5c04\u5230DNA\u7684\u56db\u4e2a\u78b1\u57fa\u4e0a\uff0c\u5e76\u63d2\u5165\u5927\u80a0\u6746\u83cc\u7684DNA\u5e8f\u5217\uff0c\u4ec5\u7f16\u780135\u4f4d\uff08bits\uff09\u3002\u5927\u7ea6\u5728\u540c\u4e00\u65f6\u95f4\u76841986\u5e74\uff0cRichard Dawkins\u5728\u4e66\u7c4d\u300a\u76f2\u4eba\u949f\u8868\u5320\u300b \u4e2d\u4e5f\u63d0\u5230\u4e86\u8fd9\u4e00\u60f3\u6cd5\u3002<\/div>\n
\u00a0<\/div>\n
\u540e\u6765Joe Davis\u52a0\u5165\u4e86\u54c8\u4f5b\u5927\u5b66\u77e5\u540d\u9057\u4f20\u5b66\u5bb6George Church\u7684\u5b9e\u9a8c\u5ba4\uff0c\u57282011\u5e74\u5c06DNA\u6570\u636e\u5b58\u50a8\u7684\u6982\u5ff5\u5f15\u5165\u4e16\u754c\uff1a\u628a\u4e00\u672c52,000\u5b57\u7684\u4e66\u7f16\u7801\u5230\u6570\u5343\u4e2aDNA\u7247\u6bb5\u4e2d\u3002\u5408\u4f5c\u8005\u5305\u62ec\u52a0\u5229\u798f\u5c3c\u4e9a\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\u7684Sri Kosuri\u548c\u4f4d\u4e8e\u7ea6\u7ff0\u00b7\u970d\u666e\u91d1\u65af\u5927\u5b66\u7684Yuan Gao\u3002<\/div>\n\n
\n
\"RmFicvQBAkgAwcVKvZ6BPHjHyVLZD7bMrq7whmewKWbY6BGvLR3icv9jiaYZna3gITCvrkDzf6IukES9caeBDOSQQ\"\/<\/figure><\/div>\n\n
\u56fe5\uff1a\u534e\u76db\u987f\u5927\u5b66\u548c\u5fae\u8f6f\u8fdb\u884cDNA\u6570\u636e\u5b58\u50a8\u81ea\u52a8\u5316\u7684\u6982\u5ff5\u9a8c\u8bc1\u7684\u88c5\u7f6e\u53ca\u539f\u7406\uff08\u6765\u6e90\/Valuewalk\uff09<\/div>\n
\u4e0e\u6b64\u540c\u65f6\uff0cEBI\uff08\u6b27\u6d32\u751f\u7269\u4fe1\u606f\u7814\u7a76\u6240\uff09\u7684Nick Goldman\u548cEwan Birney\u57282011\u5e74\u5fb7\u56fd\u6c49\u5821\u5e02\u7684\u9152\u5427\u9910\u5dfe\u7eb8\u4e0a\u8ba8\u8bba\u5b8c\u540e\uff0c\u628aDNA\u6570\u636e\u5b58\u50a8\u7684\u60f3\u6cd5\u5e26\u5230\u4e86\u5b9e\u9a8c\u5ba4\uff0c\u4e24\u5e74\u540e\u5ba3\u5e03\u6210\u529f\u5730\u4f7f\u7528DNA\u7f16\u7801\u4e86\u4e94\u4e2a\u6587\u4ef6\uff0c\u5bb9\u91cf739 KB\uff0c\u662f\u6709\u53f2\u4ee5\u6765\u6700\u5927\u7684DNA\u6863\u6848\uff1b\u76f4\u52302016\u5e747\u6708\uff0c\u5fae\u8f6f\u548c\u534e\u76db\u987f\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u58f0\u79f0\u5df2\u8dc3\u5347\u81f3200 MB\uff08\u5176\u4e2d\u5305\u62ec\u97f3\u4e50\u548c\u89c6\u9891\uff09\u3002<\/div>\n
\u00a0<\/div>\n
\u600e\u4e48\u7528DNA\u6765\u5b58\u50a8\u6570\u636e\uff1f<\/div>\n
DNA\u5230\u5e95\u600e\u4e48\u5b58\u50a8\u6570\u636e\u5462\uff1f\u5173\u952e\u6b65\u9aa4\u6709\u4e24\u4e2a\uff1a\u7f16\u7801\u548c\u89e3\u7801\u3002<\/div>\n\n
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\"RmFicvQBAkgAwcVKvZ6BPHjHyVLZD7bMrVRUmfMgibJ5n2T5H3L1EvmgmVXdhmx9gAjLicvb5RlibHKYVib22aicic6Ww\"\/<\/figure><\/div>\n\n
\u56fe6\uff1a\u901a\u8fc7DNA\u5408\u6210\u5b58\u50a8DNA\u57fa\u7840\u903b\u8f91<\/div>\n
DNA\u901a\u8fc7\u5bc6\u7801\u5b50\u5408\u6210\u6c28\u57fa\u9178\uff0c\u4fe1\u606f\u901a\u8fc7\u4e8c\u8fdb\u5236\u8f6c\u5316\u4e3a\u78b1\u57fa\uff08\u6765\u6e90\/digitaltrends\uff09<\/div>\n
\u00a0<\/div>\n
\u5148\u8bf4\u7f16\u7801\u3002<\/div>\n
\u5728\u8ba1\u7b97\u673a\u4e2d\uff0c\u4efb\u4f55\u4fe1\u606f\u4ee51\u548c0\u7684\u5f62\u5f0f\u5b58\u50a8\u3002\u800c\u5728DNA\u4e2d\uff0c\u9057\u4f20\u4fe1\u606f\uff08\u901a\u5e38\uff09\u4ee5\u56db\u79cd\u78b1\u57fa\u817a\u560c\u5464(A)\u3001\u80f8\u817a\u5627\u5576(T)\u3001\u80de\u5627\u5576(C)\u548c\u9e1f\u560c\u5464(G)\u4e14\u6309\u89c4\u5219\u5728\u751f\u7269\u4f53\u5185\u6392\u5e8f\u3002\u5c060\u548c1\u4ee5\u4e0d\u540c\u89c4\u5219\uff08\u89c1\u4e0b\u56fe\uff09\u6620\u5c04A\/T\/C\/G\uff0c\u5373\u53ef\u5f62\u6210\u5e8f\u5217\u5b58\u50a8\u5230DNA\u4e2d\u3002<\/div>\n\n
\n
\"RmFicvQBAkgAwcVKvZ6BPHjHyVLZD7bMr3h1WR3cVJyFHCXQk9NezecQpyOp0ybGG8W4xhkLSV9eYGptwkFEv6Q\"\/<\/figure><\/div>\n\n
\u56fe7\uff1aDNA\u6570\u636e\u5b58\u50a8\u4f7f\u7528\u7684\u56db\u79cd\u8f6c\u7801\u65b9\u6cd5\u4e3e\u4f8b<\/div>\n
\uff08\u6765\u6e90\/doi: 10.1093\/gigascience\/giz075\uff09<\/div>\n
\u518d\u8bf4\u89e3\u7801\u3002<\/div>\n
DNA\u901a\u8fc7PCR\u6269\u589e\uff08\u4f53\u5916\uff09\uff0c\u53ef\u4ee5\u6309\u7167\u5bc6\u7801\u5b50\u8868\u89c4\u5219\uff08\u4e09\u4e2a\u76f8\u90bb\u78b1\u57fa\u7f16\u7801\u4e00\u4e2a\u6c28\u57fa\u9178\uff09\u7ffb\u8bd1\u6210\u86cb\u767d\u8d28\uff08\u4f53\u5185\uff09\uff0c\u56e0\u6b64\u53ef\u5b58\u50a8\u5728\u4f53\u5185\u6216\u4f53\u5916\u5e76\u8fdb\u884c\u590d\u5236\uff08\u4ea7\u751f\u62f7\u8d1d\uff09\u3002\u5982\u679c\u5728\u751f\u7269\u4f53\u5185\uff0c\u901a\u8fc7\u57fa\u56e0\u6d4b\u5e8f\u5373\u53ef\u4ece\u751f\u7269\u7ec4\u7ec7\u6216\u4f53\u6db2\u4e2d\u8bfb\u53d6DNA\u5e8f\u5217\u4fe1\u606f\uff0c\u518d\u901a\u8fc7\u539f\u59cb\u6620\u5c04\u89c4\u5219\u89e3\u7801\u51fa\u539f\u59cb\u5b58\u50a8\u7684\u5b57\u8282\u4fe1\u606f\u3002<\/div>\n
\u5177\u4f53\u600e\u4e48\u64cd\u4f5c\uff1f<\/div>\n\n
\n
\"RmFicvQBAkgAwcVKvZ6BPHjHyVLZD7bMr1z43MR8icZHMPve7mnib3fibl3JN7Ia7R1TicSILMuorWJOiaETZkKrpA5g\"\/<\/figure><\/div>\n\n<\/div>\n
<\/div>\n
\n\n
\n
\"640?wx_fmt=png\"\/<\/figure><\/div>\n\n
\u56fe8\uff1aDNA\u6570\u636e\u5b58\u50a8\u548c\u89e3\u8bfb\u7684\u6d41\u7a0b<\/div>\n
\uff08\u6765\u6e90\/Twist\u7b49\uff09<\/div>\n
\u9996\u5148\uff0c\u91c7\u7528\u8ba1\u7b97\u673a\u7b97\u6cd5\u5c06\u4fe1\u606f\u5b57\u8282\u8f6c\u6362\u6210\u4e3aDNA\u5e8f\u5217\uff1b\u7136\u540e\u673a\u5668\u5408\u6210DNA\u5e8f\u5217\uff08\u7f16\u5199\uff09\uff0c \u4ea7\u751f\u6bcf\u4e2a\u5e8f\u5217\u7684\u591a\u4e2a\u7269\u7406\u62f7\u8d1d\u3002\u4ee5\u78f7\u9170\u80fa\u4e3a\u57fa\u7840\u7684\u56fa\u76f8\u67f1\u4e0a\u5408\u6210\uff08\u4f4e\u901a\u91cf\uff09\u6216\u56fa\u76f8\u4ecb\u8d28\u4e0a\u9635\u5217\u5408\u6210\uff08\u9ad8\u901a\u91cf\uff09\u3002\u5408\u6210\u540e\u7684\u7684 DNA \u6750\u6599\u53ef\u4ee5\u514b\u9686\u5e76\u5b58\u50a8\u5728\u751f\u7269\u7ec6\u80de\u5185\uff08\u4f53\u5185\uff09\u6216\u8005\u4f53\u5916\uff08\u66f4\u5e38\u89c1\uff09\u3002<\/div>\n
\u00a0<\/div>\n
\u5176\u6b21\uff0c\u901a\u8fc7\u68c0\u7d22\u9009\u62e9\u76ee\u6807DNA\u518d\u4f7f\u7528\u6620\u5c04\u5230\u7f16\u7801\u8fc7\u7a0b\u4e2d\u6240\u751f\u6210\u7279\u5b9a\u6570\u636e\u9879\u7684\u5f15\u7269\u548cPCR\u6269\u589e\uff0c\u83b7\u5f97\u76ee\u6807DNA\uff0c\u518d\u901a\u8fc7\u6d4b\u5e8f\u4eea\u83b7\u53d6DNA\u5bf9\u5e94\u7684\u5e8f\u5217\u3002<\/div>\n
\u6700\u540e\uff0c\u901a\u8fc7\u6620\u5c04\u89c4\u5219\u5c06\u5e8f\u5217\u8f6c\u7801\u6210\u539f\u59cb\u76840\u548c1\u5b57\u8282\u4fe1\u606f\u3002<\/div>\n
\u00a0<\/div>\n
DNA\u6570\u636e\u5b58\u50a8\u7684\u96be\u70b9\u548c\u7a81\u7834<\/div>\n
\u76ee\u524d\uff0cDNA\u6570\u636e\u5b58\u50a8\u5904\u4e8e\u5b9e\u9a8c\u7814\u7a76\u9636\u6bb5\u3002\u5728\u6210\u719f\u4e4b\u524d\u9762\u4e34\u4ee5\u4e0b\u51e0\u4e2a\u4e3b\u8981\u7684\u95ee\u9898\u3002<\/div>\n\n
\n
\"RmFicvQBAkgAwcVKvZ6BPHjHyVLZD7bMrTI84vvgaiccIaicrQPdm7iaPntNqrrkqYVvWArAMKbichqviaSaz7f9GhlA\"\/<\/figure><\/div>\n\n
\u56fe9\uff1aDNA\u6570\u636e\u5b58\u50a8\u8fc7\u7a0b\u8be6\u89e3<\/div>\n
\uff08\u6765\u6e90\/doi:10.1038\/s41467-019-10978-4\uff09<\/div>\n
\u9996\u5148\uff0c\u8981\u786e\u4fdd\u4fe1\u606f\u4e0d\u5931\u771f\u3002<\/div>\n
\u4e25\u683c\u610f\u4e49\u4e0a\uff0cDNA\u6570\u636e\u5b58\u50a8\u6ca1\u6709\u7ea0\u9519\u529f\u80fd\uff0c\u9700\u8981\u4f9d\u9760\u6bcf\u4e2a\u5e8f\u5217\u591a\u4e2a\u526f\u672c\uff08\u62f7\u8d1d\uff09\u6240\u63d0\u4f9b\u7684\u5197\u4f59\u4fe1\u606f\u6765\u6821\u6b63\u3002<\/div>\n
\u00a0<\/div>\n
\u57282011\u5e74\uff0cGeorge Church\u548cGao Yuan\u5408\u4f5c\u7684659KB DNA\u6570\u636e\u5b58\u50a8\u4e2d\uff0c\u5728\u5e8f\u5217\u6392\u5e8f\u540e\u53d1\u73b0\u4e8622\u4e2a\u9519\u8bef\u3002\u800c\u5728\u540c\u65f6\u671f\uff0c\u6b27\u6d32\u751f\u7269\u4fe1\u606f\u7814\u7a76\u6240\u786e\u4fdd\u6bcf25\u4e2a\u78b1\u57fa\u7247\u6bb5\u90fd\u6709\u56db\u4e2a\u7248\u672c\u7684\u60c5\u51b5\u4e0b\uff0c\u4ecd\u7136\u572825\u4e2a\u78b1\u57fa\u5e8f\u5217\u4e2d\u53d1\u73b0\u4e862\u4e2a\u9519\u8bef\u3002<\/div>\n
\u00a0<\/div>\n
\u4e3a\u63d0\u9ad8\u51c6\u786e\u7387\uff0c2017\u5e747\u6708\uff0cGeorge Church\u56e2\u961f\u91c7\u7528CRISPR \u7f16\u8f91\u6280\u672f\u5c06\u4eba\u7c7b\u624b\u7684\u56fe\u50cf\u8bb0\u5f55\u5230\u5927\u80a0\u6746\u83cc\u57fa\u56e0\u7ec4\u4e2d\uff0c\u5e76\u4ee590\uff05\u4ee5\u4e0a\u7684\u51c6\u786e\u7387\u8bfb\u53d6\u4e86\u8be5\u56fe\u50cf\u3002<\/div>\n
\u00a0<\/div>\n
\u5176\u6b21\uff0c\u8981\u5b9e\u73b0\u5feb\u901f\u8bfb\u53d6\u3002<\/div>\n
\u4f7f\u7528\u6807\u51c6\u6d4b\u5e8f\u65b9\u6cd5\uff0c\u68c0\u6d4b\u4efb\u4f55\u4e00\u6761\u6570\u636e\u65f6\u90fd\u9700\u8981\u8bfb\u53d6\u6bcf\u4e2aDNA\u5b57\u7b26\u4e32\uff0c\u76f8\u6bd4\u4f20\u7edf\u8ba1\u7b97\u673a\u5b58\u50a8\u53ef\u4ee5\u968f\u673a\u8bbf\u95ee\uff0c\u663e\u5f97\u7b28\u91cd\u5730\u591a\u3002<\/div>\n
\u00a0<\/div>\n
\u9488\u5bf9\u8fd9\u4e2a\u95ee\u9898\uff0c2017\u5e743\u6708\uff0c\u79d1\u5b66\u5bb6\u521b\u9020\u4e86\u4e00\u79cd\u79f0\u4e3a\u201dDNA\u55b7\u6cc9\u201c\u7684\u7b97\u6cd5\uff0c\u53ef\u4ee5\u4ece\u7279\u5b9a\u5bc6\u5ea6\uff08\u6bcf\u514bDNA\u5b58\u50a8215 PB\uff09\u76f8\u5bf9\u5b8c\u7f8e\u5730\u68c0\u7d22\u4fe1\u606f\u3002\u800cCatalog\u516c\u53f8\u7684\u65b9\u6cd5\u662f\u5c06\u6570\u636e\u8f6c\u6362\u4e3a\u5408\u6210\u805a\u5408\u7269\u7684\u56fa\u4f53\u9897\u7c92\u3002\u8bbf\u95ee\u6570\u636e\u65f6\uff0c\u5c06\u5176\u6c89\u6dc0\u548c\u518d\u6c34\u5316\uff08rehydrate\uff09\uff0c\u4f46\u8fd9\u4e2a\u8fc7\u7a0b\u4ecd\u7136\u9700\u8981\u81f3\u5c11\u51e0\u4e2a\u5c0f\u65f6\u3002<\/div>\n
\u00a0<\/div>\n
\u518d\u8005\uff0c\u964d\u4f4e\u6210\u672c\u63d0\u9ad8\u53ef\u53ca\u6027\u3002<\/div>\n
DNA\u6570\u636e\u5b58\u50a8\u7684\u4f20\u7edf\u601d\u8def\u662f\u4f9d\u8d56\u4e8e\u6bcf\u6b21\u5408\u6210\u65b0\u7684DNA\u5206\u5b50\uff0c\u7136\u540e\u5c06\u5b57\u8282\u5e8f\u5217\u6620\u5c04\u5230DNA\u7684\u78b1\u57fa\u5bf9\u5e8f\u5217\u3002\u8fd9\u9700\u8981\u5236\u9020\u8db3\u591f\u7684DNA\u5206\u5b50\u6765\u5b58\u50a8\u60f3\u8981\u7684\u4fe1\u606f\uff0c\u8fc7\u7a0b\u7a0b\u7f13\u6162\u4e14\u6602\u8d35\u3002<\/div>\n
\u5728\u4e0a\u8ff0EBI\u7684\u8bd5\u9a8c\u4e2d\uff0c\u82b1\u8d3912,660\u7f8e\u5143\uff0c\u5176\u4e2d98%\u662f\u5408\u6210DNA\u7684\u6210\u672c\u3002<\/div>\n
\u00a0<\/div>\n
\u4e3a\u6539\u5584\u8fd9\u4e2a\u95ee\u9898\uff0cCatalog\u516c\u53f8\u7684\u65b9\u6cd5\u662f\u5c06\u5408\u6210\u8fc7\u7a0b\u4e0e\u7f16\u7801\u8fc7\u7a0b\u5206\u79bb\u3002\u5373\uff0c\u53ea\u751f\u6210\u5927\u91cf\u7684\u51e0\u4e2a\u201c\u9884\u5236\u5206\u5b50\u201d\uff08\u4f7f\u5176\u4fbf\u5b9c\u5f97\u591a\uff09\uff0c\u7136\u540e\u901a\u8fc7\u4ece\u9884\u5236\u5206\u5b50\u4e2d\u4ea7\u751f\u5927\u91cf\u591a\u6837\u6027\u6765\u7f16\u7801\u4fe1\u606f\u3002\u7c7b\u6bd4\u786c\u76d8\u5b58\u50a8\u7684\u8bdd\uff0c\u76f8\u5f53\u5927\u91cf\u751f\u4ea7\u7a7a\u767d\u786c\u76d8\u9a71\u52a8\u5668\uff0c\u7136\u540e\u5728\u9700\u8981\u65f6\u7528\u7f16\u7801\u4fe1\u606f\u586b\u5145\u5b83\u3002\u5373\u4fbf\u5982\u6b64\uff0c\u4ecd\u9700\u8981\u9769\u65b0DNA\u5408\u6210\u7684\u8fc7\u7a0b\uff0c\u76ee\u524d\u4e3b\u8981\u7684\u751f\u4ea7\u65b9\u6cd5\u4ecd\u7136\u662f\u5ef6\u7eed\u8fd130\u5e74\u7684\u5316\u5b66\u8fc7\u7a0b\uff0c\u9700\u8981\u81f3\u5c11\u82b1\u8d39400\u79d2\u624d\u80fd\u6dfb\u52a0\u6bcf\u4e2a\u78b1\u57fa\u3002<\/div>\n
\u6700\u540e\uff0c\u5b9e\u73b0\u5168\u81ea\u52a8\u5316\u4f7f\u5176\u6613\u7528\u3002<\/div>\n
\u00a0<\/div>\n
\u8981\u4f7f\u5f97DNA\u6570\u636e\u50a8\u5b58\u6210\u4e3a\u5e7f\u6cdb\u5e94\u7528\u7684\u5546\u4e1a\u5316\u4ea7\u54c1\uff0c\u9700\u8981\u5b8c\u6210\u5408\u6210\u3001\u5b58\u50a8\u548c\u6d4b\u5e8f\u7b49\u6574\u4e2a\u8fc7\u7a0b\u7684\u81ea\u52a8\u5316\u3002<\/div>\n
\u00a0<\/div>\n
2019\u5e74\uff0c\u534e\u76db\u987f\u5927\u5b66\u548c\u5fae\u8f6f\u53d1\u5e03\u7b2c\u4e00\u4e2a\u5904\u74065\u4e2a\u5b57\u8282\uff08\u201chello\u201d\uff09\u7684\u6570\u636e\u7684\u7aef\u5230\u7aef\u5b58\u50a8\u8bbe\u5907\uff08\u89c1\u56fe5\uff09\uff0c\u4e3b\u8981\u7684\u9650\u5236\u56e0\u7d20\u662f\u57fa\u4e8e\u6db2\u4f53DNA\u7684\u5b58\u50a8\u3002\u672a\u6765\u6709\u671b\u57fa\u4e8e\u7eb3\u7c73\u548c\u5fae\u6d41\u4f53\uff0c\u4f8b\u5982\u201cPuddle\u201c\u5fae\u6d41\u4f53\u5e73\u53f0\uff08Willsey\u7b49\uff0c2019\u5e74\uff09\u548c\u73bb\u7483\u8f7d\u4f53\u8131\u6c34DNA\u6591\u70b9\uff08Newman\u7b49\uff0c2019\uff09\u3002\u53e6\u4e00\u79cd\u601d\u8def\u662f\u57fa\u4e8e\u4e92\u8865\u91d1\u5c5e\u6c27\u5316\u7269\u534a\u5bfc\u4f53\uff08CMOS\uff09\u6280\u672f\uff0cTwist \u548cRoswell\u6b63\u5728\u5f00\u53d1\u76f8\u5173\u8bbe\u5907\u3002<\/div>\n
\u00a0<\/div>\n
\u524d\u666f\u548c\u8d8b\u52bf<\/div>\n
\u00a0<\/div>\n\n
\n
\"RmFicvQBAkgAwcVKvZ6BPHjHyVLZD7bMr4bBCVv6TGenFXk5KtiaCBibiazUzD9cgBWyKRicNbjImNAyoxXOdGe2Opg\"\/<\/figure><\/div>\n\n
\u56fe10\uff1aDNA\u6570\u636e\u5b58\u50a8\u7684\u5174\u8d77<\/div>\n
\uff08\u6765\u6e90\/Forbes\uff09<\/div>\n
\u5f97\u76ca\u4e8e\u9ad8\u901a\u91cfDNA\u6d4b\u5e8f\u548c\u5408\u6210\u7684\u5feb\u901f\u53d1\u5c55\uff0c\u4f7f\u5f97\u57fa\u4e8eDNA\u7684\u6570\u636e\u5b58\u50a8\u6280\u672f\u4ece\u79d1\u5e7b\u9010\u6e10\u53d8\u6210\u73b0\u5b9e\uff0c\u5c24\u5176\u4f53\u73b0\u5728\u5176\u4f18\u5f02\u7684\u5b58\u50a8\u5bc6\u5ea6\u548c\u7a33\u5b9a\u6027\u4e0a\uff0c\u4f7f\u5176\u6210\u4e3a\u78b3\u57fa\uff08\u76f8\u6bd4\u5f53\u524d\u7684\u7845\u57fa\uff09\u6863\u6848\u7684\u5de8\u5927\u6f5c\u529b\u3002<\/div>\n
\u00a0<\/div>\n
\u968f\u77402007\u5e74Illumina\u53d1\u5e03\u4e0b\u4e00\u4ee3\u9ad8\u901a\u91cf\u6d4b\u5e8f\u4eea\uff0c2015\u5e74\u534e\u5927\u53d1\u5e03\u56fd\u4ea7NGS\u6d4b\u5e8f\u4eea\uff0c\u5206\u522b\u4ece\u4e0d\u540c\u89d2\u5ea6\u63a8\u8fdb\u9ad8\u901a\u91cf\u6d4b\u5e8f\u6280\u672f\u5e94\u7528\u7684\u666e\u53ca\uff0c\u8fbe\u5230\u6bcfGB 200\u7f8e\u5143\uff08\u4eba\uff09\u7684\u6210\u672c\uff0c\u63a8\u52a8\u5168\u7403\u8d85\u8fc710\u4e2a\u56fd\u5bb6\u8fdb\u884c\u5341\u4e07\u4eba\u7ea7\u57fa\u56e0\u961f\u5217\u7814\u7a76\u3002<\/div>\n
\u00a0<\/div>\n
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\u00a0<\/div>\n

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\n
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\u56fe11\uff1aDNA\u6570\u636e\u5b58\u50a8\u7684\u6295\u8d44\u5f62\u5f0f<\/div>\n
\uff08\u6765\u6e90\/doi:10.1016\/j.biotechadv.2020.107639\uff09<\/div>\n
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10\u5e74\u524d\u5728\u5fb7\u56fd\u65c5\u9986\u9152\u5427\u91cc\u6cae\u4e27\u7684Nick Goldman\uff0c\u6700\u8fd1\u5237\u65b0\u4e86\u5bf9\u672a\u6765\u7684\u671f\u5f85\uff0c\u5728DNA\u6570\u636e\u5b58\u50a8\u5b8c\u5168\u666e\u904d\u4e4b\u524d\uff0c\u81f3\u5c11\u9700\u8981\u5341\u4e07\u500d\u6570\u91cf\u7ea7\u7684\u6539\u5584\u3002\u800c\u6211\u4eec\u77e5\u9053\u77ed\u77ed20\u5e74\uff0c\u57fa\u56e0\u6d4b\u5e8f\u5df2\u7ecf\u5f97\u5230\u4e86\u767e\u4e07\u500d\u6570\u91cf\u7ea7\u7684\u6539\u5584\u3002<\/div>\n
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\u00a0<\/div>\n
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1.Randolph Lopez et. al., DNA assembly for nanopore data storage readout, Nat Commun, 2019<\/div>\n
2.\u00a0Zhi Ping et.al., Carbon-based archiving: current progress and future prospects of DNA-based data storage, Gigascience, 2019<\/div>\n
3.\u00a0Philip M.Stanley et.al., Decoding DNA data storage for investment, Biotechnology Advances,2020<\/div>\n
4.\u00a0https:\/\/nuclineers.com\/dna-data-storage<\/div>\n
5. https:\/\/www.digitaltrends.com\/cool-tech\/dna-data-catalog-startup<\/div>\n
6.https:\/\/www.nature.com\/news\/how-dna-could-store-all-the-world-s-data-1.20496<\/div>\n
7.\u00a0https:\/\/www.nanalyze.com\/2017\/01\/dna-data-storage-technology-available<\/div>\n
8.https:\/\/www.forbes.com\/sites\/johncumbers\/2019\/08\/03\/dna-data-storage-is-about-to-go-viral\/?sh=3ac873b77721<\/div>\n
9.https:\/\/www.scientificamerican.com\/article\/dna-data-storage-is-closer-than-you-think<\/div>\n
10.https:\/\/www.technologyreview.com\/2017\/05\/22\/68387\/microsoft-has-a-plan-to-add-dna-data-storage-to-its-cloud<\/div>\n
11.https:\/\/blocksandfiles.com\/2020\/03\/18\/catalog-cdna-data-storage-economically-feasible<\/div>\n
12.https:\/\/www.geneticsdigest.com\/the-role-of-dna-data-storage-in-health-and-technology\/<\/div>\n
13.https:\/\/www.nanalyze.com\/2017\/01\/dna-data-storage-technology-available\/<\/div>\n
14.http:\/\/www.ssbt.org.cn\/upload\/20191212153656_562.pdf<\/div>\n
15.https:\/\/www.nature.com\/articles\/s41576-019-0125-3<\/div>\n
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