{"id":8965,"date":"2020-12-30T12:34:30","date_gmt":"2020-12-30T04:34:30","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&#038;mid=100017970&#038;idx=1&#038;sn=ed0a507b21ab31a8036bfe3cc79e7b3b&#038;chksm=6b7175855c06fc93e6e07463839b0b250345d1216e3aad616c86876ab88bc01018c7b1558fcf#rd"},"modified":"2026-04-08T09:33:57","modified_gmt":"2026-04-08T01:33:57","slug":"495098-3","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2020\/12\/30\/495098-3\/","title":{"rendered":"Cell \u4e28\u201c\u593a\u547d\u201d\u8731\u866b\u57fa\u56e0\u7ec4\u7814\u7a76\u6210\u679c\uff0c\u89e3\u6790\u8731\u866b\u4e13\u6027\u5438\u8840\u9057\u4f20\u673a\u5236"},"content":{"rendered":"<p><!-- wechat_content_hash: 12b2c1072d8aef85 --><\/p>\n<div>\u3010\u5bfc\u8bed\u30112020\u5e748\u6708\uff0c\u519b\u4e8b\u79d1\u5b66\u9662\u519b\u4e8b\u533b\u5b66\u7814\u7a76\u9662\u5fae\u751f\u7269\u6d41\u884c\u75c5\u7814\u7a76\u6240\u66f9\u52a1\u6625\u56e2\u961f\u3001\u4e2d\u56fd\u79d1\u5b66\u9662\u5317\u4eac\u751f\u547d\u79d1\u5b66\u7814\u7a76\u9662\u8d75\u65b9\u5e86\u56e2\u961f\u4e0e\u5b89\u8bfa\u4f18\u8fbe\u8054\u5408\u5728Cell\u53d1\u8868\u8731\u866b\u57fa\u56e0\u7ec4\u7814\u7a76\u8bba\u6587\uff0c\u8be5\u7814\u7a76\u7cfb\u7edf\u9610\u793a\u4e86\u4e0d\u540c\u8731\u79cd\u7684\u6f14\u5316\u53f2\u53ca\u5206\u5316\u65f6\u95f4\uff0c\u63ed\u793a\u4e86\u8731\u4e13\u6027\u5438\u8840\u7684\u9057\u4f20\u673a\u5236\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u6587\u7ae0 | \u5b89\u8bfa\u4f18\u8fbe\u7f16\u8f91 | \u7f57\u6e58@\u57fa\u56e0\u6167<\/div>\n<div>\u5173\u952e\u8bcd | \u57fa\u56e0\u7ec4 \u79d1\u7814<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgChQooMJE8LUFBc4w3MoMLbsjKTLO7QBx3viaP6IAia5KYHXWykqaqTePTKwjkdzLNicpXiamGcB0KqEw.jpeg\" alt=\"RmFicvQBAkgChQooMJE8LUFBc4w3MoMLbsjKTLO7QBx3viaP6IAia5KYHXWykqaqTePTKwjkdzLNicpXiamGcB0KqEw\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u6765\u6e90\/https:\/\/doi.org\/10.1016\/j.cell.2020.07.023<\/div>\n<div>\u8fd9\u7bc7\u7814\u7a76\u8bba\u6587\u9898\u4e3a\u201cLarge-scale comparative analyses of tick genomes elucidate their genetic diversity and vector capacities\u201d\uff0c\u57fa\u4e8e\u7ec4\u88c5\u83b7\u5f97\u7684\u9ad8\u8d28\u91cf\u53c2\u8003\u57fa\u56e0\u7ec4\uff0c\u9996\u6b21\u9610\u660e\u4e86\u8731\u866b\u57fa\u56e0\u7ec4\u4e0e\u7fa4\u4f53\u9057\u4f20\u7ed3\u6784\u591a\u6837\u6027\uff0c\u4e3a\u6df1\u5165\u5f00\u5c55\u8731\u866b\u53ca\u8731\u5a92\u75c5\u7684\u673a\u5236\u7814\u7a76\u5960\u5b9a\u4e86\u57fa\u7840\u3002<\/div>\n<div>\u00a0<\/div>\n<div style=\"text-align: center;\">01<\/div>\n<div style=\"text-align: center;\">\u7814\u7a76\u80cc\u666f<\/div>\n<div>\u8731\u866b\u662f\u4e13\u8425\u5438\u8840\u6027\u8282\u80a2\u52a8\u7269\uff0c\u80fd\u591f\u901a\u8fc7\u53ee\u54ac\u5c06\u7ec6\u83cc\u3001\u539f\u751f\u52a8\u7269\u3001\u771f\u83cc\u3001\u7ebf\u866b\u3001\u75c5\u6bd2\u7b49\u75c5\u539f\u4f53\u4f20\u64ad\u7ed9\u4eba\u7c7b\u3001\u7272\u755c\u53ca\u91ce\u751f\u751f\u7269\uff0c\u5f15\u8d77\u83b1\u59c6\u75c5\u3001\u7acb\u514b\u6b21\u6c0f\u75c5\u7b49\u591a\u79cd\u75be\u75c5\u7684\u53d1\u751f\uff0c\u4e14\u5177\u6709\u6301\u4e45\u6027\u548c\u590d\u53d1\u6027\u611f\u67d3\u7b49\u7279\u70b9\uff0c\u4f1a\u5bfc\u81f4\u6709\u673a\u4f53\u6b7b\u4ea1\u6216\u51fa\u73b0\u6162\u6027\u540e\u9057\u75c7\uff0c\u5371\u5bb3\u4eba\u7c7b\u5065\u5eb7\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u8fd1\u5e74\u6765\uff0c\u968f\u7740\u6c14\u5019\u548c\u73af\u5883\u53d8\u5316\uff0c\u8731\u866b\u7684\u6570\u91cf\u6fc0\u589e\uff0c\u5176\u6816\u606f\u5730\u5feb\u901f\u6269\u5f20\uff0c\u4eba\u4eec\u88ab\u8731\u866b\u53ee\u54ac\u7684\u4e8b\u4ef6\u591a\u6709\u62a5\u9053\uff0c\u4f46\u76ee\u524d\u8fd8\u7f3a\u5c11\u6709\u6548\u63aa\u65bd\u63a7\u5236\u8731\u5a92\u75c5\u7684\u4f20\u64ad\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u9ad8\u8d28\u91cf\u7684\u53c2\u8003\u57fa\u56e0\u7ec4\u662f\u63a2\u7a76\u8731\u866b\u7684\u751f\u7269\u5b66\u7279\u6027\u3001\u5bbf\u4e3b-\u75c5\u539f\u4f53\u4e92\u4f5c\u673a\u5236\u3001\u4f20\u64ad\u548c\u63a7\u5236\u7b56\u7565\u7b49\u751f\u7269\u5b66\u95ee\u9898\u7684\u57fa\u7840\uff0c\u8731\u866b\u79cd\u7c7b\u7e41\u591a\uff0c\u4f46\u76ee\u524d\u4ec5\u6709\u80a9\u7a81\u786c\u8731\uff08I. scapularis\uff09\u57fa\u56e0\u7ec4\u53d1\u5e03\uff0c\u4e25\u91cd\u5236\u7ea6\u4e86\u8731\u866b\u53ca\u8731\u5a92\u75c5\u9632\u63a7\u5de5\u4f5c\u7684\u5f00\u5c55\u3002<\/div>\n<div>\u00a0<\/div>\n<div style=\"text-align: center;\">02<\/div>\n<div style=\"text-align: center;\">\u4e3b\u8981\u7814\u7a76\u7ed3\u679c<\/div>\n<div>\u25a0 \u57fa\u56e0\u7ec4\u7ec4\u88c5\u53ca\u8d28\u91cf\u8bc4\u4f30<\/div>\n<div>\u8be5\u7814\u7a76\u4ee5\u516d\u79cd\u8731\u866b\u4e3a\u7814\u7a76\u6750\u6599\uff0c\u9996\u5148\u5229\u7528\u4e8c\u4ee3\u6570\u636e\u5bf9\u8731\u866b\u7684\u57fa\u56e0\u7ec4\u5927\u5c0f\u8fdb\u884c\u4e86\u9884\u4f30\uff0c\u968f\u540e\uff0c\u57fa\u4e8ePacBio\u4e09\u4ee3\u6d4b\u5e8f\u83b7\u5f97\u768467\u201395X Subreads\u8fdb\u884c\u57fa\u56e0\u7ec4\u7ec4\u88c5\u3002\u5728\u6b64\u57fa\u7840\u4e0a\uff0c\u501f\u52a9Hi-C\u8f85\u52a9\u7ec4\u88c5\u6280\u672f\u5c068,620-15,174 \u6761Contigs\u951a\u5b9a\u5230\u4e8611\u6761\u67d3\u8272\u4f53\u4e0a\uff0c\u6700\u7ec8\u83b7\u5f97\u4e861.5-2.3 Gb\u5927\u5c0f\u7684\u67d3\u8272\u4f53\u6c34\u5e73\u7684\u8731\u866b\u57fa\u56e0\u7ec4\uff0c\u90e8\u5206\u57fa\u56e0\u7ec4\u7684Scaffold N50\u8fbe\u5230\u4e86208.7 Mb\uff0cContig N50 1.8 Mb\uff08\u88681\uff0c\u56fe1\uff09\u3002BUSCO\u8bc4\u4f30\u5927\u4e8e90%\uff0cillumina\u77edreads\u7684\u8986\u76d6\u5ea6\u4e5f\u90fd\u572896%\u4ee5\u4e0a\uff0c\u8868\u660e\u7ec4\u88c5\u57fa\u56e0\u7ec4\u5177\u6709\u8f83\u597d\u7684\u5b8c\u6574\u6027\u548c\u51c6\u786e\u5ea6\uff0c\u53ef\u7528\u4e8e\u540e\u7eed\u7814\u7a76\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgChQooMJE8LUFBc4w3MoMLbrEoIJjibo4O3j1YfSSrKcMpXic0ibvXDzc9AkvzzOLzZgog93g70Lcibwg.jpeg\" alt=\"RmFicvQBAkgChQooMJE8LUFBc4w3MoMLbrEoIJjibo4O3j1YfSSrKcMpXic0ibvXDzc9AkvzzOLzZgog93g70Lcibwg\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u88681 \uff1a\u8731\u866b\u57fa\u56e0\u7ec4\u7684\u7ec4\u88c5\u548c\u6ce8\u91ca\u4fe1\u606f\u7edf\u8ba1<\/div>\n<div>\u25a0 \u8731\u866b\u57fa\u56e0\u7ec4\u7279\u5f81\u53ca\u8fdb\u5316\u5206\u6790<\/div>\n<div>\u8731\u866b\u57fa\u56e0\u7ec4\u4e2d\u7ea652.6\uff05-64.4\uff05\u4e3a\u91cd\u590d\u5e8f\u5217\uff0c\u4e14\u591a\u4e3a\u957f\u6563\u5728\u91cd\u590d\u5e8f\u5217\uff08Line\uff09\u548c\u957f\u672b\u7aef\u91cd\u590d\u5e8f\u5217\uff08LTR\uff09\u3002\u516d\u79cd\u8731\u866b\u57fa\u56e0\u7ec4\u542b\u6709\u7684\u86cb\u767d\u7f16\u7801\u57fa\u56e0\u6570\u91cf\u4e0d\u540c\uff08\u88681\uff09\uff0c\u4e14\u57fa\u56e0\u7684\u5e73\u5747\u957f\u5ea6\u3001\u5916\u663e\u5b50\u6570\u91cf\u3001\u5185\u542b\u5b50\u5e73\u5747\u957f\u5ea6\u7b49\u9057\u4f20\u7ed3\u6784\u5b58\u5728\u663e\u8457\u5dee\u5f02\u3002\u8fdb\u4e00\u6b65\u7684\u7cfb\u7edf\u8fdb\u5316\u5206\u6790\u663e\u793a\uff0c\u786c\u8731\u5c5e\u8731\u866b\u4e0e\u5176\u4ed6\u8731\u79cd\u5728200 Mya\u5e74\u524d\u53d1\u751f\u4e86\u5206\u6b67\uff0c\u4f7f\u5f97I. persulcatus\u4e0e\u5176\u4ed6\u8731\u79cd\u4e4b\u95f4\u5177\u6709\u8f83\u5927\u7684\u9057\u4f20\u5dee\u5f02\u3002H. longicornis\u3001R. microplus\u3001R. sanguineus\u3001H. asiaticum\u548cD. silvarum\u5728137.8 Mya\u524d\u7531\u5171\u540c\u7956\u5148\u5206\u5316\u800c\u6765\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgChQooMJE8LUFBc4w3MoMLbS671yroVhxTe4f6Sia4fTPaH0nib9veW0W9K29oTC8vqiaCBXM4D1qSlQ.jpeg\" alt=\"RmFicvQBAkgChQooMJE8LUFBc4w3MoMLbS671yroVhxTe4f6Sia4fTPaH0nib9veW0W9K29oTC8vqiaCBXM4D1qSlQ\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe1 \uff1a\u8731\u866b\u57fa\u56e0\u7ec4\u7279\u5f81\u53ca\u8fdb\u5316\u5206\u6790<\/div>\n<div>\u25a0 \u8731\u866b\u5438\u8840\u7684\u9057\u4f20\u57fa\u7840\u53ca\u8868\u578b<\/div>\n<div>\u8731\u866b\u57fa\u56e0\u7ec4\u4e2d\u86cb\u767d\u9176\u6d3b\u6027\u3001\u8f6c\u79fb\u9176\u6d3b\u6027\u3001\u8f6c\u5f55\u8c03\u63a7\u3001\u8f6c\u8fd0\u86cb\u767d\u6d3b\u6027\u548c\u514d\u75ab\u76f8\u5173\u86cb\u767d\u5bb6\u65cf\u7684\u6269\u5f20\uff08\u56fe2A\uff09\uff0c\u4f1a\u5f71\u54cd\u8731\u866b\u5bf9\u8840\u7ea2\u86cb\u767d\u7684\u6d88\u5316\u3001\u8840\u7ea2\u7d20\u8fd0\u8f93\u3001\u89e3\u6bd2\u3001\u6c27\u5316\u80c1\u8feb\u54cd\u5e94\u7b49\u751f\u7269\u5b66\u8fc7\u7a0b\uff0c\u4f7f\u5f97\u8731\u866b\u5177\u6709\u8f83\u5f3a\u7684\u5438\u8840\u80fd\u529b\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgChQooMJE8LUFBc4w3MoMLbHCibAGIzKichX4nicCibbxciccSJJRRklPTFjdqIPfFrWRInRtJBglpGLbg.jpeg\" alt=\"RmFicvQBAkgChQooMJE8LUFBc4w3MoMLbHCibAGIzKichX4nicCibbxciccSJJRRklPTFjdqIPfFrWRInRtJBglpGLbg\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe2\uff1a\u8731\u866b\u5438\u8840\u7684\u9057\u4f20\u57fa\u7840\u548c\u76f8\u5173\u8868\u578b<\/div>\n<div>\u8731\u866b\u5728\u5bc4\u4e3b\u4e0a\u7684\u9644\u7740\u65f6\u95f4\u53d7\u4e2a\u4f53\u7684\u89e3\u6bd2\u80fd\u529b\u3001\u5bbf\u4e3b\u5bfb\u627e\u3001\u8840\u6db2\u6d88\u5316\u80fd\u529b\u3001\u8425\u517b\u4ee3\u8c22\u3001\u514d\u75ab\u53cd\u5e94\u7b49\u591a\u79cd\u56e0\u7d20\u5f71\u54cd\uff08\u56fe2B\uff09\u3002\u4f5c\u4e3a\u8840\u6db2\u4f9d\u8d56\u6027\u751f\u7269\uff0c\u8731\u866b\u57fa\u56e0\u7ec4\u4e2d\u53c2\u4e0e\u8c03\u63a7\u8840\u7ea2\u7d20\u751f\u7269\u5408\u6210\u548c\u964d\u89e3\u7684\u57fa\u56e0\u867d\u53d1\u751f\u4e86\u4e22\u5931\uff0c\u4f46\u5176\u57fa\u56e0\u7ec4\u4e2d\u53c2\u4e0e\u94c1\u4ee3\u8c22\u7684TMPRSS6\u53d1\u751f\u4e86\u6269\u5f20\uff0c\u4f7f\u5f97\u8731\u866b\u80fd\u591f\u4ece\u5bbf\u4e3b\u4e2d\u83b7\u53d6\u548c\u8fd0\u8f93\u4e9a\u94c1\u8840\u7ea2\u7d20\u548c\u94c1\uff0c\u6765\u7ef4\u6301\u81ea\u8eab\u7684\u5173\u952e\u751f\u7406\u8fc7\u7a0b\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u4e0e\u6b64\u540c\u65f6\uff0c\u6e38\u79bb\u7684\u4e9a\u94c1\u8840\u7ea2\u7d20\u548c\u94c1\u4f1a\u5bfc\u81f4\u6d3b\u6027\u6c27\uff08ROS\uff09\u7684\u4ea7\u751f\uff0c\u8731\u866b\u57fa\u56e0\u7ec4\u4e2d\u7684\u6297\u6c27\u5316\u9176\u3001\u81ea\u7531\u57fa\u6e05\u9664\u5242\u3001\u8840\u7ea2\u7d20\u4ecb\u5bfc\u7684ROS\u76f8\u5173\u7684\u6fc0\u6d3b\u56e0\u5b50\u7f16\u7801\u57fa\u56e0\u5177\u6709\u8f83\u9ad8\u7684\u4fdd\u5b88\u6027\uff0c\u4f7f\u5f97\u8731\u866b\u80fd\u591f\u7ef4\u62a4\u81ea\u8eab\u7684\u6c27\u5316\u8fd8\u539f\u5e73\u8861\uff0c\u514d\u53d7\u6c27\u5316\u80c1\u8feb\u6bd2\u5bb3\u3002\u6b64\u5916\uff0c\u8731\u866b\u8fd8\u8fdb\u5316\u51fa\u4e86\u591a\u79cd\u80de\u5185\u548c\u4f53\u6db2\u514d\u75ab\u80fd\u529b\uff0c\u4f7f\u5f97\u5176\u80fd\u591f\u5438\u9644\u4e8e\u5bbf\u4e3b\u8868\u9762\u5e76\u4fdd\u6301\u5e73\u8861\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u25a0 \u7fa4\u4f53\u7ed3\u6784\u548c\u9057\u4f20\u591a\u6837\u6027<\/div>\n<div>\u6211\u56fd\u8731\u866b\u79cd\u7c7b\u591a\u6837\uff0c\u4f46\u7531\u4e8e\u57fa\u56e0\u7ec4\u4fe1\u606f\u7f3a\u4e4f\uff0c\u5bf9\u8731\u866b\u9057\u4f20\u591a\u6837\u6027\u53ca\u5206\u5e03\u89c4\u5f8b\u7684\u7814\u7a76\u5de5\u4f5c\u4e00\u76f4\u96be\u4ee5\u5f00\u5c55\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u8be5\u7814\u7a76\u57fa\u4e8e\u7ec4\u88c5\u83b7\u5f97\u7684\u9ad8\u8d28\u91cf\u8731\u866b\u57fa\u56e0\u7ec4\uff0c\u5bf9\u6765\u6e90\u4e8e\u4e0d\u540c\u5730\u57df\u548c\u751f\u5883\u7684678\u4e2a\u91ce\u751f\u8731\u866b\u8fdb\u884c\u91cd\u6d4b\u5e8f\uff0c\u53d1\u73b0\u4e0d\u540c\u7c7b\u522b\u7684\u8731\u866b\u867d\u5177\u6709\u76f8\u4f3c\u7684\u6269\u6563\u7b56\u7565\uff0c\u4f46\u5176\u7fa4\u4f53\u8fdb\u5316\u5177\u6709\u660e\u663e\u7684\u751f\u6001\u5730\u57df\u6027\u548c\u7269\u79cd\u7279\u5f02\u6027\u3002\u4f8b\u5982\uff0c\u6765\u81ea\u65b0\u7586\u548c\u5185\u8499\u53e4\u7684H. asiaticum\uff0c\u867d\u5728\u5f62\u6001\u4e0a\u6781\u4e3a\u76f8\u4f3c\uff0c\u5374\u5177\u6709\u4e0d\u540c\u7684\u9057\u4f20\u7279\u6027\uff1bH. longicornis\u867d\u7136\u5206\u5e03\u8f83\u5e7f\uff0c\u4f46\u5176\u9057\u4f20\u591a\u6837\u6027\u76f8\u5bf9\u8f83\u4f4e\u3001\u57fa\u56e0\u7ec4\u76f8\u5bf9\u4fdd\u5b88\uff1b\u5355\u5bbf\u4e3b\u8731\u79cdR. microplus\u660e\u663e\u5177\u6709\u4e09\u4e2a\u4e0d\u540c\u7684\u5730\u57df\u6027\u8fdb\u5316\u5206\u652f\uff0c\u6697\u793a\u4e86\u5355\u4e00\u7684\u5bbf\u4e3b\u7279\u6027\u53ef\u80fd\u4fc3\u6210\u4e86\u4e0d\u540c\u5730\u57dfR. microplus\u7684\u8fdb\u5316\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgChQooMJE8LUFBc4w3MoMLbAVmavWQwpO2rc6nMGNKvt6yic7c7JA7ibgd9eYPFBEKCtu8kAdn3BmCg.jpeg\" alt=\"RmFicvQBAkgChQooMJE8LUFBc4w3MoMLbAVmavWQwpO2rc6nMGNKvt6yic7c7JA7ibgd9eYPFBEKCtu8kAdn3BmCg\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe3\uff1a\u8731\u866b\u9057\u4f20\u591a\u6837\u6027\u548c\u7fa4\u4f53\u7ed3\u6784\u5206\u6790<\/div>\n<div>\u25a0 \u5f71\u54cd\u8731\u5a92\u75c5\u539f\u4f53\u5206\u5e03\u7684\u5173\u952e\u56e0\u7d20<\/div>\n<div>\u8731\u866b\u57fa\u56e0\u7ec4\u7684\u591a\u6837\u6027\u51b3\u5b9a\u4e86\u8731\u866b\u4e0e\u75c5\u539f\u4f53\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u4f1a\u975e\u5e38\u590d\u6742\uff0c\u9700\u8981\u8fdb\u4e00\u6b65\u63a2\u7a76\u8731\u5a92\u75c5\u539f\u4f53\u7684\u751f\u6001\u5206\u5e03\u548c\u8fdb\u5316\u673a\u5236\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgChQooMJE8LUFBc4w3MoMLbG1CvBH0L9zPxAjDwSjZ6iczQ9COnsEUsmiaAtPyPekjHHnibxKoQKZZmw.jpeg\" alt=\"RmFicvQBAkgChQooMJE8LUFBc4w3MoMLbG1CvBH0L9zPxAjDwSjZ6iczQ9COnsEUsmiaAtPyPekjHHnibxKoQKZZmw\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe4\uff1a\u8731\u5a92\u75c5\u539f\u4f53\u5206\u6790<\/div>\n<div>\u8be5\u7814\u7a76\u5229\u7528\u5b8f\u57fa\u56e0\u7ec4\u5b66\u5bf9\u5bbf\u4e3b\u57fa\u56e0\u6d41\u5bf9\u75c5\u539f\u4f53\u5206\u5e03\u7684\u5f71\u54cd\u8fdb\u884c\u4e86\u8bc4\u4f30\uff0c\u53d1\u73b0\u75c5\u539f\u4f53\u7684\u5206\u5e03\u4e0e\u6784\u6210\u4e5f\u5177\u6709\u8731\u79cd\u7279\u5f02\u6027\u548c\u751f\u6001\u5730\u57df\u6027\uff1aI. persulcatus\u00a0\u643a\u5e26\u7684\u75c5\u539f\u4f53\u79cd\u7c7b\u6700\u591a\uff0cR. sanguineus\u00a0\u4e2d\u8f83\u5c11\uff0cD. silvarum\u00a0\u4e2d\u7acb\u514b\u6b21\u4f53\u7684\u4e30\u5ea6\u548c\u5360\u6bd4\u5f88\u9ad8\uff1b\u5373\u4f7f\u662f\u751f\u6d3b\u5728\u4e0d\u540c\u751f\u6001\u5730\u57df\u7684\u540c\u4e00\u8731\u79cd\uff0c\u643a\u5e26\u7684\u7acb\u514b\u6b21\u4f53\u79cd\u7c7b\u4e5f\u6709\u6240\u4e0d\u540c\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u9ad8\u4e30\u5ea6\uff08\u5982\u7acb\u514b\u6b21\u4f53\uff09\u548c\u4f4e\u4e30\u5ea6\uff08\u5982\u87ba\u65cb\u4f53\uff09\u7684\u75c5\u539f\u4f53\uff0c\u90fd\u53ef\u4ee5\u7ecf\u8731\u4f20\u64ad\uff0c\u5f15\u53d1\u8731\u5a92\u4f20\u67d3\u75c5\uff08\u5982\u7acb\u514b\u6b21\u4f53\u75c5\u4e0e\u83b1\u59c6\u75c5\uff09\uff0c\u56e0\u6b64\uff0c\u9700\u8981\u5efa\u7acb\u66f4\u7075\u654f\u7684\u68c0\u6d4b\u65b9\u6cd5\u76d1\u6d4b\u4f4e\u4e30\u5ea6\u7684\u75c5\u539f\u4f53\uff0c\u7528\u4e8e\u8731\u5a92\u75c5\u7684\u9632\u63a7\u3002<\/div>\n<div>\u00a0<\/div>\n<div style=\"text-align: center;\">03<\/div>\n<div style=\"text-align: center;\">\u6587\u7ae0\u603b\u7ed3<\/div>\n<div>\u25a0 \u8be5\u7814\u7a76\u5229\u7528\u4e8c\u4ee3\u3001\u4e09\u4ee3\u548cHi-C\u8f85\u52a9\u7ec4\u88c5\u76f8\u7ed3\u5408\u7684\u6d4b\u5e8f\u7b56\u7565\uff0c\u7ec4\u88c5\u83b7\u5f97\u4e86\u516d\u4e2a\u9ad8\u7cbe\u5ea6\u7684\u67d3\u8272\u4f53\u6c34\u5e73\u7684\u8731\u866b\u57fa\u56e0\u7ec4\u3002<\/div>\n<div>\u25a0 \u57fa\u4e8e\u7ec4\u88c5\u7684\u53c2\u8003\u57fa\u56e0\u7ec4\uff0c\u7cfb\u7edf\u9610\u793a\u4e86\u4e0d\u540c\u8731\u79cd\u7684\u6f14\u5316\u53f2\u53ca\u5206\u5316\u65f6\u95f4\uff0c\u5e76\u901a\u8fc7\u6bd4\u8f83\u57fa\u56e0\u7ec4\u548c\u8f6c\u5f55\u7ec4\u5b66\u5206\u6790\uff0c\u4ece\u8840\u7ea2\u7d20\u5229\u7528\u3001\u94c1\u4ee3\u8c22\u3001\u6d3b\u6027\u6c27\uff08ROS\uff09\u5e73\u8861\u3001\u7ec6\u80de\u4e0e\u4f53\u6db2\u514d\u75ab\u7b49\u65b9\u9762\u63ed\u793a\u4e86\u8731\u4e13\u6027\u5438\u8840\u7684\u9057\u4f20\u673a\u5236\u3002\u00a0<\/div>\n<div>\u25a0 \u8731\u79cd\u7279\u5f02\u6027\u548c\u751f\u6001\u5730\u57df\u6027\u90fd\u4f1a\u5f71\u54cd\u8731\u5a92\u75c5\u539f\u4f53\u7684\u5206\u5e03\uff0c\u9ad8\u4e30\u5ea6\u548c\u4f4e\u4e30\u5ea6\u7684\u75c5\u539f\u4f53\u90fd\u80fd\u591f\u5f15\u53d1\u8731\u5a92\u4f20\u67d3\u75c5\uff0c\u9700\u8981\u5efa\u7acb\u66f4\u7075\u654f\u7684\u68c0\u6d4b\u65b9\u6cd5\u76d1\u6d4b\u4f4e\u4e30\u5ea6\u7684\u75c5\u539f\u4f53\uff0c\u9632\u63a7\u8731\u5a92\u75c5\u7684\u4f20\u64ad\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u5b89\u8bfa\u57fa\u56e0\u914d\u5907\u4e86\u4e00\u7cfb\u5217\u5148\u8fdb\u7684\u5206\u5b50\u751f\u7269\u5b66\u4eea\u5668\u8bbe\u5907\uff0c\u5b9e\u73b0\u4e86\u4ece\u6837\u672c\u63d0\u53d6\u3001\u6587\u5e93\u5236\u5907\u5230\u4e0a\u673a\u6d4b\u5e8f\u7684\u5168\u81ea\u52a8\u5316\u64cd\u4f5c\uff0c\u5148\u8fdb\u7684\u4e09\u4ee3PacBio\uff087\u53f0Sequel 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