{"id":8942,"date":"2021-02-07T22:46:58","date_gmt":"2021-02-07T14:46:58","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&mid=100018468&idx=1&sn=7103ebb979be659432b98fbc3768a677&chksm=6b717b935c06f285ffd34a3d1efa03d30ea9c31ab1b7d38eb2ac09cbc42d93ffd86e995b07d8#rd"},"modified":"2026-04-08T09:27:18","modified_gmt":"2026-04-08T01:27:18","slug":"5210156","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2021\/02\/07\/5210156\/","title":{"rendered":"\u73af\u7403\u7f51\uff1a\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u5e26\u7ed9\u6211\u4eec\u7684\u91cd\u8981\u542f\u793a"},"content":{"rendered":"

<\/p>\n

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\u00a0<\/div>\n
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\u7f16\u8f91 | \u5e03\u4e09\u5c11\u00a0 \u5173\u952e\u8bcd |\u00a0\u6218\u7565\u601d\u8003<\/div>\n\n
\n
\"RmFicvQBAkgDKictuKJ31iaLAaib8IdtqtmoxmByoeRDPGqibDibdrS05rPaG2eGTInic8sreEa7Zgib4PHiaOWmrLe8Q2w\"\/<\/figure><\/div>\n\n
\u56fe\uff1aHuman Genome at 20\uff08\u6765\u6e90\/Science\uff09<\/div>\n
\u751f\u547d\u79d1\u5b66\u7684\u201c\u767b\u6708\u8ba1\u5212\u201d<\/div>\n
\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\uff08Human Genome Project, HGP\uff09\u662f\u4e00\u9879\u89c4\u6a21\u5b8f\u5927\u3001\u8de8\u56fd\u8de8\u5b66\u79d1\u7684\u79d1\u5b66\u63a2\u7d22\u5de5\u7a0b\u3002\u5176\u65e8\u5728\u6d4b\u5b9a\u7ec4\u6210\u4eba\u7c7b\u67d3\u8272\u4f53\u768430\u4ebf\u4e2a\u78b1\u57fa\u5bf9\u7684\u6838\u82f7\u9178\u5e8f\u5217\uff0c\u4ece\u800c\u7ed8\u5236\u4eba\u7c7b\u57fa\u56e0\u7ec4\u56fe\u8c31\uff0c\u5e76\u8fa8\u8bc6\u5176\u8f7d\u6709\u7684\u57fa\u56e0\u53ca\u5176\u5e8f\u5217\uff0c\u8fbe\u5230\u7834\u8bd1\u4eba\u7c7b\u9057\u4f20\u4fe1\u606f\u7684\u6700\u7ec8\u76ee\u7684\u3002<\/div>\n
\u00a0<\/div>\n
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\u00a0<\/div>\n
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\u00a0<\/div>\n
\u7f8e\u56fd\u56fd\u5bb6\u4eba\u7c7b\u57fa\u56e0\u7ec4\u7814\u7a76\u6240\uff08National Human GenomeResearch Ins\uff0cNHGRI\uff09\u8d1f\u8d23\u4eba\u57c3\u91cc\u514b\u00b7D\u00b7\u683c\u6797\u6240\u8a00\uff1a\u201c\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u5bf9\u79d1\u5b66\u7684\u5f71\u54cd\u4e0d\u53ef\u4f30\u91cf\u3002\u968f\u7740\u5bf9\u75be\u75c5\u7684\u57fa\u56e0\u7ec4\u57fa\u7840\u548c\u57fa\u56e0\u7ec4\u836f\u7269\u7b49\u8ba4\u8bc6\u52a0\u6df1\uff0c\u4eba\u7c7b\u5411\u6700\u7ec8\u76ee\u6807\u2014\u2014\u901a\u8fc7\u57fa\u56e0\u7ec4\u5b66\u7814\u7a76\u6539\u5584\u4eba\u7c7b\u5065\u5eb7\u2014\u2014\u8d8a\u8d70\u8d8a\u8fd1\u3002\u201d<\/div>\n
\u8fd920\u5e74\uff0c\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6280\u672f\u7684\u98de\u901f\u53d1\u5c55\uff0c\u63a8\u52a8\u6210\u672c\u76f4\u7ebf\u4e0b\u964d\u3002\u4e00\u4e2a\u4eba\u7684\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6210\u672c\u4ece38\u4ebf\u7f8e\u5143\u4e0b\u964d\u5230\u4e0d\u8db31000\u7f8e\u5143\uff0c\u800c\u4e14\u53ea\u9700\u8981\u4e00\u4e24\u5929\u65f6\u95f4\u3002\u5982\u540c\u6469\u5c14\u5b9a\u5f8b\u5e26\u6765\u7684\u4e92\u8054\u7f51\u666e\u53ca\uff0c\u201c\u4eba\u4eba\u57fa\u56e0\u7ec4\u201d\u65f6\u4ee3\u7684\u5230\u6765\uff0c\u53ea\u662f\u4e2a\u65f6\u95f4\u95ee\u9898\u3002<\/div>\n
\u00a0<\/div>\n
\u7b2c\u4e00\u540d\u88abDNA\u6d4b\u5e8f\u62ef\u6551\u7684\u513f\u7ae5<\/div>\n\n
\n
\"RmFicvQBAkgDKictuKJ31iaLAaib8IdtqtmoiacZ9zz7j8DfPiaYMqR9NicY4MU5qYEGspYqL4WtJOFhyYoS1HP8webAA\"\/<\/figure><\/div>\n\n
\u56fe\uff1aNicholas Volker\uff08\u6765\u6e90\/http:\/\/wipps.org\uff09<\/div>\n
2010\u5e74\uff0c6\u5c81\u7684\u7f8e\u56fd\u7537\u5b69\u5c3c\u53e4\u62c9\u65af\u00b7\u6c83\u5c14\u514b\uff08Nicholas Volker\uff09\u6210\u4e3a\u4e16\u754c\u4e0a\u7b2c\u4e00\u4e2a\u88ab\u57fa\u56e0\u6d4b\u5e8f\u6280\u672f\u62ef\u6551\u7684\u513f\u7ae5\u3002\u8fd9\u4e00\u5947\u8ff9\u7ed9\u4e86\u79d1\u5b66\u5bb6\u5de8\u5927\u7684\u4fe1\u5fc3\u3002<\/div>\n
\u00a0<\/div>\n
\u5f53\u4ed6\u8fd8\u8e52\u8dda\u5b66\u6b65\u65f6\uff0c\u5c31\u60a3\u4e0a\u4e86\u4e25\u91cd\u7684\u80a0\u9053\u611f\u67d3\u75c5\uff0c\u7ecf\u5386\u4e86\u7ea6\u767e\u6b21\u624b\u672f\uff0c\u5305\u62ec\u7ed3\u80a0\u79fb\u9664\uff0c\u6b7b\u4ea1\u4f3c\u4e4e\u5df2\u662f\u5b9a\u6570\u3002\u6ca1\u4eba\u5f04\u5f97\u6e05\u75c5\u56e0\uff0c\u5728\u8fd1\u4e4e\u7edd\u671b\u7684\u5bfb\u627e\u75c5\u56e0\u7684\u8fc7\u7a0b\u4e2d\uff0c\u5a01\u65af\u5eb7\u661f\u533b\u5b66\u9662\uff08Medical College of Wisconsin\uff09\u7684\u533b\u751f\u4eec\u505a\u4e86\u4e00\u4ef6\u524d\u536b\u7684\u3001\u53f2\u65e0\u524d\u4f8b\u7684\u4e8b\u60c5\uff1a\u5bf9\u6c83\u5c14\u514b\u7684DNA\u8fdb\u884c\u6d4b\u5e8f\u3002<\/div>\n
\u00a0<\/div>\n
\u6d4b\u5e8f\u7ed3\u679c\u53d1\u73b0\u4e86\u4e00\u4e2a\u51fa\u4eba\u610f\u6599\u7684\u57fa\u56e0\u7a81\u53d8\uff0c\u5b83\u80fd\u89e3\u91ca\u6c83\u5c14\u514b\u7684\u72b6\u51b5\uff0c\u800c\u4e14\u8fd8\u6307\u51fa\u4e86\u4e00\u79cd\u6cbb\u7597\u65b9\u6cd5\uff1a\u4ece\u8110\u5e26\u8840\u4e2d\u53d6\u51fa\u7ec6\u80de\u8fdb\u884c\u9aa8\u9ad3\u79fb\u690d\u3002<\/div>\n
\u00a0<\/div>\n
\u6cbb\u7597\u6548\u679c\u5f88\u597d\uff0c\u6c83\u5c14\u514b\u6210\u4e86DNA\u6280\u672f\u62ef\u6551\u751f\u547d\u7684\u9996\u4e2a\u6848\u4f8b\u3002\u867d\u7136\u4ecd\u9700\u670d\u7528\u836f\u7269\u4ee5\u9632\u79fb\u690d\u6392\u65a5\u53cd\u5e94\uff0c\u5e76\u4e14\u9700\u8981\u91cd\u5efa\u624b\u672f\uff0c\u4f46\u4ed6\u5df2\u7ecf\u80fd\u591f\u50cf\u5176\u4ed6\u5b69\u5b50\u4e00\u6837\u5f00\u5fc3\u7684\u5954\u8dd1\u4e86\u3002\u5bf9\u4e8e\u60a3\u6709\u7f55\u89c1\u3001\u96be\u4ee5\u786e\u8bca\u7684\u60a3\u8005\u800c\u8a00\uff0cDNA\u6d4b\u5e8f\u53ef\u80fd\u5c31\u662f\u6700\u540e\u7684\u6551\u547d\u529e\u6cd5\u3002<\/div>\n
\u00a0<\/div>\n
\u6c83\u5c14\u514b\u7684\u6848\u4f8b\u88ab\u53d1\u8868\u5728\u4e86\u300a\u9057\u4f20\u5b66\u53ca\u533b\u5b66\u300b\uff08Genetics and Medicine\uff09\u5b66\u672f\u671f\u520a\u4e0a\uff0c\u5e76\u4e14\u88ab\u300a\u5bc6\u5c14\u6c83\u57fa\u65b0\u95fb\u54e8\u5175\u62a5\u300b\uff08Milwaukee Journal Sentinel\uff09\u62a5\u9053\uff0c\u62a5\u9053\u8fd8\u8d62\u5f97\u4e86\u666e\u5229\u7b56\u65b0\u95fb\u5956\u3002\u6c83\u5c14\u514b\u548c\u4ed6\u7236\u6bcd\u4e5f\u56e0\u6b64\u53c2\u52a0\u4e86\u300a\u4eca\u65e5\u79c0\u300b\uff08Today Show\uff09\u3002<\/div>\n
\u00a0<\/div>\n
\u5e78\u8fd0\u7684\u4e0d\u6b62\u6709\u6c83\u5c14\u514b\uff0c\u8fd1\u5e74\u6765\u53c8\u6709\u591a\u4f4d\u5730\u4e2d\u6d77\u8d2b\u8840\u3001\u767d\u8840\u75c5\u60a3\u8005\u53d7\u76ca\u4e8e\u57fa\u56e0\u6280\u672f\u88ab\u5f7b\u5e95\u6cbb\u6108\u3002\u8fd9\u4e9b\u6fc0\u52a8\u4eba\u5fc3\u7684\u6210\u679c\u5411\u6211\u4eec\u5c55\u793a\u4e86\u201c\u57fa\u56e0\u79d1\u6280\u9020\u798f\u4eba\u7c7b\u201c\u7684\u8bf1\u4eba\u524d\u666f\u3002<\/div>\n
2015\u5e741\u670820\u65e5\uff0c\u65f6\u4efb\u7f8e\u56fd\u603b\u7edf\u5965\u5df4\u9a6c\u5728\u7b2c\u4e8c\u4efb\u671f\u7684\u9996\u4e2a\u56fd\u60c5\u54a8\u6587\u4e2d\u5c31\u6307\u51fa\uff1a\u201c\u6211\u4eec\uff08\u6307\u7f8e\u56fd\uff09\u5728\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u4e2d\u6bcf\u6295\u51651\u7f8e\u5143\uff0c\u5c31\u4f1a\u7ed9\u6211\u4eec\u7684\u7ecf\u6d4e\u5e26\u6765140\u7f8e\u5143\u7684\u56de\u62a5\u3002\u201d\uff0c\u5e76\u5ba3\u5e03\u65a5\u8d44\u542f\u52a8\u201c\u7cbe\u51c6\u533b\u7597\u8ba1\u5212\uff08Precision Medicine Initiative\uff09\u201d\u3002\uff08\u6ce8\uff1a\u540e\u6765HGP\u56de\u987e\u62a5\u544a\u663e\u793a\uff0c\u622a\u6b622014\u5e74\u7f8e\u56fd\u7684\u56de\u62a5\u7387\u4e3a1:178\uff09\u3002<\/div>\n\n
\n
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\u56fe\uff1a\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\uff08\u6765\u6e90\/\u4e92\u8054\u7f51\uff09<\/div>\n
\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u7684\u91cd\u8981\u7ecf\u9a8c<\/div>\n
\u4eca\u5929\uff0c\u5168\u7403\u8d8a\u6765\u8d8a\u591a\u5b66\u8005\u52a0\u5165\u57fa\u56e0\u9886\u57df\uff0c\u6b63\u5728\u52aa\u529b\u653b\u514b\u4e00\u4e9b\u524d\u8f88\u4eec\u60f3\u90fd\u6ca1\u60f3\u8fc7\u7684\u95ee\u9898\u3002\u6240\u6709\u53d6\u5f97\u7684\u6210\u529f\uff0c\u90fd\u7ee7\u627f\u5e76\u53d1\u626c\u4e86\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u7684\u56db\u6761\u91cd\u8981\u7ecf\u9a8c\u3002<\/div>\n
\u00a0<\/div>\n
\u7b2c\u4e00\uff0c\u901a\u529b\u534f\u540c\u5408\u4f5c<\/div>\n
\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u6253\u7834\u4e86\u7814\u7a76\u5b66\u8005\u72ec\u81ea\u63a2\u7d22\uff0c\u4e3a\u5c11\u6570\u51e0\u4e2a\u79d1\u5b66\u95ee\u9898\u5bfb\u6c42\u7b54\u6848\u7684\u683c\u5c40\uff0c\u8fd9\u662f\u52bf\u6240\u5fc5\u7136\u7684\u3002\u540c\u65f6\uff0c\u8fd8\u4e00\u53cd\u201c\u5047\u8bf4\u9a71\u52a8\u7814\u7a76\u201d\uff08Hypothesis-driven research\uff09\u7684\u79d1\u7814\u4f20\u7edf\uff0c\u800c\u662f\u57fa\u4e8e\u5927\u4eba\u7fa4\u548c\u6d77\u91cf\u6837\u672c\u3001\u6570\u636e\u5f00\u5c55\u7814\u7a76\u3002<\/div>\n
\u00a0<\/div>\n
\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u6c47\u96c6\u4e86\u6765\u81ea\u516d\u4e2a\u56fd\u5bb6\u3001\u591a\u79cd\u5b66\u79d1\u80cc\u666f\u3001\u4e0d\u540c\u8d44\u5386\u76842000\u591a\u540d\u7814\u7a76\u4eba\u5458\u3002\u4ed6\u4eec\u5206\u6210\u82e5\u5e72\u5c0f\u7ec4\uff0c\u7ecf\u8d39\u6765\u6e90\u591a\u79cd\u591a\u6837\uff0c\u4f46\u6700\u540e\u7684\u6210\u529f\u90fd\u6e90\u81ea\u51e0\u4e2a\u5171\u540c\u70b9\uff1a\u5404\u5c0f\u7ec4\u8d1f\u8d23\u4eba\u7684\u6709\u529b\u9886\u5bfc\u3001\u5bf9\u8fd9\u9879\u5de5\u4f5c\u91cd\u8981\u6027\u7684\u5171\u8bc6\u3001\u4ee5\u53ca\u7814\u7a76\u8005\u7518\u5fc3\u4e3a\u4e86\u5171\u540c\u5229\u76ca\u800c\u653e\u5f03\u4e2a\u4eba\u6210\u5c31\u7684\u610f\u613f\u3002<\/div>\n
\u00a0<\/div>\n
\u5176\u540e\u7684\u91cd\u5927\u57fa\u56e0\u7ec4\u5b66\u9879\u76ee\uff0c\u5305\u62ec\u201c\u5343\u4eba\u57fa\u56e0\u7ec4\u9879\u76ee\u201d\uff08the 1000 Genomes Project\uff09\uff0c\u9274\u5b9a\u81f4\u764c\u7a81\u53d8\u7684\u201c\u764c\u75c7\u57fa\u56e0\u7ec4\u56fe\u8c31\u9879\u76ee\u201d\uff08Cancer Genome Atlas\uff09\uff0c\u4ee5\u53ca\u201c\u4eba\u7c7b\u5fae\u751f\u7269\u7ec4\u8ba1\u5212\u201d\uff08Human Microbiome Project\uff09\uff0c\u90fd\u7ee7\u627f\u548c\u53d1\u626c\u4e86\u8fd9\u4e2a\u4f18\u79c0\u4f20\u7edf\u3002<\/div>\n
\u65b0\u51a0\u75ab\u60c5\uff0c\u8ba9\u5404\u56fd\u65c5\u884c\u53d8\u5f97\u4e0d\u6613\uff0c\u66f4\u52a0\u9700\u8981\u5f3a\u8c03\u5927\u79d1\u5b66\u7814\u7a76\u4e2d\u5f00\u653e\u5408\u4f5c\u7684\u91cd\u8981\u6027\u3002<\/div>\n
\u00a0<\/div>\n
\u7b2c\u4e8c\uff0c\u6570\u636e\u5f00\u653e\u5206\u4eab<\/div>\n
\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u6539\u53d8\u4e86\u751f\u7269\u533b\u5b66\u7814\u7a76\u4e2d\u6570\u636e\u5206\u4eab\u7684\u65e7\u5386\u30021996\u5e74\uff0c\u767e\u6155\u5927\u539f\u5219\uff08Bermuda Principles\uff09\u7684\u5b9e\u65bd\u4e3a\u8fd9\u4e00\u756a\u52aa\u529b\u753b\u4e0a\u4e86\u53e5\u70b9\u3002<\/div>\n
\u00a0<\/div>\n
\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u4e3b\u8981\u9886\u5bfc\u4eba\u540c\u610f\u5728\u57fa\u56e0\u5e8f\u5217\u751f\u6210\u540e\u768424\u5c0f\u65f6\u5185\uff0c\u5c06\u8fbe\u5230\u4e00\u5b9a\u89c4\u6a21\u7684\u57fa\u56e0\u7ec4\u5e8f\u5217\u6574\u5408\u63d0\u4ea4\u5230\u4e00\u4e2a\u516c\u5171\u6570\u636e\u5e93\u30022014\u5e74\uff0c\u4e00\u9879\u5168\u9762\u7684\u201c\u57fa\u56e0\u7ec4\u6570\u636e\u5206\u4eab\u653f\u7b56\u201d\uff08Genomic Data Sharing Policy\uff09\u5f00\u59cb\u5b9e\u65bd\uff0c\u8981\u6c42\u51e0\u4e4e\u6240\u6709\u5728NIH\uff08\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u9662\uff09\u57fa\u91d1\u8d44\u52a9\u4e0b\u83b7\u5f97\u6216\u5206\u6790\u7684\u57fa\u56e0\u7ec4\u6570\u636e\u90fd\u5fc5\u987b\u62ff\u51fa\u6765\u5171\u4eab\u3002<\/div>\n
\u00a0<\/div>\n
\u4eba\u7c7b\u57fa\u56e0\u6570\u636e\u7684\u5206\u4eab\u4e5f\u5e26\u6765\u4e86\u65b0\u6311\u6218\uff0c\u4eba\u4eec\u6b63\u5728\u63a2\u7d22\u65b0\u65b9\u6848\u4ee5\u89e3\u51b3\u4e0d\u65ad\u51fa\u73b0\u7684\u65b0\u95ee\u9898\uff0c\u5305\u62ec\u6d77\u91cf\u6570\u636e\u5728\u8ba1\u7b97\u3001\u4f20\u8f93\u4e0a\u7684\u96be\u9898\uff0c\u4ee5\u53ca\u5982\u4f55\u4fdd\u62a4\u7814\u7a76\u4e2d\u88ab\u8bd5\u8005\u7684\u9690\u79c1\u3002<\/div>\n
\u00a0<\/div>\n
\u7b2c\u4e09\uff0c\u4f18\u5148\u6280\u672f\u53d1\u5c55<\/div>\n
1990\u5e74\uff0c\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u521a\u4e00\u542f\u52a8\uff0c\u6838\u5fc3\u79d1\u5b66\u5bb6\u5c31\u6e05\u9192\u5730\u8ba4\u8bc6\u5230\uff0c\u5fc5\u987b\u628a\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u4e0e\u7ed8\u5236\u56fe\u8c31\u7684\u5de5\u5177\u4e0e\u65b9\u6cd5\u4f5c\u4e3a\u4e00\u4e2a\u66f4\u5927\u7684\u9879\u76ee\u53bb\u5f00\u53d1\u3002<\/div>\n
\u00a0<\/div>\n
\u4ed6\u4eec\u628a\u591a\u79cd\u6e10\u8fdb\u6027\u7684\u6280\u672f\u521b\u65b0\u6574\u5408\u5728\u4e00\u8d77\uff0c\u53d6\u5f97\u4e86\u9769\u547d\u6027\u7684\u8fdb\u6b65\uff0c\u4ece\u6bdb\u7ec6\u7ba1\u7535\u6cf3\u6cd5\u5230\u6851\u683cDNA \u6d4b\u5e8f\u6cd5\u5c31\u662f\u4e00\u4e2a\u6781\u597d\u7684\u4f8b\u8bc1\uff0cDNA\u6d4b\u5e8f\u6cd5\u6700\u7ec8\u6210\u4e3a\u7ed8\u5236\u4eba\u7c7b\u9996\u4e2a\u57fa\u56e0\u7ec4\u56fe\u8c31\u7684\u5173\u952e\u6280\u672f\u3002\u5de5\u5177\u548c\u6280\u672f\u4e0d\u65ad\u521b\u65b0\u7684\u540c\u65f6\uff0c\u8be5\u8ba1\u5212\u4e5f\u50ac\u751f\u4e86\u65e0\u6570\u7684\u9057\u4f20\u5b66\u6280\u672f\uff0c\u5e76\u5f15\u53d1\u4e86\u5206\u5b50\u751f\u7269\u5b66\u3001\u5316\u5b66\u3001\u7269\u7406\u5b66\u548c\u8ba1\u7b97\u79d1\u5b66\u7684\u91cd\u5927\u9769\u65b0\u3002<\/div>\n
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\u00a0<\/div>\n
\u7b2c\u56db\uff0c\u98a0\u8986\u4f20\u7edf\u7684\u79d1\u7814\u6a21\u5f0f<\/div>\n
\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u4ece\u6839\u672c\u4e0a\u5f15\u53d1\u4e86\u7814\u7a76\u65b9\u5f0f\u7684\u53d8\u9769\uff0c\u751a\u81f3\u53ef\u4ee5\u8bf4\u662f\u4e00\u573a\u79d1\u7814\u65b9\u5f0f\u7684\u9769\u547d\u3002\u8fc7\u53bb\u4e3b\u6d41\u7684\u7814\u7a76\u65b9\u5f0f\u662fPI\u5236\u4e0b\u7684\u5047\u8bbe\u9a71\u52a8\u7814\u7a76\uff08Hypothesis-driven research\uff09\u3010\u6ce8\uff1aPI \u5236\u5373Principal Investigator\uff0c\u6307\u4e2a\u4f53\u62e5\u6709\u4e3b\u5bfc\u6743\u548c\u6307\u5bfc\u6743\u3011\uff0c\u8be5\u8ba1\u5212\u63a8\u52a8\u8f6c\u53d8\u4e3a\u5927\u6570\u636e\u9a71\u52a8\u7684\u65b0\u578b\u79d1\u7814\u6a21\u5f0f\uff08big-data-driven research\uff09\uff0c\u4e5f\u5c31\u662f\u79d1\u5b66\u7814\u7a76\u4ece\u201c\u5c0f\u79d1\u5b66\u201d\u771f\u6b63\u8d70\u5230\u4e86\u201c\u5927\u79d1\u5b66\u201d\u3002<\/div>\n
\u00a0<\/div>\n
\u76f4\u5230\u73b0\u5728\uff0c\u7edd\u5927\u90e8\u5206\u4eba\uff0c\u5305\u62ec\u79d1\u5b66\u5bb6\uff0c\u4f9d\u7136\u672a\u80fd\u7406\u89e3\u548c\u63a5\u53d7\u8fd9\u4e00\u53d8\u9769\u7684\u91cd\u8981\u6027\u548c\u6df1\u8fdc\u610f\u4e49\u3002<\/div>\n
\u00a0<\/div>\n
\u65e0\u8bba\u662f\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u7684\u9886\u5bfc\u8005\uff08\u8bfa\u8d1d\u5c14\u5956\u83b7\u5f97\u8005\u8a79\u59c6\u65af\u00b7\u6c83\u68ee\u4e0e\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u9662\u4e3b\u4efb\u5f17\u6717\u897f\u65af\u00b7\u67ef\u6797\u65af\uff09\uff0c\u8fd8\u662f\u5177\u4f53\u6267\u884c\u9879\u76ee\u7684\u79d1\u5b66\u5bb6\u4eec\uff0c\u4ed6\u4eec\u6050\u6015\u90fd\u672a\u9884\u89c1\u5230\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u7684\u4e3b\u8981\u6536\u83b7\uff0c\u5c45\u7136\u662f\u65b0\u578b\u7684\u79d1\u7814\u6a21\u5f0f\u3002<\/div>\n
\u00a0<\/div>\n
\u5728\u8fd9\u4e00\u65b0\u578b\u79d1\u7814\u6a21\u5f0f\u63a8\u52a8\u4e0b\uff0c\u6570\u5343\u79cd\u75be\u75c5\u81f4\u75c5\u673a\u7406\u7684\u53d1\u73b0\u3001\u764c\u75c7\u7684\u91cd\u65b0\u5b9a\u4e49\u548c\u7cbe\u51c6\u4e2a\u4f53\u5316\u6cbb\u7597\u3001\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u548c\u5e72\u7ec6\u80de\u6cbb\u7597\u7684\u5e94\u7528\u7b49\uff0c\u4e00\u7cfb\u5217\u8ba9\u4eba\u773c\u82b1\u7f2d\u4e71\u7684\u751f\u7269\u533b\u5b66\u6210\u5c31\u628a\u4eba\u7c7b\u5e26\u5165\u4e86\u4e00\u4e2a\u5168\u65b0\u7684\u4e16\u754c\u3002<\/div>\n
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\u00a0<\/div>\n
\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u7684\u91cd\u8981\u7ecf\u9a8c<\/div>\n
\u672a\u6765\u4e8c\u4e09\u5341\u5e74\uff0c\u8fd9\u4e00\u4ece\u201c\u79d1\u6280\u521b\u65b0\u201d\u5230\u201c\u521b\u65b0\u79d1\u6280\u201d\u7684\u8303\u5f0f\u8f6c\u79fb\uff0c\u5c06\u4f1a\u5411\u4eba\u7c7b\u5c55\u793a\u5b83\u65e0\u4ee5\u4f26\u6bd4\u3001\u4ee4\u4eba\u60ca\u53f9\u7684\u9b45\u529b\u3002<\/div>\n
\u00a0<\/div>\n
\u201c\u79d1\u6280-\u4ea7\u4e1a-\u6c11\u751f\u201d\u4e09\u8005\u8054\u52a8\u7684\u201c\u98de\u8f6e\u6a21\u5f0f\u201d\uff0c\u5c06\u5e26\u7ed9\u4e16\u754c\u524d\u6240\u672a\u6709\u7684\u8fdb\u6b65\u3002\u79d1\u6280\u7814\u53d1\u3001\u4ea7\u4e1a\u53d1\u5c55\u3001\u6c11\u751f\u798f\u7949\u7684\u5168\u9762\u5b9e\u73b0\u53ef\u80fd\u5c06\u8d85\u8d8a\u6587\u827a\u590d\u5174\u65f6\u671f\uff0c\u63a8\u52a8\u4eba\u7c7b\u521b\u9020\u66f4\u7480\u74a8\u3001\u66f4\u8f89\u714c\u7684\u6587\u660e\u3002<\/div>\n
\u4e5f\u8bb8\u4f60\u5bf9\u6b64\u5c06\u4fe1\u5c06\u7591\uff0c\u4f46\u5b83\u7ec8\u4f1a\u4e00\u4e00\u5151\u73b0\u3002<\/div>\n
\u00a0<\/div>\n
\u53c2\u8003\u8d44\u6599\uff1a<\/div>\n
1.\u00a0The First Child Saved By DNA Sequencing\uff0c\u300aForbes\u300b\uff0c2011\u5e741\u67085\u65e5 https:\/\/www.forbes.com\/sites\/matthewherper\/2011\/01\/05\/the-first-child-saved-by-dna-sequencing\/?sh=29ab4ad037c0\u00a0<\/div>\n
2. \u300aNature:\u56de\u987e\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u768425\u5e74\u300b\uff0cEric D. Green\u00a0 James D. Watson Francis S. Collins<\/div>\n
\u00a0<\/div>\n
\u63a8\u8350\u9605\u8bfb<\/div>\n
Science\u5c01\u9762\u7eaa\u5ff5\u4eba\u7c7b\u57fa\u56e0\u7ec4\u5de5\u4f5c\u8349\u56fe\u7ed8\u5236\u5b8c\u621020\u5468\u5e74<\/a><\/div>\n
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