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\uff08\u6765\u6e90\/Science)<\/div>\n
\u5b8f\u89c2\u73af\u5883<\/div>\n
\u2756\u00a0\u300a2020\u5e74\u653f\u5e9c\u5de5\u4f5c\u62a5\u544a\u300b\u53d1\u5e03<\/div>\n
2021\u5e743\u67085\u65e5\uff0c\u653f\u5e9c\u5de5\u4f5c\u62a5\u544a\u53d1\u5e03\u3002\u62a5\u544a\u6307\u51fa\uff1a<\/div>\n
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3\uff09\u4eca\u5e74\u4e3b\u8981\u76ee\u6807\uff1a\u56fd\u5185\u751f\u4ea7\u603b\u503c\u589e\u957f6%\u4ee5\u4e0a\uff1b\u57ce\u9547\u65b0\u589e\u5c31\u4e1a1100\u4e07\u4eba\u4ee5\u4e0a\uff1b\u5c45\u6c11\u6d88\u8d39\u4ef7\u683c\u6da8\u5e453%\u5de6\u53f3\uff1b\u5355\u4f4d\u56fd\u5185\u751f\u4ea7\u603b\u503c\u80fd\u8017\u964d\u4f4e3%\u5de6\u53f3\uff1b\u7cae\u98df\u4ea7\u91cf\u4fdd\u6301\u57281.3\u4e07\u4ebf\u65a4\u4ee5\u4e0a\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>\uff08\u62a5\u544a\u5168\u6587\uff09<\/div>\n
http:\/\/www.gov.cn\/zhuanti\/2020qglh\/2020zfgzbgdzs\/2020zfgzbgdzs.html<\/div>\n
\u00a0<\/div>\n
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\u00a0<\/div>\n
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2021\u5e742\u670822\u65e5,\u300a\u6559\u80b2\u90e8\u529e\u516c\u5385\u5173\u4e8e\u516c\u5e032020\u5e74\u5ea6\u56fd\u5bb6\u7ea7\u548c\u7701\u7ea7\u4e00\u6d41\u672c\u79d1\u4e13\u4e1a\u5efa\u8bbe\u70b9\u540d\u5355\u7684\u901a\u77e5\u300b(\u6559\u9ad8\u5385\u51fd\u30142021\u30157\u53f7)\u53d1\u5e03\u3002\u591a\u4e2a\u9ad8\u6821\u7684\u751f\u7269\u6280\u672f\/\u751f\u7269\u4fe1\u606f\u5b66\u4e13\u4e1a\u5165\u9009\u56fd\u5bb6\u7ea7\u4e00\u6d41\u672c\u79d1\u4e13\u4e1a\u5efa\u8bbe\u70b9\uff0c\u4f8b\u5982\u5357\u4eac\u533b\u79d1\u5927\u5b66\u7684\u751f\u7269\u4fe1\u606f\u5b66\u4e13\u4e1a\u3001\u5b81\u6ce2\u5927\u5b66\u7684\u751f\u7269\u6280\u672f\u4e13\u4e1a\u7b49\u3002<\/div>\n
\u00a0<\/div>\n
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\u00a0<\/div>\n
\u6700\u65b0\u4ea7\u54c1<\/div>\n
\u2756\u00a0Illumina\u65d7\u4e0bNextSeq 550Dx\u6d4b\u5e8f\u5e73\u53f0\u5728\u4fc4\u83b7\u6279<\/div>\n
2021\u5e743\u67085\u65e5\uff0cIllumina\u8868\u793a\uff0c\u65d7\u4e0bNextSeq 550Dx\u6d4b\u5e8f\u5e73\u53f0\u53ca\u5176\u914d\u5957\u8bd5\u5242\u76d2\uff0c\u83b7\u5f97\u4fc4\u7f57\u65af\u5f53\u5c40\u533b\u7597\u8bbe\u5907\u6ce8\u518c\u6279\u51c6\u3002\u53bb\u5e7412\u6708\uff0c\u6211\u56fdNMPA\u6279\u51c6\u4e86Illumina\u65d7\u4e0b\u7684NextSeq 550Dx\u7528\u4e8e\u57fa\u56e0\u68c0\u6d4b\u548c\u4e34\u5e8a\u8bca\u65ad\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0Rebus Biosystems\u53d1\u5e03\u81ea\u52a8\u5316\u7a7a\u95f4\u7ec4\u5b66\u5e73\u53f0<\/div>\n
2021\u5e743\u67081\u65e5\uff0c\u751f\u547d\u79d1\u6280\u516c\u53f8Rebus Biosystems\u5728AGBT\u7ebf\u4e0a\u4f1a\u8bae\u53d1\u5e03\u7a7a\u95f4\u7ec4\u5b66\u5e73\u53f0Rebus Esper\u3002\u636eRebus CEO\u516c\u5f00\u4ecb\u7ecd\uff0cRebus Esper\u5e73\u53f0\u662f\u5b8c\u5168\u96c6\u6210\u7684\u81ea\u52a8\u5316\u4eea\u5668\uff0c\u63d0\u4f9b\u5177\u6709\u7a7a\u95f4\u80cc\u666f\u548c\u4e9a\u7ec6\u80de\u5206\u8fa8\u7387\u7684\u9ad8\u901a\u91cf\u3001\u5b9a\u91cf\u3001\u5355\u5206\u5b50\u3001\u5355\u7ec6\u80de\u6570\u636e\u548c\u751f\u7269\u4fe1\u606f\u5b66\uff0c\u4e0d\u9700\u8981\u6210\u50cf\u6216\u56fe\u50cf\u5904\u7406\u7ecf\u9a8c\u3002\u51c6\u5907\u8fd0\u884c\u9075\u5faa\u4e00\u4e2a\u7b80\u5355\u7684\u534f\u8bae\uff0c\u5728\u4e0d\u5230\u4e00\u5c0f\u65f6\u7b80\u5355\u4eba\u5de5\u51c6\u5907\u5de5\u4f5c\u540e\uff0c\u4eea\u5668\u81ea\u52a8\u8fd0\u884c\u5e76\u8fd4\u56de\u7528\u4e8e\u5355\u7ec6\u80de\u5206\u6790\u548c\u7cbe\u786e\u7684\u7a7a\u95f4\u6620\u5c04\u7684\u6570\u636e\u3002<\/div>\n\n
\n
\"0?wx_fmt=png\"\/<\/figure><\/div>\n\n
\u56fe\uff1aRebus Esper\u5e73\u53f0\uff08\u6765\u6e90\/BioWorld)<\/div>\n
\u2756\u00a0\u56fd\u5185\u9996\u6b3e\u4e13\u6ce8\u7ed3\u76f4\u80a0\u764c\u7684NGS\u4f34\u968f\u8bca\u65ad\u8bd5\u5242\u76d2\u83b7\u6279<\/div>\n
2021\u5e743\u67083\u65e5\uff0c\u6839\u636e\u81fb\u548c\u57fa\u56e0\u516c\u5f00\u6d88\u606f\uff0c\u7531\u65e0\u9521\u81fb\u548c\u751f\u7269\u79d1\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u7ed3\u76f4\u80a0\u764cNGS\u591a\u57fa\u56e0\u8054\u5408\u68c0\u6d4b\u4ea7\u54c1\u201c\u4ebaKRAS\/NRAS\/BRAF\/PIK3CA\u57fa\u56e0\u7a81\u53d8\u8054\u5408\u68c0\u6d4b\u8bd5\u5242\u76d2\uff08\u53ef\u9006\u672b\u7aef\u7ec8\u6b62\u6d4b\u5e8f\u6cd5\uff09\u201d\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u4e09\u7c7b\u533b\u7597\u5668\u68b0\u6ce8\u518c\u8bc1\uff08\u56fd\u68b0\u6ce8\u51c620213400151\uff09\u3002\u8fd9\u662f\u56fd\u5185\u9996\u6b3e\u4e13\u6ce8\u4e8e\u7ed3\u76f4\u80a0\u764c\u7684NGS\u4f34\u968f\u8bca\u65ad\u8bd5\u5242\u76d2\u3002<\/div>\n
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\n
\"RmFicvQBAkgAPaJMHaiaWEuVcGia3yvXhZOoaj9cMia4jxGMnG2RaNK3UBO38qGiaQupNEENUUV96jQ3b1qenzLApQw\"\/<\/figure><\/div>\n\n
\u524d\u6cbf\u6280\u672f<\/div>\n
\u2756 Nature\uff1a\u53d1\u73b0\u5019\u9e1f\u7fa4\u4f53\u8fc1\u5f99\u80cc\u540e\u7684\u5173\u8054\u57fa\u56e0ADCY8<\/div>\n
2021\u5e743\u67084\u65e5\uff0c\u6211\u56fd\u79d1\u5b66\u5bb6\u5728Nature\u53d1\u8868\u7814\u7a76\u6210\u679c\uff0c\u901a\u8fc7\u4f7f\u7528\u7ed1\u5728\u9e1f\u80cc\u4e0a\u7684\u536b\u661f\u8ffd\u8e2a\u8bbe\u5907\uff0c\u5728\u8fc7\u53bb\u7684\u51e0\u5e74\u4e2d\u8ffd\u8e2a\u4e8656\u53ea\u9e1f\uff0c\u786e\u5b9a\u4e86\u6765\u81ea6\u4e2a\u4e0d\u540c\u5317\u6781\u7e41\u6b96\u79cd\u7fa4\u7684150\u6761\u5b8c\u6574\u7684\u8fc1\u5f99\u8def\u7ebf\u3002\u901a\u8fc7\u5bf9\u5176\u4e2d35\u53ea\u9e1f\u7684\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\uff0c\u53d1\u73b0ADCY8\u57fa\u56e0\u53ef\u80fd\u5728\u534f\u52a9\u730e\u9e70\uff08peregrine falcons\uff09\u7684\u8fc1\u5f99\u884c\u4e3a\u4e2d\u53d1\u6325\u4f5c\u7528\uff0c\u4e14\u8be5\u7279\u5b9a\u57fa\u56e0\u5728\u4e0d\u540c\u79cd\u7fa4\u4e4b\u95f4\u5dee\u5f02\u5316\u8f83\u5927\uff0c\u53ef\u80fd\u7531\u4e8e\u67d0\u79cd\u81ea\u7136\u9009\u62e9\uff0c\u8be5\u57fa\u56e0\u5728\u529f\u80fd\u4e0a\u4e5f\u53ef\u80fd\u6709\u52a9\u4e8e\u957f\u671f\u8bb0\u5fc6\u3002<\/div>\n
\u00a0<\/div>\n
\u2756 Science\uff1a\u539f\u4f4d\u57fa\u56e0\u7ec4\u6d4b\u5e8f\uff0c\u6d4b\u5e8f\u540c\u65f6\u5bf9\u7ec6\u80de\u5185\u7a7a\u95f4\u5173\u7cfb\u6210\u50cf<\/div>\n
\u8fd1\u65e5\uff0cMIT\u548cBroad\u7b49\u591a\u5bb6\u673a\u6784\u5b66\u8005\u5728Science\u53d1\u5e03\u4e86\u7814\u7a76\u6210\u679c\uff0c\u5728\u539f\u4f4d\u5355\u7ec6\u80de\u4e2d\u5f00\u53d1\u4e86\u4e00\u79cd\u65e0\u504f\u89c1\u7684\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6280\u672f\uff0c\u5728\u5b8c\u6574\u7684\u5355\u4e2a\u7ec6\u80de\u4e2d\u4ee5\u4e9a\u5fae\u7c73\u5206\u8fa8\u7387\u7ed8\u5236\u548c\u6210\u50cf\u57fa\u56e0\u7ec4\u5750\u6807\uff0c\u901a\u8fc7\u6210\u50cf\u63a8\u65ad\u67d3\u8272\u8d28\u7684\u7ed3\u6784\uff0c\u9274\u5b9a\u4e9a\u6838\u4f4d\u7f6e\u7684\u5e8f\u5217\u3002<\/div>\n\n
\n
\"RmFicvQBAkgAPaJMHaiaWEuVcGia3yvXhZOu4rlGjrRQ0ddaWHPZrev9iaMNVmxHtk7ZLuIeuGP0N0dwAI8xNiaEzqg\"\/<\/figure><\/div>\n\n
\u56fe\uff1a\u539f\u4f4d\u57fa\u56e0\u7ec4\u6d4b\u5e8f\uff08\u6765\u6e90\/Science)<\/div>\n
\u2756 PNAS\uff1a\u8c22\u6653\u4eae\u56e2\u961f\u5728\u5355\u7ec6\u80de\u6c34\u5e73\u5b9e\u73b0SNV \u7cbe\u786e\u68c0\u6d4b\u7684\u5168\u57fa\u56e0\u7ec4\u6269\u589e\u65b9\u6cd5<\/div>\n
2021\u5e742\u670823\u65e5\uff0c\u5317\u4eac\u5927\u5b66\u8c22\u6653\u4eae\u56e2\u961f\u5728\u7f8e\u56fd\u79d1\u5b66\u9662\u9662\u520aPNAS\u53d1\u8868\u4e00\u79cd\u5355\u7ec6\u80de\u5168\u57fa\u56e0\u7ec4\u6269\u589e\u65b9\u6cd5META-CS\uff0c\u80fd\u591f\u5728\u5355\u7ba1\u53cd\u5e94\u4e2d\u5206\u522b\u6807\u8bb0\u548c\u6269\u589e\u4e24\u6761DNA\u94fe\uff0c\u51e0\u4e4e\u6d88\u9664\u4e86\u7531\u4e8e\u7ec6\u80de\u5185\u5355\u94feDNA\u635f\u4f24\u548c\u5168\u57fa\u56e0\u7ec4\u6269\u589e\u8fc7\u7a0b\u7684\u5f71\u54cd\u5e26\u6765\u5355\u7ec6\u80deSNVs\uff08\u4f53\u7ec6\u80de\u7a81\u53d8\uff09\u68c0\u6d4b\u7684\u5047\u9633\u6027\u95ee\u9898\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/www.pnas.org\/content\/118\/8\/e2013106118<\/div>\n
\u00a0<\/div>\n
\u2756 Science\uff1a\u901a\u8fc7\u57fa\u56e0\u7f16\u8f91\u751f\u4ea7\u9a6f\u5316\u591a\u500d\u4f53\u6c34\u7a3b<\/div>\n
2021\u5e743\u67085\u65e5\uff0cScience\u53d1\u6587\uff0c\u5c55\u793a\u4e86Yu\u7b49\u4eba\u901a\u8fc7\u57fa\u56e0\u7f16\u8f91\u751f\u4ea7\u9a6f\u5316\u591a\u500d\u4f53\u6c34\u7a3b\u7684\u65b9\u6cd5\u3002\u7814\u7a76\u8005\u4ece\u4e00\u4e2a\u9065\u8fdc\u5bb6\u7cfb\u7684\u91ce\u751f\u7a3b\uff08O. sativa\uff09\u548c\u82b8\u8c46\uff08O. rufipogon\uff09\u7684\u591a\u500d\u4f53\u8868\u4eb2\u5f00\u59cb\uff0c\u9009\u62e9\u5229\u4e8e\u57fa\u56e0\u7f16\u8f91\u548c\u519c\u4f5c\u7269\u751f\u4ea7\u7684\u7279\u6027\u7684\u91ce\u751f\u83cc\u682a\uff0c\u901a\u8fc7\u57fa\u56e0\u7ec4\u5206\u6790\u548c\u65b9\u6cd5\u4f18\u5316\uff0c\u5728\u65b0\u4f5c\u7269\u63a8\u5e7f\u79cd\u690d\u8bc4\u4f30\u4e4b\u524d\u8fdb\u884c\u57fa\u56e0\u7ec4\u7f16\u8f91\u3001\u5e38\u89c4\u6742\u4ea4\u548c\u6d4b\u8bd5\u5f80\u590d\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/www.nature.com\/articles\/d41586-021-00589-9#ref-CR1<\/div>\n\n
\n
\"RmFicvQBAkgAPaJMHaiaWEuVcGia3yvXhZOJazb6yc2icrqoOj9fyrylYxptNlEgkL3SQN6dItDloSUS1ctW1yK5bg\"\/<\/figure><\/div>\n\n
\u56fe\uff1a\u901a\u8fc7\u57fa\u56e0\u7f16\u8f91\u751f\u4ea7\u9a6f\u5316\u591a\u500d\u4f53\u6c34\u7a3b\u8def\u7ebf\u56fe<\/div>\n
\uff08\u6765\u6e90\/Science)<\/div>\n
\u00a0<\/div>\n
\u2756 Cell\uff1a\u57fa\u56e0\u548c\u73af\u5883\u5bf9\u80a5\u80d6\u548cII\u578b\u7cd6\u5c3f\u75c5\u7684\u7efc\u5408\u5f71\u54cd<\/div>\n
2021\u5e743\u67085\u65e5\uff0cCell\u53d1\u5e03\u7efc\u8ff0\u6587\u7ae0\uff0c\u9610\u8ff0\u4e86\u5bf9\u4e8e\u80a5\u80d6\u548cII\u578b\u7cd6\u5c3f\u75c5\uff0c\u5f71\u54cd\u4ee3\u8c22\u7684\u9057\u4f20\u56e0\u7d20\u548c\u73af\u5883\u56e0\u7d20\u6709\u5173\u7684\u6700\u65b0\u7814\u7a76\u8fdb\u5c55\u548c\u65b0\u5174\u601d\u60f3\u3002\u91cd\u70b9\u4ecb\u7ecd\u4e86\u8f6c\u5316\u7814\u7a76\u548c\u4e34\u5e8a\u5e94\u7528\uff0c\u5305\u62ecCOVID-19\u5927\u6d41\u884c\u7684\u5f71\u54cd\uff0c\u4ee5\u53ca\u5c55\u671b\u672a\u6765\u5fc5\u987b\u91c7\u53d6\u4e2a\u6027\u5316\u9884\u9632\u3001\u7ba1\u7406\u548c\u62a4\u7406\u5404\u4e2a\u65b9\u9762\u7684\u7b56\u7565\uff0c\u4ece\u800c\u6539\u5584\u5065\u5eb7\u72b6\u51b5\u5e76\u51cf\u5c11\u8fd9\u4e9b\u4ee3\u8c22\u6027\u75be\u75c5\u7684\u5f71\u54cd\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(21)00162-8<\/div>\n\n
\n
\"RmFicvQBAkgAPaJMHaiaWEuVcGia3yvXhZOXznZS22lLCtf15qdwJgnxDK9AI4iaxAQa7RIZNB1sIWRSf3dNf7ibshA\"\/<\/figure><\/div>\n\n
\u56fe\uff1a\u73af\u5883\u548c\u57fa\u56e0\u5bf9\u80a5\u80d6\u548cII\u578b\u7cd6\u5c3f\u75c5\u7684\u7efc\u5408\u5f71\u54cd<\/div>\n
\uff08\u6765\u6e90\/Cell)<\/div>\n
\u2756 \u56fd\u5bb6\u536b\u5065\u59d4\u4e34\u68c0\u4e2d\u5fc3\u56e2\u961f\u53d1\u8868NGS\u80bf\u7624\u7a81\u53d8\u6570\u636e\u96c6\u6a21\u62df\u8f6f\u4ef6<\/div>\n
\u8fd1\u65e5\uff0c\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u4e34\u5e8a\u68c0\u9a8c\u4e2d\u5fc3\u7684\u674e\u91d1\u660e\u56e2\u961f\u3001\u4e2d\u56fd\u79d1\u5b66\u9662\u8ba1\u7b97\u6280\u672f\u7814\u7a76\u6240\u7684\u8d75\u5c79\u56e2\u961f\u7b49\u5408\u4f5c\u5f00\u53d1\u4e86\u80bf\u7624\u7a81\u53d8\u6570\u636e\u6a21\u62df\u8f6f\u4ef6VarBen\u3002\u7814\u7a76\u6210\u679c\u53d1\u8868\u5728\u56fd\u9645\u5206\u5b50\u8bca\u65ad\u9886\u57df\u6743\u5a01\u671f\u520a The Journal of Molecular Diagnostics\u4e0a\u3002\u8be5\u8f6f\u4ef6\u89e3\u51b3\u4e86\u76ee\u524d\u73b0\u6709\u8f6f\u4ef6\u65e0\u6cd5\u5bf9\u9776\u5411panel\u6d4b\u5e8f\u6570\u636e\u7684\u62f7\u8d1d\u6570\u53d8\u5f02\u3001\u5927\u7247\u6bb5\u7ed3\u6784\u53d8\u5f02\u4ee5\u53ca\u590d\u6742\u63d2\u5165\/\u7f3a\u5931\u53d8\u5f02\u7b49\u8fdb\u884c\u6a21\u62df\u7684\u96be\u9898\u3002\u540c\u65f6\uff0c\u8be5\u8f6f\u4ef6\u652f\u6301\u76ee\u524d\u4e34\u5e8a\u4e0a\u5e38\u7528\u7684\u6d4b\u5e8f\u5e73\u53f0\uff0c\u5305\u62ecIllumina\u3001\u534e\u5927\u667a\u9020\u4ee5\u53caIon torrent\u6d4b\u5e8f\u5e73\u53f0\u3002<\/div>\n
\u00a0<\/div>\n
\u2756 Nature \uff1a\u00a0\u5e7f\u5dde\u5065\u5eb7\u9662\u53d1\u73b0RNA\u8c03\u63a7\u67d3\u8272\u8d28\u7684\u65b0\u673a\u5236<\/div>\n
2021\u5e743\u67084\u65e5\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u5e7f\u5dde\u751f\u7269\u533b\u836f\u4e0e\u5065\u5eb7\u7814\u7a76\u9662\u5728Nature\u53d1\u8868\u7814\u7a76\u6210\u679c\u3002\u9648\u6377\u51ef\u8bfe\u9898\u7ec4\u53d1\u73b0\u4e86RNA m6A\u4fee\u9970\u8c03\u63a7\u5f02\u67d3\u8272\u8d28\u5f62\u6210\u7684\u65b0\u673a\u5236\uff0c\u9610\u660eRNA m6A\u9605\u8bfb\u5668YTHDC1\u5728\u8fd9\u4e00\u673a\u5236\u4e2d\u7684\u5173\u952e\u4f5c\u7528\uff1a\u6291\u5236\u57fa\u56e0\u7ec4\u4e2d\u5e7f\u6cdb\u5206\u5e03\u7684ERVK\u3001IAP\u3001LINE1\u7b49\u8f6c\u5ea7\u5143\u4ef6\uff0c\u9650\u5236\u80da\u80ce\u5e72\u7ec6\u80de\u5411\u5168\u80fd\u6027\u5e72\u7ec6\u80de\u8f6c\u5316\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/www.nature.com\/articles\/s41586-021-03313-9<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0Molecular Cancer\uff1a\u6f5c\u5728\u7684\u514d\u75ab\u6cbb\u7597\u751f\u7269\u6807\u5fd7\u7269ITH<\/div>\n
2021\u5e742\u670823\u65e5\uff0c\u5f20\u529b\u6559\u6388\u3001\u65b9\u6587\u5cf0\u6559\u6388\u56e2\u961f\u4e0e\u88d5\u7b56\u751f\u7269\u5408\u4f5c\u7684\u6700\u65b0\u7814\u7a76\u6210\u679c\u5728Molecular Cancer\u4e0a\u53d1\u5e03\u3002\u8fd9\u662f\u9996\u6b21\u5728\u6cdb\u764c\u79cd\u6c34\u5e73\u4e0a\u53d1\u73b0ITH\uff08\u7624\u5185\u5f02\u8d28\u6027\uff09\u4e2d\u4f4d\u503c\u4e0e\u514d\u75ab\u6cbb\u7597\u7597\u6548\u4e4b\u95f4\u5b58\u5728\u76f8\u5173\u6027\u3002\u7814\u7a76\u53d1\u73b0ITH \u662f\u6f5c\u5728\u7684\u514d\u75ab\u6cbb\u7597\u751f\u7269\u6807\u5fd7\u7269\uff0c\u53ef\u9884\u6d4b\u665a\u671f NSCLC \u60a3\u8005\u7684\u7597\u6548\u4ee5\u53ca\u5176\u4ed6\u7624\u79cd\u60a3\u8005\u63a5\u53d7 ICI \u6cbb\u7597\u7684\u7597\u6548\uff0c\u5728\u4f4e TMB \u4eba\u7fa4\u4e2d\u7684\u8868\u73b0\u6700\u4e3a\u7a81\u51fa\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-021-01331-9<\/div>\n
\u00a0<\/div>\n
\u4ea7\u4e1a\u53d1\u5c55<\/div>\n
\u2756\u00a0\u5b89\u6377\u4f26\u5ba3\u5e03\u5c06\u4ee5\u6700\u9ad86.95\u4ebf\u7f8e\u5143\u6536\u8d2dResolution Bioscience<\/div>\n
\u5f53\u5730\u65f6\u95f42021\u5e743\u67082\u65e5\uff0c\u5b89\u6377\u4f26\u5ba3\u5e03\uff0c\u8ba1\u5212\u4ee55.5\u4ebf\u7f8e\u5143\u73b0\u91d1\u548c1.45\u4ebf\u7f8e\u5143\u91cc\u7a0b\u7891\u4ed8\u6b3e\u6536\u8d2d\u80bf\u7624\u7cbe\u51c6\u533b\u7597\u516c\u53f8Resolution Bioscience\u3002\u4ea4\u6613\u9884\u8ba1\u5c06\u4e8e\u56db\u6708\u5b8c\u6210\u3002Resolution Bioscience\u6709\u4e00\u4e2a\u57fa\u4e8eNGS\u7684\u65e0\u521b\u6db2\u4f53\u6d3b\u68c0\u68c0\u6d4b\u5e73\u53f0\uff0c\u53ef\u4ee5\u8bbe\u8ba1\u7528\u4e8e\u4e2d\u5fc3\u5316\u7684CLIA\u68c0\u6d4b\u670d\u52a1\u548c\u6279\u91cf\u8bd5\u5242\u76d2\u3002\u52302020\u5e74\uff0c\u8be5\u516c\u53f8\u7684\u6536\u5165\u4e3a3500\u4e07\u7f8e\u5143\uff0c\u5e76\u9884\u8ba1\u57282021\u5e74\u4ea7\u751f5000\u4e07\u81f35500\u4e07\u7f8e\u5143\u7684\u6536\u5165\u3002\u57fa\u56e0\u6167\u8ba4\u4e3a\uff0c\u56fd\u5185\u540c\u7c7b\u516c\u53f8\uff08\u4f8b\u5982\u9605\u5c14\u57fa\u56e0<\/a>\uff09\u5c06\u53d7\u5230\u8d44\u672c\u9752\u7750\uff0c\u5e76\u63a8\u52a8\u4e0a\u6e38\u6280\u672f\u6574\u5408\u521b\u65b0\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0Bio-Techne\u5c06\u4ee5\u6700\u9ad83.2\u4ebf\u7f8e\u5143\u6536\u8d2d\u5206\u5b50\u8bca\u65ad\u516c\u53f8Asuragen<\/div>\n
\u5f53\u5730\u65f6\u95f42021\u5e743\u67083\u65e5\uff0cBio-Techne\u6536\u5e02\u540e\u5ba3\u5e03\uff0c\u5b83\u5c06\u4ee52.15\u4ebf\u7f8e\u5143\u7684\u9996\u671f\u73b0\u91d1\u548c\u989d\u5916\u4e0d\u8d85\u8fc71.05\u4ebf\u7f8e\u5143\u91cc\u7a0b\u7891\u4ed8\u6b3e\u6536\u8d2d\u5206\u5b50\u8bca\u65ad\u516c\u53f8Asuragen\u3002Asuragen\u6210\u7acb\u4e8e2006\u5e74\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u3001\u5236\u9020\u548c\u5546\u4e1a\u5316\u57fa\u56e0\u643a\u5e26\u8005\u7b5b\u67e5\u548c\u80bf\u7624\u57fa\u56e0\u68c0\u6d4b\u8bd5\u5242\u76d2\uff0c\u5176\u4ea7\u54c1\u4f7f\u7528\u4e13\u6709\u7684\u5316\u5b66\u8bd5\u5242\u6765\u517c\u5bb9PCR\u3001qPCR\u3001\u6bdb\u7ec6\u7ba1\u7535\u6cf3\u548cNGS\u7b49\u591a\u79cd\u5e73\u53f0\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0Hologic\u4ee5\u7ea61.59\u4ebf\u7f8e\u5143\u6536\u8d2d\u4f20\u611f\u67d3\u68c0\u6d4b\u53ca\u8868\u89c2\u5206\u6790\u516c\u53f8Diagenode<\/div>\n
\u5f53\u5730\u65f6\u95f42021\u5e743\u67081\u65e5\uff0cHologic\u5ba3\u5e03\u5df2\u4ee5\u7ea61.59\u4ebf\u7f8e\u5143\u7684\u4ef7\u683c\u6536\u8d2d\u4e86Diagenode\u3002Diagenode\u662f\u4e00\u5bb6\u5206\u5b50\u8bca\u65ad\u548c\u8868\u89c2\u9057\u4f20\u5b66\u4ea7\u54c1\u7684\u5f00\u53d1\u5546\u548c\u5236\u9020\u5546\uff0c\u603b\u90e8\u4f4d\u4e8e\u6bd4\u5229\u65f6\uff0c\u4ea7\u54c1\u5305\u62ec30\u591a\u79cdCE\u8ba4\u8bc1\u7684qPCR\u68c0\u6d4b\uff08\u8986\u76d6\u6027\u4f20\u64ad\u611f\u67d3\uff0c\u547c\u5438\u7cfb\u7edf\u75be\u75c5\uff0c\u8111\u819c\u708e\u548c\u80a0\u80c3\u708e\u6709\u5173\u7684\u7ec6\u83cc\u3001\u5bc4\u751f\u866b\u548c\u75c5\u6bd2\u68c0\u6d4b\u7b49\uff09\uff0c\u8fd8\u62e5\u6709\u8868\u89c2\u9057\u4f20\u5b66\u5e73\u53f0\uff0c\u6db5\u76d6\u8bbe\u5907\u3001\u8bd5\u5242\u76d2\u3001\u8bd5\u5242\u8017\u6750\u3001\u6297\u4f53\u548cDNA\u548cRNA\u8f85\u52a9\u5206\u6790\u670d\u52a1\u7b49\u3002\u6b64\u524d\uff0cHologic\u4ee5\u7ea62.3\u4ebf\u7f8e\u5143\u6536\u8d2d\u80bf\u7624\u5206\u5b50\u68c0\u6d4b\u516c\u53f8Biotheranostics\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u8868\u578b\u548c\u53ca\u57fa\u56e0\u578b\u6574\u5408\u5e73\u53f0Genomics plc\u5b8c\u62103000\u4e07\u7f8e\u5143\u878d\u8d44\u3002\u00a0<\/div>\n
2021\u5e743\u67081\u65e5\uff0c\u81f4\u529b\u4e8e\u8868\u578b\u548c\u57fa\u56e0\u578b\u6570\u636e\u6574\u5408\u7684\u57fa\u56e0\u516c\u53f8Genomics plc\u5ba3\u5e03\u5b8c\u62103000\u4e07\u7f8e\u5143\u878d\u8d44\u3002Foresight Capital\u548cF-Prime Capital\u9886\u6295\uff0c\u4e0a\u4e00\u8f6e\u6295\u8d44\u8005Oxford Sciences Innovation\u548cLansdowne Partners\u8ddf\u6295\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u4ec5\u67096\u4eba\u7684\u57fa\u56e0\u6cbb\u7597\u516c\u53f8\u83b7\u5f97\u878d\u8d442000\u4e07\u7f8e\u5143<\/div>\n
2021\u5e743\u67081\u65e5\uff0c\u7f8e\u56fd\u57fa\u56e0\u6cbb\u7597\u516c\u53f8 SalioGen Therapeutics\u5ba3\u5e03\u5b8c\u6210\u4e86\u00a02000 \u4e07\u7f8e\u5143 A \u8f6e\u878d\u8d44\uff0c\u7531PBM Capital \u9886\u6295\u3002\u8fd9\u5bb6\u4ec5\u67096\u4eba\u7684\u521d\u521b\u516c\u53f8\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u89e3\u51b3\u75c5\u6bd2\u8f7d\u4f53\u5c40\u9650\u6027\uff0c\u5f00\u53d1\u4e86EDIT\u5e73\u53f0\uff0c\u57fa\u4e8e\u54fa\u4e73\u52a8\u7269\u884d\u751f\u7684\u9176 saliogase\uff0c\u5229\u7528 LNP \u9012\u9001\u4efb\u610f\u5927\u5c0f\u7684\u57fa\u56e0\u7247\u6bb5\u5230\u76ee\u6807\u7ec6\u80de\u3002PBM Capital \u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u533b\u7597\u5065\u5eb7\u548c\u751f\u547d\u79d1\u5b66\u9886\u57df\u7684\u6c11\u8425\u6295\u8d44\u516c\u53f8\u30022018 \u5e74\uff0c\u548c\u8bfa\u534e\u8fbe\u6210 87 \u4ebf\u7f8e\u5143\u7684\u5408\u4f5c\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u5b9e\u9a8c\u5ba4\u81ea\u52a8\u5316\u516c\u53f8Miroculus\u5b8c\u62104500\u4e07\u7f8e\u5143B\u8f6e\u878d\u8d44<\/div>\n
\u5f53\u5730\u65f6\u95f42021\u5e742\u670825\u65e5\uff0c\u5b9e\u9a8c\u5ba4\u81ea\u52a8\u5316\u516c\u53f8Miroculus\u5ba3\u5e03\u5df2\u5b8c\u6210\u4e86B\u8f6e\u878d\u8d44\u6269\u5c55\uff0c\u672c\u8f6e\u878d\u8d44\u603b\u989d\u8fbe\u52304500\u4e07\u7f8e\u5143\uff0c\u7531Cota Capital\u9886\u6295\uff0cSection 32\u8ddf\u6295\u3002\u672c\u8f6e\u878d\u8d44\u4e3b\u8981\u7528\u4e8e\u53bb\u5e74\u63d0\u51fa\u7684Miro Canvas\u6837\u54c1\u5236\u5907\u7cfb\u7edf\u7684\u5546\u4e1a\u5316\uff0c\u5373\u4f7f\u7528\u6570\u5b57\u5fae\u6d41\u63a7\u6280\u672f\u6765\u81ea\u52a8\u5316\u590d\u6742\u7684\u8fc7\u7a0b\uff0c\u4f8b\u5982\u5728\u57fa\u4e8e\u5361\u5f0f\u76d2\u7684\u7cfb\u7edf\u4e2d\u8fdb\u884cNGS\u6587\u5e93\u5236\u5907\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u897f\u6e56\u5927\u5b66\u6210\u679c\u8f6c\u5316\u7684\u897f\u6e56\u6b27\u7c73\u5b8c\u6210\u6570\u5343\u4e07\u5143\u79cd\u5b50\u8f6e\u878d\u8d44<\/div>\n
2021\u5e743\u67081\u65e5\uff0c\u897f\u6e56\u6b27\u7c73\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\u5b8c\u6210\u6570\u5343\u4e07\u5143\u79cd\u5b50\u8f6e\u878d\u8d44\uff0c\u7531\u8fb0\u5fb7\u8d44\u672c\u3001\u9ad8\u6995\u8d44\u672c\u5171\u540c\u9886\u6295\u3002\u897f\u6e56\u6b27\u7c73\u5c06\u86cb\u767d\u8d28\u7ec4\u5927\u6570\u636e\u4e0e\u4eba\u5de5\u667a\u80fd\u76f8\u7ed3\u5408\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u57fa\u4e8e\u86cb\u767d\u8d28\u7ec4\u548c\u5176\u4ed6\u5206\u5b50\u7ec4\u5b66\u7684\u8f85\u52a9\u4e34\u5e8a\u8bca\u65ad\u65b0\u65b9\u6cd5\uff0c\u52a9\u529b\u5b9e\u73b0\u80bf\u7624\u7b49\u4eba\u7c7b\u91cd\u5927\u75be\u75c5\u7684\u7cbe\u51c6\u8f85\u52a9\u8bca\u65ad\uff0c\u6838\u5fc3\u6280\u672f\u6765\u81ea\u4e8e\u897f\u6e56\u5927\u5b66\u90ed\u5929\u5357\u5b9e\u9a8c\u5ba4\uff0c\u897f\u6e56\u5927\u5b66\u6210\u679c\u8f6c\u5316\u529e\u516c\u5ba4\u5168\u7a0b\u52a9\u529b\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u4f70\u8fb0\u533b\u7597\u6253\u7834\u6211\u56fd\u4e34\u5e8a\u8d28\u8c31\u9886\u57df\u5355\u7b14\u878d\u8d44\u989d\u7eaa\u5f55<\/div>\n
2021\u5e743\u67083\u65e5\uff0c\u636e\u52a8\u8109\u7f51\u62a5\u9053\uff0c\u4e34\u5e8a\u8d28\u8c31\u68c0\u6d4b\u4f01\u4e1a\u6d59\u6c5f\u4f70\u8fb0\u533b\u7597\u79d1\u6280\u6709\u9650\u516c\u53f8\u5ba3\u5e03\u5b8c\u62103\u4ebf\u5143C\u8f6e\u878d\u8d44\uff0c\u7531CPE\u9886\u6295\uff0c\u534e\u76d6\u8d44\u672c\u3001\u590f\u5c14\u5df4\u6295\u8d44\u8ddf\u6295\uff0c\u534e\u5174\u8d44\u672c\u62c5\u4efb\u72ec\u5bb6\u8d22\u52a1\u987e\u95ee\u3002\u672c\u8f6e\u878d\u8d44\u521b\u9020\u4e86\u6211\u56fd\u4e34\u5e8a\u8d28\u8c31\u9886\u57df\u5355\u7b14\u878d\u8d44\u91d1\u989d\u7684\u6700\u9ad8\u7eaa\u5f55\u3002\u622a\u81f3\u76ee\u524d\uff0c\u4f70\u8fb0\u533b\u7597\u5df2\u7ecf\u5b8c\u6210\u4e864\u8f6e\u878d\u8d44\uff0c\u83b7\u5f97\u4e86\u5b81\u6ce2\u4e16\u5b9c\u3001\u666e\u534e\u8d44\u672c\u3001\u5408\u521b\u8d44\u672c\u3001\u8fbe\u6668\u521b\u6295\u3001\u5c71\u84dd\u8d44\u672c\u7b49\u6295\u8d44\u3002<\/div>\n
\u00a0<\/div>\n
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2021\u5e742\u670819\u65e5\uff0c\u6839\u636e\u516c\u5f00\u6d88\u606f\uff0c\u767e\u56fe\u751f\u79d1\uff08\u5317\u4eac\uff09\u667a\u80fd\u6280\u672f\u6709\u9650\u516c\u53f8\uff08\u7b80\u79f0\u201d\u767e\u56fe\u751f\u79d1\u201c\uff09\u53d1\u751f\u5de5\u5546\u53d8\u66f4\uff0c\u8be5\u516c\u53f8\u80a1\u4e1c\u4fe1\u606f\u663e\u793a\uff0c\u65b0\u589e\u674e\u5f66\u5b8f\u3001\u8fbe\u5b5c\u53bf\u767e\u745e\u7fd4\u521b\u4e1a\u6295\u8d44\u7ba1\u7406\u6709\u9650\u8d23\u4efb\u516c\u53f8\u4e3a\u80a1\u4e1c\uff0c\u5176\u4e2d\uff0c\u674e\u5f66\u5b8f\u6301\u6709\u767e\u56fe\u751f\u79d1\u80a1\u4efd1.0029%\uff0c\u901a\u8fc7\u8fbe\u5b5c\u53bf\u767e\u745e\u7fd4\u521b\u4e1a\u6295\u8d44\u7ba1\u7406\u6709\u9650\u8d23\u4efb\u516c\u53f8\u80a1\u6743\u7a7f\u900f\uff0c\u674e\u5f66\u5b8f\u5408\u8ba1\u6301\u6709\u767e\u56fe\u751f\u79d140.8029%\u7684\u80a1\u4efd\uff0c\u6210\u4e3a\u7b2c\u4e8c\u5927\u80a1\u4e1c\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0Biogen\u8ba1\u52122\u4ebf\u7f8e\u5143\u5efa\u7acb\u57fa\u56e0\u6cbb\u7597\u5de5\u5382<\/div>\n
2021\u5e743\u67084\u65e5\uff0cBiogen\u8ba1\u5212\u5728\u5317\u5361\u7f57\u6765\u7eb3\u5dde\u7684\u4e09\u89d2\u7814\u7a76\u56ed\uff08RTP\uff09\u5efa\u7acb\u65b0\u7684\u57fa\u56e0\u6cbb\u7597\u5236\u9020\u5de5\u5382\uff0c\u5360\u573017.5\u4e07\u5e73\u65b9\u82f1\u5c3a\uff0c\u5c06\u8017\u8d44\u7ea62\u4ebf\u7f8e\u5143\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u8d1d\u5eb7\u533b\u7597\u4e0eBioX\u4ea7\u7814\u9662\u8d3a\u6797\u9662\u58eb\u56e2\u961f\u7b7e\u7f72\u6210\u679c\u8f6c\u5316\u534f\u8bae<\/div>\n
2021\u5e743\u67086\u65e5\uff0c\u4e0a\u5e02\u516c\u53f8\u82cf\u5dde\u8d1d\u5eb7\u533b\u7597\u80a1\u4efd\u6709\u9650\u516c\u53f8\u4e0e\u82cf\u5ddeBioX\u751f\u547d\u667a\u80fd\u4ea7\u4e1a\u7814\u7a76\u9662\u8d3a\u6797\u9662\u58eb\u56e2\u961f\u7b7e\u7f72\u6210\u679c\u8f6c\u5316\u534f\u8bae\u3002\u53cc\u65b9\u5c31BioX\u4ea7\u7814\u9662\u57fa\u4e8e\u4eba\u5de5\u667a\u80fd\u7684\u9057\u4f20\u75c5\u7814\u7a76\u9879\u76ee\u6210\u679c\u8f6c\u5316\u8fbe\u6210\u5408\u4f5c\uff0c\u8d1d\u5eb7\u533b\u7597\u8463\u4e8b\u957f\u4e0eBioX\u4ea7\u7814\u9662\u8d3a\u6797\u9662\u58eb\u51fa\u5e2d\u4e86\u7b7e\u7ea6\u4eea\u5f0f\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>\u8d1d\u5eb7\u533b\u7597\u4e0eBioX\u4ea7\u7814\u9662\u8d3a\u6797\u9662\u58eb\u56e2\u961f\u7b7e\u7f72\u6210\u679c\u8f6c\u5316\u534f\u8bae<\/a><\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u4f1a\u8bae\u63a8\u8350<\/div>\n
3\u670811-13\u65e5\uff0c\u7b2c\u516d\u5c4a\u6613\u8d38\u751f\u7269\u4ea7\u4e1a\u5927\u4f1a\uff0c\u6c5f\u82cf\u7701\u82cf\u5dde\u5e02<\/div>\n
3\u670828-30\u65e5\uff0c\u7b2c\u5341\u516b\u5c4a\u4e2d\u56fd\u56fd\u9645\u68c0\u9a8c\u533b\u5b66\u66a8\u8f93\u8840\u4eea\u5668\u8bd5\u5242\u535a\u89c8\u4f1a\uff0c\u91cd\u5e86<\/div>\n
4\u670816-18\u65e5\uff0c\u7b2c\u4e94\u5c4a\u672a\u6765\u533b\u7597100\u5f3a\u5927\u4f1a\uff0c\u6c5f\u82cf\u7701\u82cf\u5dde\u5e02<\/div>\n
9\u67082-4\u65e5\uff0c\u4e2d\u534e\u533b\u5b66\u4f1a\u7b2c\u5341\u4e03\u6b21\u5168\u56fd\u68c0\u9a8c\u533b\u5b66\u5b66\u672f\u4f1a\u8bae\uff0c\u6e56\u5357\u7701\u957f\u6c99\u5e02<\/div>\n
9\u67083-5\u65e5\uff0c2021\u4e2d\u56fd\u80bf\u7624\u6807\u5fd7\u7269\u5b66\u672f\u5927\u4f1a\u66a8\u7b2c\u5341\u4e94\u5c4a\u80bf\u7624\u6807\u5fd7\u7269\u9752\u5e74\u79d1\u5b66\u5bb6\u8bba\u575b\uff0c\u8fbd\u5b81\u7701\u6c88\u9633\u5e02<\/div>\n
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