{"id":8927,"date":"2021-03-22T03:39:09","date_gmt":"2021-03-21T19:39:09","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&mid=100018715&idx=1&sn=2cfa75f207c2d31cd5722ee5bd381c18&chksm=6b7178ac5c06f1ba5f9de4774379b0eb3a9bfba36efca45038953ae3488724db5bcefcbc41be#rd"},"modified":"2026-04-01T15:46:13","modified_gmt":"2026-04-01T07:46:13","slug":"539857","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2021\/03\/22\/539857\/","title":{"rendered":"\u57fa\u56e0\u884c\u4e1a\u7b80\u62a5\uff08137\u671f\uff09"},"content":{"rendered":"
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\"RmFicvQBAkgC9dCnCVRM3QQyxPA2reWc4y8rSZKqo1lrBcIfCw0ZTJ35NUrPN0QpADYyH4MMFlRoxCZbn5envIw\"\/<\/figure><\/div>\n\n
\u56fe\uff1a\u80da\u80ce\u5728\u4eba\u9020\u5b50\u5bab\uff08\u5de6\uff09\u548c\u5b50\u5bab\uff08\u53f3\uff09\u4e2d\u53d1\u80b2\u5bf9\u6bd4<\/div>\n
\uff08\u6765\u6e90\/Nature)<\/div>\n
\u3010\u672c\u671f\u70ed\u70b9\u3011<\/div>\n
Illumina\u6362\u5e05<\/div>\n
\u300a\u56fd\u5bb6\u513f\u7ae5\u80bf\u7624\u76d1\u6d4b\u5e74\u62a52020\u300b\u53d1\u5e03<\/div>\n
\u534e\u5927\u667a\u9020\u3001\u8bfa\u552f\u8d5e\u79d1\u521b\u677f\u4e0a\u5e02\u7533\u8bf7\u8fdb\u5165\u5df2\u95ee\u8be2\u72b6\u6001<\/div>\n
\u9996\u6b21\u5728\u4eba\u9020\u5b50\u5bab\u4e2d\u5b9e\u73b0\u57f9\u517b\u54fa\u4e73\u52a8\u7269\u80da\u80ce<\/div>\n
DNA Script\u5c06\u53d1\u5e03\u53f0\u5f0f\u9176\u4fc3DNA\u5408\u6210\u4eea<\/div>\n
\u300a\u80bf\u7624\u57fa\u56e0\u68c0\u6d4b\u84dd\u76ae\u4e66\u300b\u542f\u52a8\uff0c\u9650\u91cf\u62db\u52df\u5408\u4f5c\u673a\u6784<\/div>\n
\u00a0<\/div>\n
\u5b8f\u89c2\u73af\u5883<\/div>\n
\u2756\u00a0\u300a\u56fd\u5bb6\u513f\u7ae5\u80bf\u7624\u76d1\u6d4b\u5e74\u62a52020\u300b\u53d1\u5e03<\/div>\n
2021\u5e743\u670820\u65e5\uff0c\u56fd\u5bb6\u513f\u7ae5\u80bf\u7624\u76d1\u6d4b\u4e2d\u5fc3\u53d1\u5e03\u9996\u671f\u300a\u56fd\u5bb6\u513f\u7ae5\u80bf\u7624\u76d1\u6d4b\u5e74\u62a52020\u300b\uff0c\u5e74\u62a5\u663e\u793a\uff0c\u5728\u6240\u76d1\u6d4b\u7684\u80bf\u7624\u60a3\u513f\u51fa\u9662\u4eba\u6b21\u4e2d\uff0c\u767d\u8840\u75c5\u4e3a\u60a3\u75c5\u6bd4\u4f8b\u6700\u591a\u7684\u75c5\u79cd\uff0c\u5360\u6bd457.21%\uff0c\u5176\u6b21\u662f\u4e0d\u660e\u53ca\u5176\u4ed6\u6076\u6027\u80bf\u7624\u3001\u6dcb\u5df4\u7624\u3001\u8111\u7624\u548c\u9aa8\u80bf\u7624\uff1b\u7537\u6027\u60a3\u513f\u5360\u5168\u90e8\u51fa\u9662\u4eba\u6b21\u6bd4\u4f8b\u4e3a59.52%\uff1b\u4f4f\u9662\u8d39\u7528\u7684\u533b\u7597\u4ed8\u8d39\u65b9\u5f0f\u4e2d\uff0c\u5168\u81ea\u8d39\u536033.56%\uff0c\u65b0\u519c\u5408\u536022.93%\uff0c\u57ce\u9547\u533b\u4fdd\u536019.38%\uff1b\u5168\u56fd\u80bf\u7624\u60a3\u513f\u672c\u7701\u5c31\u533b\u7684\u6bd4\u4f8b\u4e3a66.22%\u3002<\/div>\n
\u00a0<\/div>\n
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2021\u5e743\u670816\u65e5\uff0c\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u7f51\u7ad9\u516c\u5e03\u300a\u6d89\u53ca\u4eba\u7684\u751f\u547d\u79d1\u5b66\u548c\u533b\u5b66\u7814\u7a76\u4f26\u7406\u5ba1\u67e5\u529e\u6cd5\uff08\u5f81\u6c42\u610f\u89c1\u7a3f\uff09\u300b\u3002\u8fd9\u90e8\u5ba1\u67e5\u529e\u6cd5\u662f\u57282016\u5e74\u5b9e\u65bd\u7684\u300a\u6d89\u53ca\u4eba\u7684\u751f\u7269\u533b\u5b66\u7814\u7a76\u4f26\u7406\u5ba1\u67e5\u529e\u6cd5\u300b\u57fa\u7840\u4e0a\uff0c\u7ed3\u5408\u65b0\u7684\u5f62\u52bf\u548c\u8981\u6c42\u8d77\u8349\uff0c\u65e8\u5728\u4fdd\u62a4\u4eba\u7684\u751f\u547d\u548c\u5065\u5eb7\uff0c\u7ef4\u62a4\u4eba\u7684\u5c0a\u4e25\uff0c\u5c0a\u91cd\u548c\u4fdd\u62a4\u53d7\u8bd5\u8005\u7684\u5408\u6cd5\u6743\u76ca\uff0c\u4fc3\u8fdb\u751f\u547d\u79d1\u5b66\u548c\u533b\u5b66\u7814\u7a76\u5065\u5eb7\u53d1\u5c55\uff0c\u662f\u56fd\u5bb6\u751f\u7269\u5b89\u5168\u6cd5\u6cbb\u4f53\u7cfb\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u300a\u533b\u7597\u5668\u68b0\u76d1\u7763\u7ba1\u7406\u6761\u4f8b\u300b\u53d1\u5e03\uff0cLDT \u6a21\u5f0f\u5408\u6cd5\u5316<\/div>\n
2021\u5e743\u670818\u65e5\uff0c\u56fd\u52a1\u9662\u516c\u5e03\u4fee\u8ba2\u540e\u7684\u300a\u533b\u7597\u5668\u68b0\u76d1\u7763\u7ba1\u7406\u6761\u4f8b\u300b\uff0c\u5c06\u81ea2021\u5e746\u67081\u65e5\u8d77\u65bd\u884c\u3002\u6211\u56fd\u533b\u7597\u5668\u68b0\u884c\u4e1a\u76d1\u7ba1\u6cd5\u89c4\u6b63\u5f0f\u5b8c\u6210\u7b2c\u4e8c\u6b21\u5168\u9762\u4fee\u8ba2\u3002\u4e2d\u91d1\u516c\u53f8\u53d1\u5e03\u516c\u5f00\u516c\u5f00\u4e13\u9898\u7814\u62a5\u79f0\uff0c\u201c\u5176\u4e2d\u7b2c 53 \u6761 LDT \u6a21\u5f0f\u5408\u6cd5\u5316\u653f\u7b56\u5f15\u4eba\u77a9\u76ee\u201d\uff0c\u8ba4\u4e3a\u6761\u4f8b\u6240\u8ff0\u6a21\u5f0f\u4e3a LDT \u6a21\u5f0f\uff0cLDT \u6a21\u5f0f\u7684\u653e\u5f00\uff0c\u5bf9 ICL \u884c\u4e1a\u662f\u91cd\u5927\u5229\u597d\uff0c\u4e5f\u5229\u597d\u5206\u5b50\u8bca\u65ad\u884c\u4e1a\u4ea7\u54c1\u7684\u5b75\u5316\uff1b\u56fd\u5185\u77ed\u671f\u4ecd\u53d7\u9650\u672c\u5355\u4f4d\uff0c\u4f46\u5927\u6982\u7387\u53ef\u901a\u8fc7\u5408\u4f5c\u5171\u5efa\u53d7\u76ca\u3002<\/div>\n
\u00a0<\/div>\n
\u2756 \u6cb3\u5317\u7701\u5730\u65b9\u6807\u51c6\u300a\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\u4e34\u5e8a\u64cd\u4f5c\u6280\u672f\u89c4\u8303\u300b\u53d1\u5e03<\/div>\n
\u7ee72021\u5e742\u670810\u65e5\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u53d1\u5e03\u300a\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u4e34\u5e8a\u8bd5\u9a8c\u6280\u672f\u6307\u5bfc\u539f\u5219(\u8bd5\u884c)\u300b\u540e\uff0c\u8fd1\u65e5\uff0c\u6cb3\u5317\u7701\u5e02\u573a\u76d1\u7763\u7ba1\u7406\u5c40\u7ec4\u7ec7\u5236\u5b9a\u4e86\u300a\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\u4e34\u5e8a\u64cd\u4f5c\u6280\u672f\u89c4\u8303\u300b\uff0c\u89c4\u5b9a\u4e86\u76f8\u5173\u672f\u8bed\u4e0e\u5b9a\u4e49\u3001\u57fa\u672c\u8981\u6c42\u3001\u98ce\u9669\u9884\u6848\u3001\u5b9e\u65bd\u65b9\u6848\u7684\u5236\u5b9a\u3001\u5b9e\u65bd\u4e0e\u64cd\u4f5c\u3001\u6bd2\u526f\u53cd\u5e94\u7684\u5904\u7406\u3001\u60a3\u8005\u968f\u8bbf\u7b49\u5185\u5bb9\u3002\u6587\u4ef6\u9002\u7528\u4e8e\u5b9e\u65bd\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\u7684\u533b\u7597\u673a\u6784\u4e0e\u7ec6\u80de\u5236\u5907\u673a\u6784\uff0c\u4e8e2021\u5e742\u670821\u65e5\u5b9e\u65bd\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u5168\u56fd\u9996\u4e2a\u771f\u5b9e\u4e16\u754c\u6570\u636e\u7814\u7a76\u4e0e\u8bc4\u4ef7\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u843d\u6237\u6d77\u5357<\/div>\n
\u65e5\u524d\uff0c\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u5370\u53d1\u300a\u5173\u4e8e\u8ba4\u5b9a\u7b2c\u4e8c\u6279\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u7684\u901a\u77e5\u300b\uff0c\u6d77\u5357\u771f\u5b9e\u4e16\u754c\u6570\u636e\u7814\u7a76\u4e0e\u8bc4\u4ef7\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u83b7\u5f97\u56fd\u5bb6\u836f\u76d1\u5c40\u8ba4\u5b9a\uff0c\u5168\u56fd\u9996\u4e2a\u771f\u5b9e\u4e16\u754c\u6570\u636e\u7814\u7a76\u4e0e\u8bc4\u4ef7\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u843d\u6237\u6d77\u5357\u3002\u6b64\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u7531\u56db\u5ddd\u5927\u5b66\u534e\u897f\u533b\u9662\u3001\u535a\u9ccc\u8d85\u7ea7\u533b\u9662\u3001\u6d77\u5357\u7701\u535a\u9ccc\u5148\u884c\u533a\u836f\u54c1\u4e0d\u826f\u53cd\u5e94\u76d1\u6d4b\u4e2d\u5fc3\u4e09\u5bb6\u5355\u4f4d\u5171\u5efa\u3001\u5171\u7ba1\u3001\u5171\u4eab\u3002<\/div>\n
\u00a0<\/div>\n
\u2756 Cell\uff1a\u8fc8\u54112030\u5e74\uff0c\u7cbe\u51c6\u533b\u5b66\u7684\u4e03\u5927\u65b9\u5411<\/div>\n
\u8fd1\u65e5\uff0cCell\u671f\u520a\u53d1\u5e03\u6587\u7ae0\uff0c\u6307\u51fa\u8fc8\u54112030\u5e74\uff0c\u7cbe\u51c6\u533b\u5b66\u7684\u4e03\u5927\u65b9\u5411\uff1a<\/div>\n
1\uff09\u901a\u8fc7\u56fd\u9645\u5927\u578b\u7eb5\u5411\u961f\u5217\u5f00\u653e\u3001\u5171\u4eab\u548c\u5408\u4f5c\uff0c\u5145\u5206\u6316\u6398\u7fa4\u4f53\u6570\u636e\uff1b\u00a0<\/div>\n
2\uff09\u63d0\u9ad8\u751f\u7269\u533b\u5b66\u7814\u7a76\u4e2d\u4eba\u7fa4\u548c\u79d1\u7814\u8005\u7684\u591a\u6837\u6027\u548c\u5305\u5bb9\u6027\uff1b\u00a0<\/div>\n
3\uff09\u7528\u5927\u6570\u636e\u548c\u4eba\u5de5\u667a\u80fd\uff0c\u5206\u6790\u4e34\u5e8a\u3001\u5206\u5b50\u548c\u53ef\u7a7f\u6234\u8bbe\u5907\u7b49\u65b9\u9762\u7684\u6570\u636e\uff1b\u00a0<\/div>\n
4\uff09\u4e34\u5e8a\u57fa\u56e0\u7ec4\u5b66\u8f85\u52a9\u5e38\u89c1\u75c5\u548c\u7f55\u89c1\u75c5\u7684\u9884\u9632\u3001\u8bca\u65ad\u548c\u6cbb\u7597\u6210\u5e38\u6001\u5316\uff1b<\/div>\n
5\uff09\u7535\u5b50\u5065\u5eb7\u6863\u6848\u5c06\u6210\u4e3a\u8868\u578b\u7ec4\u548c\u57fa\u56e0\u7ec4\u7814\u7a76\u7684\u91cd\u8981\u8d44\u6e90\uff1b<\/div>\n
6\uff09\u5e94\u7528\u66f4\u52a0\u591a\u6837\u5316\u3001\u66f4\u9ad8\u5206\u8fa8\u7387\u7684\u8868\u578b\u7ec4\u5b66\u548c\u73af\u5883\u66b4\u9732\u6570\u636e\uff1b\u00a0<\/div>\n
7\uff09\u901a\u8fc7\u5efa\u7acb\u4fe1\u4efb\u3001\u9690\u79c1\u4fdd\u62a4\u548c\u4ef7\u503c\u56de\u9988\u673a\u5236\uff0c\u4fc3\u8fdb\u6c11\u4f17\u5e7f\u6cdb\u53c2\u4e0e<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(21)00058-1<\/div>\n
\u00a0<\/div>\n
\u524d\u6cbf\u6280\u672f<\/div>\n
\u2756\u00a0Nature\uff1a\u5168\u7403\u9996\u4f8b\u4eba\u7c7b\u80da\u80ce\u6837\u7ed3\u6784\u7814\u7a76\u6210\u679c\u516c\u5e03<\/div>\n\n
\n
\"RmFicvQBAkgC9dCnCVRM3QQyxPA2reWc44ibns7xAIq369BdicuNrkhJuY3fAyzpSxWAbh4cktRic0nf9mibHmE3U3w\"\/<\/figure><\/div>\n\n
\u56fe\uff1a\u4eba\u9020\u4eba\u7c7b\u80da\u80ce\u6837\u7ed3\u6784\uff08\u6765\u6e90\/Nature)<\/div>\n
2021\u5e743\u670817\u65e5\uff0c\u636eBioArt\u62a5\u9053\uff0c\u7f8e\u56fd\u5fb7\u514b\u8428\u65af\u897f\u5357\u533b\u5b66\u4e2d\u5fc3\u5206\u5b50\u751f\u7269\u5b66\u7684\u5434\u519b\u8bfe\u9898\u7ec4\u5728Nature\u671f\u520a\u4e0a\u53d1\u8868\u7814\u7a76\u6210\u679c\uff0c\u6210\u529f\u5730\u7528\u4eba\u591a\u80fd\u6027\u5e72\u7ec6\u80de\uff08Pluripotent stem cells\uff09\u5206\u5316\u8bf1\u5bfc\u51fa\u4eba\u7c7b\u65e9\u671f\u80da\u80ce\u6837\u7ed3\u6784\uff08\u547d\u540d\u4e3aBlastoid\uff09\u3002\u8be5\u7ed3\u6784\u4e0e\u4eba\u56ca\u80da\u671f\u80da\u80ce\uff08Blastocyst\uff09\u5177\u6709\u7c7b\u4f3c\u7684\u7ed3\u6784\uff0c\u6b63\u786e\u5730\u8868\u8fbe\u76f8\u5e94\u7684\u57fa\u56e0\u4e0e\u86cb\u767d\uff0c\u5e76\u4e14\u53ef\u4ee5\u5728\u4f53\u5916\u53d1\u80b22-4\u5929\uff0c\u5f62\u6210\u7c7b\u7f8a\u819c\u56ca\u7b49\u7ed3\u6784\u3002\u540c\u4e00\u65f6\u95f4 \uff0c\u6765\u81ea\u6fb3\u5927\u5229\u4e9a\u83ab\u7eb3\u4ec0\u5927\u5b66\uff08Monash University\uff09\u7684Jose Polo\u56e2\u961f\u5728Nature\u671f\u520a\u53d1\u8868\u4e86\u901a\u8fc7\u4f53\u7ec6\u80de\u91cd\u7f16\u7a0b\u7684\u6280\u672f\u6784\u5efa\u4e86\u5168\u7403\u9996\u4f8b\u4eba\u7c7b\u80da\u80ce\u6837\u7ed3\u6784\u7684\u6210\u679c\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/www.nature.com\/articles\/s41586-021-03356-y<\/div>\n
https:\/\/www.nature.com\/articles\/s41586-021-03372-y<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0Science\uff1a\u57fa\u4e8e\u53e4\u4eba\u7c7bNOVA1\u57fa\u56e0\u57f9\u517b\u51fa\u5927\u8111\u7c7b\u5668\u5b98<\/div>\n
2021\u5e742\u670811\u65e5\uff0c\u52a0\u5dde\u5927\u5b66\u5723\u8fed\u6208\u5206\u6821\u7684\u795e\u7ecf\u79d1\u5b66\u5bb6Alysson Muotri\u56e2\u961f\uff0c\u4f7f\u7528\u57fa\u56e0\u7ec4\u7f16\u8f91\u6280\u672fCRISPR\u2013Cas9\u5c06\u53e4\u4eba\u7c7b\u7684NOVA1\u57fa\u56e0\u5bfc\u5165\u4eba\u591a\u80fd\u5e72\u7ec6\u80de\u5185\uff08\u591a\u80fd\u5e72\u7ec6\u80de\u80fd\u591f\u53d1\u80b2\u6210\u6240\u6709\u7c7b\u578b\u7684\u7ec6\u80de\uff09\uff0c\u7136\u540e\u4ed6\u4eec\u5c06\u8fd9\u4e9b\u7ec6\u80de\u57f9\u517b\u6210\u76f4\u5f84\u6700\u59275\u6beb\u7c73\u7684\u5927\u8111\u7c7b\u5668\u5b98\u3002Nature\u5bf9\u6b64\u53d1\u8868\u4e86\u76f8\u5173\u8bc4\u8bba\u6587\u7ae0\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/science.sciencemag.org\/content\/371\/6530\/eaax2537<\/div>\n
https:\/\/www.nature.com\/articles\/d41586-021-00388-2?utm_source=Wechat&utm_medium=social&utm_campaign=d41586-021-00388-2<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0Nature\uff1a\u9996\u6b21\u5728\u4eba\u9020\u5b50\u5bab\u4e2d\u5b9e\u73b0\u57f9\u517b\u54fa\u4e73\u52a8\u7269\u80da\u80ce<\/div>\n
2021\u5e743\u670817\u65e5\uff0c\u636e\u751f\u7269\u4e16\u754c\u62a5\u9053\uff0c\u4ee5\u8272\u5217\u9b4f\u8328\u66fc\u79d1\u5b66\u7814\u7a76\u6240\u7684 Jacob H. Hanna\u7b49\u4eba\u5728 Nature \u671f\u520a\u5728\u7ebf\u53d1\u8868\u7814\u7a76\u8bba\u6587\u3002\u8be5\u56e2\u961f\u521b\u5efa\u4e86\u4e00\u4e2a\u4eba\u9020\u673a\u5668\u5b50\u5bab\uff0c\u5e76\u9996\u6b21\u4f7f\u7528\u4eba\u9020\u5b50\u5bab\u57f9\u517b\u4e86\u5c0f\u9f20\u80da\u80ce6\u5929\u65f6\u95f4\uff08\u8fbe\u5230\u5c0f\u9f20\u6574\u4e2a\u598a\u5a20\u671f\u7684\u4e09\u5206\u4e4b\u4e00\uff09\uff0c\u4e14\u80da\u80ce\u5728\u4eba\u9020\u5b50\u5bab\u57f9\u80b2\u8fc7\u7a0b\u4e2d\u53d1\u80b2\u6b63\u5e38\u3002\u8fd9\u9879\u7814\u7a76\u5c06\u4e3a\u79d1\u7814\u4eba\u5458\u63d0\u4f9b\u524d\u6240\u672a\u6709\u7684\u5de5\u5177\uff0c\u5e2e\u52a9\u4e86\u89e3\u57fa\u56e0\u7f16\u7801\u7684\u53d1\u80b2\u7a0b\u5e8f\uff0c\u63d0\u4f9b\u6709\u5173\u51fa\u751f\u7f3a\u9677\u548c\u53d1\u80b2\u7f3a\u9677\u4ee5\u53ca\u4e0e\u80da\u80ce\u690d\u5165\u6709\u5173\u7f3a\u9677\u7684\u8be6\u7ec6\u89c1\u89e3\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/www.nature.com\/articles\/s41586-021-03416-3<\/div>\n
\u00a0<\/div>\n
\u4ea7\u54c1\u5e94\u7528<\/div>\n
\u2756\u00a0DNA Script\u5c06\u53d1\u5e03\u53f0\u5f0f\u9176\u4fc3DNA\u5408\u6210\u4eea<\/div>\n
\u4eca\u65e5\uff0cDNA Script\u5ba3\u5e03\uff0c\u7ecf\u8fc7\u4e0e\u5408\u4f5c\u4f19\u4f34\u7ea6\u4e00\u5e74\u7684\u6d4b\u8bd5\uff0cDNA Script\u51c6\u5907\u5728\u4eca\u5e74\u665a\u4e9b\u65f6\u5019\u63a8\u51fa\u53f0\u5f0f\u9176\u4fc3DNA\u5408\u6210\uff08EDS\uff09\u4eea\u5668Syntax\uff0c\u76ee\u524d\u9488\u5bf9\u7684\u662f\u5bf9\u5be1\u6838\u82f7\u9178\u6709\u5f88\u9ad8\u9700\u6c42\u7684\u5206\u5b50\u751f\u7269\u5b66\u548c\u57fa\u56e0\u7ec4\u5b66\u7814\u7a76\u5b9e\u9a8c\u5ba4 \u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u8fea\u8c31\u8bca\u65ad\u5c06\u6b63\u5f0f\u53d1\u5e03DP-TOF\u98de\u884c\u65f6\u95f4\u8d28\u8c31\u68c0\u6d4b\u7cfb\u7edf<\/div>\n
\u6839\u636e\u8fea\u8c31\u8bca\u65ad\u5b98\u65b9\u6d88\u606f\uff0c\u8fea\u8c31\u8bca\u65ad\u5c06\u4e8e2021\u5e743\u670826\u65e5\u6b63\u5f0f\u53d1\u5e03DP-TOF\u98de\u884c\u65f6\u95f4\u8d28\u8c31\u68c0\u6d4b\u7cfb\u7edf\u3002\u8be5\u7cfb\u7edf\u662f\u8fea\u8c31\u8bca\u65ad\u81ea\u4e3b\u7814\u53d1\uff0c\u5e76\u4e8e2020\u5e7412\u670828\u65e5\u83b7\u5f97\u6d59\u6c5f\u7701\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u533b\u7597\u5668\u68b0\u6ce8\u518c\u8bc1\uff08\u6ce8\u518c\u8bc1\u7f16\u53f7\uff1a\u6d59\u68b0\u6ce8\u51c620202220910\uff09\uff0c\u8fd9\u662f\u56fd\u5185\u9996\u6b3e\u83b7\u6279\u7684\u901a\u7528\u578b\u98de\u884c\u65f6\u95f4\u6838\u9178\u8d28\u8c31\u68c0\u6d4b\u7cfb\u7edf\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u57fa\u77f3\u836f\u4e1a\u7684\u4e24\u6b3e\u57fa\u56e0\u9776\u5411\u836f\u8fdb\u5165\u201c\u5728\u5ba1\u6279\u201d\u72b6\u6001<\/div>\n
3\u670819\u65e5\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u76d1\u5c40\uff08NMPA\uff09\u5b98\u7f51\u663e\u793a\uff0c\u57fa\u77f3\u836f\u4e1a\u7533\u62a5\u7684\u963f\u4f10\u66ff\u5c3c (avapritinib)\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\uff08NDA\uff09\u5ba1\u8bc4\u5ba1\u6279\u72b6\u6001\u5df2\u66f4\u65b0\u4e3a\u201c\u5728\u5ba1\u6279\u201d\u3002\u5982\u679c\u83b7\u6279\uff0c\u5b83\u5c06\u6709\u671b\u6210\u4e3a\u4e2d\u56fd\u9996\u4e2aPDGFRA\u5916\u663e\u5b5018\u7a81\u53d8\u7684\u80c3\u80a0\u9053\u95f4\u8d28\u7624\u6cbb\u7597\u836f\u7269\u3002\u6b64\u5916\uff0c\u57fa\u77f3\u836f\u4e1a\u7533\u62a5\u7684\u53e6\u4e00\u6b3e\u57fa\u56e0\u9776\u5411\u6297\u764c\u836f\u666e\u62c9\u66ff\u5c3c(pralsetinib)\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u4e5f\u4e8e\u8fd1\u65e5\u8fdb\u5165\u201c\u5728\u5ba1\u6279\u201d\u72b6\u6001\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0NEJM\uff1a\u4e34\u5e8a\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u53ef\u4f5c\u4e3a\u9ad3\u7cfb\u80bf\u7624\u7ec6\u80de\u9057\u4f20\u5b66\u5206\u6790\u66ff\u4ee3\u65b9\u6cd5<\/div>\n\n
\n
\"RmFicvQBAkgC9dCnCVRM3QQyxPA2reWc4kQ1hOQsWoggcPoezhNC9Rzkxs5ViapJVdQPkC2dGVcHkREvQicoqFPNg\"\/<\/figure><\/div>\n\n
2021\u5e743\u670811\u65e5\uff0c\u636e\u6d4b\u5e8f\u4e2d\u56fd\u62a5\u9053\uff0c\u534e\u76db\u987f\u5927\u5b66\u533b\u5b66\u9662\u7b49\u5355\u4f4d\u7684\u7814\u7a76\u5458\u5728NEJM\uff08\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u300b\uff09\u4e0a\u53d1\u8868\u7814\u7a76\u6027\u6587\u7ae0\uff0c\u62a5\u9053\u4e86\u4e00\u79cd\u5bf9AML\u6216MDS\u60a3\u8005\u8fdb\u884c\u57fa\u56e0\u7ec4\u7279\u5f81\u5206\u6790\u7684\u4f18\u5316\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u65b9\u6cd5\uff0c\u5e76\u5c06\u5176\u5e94\u7528\u4e8e\u4e34\u5e8a\u6837\u672c\u3002\u7ed3\u679c\u8868\u660e\uff0c\u4e0e\u5e38\u89c4\u7ec6\u80de\u9057\u4f20\u5b66\u5206\u6790\u76f8\u6bd4\uff0c\u8be5\u65b9\u6cd5\u7684\u8bca\u65ad\u654f\u611f\u6027\u76f8\u4f3c\u6216\u66f4\u4f73\uff0c\u5e76\u4e14\u6839\u636e\u6807\u51c6\u98ce\u9669\u7c7b\u522b\u5c06\u60a3\u8005\u8fdb\u884c\u98ce\u9669\u5206\u5c42\u7684\u6548\u7387\u66f4\u9ad8\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2024534<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u7ee7\u65e5\u672c\u540e\uff0c\u8bfa\u534eCAR-T\u7ec6\u80de\u5728\u65b0\u52a0\u5761\u83b7\u6279\u4e0a\u5e02<\/div>\n
2021\u5e743\u67089\u65e5\uff0c\u8bfa\u534e\uff08Novartis\uff09\u5ba3\u5e03\uff0c\u6839\u636e\u65b0\u7684\u7ec6\u80de\u3001\u7ec4\u7ec7\u548c\u57fa\u56e0\u6cbb\u7597\u4ea7\u54c1\uff08CTGTP\uff09\u76d1\u7ba1\u6846\u67b6\uff0c\u65b0\u52a0\u5761\u5065\u5eb7\u79d1\u5b66\u7ba1\u7406\u5c40\uff08HSA\uff09\u5df2\u6279\u51c6Kymriah\uff08tisagenlecleucel\uff09\uff0c\u7528\u4e8e\u6cbb\u75972-25\u5c81\u60a3\u6709\u96be\u6cbb\u6027\u3001\u79fb\u690d\u540e\u590d\u53d1\u3001\u7b2c\u4e8c\u6b21\u6216\u591a\u6b21\u590d\u53d1\u7684B\u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08ALL\uff09\u513f\u7ae5\u548c\u5e74\u8f7b\u6210\u4eba\u60a3\u8005\uff0c\u6216\u80052\u7ebf\u6216\u4ee5\u4e0a\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027\uff08r\/r\uff09\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff08DLBCL\uff09\u6210\u4eba\u60a3\u8005\u3002\u56e0\u6b64\uff0cKymriah\u6210\u4e3a\u65b0\u52a0\u5761\u9996\u4e2a\u5546\u4e1a\u5316\u7684CAR-T\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\uff0c\u65b0\u52a0\u5761\u603b\u533b\u9662\uff08SGH\uff09\u662f\u4e1c\u5357\u4e9a\u9996\u5bb6\u6295\u5165\u8fd0\u8425\u7684Kymriah\u6cbb\u7597\u4e2d\u5fc3\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0CDE\u516c\u793a\u00a05 \u6b3e\u65b0\u836f\u7eb3\u5165\u7a81\u7834\u6027\u7597\u6cd5\u7a0b\u5e8f<\/div>\n
2021\u5e743\u670816\u65e5\uff0c\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09 \u5b98\u7f51\u516c\u793a\uff0c\u62df\u5c06 5 \u6b3e\u65b0\u836f\u7eb3\u5165\u7a81\u7834\u6027\u7597\u6cd5\u7a0b\u5e8f\u3002\u5305\u62ec\uff1a\u00a0<\/div>\n
1\uff09\u541b\u5b9e\u751f\u7269\u7684 PD-1 \u7279\u745e\u666e\u5229\u5355\u6297\u7528\u4e8e\u9ecf\u819c\u9ed1\u8272\u7d20\u7624\u4e00\u7ebf\u6cbb\u7597\uff1b\u00a0<\/div>\n
2\uff09\u8bfa\u548c\u8bfa\u5fb7\u7684\u957f\u6548 GLP-1 \u6291\u5236\u5242\u53f8\u7f8e\u9c81\u80bd\uff08Semaglutide\uff0c\u7d22\u9a6c\u9c81\u80bd\uff09\u7528\u4e8e NASH \u6cbb\u7597\uff1b\u00a0<\/div>\n
3\uff09\u5fae\u82af\u751f\u7269 1 \u7c7b\u65b0\u836f\u897f\u5965\u7f57\u5c3c\u7528\u4e8e\u5375\u5de2\u764c\u6cbb\u7597\uff1b\u00a0<\/div>\n
4\uff09\u8a89\u8861\u751f\u7269\/\u836f\u660e\u751f\u7269 PD-1 \u5355\u6297\u8d5b\u5e15\u5229\u5355\u6297\uff08GLS-010\uff09\u7528\u4e8e\u5bab\u9888\u764c\u6cbb\u7597\uff1b\u00a0<\/div>\n
5\uff09\u4e0a\u6d77\u777f\u661f\u7684\u7f9f\u5c3c\u916e\u80f6\u56ca\u7528\u4e8e\u6162\u6027\u4e59\u809d\u809d\u7ea4\u7ef4\u5316\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u6d59\u5927\u7e41\u661f\u516c\u76ca\u57fa\u91d1\u6295\u51651\u4ebf\u7f8e\u91d1\u7528\u4e8e\u8ba1\u7b97\u751f\u7269\u7b49\u9886\u57df<\/div>\n
2021\u5e743\u670817\u65e5\uff0c\u6d59\u6c5f\u5927\u5b66\u6559\u80b2\u57fa\u91d1\u4f1a\u548c\u7e41\u661f\u516c\u76ca\u57fa\u91d1\u7b7e\u7f72\u6350\u8d60\u534f\u8bae\uff0c\u8bbe\u7acb\u201c\u6d59\u6c5f\u5927\u5b66\u4e0a\u6d77\u9ad8\u7b49\u7814\u7a76\u9662\u7e41\u661f\u79d1\u5b66\u57fa\u91d1\u201d\uff0c\u4f5c\u4e3a\u7b2c\u4e00\u671f\u8d44\u52a9\uff0c\u7e41\u661f\u516c\u76ca\u57fa\u91d1\u5c06\u5728\u672a\u67653-5\u5e74\u5411\u6d59\u6c5f\u5927\u5b66\u6559\u80b2\u57fa\u91d1\u4f1a\u6350\u52a91\u4ebf\u7f8e\u5143\uff0c\u7528\u4e8e\u201c\u8ba1\u7b97+\u751f\u7269\u533b\u7597\u201d\u201c\u8ba1\u7b97+\u519c\u4e1a\u98df\u54c1\u201d\u548c\u201c\u5148\u8fdb\u8ba1\u7b97\u201d\u4e09\u4e2a\u521b\u65b0\u5b9e\u9a8c\u5ba4\u7684\u79d1\u5b66\u7814\u7a76\u9879\u76ee\u3002\u9996\u6279\u9879\u76ee\u5305\u62ec\u201c\u9762\u5411\u8d85\u5927\u89c4\u6a21\u65f6\u5e8f\u5173\u8054\u6570\u636e\u7684\u5b9e\u65f6\u56fe\u63a8\u7406\u673a\u7814\u7a76\u201d\u3001\u201c\u91cd\u5927\u8111\u8ba4\u77e5\u969c\u788d\u7684\u95ed\u73af\u8c03\u63a7\u201d\u3001\u201c\u80bf\u7624\u514d\u75ab\u65b0\u6297\u539f\u8bbe\u8ba1\u4e0e\u5e94\u7528\u201d\u548c\u201c\u7ec6\u80de\u57f9\u517b\u4eba\u9020\u9c7c\u8089\u7814\u7a76\u201d\u7b49\u3002<\/div>\n
\u00a0<\/div>\n
\u4ea7\u4e1a\u53d1\u5c55<\/div>\n
\u2756\u00a0Illumina\u6362\u5e05<\/div>\n
2021\u5e743\u670819\u65e5\uff0cIllumina\u5ba3\u5e03Jay Flatley\u5c06\u4ece\u516c\u53f8\u8463\u4e8b\u4f1a\u8f9e\u804c\uff0cJohn Thompson\u63a5\u66ff\u4ed6\u62c5\u4efb\u8463\u4e8b\u4f1a\u4e3b\u5e2d\uff0c\u81ea5\u670826\u65e5\u751f\u6548\u3002Flatley\u57281999\u5e74\u81f32016\u5e74\u671f\u95f4\u9886\u5bfcIllumina\u62c5\u4efbCEO\uff0c\u5e76\u57282016\u5e74\u81f32019\u5e74\u62c5\u4efb\u8463\u4e8b\u4f1a\u6267\u884c\u4e3b\u5e2d\uff0c\u5e26\u5934\u9886\u5bfc\u4e86Illumina\u5bf9Solexa\u7684\u6536\u8d2d\u3002Thompson\u62e5\u6709MIT\u65af\u9686\u7ba1\u7406\u5b66\u9662\u7684\u7ba1\u7406\u79d1\u5b66\u7855\u58eb\u5b66\u4f4d\uff0c\u81ea2017\u5e74\u4ee5\u6765\u4e00\u76f4\u62c5\u4efbIllumina\u8463\u4e8b\u4f1a\u6210\u5458\u3002\u4ed6\u662fLightspeed Ventures\u7684\u5408\u4f19\u4eba\uff0c\u66fe\u62c5\u4efbVirtual Instruments\u548cSymantec\u7684CEO\uff0c\u5e76\u5728IBM\u768428\u5e74\u804c\u4e1a\u751f\u6daf\u4e2d\u62c5\u4efb\u8fc7\u9500\u552e\uff0c\u5e02\u573a\u8425\u9500\u548c\u8f6f\u4ef6\u5f00\u53d1\u65b9\u9762\u7684\u9ad8\u7ea7\u804c\u52a1\u3002\u6c64\u666e\u68ee\u8fd8\u662f\u5fae\u8f6f\u8463\u4e8b\u4f1a\u4e3b\u5e2d\uff0c\u662fRubrik\u548cSeismic Software\u673a\u6784\u7684\u8463\u4e8b\u4f1a\u6210\u5458\u3002<\/div>\n
\u00a0<\/div>\n
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2021\u5e743\u670820\u65e5\uff0c\u6839\u636e\u4e0a\u6d77\u8bc1\u5238\u4ea4\u6613\u6240\u516c\u793a\uff0c\u5357\u4eac\u8bfa\u552f\u8d5e\u751f\u7269\u79d1\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8\u3001\u6df1\u5733\u534e\u5927\u667a\u9020\u79d1\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8\u5206\u522b\u57283\u670819\u65e5\u30013\u670820\u65e5\u8fdb\u5165\u201c\u5df2\u95ee\u8be2\u201d\u72b6\u6001\u3002\u5176\u4e2d\uff0c\u6839\u636e\u95ee\u8be2\u4e0e\u56de\u590d\u610f\u89c1\uff0c\u622a\u81f3 2020 \u5e74 9 \u6708\u672b\uff0c\u534e\u5927\u667a\u9020\u7d2f\u8ba1\u672a\u5f25\u8865\u4e8f\u635f\u4e3a 225,119.66 \u4e07\u5143\uff08\u6574\u4f53\u7814\u53d1\u652f\u51fa\u53ca\u5176\u4ed6\u5404\u7c7b\u8d39\u7528\u652f\u51fa\u91d1\u989d\u8f83\u9ad8\uff09\uff1b\u6839\u636e\u95ee\u8be2\u4e0e\u56de\u590d\u610f\u89c1\uff0c\u8bfa\u552f\u8d5e\u7684\u7684POCT \u8bca\u65ad\u8bd5\u5242\u6bdb\u5229\u7387\u4ece2017\u5e74\u521a\u83b7\u8bc1\u65f6\u7684-208.20%\u4e0a\u5347\u52302020\u5e74\u768491.06%\uff08\u4e3b\u8425\u4e1a\u52a1\u6bdb\u5229\u738795.83%\uff09\u3002<\/div>\n
\u00a0<\/div>\n
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\"RmFicvQBAkgAPaJMHaiaWEuVcGia3yvXhZOoaj9cMia4jxGMnG2RaNK3UBO38qGiaQupNEENUUV96jQ3b1qenzLApQw\"\/<\/figure><\/div>\n\n
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2021\u5e743\u670815\u65e5\uff0c\u636e\u534e\u5c14\u8857\u65e5\u62a5\u62a5\u9053\uff0c\u7f57\u6c0f(Roche)\u5c06\u4ee518\u4ebf\u7f8e\u5143\u6536\u8d2d\u7f8e\u56fd\u5206\u5b50\u75c5\u7406\u68c0\u9a8c\u751f\u4ea7\u5546GenMark Diagnostics\uff0c\u6839\u636e\u6536\u8d2d\u534f\u8bae\uff0c\u7f57\u6c0f\u5c06\u4ee5\u6bcf\u80a124.05\u7f8e\u5143\u5168\u73b0\u91d1\u6536\u8d2dGenMark\uff0c\u8f83GenMark 2\u670810\u65e5\u7684\u6536\u5e02\u4ef7\u6ea2\u4ef743%\u3002\u8be5\u4ea4\u6613\u5df2\u83b7\u5f97\u7f57\u6c0f\uff08Roche\uff09\u548cGenMark\u8463\u4e8b\u4f1a\u7684\u6279\u51c6\uff0c\u9884\u8ba1\u5c06\u4e8e\u4eca\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u5b8c\u6210\u3002<\/div>\n
GenMark Diagnostics, Inc\u516c\u53f8\u81f4\u529b\u4e8e\u57fa\u4e8eeSensor\u7535\u5316\u5b66\u68c0\u6d4b\u6280\u672f\uff0c\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u8f85\u52a9\u8bca\u65ad\u590d\u6742\u533b\u5b66\u72b6\u51b5\u7684\u590d\u5408\u5206\u5b50\u68c0\u6d4b\u3002\u5176\u4e2d\u5305\u62ecFDA\u6279\u51c6\u76844\u9879\u5728XT-8\u4eea\u5668\u4e0a\u8fd0\u884c\u7684\u8bca\u65ad\u6d4b\u8bd5\uff0c\u5305\u62ec\u547c\u5438\u75c5\u6bd2\u68c0\u6d4b\u3001\u56ca\u6027\u7ea4\u7ef4\u5316\u57fa\u56e0\u5206\u578b\u3001\u534e\u6cd5\u6797\u654f\u611f\u6027\u6d4b\u8bd5\u548c\u8840\u6813\u5f62\u6210\u98ce\u9669\u68c0\u6d4b\u3002\u6b64\u5916\uff0c\u5b83\u8fd8\u4e19\u578b\u809d\u708e\u57fa\u56e0\u5206\u578b\u4ee5\u53ca2C19\u57fa\u56e0\u5206\u578b\u68c0\u6d4b\u7b49\u3002<\/div>\n
\u00a0<\/div>\n
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\u8fd1\u65e5\uff0c\u5408\u6210\u751f\u7269\u5b66\u6280\u672f\u5f00\u53d1\u5546\u6069\u548c\u751f\u7269\u5b8c\u6210\u6218\u7565\u878d\u8d44\uff0c\u6295\u8d44\u65b9\u4e3aBASF\u5df4\u65af\u592b\u3002\u53bb\u5e74\uff0c\u6069\u548c\u751f\u7269\u5b8c\u62101500\u4e07\u7f8e\u5143A\u8f6e\u878d\u8d44\uff0c\u7531\u7ecf\u7eac\u4e2d\u56fd\u9886\u6295,\u590f\u5c14\u5df4\u6295\u8d44\u3001BV\u767e\u5ea6\u98ce\u6295\u7b49\u673a\u6784\u8ddf\u6295\u3002Bota Bio \u662f\u56fd\u5185\u5934\u90e8\u5408\u6210\u751f\u7269\u6280\u672f\u5e73\u53f0\u521d\u521b\u516c\u53f8\uff0c\u603b\u90e8\u4f4d\u4e8e\u6d59\u6c5f\u676d\u5dde\uff0cCEO\u662f\u54c8\u4f5b – \u9ebb\u7701\u7406\u5de5\u5b66\u9662\u533b\u5b66\u5de5\u7a0b\u548c\u751f\u7269\u7269\u7406\u535a\u58eb Cheryl Cui\u3002<\/div>\n
\u00a0<\/div>\n
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\u00a0<\/div>\n
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2021\u5e743\u670818\u65e5\uff0c\u636e\u8d1d\u745e\u57fa\u56e0\u5b98\u65b9\u62a5\u9053<\/a>\uff0c\u4e3a\u4e86\u7a81\u7834\u5730\u4e2d\u6d77\u8d2b\u8840\u4f20\u7edf\u7814\u7a76\u7684\u5c40\u9650\uff0c\u63a2\u7d22\u5730\u8d2b\u643a\u5e26\u8005\u57fa\u56e0\u7b5b\u67e5\u65b0\u7b56\u7565\uff0c\u8d1d\u745e\u57fa\u56e0\u6b63\u5f0f\u53d1\u8d77\u201c\u5730\u4e2d\u6d77\u8d2b\u8840\u57fa\u56e0\u56fe\u8c31\u8ba1\u5212TiGA\uff08Thalassemia Gene Atlas\uff09\u201d\u3002\u8be5\u8ba1\u5212\u65e8\u5728\u901a\u8fc7\u4e0e\u56fd\u5185\u5730\u4e2d\u6d77\u8d2b\u8840\u9632\u63a7\u4e34\u5e8a\u4e13\u5bb6\u5408\u4f5c\uff0c\u5145\u5206\u5229\u7528Pacbio Sequel II\u7b2c\u4e09\u4ee3\u6d4b\u5e8f\u5355\u5206\u5b50\u5b9e\u65f6\u6d4b\u5e8f\u6280\u672f\u548c\u5f3a\u5927\u7684\u751f\u7269\u4fe1\u606f\u5206\u6790\u80fd\u529b\uff0c\u6df1\u5165\u6316\u6398\u6211\u56fd\u4e30\u5bcc\u7684\u5730\u4e2d\u6d77\u8d2b\u8840\u9057\u4f20\u8d44\u6e90\uff0c\u63d0\u5347\u79d1\u5b66\u7814\u7a76\u7684\u6574\u4f53\u6c34\u5e73\uff0c\u8fdb\u4e00\u6b65\u5b8c\u5584\u4e2d\u56fd\u4eba\u7fa4\u7279\u6709\u7684\u5730\u8d2b\u6cbb\u75c5\u57fa\u56e0\u53d8\u5f02\u4e0e\u4e34\u5e8a\u8868\u578b\u6570\u636e\u5e93\uff0c\u4fc3\u8fdb\u5730\u8d2b\u8bca\u7597\u624b\u6bb5\u7684\u53d1\u5c55\u3002\u771f\u6b63\u52a9\u529b\u4e2d\u56fd\u5357\u65b9\u5730\u8d2b\u9ad8\u53d1\u7701\u4efd\u5b9e\u73b0\u7cbe\u51c6\u8131\u201c\u8d2b\u201d\u3002<\/div>\n
\u00a0<\/div>\n
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\u00a0<\/div>\n
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