{"id":8923,"date":"2021-03-28T22:53:30","date_gmt":"2021-03-28T14:53:30","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&mid=100018821&idx=1&sn=631cb1295f28f9e3ea2ab4fd96ffe5ba&chksm=6b7178325c06f1240bf2c691873a6fe6b0e9b798f45aee421d030dd46dba4216ce4b5d2214d8#rd"},"modified":"2026-04-01T15:43:26","modified_gmt":"2026-04-01T07:43:26","slug":"9810251","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2021\/03\/28\/9810251\/","title":{"rendered":"\u57fa\u56e0\u4ea7\u4e1a\u7b80\u62a5\uff08138\u671f\uff09"},"content":{"rendered":"
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\uff08\u6765\u6e90\/Cell\uff09<\/div>\n
\u5b8f\u89c2\u73af\u5883<\/div>\n
\u2756 \u56fd\u81ea\u7136\uff1a\u5c069\u4e2a\u79d1\u5b66\u90e8\u6574\u5408\u4e3a4\u4e2a\u677f\u5757<\/div>\n
2021\u5e743\u670824\u65e5\uff0c\u636e\u79d1\u5b66\u7f51\u62a5\u9053\uff0c\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u59d4\u5458\u4f1a\u7b2c\u516b\u5c4a\u59d4\u5458\u4f1a\u7b2c\u56db\u6b21\u5168\u4f53\u4f1a\u8bae\u5728\u5317\u4eac\u53ec\u5f00\u3002\u4f1a\u8bae\u4e0a\uff0c\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u59d4\u4e3b\u4efb\u3001\u515a\u7ec4\u4e66\u8bb0\u674e\u9759\u6d77\u4f5c\u5168\u59d4\u4f1a\u5de5\u4f5c\u62a5\u544a\u3002\u62a5\u544a\u6307\u51fa\uff0c\u5c06\u73b0\u67099\u4e2a\u79d1\u5b66\u90e8\u6574\u5408\u4e3a\u201c\u57fa\u7840\u79d1\u5b66\u3001\u6280\u672f\u79d1\u5b66\u3001\u751f\u547d\u4e0e\u533b\u5b66\u3001\u4ea4\u53c9\u878d\u5408\u201d4\u4e2a\u677f\u5757\u7684\u8d44\u52a9\u5e03\u5c40\uff0c\u63a8\u52a8\u79d1\u7814\u8303\u5f0f\u53d8\u9769\uff0c\u5b9e\u73b0\u8d44\u6e90\u4f18\u5316\u914d\u7f6e\u3002<\/div>\n
\u57fa\u7840\u79d1\u5b66\u677f\u5757\u5305\u62ec\u201c\u6570\u5b66\u3001\u529b\u5b66\u3001\u5929\u6587\u3001\u7269\u7406\u3001\u5316\u5b66\u3001\u5730\u5b66\u201d\u7b49\uff0c\u7740\u91cd\u9762\u5411\u4e16\u754c\u79d1\u6280\u524d\u6cbf\uff1b<\/div>\n
\u6280\u672f\u79d1\u5b66\u677f\u5757\u4e3b\u8981\u7531\u201c\u4fe1\u606f\u3001\u5de5\u7a0b\u3001\u6750\u6599\u201d\u7b49\u7ec4\u6210\uff0c\u7740\u91cd\u9762\u5411\u56fd\u5bb6\u91cd\u5927\u9700\u6c42\u548c\u7ecf\u6d4e\u4e3b\u6218\u573a\uff1b<\/div>\n
\u751f\u547d\u4e0e\u533b\u5b66\u677f\u5757\u4e3b\u8981\u7531\u201c\u751f\u7269\u5b66\u3001\u533b\u5b66\u3001\u519c\u4e1a\u79d1\u5b66\u201d\u7b49\u7ec4\u6210\uff0c\u7740\u91cd\u9762\u5411\u4e16\u754c\u79d1\u6280\u524d\u6cbf\u548c\u4eba\u6c11\u751f\u547d\u5065\u5eb7\uff1b<\/div>\n
\u4ea4\u53c9\u878d\u5408\u677f\u5757\u4e3b\u8981\u7531\u201c\u4ea4\u53c9\u3001\u7ba1\u7406\u201d\u7b49\u7ec4\u6210\u3002\u4ea4\u53c9\u4ee5\u91cd\u5927\u4ea4\u53c9\u79d1\u5b66\u95ee\u9898\u4e3a\u5bfc\u5411\uff0c\u63a2\u7d22\u65b0\u7684\u79d1\u5b66\u7814\u7a76\u8303\u5f0f\u548c\u652f\u6301\u4ea4\u53c9\u7814\u7a76\u7684\u65b0\u673a\u5236\u3002\u7ba1\u7406\u79d1\u5b66\u8981\u7edf\u7b79\u5b66\u79d1\u53d1\u5c55\u548c\u670d\u52a1\u793e\u4f1a\u7ecf\u6d4e\u53d1\u5c55\uff0c\u91cd\u89c6\u56fd\u5bb6\u6cbb\u7406\u4f53\u7cfb\u548c\u6cbb\u7406\u80fd\u529b\u73b0\u4ee3\u5316\u7684\u91cd\u5927\u9700\u6c42\u3002<\/div>\n
\u00a0<\/div>\n
\u2756 \u300a\u533b\u7597\u5668\u68b0\u76d1\u7763\u7ba1\u7406\u6761\u4f8b\u300b\u5b98\u65b9\u89e3\u8bfb<\/div>\n
2021\u5e743\u670826\u65e5\uff0c\u56fd\u52a1\u9662\u653f\u7b56\u4f8b\u884c\u5439\u98ce\u4f1a\u4e0a\uff0c\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u76f8\u5173\u8d1f\u8d23\u4eba\u4ecb\u7ecd\u300a\u533b\u7597\u5668\u68b0\u76d1\u7763\u7ba1\u7406\u6761\u4f8b\u300b\u6709\u5173\u60c5\u51b5\u3002\u636e\u4f1a\u8bae\u4ecb\u7ecd\uff1a<\/div>\n
\u76ee\u524d\u5168\u56fd\u6709\u533b\u7597\u5668\u68b0\u751f\u4ea7\u4f01\u4e1a2.5\u4e07\u591a\u5bb6\uff0c\u7ecf\u8425\u4f01\u4e1a89.7\u4e07\u591a\u5bb6\u30022019\u5e74\u5168\u56fd\u533b\u7597\u5668\u68b0\u4e3b\u8425\u4e1a\u6536\u5165\u8fbe\u52307200\u591a\u4ebf\u5143\uff0c\u7ea6\u5360\u5168\u7403\u533b\u7597\u5668\u68b0\u5e02\u573a\u89c4\u6a21\u768420%\u3002<\/div>\n
\u5168\u56fd\u533b\u7597\u5668\u68b0\u6ce8\u518c\u8bc1\u8fbe13.9\u4e07\u4ef6\uff0c\u5907\u6848\u533b\u7597\u5668\u68b0\u8fbe11.5\u4e07\u4ef6\uff0c\u6279\u51c6\u4e0a\u5e02\u7684\u521b\u65b0\u533b\u7597\u5668\u68b0\u5df2\u8fbe103\u4ef6\u3002<\/div>\n
\u5728\u76ee\u524d\u533b\u7597\u5668\u68b0\u5ba1\u8bc4\u5ba1\u6279\u5b9e\u8df5\u4e2d\uff0c\u9700\u8981\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u7684\uff0c\u5927\u7ea6\u53ea\u5360\u5230\u6574\u4e2a\u5ba1\u8bc4\u768412.5%\uff1b\u9700\u8981\u8fdb\u884c\u5176\u4ed6\u4e34\u5e8a\u8bc4\u4ef7\u7684\uff0c\u5927\u7ea6\u536042.5%\uff1b\u800c\u514d\u4e88\u8fdb\u884c\u4e34\u5e8a\u8bc4\u4ef7\u7684\uff0c\u5927\u7ea6\u536045%\uff08\u66f4\u591a\u8be6\u60c5\u89c1\u53c2\u8003\u94fe\u63a5\uff09\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/mp.weixin.qq.com\/s\/bZqskYcojposLxQp7gOQXA<\/div>\n
\u00a0<\/div>\n
\u2756 \u4eba\u9057\u8d44\u884c\u653f\u8bb8\u53ef2021\u5e74\u7b2c\u4e94\u6279\uff082.9-3.1\uff09\u5ba1\u6279\u7ed3\u679c<\/div>\n
2021\u5e743\u670822\u65e5\uff0c\u4e2d\u56fd\u4eba\u7c7b\u9057\u4f20\u8d44\u6e90\u884c\u653f\u8bb8\u53ef\u4e8b\u98792021\u5e74\u7b2c\u4e94\u6279\u5ba1\u6279\u7ed3\u679c\u516c\u5e03\u30022021\u5e742\u67089\u65e5-2021\u5e743\u67081\u65e5\u5171\u53d7\u7406\u884c\u653f\u8bb8\u53ef\u7533\u8bf7\u4e8b\u9879394\u9879\uff0c\u540c\u610f\u5f00\u5c55374\u9879\uff0c\u5176\u4e2d\uff0c\u91c7\u96c6\u884c\u653f\u8bb8\u53ef128\u9879\uff0c\u56fd\u9645\u5408\u4f5c\u79d1\u5b66\u7814\u7a76\u884c\u653f\u8bb8\u53ef246\u9879\u3002<\/div>\n
\u5176\u4e2d\u4e0e\u57fa\u56e0\u53ca\u6297\u4f53\u7b49\u76f8\u5173\u7684\u9879\u76ee\u4e3e\u4f8b\u5982\u4e0b\uff08\u66f4\u591a\u4fe1\u606f\u89c1\u53c2\u8003\u4fe1\u606f\u94fe\u63a5\uff09\uff1a<\/div>\n
\u57fa\u4e8e\u4e8c\u4ee3\u6d4b\u5e8f\u5e73\u53f0\u7684\u65e0\u521b\u7ed3\u76f4\u80a0\u764c\u65e9\u671f\u7b5b\u67e5\u7814\u7a76\uff0c\u4e2d\u5c71\u5927\u5b66\u9644\u5c5e\u7b2c\u516d\u533b\u9662<\/div>\n
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\u6839\u636e\u4e2d\u56fd\u4ebaLynch\u7efc\u5408\u5f81\u7b5b\u67e5\u6807\u51c6\u4f7f\u7528\u91d1\u6a61\u533b\u5b66\u9057\u4f20\u6027\u80bf\u7624\u57fa\u56e0\u68c0\u6d4b\u5e73\u53f0\u8bca\u65adLynch\u7efc\u5408\u5f81\u7684\u5f00\u653e\u6027\u3001\u5355\u4e2d\u5fc3\u7814\u7a76\uff0c\u6d59\u6c5f\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u7b2c\u4e8c\u533b\u9662<\/div>\n
\u4e91\u5357\u5f5d\u65cf\u9ad8\u8840\u538b\u60a3\u8005\u4ee3\u8c22\u7ec4\u5b66\u548c\u80a0\u9053\u83cc\u7fa4\u5b8f\u57fa\u56e0\u7ec4\u5b66\u5173\u8054\u7814\u7a76\u4e0e\u5e94\u7528\uff0c\u6606\u660e\u5e02\u5ef6\u5b89\u533b\u9662<\/div>\n
\u80bf\u7624\u591a\u57fa\u56e0\u68c0\u6d4b\u8bd5\u5242\u76d2\uff08\u8054\u5408\u63a2\u9488\u951a\u5b9a\u805a\u5408\u6d4b\u5e8f\u6cd5\uff09\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u5317\u4eac\u534f\u548c\u533b\u9662<\/div>\n
\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u653e\u7597\u76f8\u5173\u65b0\u6297\u539f\u548cbTMB\u7684\u52a8\u6001\u53d8\u5316\u8bc4\u4f30\uff0c\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u5317\u4eac\u534f\u548c\u533b\u9662\u3001\u963f\u65af\u5229\u5eb7\u6295\u8d44\uff08\u4e2d\u56fd\uff09\u6709\u9650\u516c\u53f8\u3001\u5357\u4eac\u4e16\u548c\u57fa\u56e0\u751f\u7269\u6280\u672f\u80a1\u4efd\u6709\u9650\u516c\u53f8\u3001\u4e0a\u6d77\u4e2d\u79d1\u65b0\u751f\u547d\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8<\/div>\n
\u4eba\u5faa\u73af\u80bf\u7624DNA\u591a\u57fa\u56e0\u7a81\u53d8\u8054\u5408\u68c0\u6d4b\u8bd5\u5242\u76d2\uff08\u98de\u884c\u65f6\u95f4\u8d28\u8c31\u6cd5\uff09\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5317\u4eac\u80bf\u7624\u533b\u9662\u4e2d\u6e90\u534f\u548c\uff08\u5929\u6d25\uff09\u533b\u5b66\u68c0\u9a8c\u6240\u6709\u9650\u516c\u53f8\u3001\u5317\u4eac\u6c34\u6728\u83c1\u521b\u533b\u836f\u79d1\u6280\u6709\u9650\u516c\u53f8\u3001\u5317\u4eac\u5409\u56e0\u52a0\u533b\u5b66\u68c0\u9a8c\u5b9e\u9a8c\u5ba4\u6709\u9650\u516c\u53f8<\/div>\n
\u8bc4\u4ef7AZD4547\u5728\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u53ca\u5bf9\u5b58\u5728FGFR2\/3\u57fa\u56e0\u6539\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\u6709\u6548\u6027\u7684Ib\/II\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u3001\u4e0a\u6d77\u548c\u8a89\u751f\u7269\u533b\u836f\u79d1\u6280\u6709\u9650\u516c\u53f8\u3001\u676d\u5dde\u6cf0\u683c\u533b\u836f\u79d1\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8\u3001\u5e7f\u5dde\u71c3\u77f3\u533b\u5b66\u68c0\u9a8c\u6240\u6709\u9650\u516c\u53f8\u3001\u7cbe\u9f0e\u533b\u836f\u7814\u7a76\u5f00\u53d1\uff08\u4e0a\u6d77\uff09\u6709\u9650\u516c\u53f8\u3001\u4e0a\u6d77\u836f\u660e\u5eb7\u5fb7\u65b0\u836f\u5f00\u53d1\u6709\u9650\u516c\u53f8<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/fuwu.most.gov.cn\/html\/tztg\/xzxkzx\/20210322\/123123760.html<\/div>\n
\u00a0<\/div>\n
\u524d\u6cbf\u6280\u672f<\/div>\n
\u2756\u00a0Cell\uff1a\u65b0\u51a0\u53d8\u5f02\u682a\u901a\u8fc7\u75ab\u82d7\u8bf1\u5bfc\u7684\u4f53\u6db2\u514d\u75ab\u9003\u907f\u4e2d\u548c<\/div>\n
\u8fd1\u65e5\uff0cCell\u62a5\u9053\u4e86\u4e00\u9879\u7814\u7a76\u6210\u679c\uff0c\u5168\u7403\u8303\u56f4\u5185\u5df2\u7ecf\u51fa\u73b0\u4e86\u8bb8\u591a\u79cd\u65b0\u51a0\u75c5\u6bd2\u53d8\u5f02\u682a\uff0c\u901a\u8fc7\u75ab\u82d7\u8bf1\u5bfc\u7684\u4f53\u6db2\u514d\u75ab\u9003\u907f\u4e2d\u548c\uff0c\u7279\u522b\u662fmRNA\u75ab\u82d7\u5f15\u53d1\u9488\u5bf9\u540c\u6e90\u5047\u75c5\u6bd2\u7684\u6709\u6548\u4e2d\u548c\u6d3b\u6027\uff1b\u5177\u6709\u53d7\u4f53\u7ed3\u5408\u7ed3\u6784\u57df\uff08RBD\uff09\u7a81\u53d8\u7684\u83cc\u682a\u7684\u4ea4\u53c9\u4e2d\u548c\u4f5c\u7528\u8f83\u5dee\u3002RBD\u548c\u975eRBD\u7a81\u53d8\u90fd\u4ecb\u5bfc\u75ab\u82d7\u8bf1\u5bfc\u7684\u4f53\u6db2\u514d\u75ab\u7684\u9003\u9038\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/doi.org\/10.1016\/j.cell.2021.03.013<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0Biological Psychiatry\uff1a\u5927\u89c4\u6a21\u57fa\u56e0\u7ec4\u7814\u7a76\u63ed\u793a\u4e3b\u8981\u7cbe\u795e\u75be\u75c5\u7684\u6027\u522b\u5dee\u5f02<\/div>\n
\u8fd1\u65e5\uff0c\u5728\u8fc4\u4eca\u4e3a\u6b62\u5df2\u77e5\u7684\u6709\u5173\u60c5\u7eea\u548c\u7cbe\u795e\u75c5\u7684\u6700\u5927\u7684\u57fa\u56e0\u7ec4\u5206\u6790\u7814\u7a76\u4e2d\uff0c\u4e00\u4e2a\u8de8\u56fd\u79d1\u5b66\u5bb6\u56e2\u961f\u5206\u6790\u4e86\u5927\u7ea620\u4e07\u4e2a\u57fa\u56e0\u7ec4\uff0c\u53d1\u73b0\u5c3d\u7ba1\u4e24\u6027\u4e4b\u95f4\u5b58\u5728\u5927\u91cf\u7684\u9057\u4f20\u91cd\u53e0\uff0c\u4f46\u5728\u4e0e\u795e\u7ecf\u5143\u53d1\u80b2\uff0c\u514d\u75ab\u548c\u8840\u7ba1\u529f\u80fd\u4f1a\u5f71\u54cd\u4e09\u79cd\u4e3b\u8981\u7684\u7cbe\u795e\u75be\u75c5\uff1a\u7cbe\u795e\u5206\u88c2\u75c7\uff0c\u8e81\u90c1\u75c7\u548c\u91cd\u5ea6\u6291\u90c1\u75c7\u3002\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u5728Biological Psychiatry\u671f\u520a\u3002\u4f5c\u8005\u8ba4\u4e3a\uff0c\u57fa\u56e0\u548c\u75c5\u7406\u751f\u7406\u5b66\u7684\u5f71\u54cd\u5c06\u5e2e\u52a9\u9488\u5bf9\u6027\u522b\u5236\u5b9a\u4e2a\u6027\u5316\u6cbb\u7597\u548c\u5e72\u9884\u63aa\u65bd\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0Nature\uff1a\u53d1\u73b0\u4eba\u7c7b\u80ce\u76d8\u7684\u57fa\u56e0\u7ec4\u7ed3\u6784\u7c7b\u4f3c\u4e8e\u80bf\u7624<\/div>\n
\u8fd1\u65e5\uff0c\u5251\u6865\u5927\u5b66\u548cWellcome Sanger\u7814\u7a76\u6240\u7684\u7814\u7a76\u4eba\u5458\u5728Nature\u53d1\u8868\u4e86\u9996\u4e2a\u4eba\u7c7b\u80ce\u76d8\u57fa\u56e0\u7ec4\u7ed3\u6784\u7814\u7a76\u7684\u6210\u679c\uff0c\u53d1\u73b0\u80ce\u76d8\u7684\u6b63\u5e38\u57fa\u56e0\u7ec4\u7ed3\u6784\u4e0e\u5176\u4ed6\u4eba\u7c7b\u5668\u5b98\u90fd\u4e0d\u76f8\u540c\uff0c\u800c\u662f\u7c7b\u4f3c\u4e8e\u80bf\u7624\uff0c\u5b58\u5728\u4e0e\u8bb8\u591a\u513f\u7ae5\u764c\u75c7\u76f8\u540c\u7684\u57fa\u56e0\u7a81\u53d8\u3002\u7814\u7a76\u53ef\u80fd\u4e3a\u66f4\u52a0\u6df1\u5165\u5730\u4e86\u89e3\u65e9\u4ea7\u548c\u6b7b\u4ea7\u7b49\u95ee\u9898\u63d0\u4f9b\u4e86\u65b0\u601d\u8def\uff08\u53c2\u8003\u201c\u5947\u70b9\u7f51\u201d\u62a5\u9053\uff09\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/doi.org\/10.1038\/s41586-021-03345-1<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0bioRxiv\uff1a\u8036\u9c81\u5927\u5b66\u6a0a\u8363\u56e2\u961f\u5f00\u53d1\u51fa\u7a7a\u95f4\u8868\u89c2\u7ec4\u5b66\u6280\u672f<\/div>\n
\u636e\u6d4b\u5e8f\u4e2d\u56fd\u62a5\u9053\uff0c\u7ee72020\u5e7411\u6708\u8036\u9c81\u5927\u5b66\u6a0a\u8363\u6559\u6388\u56e2\u961f\u5f00\u53d1\u4e86\u65b0\u578b\u7a7a\u95f4\u7ec4\u5b66\u6d4b\u5e8f\u6280\u672fDBiT-seq\u6b27\uff0c\u8fd1\u671f\u5728bioRxiv\u5728\u7ebf\u62a5\u9053\u4e86\u4e00\u79cd\u540d\u4e3ahsrChST-seq\u7684\u7a7a\u95f4\u8868\u89c2\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6280\u672f\uff0c\u5e76\u5229\u7528\u8be5\u6280\u672f\u5bf9\u5c0f\u9f20\u80da\u80ce\u6216\u55c5\u7403\u7684\u7a7a\u95f4\u67d3\u8272\u8d28\u72b6\u6001\u8fdb\u884c\u89e3\u6790\uff0c\u63ed\u793a\u4e86\u7ec4\u7ec7\u7c7b\u578b\u7279\u5f02\u6027\u7684\u8868\u89c2\u9057\u4f20\u8c03\u63a7\uff0c\u4e3a\u5177\u4f53\u7684\u7ec4\u7ec7\u7c7b\u578b\u63d0\u4f9b\u4e86\u66f4\u52a0\u5168\u9762\u7684\u7a7a\u95f4\u89e3\u6790\u7684\u5168\u57fa\u56e0\u7ec4\u8f6e\u5ed3\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/doi.org\/10.1101\/2021.03.11.434985<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0Cell\u7efc\u8ff0\uff1a\u57fa\u56e0\u7ec4\u5de5\u7a0b\u7528\u4e8e\u4f5c\u7269\u6539\u826f\u548c\u672a\u6765\u519c\u4e1a<\/div>\n\n
\n
\"RmFicvQBAkgBAFG7xzVwCJ9Dia0vwdZhXibTvCicfutDibtRvBpQ3z41wSsrKjPsbKiagyfRZTia5ibiaGpIGanWyQdtq3A\"\/<\/figure><\/div>\n\n
\u56fe\uff1a\u57fa\u56e0\u7ec4\u5de5\u7a0b\u7528\u4e8e\u4f5c\u7269\u6539\u826f\u548c\u672a\u6765\u519c\u4e1a<\/div>\n
\uff08\u6765\u6e90\/Cell\uff09<\/div>\n
2021\u5e743\u670818\u65e5\uff0cCell\u4e0a\u7ebf\u7efc\u8ff0\u6587\u7ae0\uff0c\u63cf\u8ff0\u57fa\u56e0\u7ec4\u5de5\u7a0b\u7528\u4e8e\u4f5c\u7269\u6539\u826f\u548c\u672a\u6765\u519c\u4e1a\u3002\u63d0\u5230\u57fa\u56e0\u7ec4\u7f16\u8f91\u5c06\u5f7b\u5e95\u6539\u53d8\u690d\u7269\u80b2\u79cd\uff0c\u5e76\u6709\u52a9\u4e8e\u786e\u4fdd\u5168\u7403\u7cae\u98df\u4f9b\u5e94\u3002\u00a0\u6587\u7ae0\u5c06\u91cd\u70b9\u4ecb\u7ecd\u65b0\u5f00\u53d1\u7684\u6280\u672f\uff0c\u540c\u65f6\u56de\u987e\u690d\u7269\u4e2d\u57fa\u56e0\u7ec4\u7f16\u8f91\u5de5\u5177\u7684\u5f00\u53d1\u548c\u5e94\u7528\uff1b\u63cf\u8ff0\u4e86\u57fa\u4e8e\u57fa\u56e0\u7ec4\u7f16\u8f91\u7684\u65b0\u690d\u7269\u80b2\u79cd\u7b56\u7565\uff0c\u5e76\u8ba8\u8bba\u4e86\u5b83\u4eec\u5bf9\u4f5c\u7269\u751f\u4ea7\u7684\u5f71\u54cd\uff0c\u91cd\u70b9\u4ecb\u7ecd\u4e86\u4f20\u7edf\u80b2\u79cd\u65e0\u6cd5\u5b9e\u73b0\u7684\u57fa\u4e8e\u57fa\u56e0\u7ec4\u7f16\u8f91\u7684\u690d\u7269\u6539\u826f\u7684\u6700\u65b0\u8fdb\u5c55\u3002\u00a0\u6b64\u5916\u8ba8\u8bba\u4e86\u57fa\u56e0\u7ec4\u7f16\u8f91\u9762\u4e34\u7684\u6311\u6218\uff0c\u5728\u5b9e\u73b0\u8fd9\u9879\u6280\u672f\u5bf9\u672a\u6765\u4f5c\u7269\u548c\u7cae\u98df\u751f\u4ea7\u7684\u5168\u90e8\u6f5c\u529b\u4e4b\u524d\uff0c\u5fc5\u987b\u514b\u670d\u8fd9\u4e9b\u6311\u6218\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/doi.org\/10.1016\/j.cell.2021.01.005<\/div>\n
\u00a0<\/div>\n
\u4ea7\u54c1\u5e94\u7528<\/div>\n
\u2756\u00a0FDA\u6279\u51c6\u4e86\u9488\u5bf9\u6210\u5e74\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u7684\u9996\u4e2a\u57fa\u4e8e\u7ec6\u80de\u7684\u57fa\u56e0\u7597\u6cd5<\/div>\n
2021\u5e743\u670827\u65e5\uff0cFDA\u6279\u51c6\u4e86\u9488\u5bf9\u6210\u5e74\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u7684\u9996\u4e2a\u57fa\u4e8e\u7ec6\u80de\u7684\u57fa\u56e0\u7597\u6cd5Abecma\uff08idecabtagene vicleucel\uff09\uff0c\u7528\u4e8e\u6cbb\u7597\u5bf9\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u65e0\u53cd\u5e94\u6216\u75be\u75c5\u7684\u6210\u5e74\u60a3\u8005\u3002Abecma\u662f\u4e00\u79cdB\u7ec6\u80de\u6210\u719f\u6297\u539f\uff08BCMA\uff09\u6307\u5bfc\u7684\u57fa\u56e0\u4fee\u9970\u7684\u81ea\u4f53\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CAR\uff09T\u7ec6\u80de\u7597\u6cd5\uff0c\u88abFDA\u6388\u4e88\u201c\u5b64\u513f\u836f\u548c\u7a81\u7834\u6027\u7597\u6cd5\u201d\u79f0\u53f7\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u4e0a\u6d77\u81ea\u4e3b\u7814\u53d1\u7684mRNA\u65b0\u51a0\u80ba\u708e\u75ab\u82d7I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u542f\u52a8<\/div>\n
2021\u5e743\u670825\u65e5\uff0c\u636e\u6f8e\u6e43\u62a5\u9053\uff0c\u4e00\u6b3e\u9488\u5bf9\u9884\u9632\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u80ba\u708e\u7684mRNA\u75ab\u82d7\u2160\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5f0f\u542f\u52a8\u3002\u8be5\u75ab\u82d7\u7531\u65af\u5fae\uff08\u4e0a\u6d77\uff09\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\u3001\u540c\u6d4e\u5927\u5b66\u9644\u5c5e\u4e1c\u65b9\u533b\u9662\u5408\u4f5c\u7814\u53d1\uff0c\u8be5\u9879\u76ee\u542f\u52a8\u4eea\u5f0f\u5728\u6811\u5170\uff08\u676d\u5dde\uff09\u533b\u9662\u4e3e\u884c\u3002mRNA\u75ab\u82d7\u539f\u7406\u662f\u8ba9mRNA\u7f16\u7801\u75c5\u6bd2\u7684\u6297\u539f\u86cb\u767d\u5e8f\u5217\u3002mRNA \u5728\u8fdb\u5165\u4eba\u4f53\u7ec6\u80de\u5185\u540e\uff0c\u4f1a\u88ab\u4eba\u4f53\u7ec6\u80de\u4f5c\u4e3a\u6a21\u677f\uff0c\u6765\u751f\u4ea7\u75c5\u6bd2\u7684\u6297\u539f\u86cb\u767d\uff0c\u540c\u65f6\u6fc0\u6d3b\u4eba\u4f53\u7684\u4f53\u6db2\u514d\u75ab\u548c\u7ec6\u80de\u514d\u75ab\uff0c\u4ea7\u751f\u4fdd\u62a4\u6027\u6297\u4f53\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u56fd\u5185\u9996\u4e2aRET\u6291\u5236\u5242\u83b7\u6279\uff0c\u71c3\u77f3\u5408\u4f5c\u5f00\u53d1\u5176\u4f34\u968f\u8bca\u65ad<\/div>\n
2021\u5e743\u670824\u65e5\uff0c\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u901a\u8fc7\u4f18\u5148\u5ba1\u8bc4\u5ba1\u6279\u7a0b\u5e8f\u9644\u6761\u4ef6\u6279\u51c6\u57fa\u77f3\u836f\u4e1a\u666e\u62c9\u66ff\u5c3c\uff08Pralsetinib\uff09\u80f6\u56ca\u4ee5\u5546\u54c1\u540d\u666e\u5409\u534e\u4e0a\u5e02\uff0c\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u542b\u94c2\u5316\u7597\u7684\u8f6c\u67d3\u91cd\u6392\uff08RET\uff09\u57fa\u56e0\u878d\u5408\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u6210\u4eba\u60a3\u8005\u3002\u8fd9\u662f\u56fd\u5185\u83b7\u6279\u7684\u9996\u4e2aRET\u6291\u5236\u5242\uff0c\u662f\u57fa\u77f3\u836f\u4e1a\u5728IPO\u4e24\u5e74\u540e\u8fce\u6765\u7684\u9996\u4e2a\u5546\u4e1a\u5316\u4ea7\u54c1\u3002\u65e9\u57282020\u5e749\u6708\uff0c\u666e\u62c9\u66ff\u5c3c\uff08Pralsetinib\uff09\u83b7\u5f97FDA\u6279\u51c6\u30022020\u5e746\u6708\uff0c\u71c3\u77f3\u5408\u4f5c\u4e0e\u57fa\u77f3\u836f\u4e1a\u5408\u4f5c\u5f00\u53d1Pralsetinib\u7684\u4f34\u968f\u8bca\u65ad\uff0c\u8fd1\u671f\u63a8\u51faOncoScreen Mate (DNA+RNA) \u878d\u5408\u68c0\u6d4b\u4ea7\u54c1\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u9646\u821c\u6559\u6388\u518d\u6b21\u643a\u624b\u5409\u56e0\u52a0\u542f\u52a8\u665a\u671fNSCLC\u524d\u77bb\u6027\u4e34\u5e8a\u7814\u7a76\u9879\u76ee<\/div>\n
\u7ee72020\u5e74\uff0c\u5409\u56e0\u52a0\u548c\u9646\u821c\u6559\u6388\u5408\u4f5c\u9762\u5411EGFR\u9633\u6027\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u524d\u77bb\u6027\u4e34\u5e8a\u7814\u7a76TRACELib001\u5728Clinical Cancer Research\uff08IF=10.107\uff09\u53d1\u8868\u6210\u679c\u540e\uff0c2021\u5e744\u6708\uff0c\u9646\u821c\u6559\u6388\u5c06\u518d\u6b21\u643a\u624b\u5409\u56e0\u52a0\uff0c\u8054\u5408\u5168\u56fd\u591a\u5bb6\u80bf\u7624\u4e2d\u5fc3\uff0c\u9762\u5411\u665a\u671fNSCLC\u9a71\u52a8\u57fa\u56e0\u9634\u6027\u60a3\u8005\uff0c\u542f\u52a8TRACELib002\u9879\u76ee\uff08NCT04566432\uff09\uff0c\u65e8\u5728\u901a\u8fc7\u201c\u591a\u7ef4\u68c0\u6d4b+\u52a8\u6001\u76d1\u6d4b\u201d\u7684\u7406\u5ff5\uff0c\u63a2\u7d22\u514d\u75ab\u6cbb\u7597\u4e0b\u80bf\u7624\u514b\u9686\u6f14\u5316\u53ca\u5206\u5b50\u6807\u8bb0\u7269\u4e0e\u7597\u6548\u7684\u5173\u7cfb\uff0c\u7b5b\u9009\u514d\u75ab\u6cbb\u7597\u957f\u83b7\u76ca\u4eba\u7fa4\uff0c\u6700\u7ec8\u5efa\u7acb\u57fa\u4e8e\u6db2\u4f53\u6d3b\u68c0\u6280\u672f\u7684\u4e2d\u56fd\u4eba\u514d\u75ab\u6cbb\u7597\u591a\u7ef4\u9884\u6d4b\u6a21\u578b\u3002\u9879\u76ee\u4e00\u7ecf\u542f\u52a8\uff0c\u5df2\u6709\u81f3\u5c1135\u5bb6\u533b\u7597\u4e2d\u5fc3\u52a0\u5165\uff0c2021\u5e744\u67082\u65e5\uff0cTRACELib002\u9996\u573a\u542f\u52a8\u4f1a\u8bae-\u66a8\u5317\u4eac\u7ad9\u542f\u52a8\u4f1a\u5c06\u9686\u91cd\u5f00\u542f<\/div>\n
\u00a0<\/div>\n
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