{"id":8922,"date":"2021-04-04T21:58:52","date_gmt":"2021-04-04T13:58:52","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&mid=100018830&idx=1&sn=ddb4f116477e4d5df4720b5993278fc2&chksm=6b7178395c06f12f3af07fbfdf1453fc95aa7dd30a4bfa962902b07048425fc8eb23c874be4d#rd"},"modified":"2026-04-01T15:11:45","modified_gmt":"2026-04-01T07:11:45","slug":"4850101","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2021\/04\/04\/4850101\/","title":{"rendered":"\u57fa\u56e0\u884c\u4e1a\u7b80\u62a5\uff08139\u671f\uff09"},"content":{"rendered":"
\n
\"RmFicvQBAkgD6gMN4ZwPyAib6icCjdfiayLOBTuE0Pxk374fpb6hr6HR2OCN3xKYjAkDWj4syLfpwGGcjAvKT9GZAQ\"\/<\/figure><\/div>\n\n
\u56fe\uff1a\u5149\u5b66\u663e\u5fae\u955c\u4e0b\u5408\u6210\u7ec6\u80de\u751f\u957f\u548c\u5206\u88c2\u7684\u8fc7\u7a0b\uff08\u6765\u6e90\/Cell\uff09<\/div>\n
\u5b8f\u89c2\u73af\u5883<\/div>\n
\u2756 \u56fd\u53d1\u6539\u3001\u79d1\u6280\u90e8\u7b4913\u90e8\u95e8\u8054\u5408\u53d1\u5e03\uff1a\u53d1\u5c55\u79d1\u6280\u54a8\u8be2\uff0c\u5236\u9020\u4e1a\u54c1\u724c\u5efa\u8bbe\u548c\u5e02\u573a\u63a8\u5e7f<\/div>\n
2021\u5e743\u670826\u65e5\uff0c\u56fd\u5bb6\u53d1\u6539\u59d4\u3001\u79d1\u6280\u90e8\u7b4913\u90e8\u95e8\u8054\u5408\u53d1\u5e03\u300a\u5173\u4e8e\u52a0\u5feb\u63a8\u52a8\u5236\u9020\u670d\u52a1\u4e1a\u9ad8\u8d28\u91cf\u53d1\u5c55\u7684\u610f\u89c1\u300b\uff0c\u63d0\u51fa\u53d1\u5c55\u7814\u7a76\u5f00\u53d1\u3001\u6280\u672f\u8f6c\u79fb\u3001\u521b\u4e1a\u5b75\u5316\u3001\u77e5\u8bc6\u4ea7\u6743\u3001\u79d1\u6280\u54a8\u8be2\u7b49\u79d1\u6280\u670d\u52a1\u4e1a\uff0c\u52a0\u5f3a\u5173\u952e\u6838\u5fc3\u6280\u672f\u653b\u5173\uff0c\u52a0\u901f\u79d1\u6280\u6210\u679c\u8f6c\u5316\uff1b\u9f13\u52b1\u4e13\u4e1a\u670d\u52a1\u673a\u6784\u79ef\u6781\u53c2\u4e0e\u5236\u9020\u4e1a\u54c1\u724c\u5efa\u8bbe\u548c\u5e02\u573a\u63a8\u5e7f\uff0c\u52a0\u5f3a\u54c1\u724c\u548c\u8425\u9500\u7ba1\u7406\u670d\u52a1\uff0c\u63d0\u5347\u5236\u9020\u4e1a\u54c1\u724c\u6548\u5e94\u548c\u5e02\u573a\u7ade\u4e89\u529b\uff1b\u5229\u75285G\u3001\u5927\u6570\u636e\u3001\u4e91\u8ba1\u7b97\u3001\u4eba\u5de5\u667a\u80fd\u3001\u533a\u5757\u94fe\u7b49\u65b0\u4e00\u4ee3\u4fe1\u606f\u6280\u672f\uff0c\u5927\u529b\u53d1\u5c55\u667a\u80fd\u5236\u9020\u7b49\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>http:\/\/www.gov.cn\/zhengce\/zhengceku\/2021-03\/23\/content_5595161.htm<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u56fd\u5bb6\u6807\u51c6\u5316\u7ba1\u7406\u59d4\u5458\u4f1a\uff1a\u63a8\u8fdb\u9ad8\u901a\u91cf\u6d4b\u5e8f\u7b49\u65b0\u578b\u5206\u5b50\u8bca\u65ad\u6280\u672f\u7b49\u9886\u57df\u6807\u51c6\u5236\u4fee\u8ba2<\/div>\n
2021\u5e743\u670830\u65e5\uff0c\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u3001\u56fd\u5bb6\u6807\u51c6\u5316\u7ba1\u7406\u59d4\u5458\u4f1a\u53d1\u5e03\u300a\u5173\u4e8e\u8fdb\u4e00\u6b65\u4fc3\u8fdb\u533b\u7597\u5668\u68b0\u6807\u51c6\u5316\u5de5\u4f5c\u9ad8\u8d28\u91cf\u53d1\u5c55\u7684\u610f\u89c1\u300b\uff0c\u5176\u4e2d\u63d0\u51fa\u63a8\u8fdb\u9ad8\u901a\u91cf\u6d4b\u5e8f\u7b49\u65b0\u578b\u5206\u5b50\u8bca\u65ad\u6280\u672f\u3001\u4e34\u5e8a\u8d28\u8c31\u6280\u672f\u3001\u4f34\u968f\u8bca\u65ad\u8bd5\u5242\u3001\u5373\u65f6\u68c0\u9a8c\u3001\u6eaf\u6e90\u548c\u53c2\u8003\u6d4b\u91cf\u7cfb\u7edf\u7b49\u9886\u57df\u6807\u51c6\u5236\u4fee\u8ba2\u5de5\u4f5c\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0Guardant Health\u7684MRD\u68c0\u6d4b\u83b7\u5f97\u7ebd\u7ea6\u5dde\u7684\u6279\u51c6<\/div>\n
\u5f53\u5730\u65f6\u95f42021\u5e744\u67081\u65e5\uff0cGuardant Health\u8868\u793a\uff0c\u7ebd\u7ea6\u5dde\u536b\u751f\u90e8\u4e34\u5e8a\u5b9e\u9a8c\u5ba4\u8bc4\u4f30\u90e8\u95e8\uff08CLEP\uff09\u6279\u51c6\u4e86\u65d7\u4e0b\u6db2\u4f53\u6d3b\u68c0\u65b9\u6cd5Guardant Reveal\uff0c\u7528\u4e8e\u68c0\u6d4b\u548c\u76d1\u6d4b\u65e9\u671f\u764c\u75c7\u60a3\u8005\u7684MRD\uff08minimal residual disease\uff0c\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\uff09\u3002\u8be5\u5206\u6790\u65b9\u6cd5\u4e8e\u4eca\u5e742\u6708\u63a8\u51fa\uff0c\u57fa\u4e8ectDNA\u7684\u57fa\u56e0\u7a81\u53d8\u548c\u8868\u89c2\u9057\u4f20\u4fe1\u53f7\u68c0\u6d4b\uff0c\u5728\u60a3\u8005\u8fdb\u884c\u624b\u672f\u540e\u8bc6\u522b\u53ef\u80fd\u4ece\u8f85\u52a9\u6cbb\u7597\u4e2d\u53d7\u76caMRD\u7684\u60a3\u8005\uff0c\u5e76\u76d1\u6d4b\u590d\u53d1\u60c5\u51b5\uff0c\u5c06\u4ece\u7ed3\u76f4\u80a0\u764c\u5f00\u59cb\u5c06\u9010\u6b65\u6269\u5c55\u5230\u5176\u4ed6\u764c\u79cd\u3002Reveal\u5728\u68c0\u6d4b\u4e03\u79cd\u764c\u75c7\u7c7b\u578b\u7684ctDNA MRD\u65b9\u9762\u663e\u793a\u51fa91\uff05\u7684\u654f\u611f\u6027\u3002\u7ecf\u8fc7\u5305\u62ec\u8ffd\u8e2a\u4e861,400\u540dII\u671f\u7ed3\u80a0\u764c\u60a3\u8005\u7b49\u524d\u77bb\u6027\u8bd5\u9a8c\u7684\u9a8c\u8bc1\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u7f8e\u56fd\u8054\u90a6\u8d38\u6613\u59d4\u5458\u4f1a\u6b32\u963b\u6b62Illumina\u6536\u8d2dGrail\uff0cIllumina\u8868\u793a\u53cd\u5bf9\uff0c\u5e76\u627f\u8bfa\u5c06\u57282025\u5e74\u5c06\u4ef7\u683c\u964d\u4f4e40%\u4ee5\u4e0a<\/div>\n
\u5f53\u5730\u65f6\u95f42021\u5e743\u670830\u65e5\uff0c\u7ee72020\u5e749\u670821\u65e5Illumina\u63d0\u51fa\u5c06\u6536\u8d2dGrail\u540e\uff0c\u7f8e\u56fd\u8054\u90a6\u8d38\u6613\u59d4\u5458\u4f1a\uff08FTC\uff09\u6253\u7b97\u5bf9Illumina\u65a5\u8d4480\u4ebf\u7f8e\u5143\u6536\u8d2d\u6db2\u4f53\u6d3b\u68c0\u516c\u53f8Grail\u7684\u8ba1\u5212\u63d0\u51fa\u8d28\u7591\uff0cFTC\u5728\u4e00\u4efd\u58f0\u660e\u4e2d\u8868\u793a\uff0c\u8be5\u4ea4\u6613\u5c06\u524a\u5f31\u7f8e\u56fd\u591a\u764c\u79cd\u65e9\u8bca\u68c0\u6d4b\u7684\u521b\u65b0\u80fd\u529b\uff0c\u56e0\u4e3aIllumina\u7684NGS\u5e73\u53f0\u662f\u8fd9\u7c7b\u578b\u68c0\u6d4b\u7684\u552f\u4e00\u53ef\u884c\u9009\u62e9\u3002FTC\u5c06\u5728\u7f8e\u56fd\u54e5\u4f26\u6bd4\u4e9a\u7279\u533a\u5730\u65b9\u6cd5\u9662\u63d0\u8d77\u8bc9\u8bbc\uff0c\u8981\u6c42\u6cd5\u9662\u5bfb\u6c42\u4e34\u65f6\u9650\u5236\u4ee4\u548c\u521d\u6b65\u7981\u4ee4\uff0c\u4ee5\u4e2d\u6b62\u4ea4\u6613\u5e76\u7b49\u5f85\u884c\u653f\u5ba1\u5224\uff0c\u8be5\u8ba1\u5212\u5c06\u4e8e2021\u5e748\u670824\u65e5\u5f00\u59cb\u3002<\/div>\n
Illumina\u8868\u793a\u53cd\u5bf9\u8fd9\u9879\u8d28\u7591\uff0c\u5e76\u627f\u8bfa\u5728\u6536\u8d2d\u5b8c\u6210\u540e\u7684\u516d\u5e74\u5185\uff0c\u90fd\u4f1a\u5411\u7f8e\u56fd\u6240\u6709\u4e34\u5e8a\u80bf\u7624\u5ba2\u6237\u63d0\u4f9b\u5e73\u7b49\u548c\u516c\u6b63\u7684\u6d4b\u5e8f\u670d\u52a1\uff0c\u5e76\u627f\u8bfa\u52302025\u5e74\u5c06\u4ef7\u683c\u964d\u4f4e40\uff05\u4ee5\u4e0a\u3002\u00a0\u5728\u7eb3\u65af\u8fbe\u514b\u5e02\u573a\u7684\u4e0b\u5348\u4ea4\u6613\u4e2dIllumina\u7684\u80a1\u7968\u4e0b\u8dcc6\uff05\u81f3370.53\u7f8e\u5143\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u6e2f\u6fb3\u5408\u6cd5\u4e0a\u5e02\u7684\u975e\u5904\u65b9\u7c7b\u836f\u53ef\u5728\u5e7f\u5dde\u56fd\u9645\u533b\u836f\u6e2f\u9650\u989d\u9500\u552e<\/div>\n
2021\u5e743\u670826\u65e5\uff0c\u5e7f\u5dde\u5e02\u63a8\u8fdb\u7ca4\u6e2f\u6fb3\u5927\u6e7e\u533a\u5efa\u8bbe\u9886\u5bfc\u5c0f\u7ec4\u5370\u53d1\u4e86\u300a\u7ca4\u6e2f\u6fb3\u5927\u6e7e\u533a\u533b\u836f\u5065\u5eb7\u7efc\u5408\u8bd5\u9a8c\u533a\u5efa\u8bbe\u603b\u4f53\u65b9\u6848\u300b\uff08\u4ee5\u4e0b\u7b80\u79f0\u300a\u65b9\u6848\u300b\uff09\u3002\u5176\u4e2d\u660e\u786e\uff0c\u5728\u5e7f\u5dde\u56fd\u9645\u533b\u836f\u6e2f\u8bbe\u7acb\u533b\u836f\u7c7b\u5c0f\u989d\u5546\u54c1\u4ea4\u6613\u5e02\u573a\uff0c\u6e2f\u6fb3\u5408\u6cd5\u4e0a\u5e02\u7684\u975e\u5904\u65b9\u7c7b\u836f\u54c1\u53ef\u5728\u5e02\u573a\u5185\u9650\u989d\u9500\u552e\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u6df1\u5733\u533b\u5b66\u79d1\u5b66\u9662\u9009\u5740\u576a\u5c71\u533a<\/div>\n
2021\u5e744\u67081\u65e5\uff0c\u6df1\u5733\u5e02\u653f\u5e9c\u516c\u62a5\u5370\u53d1\u7684\u300a\u6df1\u5733\u533b\u5b66\u79d1\u5b66\u9662\u5efa\u8bbe\u65b9\u6848\u300b\u900f\u9732\uff0c\u6df1\u5733\u533b\u5b66\u79d1\u5b66\u9662\u9009\u5740\u576a\u5c71\u533a\uff0c\u6309\u7167\u201c\u8fb9\u5efa\u8bbe\uff0c\u8fb9\u8fd0\u884c\u201d\u6a21\u5f0f\u63a8\u8fdb\uff0c\u4e3b\u8981\u5efa\u8bbe\u201c\u56db\u5e73\u53f0\u4e00\u667a\u5e93\u201d\uff0c\u5e76\u7eb3\u5165\u4e2d\u56fd\u7279\u8272\u793e\u4f1a\u4e3b\u4e49\u5148\u884c\u793a\u8303\u533a\u7edf\u4e00\u8c0b\u5212\uff0c\u529b\u4e89\u5230\u672c\u4e16\u7eaa\u4e2d\u53f6\u6210\u4e3a\u5168\u7403\u8457\u540d\u533b\u5b66\u7814\u7a76\u673a\u6784\u3002\u201c\u56db\u5e73\u53f0\u4e00\u667a\u5e93\u201d\u5305\u542b\u5efa\u8bbe\u6574\u5408\u578b\u533b\u5b66\u79d1\u6280\u534f\u540c\u521b\u65b0\u5e73\u53f0\u3001\u5f00\u653e\u578b\u533b\u5b66\u79d1\u6280\u8d44\u6e90\u7ba1\u7406\u5e73\u53f0\u3001\u5f15\u9886\u578b\u533b\u5b66\u79d1\u6280\u57fa\u7840\u652f\u6491\u5e73\u53f0\u3001\u521b\u65b0\u578b\u533b\u5b66\u79d1\u6280\u4eba\u624d\u57f9\u80b2\u5e73\u53f0\u3001\u667a\u6167\u578b\u533b\u5b66\u79d1\u6280\u6218\u7565\u7814\u7a76\u667a\u5e93\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>http:\/\/fgw.gz.gov.cn\/gkmlpt\/content\/7\/7160\/post_7160068.html#481<\/div>\n
\u00a0<\/div>\n
\u524d\u6cbf\u6280\u672f<\/div>\n
\u2756 Science\uff1a\u91cc\u7a0b\u7891\u5de5\u4f5c\uff0c\u5f90\u5f66\u8f89\u56e2\u961f\u5168\u9762\u63ed\u793a\u8f6c\u5f55\u8d77\u59cb\u590d\u5408\u7269\u7684\u5de5\u4f5c\u673a\u5236<\/div>\n
2021\u5e744\u67082\u65e5\uff0c\u636eBioArt\u62a5\u9053\uff0cScience\u671f\u520a\u51e0\u4e4e\u662f\u4ee5\u53f2\u65e0\u524d\u4f8b\u7684\u7bc7\u5e45\uff088\u5e45\u4e3b\u56fe\uff0c39\u9875\u6b63\u6587\uff0c37\u5e45\u9644\u56fe\uff0c31\u4e2a\u89c6\u9891\u7b49\uff09\u53d1\u8868\u4e86\u590d\u65e6\u5927\u5b66\u5f90\u5f66\u8f89\u6559\u6388\u8bfe\u9898\u7ec4\u591a\u5e74\u7814\u7a76\u7684\u91cd\u5927\u6210\u679c\uff0c\u5229\u7528\u51b7\u51bb\u7535\u955c\u65b9\u6cd5\uff0c\u5168\u9762\u89e3\u6790\u4e86\u54fa\u4e73\u52a8\u7269\u8f6c\u5f55\u524d\u8d77\u59cb\u590d\u5408\u7269\u7ec4\u88c5\u8fc7\u7a0b\u4e2d\u6240\u6709\u5173\u952e\u7ec4\u88c5\u6b65\u9aa4\u548c\u72b6\u6001\u7684\u590d\u5408\u7269\u7ed3\u6784\uff0825\u4e2a\uff09\uff0c\u8fd9\u4e00\u53d1\u73b0\u8fd8\u98a0\u8986\u4e86\u7ecf\u5178\u6559\u79d1\u4e66\u4e2d\u5bf9TBP\uff08TATA box- binding protein\uff09\u53ea\u7ed3\u5408TATA box\u7684\u4f20\u7edf\u770b\u6cd5\uff0c\u4ece\u5206\u5b50\u6c34\u5e73\u5f88\u597d\u89e3\u91ca\u4e86\u8f6c\u5f55\u8d77\u59cb\u590d\u5408\u7269\u7ec4\u88c5\u548c\u57fa\u56e0\u8f6c\u5f55\u4e3a\u4f55\u53ef\u53d1\u751f\u5728\u51e0\u4e4e\u6240\u6709\u57fa\u56e0\u7684\u542f\u52a8\u5b50\u4e0a\u3002\u8be5\u9879\u5de5\u4f5c\u662f\u8fd1\u5e74\u6765\u8f6c\u5f55\u9886\u57df\u7684\u91cd\u8981\u7a81\u7834\uff0c\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\u5c55\u793a\u4e86\u9ad8\u5ea6\u52a8\u6001\u7684\u8f6c\u5f55\u8d77\u59cb\u8fc7\u7a0b\uff0c\u4e3a\u540e\u7eed\u7814\u7a76\u57fa\u56e0\u8868\u8fbe\u8c03\u63a7\u5960\u5b9a\u4e86\u7406\u8bba\u57fa\u7840\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/science.sciencemag.org\/content\/early\/2021\/03\/31\/science.aba8490.full<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0Nature Genetics\uff1a\u9ec4\u745b\/\u674e\u5927\u529b\u7b49\u9274\u5b9aSYK\u57fa\u56e0\u529f\u80fd\u83b7\u5f97\u6027\u7a81\u53d8\u5bfc\u81f4\u4eba\u7c7b\u514d\u75ab\u5931\u8c03<\/div>\n
2021\u5e743\u670829\u65e5\uff0c\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u513f\u79d1\u533b\u9662\u9ec4\u745b\u8bfe\u9898\u7ec4\u3001\u534e\u4e1c\u5e08\u8303\u5927\u5b66\u674e\u5927\u529b\u8bfe\u9898\u7ec4\u4ee5\u53ca\u52a0\u62ff\u5927\u591a\u4f26\u591a\u513f\u7ae5\u533b\u9662Aleixo M. Muise\u8bfe\u9898\u7ec4\u5171\u540c\u5728Nature Genetics\u6742\u5fd7\u5728\u7ebf\u53d1\u8868\u7814\u7a76\u8bba\u6587\uff0c\u63ed\u793a\u4e86SYK\u57fa\u56e0\u7684\u529f\u80fd\u83b7\u5f97\u6027\u7a81\u53d8\u4f1a\u5bfc\u81f4\u4eba\u53ca\u5c0f\u9f20\u514d\u75ab\u5931\u8c03\u548c\u5168\u8eab\u6027\u708e\u75c7\uff0c\u9610\u8ff0\u4e86\u76f8\u5173\u5206\u5b50\u673a\u5236\uff1b\u901a\u8fc7\u5bf9\u52a8\u7269\u6a21\u578b\u8fdb\u884c\u591a\u79cd\u5e72\u9884\uff0c\u9a8c\u8bc1\u4e86\u6cbb\u7597\u8be5\u75be\u75c5\u7684\u7b56\u7565\uff0c\u4e3a\u4e34\u5e8a\u4e0a\u6cbb\u7597\u56e0SYK\u529f\u80fd\u83b7\u5f97\u6027\u7a81\u53d8\u5f15\u8d77\u7684\u514d\u75ab\u5931\u8c03\u76f8\u5173\u75be\u75c5\u5960\u5b9a\u4e86\u57fa\u7840\uff08\u53c2\u8003\u201cBioArt\u201d\u516c\u4f17\u53f7\uff09\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/doi.org\/10.1038\/s41588-021-00803-4<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u7f8e\u56fdMIT\u7b49\u79d1\u5b66\u5bb6\u521b\u9020\u51fa\u53ef\u6b63\u5e38\u751f\u957f\u5206\u88c2\u7684\u4eba\u5de5\u5408\u6210\u7ec6\u80de<\/div>\n
2021\u5e743\u670829\u65e5\uff0c\u6765\u81ea\u7f8e\u56fd J. Craig Venter \u7814\u7a76\u6240\uff08JCVI\uff09\uff0c\u7f8e\u56fd\u56fd\u5bb6\u6807\u51c6\u4e0e\u6280\u672f\u7814\u7a76\u9662\uff08NIST\uff09\u4ee5\u53ca\u9ebb\u7701\u7406\u5de5\u5b66\u9662\uff08MIT\uff09\u7684\u7814\u7a76\u4eba\u5458\u8054\u5408\u5728Cell\u671f\u520a\u53d1\u5e03\u7814\u7a76\u6210\u679c\uff0c\u79f0\u6210\u529f\u521b\u9020\u51fa\u4e86\u4e00\u4e2a\u975e\u5e38\u7b80\u5355\u7684\u4eba\u5de5\u5408\u6210\u7ec6\u80de\uff0c\u8be5\u7ec6\u80de\u53ef\u4ee5\u6b63\u5e38\u751f\u957f\u548c\u5206\u88c2\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/doi.org\/10.1016\/j.cell.2021.03.008<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u6e05\u534e\u56e2\u961f\u6253\u9020\u5de5\u7a0b\u514d\u75ab\u7ec6\u80deSTAR-T\uff0c\u5e73\u53f0\u9996\u4e2a\u53cc\u9776\u70b9\u7597\u6cd5\u4e34\u5e8a\u7533\u62a5\u5728\u5373<\/div>\n
2021\u5e743 \u6708 24 \u65e5\uff0c\u00a0\u636e\u751f\u8f89\u62a5\u9053\uff0c\u6e05\u534e\u5927\u5b66\u6797\u6b23\u6559\u6388\u4e0e\u534e\u590f\u82f1\u6cf0\u8054\u5408\u521b\u59cb\u4eba\u8d75\u5b66\u5f3a\u535a\u58eb\u9886\u5bfc\u7684\u7814\u7a76\u56e2\u961f\u5728 Science \u5b50\u520a Science Translational Medicine \u4e0a\uff0c\u53d1\u8868\u4e86\u65b0\u578b\u5408\u6210 T \u7ec6\u80de\u7597\u6cd5 STAR-T \u7684\u6700\u65b0\u7814\u7a76\u8fdb\u5c55\u3002<\/div>\n
STAR-T\uff08Synthetic T cell receptor and antigen receptor\uff09\u878d\u5408\u4e86 CAR-T \u6280\u672f\u7684\u6297\u539f\u53d7\u4f53\u4ee5\u53ca TCR-T \u6280\u672f\u7684 T \u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\uff0c\u5176\u4e2d\u8bc6\u522b\u90e8\u5206\u4e3a\u6297\u539f\u53d7\u4f53\uff0c\u6052\u5b9a\u90e8\u5206\u662f\u53d6\u81ea TCR \u7684\u6052\u5b9a\u533a\u3002\u7814\u7a76\u8868\u660e\uff0cSTAR-T \u5f88\u597d\u5730\u5e73\u8861\u4e86\u514d\u75ab\u6740\u4f24\u80fd\u529b\u53ca\u6301\u4e45\u6027\uff0c\u5e76\u672a\u53d1\u73b0\u5728\u975e\u6297\u539f\u523a\u6fc0\u4e0b\u81ea\u6211\u6fc0\u6d3b\u7684\u60c5\u51b5\uff0c\u5728\u5b9e\u4f53\u7624\u7684\u6cbb\u7597\u4e2d\uff0cSTAR-T \u4f18\u4e8e CAR-T \u7597\u6cd5\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u65af\u5766\u798f\u79d1\u5b66\u5bb6\u5728 GitHub \u4e0a\u5f00\u6e90\u65b0\u51a0\u75ab\u82d7\u7684mRNA\u5e8f\u5217<\/div>\n
\u8fd1\u65e5\uff0c\u65af\u5766\u798f\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u5728 GitHub \u4e0a\u516c\u5e03\u4e86\u4e00\u4efd\u5305\u542b\u83ab\u5fb7\u7eb3\u65b0\u51a0\u75ab\u82d7 mRNA \u5e8f\u5217\u7684\u65b0\u6587\u4ef6\uff0c\u94fe\u63a5\u5982\u4e0b\u3002<\/div>\n
\u53c2\u8003\u4fe1\u606f>>https:\/\/github.com\/NAalytics\/Assemblies-of-putative-SARS-CoV2-spike-encoding-mRNA-sequences-for-vaccines-BNT-162b2-and-mRNA-1273<\/div>\n
\u00a0<\/div>\n
\u4ea7\u54c1\u5e94\u7528<\/div>\n
\u2756\u00a0\u534f\u548c\u5218\u4fca\u6d9b\uff1a\u4e34\u5e8a\u5b9e\u8df5\u5145\u5206\u8bc1\u5b9eCNV-seq\u662f\u65b0\u4e00\u4ee3\u4e00\u7ebf\u4ea7\u524d\u8bca\u65ad\u6280\u672f<\/div>\n
2021\u5e743\u670818\u65e5 \uff0c\u57282021\u5e74\u5317\u4eac\u5730\u533a\u5987\u4ea7\u79d1\u4e13\u4e1a\u5b66\u672f\u5e74\u4f1a\u4e0a\uff0c\u5317\u4eac\u534f\u548c\u533b\u9662\u7684\u4ea7\u79d1\u4e2d\u5fc3\u4e3b\u4efb\u5218\u4fca\u6d9b\u6559\u6388\uff0c\u5206\u4eab\u9ad8\u901a\u91cf\u6d4b\u5e8f\u5728\u4ea7\u524d\u8bca\u65ad\u4e34\u5e8a\u5e94\u7528\u4e2d\u7684\u53d1\u5c55\u548c\u8d8b\u52bf\uff0c\u63d0\u51fa:<\/div>\n
CNV-Seq\u662f\u6211\u56fd\u81ea\u4e3b\u7814\u53d1\u7684\u5e76\u7ecf\u8fc7\u4e34\u5e8a\u5b9e\u8df5\u5145\u5206\u8bc1\u660e\u7684\u65b0\u4e00\u4ee3\u4e00\u7ebf\u4ea7\u524d\u8bca\u65ad\u6280\u672f<\/div>\n
\u5728\u6ee1\u8db3\u57fa\u672c\u6d4b\u5e8f\u6df1\u5ea6\u7684\u524d\u63d0\u4e0b\uff0cCNV-Seq\u7684\u6838\u5fc3\u8d28\u63a7\u6807\u51c6\u662f\u552f\u4e00\u6bd4\u5bf9reads\u6570<\/div>\n
\u300a\u4f4e\u6df1\u5ea6\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6280\u672f\u5728\u4ea7\u524d\u8bca\u65ad\u4e2d\u7684\u5e94\u7528\u4e13\u5bb6\u5171\u8bc6\u300b\u63a8\u8350\u7684PCR-free\u5efa\u5e93\u65b9\u6cd5\u662fCNV-seq\u7cbe\u51c6\u68c0\u6d4b\u7684\u6280\u672f\u4fdd\u969c<\/div>\n
2021\u5e74\uff0c\u534f\u548c\u533b\u9662\u57fa\u4e8ePCR-free\u5f00\u53d1\u7684rCNV-seq\u6280\u672f\u66f4\u5feb\u3001\u66f4\u51c6\u3001\u66f4\u4fbf\u6377\u548c\u66f4\u7a33\u5b9a\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u56fd\u5185\u9996\u4e2a\u773c\u79d1\u4f53\u5185\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u6cbb\u7597LHON\u4e34\u5e8a\u8bd5\u9a8c\u8bb8\u53ef<\/div>\n
2021\u5e743\u670830\u65e5\uff0c\u7ebd\u798f\u65af\u751f\u7269\u5ba3\u5e03\u5176\u81ea\u4e3b\u7814\u53d1\u7684NR082\u773c\u7528\u6ce8\u5c04\u6db2\uff08rAAV-ND4\uff0c\u7814\u53d1\u4ee3\u53f7NFS-01\uff09\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u9881\u53d1\u7684\u6ce8\u518c\u6027\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\uff08IND\uff09\u8bb8\u53ef\uff0c\u5c06\u5728\u4e2d\u56fd\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u3002NR082\u662f\u56fd\u5185\u9996\u4e2a\u83b7\u5f97\u4e34\u5e8a\u8bd5\u9a8c\u8bb8\u53ef\u7684\u773c\u79d1\u4f53\u5185\u57fa\u56e0\u6cbb\u7597\u836f\u7269\uff0c\u5e76\u5df2\u4e8e2020\u5e749\u6708\u83b7\u5f97\u7f8e\u56fdFDA\u5b64\u513f\u836f\u8ba4\u5b9a\uff0c\u4e3a\u8be5\u4ea7\u54c1\u52a0\u901f\u56fd\u9645\u5316\u5f00\u53d1\u5960\u5b9a\u4e86\u57fa\u7840\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u5168\u7403\u7b2c\u4e94\u6b3eCAR-T\u4ea7\u54c1\u83b7\u6279<\/div>\n\n
\n
\"RmFicvQBAkgD6gMN4ZwPyAib6icCjdfiayLOXICFicZCQJKho3WAqxOdsG2yLvicyx09cw8rMZa9LdnccPPz1Pa07WNg\"\/<\/figure><\/div>\n\n
\u8868\uff1a\u5df2\u4e0a\u5e02\u7684CAR-T\u7ec6\u80de\u7597\u6cd5\uff08\u6765\u6e90\/E\u836f\u7ecf\u7406\u4eba\uff09<\/div>\n
3\u670827\u65e5\uff0cFDA\u5b98\u7f51\u53d1\u5e03\u516c\u544a\uff0c\u5df2\u6279\u51c6\u9996\u4e2a\u6cbb\u7597\u6210\u5e74\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u7684\u9776\u5411BCMA\u7684CAR-T\u7ec6\u80de\u7597\u6cd5Abecma\uff0c\u8fd9\u662f\u5168\u7403\u9996\u4e2a\u9776\u5411BCMA\u7684CAR-T\u7ec6\u80de\u7597\u6cd5\uff0c\u4e5f\u662f\u7b2c\u4e94\u6b3eCAR-T\u7ec6\u80de\u7597\u6cd5\u3002Abecma\u662f\u7531Bbluebird bio\u548cCelgene\u5171\u540c\u7814\u53d1\u7684\u4e00\u6b3e\u9776\u5411B\u7ec6\u80de\u6210\u719f\u6297\u539f\uff08BCMA\uff09\u7684CAR-T\u7ec6\u80de\u7597\u6cd5\u30022019\u5e741\u6708\uff0cBMS\u4ee5740\u4ebf\u7f8e\u5143\u4ef7\u683c\u6536\u8d2dCelgene\uff0c\u4ece\u800c\u83b7\u5f97\u4e86Abecma\uff08\u53c2\u8003\u201cE\u836f\u7ecf\u7406\u4eba\u201d\uff09\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u83f2\u9e4f\u751f\u7269\u63a8\u51fa\u9ad8\u901a\u91cf\u57fa\u56e0\u6d4b\u5e8f\u7cfb\u7edf<\/div>\n
2021\u5e743\u670828\u65e5\uff0c\u5728\u7b2c\u5341\u516b\u5c4a\u4e2d\u56fd\u56fd\u9645\u68c0\u9a8c\u533b\u5b66\u66a8\u8f93\u8840\u4eea\u5668\u8bd5\u5242\u535a\u89c8\u4f1a\uff08CACLP 2021\uff09\u4e0a\uff0c\u83f2\u9e4f\u751f\u7269\u63a8\u51fa\u5168\u65b0\u9ad8\u901a\u91cf\u57fa\u56e0\u6d4b\u5e8f\u7cfb\u7edfSeqQ 100\u3002\u7cfb\u7edf\u7684\u539f\u59cb\u6570\u636e\u4e2dQ30\u9ad8\u8d28\u91cf\u6570\u636e\u5360\u6bd4>80%\uff0c\u63d0\u4f9b\u4e30\u5bcc\u7684\u6d4b\u5e8f\u8bfb\u957f\u6a21\u5f0f\uff08SE35-PE150\uff09\u548c\u53cc\u89c4\u683c\u6d41\u52a8\u69fd\uff08100M\/400M\uff09\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u6c42\u81fb\u533b\u5b66\u3001\u4e16\u548c\u57fa\u56e0\u5c06\u501f\u52a9Illumina\u5e73\u53f0\u7533\u62a5\u9996\u6279\u6cdb\u764c\u79cd\u5927Panel<\/div>\n
2021\u5e743\u670828\u65e5\uff0c\u6c42\u81fb\u533b\u5b66\u521b\u59cb\u4eba&CEO\u5b59\u5927\u4f1f\u5148\u751f\u51fa\u5e2d\u56e0\u7f8e\u7eb3NextSeq\u2122 550Dx\u6d4b\u5e8f\u4eea\u53d1\u5e03\u4f1a\uff0c\u8868\u793a\u5c06\u8fd0\u7528NextSeq\u2122 550Dx\u6d4b\u5e8f\u5e73\u53f0\uff0c\u5f00\u53d1\u51fa\u66f4\u591a\u7b26\u5408\u4e2d\u56fd\u4e34\u5e8a\u9700\u6c42\u7684\u68c0\u6d4b\u4ea7\u54c1\uff0c\u63a8\u8fdbIVD\u8bd5\u5242\u76d2\u7684\u62a5\u6279\uff0c\u5c24\u5176\u662f\u9996\u6279\u6cdb\u764c\u79cd\u5927Panel\u57fa\u56e0\u6d4b\u5e8f\u8bd5\u5242\u76d2\u5728\u4e2d\u56fd\u7684\u843d\u5730\u30023\u670816\u65e5\uff0c\u4e16\u548c\u57fa\u56e0\u4e0eIllumina\u5ba3\u5e03\u8fbe\u6210\u5408\u4f5c\uff0c\u5c06\u57fa\u4e8eNextSeq\u2122 550Dx\u6d4b\u5e8f\u5e73\u53f0\u8fdb\u884cNGS\u5927panel \u4f53\u5916\u8bca\u65ad\u8bd5\u5242\u76d2\u7684\u5f00\u53d1\u3001\u6ce8\u518c\u4e0e\u5546\u4e1a\u5316\u3002<\/div>\n
\u00a0<\/div>\n
\u4ea7\u4e1a\u53d1\u5c55<\/div>\n
\u2756\u00a0\u7eb3\u7c73\u5b54\u6d4b\u5e8f\u4eea\u4f01\u4e1aOxford Nanopore\u5c06\u5728\u4f26\u6566\u4e0a\u5e02<\/div>\n
2021\u5e743\u670831\u65e5\uff0c\u636e\u5916\u5a92\u62a5\u9053\uff0cDNA\u6d4b\u5e8f\u6280\u672f\u521d\u521b\u4f01\u4e1aOxford Nanopore\u5c06\u9009\u62e9\u5728\u4eca\u5e74\u665a\u4e9b\u65f6\u5019\u5728\u4f26\u6566\u8bc1\u5238\u4ea4\u6613\u6240IPO\u3002\u76ee\u524d\u5206\u6790\u5e08\u5bf9\u5b83\u7684\u4f30\u503c\u572840-70\u4ebf\u82f1\u9551\u4e4b\u95f4\u3002\u82e5\u4e0a\u5e02\u6210\u529f\uff0cOxford Nanopore\u5c06\u6210\u4e3a\u7ee7Deliveroo\u4e4b\u540e\u7684\u7b2c\u4e00\u5bb6\u9009\u62e9\u5728\u4f26\u6566\u4e0a\u5e02\u7684\u79d1\u6280\u516c\u53f8\u3002\u76ee\u524d\u82f1\u56fd\u8bc1\u5238\u5b98\u5458\u4e5f\u5728\u5fd9\u4e8e\u6539\u9769\u4e0a\u5e02\u89c4\u5219\uff0c\u4ee5\u5438\u5f15\u66f4\u591a\u7684\u79d1\u6280\u4f01\u4e1a\u5728\u82f1\u56fd\u4e0a\u5e02\u3002Oxford Nanopore\u7684\u80a1\u4e1c\u5305\u62ec\u817e\u8baf\u3001\u65b0\u52a0\u5761\u4e3b\u6743\u8d22\u5bcc\u57fa\u91d1\u3001\u963f\u5e03\u624e\u6bd4\u79d1\u6280\u4e2d\u5fc3\uff0c\u4ee5\u53ca\u65bd\u7f57\u5fb7\u3001Odey Asset Management\u548cLansdowne\u7b49\u673a\u6784\u57fa\u91d1\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u963f\u65af\u5229\u5eb7\u7814\u53d1\u56e2\u961f\u7684\u5f52\u5bbf\u2014\u2014\u8fea\u54f2\u533b\u836fIPO\u7533\u8bf7\u83b7\u53d7\u7406<\/div>\n
2021\u5e743\u670810\u65e5\uff0c\u636e\u5065\u8bc6\u5c40\u62a5\u9053\uff0c\u8fea\u54f2\u533b\u836f\u5411\u4e0a\u4ea4\u6240\u63d0\u4ea4\u7684\u79d1\u521b\u677f\u4e0a\u5e02\u7533\u8bf7\u83b7\u5f97\u53d7\u7406\u30022017\u5e7411\u6708\uff0c\u963f\u65af\u5229\u5eb7\u5265\u79bb\u4e2d\u56fd\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u4e1a\u52a1\uff0c\u968f\u4e4b\u8fea\u54f2\u533b\u836f\u6210\u7acb\u3002\u963f\u65af\u5229\u5eb7\u539f\u6765\u7684\u4e2d\u56fd\u521b\u65b0\u4e2d\u5fc3\uff08ICC\uff09\u51e0\u4e4e\u6240\u6709\u7814\u53d1\u4eba\u5458\u5747\u52a0\u5165\u65b0\u516c\u53f8\uff0cICC\u8d1f\u8d23\u4eba\u5f20\u5c0f\u6797\u51fa\u4efb\u8fea\u54f2\u7684\u9996\u5e2d\u6267\u884c\u5b98\u3002\u963f\u65af\u5229\u5eb7\u4ee5\u83b7\u6279\u7684\u571f\u5730\u548c\u5b9e\u9a8c\u697c\u5165\u80a1\u8fea\u54f2\uff0c\u548c\u56fd\u6295\u521b\u65b0\u4e00\u8d77\uff0c\u6210\u4e3a\u8fea\u54f2\u7684\u5927\u80a1\u4e1c\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u601d\u8def\u8fea\u533b\u836f\u83b7\u65b0\u4e00\u4ee3CD47\u6297\u4f53\u65b0\u836f\u5927\u4e2d\u534e\u533a\u72ec\u5bb6\u6388\u6743<\/div>\n
2021\u5e743\u670831\u65e5\uff0c\u601d\u8def\u8fea\u533b\u836f(3D Medicines Inc.)\u5ba3\u5e03\u53d6\u5f97ImmuneOncia Therapeutics\u65b0\u4e00\u4ee3\u6297CD47\u5355\u514b\u9686\u6297\u4f53IMC-002\u80bf\u7624\u9002\u5e94\u75c7\u5728\u5927\u4e2d\u534e\u533a\u7684\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u7684\u72ec\u5bb6\u6388\u6743\u3002\u516c\u53f8\u8ba1\u5212\u4eca\u5e74\u5411NMPA\u63d0\u4ea4\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\uff08IND\uff09\u3002\u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0c\u601d\u8def\u8fea\u533b\u836f\u5c06\u652f\u4ed8800\u4e07\u7f8e\u5143\u7684\u9996\u4ed8\u6b3e\uff0c\u53ca\u672a\u6765\u6700\u9ad8\u8fbe4.625\u4ebf\u7f8e\u5143\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u5e76\u57fa\u4e8eIMC-002\u5728\u5927\u4e2d\u534e\u533a\u5e74\u5ea6\u51c0\u9500\u552e\u989d\u652f\u4ed8\u4e00\u5b9a\u6bd4\u4f8b\u9500\u552e\u7279\u8bb8\u4f7f\u7528\u8d39\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u78b3\u4e91\u667a\u80fd\u4e0eOlink Proteomics\u516c\u53f8\u5408\u4f5c\u63a8\u51fa\u9ad8\u901a\u91cf\u86cb\u767d\u8d28\u7ec4\u5b66\u7814\u7a76\u5e73\u53f0<\/div>\n
2021\u5e743\u6708\uff0c\u78b3\u4e91\u667a\u80fd\u5ba3\u5e03\u4e0e\u745e\u5178Olink Proteomics\u516c\u53f8\u8fbe\u6210\u6218\u7565\u5408\u4f5c\uff0c\u4e3a\u5e7f\u5927\u5b66\u8005\u3001\u79d1\u7814\u5de5\u4f5c\u8005\u5e26\u6765\u4e86\u4e00\u5957\u5168\u65b0\u7684\u9ad8\u901a\u91cf\u86cb\u767d\u8d28\u7ec4\u5b66\u7814\u7a76\u5e73\u53f0\u2014\u2014Olink\u5e73\u53f0\uff0c\u91c7\u7528\u4e86\u4e00\u79cd\u72ec\u6709\u7684\u79f0\u4e3a\u90bb\u8fd1\u5ef6\u4f38\u5206\u6790\uff08Proximity Extension Assay\uff0cPEA\uff09\u7684\u86cb\u767d\u8d28\u7ec4\u68c0\u6d4b\u6280\u672f\u3002\u78b3\u4e91\u76ee\u524d\u5df2\u7ecf\u5f15\u8fdb\u4e8614\u4e2a\u68c0\u6d4bpanel\uff0c\u6bcf\u4e2a panel \u4e2d\u5305\u542b 92 \u79cd\u86cb\u767d\u6807\u5fd7\u7269\uff0c\u5e76\u5229\u7528 Fluidigm qPCR \u5e73\u53f0\u8fdb\u884c\u68c0\u6d4b\u3002\u8fd9\u4e9bpanel\u5747\u5df2\u7ecf\u8fc7\u4e25\u683c\u9a8c\u8bc1\u548c\u4f18\u5316\uff0c\u8986\u76d61000\u591a\u4e2a\u86cb\u767d\u6807\u5fd7\u7269\u6297\u4f53\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u8c37\u6b4c\u524dCEO\u592b\u5987\u5411Broad\u6350\u8d601.5\u4ebf\u7f8e\u5143\uff0c\u7814\u7a76\u673a\u5668\u5b66\u4e60\u548c\u751f\u547d\u79d1\u5b66<\/div>\n
\u5f53\u5730\u65f6\u95f42021\u5e744\u67081\u65e5\uff0cMIT\u548c\u54c8\u4f5b\u521b\u5efa\u7684Broad\u7814\u7a76\u6240\u5ba3\u5e03\u542f\u52a8\u57c3\u91cc\u514b\u548c\u6e29\u8fea\u00b7\u65bd\u5bc6\u7279\u4e2d\u5fc3\uff0c\u8be5\u4e2d\u5fc3\u65e8\u5728\u901a\u8fc7\u6574\u5408\u673a\u5668\u5b66\u4e60\u548c\u751f\u547d\u79d1\u5b66\u6765\u4fc3\u8fdb\u4eba\u7c7b\u5065\u5eb7\u3002\u7531Google\u524d\u9996\u5e2d\u6267\u884c\u5b98\u57c3\u91cc\u514b\u00b7\u65bd\u5bc6\u7279\u548c\u4ed6\u7684\u59bb\u5b50\u3001\u5973\u5546\u4eba\u6e29\u8fea\u00b7\u65bd\u5bc6\u7279\u6350\u8d60\u76841.5\u4ebf\u7f8e\u5143\u6350\u8d60\u7684\u65bd\u5bc6\u7279\u4e2d\u5fc3\u521b\u7acb\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u8d1d\u5eb7\u533b\u7597\u4e0e\u534e\u5927\u667a\u9020\u8fbe\u6210\u6d4b\u5e8f\u4eea\u7814\u53d1\u5408\u4f5c\uff0c\u5171\u540c\u5f00\u53d1\u8f85\u52a9\u751f\u6b96\u4e0b\u4e00\u4ee3\u81ea\u52a8\u5316\u5b9e\u9a8c\u5e73\u53f0<\/div>\n
2021\u5e743\u670828\u65e5\uff0c\u4e0a\u5e02\u4f01\u4e1a\u82cf\u5dde\u8d1d\u5eb7\u533b\u7597\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff08\u80a1\u7968\u4ee3\u7801\uff1a2170 HK\uff09\u4e0e\u6df1\u5733\u534e\u5927\u667a\u9020\u79d1\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8\u8fbe\u6210\u6d4b\u5e8f\u4eea\u6218\u7565\u7814\u53d1\u5408\u4f5c\uff0c\u53cc\u65b9\u81f4\u529b\u4e8e\u5171\u540c\u5f00\u53d1\u8f85\u52a9\u751f\u6b96\u4e0b\u4e00\u4ee3\u81ea\u52a8\u5316\u5b9e\u9a8c\u5e73\u53f0\u89e3\u51b3\u65b9\u6848\u3002\u5176\u4e2d\u534e\u5927\u667a\u9020\u4f5c\u4e3a\u751f\u547d\u79d1\u5b66\u9886\u57df\u5168\u7403\u9886\u5148\u7684\u6d4b\u5e8f\u4eea\u7814\u53d1\u5236\u9020\u5546\uff0c\u5c06\u57fa\u4e8e\u80da\u80ce\u5355\u7ec6\u80de\u6c34\u5e73\u6d4b\u5e8f\u7814\u53d1\u56fd\u4ea7\u5316\u6d4b\u5e8f\u6280\u672f\uff1b\u8d1d\u5eb7\u533b\u7597\u5c06\u57fa\u4e8e\u5168\u7403\u9886\u5148\u7684\u80da\u80ce\u5355\u7ec6\u80de\u6269\u589eSDWGA\u6280\u672f\u53ca\u56fd\u5185\u7b2c\u4e00\u6b3e\u83b7\u5f97\u56fd\u5bb6\u4e09\u7c7b\u533b\u7597\u5668\u68b0\u6ce8\u518c\u8bc1\u7684PGT\u8bd5\u5242\u76d2\u7684\u64cd\u4f5c\u6d41\u7a0b\uff0c\u5f00\u53d1\u5168\u7403\u7b2c\u4e00\u4e2a\u80da\u80ce\u5355\u7ec6\u80de\u6c34\u5e73\u7684\u81ea\u52a8\u5316\u6d4b\u5e8f\u7cfb\u7edf\uff0c\u7ed3\u5408\u4eba\u5de5\u667a\u80fd\u6570\u636e\u5206\u6790\u548c\u62a5\u544a\u81ea\u52a8\u751f\u6210\u7cfb\u7edf\uff0c\u6253\u9020\u8f85\u52a9\u751f\u6b96\u4e0b\u4e00\u4ee3\u81ea\u52a8\u5316\u5b9e\u9a8c\u5e73\u53f0\u6574\u4f53\u89e3\u51b3\u65b9\u6848\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u5b89\u5e8f\u6e90\u751f\u7269\u79d1\u6280\u5b8c\u6210\u6536\u8d2d\u4fc4\u7f57\u65afGeneris Biotech\u516c\u53f8<\/div>\n
2021\u5e743\u670830\u65e5\uff0c\u534a\u5bfc\u4f53\u751f\u7269\u82af\u7247\u7814\u53d1\u4f01\u4e1a\u5b89\u5e8f\u6e90\u751f\u7269\u79d1\u6280\uff08Axbio\uff09\u8fd1\u65e5\u5ba3\u5e03\u5b8c\u6210\u6536\u8d2d\u4fc4\u7f57\u65afGeneris Biotech\u516c\u53f8\uff0c\u53cc\u65b9\u5c06\u5c31Axbio\u7684\u82af\u7247\u5e73\u53f0\u5728\u6b27\u6d32\u5e02\u573a\u7684\u63a8\u5e7f\u53ca\u843d\u5730\u5f00\u5c55\u5168\u65b9\u4f4d\u6df1\u5ea6\u5408\u4f5c\u3002\u901a\u8fc7Generis\uff0c\u5b89\u5e8f\u6e90\u5c06\u53ef\u76f4\u63a5\u8fdb\u51651.45\u4ebf\u4eba\u53e3\u7684\u4fc4\u7f57\u65af\u5e02\u573a\u548c2.8\u4ebf\u4eba\u53e3\u7684\u524d\u72ec\u8054\u4f53\u5e02\u573a\uff0c\u5e76\u4ee5\u6b64\u4e3a\u8d77\u70b9\u8f90\u5c04\u6574\u4e2a\u6b27\u6d32\u5e02\u573a\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u514d\u75ab\u5206\u6790\u516c\u53f8Immunai\u6536\u8d2d\u5355\u7ec6\u80de\u57fa\u56e0\u7ec4\u5b66\u8f6f\u4ef6\u516c\u53f8Dropprint Genomics<\/div>\n
2021\u5e744\u67081\u65e5\uff0c\u514d\u75ab\u5206\u6790\u516c\u53f8Immunai\u8868\u793a\u5df2\u6536\u8d2d\u5355\u7ec6\u80de\u57fa\u56e0\u7ec4\u5b66\u8f6f\u4ef6\u516c\u53f8Dropprint Genomics\uff0c\u6536\u8d2d\u91d1\u989d\u672a\u516c\u5f00\u3002\u00a0\u7531Y Combinator\u652f\u6301\u7684\u521d\u521b\u516c\u53f8Dropprint\u5efa\u7acb\u4e86\u6765\u81ea\u81ea\u8eab\u514d\u75ab\u548c\u764c\u75c7\u60a3\u8005\u7684\u514d\u75ab\u7ec6\u80de\u8c31\u6570\u636e\u5e93\uff0cImmunai\u5c06\u5176\u7eb3\u5165\u5176\u5e26\u6ce8\u91ca\u7684\u591a\u7ec4\u5b66\u514d\u75ab\u7ec6\u80de\u56fe\u96c6\uff08AMICA\uff09\u3002\u00a0Dropprint\u7684\u5458\u5de5\uff0c\u5305\u62ec\u8054\u5408\u521b\u59cb\u4ebaMeena Subramaniam\u548cRachel Gate\u5c06\u52a0\u5165Immunai\u7684\u673a\u5668\u5b66\u4e60\u548c\u8ba1\u7b97\u751f\u7269\u5b66\u56e2\u961f\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u4ec1\u4e1c\u533b\u5b66\u83b7\u5f97\u65b0\u4e00\u8f6e\u878d\u8d44\uff0c\u6295\u8d44\u65b9\u4e3a\u5bcc\u7422\u6295\u8d44<\/div>\n
2021\u5e743\u6708\u5e95\uff0c\u636e\u57fa\u56e0\u6167\u6d88\u606f\uff0c\u80bf\u7624\u7cbe\u51c6\u514d\u75ab\u8bca\u7597\u4f01\u4e1a\u4ec1\u4e1c\u533b\u5b66\u83b7\u5f97\u65b0\u4e00\u8f6e\u878d\u8d44\uff0c\u6295\u8d44\u65b9\u4e3a\u5bcc\u7422\u6295\u8d44\uff0c\u91d1\u989d\u672a\u62ab\u9732\u3002\u65e9\u57282018\u5e74\uff0c\u4ec1\u4e1c\u533b\u5b66\u5ba3\u5e03\u5b8c\u62107500\u4e07\u5143\u7684A\u8f6e\u878d\u8d44\uff0c\u7531\u901a\u548c\u6bd3\u627f\u9886\u6295\u3001\u62fe\u7389\u8d44\u672c\u5171\u540c\u53c2\u4e0e\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u542f\u51fd\u751f\u7269\u5b8c\u62106700\u4e07\u7f8e\u5143\u7684 A++ \u8f6e\u878d\u8d44<\/div>\n
2021\u5e743\u670829\u65e5\uff0c\u676d\u5dde\u542f\u51fd\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08\u7b80\u79f0\u201c\u542f\u51fd\u751f\u7269\u201d\uff09\u5b8c\u62106700\u4e07\u7f8e\u5143\u7684 A++ \u8f6e\u878d\u8d44\u3002\u672c\u8f6e\u878d\u8d44\u7531\u6218\u7565\u6295\u8d44\u65b9\u793c\u6765\u4e9a\u6d32\u57fa\u91d1\uff08Lilly Asia Ventures\uff09\u3001\u7ecf\u7eac\u4e2d\u56fd\u7b49\u53c2\u4e0e\uff0c\u7ea2\u6749\u8d44\u672c\u3001\u62db\u94f6\u56fd\u9645\u7b49\u8001\u80a1\u4e1c\u6301\u7eed\u52a0\u6301\u3002\u672c\u8f6e\u878d\u8d44\u8d44\u91d1\u5c06\u4e3b\u8981\u7528\u4e8e\u63a8\u8fdb\u542f\u51fd\u751f\u7269\u5728\u7ec6\u80de\u6cbb\u7597\u9886\u57df\u7684IND\u7814\u7a76\u548c\u4f4e\u514d\u75ab\u6027\u9879\u76ee\u4ee5\u53ca\u751f\u4ea7\u3002\u622a\u81f3\u76ee\u524d\uff0c\u542f\u51fd\u751f\u7269A\u8f6e\u7d2f\u8ba1\u878d\u8d44\u91d1\u989d\u5df2\u8d85\u8fc71\u4ebf\u7f8e\u5143\u3002<\/div>\n
\u00a0<\/div>\n
\u2756\u00a0\u5723\u7f8e\u751f\u7269\u5b8c\u62103\u4ebf\u5143B\u8f6e\u878d\u8d44\uff0c\u79f0\u5c06\u57282021\u5e74\u5b9e\u73b0\u9996\u4e2a\u80ba\u764c\u65e9\u8bca\u4ea7\u54c1\u5546\u4e1a\u5316<\/div>\n
2021\u5e744\u67082\u65e5\uff0c\u8d22\u7ecf\u7f51\u62a5\u9053\uff0c\u73e0\u6d77\u5723\u7f8e\u751f\u7269\u8bca\u65ad\u6280\u672f\u6709\u9650\u516c\u53f8\u5ba3\u5e03\u4e0eB\u8f6e\u878d\u8d44\u9886\u6295\u65b9\u56fd\u6295\u62db\u5546\u5b8c\u6210\u7b7e\u7ea6\uff0c\u56fd\u6295\u62db\u5546\u6295\u8d443\u4ebf\u5143\uff0c\u7528\u4e8e\u63a8\u52a8\u5723\u7f8e\u751f\u7269\u80ba\u764c\u65e9\u8bca\u6280\u672f\u7684\u5546\u4e1a\u5316\u8fdb\u7a0b\uff0c\u4ee5\u53ca\u5723\u7f8e\u751f\u7269\u5e03\u5c40\u591a\u764c\u79cd\u7684\u80bf\u7624\u6db2\u6001\u6d3b\u68c0\u76f8\u5173\u6280\u672f\u7684\u7814\u53d1\u3002\u4fe1\u606f\u663e\u793a\uff0c\u5723\u7f8e\u751f\u7269\u7531\u7f8e\u56fdCynvenio Biosystems Inc. \u4e0e\u4e3d\u73e0\u533b\u836f\u65d7\u4e0b\u5b50\u516c\u53f8\u73e0\u6d77\u4e3d\u73e0\u8bd5\u5242\u80a1\u4efd\u6709\u9650\u516c\u53f8\u4e8e2016\u5e743\u6708\u5171\u540c\u6295\u8d44\u521b\u7acb\uff0c\u5723\u7f8e\u751f\u7269\u603b\u7ecf\u7406\u77f3\u5251\u5cf0\u8868\u793a\uff0c2021\u5e74\uff0c\u5723\u7f8e\u751f\u7269\u5373\u5c06\u5b9e\u73b0\u9996\u4e2a\u80ba\u764c\u80bf\u7624\u65e9\u8bca\u4ea7\u54c1\u7684\u5546\u4e1a\u5316\u3002<\/div>\n
\u00a0<\/div>\n
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