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Biology\u671f\u520a\u7684\u6587\u7ae0\u7c7b\u578b\uff0c\u4e3a\u6295\u7a3f\u8005\u8bb2\u89e3\u4e86\u6295\u7a3f\u7684\u5468\u671f\u3001\u5ba1\u7a3f\u7684\u6d41\u7a0b\u7b49\u4fe1\u606f\u3002<\/div>\n<div>\u519b\u4e8b\u79d1\u5b66\u9662\u519b\u4e8b\u533b\u5b66\u7814\u7a76\u9662\u9648\u6cb3\u5175\u526f\u7814\u7a76\u5458\uff1a\u300a\u4ece\u4e09\u7ef4\u57fa\u56e0\u7ec4\u89c6\u89d2\u770b\u80bf\u7624\u7684\u53d1\u751f\u53d1\u5c55\u300b<\/div>\n<div>\u9648\u6cb3\u5175\u526f\u7814\u7a76\u5458\u57fa\u4e8eTAD\u5bfb\u627e\u9776\u6807\uff0c\u901a\u8fc7\u5bf9TAD\u8fb9\u754c\u6539\u53d8\u548c\u8f6c\u5f55\u5f02\u5e38\u7684\u7814\u7a76\u6765\u7b5b\u9009\u764c\u57fa\u56e0\u3002\u540c\u65f6\u7814\u7a76\u57fa\u56e0\u7ec4\u7ed3\u6784\u53d8\u5f02\u4e0e\u67d3\u8272\u8d28\u4e09\u7ef4\u7ed3\u6784\u6539\u53d8\u7684\u56e0\u679c\u5173\u7cfb\uff0c\u8fdb\u800c\u63a2\u7d22\u80f0\u817a\u764c\u53d1\u751f\u53d1\u5c55\u7684\u673a\u5236\u548c\u80bf\u7624\u7ec4\u7ec7\u4e2d\u5c42\u7ea7\u7ed3\u6784\u7684\u53d8\u5316\u3002<\/div>\n<div>\u5317\u4eac\u534f\u548c\u533b\u9662\u4efb\u535a\u535a\u58eb\uff1a\u300a\u80f0\u817a\u764c\u4fb5\u88ad\u8f6c\u79fb\u4e0e\u4e09\u7ef4\u57fa\u56e0\u7ec4\u300b\u00a0<\/div>\n<div>\u4efb\u535a\u535a\u58eb\u805a\u7126\u4e8e\u7814\u7a76\u8868\u89c2\u9057\u4f20\u5b66\u5728\u80f0\u817a\u764c\u4fb5\u88ad\u8f6c\u79fb\u4e2d\u7684\u5206\u5b50\u673a\u5236\u3002\u4efb\u535a\u535a\u58eb\u901a\u8fc7Hi-C\u6784\u5efa\u67d3\u8272\u8d28\u7684\u4e09\u7ef4\u7ed3\u6784\uff0c\u901a\u8fc7\u5404\u79cd\u7ec4\u86cb\u767d\u7684\u4fee\u9970\u548cChIP-seq\u7814\u7a76\u8868\u89c2\u7684\u8c03\u63a7\u5143\u4ef6\uff0c\u901a\u8fc7ATAC-seq\u7814\u7a76\u67d3\u8272\u8d28\u53ef\u53ca\u6027\uff0c\u901a\u8fc7RNA-seq\u68c0\u6d4b\u57fa\u56e0\u7684\u8868\u8fbe\uff0c\u7ee7\u800c\u5bfb\u627e\u80f0\u817a\u764c\u4fb5\u88ad\u8f6c\u79fb\u4e2d\u4e09\u7ef4\u57fa\u56e0\u7ec4\u6539\u53d8\u7684\u5173\u952e\u8fc7\u7a0b\u3002\u7ed3\u679c\u8868\u660e\uff0c\u80f0\u817a\u764c\u4fb5\u88ad\u8f6c\u79fb\u4e2d\u5b58\u5728\u591a\u7ef4\u5ea6\u7684\u4e09\u7ef4\u8868\u89c2\u57fa\u56e0\u7ec4\u91cd\u7f16\u7a0b\uff0c\u591a\u79cd\u8868\u89c2\u9057\u4f20\u91cd\u7f16\u7a0b\u673a\u5236\u534f\u540c\u4fc3\u8fdb\u80f0\u817a\u764c\u4fb5\u88ad\u8f6c\u79fb\u3002<\/div>\n<div>\u7f8e\u56fdUPMC\u533b\u5b66\u4e2d\u5fc3\u8d75\u6797\u6854\u535a\u58eb\uff1a\u300a\u80f6\u8d28\u7624\u80bf\u7624\u5fae\u73af\u5883\u548c\u514d\u75ab\u6cbb\u7597\u300b\u00a0<\/div>\n<div>\u8d75\u6797\u6854\u535a\u58eb\u7684\u7814\u7a76\u5bf9\u8c61\u662f\u81f4\u6b7b\u7387\u548c\u53d1\u75c5\u7387\u90fd\u5f88\u9ad8\u7684\u4e00\u79cd\u4e2d\u67a2\u795e\u7ecf\u5e38\u89c1\u80bf\u7624\u80f6\u8d28\u7624\uff0c\u5bf948\u4e2a\u75c5\u4eba\u6765\u6e90\u7684\u80bf\u7624\u5e72\u7ec6\u80de\u8fdb\u884cRNA-seq\u548cChIP-seq\u6d4b\u5e8f\uff0c\u9501\u5b9a\u4e86\u5bf9GSC\u7279\u5f02\u7684\u67d3\u8272\u8d28\u8c03\u63a7\u56e0\u5b50YY1\uff0c\u7814\u7a76\u7ed3\u679c\u8868\u660eYY1\u5728\u4f53\u5916\u53ef\u4ee5\u5f88\u597d\u5730\u6291\u5236\u80bf\u7624\u7684\u589e\u6b96\uff0c\u5728\u5c0f\u9f20\u4f53\u5185\u4e5f\u53ef\u4ee5\u51cf\u6162\u80bf\u7624\u7684\u751f\u957f\u901f\u5ea6\uff0c\u5ef6\u957f\u5c0f\u9f20\u7684\u751f\u5b58\u671f\u3002\u540c\u65f6\u8d75\u6797\u6854\u535a\u58eb\u4e5f\u7814\u7a76\u4e86\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\u5bf9\u80f6\u8d28\u7624\u7ec6\u80de\u8868\u578b\u7684\u5f71\u54cd\u3002<\/div>\n<div>\u5b89\u8bfa\u4f18\u8fbe\u674e\u534e\u4e91\u7ecf\u7406\uff1a\u300a\u8f6c\u5f55\u7ec4\u5728\u4e34\u5e8a\u533b\u5b66\u4e2d\u7684\u6df1\u5ea6\u5e94\u7528\u300b\u00a0<\/div>\n<div>\u674e\u534e\u4e91\u7ecf\u7406\u4ecb\u7ecd\u4e86\u5b89\u8bfa\u4f18\u8fbe\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\u7684\u4ea7\u54c1\u7c7b\u578b\u3002\u4ece\u8f6c\u5f55\u7ec4\u5728\u4eba\u7c7b\u75be\u75c5\u4e2d\u5e94\u7528\u7684\u6848\u4f8b\u6765\u89e3\u6790\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\u6280\u672f\u5728\u89e3\u6790\u8868\u8fbe\u8c31\uff0c\u9274\u5b9a\u878d\u5408\u57fa\u56e0\uff0c\u7814\u7a76\u53ef\u53d8\u526a\u5207\u548c\u7b49\u4f4d\u7279\u5f02\u8868\u8fbe\u7b49\u65b9\u9762\u7684\u5e94\u7528\uff0c\u5e2e\u52a9\u7814\u7a76\u8005\u4ece\u5168\u65b0\u7684\u89c6\u89d2\u5728\u4e34\u5e8a\u533b\u5b66\u4e2d\u5e94\u7528\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\u6280\u672f\u3002\u6700\u540e\u674e\u534e\u4e91\u7ecf\u7406\u4ecb\u7ecd\u4e86\u5b89\u8bfa\u4f18\u8fbe\u591a\u6837\u5316\u7684\u6d4b\u5e8f\u670d\u52a1\u5e73\u53f0\u3001\u201c\u5b89\u8bfa\u4e91\u201c\u5927\u6570\u636e\u5206\u6790\u5e73\u53f0\u3001\u533b\u5b66\u5927\u9879\u76ee\u56e2\u961f\u7b49\uff0c\u53ef\u4ee5\u4e3a\u5ba2\u6237\u63d0\u4f9b\u5177\u6709\u9ad8\u8d28\u91cf\u7684\u6d4b\u5e8f\u5206\u6790\u670d\u52a1\u3002<\/div>\n<div>PacBio \u516c\u53f8\u5e02\u573a\u526f\u603b\u76d1Jonathan Bibliowicz \u535a\u58eb\uff1a\u300aHiFi\u7cbe\u51c6\u957f\u8bfb\u957f\u6d4b\u5e8f\u4e0e\u66f4\u5b8c\u6574\u7684\u80bf\u7624\u57fa\u56e0\u7ec4\u5b66\u89e3\u51b3\u65b9\u6848\u300b<\/div>\n<div>\u00a0<\/div>\n<div>Jonathan Bibliowicz \u535a\u58eb\u4ecb\u7ecd\u4e86PacBio\u516c\u53f8\u7684HiFi\u957f\u8bfb\u957f\u6d4b\u5e8f\u7684\u7279\u70b9\uff0c\u8bfb\u957f\u53ef\u8fbe20kb\uff0c\u5177\u6709\u9ad8\u5e8f\u5217\u7cbe\u5ea6\u548c\u8986\u76d6\u5ea6\u3002Jonathan Bibliowicz\u4e5f\u4ecb\u7ecd\u4e86\u8fd9\u4e00\u6280\u672f\u5728\u764c\u75c7\u7814\u7a76\u4e2d\u7684\u5e94\u7528\uff0c\u4e0e\u77ed\u8bfb\u957f\u6d4b\u5e8f\u6bd4\u8f83\uff0c\u901a\u8fc7\u957f\u8bfb\u957f\u7684\u6d4b\u5e8f\u53ef\u4ee5\u9274\u5b9a\u51fa\u57fa\u56e0\u7684\u70b9\u7a81\u53d8\uff0c\u5f88\u597d\u5730\u9274\u5b9a\u51fa\u57fa\u56e0\u7ec4\u7684SVs\u3002\u901a\u8fc7\u5168\u957f\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\uff0c\u53ef\u4ee5\u63ed\u793a\u65b0\u7684\u57fa\u56e0\u878d\u5408\uff0c\u66f4\u597d\u5730\u89e3\u6790\u8f6c\u5f55\u6c34\u5e73\u53d1\u751f\u7684\u53ef\u53d8\u526a\u5207\uff0c\u53d1\u73b0\u66f4\u591a\u7684\u3001\u53ef\u4f5c\u4e3a\u764c\u75c7\u751f\u7269\u6807\u8bb0\u7269\u548c\u836f\u7269\u9776\u70b9\u7684\u5f02\u6784\u4f53\u3002<\/div>\n<div>\u56e0\u7f8e\u7eb3(Illumina)\u516c\u53f8\u8d44\u6df1\u5e94\u7528\u5e02\u573a\u7ecf\u7406\u5f6d\u95f1\u781a\uff1a\u300a\u5355\u7ec6\u80de\u591a\u7ec4\u5b66\uff1a\u591a\u7ef4\u5ea6\u5206\u6790\u6bcf\u4e00\u4e2a\u6837\u672c\u300b\u00a0<\/div>\n<div>\u5f6d\u95f1\u781a\u7ecf\u7406\u6839\u636e\u76ee\u524d\u7684\u7814\u7a76\u70ed\u70b9\u4e3a\u7814\u7a76\u8005\u603b\u7ed3\u4e86\u76ee\u524d\u56fd\u5185\u5916\u7814\u7a76\u4e2d\u5e38\u89c1\u7684\u5355\u7ec6\u80de\u591a\u7ec4\u5b66\u7684\u65b9\u6cd5\uff0c\u9996\u5148\u662f\u5e94\u7528\u5355\u7ec6\u80de\u8868\u89c2\u9057\u4f20\u548c\u8f6c\u5f55\u7ec4\uff08scATAC-seq\u548cmRNA-seq\uff09\uff0c\u5176\u6b21\u662f\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u548c\u86cb\u767d\u8d28\u7ec4\uff08CITE-seq\uff09\u7684\u8054\u7528\u3002\u6700\u540e\u662f\u5355\u7ec6\u80de\u57fa\u56e0\u7ec4\u548c\u86cb\u767d\u8d28\u7ec4\u8054\u7528\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u56e0\u7f8e\u7eb3\u516c\u53f8\u5728\u4ee5\u4e0a\u4ecb\u7ecd\u7684\u591a\u79cd\u65b9\u6848\u7684\u591a\u7ec4\u5b66\u7814\u7a76\u4e2d\uff0c\u90fd\u6709\u76f8\u5e94\u7684\u914d\u5957\u5e73\u53f0\u548c\u89e3\u51b3\u65b9\u6848\u3002<\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgC20IAWYYQHib5icicO7oTVia7hQUV7XN4REwccmNrF2gLLkoQgyO9E6Etv3DDyzhHPbImwDHfhRq6m1w.png\" alt=\"RmFicvQBAkgC20IAWYYQHib5icicO7oTVia7hQUV7XN4REwccmNrF2gLLkoQgyO9E6Etv3DDyzhHPbImwDHfhRq6m1w\"\/><\/figure><\/div>\n\n<p style=\"text-align: center;\">\u56fe\uff1a\u4f1a\u8bae\u73b0\u573a<\/p>\n<div>\u4e09. 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href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247511293&amp;idx=1&amp;sn=3d51b2a2ed0bd00d25d259cf583a9d96&amp;chksm=eb711e4adc06975c39072488c527af018071a7c7ba83e37052b956c08dd35a915cc3b10c01ae&amp;scene=21#wechat_redirect\">New Phytol\uff1a\u835e\u9ea6\u57fa\u56e0\u7ec4\u7684\u6bd4\u8f83\u5206\u6790<\/a><\/div>\n<div><a 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