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\u300a2023\u57fa\u56e0\u884c\u4e1a\u84dd\u76ae\u4e66\u300b\u8bda\u9080\u5408\u4f5c\u00a0<\/p>\n<p>\u5df2\u5408\u4f5c\uff1a\u7f57\u6c0f\u8bca\u65ad\u3001\u5b57\u8282\u8df3\u52a8\u3001\u661f\u4e91\u57fa\u56e0\u2026\u2026<\/p>\n<p>\u8054\u7cfb\u65b9\u5f0f\uff1alily@genonet.cn<\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/RmFicvQBAkgBLLQulNFU0icHW9v9szP7b7RwRbpBl3wSzic4ibeWV8AbiaG0P37O4IklZQAsbgG8X0ib1AekKKwwov4g\/0?wx_fmt=jpeg\" alt=\"0?wx_fmt=jpeg\"\/><\/figure><\/div>\n\n<div><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247512551&amp;idx=1&amp;sn=c85f663051563e930d706360d5f2408b&amp;chksm=eb710350dc068a46711605a979ec7f399ad86f8a1e6c1899e32ec0a031badd801f44b1c49b8b&amp;scene=21#wechat_redirect\">\u300a2022\u57fa\u56e0\u884c\u4e1a\u84dd\u76ae\u4e66\u300b\u53d1\u5e03\u4f1a<\/a><\/div>\n<div><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247505484&amp;idx=1&amp;sn=59bad9d975bc2b3d14a2cc7d3fcca757&amp;chksm=eb7164fbdc06eded4d62f7a4660af0e0e5f78b8bbb7a5bee78e8fc4fe5c599d39c3669040e1c&amp;scene=21#wechat_redirect\">\u300a\u80bf\u7624\u57fa\u56e0\u53ca\u5206\u5b50\u68c0\u6d4b\u84dd\u76ae\u4e66\u300b\u53d1\u5e03\u4f1a<\/a><\/div>\n<div><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247500152&amp;idx=1&amp;sn=cb0d0456356751e8238f8c909caef357&amp;chksm=eb7173cfdc06fad91673b17999836ea987d2e0ecd266adbacd229dfb35d476727c35891586f0&amp;scene=21#wechat_redirect\">\u300a\u57fa\u56e0\u5927\u6570\u636e\u884c\u7814\u62a5\u544a\u300b\u53d1\u5e03\u4f1a<\/a><\/div>\n<p style=\"text-align: center;\">\u65b0\u4ea7\u54c1<\/p>\n<div>\u2756\u00a0\u56fd\u5bb6\u836f\u76d1\u5c401\u6708\u5171\u6279\u51c6\u6ce8\u518c\u533b\u7597\u5668\u68b0\u4ea7\u54c1124\u4e2a<\/div>\n<div>\u6839\u636e\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u5b98\u7f51\uff0c2023\u5e741\u6708\uff0c\u56fd\u5bb6\u836f\u76d1\u5c40\u5171\u6279\u51c6\u6ce8\u518c\u533b\u7597\u5668\u68b0\u4ea7\u54c1124\u4e2a\u3002\u5176\u4e2d\uff0c\u5883\u5185\u7b2c\u4e09\u7c7b\u533b\u7597\u5668\u68b0\u4ea7\u54c199\u4e2a\uff0c\u8fdb\u53e3\u7b2c\u4e09\u7c7b\u533b\u7597\u5668\u68b0\u4ea7\u54c111\u4e2a\uff0c\u8fdb\u53e3\u7b2c\u4e8c\u7c7b\u533b\u7597\u5668\u68b0\u4ea7\u54c112\u4e2a\uff0c\u6e2f\u6fb3\u53f0\u533b\u7597\u5668\u68b0\u4ea7\u54c12\u4e2a\u3002<\/div>\n<div>\u5176\u4e2d\uff0c\u57fa\u56e0\u6167\u68b3\u7406\u83b7\u6279\u7684\u57fa\u56e0\u79d1\u6280\u76f8\u5173\u7684\u4ea7\u54c1\u5982\u4e0b\uff1a<\/div>\n<p>\u5e8f\u53f7\u4ea7\u54c1\u540d\u79f0\u6ce8\u518c\u4eba\u540d\u79f0\u6ce8\u518c\u8bc1\u7f16\u53f71\u4eba\u7c7bEGFR\u57fa\u56e0\u7a81\u53d8\u68c0\u6d4b\u8bd5\u5242\u76d2\uff08\u8367\u5149PCR\u6cd5\uff09\u5609\u5174\u5141\u82f1\u533b\u5b66\u68c0\u9a8c\u6709\u9650\u516c\u53f8\u56fd\u68b0\u6ce8\u51c6202334000092\u200d\u4e8c\u5341\u9879\u9057\u4f20\u6027\u8033\u804b\u57fa\u56e0\u7a81\u53d8\u68c0\u6d4b\u8bd5\u5242\u76d2\uff08\u98de\u884c\u65f6\u95f4\u8d28\u8c31\u6cd5\uff09\u5e7f\u5dde\u5e02\u8fbe\u745e\u751f\u7269\u6280\u672f\u80a1\u4efd\u6709\u9650\u516c\u53f8\u56fd\u68b0\u6ce8\u51c6202334000123\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\uff082019-nCoV\uff09\u3001\u7532\u578b\u6d41\u611f\u75c5\u6bd2\u548c\u4e59\u578b\u6d41\u611f\u75c5\u6bd2\u6838\u9178\u68c0\u6d4b\u8bd5\u5242\u76d2\uff08\u8367\u5149PCR\u6cd5\uff09\u82cf\u5dde\u521b\u6f9c\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\u56fd\u68b0\u6ce8\u51c6202334000904\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2(2019-nCoV)\u6838\u9178\u68c0\u6d4b\u8bd5\u5242\u76d2(\u8367\u5149PCR\u6cd5)\u82cf\u5dde\u5929\u9686\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\u56fd\u68b0\u6ce8\u51c6202334000915\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\uff082019-nCoV\uff09\u6297\u539f\u68c0\u6d4b\u8bd5\u5242\u76d2\uff08\u80f6\u4f53\u91d1\u6cd5\uff09\u5723\u6e58\u751f\u7269\u79d1\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8\u56fd\u68b0\u6ce8\u51c6202334000926\u5b9e\u65f6\u8367\u5149\u5b9a\u91cfPCR\u5206\u6790\u4eea\u5317\u4eac\u81f4\u96e8\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\u56fd\u68b0\u6ce8\u51c620233220093<\/p>\n<div>\u6587\u4ef6\u4e0b\u8f7d\u516c\u5f00\u5730\u5740&gt;&gt;https:\/\/www.nmpa.gov.cn\/directory\/web\/nmpa\/images\/1676252836874075545.docx<\/div>\n<div>\u00a0<\/div>\n<div>\u2756\u00a0\u6700\u5168\u7f55\u89c1\u75c5\u77e5\u8bc6\u6570\u636e\u5e93Orphanet\u5b98\u65b9\u4e2d\u6587\u7248\u4e0a\u7ebf<\/div>\n<div>2023\u5e742\u670824\u65e5\uff0c\u6839\u636e\u4e2d\u56fd\u7f55\u89c1\u75c5\u8054\u76df\u5b98\u65b9\u6d88\u606f\uff0cOrphanet\u4e2d\u6587\u7248\u5728\u4e2d\u56fd\u7f55\u89c1\u75c5\u8054\u76df\u5b98\u65b9\u4e91\u5e73\u53f0\u4e0a\u7ebf\uff0c\u4e2d\u56fd\u7f55\u89c1\u75c5\u8054\u76df\u8054\u5408\u5317\u4eac\u534f\u548c\u533b\u9662\u3001\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u513f\u79d1\u533b\u9662\u7684\u4e13\u5bb6\u5171\u540c\u5bf9\u8be5\u6570\u636e\u5e93\u8fdb\u884c\u4e86\u4e2d\u6587\u7ffb\u8bd1\u548c\u6821\u5bf9\uff0c\u4e3a\u4e86\u4fbf\u4e8e\u6211\u56fd\u533b\u7597\u4e13\u4e1a\u4eba\u5458\u548c\u7814\u7a76\u4eba\u5458\u5bf9\u7f55\u89c1\u75c5\u6709\u5173\u7684\u81f4\u75c5\u57fa\u56e0\u3001\u6d41\u884c\u75c5\u5b66\u3001\u8bca\u65ad\u3001\u6cbb\u7597\u836f\u7269\u3001\u4e34\u5e8a\u9879\u76ee\u548c\u7814\u7a76\u4fe1\u606f\u8fdb\u884c\u4e86\u89e3\u548c\u83b7\u53d6\uff0c\u73b0\u9762\u5411\u5168\u7403\u7684\u4e34\u5e8a\u533b\u751f\u514d\u8d39\u5f00\u653e\u3002<\/div>\n<div>\u53c2\u8003\u4fe1\u606f\u53ca\u6570\u636e\u5e93\u5165\u53e3&gt;&gt;https:\/\/mp.weixin.qq.com\/s\/7F_DYsFPmURfyVrbOAmzDw<\/div>\n<div>\u00a0<\/div>\n<div>\u2756\u00a0\u8fc7\u53bb\u56db\u5e74\uff0c\u7f8e\u56fd\u548c\u6b27\u76df\u5171\u6279\u51c6\u4e86180\u79cd\u751f\u7269\u5236\u836f\u4ea7\u54c1<\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCv7wWMgh0SpAIn6syfrx74OrVchhG8oMOotwReRnt8K3G76xk19yym2eR39fkFnyANukakQiapqwg.png\" alt=\"RmFicvQBAkgCv7wWMgh0SpAIn6syfrx74OrVchhG8oMOotwReRnt8K3G76xk19yym2eR39fkFnyANukakQiapqwg\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe\uff1a\u751f\u7269\u836f\u83b7\u6279\u4ea7\u54c1\u6570\u91cf\u8d8b\u52bf<\/div>\n<div style=\"text-align: center;\">\uff08\u6765\u6e90\/Nature Biotechnology\uff09<\/div>\n<div>\u6839\u636eNature Biotechnology\u62a5\u9053\uff0c2018\u5e741\u6708\u81f32022\u5e746\u6708\uff0c\u7f8e\u56fd\u548c\u6b27\u76df\u6279\u51c6\u4e86197\u79cd\u751f\u7269\u5236\u836f\u4ea7\u54c1\uff0c\u8003\u8651\u4e00\u4e9b\u4ea7\u54c1\u542b\u6709\u76f8\u540c\u7684\u6d3b\u6027\u6210\u5206\u6216\u5728\u4e0d\u540c\u5730\u533a\u4ee5\u4e0d\u540c\u7684\u5546\u54c1\u540d\u79f0\u9500\u552e\uff0c\u5373180\u79cd\u3002<\/div>\n<div>\u5176\u4e2d\uff0c\u83b7\u6279\u7684\u6838\u9178\u836f\u7269\u4ea7\u54c1\u5305\u62ec12\u79cd\uff0c\u53735\u79cd\u5c0f\u5e72\u6270RNA (siRNA)\u836f\u7269(Amvuttra, Leqvio, Givlaari, Oxlumo\u548cOnpattro)\uff0c5\u79cd\u53cd\u4e49\u6838\u9178\u836f\u7269(Amondys 45, Viltepso, Viondys 53, Waylivra\u548cTegsedi)\u548c2\u79cd\u57fa\u56e0\u6cbb\u7597\u836f\u7269(Zolgensma\u548cLuxturna)\uff0c\u51e0\u4e4e\u90fd\u662f\u5b64\u513f\u836f\u3002<\/div>\n<div>\u83b7\u6279\u7684\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u51719\u79cd\uff08\u4e0a\u4e00\u4e2a\u56db\u5e74\u53ea\u6279\u51c62\u4e2a\uff09\uff0c\u5176\u4e2d6\u79cd\u4ea7\u54c1\u662f\u57fa\u4e8eCAR-T\u7ec6\u80de\uff0c\u7528\u4e8e\u6cbb\u7597\u8840\u6e90\u6027\u6076\u6027\u80bf\u7624(\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff0c\u767d\u8840\u75c5\uff0c\u7279\u522b\u662f\u6dcb\u5df4\u7624)\u3002CAR-T\u4ea7\u54c1\u6cbb\u7597\u4ef7\u683c\u901a\u5e38\u572840\u4e07\u81f350\u4e07\u7f8e\u5143\u4e4b\u95f4\u3002<\/div>\n<div>\u6839\u636ePhRMA\u516c\u5e03\u7684\u6570\u636e\uff0c\u76ee\u524d\u5168\u7403\u6709\u8d85\u8fc77800\u79cd\u751f\u7269\u836f\u7269\u4ea7\u54c1\u5904\u4e8e\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\uff0c\u5176\u4e2d\u8d85\u8fc71000\u79cd\u5df2\u8fdb\u5165III\u671f\u8bd5\u9a8c\uff0c\u8fd11\/3\u7684\u4e34\u5e8a\u5f00\u53d1\u4ea7\u54c1(2533\u79cd)\u662f\u57fa\u4e8e\u5355\u6297\u7684\uff1b\u76ee\u524d\u6b63\u5728\u4e34\u5e8a\u8bc4\u4f30\u7684\u57fa\u56e0\u4fee\u9970\u7684\u7ec6\u80de\u7597\u6cd5\u4e3a348\u79cd\uff0c\u6838\u9178\u548c\u57fa\u56e0\u7597\u6cd5\u4e3a546\u79cd\u3002\u764c\u75c7\u4ecd\u7136\u662f\u6700\u5e38\u89c1\u7684\u5355\u4e00\u9002\u5e94\u75c7\uff0c\u5176\u4ed6\u5e38\u89c1\u7684\u76ee\u6807\u9002\u5e94\u75c7\u5305\u62ec\u9057\u4f20\u75be\u75c5\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u4ee5\u53ca\u795e\u7ecf\u7cfb\u7edf\u3001\u773c\u775b\u548c\u8840\u6db2\u75be\u75c5\u3002<\/div>\n<div>\u6587\u7ae0PDF\u4e0b\u8f7d\u5730\u5740&gt;&gt;<\/div>\n<div>https:\/\/www.nature.com\/articles\/s41587-022-01582-x.pdf<\/div>\n<p style=\"text-align: center;\">\u5927\u4f01\u4e1a<\/p>\n<div>\u2756\u00a0\u7f57\u6c0f\u96c6\u56e2\u4e0e\u73e0\u6d77\u5e02\u4eba\u6c11\u533b\u9662\u533b\u7597\u96c6\u56e2\u7b7e\u7f72\u6218\u7565\u5408\u4f5c\u534f\u8bae<\/div>\n<div>2023\u5e742\u670820\u65e5\uff0c\u7f57\u6c0f\u96c6\u56e2\u4e0e\u73e0\u6d77\u5e02\u4eba\u6c11\u533b\u9662\u533b\u7597\u96c6\u56e2\u6b63\u5f0f\u7b7e\u7f72\u6218\u7565\u5408\u4f5c\u534f\u8bae\u3002\u5171\u540c\u63a2\u7d22\u809d\u764c\u5168\u75c5\u7a0b\u7ba1\u7406\u4f53\u7cfb\u5efa\u8bbe\uff0c\u63a8\u52a8\u7cbe\u51c6\u533b\u5b66\u8bca\u65ad\u89e3\u51b3\u65b9\u6848\u7684\u642d\u5efa\u4e0e\u8fed\u4ee3\uff0c\u52a0\u5f3a\u9ad8\u8d28\u91cf\u5b66\u79d1\u5efa\u8bbe\u53ca\u533b\u9662\u7cbe\u7ec6\u5316\u7ba1\u7406\uff0c\u4e3a\u5168\u9762\u63d0\u9ad8\u73e0\u6d77\u533b\u7597\u5065\u5eb7\u670d\u52a1\u6c34\u5e73\u8d21\u732e\u529b\u91cf\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u53c2\u8003\u4fe1\u606f&gt;&gt;https:\/\/mp.weixin.qq.com\/s\/6rFlTlp7uq3HyasV_pD4iQ<\/div>\n<p style=\"text-align: center;\">\u597d\u4f1a\u8bae<\/p>\n<div>\u27562022\u4e2d\u56fd\u80bf\u7624\u6807\u5fd7\u7269\u5b66\u672f\u5927\u4f1a\uff0c\u4e0a\u6d77\uff0c2023\u5e744\u67087\u65e5-9\u65e5<\/div>\n<div>\u7531\u4e2d\u56fd\u6297\u764c\u534f\u4f1a\u80bf\u7624\u6807\u5fd7\u4e13\u4e1a\u59d4\u5458\u4f1a\u4e3b\u529e\u76842022\u5e74\u4e2d\u56fd\u80bf\u7624\u6807\u5fd7\u7269\u5b66\u672f\u5927\u4f1a\u66a8\u4e2d\u56fd\u6574\u5408\u80bf\u7624\u5b66\u5927\u4f1a\u66a8\u7b2c\u5341\u516d\u5c4a\u80bf\u7624\u6807\u5fd7\u7269\u9752\u5e74\u79d1\u5b66\u5bb6\u8bba\u575b\u66a8\u4e2d\u56fd\u80bf\u7624\u6807\u5fd7\u7269\u4ea7\u4e1a\u521b\u65b0\u5927\u4f1a\uff0c\u5c06\u4e8e2023\u5e744\u67087\u65e5-9\u65e5\u4ee5\u56db\u4f1a\u8054\u529e\u7684\u5f62\u5f0f\u5728\u4e0a\u6d77\u9686\u91cd\u53ec\u5f00\u3002<\/div>\n<p>\u53c2\u8003\u4fe1\u606f&gt;&gt;<a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzI3MDYwODc4NA==&amp;mid=2247552814&amp;idx=1&amp;sn=63e105a88d40a4cb080e701e81f94c1d&amp;scene=21#wechat_redirect\">https:\/\/mp.weixin.qq.com\/s\/UQtzmY5Vla4yquweknahbQ<\/a><\/p>\n<p>&nbsp;<\/p>\n<div>\u2756\u56fd\u9645\u57fa\u56e0\u7ec4\u5b66\u5927\u4f1a\u7b2c18\u5c4a\u5e74\u4f1a\uff0c\u4e2d\u56fd\/\u65b0\u52a0\u5761\/\u82f1\u56fd\uff0c2023\u5e744\u670812~27\u65e5<\/div>\n<div>\u56fd\u9645\u57fa\u56e0\u7ec4\u5b66\u5927\u4f1a\u7b2c18\u5c4a\u5e74\u4f1a\uff08ICG-18\uff09\u521d\u6b65\u5b9a\u4e8e2023\u5e744\u670812\u65e5\u81f327\u65e5\u5728\u4e2d\u56fd\u7684\u591a\u4e2a\u57ce\u5e02\uff08\u5f20\u5bb6\u754c\u3001\u5317\u4eac\u3001\u4e0a\u6d77\u3001\u6e29\u5dde\u3001\u897f\u5b89\u3001\u91cd\u5e86\u3001\u6b66\u6c49\u3001\u676d\u5dde\u7b49\u5730\uff09\u4ee5\u53ca\u65b0\u52a0\u5761\u548c\u82f1\u56fd\u4f26\u6566\u4e3e\u884c\u3002<\/div>\n<div>ICG-18\u5c06\u4e00\u8d77\u56de\u987e\u5e76\u5e86\u795d\u751f\u547d\u79d1\u5b66\u53d1\u5c55\u53f2\u4e0a\u7684\u4f17\u591a\u9ad8\u5149\u65f6\u523b\uff1aHGP\u5b8c\u621020\u5468\u5e74\u3001DNA\u201c\u53cc\u87ba\u65cb\u201d\u7ed3\u6784\u53d1\u73b070\u5468\u5e74\u3001\u201cWHAT IS 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