{"id":7989,"date":"2023-03-09T08:00:00","date_gmt":"2023-03-09T00:00:00","guid":{"rendered":"https:\/\/www.geneclub.net.cn\/index.php\/2023\/03\/09\/534854\/"},"modified":"2026-04-07T16:53:33","modified_gmt":"2026-04-07T08:53:33","slug":"534854","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2023\/03\/09\/534854\/","title":{"rendered":"\u201c\u6570\u5b57\u4e2d\u56fd\u201d\u7684\u521b\u65b0\u9ad8\u5730\uff1a\u6570\u5b57\u751f\u547d\u5065\u5eb7\u2014\u2014\u57fa\u56e0\u4ea7\u4e1a\u9ad8\u8d28\u91cf\u53d1\u5c55\u601d\u8003\uff08\u4e8c\uff09"},"content":{"rendered":"<p><!-- wechat_content_hash: 506fe5e94f904929 --><\/p>\n<p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBJ4sibF985CB53GqXpdUXJY1ibXic4tk7cicKMPtgyMRqWYUopq6yOghicWK3LOe3qL8V3Rjia4kHVKgsA.jpeg\" alt=\"RmFicvQBAkgBJ4sibF985CB53GqXpdUXJY1ibXic4tk7cicKMPtgyMRqWYUopq6yOghicWK3LOe3qL8V3Rjia4kHVKgsA\"\/><\/figure><\/div>\n\n<p>2023\u5e742\u670827\u65e5\uff0c\u4e2d\u5171\u4e2d\u592e\u56fd\u52a1\u9662\u53d1\u5e03\u300a\u6570\u5b57\u4e2d\u56fd\u5efa\u8bbe\u6574\u4f53\u5e03\u5c40\u89c4\u5212\u300b\uff0c\u9996\u6b21\u5c06\u6570\u5b57\u4e2d\u56fd\u5efa\u8bbe\u5217\u5165\u5e72\u90e8\u8003\u6838\u8bc4\u4ef7\u7684\u53c2\u8003\u3002\u9664\u4e86\u57fa\u7840\u8bbe\u65bd\uff0c\u201c\u6570\u5b57\u4e2d\u56fd\u201d\u521b\u65b0\u9ad8\u5730\u662f\u6570\u5b57\u751f\u547d\u5065\u5eb7\uff0c\u8fd9\u4e5f\u662f\u57fa\u56e0\u4ea7\u4e1a\u9ad8\u8d28\u91cf\u53d1\u5c55\u7684\u5916\u5ef6\u3002\u5b83\u7684\u5185\u6db5\u662f\u4ec0\u4e48\uff0c\u5982\u4f55\u8d4b\u80fd\u57fa\u7840\u7814\u7a76\u3001\u4ea7\u4e1a\u878d\u5408\u4ee5\u53ca\u533a\u57df\u53d1\u5c55\uff1f\u57fa\u56e0\u6167\u63a2\u8ba8\u5982\u4e0b\uff0c\u66f4\u591a\u8be6\u60c5\u548c\u8c03\u7814\u6570\u636e\u5c06\u6536\u5f55\u5230\u8fde\u7eed\u7b2c\u516d\u5e74\u53d1\u5e03\u7684\u300a2023\u57fa\u56e0\u884c\u4e1a\u84dd\u76ae\u4e66\u300b\uff0c\u6b22\u8fce\u53c2\u4e0e\u8054\u5408\u53d1\u5e03\u5408\u4f5c\u3002<\/p>\n<p>\u4e00\u3001\u4ece\u6570\u5b57\u4e2d\u56fd\u5230\u6570\u5b57\u751f\u547d\u5065\u5eb7<\/p>\n<div>\u4ece\u79d1\u6280\u53ca\u4ea7\u4e1a\u89d2\u5ea6\uff0c\u300a\u6570\u5b57\u4e2d\u56fd\u5efa\u8bbe\u6574\u4f53\u5e03\u5c40\u89c4\u5212\u300b\uff08\u4ee5\u4e0b\u7b80\u79f0\u201c\u89c4\u5212\u201d\uff09\u63d0\u51fa\u4e24\u5927\u91cd\u70b9\u3002<\/div>\n<p>\u4e00\u662f\u201c\u4e24\u5927\u57fa\u7840\u201d\uff1a\u6570\u5b57\u57fa\u7840\u8bbe\u65bd\u548c\u6570\u636e\u8d44\u6e90\u4f53\u7cfb\uff0c\u5176\u672c\u8d28\u662f\u201c\u7b97\u529b\u201d\u2014\u2014\u5e7f\u4e49\u7684\u7b97\u529b\u6307\u5bf9\u6570\u5b57\u5316\u4fe1\u606f\u5904\u7406\u80fd\u529b\uff0c\u5305\u62ec\u7f51\u7edc\u3001\u5b58\u50a8\u3001\u8ba1\u7b97\u3001\u6570\u636e\u6316\u6398\u53ca\u5408\u89c4\u5171\u4eab\u7b49\uff0c\u4e0e\u4e4b\u5bf9\u5e94\u7684\u5206\u522b\u662f\u89c4\u5212\u4e2d\u63d0\u53ca\u7684\u57fa\u7840\u5efa\u8bbe\u76ee\u6807\uff1aIPv6\/\u5317\u6597\u3001\u6570\u636e\u4e2d\u5fc3\u3001\u667a\u80fd\u8ba1\u7b97\u4e2d\u5fc3\u3001\u56fd\u5bb6\u6570\u636e\u8d44\u6e90\u5e93\u7b49\u3002<\/p>\n<p>\u4e8c\u662f\u6570\u5b57\u7ecf\u6d4e\uff0c\u5373\u6570\u5b57\u6280\u672f\u548c\u5b9e\u4f53\u7ecf\u6d4e\u7684\u878d\u5408\uff0c\u5373\u6570\u5b57\u6280\u672f\u7684\u8d4b\u80fd\u4ef7\u503c\uff0c\u7279\u522b\u662f\u4e0e\u519c\u4e1a\u3001\u5de5\u4e1a\u3001\u91d1\u878d\u3001\u6559\u80b2\u3001\u533b\u7597\u3001\u4ea4\u901a\u3001\u80fd\u6e90\u7b49\u7ecf\u6d4e\u7684\u878d\u5408\u3002<\/p>\n<p>\u9664\u4e86\u65e9\u671f\u7684\u57fa\u7840\u8bbe\u65bd\u5efa\u8bbe\uff0c\u4ece\u957f\u8fdc\u7684\u5e94\u7528\u53ca\u5e02\u573a\u4ef7\u503c\u4e0a\uff0c\u5934\u53f7\u521b\u65b0\u9ad8\u5730\u662f\u6570\u5b57\u751f\u547d\u5065\u5eb7\uff0c\u5373\u201cBT+IT+DT\u201d\u3002\u5177\u4f53\u5730\uff0c\u4ee5\u9ad8\u901a\u91cf\u6d4b\u5e8f\u3001\u5355\u7ec6\u80de\u3001\u7a7a\u95f4\u7ec4\u5b66\u3001\u86cb\u767d\u7ec4\u5b66\u4e3a\u4ee3\u8868\u7684\u524d\u6cbf\u751f\u547d\u7ec4\u5b66\u6280\u672f\u548c\u4fe1\u606f\u6280\u672f\u3001\u6570\u5b57\u6280\u672f\u7ed3\u5408\uff0c\u4e0e\u533b\u7597\u3001\u5065\u5eb7\u3001\u519c\u4e1a\u3001\u751f\u6001\u7b49\u573a\u666f\u6df1\u5ea6\u878d\u5408\uff0c\u6784\u5efa\u6570\u5b57\u751f\u547d\u5065\u5eb7\uff0c\u901a\u8fc7\u6570\u636e\u8d44\u6e90\u5e93\u548c\u6570\u5b57\u4ea7\u4e1a\u96c6\u7fa4\uff0c\u8d4b\u80fd\u7ecf\u6d4e\u548c\u6c11\u751f\u7684\u9ad8\u8d28\u91cf\u53d1\u5c55\u3002<\/p>\n<p>\u5176\u4e2d\uff0c\u4ee5\u57fa\u56e0\u7ec4\u4e3a\u4ee3\u8868\u7684\u751f\u547d\u591a\u7ec4\u5b66\uff0c\u672c\u8d28\u662f\u5c06\u751f\u547d\u5065\u5eb7\u6570\u5b57\u5316\uff0c\u6784\u5efaEB\u7ea7\u522b\u7684\u751f\u547d\u7ec4\u5b66\u5927\u6570\u636e\uff0c\u4ee3\u8868\u673a\u6784\u662f\u56e0\u7f8e\u7eb3\u3001\u534e\u5927\u3001\u725b\u6d25\u7eb3\u7c73\u5b54\u7b49\uff0c\u901a\u8fc7\u751f\u547d\u7ec4\u5b66\u5927\u6570\u636e\u7ed8\u5236\u4e2a\u4f53\u3001\u5bb6\u5ead\u53ca\u7fa4\u4f53\u7684\u751f\u547d\u6570\u5b57\u5316\u56fe\u8c31\uff1b\u540c\u65f6\u8fd9\u79bb\u4e0d\u5f00\u4e0e\u6570\u5b57\u6280\u672f\u7d27\u5bc6\u878d\u5408\u53ca\u4ea7\u4e1a\u534f\u4f5c\uff0c\u5145\u5206\u6316\u6398\u6570\u636e\u4fe1\u606f\u5e76\u63d0\u5347\u7b97\u529b\uff0c\u4ee3\u8868\u673a\u6784\u662f\u8c37\u6b4c\u3001\u4e9a\u9a6c\u900a\u4e91\u3001\u534e\u4e3a\u3001\u963f\u91cc\u4e91\u7b49\u3002<\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCqeia7gvOdXU6g1GtzX6jmOnA0JICfv4FLg4h0bu1HGXDOZT6faGFYiaN9EPOUIwue5BzSjAtBDiaRA.png\" alt=\"RmFicvQBAkgCqeia7gvOdXU6g1GtzX6jmOnA0JICfv4FLg4h0bu1HGXDOZT6faGFYiaN9EPOUIwue5BzSjAtBDiaRA\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u8868\uff1a\u4e2d\u7f8e\u524d50\u764c\u75c7\u7684\u57fa\u56e0\u56fe\u8c31<\/div>\n<div style=\"text-align: center;\">\u6765\u6e90\/Nat Commun. 2022; 13: 5651.<\/div>\n<p>\u751f\u547d\u7ec4\u5b66\u6280\u672f\u4e0e\u6570\u5b57\u6280\u672f\u7684\u878d\u5408\u662f\u201c\u53cc\u5411\u5954\u8d74\u201d\u7684\uff0c\u5171\u540c\u6784\u5efa\u6570\u5b57\u751f\u547d\u5065\u5eb7\u7684\u6570\u636e\u8d44\u6e90\u5e93\u548c\u7b97\u529b\u7b49\u57fa\u7840\u8bbe\u65bd\uff1a<\/p>\n<p>\u4e00\u65b9\u9762\uff0c\u9664\u4e86\u7535\u529b\u3001\u7164\u77ff\u3001\u822a\u7a7a\u822a\u5929\u3001\u6df1\u6d77\u7b49\u573a\u666f\uff0c\u533b\u7597\u5065\u5eb7\u9886\u57df\u662f\u6570\u5b57\u6280\u672f\u5e73\u53f0\u7684\u6700\u5177\u89c4\u6a21\u548c\u524d\u666f\u7684\u5e94\u7528\u573a\u666f\uff0c\u4e14\u4e0e\u751f\u547d\u7ec4\u5b66\u5927\u6570\u636e\u6709\u6781\u5f3a\u8026\u5408\u6027\u548c\u6570\u636e\u6574\u5408\u7a7a\u95f4\uff0c\u5c06\u5b9e\u73b0\u6570\u5b57\u6280\u672f\u7684\u5e02\u573a\u4ef7\u503c\uff0c\u5e76\u8bad\u7ec3\u5e73\u53f0\u7684\u6269\u5c55\u6027\u548c\u5b9e\u7528\u6027\u3002<\/p>\n<p>\u53e6\u4e00\u65b9\u9762\uff0c\u751f\u547d\u7ec4\u5b66\u9700\u8981\u6570\u5b57\u6280\u672f\u7684\u7b97\u529b\u548c\u6570\u636e\u6316\u6398\u80fd\u529b\uff0c\u6765\u8fdb\u884c\u5927\u89c4\u6a21\u6570\u636e\u7684\u5b58\u50a8\uff0c\u7f29\u77ed\u6570\u636e\u8ba1\u7b97\u548c\u5206\u6790\u7684\u5468\u671f\uff0c\u8fdb\u4e00\u6b65\u6316\u6398\u6570\u636e\u7684\u4fe1\u606f\u548c\u4ef7\u503c\uff0c\u5efa\u8bbe\u6570\u636e\u5e73\u53f0\u3001\u4fe1\u606f\u7ba1\u7406\u7cfb\u7edf\u548c\u5927\u6570\u636e\u4e2d\u5fc3\u3002<\/p>\n<p>\u4e8c\u3001\u6570\u5b57\u751f\u547d\u5065\u5eb7\u7684\u5185\u6db5\u63a2\u8ba8<\/p>\n<p>\u6570\u5b57\u751f\u547d\u5065\u5eb7\u7684\u7406\u5ff5\u3001\u6280\u672f\u53ca\u4ea7\u4e1a\u4f53\u7cfb\u5747\u5728\u521d\u7ea7\u9636\u6bb5\uff0c\u4f46\u6b63\u9010\u6b65\u6df1\u5165\u8d4b\u80fd\u533b\u5b66\u8bca\u7597\u3001\u5065\u5eb7\u9884\u9632\u3001\u519c\u4e1a\u80b2\u79cd\u3001\u751f\u6001\u591a\u6837\u6027\u4fdd\u62a4\u7b49\u573a\u666f\u3002<\/p>\n<p>\u672c\u6587\u4ee5\u533b\u7597\u548c\u5065\u5eb7\u9886\u57df\u4e3a\u4f8b\uff0c\u8ba8\u8bba\u6570\u5b57\u751f\u547d\u5065\u5eb7\u6280\u672f\u5bf9\u57fa\u7840\u7814\u7a76\u548c\u8f6c\u5316\u7814\u7a76\u7684\u8d4b\u80fd\u751a\u81f3\u9769\u65b0\u4f5c\u7528\u3002<\/p>\n<p>\u76ee\u524d\u6211\u56fd\u7684\u75be\u75c5\u5206\u7c7b\u4e3b\u8981\u6cbf\u7528ICD\u4f53\u7cfb\uff0c\u5373\u6e90\u81ea100\u591a\u5e74\u524d\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\uff08WHO\uff09\u7f16\u5236\u7684\u300a\u56fd\u9645\u75be\u75c5\u5206\u7c7b\u300b\uff08\u7b80\u79f0ICD\uff09\u3002ICD\u4f9d\u636e\u75c5\u56e0\u3001\u90e8\u4f4d\u3001\u75c5\u7406\u3001\u4e34\u5e8a\u8868\u73b0\u5bf9\u75be\u75c5\u8fdb\u884c\u5206\u7c7b\uff0c\u5b9e\u9645\u64cd\u4f5c\u4e2d\u6309\u89e3\u5256\u90e8\u4f4d\u5206\u7c7b\u8f83\u4e3a\u5e38\u89c1\uff0c\u4f8b\u5982\u7ed3\u76f4\u80a0\u764c\u3001\u9f3b\u7aa6\u708e\u3001\u5e72\u773c\u75c7\u7b49\u30022018\u5e74\uff0c\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u5458\u4f1a\u5f15\u8fdb\u6700\u65b0\u7248ICD-11\u7684\u4e2d\u6587\u7248\u3002<\/p>\n<p>\u4ee5\u57fa\u56e0\u7ec4\u4e3a\u4ee3\u8868\u7684\u751f\u547d\u591a\u7ec4\u5b66\u6b63\u5728\u9010\u6e10\u8865\u5145\u548c\u66f4\u65b0\u4f20\u7edf\u5206\u7c7b\u6807\u51c6\uff0c\u4ee5\u6570\u5b57\u5316\u3001\u4e2a\u4f53\u5316\u3001\u7cfb\u7edf\u5316\u7684\u65b9\u5f0f\u5f15\u53d1\u65b0\u7684\u75be\u75c5\u5206\u7c7b\u8303\u5f0f\u601d\u8003\u3002\u5e76\u5728\u79d1\u5b66\u3001\u653f\u7b56\u53ca\u4ea7\u4e1a\u7b49\u65b9\u9762\u79ef\u7d2f\u65e5\u8d8b\u4e30\u5bcc\u548c\u89c4\u8303\u7684\u4f53\u7cfb\u3002<\/p>\n<p>1990~2003 \u5e74\u95f4\uff0c\u4e0e\u66fc\u54c8\u987f\u539f\u5b50\u5f39\u8ba1\u5212\u3001\u963f\u6ce2\u7f57\u767b\u6708\u8ba1\u5212\u5e76\u79f0\u4e3a\u201c20\u4e16\u7eaa\u4e09\u5341\u79d1\u5b66\u8ba1\u5212\u201d\u7684\u56fd\u9645\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\uff08HGP\uff09\u83b7\u5f97\u4e86\u4e16\u754c\u4e0a\u7b2c\u4e00\u5957\u5b8c\u6574\u7684\u4eba\u7c7b\u57fa\u56e0\u7ec4\u5e8f\u5217\uff0c\u5efa\u7acb\u4e86\u540e\u7eed\u57fa\u56e0\u7ec4\u7814\u7a76\u7684\u53c2\u8003\u5e8f\u5217\u3002<\/p>\n<p>2002~2010 \u5e74\u95f4\uff0c\u56fd\u9645\u4eba\u7c7b\u57fa\u56e0\u7ec4\u5355\u4f53\u578b\u56fe\u8ba1\u5212(HapMap)\u786e\u5b9a\u548c\u7f16\u76ee\u4e86\u4eba\u7c7b\u57fa\u56e0\u7ec4\u5355\u6838\u82f7\u9178\u591a\u6001\u6027(SNP)\u4f4d\u70b9\uff0c\u63d0\u4f9b\u57fa\u56e0\u7a81\u53d8\u7684\u53c2\u8003\u6570\u636e\u96c6\u3002<\/p>\n<p>2008~2012 \u5e74\u95f4\uff0c\u5343\u4eba\u57fa\u56e0\u7ec4\u8ba1\u5212(1000 Genomes Project)\u5f97\u51fa\u4e86\u8fc4\u4eca\u6700\u8be6\u5c3d\u7684\u4eba\u7c7b\u57fa\u56e0\u7ec4\u57fa\u56e0\u591a\u6001\u6027\u56fe\u8c31\uff0c\u8fdb\u4e00\u6b65\u8865\u5145\u4e86\u57fa\u56e0\u7a81\u53d8\u7684\u7cbe\u7ec6\u53c2\u8003\u6570\u636e\u96c6<\/p>\n<p>2006~2015 \u5e74\u95f4\uff0c\u764c\u75c7\u57fa\u56e0\u7ec4\u56fe\u96c6\u8ba1\u5212(TCGA)\u53d1\u73b0\u4e86\u8fd11000 \u4e07\u4e2a\u764c\u75c7\u76f8\u5173\u57fa\u56e0\u7a81\u53d8\uff0c\u521d\u59cb\u5316\u764c\u75c7\u76f8\u5173\u57fa\u56e0\u53c2\u8003\u6570\u636e\u96c6\u3002<\/p>\n<p>\u57fa\u56e0\u7ec4\u8ba1\u5212\u7ed9\u4e34\u5e8a\u57fa\u7840\u7814\u7a76\u548c\u5e94\u7528\u7814\u7a76\u5e26\u6765\u4e86\u4ec0\u4e48\u4ef7\u503c\u5462\uff1f<\/p>\n<p>\u57fa\u56e0\u7b49\u751f\u547d\u7ec4\u5b66\u5927\u6570\u636e\u7684\u7814\u7a76\uff0c\u4f7f\u5f97\u75be\u75c5\u6cbb\u7597\u4ece\u89e3\u5256\u4f4d\u7f6e\u6216\u901a\u8def\u53ef\u805a\u7126\u5230\u5206\u5b50\u75c5\u7406\u9776\u70b9\uff0c\u5b9e\u73b0\u7cbe\u51c6\u533b\u7597\u2014\u2014\u4ee5\u201c\u72d9\u51fb\u67aa\u201d\u7684\u7cbe\u51c6\u6cbb\u7597\uff08\u9776\u5411\u836f\uff09\u6765\u4ee3\u66ff\u201c\u6740\u654c\u4e00\u5343\uff0c\u81ea\u635f\u516b\u767e\u201d\u7684\u201c\u673a\u5173\u67aa\u201d\u6cbb\u7597\u65b9\u5f0f\uff08\u653e\u7597\u548c\u5316\u7597\uff09\u3002\u5176\u4f18\u52bf\u662f\u6cbb\u7597\u66f4\u9ad8\u6548\u3001\u526f\u4f5c\u7528\u66f4\u5c0f\u3001\u9884\u540e\u548c\u590d\u53d1\u98ce\u9669\u6613\u76d1\u6d4b\uff1b\u4f46\u4e5f\u5b58\u5728\u52a3\u52bf\uff0c\u5373\u9776\u70b9\u591a\u4e14\u5173\u8054\uff0c\u4f7f\u5f97\u76ee\u524d\u7684\u7814\u53d1\u6210\u672c\u548c\u6cbb\u7597\u6210\u672c\u9ad8\u3002<\/p>\n<p>\u57fa\u4e8e\u536b\u751f\u7ecf\u6d4e\u5b66\u7684\u8003\u91cf\u548c\u751f\u547d\u7ec4\u5b66\u5927\u6570\u636e\u8fdb\u4e00\u6b65\u79ef\u7d2f\uff0c\u6700\u65b0\u7684\u9776\u5411\u836f\u7814\u53d1\u8def\u5f84\u8bde\u751f\u4e86\u2014\u2014\u6cdb\u764c\u79cd\u9776\u5411\u836f\uff0c\u5373\u9488\u5bf9\u4e00\u4e2a\u9776\u70b9\u6cbb\u7597\u591a\u79cd\u75be\u75c5\uff08\u524d\u6587\u63d0\u5230\u7684\u201c\u5f02\u75c5\u540c\u6cbb\u201d\uff09\uff0c\u4ece\u603b\u4f53\u4e0a\u51cf\u5c11\u7814\u53d1\u53ca\u6cbb\u7597\u6210\u672c\u3002<\/p>\n<p>\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\uff08NIH\uff09\u57282006\u5e74\u7275\u5934\u542f\u52a8\u764c\u75c7\u57fa\u56e0\u7ec4\u8ba1\u5212\uff08The Cancer Genome Atlas\uff0cTCGA\uff09\u3002\u8fd9\u4e2a\u8ba1\u5212\u6d89\u53ca\u52301\u4e07\u4f59\u540d\u60a3\u8005\u768433\u79cd\u4e0d\u540c\u7c7b\u578b\u80bf\u7624\u6837\u672c\uff0c\u5305\u62ec\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u548c\u5176\u4ed6\u751f\u7269\u5206\u5b50\u6570\u636e\uff1b\u901a\u8fc7\u6574\u5408\u7ec4\u5b66\u6570\u636e\uff0c\u5c06\u57fa\u4e8e\u75c5\u7406\u548c\u89e3\u5256\u4f4d\u7f6e\u7b49\u4f20\u7edf\u5206\u7c7b\u65b9\u6cd5\u5212\u5206\u768433\u79cd\u80bf\u7624\uff0c\u91cd\u65b0\u5f62\u621028\u79cd\u6574\u5408\u5206\u5b50\u7fa4\uff08Integrated Clusters, iClusters\uff09\uff0c\u63d0\u51fa\u65b0\u7684\u80bf\u7624\u5206\u7c7b\u2014\u2014\u6cdb\u764c\u79cd\uff08PanCancer\uff09\u3002<\/p>\n<p>\u6cdb\u764c\u79cd\u7684\u63d0\u51fa\uff0c\u4ece\u67d0\u79cd\u7a0b\u5ea6\u4e0a\u9769\u65b0\u4e86\u751f\u7269\u836f\u7814\u53d1\u7684\u8303\u5f0f\uff0c\u5e76\u5c06\u5728\u4e0d\u4e45\u7684\u5c06\u6765\u5927\u5927\u964d\u4f4e\u7814\u53d1\u53ca\u6cbb\u7597\u6210\u672c\u3002<\/p>\n<p>2018\u5e74\uff0cFDA\u52a0\u901f\u6279\u51c6 Bayer \u548cLoxo Oncology \u5171\u540c\u5f00\u53d1\u7684\u6cdb\u764c\u79cd\u9776\u5411\u836f\u62c9\u7f57\u66ff\u5c3c\uff08larotrectinib\uff09\uff08\u5546\u54c1\u540d\uff1a\u7ef4\u6cf0\u51ef\uff09\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u643a\u5e26 NTRK \u57fa\u56e0\u878d\u5408\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u7684\u6210\u4eba\u548c\u513f\u7ae5\u60a3\u8005\uff1b2019\u5e74\uff0c\u7b2c\u4e8c\u6b3e\u9776\u5411NTRK\u7684\u6cdb\u764c\u79cd\u836f\u6069\u66f2\u66ff\u5c3c\uff08Entrectinib\uff09\u88abFDA\u6279\u51c6\u4e0a\u5e02\uff1b2022\u5e74\uff0cNMPA\u6279\u51c6\u62c9\u7f57\u66ff\u5c3c\u548c\u6069\u66f2\u66ff\u5c3c\u5728\u4e2d\u56fd\u76f8\u7ee7\u4e0a\u5e02\uff0c\u4e3a\u5e7f\u5927\u764c\u75c7\u60a3\u8005\u548c\u533b\u751f\u5e26\u6765\u65b0\u7684\u5e0c\u671b\u3002\u636e\u57fa\u56e0\u6167\u4e0d\u5b8c\u5168\u7edf\u8ba1\uff0c\u76ee\u524dFDA\u548c\u6216NMPA\u6279\u51c6\u4e868\u6b3e\u6cdb\u764c\u79cd\u9776\u5411\u836f\/\u65b9\u6848\uff0c\u5176\u4e2d\u5305\u62ec\u56db\u6b3ePD-1\/PD-L1\u514d\u75ab\u6cbb\u7597\u836f\u7269\uff0c\u7ed3\u5408\u4e86\u9776\u70b9\u548c\u514d\u75ab\u673a\u5236\uff0c\u672c\u6587\u4e0d\u4f5c\u5c55\u5f00\u3002<\/p>\n<p>\u6cdb\u764c\u79cd\u9776\u5411\u836f\u9776\u70b9\u6279\u51c6\u57c3\u7f57\u66ff\u5c3c\uff08Erlotinib\uff09NTRK\u57fa\u56e0\u878d\u5408FDA\/NMPA\u62c9\u7f57\u66ff\u5c3c\uff08Larotrectinib\uff09NTRK\u57fa\u56e0\u878d\u5408FDA\/NMPA\u585e\u5c14\u5e15\u66ff\u5c3c (Selpercatinib\uff09RET\u878d\u5408FDA\/NMPA\u8fbe\u62c9\u975e\u5c3c+\u66f2\u7f8e\u66ff\u5c3cBRAF V600E \u7a81\u53d8\u200dFDA\/NMPA\u200d\u200d\u591a\u65af\u5854\u5229\u5355\u6297\uff08Jemperli\uff09dMMRFDA\u6d3e\u59c6\u5355\u6297\uff08Keytruda\uff09MSI-H\u6216dMMRTMB-HFDA\/NMPA\u6069\u6c83\u5229\u5355\u6297\uff08Envafolimab\uff09MSI-H\/dMMRFDA\/NMPA\u65af\u9c81\u5229\u5355\u6297\uff08Serplulimab\uff09MSI-HNMPA<\/p>\n<div>\u8868\uff1aFDA\/NMPA\u6279\u51c6\u7684\u6cdb\u764c\u79cd\u9776\u5411\u836f\uff08\u4e0d\u5b8c\u5168\u7edf\u8ba1\uff09<\/div>\n<div>\u6570\u636e\u6574\u7406\/\u57fa\u56e0\u6167<\/div>\n<p>\u6cdb\u764c\u79cd\u9776\u5411\u836f\u6216\u5176\u4ed6\u4ee5\u751f\u7269\u5206\u5b50\u4e3a\u9776\u70b9\u7684\u9776\u5411\u836f\uff0c\u5728\u6cbb\u7597\u524d\u540e\u5747\u4f34\u968f\u5206\u5b50\u68c0\u6d4b\uff0c\u4ece\u800c\u7b5b\u9009\u51fa\u5408\u9002\u7684\u7528\u836f\u4eba\u7fa4\u8fdb\u884c\u4e2a\u4f53\u5316\u6cbb\u7597\uff0c\u5e76\u8bc4\u4f30\u9884\u540e\u53cd\u5e94\u53ca\u590d\u53d1\u98ce\u9669\uff0c\u8fd9\u4fbf\u662f\u4f34\u968f\u8bca\u65ad\u7684\u4ef7\u503c\u3002<\/p>\n<p>\u65e9\u57281998\u5e74\uff0c\u7b2c\u4e00\u4e2a\u4f34\u968f\u8bca\u65adHer2\/neu\u68c0\u6d4b\u5c31\u4e0e\u4e73\u817a\u764c\u6cbb\u7597\u836f\u7269\u66f2\u59a5\u73e0\u5355\u6297\uff08\u5546\u54c1\u540d\uff1a\u8d6b\u8d5b\u4e01\uff09\u540c\u65f6\u83b7\u6279\u3002\u9762\u5411\u751f\u7269\u9776\u5411\u836f\u7814\u53d1\u7684\u9776\u70b9\u53d1\u73b0\u53ca\u4f34\u968f\u8bca\u65ad\u662f\u5f53\u524d\u80bf\u7624\u7cbe\u51c6\u533b\u7597\u516c\u53f8\u7684\u91cd\u70b9\u3002\u7279\u522b\u662f\u53d7\u7f8e\u56fdExact Sciences\u516c\u53f8\u6253\u9020\u51fa\u5e74\u9500\u91cf10\u4ebf\u7f8e\u91d1\u7684\u91cd\u78c5\u65e9\u7b5b\u4ea7\u54c1Cologuard\uff08\u9488\u5bf9\u7ed3\u76f4\u80a0\u764c\u7b5b\u67e5\uff09\uff0c\u5b9e\u73b010\u5e7440\u500d\u80a1\u4ef7\u7684\u5947\u8ff9\uff0c\u5168\u56fd\u8986\u76d6\u4e14\u7eb3\u5165\u7f8e\u56fd\u8054\u90a6\u533b\u7597\u4fdd\u9669\u3002\u8fd9\u76f4\u63a5\u5e26\u6765\u56fd\u5185\u76f8\u5173\u4f01\u4e1a\u53ca\u8d44\u672c\u7684\u6295\u5165\u3002<\/p>\n<p>2018-2020\u5e74\u7684\u836f\u4f01\u5e02\u573a\u5e26\u6765\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4f34\u968f\u8bca\u65ad\u4ea7\u54c1\u7684\u624e\u5806\uff0c\u96c6\u4e2d\u6279\u51c6\u4e86\u5341\u4f59\u6b3e\u540c\u7c7b\u4ea7\u54c1\uff1b2020\u5e74\uff0c\u968f\u7740\u65e9\u7b5b\u7684\u70ed\u5ea6\uff0c\u548c\u745e\u57fa\u56e0\uff08\u83b1\u601d\u5b81\uff09\u548c\u6cdb\u751f\u5b50\u7684\uff08HCCscreen \uff09\u5728\u809d\u764c\u65e9\u7b5b\u505a\u4e86\u65e9\u671f\u63a2\u7d22\u548c\u5e02\u573a\u6559\u80b2\uff0c\u524d\u8005\u5728\u4e24\u5e74\u540e\u76842022\u5e74\u63a8\u51fa\u591a\u764c\u79cd\u65e9\u7b5b\u4ea7\u54c1\uff08\u5168\u601d\u5b81\uff09\u3002<\/p>\n<p>2021\u5e74\uff0cNMPA\u6279\u51c6\u56fd\u5185\u9996\u4e2a\u65e9\u7b5b\u63a2\u7d22\u6027\u4ea7\u54c1\u4e0a\u5e02\u2014\u2014\u6765\u81ea\u8bfa\u8f89\u5065\u5eb7\u7684\u5e38\u536b\u6e05\u4ea7\u54c1\uff08\u68c0\u6d4bKRAS\u57fa\u56e0\u7a81\u53d8\u53caBMP3\/NDRG4\u57fa\u56e0\u7532\u57fa\u5316\uff09\uff0c\u4f5c\u4e3a\u81f3\u4eca\u516c\u53f8\u5e02\u573a\u53ca\u8d22\u62a5\u4fdd\u969c\u7684\u91cd\u78c5\u4ea7\u54c1\u3002\u7c7b\u4f3c\u4ea7\u54c1\u5305\u62ec\u9510\u7fcc\u751f\u7269\u7684\u5e38\u6613\u8212\u4ea7\u54c1\uff08\u68c0\u6d4bSFRP2\u548cSDC2\u57fa\u56e0\u7532\u57fa\u5316\uff09\u3001\u5eb7\u7acb\u660e\u751f\u7269\u7684\u957f\u5b89\u5fc3\uff08\u68c0\u6d4bSDC2\u57fa\u56e0\u7532\u57fa\u5316\uff09\u3001\u827e\u7c73\u68ee\u7684\u827e\u957f\u5eb7\u7b49\u3002<\/p>\n<p>\u800c\u5934\u90e8\u57fa\u56e0\u673a\u6784\u534e\u5927\u57fa\u56e0\u65e9\u57282019\u5e74\u5206\u62c6\u521d\u80bf\u7624\u65e9\u7b5b\u54c1\u724c\u2014\u2014\u534e\u5927\u6570\u6781\uff0c\u4ee5\u534e\u7518\u5b81\u3001\u534e\u5e38\u5eb7\u3001\u534e\u6d88\u5168\u4e09\u5927\u4ea7\u54c1\u5206\u522b\u5bf9\u5e94\u809d\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u548c\u6cdb\u764c\u79cd\u3002<\/p>\n<p>\u9762\u5bf9\u9ad8\u901a\u91cf\u6d4b\u5e8f\u6210\u672c\u7684\u4f18\u5316\u53ca\u5927\u6570\u636e\u5e26\u6765\u7684\u957f\u8fdc\u4ef7\u503c\uff0c\u4e07\u4eba\u5927\u89c4\u6a21\u6cdb\u764c\u79cd\u524d\u77bb\u6027\u961f\u5217\u7814\u7a76\u4e5f\u5982\u706b\u5982\u837c\uff0c\u5305\u62ec\u71c3\u77f3\u533b\u5b66\u3001\u548c\u745e\u57fa\u56e0\u3001\u9e4d\u8fdc\u57fa\u56e0\u3001\u4e16\u548c\u57fa\u56e0\u7b49\u51e0\u4e4e\u6240\u6709\u5934\u90e8\u80bf\u7624\u7cbe\u51c6\u533b\u7597\u673a\u6784\u5f00\u5c55\u6570\u4ee5\u4ebf\u5143\u7ea7\u7684\u961f\u5217\u7814\u7a76\u9879\u76ee\uff1a<\/p>\n<p>\u542f\u52a8\u65f6\u95f4\u53d1\u8d77\u673a\u6784\u5408\u4f5c\u673a\u6784\u8bf4\u660e2020\u5e74\u71c3\u77f3\u533b\u5b66\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u4e2d\u5c71\u533b\u9662PREDICT\uff1a\u7ea61.4 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Life Sciences \u63a8\u51fa\u4e86\u7b2c\u4e00\u6b3e\u4e8c\u4ee3\u6d4b\u5e8f\u4eea\uff082007\u5e74\u4ee51.55\u4ebf\u7f8e\u5143\u88abRoche\u6536\u8d2d\uff09\uff1b2007\u5e74\uff0c\u6536\u8d2dSolexa NGS\u6280\u672f\uff086\u4ebf\u7f8e\u5143\uff09\u7684Illumina\u3001\u6536\u8d2dAPG\u516c\u53f8\uff081.2\u4ebf\u7f8e\u5143\uff09\u7684ABI\u9646\u7eed\u53d1\u5e03\u66f4\u9ad8\u901a\u91cf\u7684\u6d4b\u5e8f\u4eea\uff0c\u5e76\u5728\u6b21\u5e74\u5c06\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6210\u672c\u964d\u4f4e\u81f310\u4e07\u7f8e\u5143\u4ee5\u4e0b\uff082011\u5e74\u9700\u898138\u4ebf\u7f8e\u5143\uff09\uff1b2023\u5e74\uff0c10\u5e74\u524d\u6536\u8d2dCG\u7684\u534e\u5927\u667a\u9020\uff08MGI\uff09\u5c06\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6210\u672c\u964d\u4f4e\u81f3100\u7f8e\u5143\uff0c\u5e76\u5bf9\u5916\u51fa\u53e3\u6269\u5c55\u81f3\u5168\u7403\u5e02\u573a\u670d\u52a1\u3002<\/p>\n<p>\u5927\u79d1\u5b66\u3001\u5927\u4ea7\u4e1a\u7684\u53d1\u5c55\u79bb\u4e0d\u5f00\u9876\u5c42\u8bbe\u8ba1\u53ca\u76d1\u7ba1\u653f\u7b56\u652f\u6301\u548c\u5f15\u5bfc\u3002<\/p>\n<p>2011\u5e74\uff0c\u7f8e\u56fd\u79d1\u5b66\u9662\u3001\u5de5\u7a0b\u9662\u3001\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\uff08NIH\uff09\u53ca\u79d1\u5b66\u59d4\u5458\u4f1a\u8054\u5408\u53d1\u8868\u6218\u7565\u7814\u7a76\u62a5\u544a\u300a\u8fc8\u5411\u7cbe\u51c6\u533b\u5b66\uff1a\u5efa\u7acb\u751f\u7269\u533b\u5b66\u4e0e\u75be\u75c5\u65b0\u5206\u7c7b\u5b66\u7684\u77e5\u8bc6\u7f51\u7edc\u300b\uff0c\u9996\u6b21\u63d0\u51fa\u201c\u7cbe\u51c6\u533b\u5b66\u201d\u6982\u5ff5\uff0c\u5e76\u63d0\u51fa\u201c\u767e\u4e07\u7f8e\u56fd\u4eba\u57fa\u56e0\u7ec4\u8ba1\u5212\u201d\u7b49\u5927\u9879\u76ee\u5efa\u8bae\u3002<\/p>\n<p>2012\u5e74\uff0c\u77e5\u540d\u533b\u5b66\u6742\u5fd7\u300a\u67f3\u53f6\u5200\u300b\u548c\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u300b\u5148\u540e\u5bf9\u8be5\u62a5\u544a\u8fdb\u884c\u4e86\u8bc4\u4f30\u3002<\/p>\n<p>2014\u5e74\uff0c\u6b27\u76df\u53d1\u5e03\u521b\u65b0\u836f\u7269II\u671f\u8ba1\u5212\u6218\u7565\u7814\u7a76\u8bae\u7a0b\uff0c\u6838\u5fc3\u4e3b\u9898\u662f\u5b9e\u73b0\u201d\u7cbe\u51c6\u533b\u5b66\u201c\u2014\u2014\u9488\u5bf9\u91cd\u70b9\u75be\u75c5\u4e3a\u5408\u9002\u7684\u75c5\u4eba\u5728\u5408\u9002\u7684\u65f6\u95f4\u63d0\u4f9b\u5408\u9002\u7684\u6cbb\u7597\u65b9\u6848\uff1b\u5b89\u6c38\u5728\u53d1\u5e03\u7684\u751f\u7269\u6280\u672f\u884c\u4e1a\u5e74\u62a5\u4e2d\u4e3a\u533b\u836f\u4f01\u4e1a\u63d0\u51fa\u201d\u7cbe\u51c6\u533b\u5b66\u201d\u7684\u5efa\u8bae\u3002<\/p>\n<p>2015\u5e741\u6708\uff0c\u524d\u7f8e\u56fd\u603b\u7edf\u5965\u5df4\u9a6c\u56fd\u60c5\u54a8\u6587\u4e2d\u63d0\u51fa\u201c\u7cbe\u51c6\u533b\u5b66\u8ba1\u5212\u201c\u5021\u8bae\uff08Precision Medicine Initiative\uff0cPMI\uff09\u3002\u63d0\u4f9b2\u4ebf\u4f59\u7f8e\u5143\uff0c\u542f\u52a8\u767e\u4e07\u4eba\u57fa\u56e0\u7ec4\u8ba1\u5212\uff08\u5373\u4e0b\u6587\u7684\u5168\u6c11\u5065\u5eb7\u9879\u76ee\uff09\uff0c\u5f00\u5c55\u4ee5\u764c\u75c7\u4e3a\u4e3b\u7684\u9057\u4f20\u673a\u5236\u548c\u6cbb\u7597\u65b9\u6cd5\u7814\u7a76\u3002\u4e3b\u8981\u5185\u5bb9\u5305\u62ec\uff1a<\/p>\n<p>\uff081\uff09\u8d44\u52a9NIH 1.3\u4ebf\u7f8e\u5143\uff0c\u542f\u52a8\u201c\u767e\u4e07\u4eba\u57fa\u56e0\u7ec4\u8ba1\u5212\u201d\uff0c\u5f81\u96c6100\u4e07\u5fd7\u613f\u8005\uff0c\u6536\u96c6\u57fa\u56e0\u7ec4\u6570\u636e\u4e0e\u4e34\u5e8a\u4fe1\u606f\uff0c\u4ee5\u4fc3\u8fdb\u5bf9\u5065\u5eb7\u548c\u75be\u75c5\u7684\u8ba4\u8bc6\uff0c\u4e3a\u5f62\u6210\u6570\u636e\u5171\u4eab\u673a\u5236\u6253\u4e0b\u57fa\u7840\u3002<\/p>\n<p>\uff082\uff09\u8d44\u52a9\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240(NCI\uff0c\u96b6\u5c5eNIH)7000\u4e07\u7f8e\u5143\uff0c\u7ee7\u7eed\u7f8e\u56fd\u764c\u75c7\u57fa\u56e0\u7ec4\u7814\u7a76\u8ba1\u5212\uff0c\u5bfb\u627e\u5f15\u53d1\u764c\u75c7\u7684\u9057\u4f20\u56e0\u7d20\uff0c\u5f00\u53d1\u66f4\u52a0\u6709\u6548\u7684\u764c\u75c7\u6cbb\u7597\u65b9\u6cd5\uff0c\u5efa\u7acb\u201c\u764c\u75c7\u77e5\u8bc6\u7f51\u7edc\u201d\uff0c\u53ca\u65f6\u5206\u4eab\u521b\u65b0\u6280\u672f\u3002<\/p>\n<p>\uff083\uff09\u8d44\u52a9\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff091000\u4e07\u7f8e\u5143\uff0c\u5efa\u7acb\u65b0\u4e00\u4ee3\u6d4b\u5e8f\u6280\u672f\u7684\u8bc4\u4f30\u548c\u5ba1\u6279\u901a\u9053\uff0c\u83b7\u53d6\u65b0\u7684\u4e13\u5229\u5e76\u63a8\u8fdb\u9ad8\u8d28\u91cf\u6570\u636e\u5e93\u7684\u5f00\u53d1\u3002<\/p>\n<p>\uff084\uff09\u8d44\u52a9\u56fd\u5bb6\u533b\u7597\u4fe1\u606f\u6280\u672f\u534f\u8c03\u529e\u516c\u5ba4(ONC)500\u4e07\u7f8e\u5143\uff0c\u7528\u4e8e\u5236\u5b9a\u4e00\u7cfb\u5217\u7684\u76f8\u5173\u6807\u51c6\u548c\u653f\u7b56\uff0c\u4ee5\u4fdd\u62a4\u9690\u79c1\u548c\u8de8\u7cfb\u7edf\u6570\u636e\u4ea4\u6362\u5b89\u5168\u3002<\/p>\n<div>\u8fd9\u91cc\u9700\u8981\u8865\u5145\u5f3a\u8c03\u7684\u662f\uff0c\u7f8e\u56fd\u7cbe\u51c6\u533b\u5b66\u8ba1\u5212\u7684\u57fa\u77f3\u662f\u7531100\u4e07\u5fd7\u613f\u8005\u7ec4\u6210\u7684\u961f\u5217\u201c\u5168\u6c11\u5065\u5eb7\u9879\u76ee\u201d\uff08All of US Research Program\uff09\u3002\u4e00\u65b9\u9762\uff0c\u662f\u53c2\u4e0e\u8005\u5c06\u81ea\u5df1\u7684\u5065\u5eb7\u6570\u636e\u548c\u751f\u7269\u6837\u672c\u8d21\u732e\u7ed9\u4e00\u4e2a\u4e2d\u5fc3\u5316\u7684\u56fd\u5bb6\u6570\u636e\u5e93\u4ee5\u652f\u6301\u7cbe\u51c6\u533b\u5b66\u7814\u7a76\uff1b\u53e6\u4e00\u65b9\u9762\uff0c\u8be5\u9879\u76ee\u8d1f\u8d23\u4eba\u8868\u793a\uff0c\u91cd\u70b9\u4e0d\u662f\u805a\u7126\u67d0\u4e00\u7c7b\u4eba\u6216\u67d0\u4e00\u7c7b\u75be\u75c5\uff0c\u800c\u662f\uff08\u57fa\u4e8e\u5927\u6570\u636e\uff09\u8bc4\u4f30\u6d89\u53ca\u7684\u591a\u79cd\u75be\u75c5\u7684\u591a\u79cd\u98ce\u9669\u56e0\u5b50\uff0c<\/div>\n<p>\u7f8e\u56fd\u7684\u7cbe\u51c6\u533b\u5b66\u8ba1\u5212\u4e00\u7ecf\u63a8\u51fa\uff0c\u968f\u5373\u5728\u4e16\u754c\u8303\u56f4\u5185\u5f97\u5230\u5e7f\u6cdb\u7684\u5173\u6ce8\uff0c\u5305\u62ec\u82f1\u56fd\u3001\u6cd5\u56fd\u3001\u4e2d\u56fd\u3001\u963f\u8054\u914b\u7b49\u5404\u56fd\u548c\u5730\u533a\u542f\u52a8\u6570\u4ee5\u5341\u4e07\u7ea7\u4e43\u81f3\u767e\u4e07\u7ea7\u57fa\u56e0\u7ec4\u8ba1\u5212\uff08\u4ee5\u82f1\u56fd\u5f00\u5c55\u7684UK100K\u6700\u4e3a\u7a81\u51fa\uff0c\u89c1\u4e0b\u6587\uff09\uff0c\u5e76\u9010\u6e10\u53d1\u5c55\u6210\u4e3a\u5f53\u4eca\u751f\u7269\u533b\u5b66\u9886\u57df\u7684\u4e00\u4e2a\u4e3b\u8981\u6f6e\u6d41\u3002<\/p>\n<p>\u81ea2016\u5e74\u81f3\u4eca\uff0c\u6211\u56fd\u57fa\u56e0\u7ec4\u5927\u79d1\u5b66\u8ba1\u5212\u53d1\u5c55\u8fc5\u731b\uff0c\u52a0\u901f\u6295\u5165\u57fa\u7840\u7814\u7a76\u548c\u4ea7\u4e1a\u53d1\u5c55\uff0c\u63a8\u52a8\u57fa\u56e0\u7b49\u751f\u547d\u7ec4\u5b66\u5927\u6570\u636e\u4e0e\u533b\u7597\u4fe1\u606f\u5316\u3001\u667a\u80fd\u5316\u7684\u878d\u5408\uff1a<\/p>\n<p>2015\u5e74\uff0c\u6211\u56fd\u79d1\u6280\u90e8\u548c\u56fd\u5bb6\u536b\u8ba1\u59d4\u5148\u540e\u53ec\u5f00\u7cbe\u51c6\u533b\u5b66\u6218\u7565\u4e13\u5bb6\u4f1a\u8bae\uff0c\u62df\u57282030\u5e74\u524d\uff0c\u5728\u7cbe\u51c6\u533b\u7597\u9886\u57df\u5171\u6295\u5165600\u4ebf\u5143\uff0c\u5927\u529b\u63a8\u8fdb\u56fd\u5185\u57fa\u56e0\u884c\u4e1a\u53d1\u5c55\uff1b<\/p>\n<p>2016\u5e74\uff0c \u56fd\u5bb6\u79d1\u6280\u91cd\u5927\u4e13\u9879\u201c\u5341\u4e09\u4e94\u201d\u53d1\u5c55\u89c4\u5212\u201c\u7cbe\u51c6\u533b\u5b66\u7814\u7a76\u201d\u91cd\u70b9\u4e13\u9879\u8ba1\u5212\uff082016-2020\uff09\u6b63\u5f0f\u542f\u52a8\uff1b<\/p>\n<p>2017\u5e74\uff0c\u4f5c\u4e3a\u7cbe\u51c6\u533b\u5b66\u4e13\u9879\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\u201c\u4e2d\u56fd\u5341\u4e07\u4eba\u57fa\u56e0\u7ec4\u8ba1\u5212\u201d\u542f\u52a8\uff0c\u7531\u54c8\u5c14\u6ee8\u5de5\u4e1a\u5927\u5b66\u738b\u4e9a\u4e1c\u9662\u957f\u7275\u5934\uff0c\u636e\u9879\u76ee\u56e2\u961f\u7684\u516c\u5f00\u4ecb\u7ecd\uff0c\u622a\u6b622022\u5e748\u6708\u5b8c\u62103\u4e07\u4f59\u4e2a\u6837\u672c\u7684\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\uff0c\u53d1\u73b0\u8d85\u8fc71.1\u4ebf\u4e2a\u65b0\u53d8\u5f02\uff0c\u6784\u5efa\u4e2d\u56fd\u4eba\u53c2\u8003\u57fa\u56e0\u7ec4\u9762\u677f\uff1b<\/p>\n<p>2018\u5e74\uff0c\u4e0a\u6d77\u5e02\u9996\u6279\u5e02\u7ea7\u79d1\u6280\u91cd\u5927\u4e13\u9879\u201c\u56fd\u9645\u4eba\u7c7b\u8868\u578b\u7ec4\u8ba1\u5212\uff08\u4e00\u671f\uff09\u201d\u6b63\u5f0f\u542f\u52a8\uff0c\u7531\u590d\u65e6\u5927\u5b66\u91d1\u529b\u9662\u58eb\u7275\u5934\uff0c\u65e8\u5728\u9996\u6b21\u5efa\u7acb\u56fd\u9645\u9886\u5148\u7684\u4eba\u7c7b\u8868\u578b\u7ec4\u5b66\u7814\u7a76\u5e73\u53f0\uff0c\u4e3a\u5b9e\u8d28\u6027\u63a8\u8fdb\u4eba\u7c7b\u8868\u578b\u7ec4\u5927\u79d1\u5b66\u8ba1\u5212\u6253\u597d\u57fa\u7840\u3002<\/p>\n<p>\u5728\u57fa\u56e0\u7ec4\u3001\u8868\u578b\u7ec4\u7b49\u751f\u547d\u7ec4\u5b66\u8ba1\u5212\u5927\u89c4\u6a21\u5f00\u5c55\u5efa\u7acb\u7ec4\u5b66\u5927\u6570\u636e\u201c\u57fa\u7ebf\u201d\u540c\u65f6\uff0c\u90e8\u5206\u4e00\u7ebf\u57ce\u5e02\u7684\u4e09\u7532\u533b\u9662\u65e9\u5728\u4e94\u5e74\u524d\u5f00\u59cb\u63a2\u7d22\uff0c\u901a\u8fc7\u201c\u4e34\u5e8a\u4fe1\u606f+\u7ec4\u5b66\u5927\u6570\u636e+\u6570\u5b57\u6280\u672f\u201d\u5efa\u7acb\u76f8\u5173\u4e34\u5e8a\u9886\u57df\uff08\u4f8b\u5982\u65b0\u751f\u513f\u3001\u7f55\u89c1\u75c5\u3001\u751f\u6b96\u5065\u5eb7\u3001\u8033\u804b\u3001\u80bf\u7624\u7b49\uff09\u6216\u75c5\u79cd\u7684\u6570\u5b57\u5316\u4e2d\u5fc3\u6216\u5e73\u53f0\uff0c\u4f8b\u5982\u590d\u65e6\u513f\u79d1\u533b\u9662\u3001\u534e\u897f\u533b\u9662\u3001\u534f\u548c\u533b\u9662\u3001\u89e3\u653e\u519b\u603b\u533b\u9662\u6d77\u5357\u533b\u9662\u3002(\u9650\u4e8e\u7bc7\u5e45\uff0c\u66f4\u591a\u8be6\u60c5\u5c06\u5728\u300a2023\u57fa\u56e0\u884c\u4e1a\u84dd\u76ae\u4e66\u300b\u4e2d\u8fdb\u4e00\u6b65\u63a2\u8ba8\u3002)<\/p>\n<p>&nbsp;<\/p>\n<p>\u300a2023\u57fa\u56e0\u884c\u4e1a\u84dd\u76ae\u4e66\u300b\u8bda\u9080\u8054\u5408\u53d1\u5e03\u5355\u4f4d<\/p>\n<p>\u57fa\u56e0\u6167\u8fde\u7eed6\u5e74\u516c\u5f00\u53d1\u5e03<\/p>\n<p>\uff08\u5df2\u5408\u4f5c\uff1a\u7f57\u6c0f\u8bca\u65ad\u3001\u5b57\u8282\u8df3\u52a8\u3001\u661f\u4e91\u57fa\u56e0\uff09<\/p>\n<div><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247512551&amp;idx=1&amp;sn=c85f663051563e930d706360d5f2408b&amp;chksm=eb710350dc068a46711605a979ec7f399ad86f8a1e6c1899e32ec0a031badd801f44b1c49b8b&amp;scene=21#wechat_redirect\">\u300a2022\u57fa\u56e0\u884c\u4e1a\u84dd\u76ae\u4e66\u300b\u53d1\u5e03\u4f1a<\/a><\/div>\n<div><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247502763&amp;idx=1&amp;sn=813b24d0006192fe74eaaa6e8caa0254&amp;chksm=eb71791cdc06f00a1b22b0248fa0acb54a3aef9a68a27566e9524c1b712e187854741492da23&amp;scene=21#wechat_redirect\">\u300a2021\u57fa\u56e0\u884c\u4e1a\u84dd\u76ae\u4e66\u300b\u53d1\u5e03\u4f1a<\/a><\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/RmFicvQBAkgBLLQulNFU0icHW9v9szP7b7RwRbpBl3wSzic4ibeWV8AbiaG0P37O4IklZQAsbgG8X0ib1AekKKwwov4g\/0?wx_fmt=jpeg\" alt=\"0?wx_fmt=jpeg\"\/><\/figure><\/div>\n\n<\/p>\n<p>\u4e09\u3001\u6570\u5b57\u751f\u547d\u5065\u5eb7\u5bf9\u57fa\u7840\u7814\u7a76\u548c\u5e94\u7528\u7814\u7a76\u7684\u542f\u53d1<\/p>\n<\/p>\n<p>\u7ed3\u5408\u751f\u547d\u7ec4\u5b66\u5927\u6570\u636e\u548c\u533b\u7597\u4fe1\u606f\u5316\u7684\u6570\u5b57\u751f\u547d\u5065\u5eb7\uff0c\u6b63\u5728\u9010\u6b65\u6df1\u5165\u542f\u53d1\u751a\u81f3\u6539\u53d8\u57fa\u7840\u7814\u7a76\u548c\u5e94\u7528\u7814\u7a76\u7684\u7814\u7a76\u8303\u5f0f\uff0c\u6700\u5177\u4ee3\u8868\u662f\u57fa\u4e8e\u5927\u6570\u636e\u7684\u4e34\u5e8a\u7814\u7a76\u548c\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n<p>\u5728\u4e34\u5e8a\u7814\u7a76\u65b9\u9762\uff0c\u4f20\u7edf\u7684\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u662f\u5faa\u8bc1\u533b\u5b66\u7684\u91d1\u6807\u51c6\uff0c\u76ee\u524d\u5728\u6b64\u57fa\u7840\u4e0a\u53d1\u5c55\u51fa\u57fa\u4e8e\u5206\u5b50\u751f\u7269\u6807\u5fd7\u7269\u548c\u5206\u5b50\u5206\u578b\u57fa\u7840\u7684\u201c\u4f1e\u8bd5\u9a8c\u201d\u548c\u201c\u7bee\u8bd5\u9a8c\u201d\uff0c\u53ef\u4ee5\u4ece\u4e2d\u533b\u5c42\u9762\u5206\u522b\u7406\u89e3\u4e3a\u201c\u540c\u75c5\u5f02\u6cbb\u201d\u548c\u201c\u5f02\u75c5\u540c\u6cbb\u201d\u3002<\/p>\n<p>\u4f1e\u8bd5\u9a8c\u4ee3\u8868\u4ea7\u54c1\u662f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u5206\u5b50\u5206\u578b\uff08\u4f8b\u5982EGFR\u3001ALK\u3001KRAS\u7b49\uff09\uff1b\u7bee\u8bd5\u9a8c\u4ee3\u8868\u4ea7\u54c1\u53ca\u4e0a\u6587\u63d0\u53ca\u7684\u6cdb\u764c\u79cd\u9776\u5411\u836f\u539f\u808c\u7403\u86cb\u767d\u53d7\u4f53\u6fc0\u9176\uff08TRK\uff09\u6291\u5236\u5242\u62c9\u7f57\u66ff\u5c3c\uff08Larotrectinib\uff09\u3002<\/p>\n<p>\u8fd1\u5e74\uff0c\u9664\u4e86\u4f1e\u8bd5\u9a8c\u548c\u7bee\u8bd5\u9a8c\uff0c\u8fd8\u884d\u751f\u51fa\u5e73\u53f0\u8bd5\u9a8c\uff08platform trial\uff09\u2014\u2014\u5728\u540c\u4e00\u4e2a\u7814\u7a76\u5e73\u53f0\u4e0a\u5e73\u884c\u5f00\u5c55\u5728\u591a\u4e2a\u4e0d\u540c\u5206\u5b50\u6807\u5fd7\u7269\u6307\u5bfc\u4e0b\u7684\u5355\u81c2\u836f\u7269\u8bd5\u9a8c\uff08\u65e0\u9700\u968f\u673a\u5bf9\u7167\u7ec4\uff09\u2014\u2014\u5373\u4e3b\u65b9\u6848\u8bbe\u8ba1\uff08master protocols\uff09\u3002\u5728\u4e3b\u65b9\u6848\u8bbe\u8ba1\u4e0a\u52a0\u4e0a\u8fd1\u5e74\u5174\u8d77\u7684\u771f\u5b9e\u4e16\u754c\u8bc1\u636e\uff08Real World Evidence\uff0cRWE\uff09\uff0c\u5373\u662f\u4e3b\u89c2\u5bdf\u8bd5\u9a8c\uff08MOT\uff09\u30022020\u5e747\u6708\uff0cFDA\u57fa\u4e8eRWE\u5408\u6210\u5bf9\u7167\u81c2\u7684II\u671f\u8bd5\u9a8c\u7ed3\u679c\u9996\u6b21\u6279\u51c6\u4e86\u4e00\u79cd\u6cbb\u7597\u764c\u75c7\u7684\u4e8c\u7ebf\u836f\u7269CD19\u9776\u5411\u5355\u6297Tafasitamab(\u5546\u54c1\u540d\uff1aMONJUVI)\u3002<\/p>\n<\/p>\n<p>\u771f\u5b9e\u4e16\u754c\u6570\u636e\uff08Real World Data, RWD\uff09\u662fRWE\u7684\u6838\u5fc3\u90e8\u5206\uff0c\u4e3b\u8981\u6307\u60a3\u8005\u5065\u5eb7\u72b6\u51b5\u548c\/\u6216\u533b\u7597\u670d\u52a1\u76f8\u5173\u6570\u636e\u3002<\/p>\n<p>\u6211\u56fd\u56fd\u5bb6\u836f\u76d1\u5c40\u8ba4\u5b9a10\u79cd\u7c7b\u578b\u7684\u6570\u636e\u4e3aRWD\uff0c\u5305\u62ec\uff1a<\/p>\n<p>\uff081\uff09\u533b\u9662\u4fe1\u606f\u7cfb\u7edf\u6570\u636e\uff1b\uff082\uff09\u533b\u4fdd\u652f\u4ed8\u6570\u636e\uff1b\uff083\uff09\u767b\u8bb0\u7814\u7a76\u6570\u636e\uff1b\uff084\uff09\u836f\u54c1\u5b89\u5168\u6027\u4e3b\u52a8\u76d1\u6d4b\u6570\u636e\uff1b\uff085\uff09\u81ea\u7136\u4eba\u7fa4\u961f\u5217\u6570\u636e\uff1b\uff086\uff09\u7ec4\u5b66\u6570\u636e\uff1b\uff087\uff09\u6b7b\u4ea1\u767b\u8bb0\u6570\u636e\uff1b\uff088\uff09\u60a3\u8005\u62a5\u544a\u7ed3\u5c40\u6570\u636e\uff1b\uff089\uff09\u6765\u81ea\u79fb\u52a8\u8bbe\u5907\u7684\u4e2a\u4f53\u5065\u5eb7\u76d1\u6d4b\u6570\u636e\uff1b\uff0810\uff09\u5176\u4ed6\u7279\u5b9a\u529f\u80fd\u6570\u636e\uff08\u516c\u5171\u536b\u751f\u76d1\u6d4b\u6570\u636e\u3001\u60a3\u8005\u968f\u8bbf\u6570\u636e\u3001\u60a3\u8005\u7528\u836f\u6570\u636e\uff09\u3002<\/p>\n<p>\u7f8e\u56fd\u56fd\u4f1a\u57282016\u5e74\u901a\u8fc7\u7684\u300a21\u4e16\u7eaa\u6cbb\u7597\u6cd5\u6848\u300b\u4e2d\u63d0\u51fa\uff0c\u65e5\u5e38\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u4ea7\u751f\u7684\u4e30\u5bcc\u591a\u6837\u7684\u771f\u5b9e\u4e16\u754c\u6570\u636e\uff0c\u5982\u7535\u5b50\u5065\u5eb7\u6863\u6848\u548c\u533b\u4fdd\u6570\u636e\u7b49\u6784\u6210\u7684\u201c\u771f\u5b9e\u4e16\u754c\u8bc1\u636e\u201d\u53ef\u4ee5\u4f5c\u4e3a\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u636e\u4e4b\u5916\u7684\u8865\u5145\u8bc1\u636e\u3002\u4e24\u5e74\u540e\uff0cFDA\u516c\u5e03\u4e86\u300a\u771f\u5b9e\u4e16\u754c\u8bc1\u636e\u65b9\u6848\u6846\u67b6\u300b\uff0c\u5e76\u660e\u786e\u63d0\u51faRWE\u53ef\u4ee5\u4f5c\u4e3a\u5408\u6210\u5bf9\u7167\u81c2\uff08synthetic control arm\uff09\u6574\u5408\u5230\u4f20\u7edf\u7684\u5355\u81c2\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n<p>2019\u5e74\uff0c\u771f\u5b9e\u4e16\u754c\u6570\u636e\u9996\u6b21\u7528\u4e8eFDA\u65b0\u836f\u6279\u51c6\uff0c\u5373\u8f89\u745e\u7684\u7231\u535a\u65b0\uff08Ibrance\uff09\u4e0e\u82b3\u9999\u5316\u9176\u6291\u5236\u5242\u6216\u6c1f\u7ef4\u53f8\u7fa4\uff08fulvestrant\uff09\u8054\u5408\u7528\u4e8e\u6cbb\u7597\u60a3\u6709HR +\u548cHER2-\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u7684\u7537\u6027\u60a3\u8005\u30022022\u5e74\uff0cFDA\u4ec5\u57fa\u4e8e\u771f\u5b9e\u4e16\u754c\u8bc1\u636e\u6279\u51c6\u4e86\u9996\u4e2aPROS\uff08PIK3CA\u76f8\u5173\u8fc7\u5ea6\u751f\u957f\u8c31\u7cfb\uff09\u6cbb\u7597\u836f\u7269Vijoice\u3002<\/p>\n<\/p>\n<p>\u5728\u771f\u5b9e\u4e16\u754c\u6570\u636e\u7684\u5e94\u7528\u65b9\u9762\uff0c\u6211\u56fd\u5728\u65e9\u671f\u4fdd\u6301\u7740\u8f83\u5feb\u7684\u540c\u6b65\u53d1\u5c55\u3002<\/p>\n<\/p>\n<p>2019\u5e74\uff0c\u56fd\u5bb6\u836f\u76d1\u5c40\u4e0e\u6d77\u5357\u7701\u8054\u5408\u542f\u52a8\u4e86\u6d77\u5357\u4e34\u5e8a\u771f\u5b9e\u4e16\u754c\u6570\u636e\u5e94\u7528\u8bd5\u70b9\u5de5\u4f5c\u30022020-2021\u5e74\u56fd\u5bb6\u836f\u76d1\u5c40\u5148\u540e\u53d1\u5e03\u4e86\u300a\u771f\u5b9e\u4e16\u754c\u8bc1\u636e\u652f\u6301\u836f\u7269\u7814\u53d1\u4e0e\u5ba1\u8bc4\u7684\u6307\u5bfc\u539f\u5219\uff08\u8bd5\u884c\uff09\u300b\u548c\u300a\u7528\u4e8e\u4ea7\u751f\u771f\u5b9e\u4e16\u754c\u8bc1\u636e\u7684\u771f\u5b9e\u4e16\u754c\u6570\u636e\u6307\u5bfc\u539f\u5219(\u8bd5\u884c)\u300b\u30022021\u5e743\u6708\uff0c\u6211\u56fd\u9996\u6b3eRET\u6291\u5236\u5242\u666e\u62c9\u66ff\u5c3c(pralsetinib)\u6b63\u5f0f\u83b7\u6279\u4e0a\u5e02\uff0c\u8fd9\u662f\u9996\u4e2a\u4f7f\u7528\u6d77\u5357\u535a\u9ccc\u4e50\u57ce\u771f\u5b9e\u4e16\u754c\u6570\u636e\u8f85\u52a9\u4e34\u5e8a\u8bc4\u4ef7\u83b7\u6279\u7684\u836f\u54c1\u3002<\/p>\n<p>\u57fa\u4e8e\u4f20\u7edf\u533b\u5b66\u4fe1\u606f\u3001\u5206\u5b50\u6807\u5fd7\u7269\u4ee5\u53ca\u771f\u5b9e\u4e16\u754c\u6570\u636e\uff0c\u5b66\u672f\u4e0a\u6700\u6709\u4ee3\u8868\u7684\u9879\u76ee\u662f\u82f1\u56fd\u7684UK Biobank\u3002\u82f1\u56fd\u57282010\u5e74\u63d0\u51fa\u4e07\u4eba\u57fa\u56e0\u7ec4\u8ba1\u5212\uff08UK10K\uff09\uff0c\u7531\u77e5\u540d\u7684Wellcome Sanger Institute\u7275\u5934\uff0c\u82f1\u56fd\u536b\u751f\u90e8\u53c2\u4e0e\uff0c2015\u5e74Nature\u520a\u53d1\u4e86\u8be5\u9879\u76ee\u7684\u591a\u7bc7\u7814\u7a76\u6210\u679c\u30022012\u5e74\uff0cUK10K\u62d3\u5c55\u81f3UK 100K\u5373\u5341\u4e07\u4eba\u57fa\u56e0\u7ec4\u8ba1\u5212\uff0c\u5e76\u57282018\u5e74\u5ba3\u5e03\u542f\u52a8500\u4e07\u4eba\u57fa\u56e0\u7ec4\u8ba1\u5212\uff0c\u8fd9\u662f\u8fc4\u4eca\u4e3a\u6b62\u7531\u653f\u5e9c\u4e3b\u5bfc\u7684\u6700\u5927\u7684\u57fa\u56e0\u7ec4\u5b66\u7814\u7a76\u9879\u76ee\u3002<\/p>\n<\/p>\n<p>UK100K\u81f4\u529b\u4e8e\u5728\u533b\u7597\u536b\u751f\u4f53\u7cfb\u63a8\u5e7f\u57fa\u56e0\u7ec4\u5b66\u670d\u52a1\uff0c\u540c\u65f6\u642d\u5efa\u79d1\u7814\u5e73\u53f0\uff0c\u4fc3\u8fdb\u751f\u7269\u533b\u5b66\u7814\u7a76\uff0c\u63a8\u52a8\u57fa\u56e0\u7ec4\u4ea7\u4e1a\u53d1\u5c55\uff0c\u5efa\u7acb\u900f\u660e\u7684\u4f26\u7406\u4f53\u7cfb\u3002<\/p>\n<\/p>\n<p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCqeia7gvOdXU6g1GtzX6jmOyCOiaicy1chq3WUkaEhFpcVibummS4PUZowz9xSfjvuFh6wZTNJY5OzKA.png\" alt=\"RmFicvQBAkgCqeia7gvOdXU6g1GtzX6jmOyCOiaicy1chq3WUkaEhFpcVibummS4PUZowz9xSfjvuFh6wZTNJY5OzKA\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe\uff1aUK100K\u7684\u79d1\u7814\u53ca\u79d1\u7814\u5408\u4f5c\u4f53\u7cfb<\/div>\n<div style=\"text-align: center;\">\uff08\u6765\u6e90\/Congenica\uff09<\/div>\n<p>\u5bf9\u4e8e\u79d1\u7814\u53ca\u4e34\u5e8a\u7684\u5408\u4f5c\u4f53\u7cfb\uff1aUK 100K\u9996\u5148\u5bf9\u57fa\u56e0\u7ec4\u6570\u636e\u548c\u4e34\u5e8a\u6570\u636e\u8fdb\u884c\u8131\u654f\uff0c\u7ecf\u4e13\u5bb6\u59d4\u5458\u4f1a\u5bf9\u79d1\u7814\u4eba\u5458\u63d0\u4ea4\u7684\u79d1\u7814\u65b9\u6848\u8fdb\u884c\u5ba1\u6838\uff0c\u7136\u540e\u5c06\u7814\u7a76\u7ed3\u679c\u901a\u8fc7\u6f5c\u5728\u8bca\u65ad\u7cfb\u7edf\u8fd4\u56de\u81f3\u5404\u533a\u57df\u4e2d\u5fc3\u3002\u5404\u533b\u5b66\u4e2d\u5fc3\u53ef\u5feb\u901f\u83b7\u77e5\u79d1\u7814\u4eba\u5458\u6700\u65b0\u9274\u5b9a\u7684\u53d8\u5f02\uff0c\u5e76\u4f7f\u7528\u66f4\u65b0\u7684\u5206\u6790\u6d41\u7a0b\u5bf9\u75c5\u4f8b\u8fdb\u884c\u91cd\u65b0\u5206\u6790\uff0c\u8fdb\u800c\u5b9e\u73b0\u79d1\u7814\u6210\u679c\u548c\u4e34\u5e8a\u5e94\u7528\u7684\u65e0\u7f1d\u8854\u63a5\uff0c\u5b9e\u73b0\u60a3\u8005\u66f4\u5feb\u53d7\u76ca\u3002<\/p>\n<p>\u57fa\u4e8e\u57fa\u56e0\u53ca\u4e34\u5e8a\u5927\u6570\u636e\u7684\u6574\u5408\u53ca\u4e34\u5e8a\u79d1\u7814\u5408\u4f5c\u4f53\u7cfb\uff0c\u4ee5\u9885\u7f1d\u65e9\u95ed\u4e3a\u4f8b\uff0c\u8bca\u65ad\u7075\u654f\u5ea6\u8fbe\u523085%\u3002<\/p>\n<p>\u56db\u3001\u5bf9\u65b0\u5174\u4ea7\u4e1a\u878d\u5408\u7684\u4fc3\u8fdb\uff1aBT+IT+DT<\/p>\n<p>\u5bf9\u4e8e\u6570\u636e\u7684\u4ef7\u503c\u53ca\u4ea7\u4e1a\u5316\uff0c\u300a\u6570\u5b57\u4e2d\u56fd\u5efa\u8bbe\u6574\u4f53\u5e03\u5c40\u89c4\u5212\u300b\u63d0\u5230\uff1a\u91ca\u653e\u5546\u4e1a\u6570\u636e\u4ef7\u503c\u6f5c\u80fd\uff0c\u52a0\u5feb\u5efa\u7acb\u6570\u636e\u4ea7\u6743\u5236\u5ea6\uff0c\u5f00\u5c55\u6570\u636e\u8d44\u4ea7\u8ba1\u4ef7\u7814\u7a76\uff0c\u5efa\u7acb\u6570\u636e\u8981\u7d20\u6309\u4ef7\u503c\u8d21\u732e\u53c2\u4e0e\u5206\u914d\u673a\u5236\u3002<\/p>\n<p>\u4f5c\u4e3a\u6570\u5b57\u751f\u547d\u5065\u5eb7\uff0c\u6b63\u63a8\u52a8\u751f\u7269\u533b\u5b66\u7b49\u9886\u57df\u7814\u7a76\u8fdb\u5165\u5927\u6570\u636e\u65f6\u4ee3\uff0c\u4fc3\u8fdb\u4ea7\u4e1a\u7684\u878d\u5408\uff0c\u7279\u522b\u662fBT\uff08\u751f\u7269\u6280\u672f\uff09\u3001IT\uff08\u4fe1\u606f\u6280\u672f\uff09\u548cDT\uff08\u6570\u5b57\u6280\u672f\uff09\u7684\u878d\u5408\u3002<\/p>\n<p>\u5176\u4e2d\u7684\u4e00\u4e2a\u6838\u5fc3\u7ebd\u5e26\u662f\u6781\u5177\u5927\u89c4\u6a21\u3001\u7ed3\u6784\u5316\u53ca\u4fe1\u606f\u91cf\u7684\u5927\u6570\u636e\u3002<\/p>\n<p>\u4ece\u6570\u636e\u89c4\u6a21\u4e0a\uff0c\u4ee5\u4e0a\u6587\u63d0\u5230\u7684\u764c\u75c7\u57fa\u56e0\u7ec4\u9879\u76eeTCGA\u8ba1\u5212\u4e3a\u4f8b\uff0c\u57282018\u5e74\u7ed3\u675f\u65f6\u603b\u5171\u4ea7\u751f\u4e862.5EB\u7684\u6570\u636e\uff081EB=1024PB\uff09\u3002\u8fd9\u662f\u4e00\u4e2a\u4ec0\u4e48\u6982\u5ff5\uff0c\u56fd\u5185\u6700\u5927\u7535\u5546\u5e73\u53f0\u201c\u53cc11\u201d\u7684\u5904\u7406\u6570\u636e\u91cf\u4e3a970PB\uff082019\u5e74\u516c\u5f00\u6570\u636e\uff09\u3002\u4e14\u968f\u77402023\u5e74\u767e\u5143\u4eba\u5168\u57fa\u56e0\u7ec4\u7684\u5230\u6765\uff0c\u57fa\u56e0\u7b49\u751f\u547d\u7ec4\u5b66\u5927\u6570\u636e\u89c4\u6a21\u5c06\u5f88\u5feb\u8d85\u8fc7\u4e92\u8054\u7f51\u3002<\/p>\n<p>\u4ece\u7ed3\u6784\u4e0a\uff0c\u4ee5\u57fa\u56e0\u6d4b\u5e8f\u6570\u636e\u4e3a\u4f8b\uff0c\u53ef\u91cf\u5316\uff0c\u4e0e\u4e34\u5e8a\u5927\u591a\u6570\u8868\u578b\uff08\u8868\u578b\u6570\u636e\u5e93\u5728\u5b8c\u5584\u4e2d\uff09\u5177\u6709\u7ebf\u6027\u6216\u7f51\u72b6\u5bf9\u5e94\u5173\u7cfb\uff0c\u4e14\u4ee5\u6587\u672c\u5f62\u5f0f\u6781\u6613\u4e0eIT\u53caDT\u7cfb\u7edf\u878d\u5408\u3002<\/p>\n<p>\u4ece\u4fe1\u606f\u91cf\u4e0a\uff0c\u57fa\u56e0\u7b49\u751f\u547d\u7ec4\u5b66\u4ee3\u8868\u4ee3\u8868\u7740\u751f\u547d\u4f53\u7684\u8fc7\u53bb\uff08\u57fa\u56e0\u7ec4\uff09\u3001\u73b0\u5728\uff08\u57fa\u56e0\u7a81\u53d8\u53ca\u8868\u8fbe\u8c31\u3001\u4ee3\u8c22\u7ec4\uff09\u53ca\u672a\u6765\uff08\u9a71\u52a8\u57fa\u56e0\uff09\uff0c\u6b63\u9010\u6b65\u6df1\u5165\u5e94\u7528\u4e8e\u533b\u7597\u75be\u75c5\u7684\u9632\u63a7\u3001\u5065\u5eb7\u65e9\u7b5b\u3001\u519c\u4e1a\u80b2\u79cd\u3001\u5de5\u4e1a\u7684\u5408\u6210\u751f\u7269\u3001\u751f\u7269\u591a\u6837\u6027\u4fdd\u62a4\u7b49\u7b49\u3002<\/p>\n<p>\u201cBT+IT+DT\u201d\u7684\u878d\u5408\uff0c\u6784\u5efa\u751f\u547d\u5065\u5eb7\u5927\u6570\u636e\uff0c\u5728\u524d\u77bb\u6027\u6218\u7565\u5e03\u5c40\u3001\u4ea7\u4e1a\u94fe\u6574\u5408\u53ca\u5e02\u573a\u5f00\u62d3\u65b9\u9762\u8574\u542b\u91cd\u5927\u4ef7\u503c\u3002<\/p>\n<p>\u4f8b\u5982\uff0c\u5728\u5236\u836f\u9886\u57df\uff0c\u7f57\u6c0f\uff08Roche\uff09\u57282018\u5e74\u4ee519\u4ebf\u7f8e\u5143\u6536\u8d2dFlatiron Health\uff0c\u4ee524\u4ebf\u7f8e\u5143\u6536\u8d2d\u4e86Foundation Medicine\u3002\u00a0\u7ed3\u5408\u524d\u8005\u7684\u4e34\u5e8a\u6570\u636e\u5e73\u53f0\u548c\u540e\u8005\u7684\u764c\u75c7\u60a3\u8005\u57fa\u56e0\u7ec4\u6570\u636e\u5e93\uff0c\u534f\u52a9\u8bbe\u8ba1\u4e34\u5e8a\u8bd5\u9a8c\u3001\u65b0\u836f\u7814\u53d1\u4ee5\u53ca\u5236\u5b9a\u4e2a\u6027\u5316\u6cbb\u7597\u65b9\u6848\uff1b\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff08BMS\uff09\u57282019\u5e74\u5ba3\u5e03\u548cConcerto HealthAI\u8fbe\u6210\u5408\u4f5c\uff0c\u5c06\u5728\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u4e2d\u4f7f\u7528RWD\u548cAI\u6280\u672f\u3002\u4e0e\u836f\u4f01\u5408\u4f5c\u7684\u7c7b\u4f3c\u673a\u6784\u8fd8\u5305\u62ecTempus\uff0cCota healthcare\u7b49\uff0c\u901a\u8fc7\u57fa\u56e0\u6d4b\u5e8f\u3001\u4e34\u5e8a\u6570\u636e\u7ed3\u6784\u5316\u3001\u75c5\u7406\u56fe\u50cf\u5206\u6790\u548c\u751f\u7269\u5efa\u6a21\u5b9e\u73b0\u6570\u636e\u7684\u5408\u89c4\u5546\u4e1a\u4ef7\u503c\u6f5c\u80fd\u91ca\u653e\uff0c\u52a0\u901f\u4e34\u5e8a\u79d1\u7814\u53ca\u836f\u7269\u7814\u53d1\u7b49\uff0c\u6700\u7ec8\u9020\u798f\u533b\u60a3\u3002<\/p>\n<p>\u5c3d\u7ba1\u8fd9\u4e9b\u4e2d\u5c0f\u578b\u673a\u6784\u4e0e\u836f\u4f01\u5f62\u6210\u201c\u8054\u59fb\u201d\uff0c\u4f46\u4ecd\u7136\u4f5c\u4e3a\u914d\u89d2\u63d0\u4f9b\u57fa\u7840\u670d\u52a1\u3002\u7b14\u8005\u8ba4\u4e3a\uff0c\u57fa\u4e8e\u4ea7\u4e1a\u7684\u5468\u671f\u548c\u6570\u636e\u4ef7\u503c\u4f53\u7cfb\u7684\u9010\u6e10\u89c4\u8303\u5316\uff0c\u672a\u676510\u5e74\uff0c\u6570\u5b57\u751f\u547d\u5065\u5eb7\u9886\u57df\u4f1a\u8bde\u751f\u4e0eGoogle\u540c\u7b49\u89c4\u6a21\u7684\u5e73\u53f0\u4f01\u4e1a\u3002\u76ee\u524d\u53ef\u53c2\u8003\u7684\u5e73\u53f0\u4f01\u4e1a\u96cf\u5f62\u662f2023\u5e74JP\u6469\u6839\u5065\u5eb7\u5927\u4f1a\u4e0a\u4eae\u76f8\u7684\u4e00\u4e2a\u673a\u6784\u2014\u2014Velsera\u3002<\/p>\n<p>Velsera\u662f\u7531\u4e09\u5bb6\u751f\u7269\u4fe1\u606f\u4f01\u4e1aPierian\u3001Seven Bridges \u548c UgenTec\u6574\u5408\u800c\u6210\uff0c\u5728\u5168\u7403\u62e5\u6709800\u591a\u540d\u5458\u5de5\uff0cCEO Gavin Nichols\u662f\u5168\u7403\u533b\u5b66\u5f71\u50cf\u548c\u7535\u5b50\u4e34\u5e8a\u516c\u53f8 Calyx\uff08Parexel \u7684\u884d\u751f\u516c\u53f8\uff09 \u524dCEO\uff0c\u4f30\u503c\u7ea6\u4e3a23\u4ebf\u6b27\u5143\uff08\u7ea625\u4ebf\u7f8e\u5143\uff09\u3002<\/p>\n<p>\u8fd9\u8d77\u6536\u8d2d\u7684\u80cc\u540e\u64cd\u5200\u624b\u662f\u745e\u5178\u79c1\u52df\u80a1\u6743\u57fa\u91d1Summa\u00a0Equity\u5408\u4f19\u4ebaHans Cobben\uff0c\u4ed6\u66fe\u662fBlueBee\uff08\u540e\u88abIllumina\u6536\u8d2d\uff09\u521b\u59cb\u4eba\uff0c\u66fe\u670d\u52a1\u4e8e\u963f\u5c14\u5361\u7279\u6717\u8baf\u3001SWIFT\u7b49\u516c\u53f8\u3002<\/p>\n<p>&nbsp;<\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCqeia7gvOdXU6g1GtzX6jmO4EibZyIqNukMtLkRTM0xW4quZhurJ8unP3ZuPEaicT4Dc7BCmUhX4lww.png\" alt=\"RmFicvQBAkgCqeia7gvOdXU6g1GtzX6jmO4EibZyIqNukMtLkRTM0xW4quZhurJ8unP3ZuPEaicT4Dc7BCmUhX4lww\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe\uff1aSeven Brigdges\u7684\u7ec4\u5b66\u6570\u636e\u5206\u6790\u53ca\u7ba1\u7406\u5e73\u53f0<\/div>\n<div style=\"text-align: center;\">\uff08\u6765\u6e90\/Seven Brigdges\uff09<\/div>\n<p>\u4e09\u8005\u7684\u4f18\u52bf\u7ed3\u5408\u7a33\u56fa\u800c\u4e92\u8865\u3002Seven Bridges\u5177\u5907\u5b8c\u5584\u7684\u57fa\u56e0\u6570\u636e\u521d\u7ea7\u5206\u6790\u53ca\u4e91\u5e73\u53f0\uff0cPierian\u64c5\u957f\u6570\u636e\u9ad8\u7ea7\u5206\u6790\u548c\u89e3\u8bfb\uff0cUgenTec\u4e3a\u6570\u5b57\u4e92\u8054\u5b9e\u9a8c\u5ba4\u63d0\u4f9b\u5de5\u4f5c\u6d41\u81ea\u52a8\u5316\u3001\u5927\u89c4\u6a21\u6d4b\u8bd5\u7ed3\u679c\u89e3\u8bfb\u548c\u5b9e\u65f6\u6d1e\u5bdf\u7684\u4fe1\u606f\u7ba1\u7406\u7cfb\u7edf\u3002\u76ee\u524d\u7684\u6846\u67b6\u6784\u5efa\u4e86\u6570\u636e\u5206\u6790\u3001\u89e3\u8bfb\u548c\u5b9e\u9a8c\u5ba4\u81ea\u52a8\u5316\u4fe1\u606f\u7ba1\u7406\u7684\u5f3a\u5927\u4f53\u7cfb\u3002<\/p>\n<p>\u4f46Velsera\u7684\u91ce\u5fc3\u4e0d\u6b62\u4e8e\u6b64\uff0c2023\u5e743\u67088\u65e5\uff0c\u636eCEO Gavin Nichols\u5bf9\u5a92\u4f53\u62ab\u9732\uff0c\u57282023\u5e74\u5e95\u4e4b\u524d\u5c06\u5b8c\u6210\u53e6\u59165-6\u9879\u5e76\u8d2d\u3002\u57fa\u56e0\u6167\u9884\u6d4b\u6f5c\u5728\u88ab\u5e76\u8d2d\u4f01\u4e1a\u53ef\u80fd\u6d89\u53ca\u6d4b\u5e8f\u4eea\u3001\u5355\u7ec6\u80de\u7cfb\u7edf\u3001AI\u6570\u636e\u6316\u6398\u3001\u533b\u7597\u4fe1\u606f\u5316\u3001\u533a\u5757\u94fe\u7b49\u9886\u57df\u3002<\/p>\n<p>\u56fd\u5185\u6b64\u9886\u57df\u7684\u4ee3\u8868\u516c\u53f8\u53ef\u4ee5\u5173\u6ce8\u751f\u547d\u5947\u70b9\u3001\u96f6\u6c2a\u79d1\u6280\uff08LinkDoc)\u3001\u795e\u5dde\u533b\u7597\u3001\u805a\u9053\u79d1\u6280(GeneDock\uff09\u7b49\u3002\u76ee\u524d\u4ecd\u5728\u521d\u7ea7\u53d1\u5c55\u9636\u6bb5\uff0c\u4fa7\u91cd\u70b9\u4e3b\u8981\u5728\u4e34\u5e8a\u4fe1\u606f\u5316\u4e0e\u57fa\u56e0\u5927\u6570\u636e\u7684\u6574\u5408\u3001\u6570\u636e\u5206\u6790\u6d41\u7a0b\u5316\u4ee5\u53ca\u8f85\u52a9\u51b3\u7b56\u7cfb\u7edf\uff0c\u5b8c\u6574\u7684\u7ec4\u5b66\u5927\u6570\u636e\u7ba1\u7406\u7cfb\u7edf\u53ca\u6570\u5b57\u5316\u4e2d\u5fc3\u4ecd\u9700\u8fdb\u4e00\u6b65\u4f18\u5316\u6216\u5efa\u8bbe\uff0c\u672a\u6765\u4ecd\u6709\u5f88\u957f\u7684\u8def\u8981\u8d70\uff0c\u7279\u522b\u662f\u8d44\u91d1\u6295\u5165\u3001\u6570\u636e\u6574\u5408\u53ca\u5f00\u653e\u534f\u4f5c\u5e73\u53f0\u5f00\u53d1\u7b49\u3002<\/p>\n<p>\u4e94\u3001\u533a\u57df\u53d1\u5c55\u7684\u6570\u5b57\u4ea7\u4e1a\u7ade\u8d5b\u53ca\u5b89\u5168\u8fb9\u754c<\/p>\n<p>\u201c\u6570\u5b57\u4e2d\u56fd\u201d\u7684\u5e03\u5c40\uff0c\u9664\u4e86\u65e9\u671f\u7684\u57fa\u7840\u8bbe\u65bd\u5efa\u8bbe\uff0c\u4ece\u4e2d\u957f\u671f\u7684\u5e94\u7528\u524d\u666f\u53ca\u5e02\u573a\u4ef7\u503c\u4e0a\uff0c\u201c\u6570\u5b57\u751f\u547d\u5065\u5eb7\u201d\u5c06\u6781\u53ef\u80fd\u6210\u4e3a\u91cd\u70b9\u5e94\u7528\u9886\u57df\uff0c\u9700\u7eb3\u5165\u521d\u671f\u7684\u89c4\u5212\u53ca\u9876\u5c42\u8bbe\u8ba1\u4e2d\u3002<\/p>\n<p>\u800c\u6839\u636e\u4e0a\u6587\u7684\u521d\u6b65\u5206\u6790\uff0c\u6570\u5b57\u751f\u547d\u5065\u5eb7\u6d89\u53caBT\u3001IT\u53caDT\u7684\u8de8\u5b66\u79d1\u3001\u8de8\u9886\u57df\u7684\u6280\u672f\u53ca\u4ea7\u4e1a\uff0c\u4e14\u5c5e\u4e8e\u524d\u6cbf\u79d1\u6280\u53ca\u65b0\u5174\u4ea7\u4e1a\u9886\u57df\uff0c\u4eba\u624d\u548c\u9879\u76ee\u975e\u5e38\u201c\u7d27\u4fcf\u201d\uff0c\u8fd9\u65b9\u9762\u5c06\u53ef\u89c1\u4e00\u573a\u6fc0\u70c8\u7684\u6570\u5b57\u4ea7\u4e1a\u7ade\u8d5b\u3002<\/p>\n<p>\u76ee\u524d\uff0c\u4ec5\u4ece\u7ec6\u80de\u548c\u57fa\u56e0\u6cbb\u7597\u3001\u5408\u6210\u751f\u7269\u7b49\u4ea7\u4e1a\u65b9\u9762\uff0c\u4e0a\u6d77\u3001\u6df1\u5733\u3001\u5317\u4eac\u3001\u676d\u5dde\u7b49\u5730\u7eb7\u7eb7\u5236\u5b9a\u4e13\u9879\u4ea7\u4e1a\u653f\u7b56\u751a\u81f3\u7acb\u6cd5\uff08\u300a\u6df1\u5733\u7ecf\u6d4e\u7279\u533a\u7ec6\u80de\u548c\u57fa\u56e0\u4ea7\u4e1a\u4fc3\u8fdb\u6761\u4f8b\u300b\u4e8e2023\u5e743\u67081\u65e5\u8d77\u5b9e\u65bd\uff09\uff0c\u800c\u56fd\u5185\u8fd9\u65b9\u9762\u9ad8\u7aef\u4eba\u624d\u7d27\u7f3a\uff0c\u521b\u65b0\u9879\u76ee\u4e5f\u5747\u5728\u53d1\u5c55\u65e9\u4e2d\u671f\uff0c\u56e0\u6b64\u6ca1\u6709\u73b0\u6210\u7684\u201c\u679c\u5b50\u201d\u6458\uff0c\u5728\u4ea7\u4e1a\u89c4\u5212\u65b9\u9762\u5982\u4f55\u914d\u5957\u4e13\u4e1a\u4eba\u624d\u5f15\u8fdb\u3001\u57f9\u80b2\u53ca\u9879\u76ee\u5b75\u5316\uff0c\u662f\u5bf9\u5404\u4e2a\u533a\u57df\u53d1\u5c55\u4e2d\u5fc3\u7684\u5927\u8003\u3002<\/p>\n<p>\u9664\u4e86\u7279\u5927\u57ce\u5e02\uff0c\u6211\u4eec\u770b\u5230\u5357\u4eac\u3001\u957f\u6c99\u3001\u9752\u5c9b\u3001\u5e38\u5dde\u3001\u65e0\u9521\u7b49\u5730\u4e5f\u5728\u79ef\u6781\u5e03\u5c40\u3002\u4f8b\u5982\u957f\u6c99\u6e58\u6c5f\u65b0\u533a\u7684\u57fa\u56e0\u8c37\u4ee5\u57fa\u56e0\u5927\u6570\u636e\u4e3a\u4e3b\u9898\u65b9\u5411\u89c4\u5212\uff0c\u5f15\u8fdb\u4f01\u4e1a50\u5bb6\u4ee5\u4e0a\uff0c\u6253\u9020\u5343\u4ebf\u4ea7\u4e1a\u96c6\u7fa4\uff1b\u9752\u5c9b\u81ea\u8d38\u7247\u533a\u6253\u9020\u65f6\u7a7a\u57fa\u56e0\u8c37\uff0c\u5f00\u53d1\u6d77\u6d0b\u57fa\u56e0\u7ec4\u7b49\u7b49\u3002\u57fa\u56e0\u5927\u6570\u636e\u5728\u5f00\u53d1\u4ea7\u54c1\u548c\u5e94\u7528\u573a\u666f\u4e2d\uff0c\u5c06\u4ece\u6df1\u5ea6\u548c\u5e7f\u5ea6\u4e0a\u4e0e\u533b\u7597\u3001\u519c\u4e1a\u3001\u6d77\u6d0b\u7b49\u6df1\u5ea6\u878d\u5408\uff0c\u62d3\u5bbd\u8fb9\u754c\uff0c\u6316\u6398\u4ef7\u503c\u3002\uff08\u66f4\u591a\u533a\u57df\u7684\u751f\u547d\u5065\u5eb7\u4ea7\u4e1a\u7684\u5206\u6790\u5c06\u5728\u201c\u57fa\u56e0\u6167\u201d\u540e\u7eed\u6587\u7ae0\u4e2d\u4f53\u73b0\uff09\u3002<\/p>\n<p>\u540c\u65f6\uff0c\u5728\u6570\u5b57\u751f\u547d\u5065\u5eb7\u7684\u79d1\u6280\u53ca\u4ea7\u4e1a\u53d1\u5c55\u8fc7\u7a0b\u4e2d\uff0c\u5408\u89c4\u662f\u975e\u5e38\u654f\u611f\u3001\u4e25\u8083\u548c\u91cd\u8981\u7684\u5e95\u7ebf\u3002\u5728\u6570\u636e\u5f00\u53d1\u5e94\u7528\u548c\u5e02\u573a\u53d1\u5c55\u4e2d\uff0c\u5c24\u5176\u8981\u6ce8\u91cd\u9690\u79c1\u4fdd\u62a4\u3001\u751f\u547d\u4f26\u7406\u3001\u6570\u636e\u5b89\u5168\u53ca\u53ef\u63a7\u5171\u4eab\u7b49\u65b9\u9762\u3002<\/p>\n<p>\u56fd\u9645\u79d1\u5b66\u7406\u4e8b\u4f1a\u6570\u636e\u59d4\u5458\u4f1a\uff08CODATA\uff092019\u5e7411\u6708\u53d1\u5e03\u4e86\u300a\u79d1\u7814\u6570\u636e\u5317\u4eac\u5ba3\u8a00\u300b\uff0c\u5176\u539f\u5219\u4e4b\u4e00\u5c31\u662f\u9f13\u52b1\u56fd\u5bb6\u95f4\u6570\u636e\u5f00\u653e\u4e0e\u5171\u4eab\u3002\u6211\u56fd\u653f\u5e9c\u57282021\u5e74\u5148\u540e\u901a\u8fc7\u4e86\u300a\u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u6570\u636e\u5b89\u5168\u6cd5\u300b\u548c\u300a\u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u4e2a\u4eba\u4fe1\u606f\u4fdd\u62a4\u6cd5\u300b\uff0c\u8fdb\u4e00\u6b65\u89c4\u8303\u7684\u6570\u636e\u548c\u4fe1\u606f\u7684\u5f00\u53d1\u5229\u7528\uff0c\u672a\u6765\u9700\u8981\u8fdb\u4e00\u6b65\u7ec6\u5316\u76f8\u5173\u884c\u4e1a\u6307\u5357\uff0c\u660e\u786e\u64cd\u4f5c\u7ec6\u5219\u548c\u7ea2\u7ebf\u3002<\/p>\n<p>\uff08\u9650\u4e8e\u7bc7\u5e45\uff0c\u66f4\u591a\u8be6\u60c5\u8bf7\u89c1\u57fa\u56e0\u6167\u5c06\u8fde\u7eed\u7b2c\u516d\u5e74\u53d1\u5e03\u7684\u300a2023\u57fa\u56e0\u884c\u4e1a\u84dd\u76ae\u4e66\u300b\uff0c\u6b22\u8fce\u53c2\u4e0e\u8054\u5408\u53d1\u5e03\u5408\u4f5c\uff09<\/p>\n<p>\u3010\u6ce8\u3011\u672c\u6587\u57fa\u4e8e\u4ea7\u4e1a\u5206\u6790\u89d2\u5ea6\u8fdb\u884c\u8ba8\u8bba\uff0c\u4e0d\u4f5c\u4e3a\u4e34\u5e8a\u8bca\u7597\u4f9d\u636e\uff1b<\/p>\n<div>\u53c2\u8003\u4fe1\u606f\uff1a\u00a0<\/div>\n<div>\u30101\u3011\u4e2d\u5171\u4e2d\u592e \u56fd\u52a1\u9662\u5370\u53d1\u300a\u6570\u5b57\u4e2d\u56fd\u5efa\u8bbe\u6574\u4f53\u5e03\u5c40\u89c4\u5212\u300b\uff0c2023\uff0chttp:\/\/www.gov.cn\/xinwen\/2023-02\/27\/content_5743484.htm<\/div>\n<div>\u30102\u3011Ma F, Laster K, Dong Z. The comparison of cancer gene mutation frequencies in Chinese and U.S. patient populations. Nat Commun. 2022<\/div>\n<div>\u30103\u3011\u5434\u5bb6\u777f\uff0c\u7cbe\u786e\u533b\u5b665\u5e74\u5386\u7a0b\u7684\u56de\u987e\u4e0e\u601d\u8003(\u4e0a)\uff0c\u300a\u543e\u5bb6\u777f\u89c1\u300b\uff0c2021\uff0chttps:\/\/mp.weixin.qq.com\/s\/NYXesUUzU_QaD47G0TCoyw<\/div>\n<div>\u30104\u3011National Research Council. Toward precision medicine: building a knowledge network for biomedical research and a new taxonomy of disease. 2011, http:\/\/www.nap.edu\/catalog\/13284<\/div>\n<div>\u30105\u3011ICD\u5b98\u7f51\uff1ahttps:\/\/www.who.int\/standards\/classifications\/classification-of-diseases<\/div>\n<div>\u30106\u3011\u7cbe\u51c6\u533b\u5b66\u8ba1\u5212\u5b98\u7f51\uff1ahttps:\/\/obamawhitehouse.archives.gov\/precision-medicine<\/div>\n<div>\u30107\u3011\u9b4f\u6653\u9752\uff0c\u7f8e\u56fd\u7cbe\u51c6\u533b\u5b66\u8ba1\u5212\u53ca\u5176\u542f\u793a\uff0c2016<\/div>\n<div>\u30108\u3011\u5b59\u4e3d\u96c5\uff0c \u5f20\u660e\uff0c \u8d3a\u6797\u3002\u201c\u7cbe\u51c6\u533b\u5b66\u201d\u51b7\u601d\u8003\u3002\u4e2d\u56fd\u79d1\u5b66: \u751f\u547d\u79d1\u5b66\uff0c2016<\/div>\n<div>\u30109\u3011Pamela L. Sankar, Lisa S. Parker. The Precision Medicine Initiative\u2019s All of Us Research Program: an agenda for research on its ethical, legal, and social issues. Genetics in Medicine,2016<\/div>\n<div>\u301010\u3011\u5927\u4eba\u7fa4\u57fa\u56e0\u7ec4\u52a9\u529b\u7fa4\u4f53\u9057\u4f20\u77e5\u8bc6\u53d1\u73b0\u4e0e\u5e94\u7528\u8f6c\u5316\uff0chttps:\/\/baijiahao.baidu.com\/s?id=1741915716530709874&amp;wfr=spider&amp;for=pc<\/div>\n<div>\u301011\u3011\u9776\u5411\u836f\u5217\u8868\uff1ahttps:\/\/www.cancer.gov\/about-cancer\/treatment\/types\/targeted-therapies\/approved-drug-list<\/div>\n<div>\u301012\u3011\u5df2\u6279\u51c6\u7684\u6cdb\u764c\u79cd\u9776\u5411\u836f\uff1ahttps:\/\/pancan.org\/facing-pancreatic-cancer\/treatment\/treatment-types\/targeted-therapy<\/div>\n<div>\u301013\u3011\u79d1\u7814+\u4e34\u5e8a&#8221;\u53cc\u5faa\u73af&#8221;, \u52a0\u901f\u63d0\u5347\u7f55\u89c1\u75c5\u8bca\u65ad &#8211; 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