{"id":7974,"date":"2023-05-15T08:00:00","date_gmt":"2023-05-15T00:00:00","guid":{"rendered":"https:\/\/www.geneclub.net.cn\/index.php\/2023\/05\/15\/5649100\/"},"modified":"2026-04-01T09:13:25","modified_gmt":"2026-04-01T01:13:25","slug":"5649100","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2023\/05\/15\/5649100\/","title":{"rendered":"\u57fa\u56e0\u884c\u4e1a\u7b80\u62a5\uff08228\u671f\uff09"},"content":{"rendered":"

<\/p>\n

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\"RmFicvQBAkgBRib47YYib5y9Jh55ypoNMDXibQlRjCw3yuY1DV37z2KPYAQIMaEZGia8ibSZLgGKiaeupgAib4I727ADmQ\"\/<\/figure><\/div>\n\n

\u56fe\/\u7ed3\u5408\u5168\u740347\u4e2a\u4e0d\u540c\u7956\u6e90\u4e2a\u4f53\u57fa\u56e0\u7ec4\u751f\u6210\u6cdb\u57fa\u56e0\u7ec4\u8349\u56fe(\u6765\u6e90\/Nature)<\/p>\n

\u5927\u73af\u5883<\/div>\n
\u2756 \u9996\u4e2a\u4eba\u7c7b\u6cdb\u57fa\u56e0\u7ec4\u8349\u56fe\u516c\u5e03<\/p>\n

2023\u5e745\u670811\u65e5\uff0c\u4eba\u7c7b\u6cdb\u57fa\u56e0\u7ec4\u53c2\u8003\u8054\u76df(HPRC)\u5728Nature\u548cNature Biotechnology\u671f\u520a\u53d1\u8868\u4e86\u9996\u4e2a\u4eba\u7c7b\u6cdb\u57fa\u56e0\u7ec4\u8349\u56fe\u3002\u8fd9\u4efd\u8349\u56fe\u7ed3\u5408\u4e86\u6765\u81ea47\u4e2a\uff08\u8ba1\u5212\u5728\u672a\u6765\u6269\u5c55\u5230350\u4e2a\u4eba\uff09\u4e0d\u540c\u7956\u6e90\u7684\u4e2a\u4f53\u9057\u4f20\u4fe1\u606f\uff0c\u6bd4\u73b0\u6709\u7684\u5355\u4e00\u53c2\u8003\u57fa\u56e0\u7ec4\u5e8f\u5217(GRCh38)\u65b0\u589e1.19\u4ebf\u4e2a\u78b1\u57fa\u5bf9\u3002<\/p>\n

\u53c2\u8003\u4fe1\u606f>>https:\/\/www.nature.com\/articles\/s41586-023-05896-x<\/div>\n<\/div>\n\n
\n
\"RmFicvQBAkgBRib47YYib5y9Jh55ypoNMDXMHPAANPj6w0yppicHicfeEILSxicQjpxb3OcibktiaHyVt0Ow1TMQ74n6ng\"\/<\/figure><\/div>\n\n
\u56fe\uff1a\u6cdb\u57fa\u56e0\u7ec4\u7ba1\u72b6\u56fe\u8c31\uff08Credit\uff1aDarryl Leja\uff09<\/div>\n

\u2756 \u82f1\u56fd\u9996\u6279\u643a\u5e263\u4ebaDNA\u7684\u201c\u4e09\u4eb2\u5a74\u513f\u201d\u8bde\u751f<\/p>\n

2023\u5e745\u670810\u65e5\uff0c\u636e\u65b0\u534e\u7f51\u62a5\u9053\uff0c\u82f1\u56fd\u4eba\u7c7b\u53d7\u7cbe\u4e0e\u80da\u80ce\u5b66\u7ba1\u7406\u5c40(HFEA)\u8bc1\u5b9e\uff0c\u5728\u76d1\u7ba1\u6846\u67b6\u4e0b\uff0c\u4e3a\u4e86\u9884\u9632\u9057\u4f20\u75c5\uff0c\u82f1\u56fd\u533b\u751f\u901a\u8fc7\u7ebf\u7c92\u4f53\u6350\u8d60\u6cbb\u7597(MDT)\u6280\u672f\u4f7f\u5f97\u9996\u6279\u4e09\u4eb2\u5a74\u513f\uff08\u4f53\u5185\u542b\u6709\u4e09\u4eba\u8131\u6c27\u6838\u7cd6\u6838\u9178\u4fe1\u606f\uff09\u8bde\u751f\uff0c\u9996\u6279\u4e09\u4eb2\u5a74\u513f\u6570\u91cf\u4e0d\u52305\u540d\u3002HFEA\u5f3a\u8c03,\u76ee\u524d\u7ebf\u7c92\u4f53\u6350\u8d60\u6cbb\u7597\u4ecd\u5904\u4e8e\u65e9\u671f\u9636\u6bb5,\u53ea\u6709\u6781\u6709\u53ef\u80fd\u5c06\u4e25\u91cd\u7ebf\u7c92\u4f53\u75be\u75c5\u9057\u4f20\u7ed9\u5b50\u5973\u7684\u4eba\u624d\u6709\u8d44\u683c\u63a5\u53d7\u7ebf\u7c92\u4f53\u6350\u8d60\u6cbb\u7597\u3002<\/p>\n

\u53c2\u8003\u4fe1\u606f>><\/div>\n
https:\/\/www.hfea.gov.uk\/about-us\/news-and-press-releases\/2023-news-and-press-releases\/mitochondrial-donation-treatment<\/div>\n
\u00a0<\/div>\n

\u2756\u201c\u767e\u4e07\u5fae\u751f\u6001\u201d\u56fd\u9645\u5408\u4f5c\u8ba1\u5212\u5b8c\u6210\u8fd16\u4e07\u4f8b\u6837\u672c\u6d4b\u5e8f<\/p>\n

\u8fd1\u65e5\uff0c\u201c\u767e\u4e07\u5fae\u751f\u6001\u201d\u56fd\u9645\u5408\u4f5c\u8ba1\u5212(MMHP)\u9879\u76ee\u7ec4\u5ba3\u5e03\u5b8c\u6210\u8fd16\u4e07\u4f8b\u6837\u672c\u6d4b\u5e8f\u3002MMHP\u4e8e2019\u5e7410\u6708\u542f\u52a8\uff0c\u8ba1\u5212\u5728\u672a\u6765\u4e09\u81f3\u4e94\u5e74\u5185\u5c06\u5bf9100\u4e07\u4efd\u5fae\u751f\u7269\u7ec4\u6837\u54c1\u8fdb\u884c\u6d4b\u5e8f\u5206\u6790\uff0c\u5e76\u7ed8\u5236\u4eba\u4f53\u5fae\u751f\u7269\u7ec4\u56fe\u8c31\u3002<\/p>\n

\u53c2\u8003\u4fe1\u606f>>https:\/\/mp.weixin.qq.com\/s\/3EmzAm0rbGD76i4h0BdkhA<\/div>\n
\u00a0<\/div>\n

\u2756\u7f8e\u56fdAll of Us\u7814\u7a76\u9879\u76ee\u6700\u65b0\u53d1\u5e03\u7ea625\u4e07\u4e2a\u5168\u57fa\u56e0\u7ec4\u5e8f\u5217\u6570\u636e<\/p>\n

\u8fd1\u65e5\uff0c\u7f8e\u56fdAll of Us\u7814\u7a76\u9879\u76ee\u6700\u65b0\u53d1\u5e03\u4e86\u7ea625\u4e07\u4e2a\u5168\u57fa\u56e0\u7ec4\u5e8f\u5217\u6570\u636e\uff0c\u7528\u4e8e\u5e7f\u6cdb\u7684\u7814\u7a76\u7528\u9014\u3002\u76ee\u524d\u8be5\u9879\u76ee\u5df2\u83b7\u5f97\u8d85\u8fc7413,450\u540d\u53c2\u4e0e\u8005\u4fe1\u606f\u3002\u9664\u4e86\u5168\u57fa\u56e0\u7ec4\u5e8f\u5217\uff0c\u8fd8\u5305\u62ec\u6765\u81ea\u8c03\u67e5\u3001\u7535\u5b50\u5065\u5eb7\u8bb0\u5f55\u3001\u7269\u7406\u6d4b\u91cf\u548cFitbit\u8bbe\u5907\u7684\u6570\u636e\u3002<\/p>\n

\u53c2\u8003\u4fe1\u606f>>https:\/\/mp.weixin.qq.com\/s\/NfdxRQhIl4TszMiaZbik2Q<\/div>\n
\u00a0<\/div>\n

\u2756 \u4e16\u536b\u7ec4\u7ec7\u5ba3\u5e03\u65b0\u51a0\u75ab\u60c5\u4e0d\u518d\u6784\u6210\u201c\u56fd\u9645\u5173\u6ce8\u7684\u7a81\u53d1\u516c\u5171\u536b\u751f\u4e8b\u4ef6\u201d<\/p>\n

2023\u5e745\u67085\u65e5\uff0c\u4e16\u536b\u7ec4\u7ec7\u7d27\u6025\u59d4\u5458\u4f1a\u53ec\u5f00\u65b0\u51a0\u75ab\u60c5\u4f8b\u884c\u5b63\u5ea6\u8bc4\u4f30\u4f1a\u8bae\uff0c\u4e16\u536b\u7ec4\u7ec7\u603b\u5e72\u4e8b\u540c\u610f\u59d4\u5458\u4f1a\u5c31\u5f53\u524d\u75ab\u60c5\u5f62\u52bf\u53ca\u672a\u6765\u9632\u63a7\u63d0\u51fa\u7684\u5efa\u8bae\u5e76\u5ba3\u5e03\uff0c\u65b0\u51a0\u75ab\u60c5\u4e0d\u518d\u6784\u6210\u201c\u56fd\u9645\u5173\u6ce8\u7684\u7a81\u53d1\u516c\u5171\u536b\u751f\u4e8b\u4ef6\u201d\u3002<\/p>\n

\u53c2\u8003\u4fe1\u606f>>https:\/\/www.who.int\/news\/item\/05-05-2023-statement-on-the-fifteenth-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-coronavirus-disease-(covid-19)-pandemic<\/div>\n
\u00a0<\/div>\n

\u2756\u00a0\u6e56\u5357\u6e58\u6c5f\u65b0\u533a\u8ba1\u5212\u672a\u67655\u5e74\u51fa\u8d44200\u4ebf\u5143\uff0c\u6253\u9020\u5343\u4ebf\u6bcd\u5b50\u57fa\u91d1\u7fa4<\/p>\n

2023\u5e745\u67086\u65e5\uff0c\u6e56\u5357\u6e58\u6c5f\u65b0\u533a\u5728\u4ea7\u4e1a\u53d1\u5c55\u57fa\u91d1\u53d1\u5e03\u4f1a\u4e0a\u53d1\u5e03\u4e86\u201c\u4eba\u624d\u652f\u6301\u57fa\u91d1+\u79d1\u521b\u5f15\u5bfc\u57fa\u91d1+\u4ea7\u4e1a\u5f15\u5bfc\u57fa\u91d1+\u4e0a\u5e02\u4f01\u4e1a\u6295\u8d44\u5e76\u8d2d\u57fa\u91d1+\u91cd\u5927\u9879\u76ee\u4e13\u9879\u57fa\u91d1\u201d\u4e94\u7c7b\u4ea7\u4e1a\u53d1\u5c55\u57fa\u91d1\uff0c\u5e76\u8ba1\u5212\u672a\u67655\u5e74\u51fa\u8d44200\u4ebf\u5143\uff0c\u6784\u5efa\u8986\u76d6\u4f01\u4e1a\u5168\u751f\u547d\u5468\u671f\u7684\u57fa\u91d1\u751f\u6001\uff0c\u53d1\u6325\u8d22\u653f\u8d44\u91d1\u7684\u6760\u6746\u53ca\u4e58\u6570\u6548\u5e94\uff0c\u6253\u9020\u5343\u4ebf\u6bcd\u5b50\u57fa\u91d1\u7fa4\u3002<\/p>\n

\u53c2\u8003\u4fe1\u606f>>https:\/\/mp.weixin.qq.com\/s\/x3oxjVFBuQaNAPR2LKddbw<\/div>\n
\u00a0<\/div>\n

\u2756\u00a04\u6708\u65b0\u589e\u4fe1\u8d37\u3001\u793e\u878d\u6570\u636e\u73af\u6bd4\u660e\u663e\u4e0b\u6ed1\uff0c\u4f46\u540c\u6bd4\u4fdd\u6301\u591a\u589e\u6001\u52bf<\/p>\n

5\u670811\u65e5\uff0c\u4eba\u6c11\u94f6\u884c\u53d1\u5e03\u76842023\u5e744\u6708\u91d1\u878d\u7edf\u8ba1\u548c\u793e\u4f1a\u878d\u8d44\u6570\u636e\u663e\u793a\uff0c4\u6708\u65b0\u589e\u4eba\u6c11\u5e01\u8d37\u6b3e\u89c4\u6a21\u3001\u793e\u4f1a\u878d\u8d44\u89c4\u6a21\u589e\u91cf\u53d7\u5b63\u8282\u6027\u56e0\u7d20\u7b49\u5f71\u54cd\u73af\u6bd4\u660e\u663e\u4e0b\u6ed1\uff0c\u4f46\u540c\u6bd4\u4fdd\u6301\u591a\u589e\u52bf\u5934\u3002\u5f53\u6708\u6211\u56fd\u4eba\u6c11\u5e01\u8d37\u6b3e\u589e\u52a07188\u4ebf\u5143\uff0c\u540c\u6bd4\u591a\u589e649\u4ebf\u5143\uff1b\u793e\u4f1a\u878d\u8d44\u89c4\u6a21\u589e\u91cf\u4e3a1.22\u4e07\u4ebf\u5143\uff0c\u6bd4\u4e0a\u5e74\u540c\u671f\u591a2729\u4ebf\u5143\u3002\u00a0<\/p>\n

\u53c2\u8003\u4fe1\u606f>>https:\/\/mp.weixin.qq.com\/s\/m0fN3xjci_AfEnfx3Mh9Sg<\/div>\n
\u00a0<\/div>\n
\u5927\u4f01\u4e1a<\/div>\n
\u2756\u00a0\u57fa\u56e0\u7597\u6cd5\u4f01\u4e1a\u51cc\u610f\u751f\u7269\u5b8c\u6210\u8fd1\u4ebf\u5143\u4eba\u6c11\u5e01A\u8f6e\u878d\u8d44<\/p>\n

2023\u5e745\u67086\u65e5\uff0c\u57fa\u56e0\u7597\u6cd5\u516c\u53f8\u51cc\u610f\u751f\u7269\u5ba3\u5e03\u5b8c\u6210\u4e86\u8fd1\u4ebf\u5143A\u8f6e\u878d\u8d44\uff0c\u7531\u501a\u950b\u8d44\u672c\u548c\u534e\u65b9\u8d44\u672c\u5171\u540c\u9886\u6295\uff0c\u4f20\u5316\u79d1\u6280\u57ce\u751f\u79d1\u57fa\u91d1\u3001\u7ea2\u6749\u4e2d\u56fd\u3001\u6000\u6d4e\u8d44\u672c\u7b49\u8ddf\u6295\u3002\u672c\u6b21\u878d\u8d44\u540e\u516c\u53f8\u5c06\u5728\u676d\u5dde\u8427\u5c71\u533a\u94b1\u6e7e\u751f\u7269\u6e2f\u8bbe\u7acb\u603b\u90e8\uff0c\u6574\u5408\u5404\u65b9\u8d44\u6e90\u4ee5\u52a0\u901f\u516c\u53f8\u57fa\u56e0\u6cbb\u7597\u7ba1\u7ebf\u5f00\u53d1\u548c\u6280\u672f\u5e73\u53f0\u5efa\u8bbe\u3002<\/p>\n

\u53c2\u8003\u4fe1\u606f>>https:\/\/mp.weixin.qq.com\/s\/BKK6ZFxaIcsvneN3VPdE0g<\/a><\/div>\n
\u00a0<\/div>\n

\u2756\u00a0\u5408\u6210\u751f\u7269\u4f01\u4e1a\u541b\u8dfb\u57fa\u56e0\u5b8c\u6210\u6570\u5343\u4e07\u5143\u5929\u4f7f\u8f6e\u878d\u8d44\u8fd1\u65e5\uff0c\u82cf\u5dde\u541b\u8dfb\u57fa\u56e0\u79d1\u6280\u6709\u9650\u516c\u53f8\u5ba3\u5e03\u5b8c\u6210\u6570\u5343\u4e07\u5143\u5929\u4f7f\u8f6e\u878d\u8d44\uff0c\u672c\u8f6e\u7531\u4e1c\u65b9\u5609\u5bcc\u3001\u5434\u4e2d\u751f\u7269\u533b\u836f\u4ea7\u4e1a\u53d1\u5c55\u57fa\u91d1\u5171\u540c\u6295\u8d44\u3002\u672c\u8f6e\u878d\u8d44\u5c06\u7528\u4e8e\u52a0\u901f\u81ea\u52a8\u5316\u5b9e\u9a8c\u5e73\u53f0\u4ea7\u54c1\u53ca\u4ea7\u7ebf\u7684\u7814\u53d1\u4ee5\u53caCRO\/CDMO\u4ea7\u54c1\u5e02\u573a\u5316\u8fdb\u7a0b\u7684\u5feb\u901f\u63a8\u8fdb\uff0c\u4e3a\u5168\u7403\u751f\u547d\u79d1\u5b66\u7814\u7a76\u548c\u751f\u7269\u533b\u836f\u4ea7\u4e1a\u63d0\u4f9b\u5f3a\u6709\u529b\u7684\u751f\u6001\u3002<\/p>\n

\u53c2\u8003\u4fe1\u606f>>https:\/\/mp.weixin.qq.com\/s\/E2JhycVryof2exAeiscRNg<\/div>\n
\u00a0<\/div>\n

\u2756\u00a0\u5206\u5b50\u80b2\u79cd\u4f01\u4e1a\u9686\u5e73\u751f\u7269\u5b8c\u6210\u591a\u8f6e\u878d\u8d44\uff0c\u653b\u575a\u751f\u7269\u80b2\u79cd\u4ea7\u4e1a\u5316\u9686\u5e73\u751f\u7269\u662f\u4e00\u5bb6\u805a\u7126\u7389\u7c73\u3001\u5927\u8c46\u7b49\u4e3b\u8981\u519c\u4f5c\u7269\u5173\u952e\u6027\u72b6\u6539\u826f\u53ca\u4ea7\u54c1\u7814\u53d1\u7684\u56fd\u5185\u751f\u7269\u80b2\u79cd\u9886\u519b\u4f01\u4e1a\uff0c\u76ee\u524d\uff0c\u9686\u5e73\u751f\u7269\u5df2\u5b8c\u6210\u591a\u8f6e\u878d\u8d44\uff0c\u56fd\u6295\u96c6\u56e2\u6210\u4e3a\u516c\u53f8\u7b2c\u4e00\u5927\u80a1\u4e1c\uff0c\u9686\u5e73\u9ad8\u79d1\u3001\u65b0\u6d0b\u4e30\u3001\u65b0\u5e0c\u671b\u7b49\u4ea7\u4e1a\u8d44\u672c\u53ca\u7ea2\u6749\u8d44\u672c\u3001\u5927\u6e7e\u533a\u5171\u540c\u5bb6\u56ed\u57fa\u91d1\u7b49\u91d1\u878d\u8d44\u672c\u76f8\u7ee7\u6210\u4e3a\u516c\u53f8\u7684\u6218\u7565\u80a1\u4e1c\u3002<\/p>\n

\u53c2\u8003\u4fe1\u606f>>https:\/\/mp.weixin.qq.com\/s\/PfeLlxP4kYCGTmlPKxEjjQ<\/div>\n
\u00a0<\/div>\n
\u786c\u79d1\u6280<\/div>\n
\u2756 Integrated\u6210\u529f\u5229\u7528\u5408\u6210\u751f\u7269\u5b66\u548c\u4eba\u5de5\u667a\u80fd\u7b5b\u9009\u51fa\u6709\u6548\u6297\u8870\u8001\u836f\u72692023\u5e745\u67084\u65e5\uff0c\u7528\u5408\u6210\u751f\u7269\u5b66\u548c\u4eba\u5de5\u667a\u80fd\u5f00\u53d1\u6297\u8870\u8001\u836f\u7269\u7684\u516c\u53f8Integrated Biosciences\u5728Nature Aging\u53d1\u8868\u8bba\u6587\uff0c\u5229\u7528\u5176\u5f00\u53d1\u7684\u56fe\u5f62\u795e\u7ecf\u7f51\u8def\uff0c\u6210\u529f\u7b5b\u9009\u51fa\u6709\u6d3b\u6027\u7684senolytics\uff08\u8870\u8001\u7ec6\u80de\u6e05\u9664\u5242\uff09\uff0c\u5e76\u4e14\u901a\u8fc7\u8870\u8001\u6a21\u578b\u8bd5\u9a8c\u8bc1\u660e\u4e86\u5176\u6548\u679c\u3002<\/p>\n
\u53c2\u8003\u4fe1\u606f>><\/div>\n
https:\/\/www.nature.com\/articles\/s43587-023-00415-z<\/div>\n
\u00a0<\/div>\n

\u2756 \u4ece\u65e7\u77f3\u5668\u65f6\u4ee3\u5760\u9970\u590d\u539f\u4e86\u53e4\u4eba\u7c7bDNA<\/p>\n

2023\u5e745\u67083\u65e5\uff0cNature\u671f\u520a\u62a5\u544a\u4e86\u4e00\u79cd\u521b\u65b0\u7684\u975e\u7834\u574f\u6027DNA\u63d0\u53d6\u65b9\u6cd5\uff0c\u4e3a\u9274\u522b\u6301\u6709\u7269\u54c1\u7684\u53e4\u4ee3\u4e2a\u4f53\u7684\u8eab\u4efd\u63d0\u4f9b\u76f4\u63a5\u7684\u9057\u4f20\u8bc1\u636e\u3002\u7814\u7a76\u4eba\u5458\u5c06\u8fd9\u79cd\u65b9\u6cd5\u5e94\u7528\u4e8e\u4ece\u4fc4\u7f57\u65af\u4e39\u5c3c\u7d22\u74e6\u6d1e\u4e00\u4e2a\u7ea62\u4e07\u5e74\u5386\u53f2\u7684\u9e7f\u7259\u5760\u9970\u4e2d\u590d\u539f\u7684\u53e4\u4ee3DNA\uff0c\u8868\u660e\u5b83\u53ef\u80fd\u66fe\u4e3a\u4e00\u540d\u6709\u4e9a\u6b27\u5927\u9646\u5317\u90e8\u7956\u5148\u7684\u5973\u6027\u6240\u4f69\u6234\u3002<\/p>\n

\u53c2\u8003\u4fe1\u606f>>https:\/\/www.nature.com\/articles\/s41586-023-06035-2<\/div>\n
\u00a0<\/div>\n

\u2756 \u82f1\u56fd\u7834\u8bd1\u53d1\u80b2\u969c\u788d\u9879\u76ee\u63ed\u793a5500\u4f8b\u7f55\u89c1\u75c5\u7684\u9057\u4f20\u539f\u56e02023\u5e744\u670827\u65e5\uff0c\u82f1\u56fd\u7834\u8bd1\u53d1\u80b2\u969c\u788d(DDD)\u7814\u7a76\u9879\u76ee\u56e2\u961f\u5728The\u00a0New England Journal of Medicine\u671f\u520a\u53d1\u8868\u6587\u7ae0Genomic Diagnosis of Rare Pediatric Disease in the United Kingdom and Ireland\u3002\u6587\u7ae0\u62a5\u544a\u4e86DDD\u7814\u7a76\u9879\u76ee\u7ea65500\u4f8b\u4e25\u91cd\u53d1\u80b2\u969c\u788d\u60a3\u8005\u4e86\u89e3\u5230\u5176\u75be\u75c5\u76f8\u5173\u9057\u4f20\u56e0\u7d20\u3002<\/p>\n

\u53c2\u8003\u4fe1\u606f>>https:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2209046<\/div>\n
\u00a0<\/div>\n
\u65b0\u4ea7\u54c1<\/div>\n
\u2756 \u9996\u6b3e\u7f55\u89c1\u75be\u75c5NF1\u7684\u6cbb\u7597\u836f\u7269\u5728\u4e2d\u56fd\u83b7\u6279<\/p>\n

2023\u5e745\u67088\u65e5\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40(NMPA)\u6279\u51c6\u79d1\u8d5b\u4f18\u00ae\uff08\u82f1\u6587\u5546\u54c1\u540d\uff1aKoselugo\uff0c\u901a\u7528\u540d\uff1a\u786b\u9178\u6c22\u53f8\u7f8e\u66ff\u5c3c\u80f6\u56ca\uff09\u5728\u4e2d\u56fd\u7528\u4e8e\u6cbb\u75973\u5c81\u53ca3\u5c81\u4ee5\u4e0a\u4f34\u6709\u75c7\u72b6\u3001\u65e0\u6cd5\u624b\u672f\u7684\u4e1b\u72b6\u795e\u7ecf\u7ea4\u7ef4\u7624(PN)\u7684I\u578b\u795e\u7ecf\u7ea4\u7ef4\u7624\u75c5(NF1)\u513f\u7ae5\u60a3\u8005\u3002<\/p>\n

\u53c2\u8003\u4fe1\u606f>><\/div>\n
https:\/\/www.nmpa.gov.cn\/zwfw\/sdxx\/sdxxyp\/yppjfb\/20230508125507185.html<\/div>\n
\u00a0<\/div>\n

\u2756\u00a0\u9e4d\u8fdc\u751f\u7269\u80f0\u817a\u764c\u6db2\u4f53\u6d3b\u68c0\u6280\u672fPDACatch\u83b7\u5f97FDA\u7a81\u7834\u6027\u533b\u7597\u5668\u68b0\u8ba4\u8bc1<\/p>\n

2023\u5e745\u67088\u65e5\uff0c\u9e4d\u8fdc\u751f\u7269\u5ba3\u5e03\u5176\u81ea\u4e3b\u7814\u53d1\u7684PDACatch\u68c0\u6d4b\u83b7\u5f97\u7f8e\u56fdFDA\u7684\u7a81\u7834\u6027\u533b\u7597\u5668\u68b0\u8ba4\u8bc1\u3002PDACatch\u662f\u4e00\u79cd\u65b0\u578b\u7684\u57fa\u4e8eDNA\u7532\u57fa\u5316\u3001\u7528\u4e8e\u68c0\u6d4b\u9ad8\u98ce\u9669\u4eba\u7fa4\u4e2d\u80f0\u817a\u764c\u7684\u6db2\u4f53\u6d3b\u68c0\u68c0\u6d4b\u6280\u672f\u3002<\/p>\n

\u53c2\u8003\u4fe1\u606f>>https:\/\/mp.weixin.qq.com\/s\/FNsnUSKm44sh4q0-JR5SSw<\/div>\n
\u00a0<\/div>\n

\u2756 \u6cbb\u7597DMD\u7684\u4e00\u6b21\u6027\u57fa\u56e0\u7597\u6cd5RGX-202\u83b7FDA\u5feb\u901f\u901a\u9053\u8d44\u683c<\/p>\n

\u8fd1\u65e5\uff0cREGENXBIO\u5ba3\u5e03\uff0cFDA\u6388\u4e88\u8be5\u516c\u53f8\u7684\u4e00\u6b21\u6027\u57fa\u56e0\u7597\u6cd5RGX-202\u5feb\u901f\u901a\u9053\u8d44\u683c(FTD)\uff0c\u7528\u4e8e\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7(DMD)\u7684\u6cbb\u7597\u3002RGX-202\u662f\u4e00\u6b3e\u4f7f\u7528AAV8\u8f7d\u4f53\u7684DMD\u57fa\u56e0\u6cbb\u7597\u836f\u7269\uff0c\u9012\u9001\u4e00\u79cd\u542b\u6709\u5929\u7136\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d(dystrophin)C\u7aef\u529f\u80fd\u90e8\u5206\u7684\u521b\u65b0\u578b\u5fae\u578b\u808c\u8425\u517b\u4e0d\u826f\u86cb\u767d\u8f6c\u57fa\u56e0\u3002<\/p>\n

\u53c2\u8003\u4fe1\u606f>>https:\/\/mp.weixin.qq.com\/s\/sbpZRF5xiPB-Rs7IHaE6uA<\/div>\n
\u00a0<\/div>\n
\u597d\u4f1a\u8bae<\/div>\n
\u2756 \u7b2c\u4e94\u5c4a\u5168\u7403\u534e\u4eba\u9057\u4f20\u5b66\u5927\u4f1a\uff0c\u6d59\u6c5f\u7701\u4e49\u4e4c\u5e02\uff0c5\u670817-20\u65e5<\/p>\n

\u7531\u4e2d\u56fd\u9057\u4f20\u5b66\u4f1a\u56fd\u9645\u4ea4\u6d41\u59d4\u5458\u4f1a\u548c\u6d59\u6c5f\u7701\u9057\u4f20\u5b66\u4f1a\u5171\u540c\u4e3b\u529e\u7684\u201c\u7b2c\u4e94\u5c4a\u5168\u7403\u534e\u4eba\u9057\u4f20\u5b66\u5927\u4f1a\u66a8\u751f\u7269\u4ea7\u4e1a\u9ad8\u5cf0\u8bba\u575b\u201d\u5c06\u4e8e2023\u5e745\u670817-20\u65e5\u5728\u6d59\u6c5f\u4e49\u4e4c\u4e3e\u884c\u3002\u672c\u6b21\u5927\u4f1a\u4ee5\u201c\u9057\u4f20\u4e0e\u5065\u5eb7\u201d\u4e3a\u4e3b\u9898\uff0c\u805a\u7126\u201c\u540e\u75ab\u60c5\u7684\u9057\u4f20\u5b66\u201d\uff0c\u5185\u5bb9\u6db5\u76d6\u57fa\u56e0\u7f16\u8f91\u3001\u7ec6\u80de\u548c\u57fa\u56e0\u6cbb\u7597\u3001RNA\u533b\u5b66\u3001\u57fa\u56e0\u68c0\u6d4b\u4e0e\u9057\u4f20\u54a8\u8be2\u3001\u75ab\u60c5\u540e\u7684\u513f\u7ae5\u5065\u5eb7\u4ee5\u53ca\u5206\u5b50\u80b2\u79cd\u7b49\u70ed\u70b9\u95ee\u9898\u3002<\/p>\n

\u53c2\u8003\u4fe1\u606f>>https:\/\/mp.weixin.qq.com\/s\/fnZP5IiAKRnmiADYcLaX_g<\/p>\n

 <\/p>\n

\u2756 \u7b2c\u5341\u5c4a\u4e2d\u56fd\u4f53\u5916\u8bca\u65ad\u4ea7\u4e1a\u53d1\u5c55\u5927\u4f1a\uff0c\u6c5f\u897f\u7701\u5357\u660c\u5e02\uff0c5\u670828-29\u65e5<\/div>\n

\u7531\u5168\u56fd\u536b\u751f\u4ea7\u4e1a\u4f01\u4e1a\u7ba1\u7406\u534f\u4f1a\u533b\u5b66\u68c0\u9a8c\u4ea7\u4e1a\u5206\u4f1a\u4e3b\u529e\uff0c\u5168\u56fd\u536b\u751f\u4ea7\u4e1a\u4f01\u4e1a\u7ba1\u7406\u534f\u4f1a\u5b9e\u9a8c\u533b\u5b66\u5206\u4f1a\u3001\u4e0a\u6d77\u5e02\u5b9e\u9a8c\u533b\u5b66\u7814\u7a76\u9662\u3001VIEW\u671f\u520a\u534f\u529e\u7684\u7b2c\u5341\u5c4a\u4e2d\u56fd\u4f53\u5916\u8bca\u65ad\u4ea7\u4e1a\u53d1\u5c55\u5927\u4f1a\u5b9a\u4e8e2023\u5e745\u670828-29\u65e5\u5728\u5357\u660c\u56fd\u9645\u535a\u89c8\u57ce\u7eff\u5730\u94c2\u745e\u9152\u5e97\u4f1a\u8bae\u4e2d\u5fc3\u9686\u91cd\u4e3e\u884c\u3002<\/p>\n

\u53c2\u8003\u4fe1\u606f>>https:\/\/mp.weixin.qq.com\/s\/5CBvXJdNAgTcG1BA_VT-xg<\/a><\/div>\n
\u00a0<\/div>\n

\u2756 \u7b2c\u4e94\u5c4a\u5168\u56fd\u8868\u89c2\u9057\u4f20\u4fe1\u606f\u5b66\u7814\u8ba8\u4f1a\u66a8\u8868\u89c2\u9057\u4f20\u4fe1\u606f\u5b66\u4e13\u59d4\u4f1a\u6210\u7acb\u5927\u4f1a\uff0c\u6d59\u6c5f\u7701\u6e29\u5dde\u5e02\uff0c6\u67082-4\u65e5<\/p>\n

\u7531\u4e2d\u56fd\u751f\u7269\u4fe1\u606f\u5b66\u5b66\u4f1a\u4e3b\u529e\uff0c\u4e2d\u56fd\u751f\u7269\u4fe1\u606f\u5b66\u8868\u89c2\u9057\u4f20\u4fe1\u606f\u5b66\u4e13\u4e1a\u59d4\u5458\u4f1a\u3001\u6e29\u5dde\u533b\u79d1\u5927\u5b66\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u5b66\u9662\u3001\u9644\u5c5e\u773c\u89c6\u5149\u533b\u9662\u627f\u529e\u3001\u6d59\u6c5f\u7701\u751f\u7269\u4fe1\u606f\u5b66\u5b66\u4f1a\u534f\u529e\u7684\u7b2c\u4e94\u5c4a\u5168\u56fd\u8868\u89c2\u9057\u4f20\u4fe1\u606f\u5b66\u7814\u8ba8\u4f1a\u66a8\u8868\u89c2\u9057\u4f20\u4fe1\u606f\u5b66\u4e13\u59d4\u4f1a\u6210\u7acb\u5927\u4f1a\u5c06\u4e8e2023\u5e746\u67082-4\u65e5\u5728\u6d59\u6c5f\u6e29\u5dde\u6e29\u5fb7\u59c6\u9152\u5e97\u4e3e\u884c\u3002<\/p>\n

\u53c2\u8003\u4fe1\u606f>>https:\/\/mp.weixin.qq.com\/s\/kT1TvGqRsve7Gmq5o1zWbw<\/a><\/div>\n
\u00a0<\/div>\n
\u5f80\u671f\u63a8\u8350<\/div>\n
18\u5bb6\u673a\u6784\u8d1f\u8d23\u4eba\u5171\u805a\u57fa\u56e0\u884c\u4e1a\u7814\u8ba8\u4f1a<\/a><\/div>\n
\u4e13\u8bbf\u738b\u827a\uff1a\u57fa\u56e0\u68c0\u6d4b\u4e3a\u7f55\u89c1\u75c5\u8bca\u65ad\u63d0\u4f9b\u6709\u529b\u6b66\u5668<\/a><\/div>\n
\u57fa\u56e0\u884c\u4e1a\u7b80\u62a5\uff08227\u671f\uff09<\/a><\/div>\n
\u3010\u58f0\u660e\u3011\u4e3a\u4e86\u63a8\u52a8\u57fa\u56e0\u53ca\u6570\u5b57\u751f\u547d\u5065\u5eb7\u79d1\u6280\u63a8\u5e7f\u3001\u4ea7\u4e1a\u53d1\u5c55\u53ca\u653f\u4ea7\u5b66\u7814\u7528\u8fde\u63a5\uff0c\u57fa\u56e0\u6167\u79c9\u6301\u4e13\u4e1a\u3001\u8d4b\u80fd\u3001\u4e2d\u7acb\u7684\u7acb\u573a\u6536\u96c6\u3001\u5206\u6790\u53ca\u53d1\u5e03\u76f8\u5173\u4fe1\u606f\u3002\u4f46\u7531\u4e8e\u65f6\u6548\u6027\u53ca\u884c\u4e1a\u7279\u6b8a\u6027\uff0c\u6240\u520a\u767b\u5185\u5bb9\u4ec5\u4f9b\u7814\u7a76\u53c2\u8003\uff0c\u672a\u7ecf\u8bf4\u660e\u4e0d\u4f5c\u4e3a\u51b3\u7b56\u4f9d\u636e\uff1b\u672c\u6587\u76f8\u5173\u4fe1\u606f\u4e0d\u4ee3\u8868\u57fa\u56e0\u6167\u7684\u89c2\u70b9\uff1b\u57fa\u56e0\u6167\u5e73\u53f0\u520a\u767b\u7684\u539f\u521b\u5185\u5bb9\u7684\u77e5\u8bc6\u4ea7\u6743\u4e3a\u201c\u57fa\u56e0\u6167\u201d\u5546\u6807\u62e5\u6709\u8005\u53ca\u76f8\u5173\u6743\u5229\u4eba\u6240\u6709\uff1b\u6b22\u8fce\u8f6c\u8f7d\uff0c\u8f6c\u8f7d\u8bf7\u7533\u8bf7\u5e76\u6ce8\u660e\u6765\u6e90\u3002\u6b22\u8fce\u4e2a\u4eba\u53ca\u673a\u6784\u6295\u7a3f\u53ca\u5408\u4f5c\u3002<\/div>\n

\u00a0\u5173\u4e8e\u57fa\u56e0\u6167\u00a0<\/p>\n

\u57fa\u56e0\u6167\u6210\u7acb\u4e8e2015\u5e74\uff0c\u4e13\u6ce8\u6570\u5b57\u751f\u547d\u5065\u5eb7\u4ea7\u4e1a\u77e5\u8bc6\u670d\u52a1\u3002\u521b\u59cb\u56e2\u961f\u6df1\u8015\u884c\u4e1a\u4e00\u7ebf\u5341\u4f59\u5e74\uff0c\u79c9\u6301\u201c\u4f7f\u8fde\u63a5\u4ea7\u751f\u4ef7\u503c\uff0c\u7528\u6570\u636e\u770b\u89c1\u672a\u6765\u201d\u7684\u7406\u5ff5\uff0c\u57fa\u4e8e\u4ea7\u4e1a\u667a\u5e93\u548c\u4e13\u4e1a\u5185\u5bb9\uff0c\u63d0\u4f9b\u4ea7\u4e1a\u89c4\u5212\u3001\u884c\u7814\u54a8\u8be2\u3001\u79d1\u6280\u63a8\u5e7f\u7b49\u670d\u52a1\u3002\u8fde\u7eed\u4e94\u5e74\u53d1\u5e03\u884c\u4e1a\u84dd\u76ae\u4e66\uff0c\u88ab\u56fd\u5bb6\u53ca\u7701\u5e02\u7ea7\u4ea7\u4e1a\u62a5\u544a\u6536\u5f55\uff0c\u534f\u52a9\u5b66\u4f1a\u4e13\u5bb6\u7b49\u7ec4\u7ec7\u4ea7\u4e1a\u673a\u6784\u53d1\u5e03\u591a\u9879\u884c\u4e1a\u5171\u8bc6\uff0c\u63a8\u52a8\u751f\u547d\u79d1\u6280\u666e\u60e0\u548c\u4ea7\u4e1a\u521b\u65b0\u53d1\u5c55\u3002<\/div>\n
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