{"id":7941,"date":"2023-08-11T16:02:00","date_gmt":"2023-08-11T08:02:00","guid":{"rendered":"https:\/\/www.geneclub.net.cn\/index.php\/2023\/08\/11\/485449\/"},"modified":"2026-04-07T16:48:23","modified_gmt":"2026-04-07T08:48:23","slug":"485449","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2023\/08\/11\/485449\/","title":{"rendered":"\u4e3a\u4ec0\u4e48\u57fa\u56e0\u79d1\u6280\u80fd\u591f\u4e0e\u4eba\u5de5\u667a\u80fd\u5e76\u5217\uff0c\u4f5c\u4e3a\u672a\u6765\u4ea7\u4e1a\uff1f"},"content":{"rendered":"<p><!-- wechat_content_hash: 061249dcf65785c4 --><\/p>\n<p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDD8OLuPKNZO9uDa83kfKuseJzT4hia2LRmtjzibhsics2LQq2n3sgU8nibHXvj1BCupPoA6u5UWvmwSg.png\" alt=\"RmFicvQBAkgDD8OLuPKNZO9uDa83kfKuseJzT4hia2LRmtjzibhsics2LQq2n3sgU8nibHXvj1BCupPoA6u5UWvmwSg\"\/><\/figure><\/div>\n\n<\/p>\n<div>\u5728\u6211\u56fd\u201c\u5341\u56db\u4e94\u201d\u89c4\u5212\u4e2d\uff0c\u57fa\u56e0\u53ca\u751f\u7269\u6280\u672f\u4f5c\u4e3a\u4e03\u5927\u524d\u6cbf\u653b\u5173\u9886\u57df\u4e4b\u4e00\uff0c\u751f\u7269\u6280\u672f\u4f5c\u4e3a\u4e5d\u5927\u6218\u7565\u6027\u65b0\u5174\u4ea7\u4e1a\u4e4b\u4e00\uff0c\u57fa\u56e0\u6280\u672f\u4f5c\u4e3a\u524d\u77bb\u8c0b\u5212\u672a\u6765\u4ea7\u4e1a\u4e4b\u4e00\uff0c\u4e0e\u4eba\u5de5\u667a\u80fd\u5171\u4e3a\u56fd\u4e4b\u91cd\u5668\u3002\u672c\u6587\u8fde\u8f7d\u300a2023\u57fa\u56e0\u884c\u4e1a\u84dd\u76ae\u4e66\u300b\u5185\u5bb9\uff0c\u5206\u522b\u4ece\u5206\u5b50\u9176\u3001\u5355\u7ec6\u80de\u3001\u6d4b\u5e8f\u4eea\u3001\u57fa\u56e0\u6cbb\u7597\u7b49\u6280\u672f\u5185\u6838\u5c55\u5f00\u5206\u4eab\u57fa\u56e0\u79d1\u6280\u7684\u4ef7\u503c\u548c\u9b45\u529b\u3002<\/div>\n<div>\u76ee\u5f55<\/div>\n<div>1.\u57fa\u56e0\u884c\u4e1a\u4e0a\u6e38\u6838\u5fc3\u539f\u6599\uff1a\u5206\u5b50\u751f\u7269\u9176<\/div>\n<div>2.\u4ece\u5355\u4e2a\u7ec6\u80de\u5206\u8fa8\u7387\u89e3\u7801\u751f\u547d\uff1a\u5355\u7ec6\u80de\u5206\u6790\u7cfb\u7edf<\/div>\n<div>3.\u57fa\u56e0\u884c\u4e1a\u57fa\u7840\u6280\u672f\uff1a\u57fa\u56e0\u6d4b\u5e8f\u53ca\u751f\u4ea7\u5e73\u53f0<\/div>\n<div>4.\u57fa\u56e0\u6cbb\u7597\u4ea7\u4e1a\u5316\u6838\u5fc3\uff1a\u57fa\u56e0\u7f16\u8f91\u53ca\u57fa\u56e0\u6cbb\u7597\u8f7d\u4f53<\/div>\n<div>5.\u5408\u6210\u751f\u7269\u6838\u5fc3\u6280\u672f\uff1a\u9ad8\u901a\u91cf\u57fa\u56e0\u5408\u6210\u53ca\u751f\u4ea7\u5e73\u53f0<\/div>\n<div>01 \u57fa\u56e0\u884c\u4e1a\u4e0a\u6e38\u6838\u5fc3\u539f\u6599<\/div>\n<div>\u5206\u5b50\u751f\u7269\u9176<\/div>\n<p>\u968f\u7740\u5206\u5b50\u8bca\u65ad\u8fd1\u5e74\u5feb\u901f\u53d1\u5c55\uff0c\u5206\u5b50\u9176\u6210\u4e3a\u57fa\u56e0\u884c\u4e1a\u4e0a\u6e38\u6838\u5fc3\u539f\u6599\uff0c\u5e7f\u6cdb\u5e94\u7528\u4e8e\u9776\u5411\u6355\u83b7\u3001\u5efa\u5e93\u4ee5\u53ca\u6d4b\u5e8f\u3001\u5408\u6210\u7b49\u751f\u4ea7\uff0c\u5e76\u53d1\u5c55\u5230CRISPR\u5feb\u901f\u8bca\u65ad\u7b49\u7ec8\u7aef\u8bd5\u5242\u9886\u57df\u3002<\/p>\n<\/p>\n<p>\u5e38\u7528\u5206\u5b50\u9176\u5305\u62ecDNA\u805a\u5408\u9176\u3001\u9006\u8f6c\u5f55\u9176\u3001\u5185\u5207\u9176\u3001\u4fee\u9970\u9176\u3001\u8fde\u63a5\u9176\u7b49\u3002\u8fd1\u5e74\u5174\u8d77\u7684CRISPR-Cas \u7cfb\u7edf\uff0c\u5176\u4e2d\u7684 Cas \u86cb\u767d\u5373\u662f\u6838\u9178\u526a\u5207\u9176\u3002<\/p>\n<\/p>\n<p>\u5206\u5b50\u9176\u7684\u7814\u53d1\u6d41\u7a0b\u76f8\u5bf9\u6210\u719f\uff0c\u4e00\u822c\u9075\u5faa\u201c\u8bbe\u8ba1-\u6784\u5efa-\u6d4b\u8bd5-\u5b66\u4e60\u201d\u7684\u8fc7\u7a0b\uff0c\u5305\u62ec\u57fa\u4e8e\u76ee\u6807\u529f\u80fd\u786e\u7acb\u521d\u59cb\u5929\u7136\u9176\u4ee5\u53ca\u5bf9\u5e94\u57fa\u56e0\u3001\u57fa\u56e0\u514b\u9686\u548c\u8868\u8fbe\u3001\u5e8f\u5217\u7a81\u53d8\u3001\u6784\u5efa\u7ed3\u6784\u529f\u80fd\u6a21\u578b\u3001\u4f53\u5916\u8fdb\u884c\u86cb\u767d\u8868\u8fbe\u548c\u7eaf\u5316\u3002\u8fd9\u4e2a\u8fc7\u7a0b\u9700\u8981\u4ea4\u53c9\u5b66\u79d1\u6280\u672f\u4eba\u624d\u3001\u73af\u8282\u4f17\u591a\u3001\u5468\u671f\u957f\uff0c\u6784\u5efa\u5e73\u53f0\u5316\u7684\u5f00\u53d1\u4f53\u7cfb\u548c\u751f\u4ea7\u4f53\u7cfb\u7684\u95e8\u69db\u9ad8\u3002<\/p>\n<\/p>\n<p>\u5176\u4e2d\uff0c\u5b9a\u5411\u8fdb\u5316\u662f\u9176\u7684\u6700\u524d\u6cbf\u7684\u6280\u672f\u4e4b\u4e00\u30022018\u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u83b7\u5f97\u8005\u4e4b\u4e00\u662f\u9176\u5b9a\u5411\u8fdb\u5316\u5148\u9a71Frances H. Arnold\u3002\u9176\u5b9a\u5411\u8fdb\u5316\u5305\u62ec\u57fa\u56e0\u7a81\u53d8\u5e93\u5efa\u7acb\u548c\u9ad8\u901a\u91cf\u7b5b\u9009\u4e24\u4e2a\u6b65\u9aa4\u3002\u4f20\u7edf\u7684\u5b9a\u5411\u8fdb\u5316\u662f\u901a\u8fc7\u6613\u9519PCR\uff08error-prone PCR\uff09\u5efa\u7acb\u5e9e\u5927\u7684\u7a81\u53d8\u5e93\uff0c\u7136\u540e\u901a\u8fc7\u5e73\u677f\/\u5fae\u5b54\u677f\/\u6d41\u5931\u7ec6\u80de\uff08FACS \u6cd5\uff09\uff1b\u6700\u65b0\u7684\u9176\u5b9a\u5411\u8fdb\u5316\uff0c\u7ed3\u5408\u5e8f\u5217\u53ca\u7ed3\u6784\u4fe1\u606f\u548c\u8ba1\u7b97\u673a\u8f85\u52a9\u8bbe\u8ba1\u3002<\/p>\n<\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgB5W5ICbmuwpHobBBEsfUyP6L4pIbrGC6OkOZJOC92ugdMTnwE8jgjrSPsXicUfpgOcIws8HhicpYnw.png\" alt=\"RmFicvQBAkgB5W5ICbmuwpHobBBEsfUyP6L4pIbrGC6OkOZJOC92ugdMTnwE8jgjrSPsXicUfpgOcIws8HhicpYnw\"\/><\/figure><\/div>\n\n<\/p>\n<p>\u5177\u6709\u4ee3\u8868\u6027\u7684\u5206\u5b50\u9176\u673a\u6784\u5305\u62ec\u7f57\u6c0f\u8bca\u65ad\u3001\u5b89\u6377\u4f26\u3001\u8d5b\u9ed8\u98de\u3001\u6c83\u5947\u9176\u79d1\uff08Watchmaker Genomics\uff09\u3001\u8bfa\u552f\u8d5e\u3001\u83f2\u9e4f\u751f\u7269\u3001\u5eb7\u4e3a\u4e16\u7eaa\u3001\u7fca\u5723\u751f\u7269\u3001\u7231\u535a\u6cf0\u514b\u7b49\u3002<\/p>\n<\/p>\n<p>\u5f53\u524d\u56fd\u5185\u5206\u5b50\u9176\u4ea7\u4e1a\uff0c\u968f\u7740\u66f4\u591a\u5382\u5546\u7684\u6d8c\u5165\uff0c\u56fd\u4ea7\u5316\u7ea2\u5229\u6b63\u5728\u6d88\u5931\uff0c\u6b63\u7ecf\u5386\u4f4e\u4ef7\u7b56\u7565\u7684\u7ade\u4e89\u5468\u671f\uff0c\u9762\u4e34\u6fc0\u70c8\u7684\u5e02\u573a\u7ade\u4e89\u3002\u4ece\u5e02\u573a\u89d2\u5ea6\uff0c\u5934\u90e8\u4f01\u4e1a2022\u5e74\u8d77\u79ef\u6781\u5e03\u5c40\u6d77\u5916\u5e02\u573a\u3002\u6b64\u5916\uff0c\u57fa\u56e0\u5408\u6210\u6216\u5408\u6210\u751f\u7269\u4f5c\u4e3a\u65b0\u5174\u5e02\u573a\u9886\u57df\uff1b\u4ece\u6280\u672f\u89d2\u5ea6\uff0cCRISPR\u5feb\u901f\u8bca\u65ad\u7cfb\u7edf\u7b49\u65b0\u4e00\u4ee3\u4ea7\u54c1\u4e5f\u88ab\u7528\u4e8e\u5f00\u62d3\u9ad8\u7aef\u5e02\u573a\u3002\u5e02\u573a\u4e0a\u6bd4\u8f83\u6709\u4ee3\u8868\u6027\u7684CRISPR\u5feb\u901f\u8bca\u65ad\u5382\u5546\uff08\u548c\u4ea7\u54c1\uff09\u5305\u62ec Sherlock Bioscience\u3001Proof diagnostic\u3001\u5410\u9732\u6e2f\u751f\u7269\u7684HOLMESv2\u7cfb\u7edf\u3001Mammoth Biosciences \u7684DETECTR\u8bca\u65ad\u7cfb\u7edf\u3001\u4e3a\u771f\u751f\u7269\u7684NuRapid\u5206\u5b50\u68c0\u6d4b\u6280\u672f\u5e73\u53f0\u7b49\u3002<\/p>\n<\/p>\n<p>\u57fa\u56e0\u6167\u8ba4\u4e3a\uff0c\u5728\u5206\u5b50\u9176\u9886\u57df\u53ef\u4ee5\u5173\u6ce8\u7684\u65b9\u5411\u5305\u62ec\uff1a<\/p>\n<p>\u8bca\u65ad\u9176\u7684\u6027\u80fd\u63d0\u5347\u53ca\u751f\u4ea7\u5de5\u827a\u4f18\u5316\uff1b<\/p>\n<p>\u5408\u6210\u751f\u7269\u76f8\u5173\u5206\u5b50\u9176\u7684\u4ea7\u54c1\u7814\u53d1\uff1b<\/p>\n<p>POCT\uff08Point of Care Testing\uff0c\u5373\u65f6\u68c0\u6d4b\uff09\u8bd5\u5242\u548c\u8bbe\u5907\u7684\u8fed\u4ee3\uff1b<\/p>\n<p>CRISPR\u5feb\u901f\u8bca\u65ad\u4ea7\u54c1\u7684\u51c6\u5165\u53ca\u9002\u7528\u8303\u56f4\u6269\u5c55\u7b49\u3002<\/p>\n<\/p>\n<p>02\u4ece\u5355\u4e2a\u7ec6\u80de\u5206\u8fa8\u7387\u89e3\u7801\u751f\u547d<\/p>\n<p>\u5355\u7ec6\u80de\u5206\u6790\u7cfb\u7edf<\/p>\n<p>\u901a\u5e38\u7684\u6d4b\u5e8f\u6280\u672f\u7814\u7a76\u7ec6\u80de\u7fa4\u4f53\u7684\u5e73\u5747\u7279\u5f81\uff0c\u8fd9\u65e0\u6cd5\u6ee1\u8db3\u4e2a\u522b\u60c5\u51b5\u4e0b\u5728\u5355\u4e2a\u7ec6\u80de\u5c42\u9762\u7814\u7a76\u7684\u9700\u6c42\uff08\u4f8b\u5982\u80bf\u7624\u7ec6\u80de\u7684\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\uff09\u3002\u5355\u7ec6\u80de\u5206\u6790\u6280\u672f\u57282009\u5e74\u524d\u540e\u5e94\u666f\u51fa\u73b0\u3002<\/p>\n<\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgB5W5ICbmuwpHobBBEsfUyPeVkLg0iaYAFdLpgjjWTqnjP5RRklcFGsMBic9U4I5adTOzuwUzh8Ifww.png\" alt=\"RmFicvQBAkgB5W5ICbmuwpHobBBEsfUyPeVkLg0iaYAFdLpgjjWTqnjP5RRklcFGsMBic9U4I5adTOzuwUzh8Ifww\"\/><\/figure><\/div>\n\n<\/p>\n<p>\u5355\u7ec6\u80de\u5206\u6790\uff08\u5355\u7ec6\u80de\u6d4b\u5e8f\uff09\uff0c\u672c\u8d28\u4e0a\u662f\u5206\u6790\u5355\u4e2a\u7ec6\u80de\u6c34\u5e73\u7684\u5e8f\u5217\u4fe1\u606f\uff0c\u4ee5\u66f4\u9ad8\u5206\u8fa8\u7387\u63ed\u793a\u7ec6\u80de\u95f4\u7684\u5f02\u8d28\u6027\u4ee5\u53ca\u5176\u5728\u5fae\u73af\u5883\u4e2d\u7684\u53cd\u5e94\u60c5\u51b5\uff0c\u5305\u62ec\u4e0d\u540c\u7684\u7ec6\u80de\u7c7b\u578b\u548c\u7ec6\u80de\u7fa4\u7684\u72ec\u7279\u7a81\u53d8\u3001\u514b\u9686\u8fdb\u5316\u3001\u4fe1\u53f7\u4f20\u5bfc\u3001\u7269\u8d28\u4f20\u9012\u4ee5\u53ca\u73af\u5883\u5e94\u7b54\u7b49\u3002<\/p>\n<\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgB5W5ICbmuwpHobBBEsfUyPokX9dJxFFIk58cYcIvVESZtrxgibamCTFdBk61mcWKFyH6v1NrzNcZw.png\" alt=\"RmFicvQBAkgB5W5ICbmuwpHobBBEsfUyPokX9dJxFFIk58cYcIvVESZtrxgibamCTFdBk61mcWKFyH6v1NrzNcZw\"\/><\/figure><\/div>\n\n<\/p>\n<p>\u4ece\u6280\u672f\u4e0a\uff0c\u76ee\u524d\u7684\u5355\u7ec6\u80de\u5206\u6790\u662f\u5728\u5355\u4e2a\u7ec6\u80de\u6c34\u5e73\u6355\u83b7\uff0c\u7ed3\u5408\u6d4b\u5e8f\uff0c\u5bf9\u5355\u7ec6\u80de\u5c42\u9762\u8fdb\u884c\u751f\u7269\u4fe1\u606f\u7684\u83b7\u53d6\u548c\u5206\u6790\uff0c\u7528\u4e8e\u57fa\u7840\u7814\u7a76\u4ee5\u53ca\u4e34\u5e8a\u8bca\u7597\u3001\u5206\u5b50\u80b2\u79cd\u7b49\u65b9\u9762\u5e94\u7528\u3002\u5b8c\u6574\u7684\u5355\u7ec6\u80de\u5206\u6790\uff08\u4ee5\u5355\u7ec6\u80deRNA-Seq\u4e3a\u4f8b\uff09\u901a\u5e38\u5305\u62ec\u4e94\u4e2a\u6b65\u9aa4\uff1a\uff08a\uff09\u6db2\u6ef4\u6cd5\u6216\u8005\u5fae\u5b54\u6cd5\u7b49\u6355\u83b7\u5355\u4e2a\u7ec6\u80de\uff1b\uff08b\uff09\u63d0\u53d6 RNA\uff0c\u5bf9\u53cd\u8f6c\u5f55\u7684 cDNA \u52a0\u6761\u5f62\u7801\uff08barcode\uff09\u5e76\u6269\u589e\uff1b\uff08c\uff09\u6587\u5e93\u5236\u5907\uff1b\uff08d\uff09\u9ad8\u901a\u91cf\u6d4b\u5e8f\uff1b\uff08e\uff09\u751f\u7269\u4fe1\u606f\u5206\u6790\u548c\u6570\u636e\u53ef\u89c6\u5316\u3002<\/p>\n<\/p>\n<p>\u4ece\u5e94\u7528\u4e0a\uff0c\u5355\u7ec6\u80de\u6280\u672f\u7528\u4e8e\u79d1\u6280\u670d\u52a1\uff0c\u5e94\u7528\u4e8e\u79d1\u7814\u3001\u836f\u7269\u3001\u80b2\u79cd\u3001\u5408\u6210\u751f\u7269\u7b49\u65b9\u9762\u3002<\/p>\n<\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgB5W5ICbmuwpHobBBEsfUyPhmG47ljH0mlp7883VTO2HG2WMoCsiay3CaDNpYCVPMf76vQftsRom1g.png\" alt=\"RmFicvQBAkgB5W5ICbmuwpHobBBEsfUyPhmG47ljH0mlp7883VTO2HG2WMoCsiay3CaDNpYCVPMf76vQftsRom1g\"\/><\/figure><\/div>\n\n<\/p>\n<p>\u8fd1\u5e74\uff0c\u5fae\u751f\u7269\u5355\u7ec6\u80de\u6d4b\u5e8f\u5feb\u901f\u53d1\u5c55\uff0c\u5728\u57fa\u7840\u79d1\u7814\uff08\u5fae\u751f\u7269\u7ec4\uff09\u3001\u519c\u4e1a\u751f\u7269\u6280\u672f\uff08\u751f\u7269\u56fa\u6c2e\u3001\u5fae\u751f\u7269\u5236\u5242\u9972\u6599\u7b49\uff09\u3001\u836f\u7269\u7814\u53d1\uff08\u83cc\u682a\u5e93\u3001\u6297\u83cc\u836f\u8010\u836f\u7814\u7a76\u7b49\uff09\u7b49\u65b9\u9762\u63d0\u4f9b\u79d1\u6280\u670d\u52a1\u3002\u4ee5\u58a8\u5353\u751f\u7269\u4e3a\u4f8b\uff0c\u9996\u521b\u7684 MobiMicrobe \u6280\u672f\u5c06\u591a\u79cd\u6db2\u6ef4\u5fae\u6d41\u63a7\u548c\u5b9a\u5236\u7684\u751f\u7269\u4fe1\u606f\u5b66\u5206\u6790\u96c6\u6210\uff0c\u4e0d\u9700\u8981\u57f9\u517b\u5373\u53ef\u4ece\u590d\u6742\u5fae\u751f\u7269\u7fa4\u843d\u4e2d\u83b7\u53d6\u4e07\u91cf\u7ea7\u7684\u5355\u7ec6\u80de\u5fae\u751f\u7269\u7684\u57fa\u56e0\u7ec4\u4fe1\u606f\uff0c\u5e76\u7ec4\u88c5\u51fa\u9ad8\u8d28\u91cf\u7684\u83cc\u682a\u6c34\u5e73\u57fa\u56e0\u7ec4\u30022022\u5e74\uff0c\u4e2d\u56fd\u519c\u4e1a\u5927\u5b66\u738b\u6d9b\u6559\u6388\u3001\u8463\u6c5f\u4e3d\u6559\u6388\u56e2\u961f\u901a\u8fc7\u5355\u7ec6\u80de\u6280\u672f\u63cf\u7ed8\u4e0d\u5b9a\u578b\u6839\u7624\u7684\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u56fe\u8c31\uff0c\u53d1\u73b0\u4e86\u5171\u751f\u56fa\u6c2e\u65b0\u673a\u5236\uff1b\u6155\u6069\u751f\u7269\u57fa\u4e8e\u5355\u7ec6\u80de\u5c42\u9762\u5bf9\u5fae\u751f\u7269\u8fdb\u884c\u5206\u79bb\u57f9\u517b\uff0c\u62e5\u670914\u4e07\u682a\u529f\u80fd\u83cc\u682a\uff0c5\u8f6e\u5171\u8ba1\u6570\u4ebf\u5143\u878d\u8d44\u3002<\/p>\n<\/p>\n<p>\u5355\u7ec6\u80de\u5206\u6790\u7684\u96be\u70b9\u53ca\u6280\u672f\u7a81\u7834\u8def\u7ebf\uff1a<\/p>\n<\/p>\n<p>\u5355\u4e2a\u7ec6\u80de\u6355\u83b7\u7684\u901a\u91cf\uff1a\u968f\u7740Drop-Seq\u6280\u672f\u53ca\u5176\u5546\u4e1a\u5316\u5e73\u53f02017\u5e74\u6210\u719f\u4ee5\u6765\uff0c\u5c06\u5355\u7ec6\u80de\u901a\u91cf\u4ece100\u91cf\u7ea7\u63d0\u9ad8\u81f310000\u91cf\u7ea7\uff0c\u6781\u5927\u964d\u4f4e\u7814\u7a76\u6210\u672c\uff0c\u672a\u6765\u5e02\u573a\u666e\u53ca\u9700\u8fdb\u4e00\u6b65\u63d0\u9ad8\u901a\u91cf\uff1b<\/p>\n<\/p>\n<p>\u7a00\u6709\u7ec6\u80de\u6355\u83b7\u6548\u7387\uff1a\u5360\u6bd40.1%\u4ee5\u4e0b\u7684\u7a00\u6709\u7ec6\u80de\u5f88\u96be\u5206\u9009\u3002\u4ee3\u8868\u6027\u7684\u516c\u53f8\u662fNamocell\u516c\u53f8\uff0c2022\u5e747\u6708\u88ab Bio-Techne \u516c\u53f8\u6536\u8d2d\u3002<\/p>\n<\/p>\n<p>\u6838\u9178\u6269\u589e\uff1a\u5355\u7ec6\u80de\u6d4b\u5e8f\u6700\u5927\u7684\u5c40\u9650\u6027\u5728\u4e8e\u5f85\u6d4b\u6838\u9178\u7684\u542b\u91cf\u6781\u4f4e\uff08pg\u7ea7\uff09\uff0c\u4e14\u6355\u83b7\u6548\u7387\u4f4e\uff08\u7ea610%\uff09\uff0c\u8fbe\u4e0d\u5230\u5efa\u5e93\u8d77\u59cb\u91cf\uff0c\u9700\u6269\u589e\u5355\u7ec6\u80de\u5185\u7684\u5fae\u91cf\u6838\u9178\uff0c\u5982\u4f55\u51cf\u5c11\u6280\u672f\u8bef\u5dee\u662f\u5173\u952e\u3002<\/p>\n<\/p>\n<p>2019\u5e74\u8d77\uff0c\u6211\u56fd\u5355\u7ec6\u80de\u5206\u6790\u9886\u57df\u5f00\u59cb\u52a0\u901f\u53d1\u5c55\uff0c\u4e3b\u8981\u5305\u62ec\u4ee5\u767e\u5965\u667a\u6c47\u4e3a\u4ee3\u8868\u7684\u5355\u7ec6\u80de\u6570\u636e\u5e93\u5e73\u53f0\uff0c\u4ee5\u534e\u5927\u667a\u9020\u3001\u58a8\u5353\u751f\u7269\u4e3a\u4ee3\u8868\u7684\u5355\u7ec6\u80de\u6355\u83b7\u5efa\u5e93\u7cfb\u7edf\u7684\u56fd\u4ea7\u66ff\u4ee3\uff0c\u4ee5\u6d5a\u60e0\u751f\u7269\u4e3a\u4ee3\u8868\u7684\u5355\u7ec6\u80de\u56fe\u50cf\u5206\u6790\u548c\u81ea\u52a8\u5206\u79bb\u4ea7\u54c1\u3002\u5176\u4e2d\u6211\u56fd\u5177\u6709\u56fd\u9645\u5f71\u54cd\u529b\u7684\u6210\u679c\u662f\uff0c\u534e\u5927\u7684 Stereo-SEQ\u6280\u672f\u57fa\u4e8e\u5177\u6709\u7a7a\u95f4\u4f4d\u7f6e\u4fe1\u606f\u7684DNA\u7eb3\u7c73\u7403\u7a7a\u95f4\u6355\u83b7\u82af\u7247\u5b9e\u73b0\u5206\u8fa8\u7387500nm\u7684\u65f6\u7a7a\u56fe\u8c31\uff1b\u58a8\u5353\u5fae\u751f\u7269\u5355\u7ec6\u83cc\u5e73\u53f0MobiNova\u00ae-M1\u5f15\u9886\u5168\u7403\uff0c\u5f00\u542f\u5fae\u751f\u7269\u7684\u5355\u7ec6\u80de\u57fa\u56e0\u7ec4\u65f6\u4ee3\u3002<\/p>\n<\/p>\n<p>\u5176\u4e2d\u5355\u7ec6\u80de\u6355\u83b7\u5efa\u5e93\u7cfb\u7edf\uff0c\u5305\u62ec\u6db2\u6ef4\u6cd5\uff08\u534e\u5927\u667a\u9020\u3001\u58a8\u5353\u751f\u7269\u3001\u5bfb\u56e0\u751f\u7269\u3001\u4e07\u4e58\u57fa\u56e0\u7b49\uff09\u53ca\u5fae\u5b54\u6cd5\uff08\u65b0\u683c\u5143\u3001\u5fb7\u8fd0\u5eb7\u745e\u7b49\uff09\u30022019\u5e74\uff0c\u534e\u5927\u667a\u9020\u63a8\u51fa\u53e3\u888b\u5355\u7ec6\u80de\u5206\u6790\u7cfb\u7edfDNBelab C4\uff0c\u6781\u5927\u964d\u4f4e\u4e86\u5355\u7ec6\u80de\u7814\u7a76\u7684\u95e8\u69db\uff1b2022\u5e74\uff0c\u58a8\u5353\u751f\u7269\u53d1\u5e03 MobiNova \u9ad8\u901a\u91cf\u5355\u7ec6\u80de\u591a\u7ec4\u5b66\u89e3\u51b3\u65b9\u6848\uff0c\u901a\u8fc7\u7a33\u5b9a\u7684\u4ea7\u54c1\u8d28\u91cf\u3001ChIP-seq \u4e3a\u4ee3\u8868\u7684\u521b\u65b0\u7ec4\u5b66\uff0c\u8fc5\u901f\u5728\u79d1\u7814\u670d\u52a1\u5e02\u573a\u5f62\u6210\u66ff\u4ee3\u3002<\/p>\n<\/p>\n<p>\u5355\u7ec6\u80de\u7684\u6280\u672f\u3001\u4ea7\u54c1\u6b63\u5feb\u901f\u53d1\u5c55\uff0c\u5df2\u72ec\u7acb\u6210\u4e00\u4e2a\u89c4\u6a21\u5316\u4ea7\u4e1a\u3002\u672a\u6765\u53ef\u5173\u6ce8\u5982\u4e0b\u65b9\u5411\uff1a<\/p>\n<\/p>\n<p>\u56fd\u4ea7\u5316\u8bbe\u5907\u66ff\u4ee3\u548c\u6210\u672c\u4f18\u5316\uff0c\u80da\u80ce\u690d\u5165\u524d\u5355\u7ec6\u80de\u68c0\u6d4b\u7b49\u8bd5\u5242\u7684\u51c6\u5165\u7b49\uff1b<\/p>\n<p>\u4ece\u5355\u7ec6\u80de\u7a7a\u95f4\u7ec4\u5b66\u548c\u65f6\u7a7a\u7ec4\u5b66\u7684\u8fdb\u4e00\u6b65\u8f6c\u5316\u5e94\u7528\uff1b\u00a0<\/p>\n<p>\u5355\u7ec6\u80de\u8868\u89c2\u9057\u4f20\u5b66\uff08ChIP-seq\uff09\u3001\u8868\u9762\u86cb\u767d\u6d4b\u5e8f\u7b49\u65b0\u5174\u79d1\u7814\u670d\u52a1\uff1b<\/p>\n<p>\u901a\u8fc7\u5355\u7ec6\u80de\u5fae\u751f\u7269\u6d4b\u5e8f\u7b49\u6280\u672f\u6316\u6398\u5fae\u751f\u7269\u83cc\u682a\u53ca\u529f\u80fd\u57fa\u56e0\uff0c\u52a0\u901f\u5408\u6210\u751f\u7269\u7b49\u5e02\u573a\u5e94\u7528\u3002<\/p>\n<\/p>\n<p>03\u57fa\u56e0\u884c\u4e1a\u57fa\u7840\u6280\u672f<\/p>\n<p>\u57fa\u56e0\u6d4b\u5e8f\u53ca\u751f\u4ea7\u5e73\u53f0<\/p>\n<p>\u6d4b\u5e8f\u6280\u672f\u662f\u76ee\u524d\u57fa\u56e0\u884c\u4e1a\u7684\u57fa\u7840\u6280\u672f\uff0c\u6781\u5927\u63a8\u52a8\u4e86\u57fa\u56e0\u884c\u4e1a\u7684\u5e94\u7528\u3002\u6d4b\u5e8f\u672c\u8d28\u662f\u68c0\u6d4b\u57fa\u56e0\u5e8f\u5217\u4fe1\u606f\uff0c\u4e5f\u662f\u57fa\u56e0\u7f16\u8f91\u3001\u57fa\u56e0\u5408\u6210\u8fc7\u7a0b\u4e2d\u7684\u57fa\u7840\u6280\u672f\u3002<\/p>\n<\/p>\n<p>\u5b9e\u73b0\u68c0\u6d4b\u57fa\u56e0\u5e8f\u5217\u529f\u80fd\u7684\u6280\u672f\uff0c\u8fd8\u5305\u62ec\u57fa\u56e0\u82af\u7247\u3001\u8367\u5149\u5b9a\u91cfPCR\u3001\u6570\u5b57PCR\u3001\u5149\u5b66\u56fe\u8c31\u3001\u6838\u9178\u8d28\u8c31\u7b49\uff08\u6ce8\uff1a\u7531\u4e8e\u6d4b\u5e8f\u7684\u901a\u7528\u6027\u4ee5\u53ca\u672a\u6765\u6269\u5c55\u6027\uff0c\u6b64\u5904\u5bf9\u6b64\u5c55\u5f00\u91cd\u70b9\u8ba8\u8bba\uff09\u3002<\/p>\n<\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgB5W5ICbmuwpHobBBEsfUyPKuDcXkoO0no6N6QoFThwWJe6wfTVjaZmx5HMvmqsHLs9FMMaPkchyw.png\" alt=\"RmFicvQBAkgB5W5ICbmuwpHobBBEsfUyPKuDcXkoO0no6N6QoFThwWJe6wfTVjaZmx5HMvmqsHLs9FMMaPkchyw\"\/><\/figure><\/div>\n\n<\/p>\n<p>\u7406\u89e3\u6280\u672f\u539f\u7406\u662f\u8bc4\u4f30\u4e0d\u540c\u6d4b\u5e8f\u7cfb\u7edf\u7684\u57fa\u7840\u3002\u8fd9\u91cc\u5bf9\u4e0d\u540c\u6d4b\u5e8f\u6280\u672f\u539f\u7406\u4f5c\u7b80\u8981\u9610\u8ff0\u3002<\/p>\n<\/p>\n<p>1975\u5e74\uff0cSanger\u6d4b\u5e8f\u6cd5\u5728\u5434\u745e\u5148\u751f\u7684\u5f15\u7269\u5ef6\u4f38\u7684\u57fa\u7840\u4e0a\u5b9e\u73b0\u4e86\u201c\u76f4\u8bfb\u201d\u2014\u2014\u901a\u8fc7\u5b9e\u73b0DNA\u590d\u5236\u53ca\u5408\u6210\uff0c\u76f4\u63a5\u5728\u51dd\u80f6\u4e0a\u6309\u987a\u5e8f\u76f4\u89c2\u8bfb\u51fa\u6d4b\u5e8f\u6a21\u677f\u3002\u5177\u4f53\u5730\uff0c\u5373\u5728DNA\u94fe\u5408\u6210\u8fc7\u7a0b\u4e2d\u52a0\u5165\u53cc\u8131\u6c27\u6838\u82f7\u9178\uff08ddNTP\uff09\uff0c\u8367\u5149\u6807\u8bb0\u7684ddNTP\u548c\u5929\u7136\u78b1\u57fa\uff08\u5355\u8131\u6c27\u6838\u82f7\u9178dNTP\uff09\u6309\u78b1\u57fa\u4e92\u8865\u7684\u539f\u5219\u88ab\u805a\u5408\u5230\u65b0\u5408\u6210\u7684DNA\u94fe\u4e0a\uff1b\u5f53\u805a\u5408\u5230ddNTP\uff0cDNA \u94fe\u5408\u6210\u5c31\u7ec8\u6b62\uff08\u201c\u53cc\u8131\u6c27\u94fe\u672b\u7aef\u5408\u6210\u7ec8\u6b62\u6cd5\u201d\u7684\u7531\u6765\uff09\uff1b\u8367\u5149\u4fe1\u53f7\u88ab\u6210\u50cf\u7cfb\u7edf\u68c0\u6d4b\u5e76\u7ed3\u5408\u51dd\u80f6\u7535\u6cf3\u4e0a\u7684\u4f4d\u7f6e\uff0c\u5373\u786e\u5b9a\u5f85\u6d4bDNA\u5e8f\u5217\u3002\u8fd9\u4e5f\u662f\u6700\u4f20\u7edf\u7684\u8fb9\u5408\u6210\u8fb9\u6d4b\u5e8f\u6280\u672f\uff08Sequencing by Synthesis\uff0cSBS\uff09\u3002<\/p>\n<\/p>\n<p>1986 \u5e74\uff0c\u52a0\u5dde\u7406\u5de5\u5b66\u9662\u7684Leroy Hood\u53d1\u660e\u4e86\u201c\u56db\u8272\u8367\u5149\u6cd5\u201d\uff0c\u4f7f\u5f97\u4f20\u7edf\u7684SBS\u8d70\u5411\u81ea\u52a8\u5316\uff08ABI\u6d4b\u5e8f\u7cfb\u7edf\uff09\uff1b\u4ece454\u7cfb\u7edf\u5f00\u59cb\uff0c\u5f15\u5165\u4e86\u53ef\u9006\u7ec8\u6b62\u672b\u7aef\uff0c\u5efa\u7acb\u7126\u78f7\u9178\u6d4b\u5e8f\uff0c\u5b9e\u73b0\u9ad8\u901a\u91cf\u6d4b\u5e8f\u7684NGS\uff0c\u5373\u901a\u8fc7\u8bfb\u53d6dNPT\u5728DNA\u805a\u5408\u53cd\u5e94\u65f6\u91ca\u653e\u51fa\u7684\u7126\u78f7\u9178\uff0c\u91c7\u7528\u4e73\u6db2PCR\u6765\u6784\u5efa\u6587\u5e93\uff1bIon Torrent \u6d4b\u5e8f\u662f\u57fa\u4e8e\u534a\u5bfc\u4f53\u5143\u4ef6\uff0c\u68c0\u6d4b\u6d4b\u5e8f\u53cd\u5e94\u8fc7\u7a0b\u4e2d H+ \u6d53\u5ea6\u53d8\u5316\uff0c\u56e0\u4e3a\u8bbe\u8ba1\u5de7\u5999\u800c\u4f53\u79ef\u5c0f\uff0c\u6210\u4e3a\u7b2c\u4e00\u4ee3\u684c\u9762\u578b\u6d4b\u5e8f\u4eea\u4ee3\u8868\uff1bIllumina \u6d4b\u5e8f\u662f\u57fa\u4e8e\u53ef\u9006\u7ec8\u6b62\u6cd5\uff0c\u901a\u8fc7 3&#8242; \u7aef\u53ef\u9006\u6027\u7684\u4fee\u9970\u548c\u53bb\u4fee\u9970\u5b9e\u73b0\u672b\u7aef\u5faa\u73af\u5408\u6210\u6d4b\u5e8f\uff0c\u91c7\u7528DNA\u6a21\u677f\u5206\u5b50\u7c07\u5408\u6210DNA\u7a81\u7834\u6027\u5730\u6269\u5927\u4e86\u901a\u91cf\uff1bSOLiD \u6d4b\u5e8f\u662f\u8fde\u63a5\u6d4b\u5e8f\u6cd5\uff0c\u7279\u522b\u4e4b\u5904\u662f\u4ee5DNA\u8fde\u63a5\u9176\u53d6\u4ee3DNA\u805a\u5408\u9176\uff0c\u5bf9\u6bcf\u4e2a\u78b1\u57fa\u8bfb\u4e24\u6b21\uff0c\u7406\u8bba\u4e0a\u63d0\u9ad8\u51c6\u786e\u7387\uff1b\u534e\u5927\u667a\u9020\u7684 DNBSEQ \u91c7\u7528\u4f18\u5316\u7684\u8054\u5408\u63a2\u9488\u951a\u5b9a\u805a\u5408\u6280\u672f\uff08cPAS\uff09\u548c\u6539\u8fdb\u7684DNA\u7eb3\u7c73\u7403\uff08DNB\uff09\uff0c\u901a\u8fc7\u7ebf\u6027\u6269\u589e\u964d\u4f4e\u5355\u62f7\u8d1d\u7684\u9519\u8bef\u7387\u3002<\/p>\n<\/p>\n<p>\u5355\u5206\u5b50\u6d4b\u5e8f\u662f\u901a\u8fc7\u5355\u5206\u5b50\u7684\u68c0\u6d4b\u88c5\u7f6e\u76f4\u63a5\u8bfb\u53d6\u78b1\u57fa\uff0c\u6700\u5927\u7279\u70b9\u662f\u65e0\u9700PCR\u6269\u589e\uff0c\u51cf\u5c11\u6269\u589e\u4e2d\u7684\u504f\u53f7\uff08bias\uff09\u4e14\u63d0\u9ad8\u8bfb\u957f\u3002\u5177\u6709\u4ee3\u8868\u6027\u7684\u4f01\u4e1a\u4e4b\u4e00\u662f HeliScope\uff0c\u672c\u8d28\u662f\u5728SBS\u52a0\u4e0a\u8d85\u654f\u611f\u7684\u8367\u5149\u68c0\u6d4b\u88c5\u7f6e\uff0c\u76f8\u5173\u6280\u672f\u540e\u6765\u88ab\u90e8\u5206\u516c\u53f8\u5f15\u5165\uff1bPacBio\u7684\u6838\u5fc3\u662f\u96f6\u819c\u6ce2\u5bfc\u5b54\uff0c\u6bcf\u4e2a\u5355\u5143\u767e\u4e07\u7ea7\u6570\u91cf\u7684\u5b54\u4e0a\u56fa\u5b9aDNA\u94fe\u53cadNTP\uff0c\u7ed3\u5408\u65f6\u88ab\u6fc0\u5149\u7167\u5c04\u53d1\u51fa\u8367\u5149\u7136\u540e\u8f6c\u6362\u6210\u78b1\u57fa\u4fe1\u53f7\uff1bONT\u7684\u7eb3\u7c73\u5b54\u6d4b\u5e8f\u662f\u5355\u5206\u5b50\u6d4b\u5e8f\u7684\u4e00\u79cd\uff0c\u901a\u8fc7\u5355\u94feDNA\u6216RNA\u901a\u8fc7\u7eb3\u7c73\u5b54\u65f6\u7684\u7535\u4fe1\u53f7\u5b9e\u65f6\u6d4b\u5e8f\u3002\u7eb3\u7c73\u5b54\u5305\u62ec\u7269\u7406\u7eb3\u7c73\u5b54\uff08\u7845\u7b49\u65e0\u673a\u6750\u6599\uff09\u548c\u751f\u7269\u7eb3\u7c73\u5b54\uff08\u7eb3\u7c73\u82af\u7247\u4e0a\u7684\u86cb\u767d\u8d28\uff09\u3002<\/p>\n<\/p>\n<p>\u6d4b\u5e8f\u6280\u672f\u7ecf\u5386\u4e86\u8fd150\u5e74\u7684\u53d1\u5c55\uff0c\u7b2c\u4e00\u53f0\u5546\u7528\u6d4b\u5e8f\u4eea Prism370A \u9762\u4e16\u4e8637\u5e74\uff0c\u4f46\u771f\u6b63\u7684\u5927\u89c4\u6a21\u5546\u7528\u5316\u4ec517\u5e74\uff08\u8d77\u70b9\u662f2008\u5e74GAII\u5c06WGS\u964d\u4f4e\u81f310\u4e07\u7f8e\u5143\uff09\uff0c\u771f\u6b63\u7684\u767e\u7f8e\u5143\u57fa\u56e0\u7ec4\u624d\u521a\u521a\u5f00\u59cb\uff082023\u5e74\u534e\u5927\u667a\u9020\u53d1\u5e03 DNBSEQ-T20x2\uff09\uff0c\u771f\u6b63\u7684\u666e\u60e0\u65f6\u4ee3\u5373\u5c06\u5230\u6765\uff1b2022\u5e74\u524d\u540e\uff0c\u5e02\u573a\u4e0a\u4ee5\u201c\u8236\u6765\u201d\u7684\u4e13\u5229\u63a8\u51fa\u6570\u79cd\u6d4b\u5e8f\u4eea\u65b0\u54c1\u6d8c\u73b0\uff0c\u9700\u8981\u8c28\u614e\u8bc4\u4f30\u6280\u672f\u539f\u521b\u6027\u53ca\u5e94\u7528\u53ef\u53ca\u6027\uff0c\u4f01\u4e1a\u9700\u8981\u91cd\u89c6\u5e95\u5c42\u6280\u672f\u7814\u53d1\u548c\u4ea7\u54c1\u4e0a\u5e02\u524d\u7684\u9a8c\u8bc1\u5de5\u4f5c\u3002<\/p>\n<\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgB5W5ICbmuwpHobBBEsfUyPHlEibica4RjfE1rkI6VJcOl97OdeAibKFCQQiafWNNP3kuhaI2cc6HibLcg.png\" alt=\"RmFicvQBAkgB5W5ICbmuwpHobBBEsfUyPHlEibica4RjfE1rkI6VJcOl97OdeAibKFCQQiafWNNP3kuhaI2cc6HibLcg\"\/><\/figure><\/div>\n\n<p>\u76ee\u524d 454 \u6d4b\u5e8f\u4eea\uff08\u7126\u78f7\u9178\u6d4b\u5e8f\u6cd5\uff09\uff0cSOLiD\uff08\u8fde\u63a5\u6cd5\u6d4b\u5e8f\uff09\u3001HeliScope \u5747\u9000\u51fa\u4e86\u5e02\u573a\u3002\u6309\u8fdb\u5165\u5e02\u573a\u7684\u65f6\u95f4\u987a\u5e8f\uff0c\u76ee\u524d\u5e02\u9762\u4e0a\u4e3b\u6d41\u6d4b\u5e8f\u6280\u672f\u53ca\u54c1\u724c\u5982\u4e0b\uff1a<\/p>\n<ul>\n<li>\u53ef\u9006\u672b\u7aef\u7ec8\u6b62\u6d4b\u5e8f\u6cd5\uff08\u4ee5\u00a0Solexa\u00a0\u6d4b\u5e8f\u6280\u672f\u4e3a\u57fa\u7840\u7684\u00a0Illumina\u00a0\u6d4b\u5e8f\u4eea\u7cfb\u5217\uff09<\/li>\n<li>\u534a\u5bfc\u4f53\u6d4b\u5e8f\u6cd5\uff08Ion Torrent\u00a0\u7cfb\u5217\u6d4b\u5e8f\u4eea\uff0c2010\u00a0\u5e74\u88ab\u00a0Life Technologies\u00a0\u6536\u8d2d\uff09<\/li>\n<li>\u5355\u5206\u5b50\u8367\u5149\u6d4b\u5e8f\uff08\u4ee5\u96f6\u819c\u6ce2\u5bfc\u5b54\u548c\u8367\u5149\u4fe1\u53f7\u4e3a\u6838\u5fc3\u7684\u00a0PacBio\u00a0\u6d4b\u5e8f\u4eea\u7cfb\u5217\uff09<\/li>\n<li>\u5355\u5206\u5b50\u7eb3\u7c73\u5b54\u6d4b\u5e8f\uff08\u4ee5\u7eb3\u7c73\u5b54\u86cb\u767d\u548c\u7535\u4fe1\u53f7\u4e3a\u6838\u5fc3\u7684\u00a0ONT\u3001\u9f50\u78b3\u79d1\u6280\u6d4b\u5e8f\u4eea\u7cfb\u5217\uff09<\/li>\n<li>\u8054\u5408\u63a2\u9488\u951a\u5b9a\u805a\u5408\u6d4b\u5e8f\u6cd5\uff08\u4ee5\u00a0DNBSEQ\u00a0\u6d4b\u5e8f\u6280\u672f\u4e3a\u6838\u5fc3\u7684\u534e\u5927\u667a\u9020\u6d4b\u5e8f\u4eea\u7cfb\u5217\uff09<\/li>\n<li>\u4eb2\u548c\u529b\u6d4b\u5e8f\u6cd5\uff08\u4ee5\u00a0AVITI\u00a0\u6d4b\u5e8f\u6280\u672f\u4e3a\u6838\u5fc3\u7684\u5143\u7d20\u751f\u7269\u6d4b\u5e8f\u4eea\u7cfb\u5217\uff09<\/li>\n<\/ul>\n<p>\u4ece\u6d4b\u5e8f\u539f\u7406\u548c\u5de5\u5177\u4e0a\uff0c\u5e02\u9762\u4e0a\u4fd7\u79f0\u201c\u4e00\u4ee3\u201d\u3001\u201c\u4e8c\u4ee3\u201d\u53ca\u201c\u4e09\u4ee3\u201d \uff1b\u4f46\u4ece\u5e94\u7528\u4e0a\uff0c\u76ee\u524d\u4e00\u4ee3\u6d4b\u5e8f\u4e3a\u91d1\u6807\u51c6\uff0c\u4e8c\u4ee3\u6d4b\u5e8f\u548c\u4e09\u4ee3\u6d4b\u5e8f\u5206\u522b\u5728\u77ed\u8bfb\u957f\u548c\u957f\u8bfb\u957f\u4e0a\u5404\u6709\u4f18\u52bf\uff0c\u4e92\u4e3a\u8865\u5145\u3002<\/p>\n<p>\u4f34\u968f\u5236\u9020\u4e1a\u53ca\u56fd\u4ea7\u5316\u7ea2\u5229\uff082022\u5e74\u533b\u7597\u8bbe\u5907\u66f4\u65b0\u6539\u9020\u8d34\u606f\u8d37\u6b3e2000\u4ebf\uff09\uff0c\u6d4b\u5e8f\u4eea\u7684\u5e02\u573a\u4f30\u503c\u7ef4\u6301\u9ad8\u589e\u957f\uff0c\u53ef\u5173\u6ce8\u534e\u5927\u667a\u9020\u3001\u9f50\u78b3\u79d1\u6280\u3001\u5b89\u5e8f\u6e90\u3001\u8d5b\u7eb3\u751f\u7269\u3001\u94ed\u6bc5\u667a\u9020\u7b49\u3002\u57282022\u5e74\uff0c\u534e\u5927\u667a\u9020\u5728\u56fd\u5185\u57fa\u56e0\u6d4b\u5e8f\u8bbe\u5907\u5e02\u573a\u4efd\u989d 39%\uff0c\u6d4b\u5e8f\u4eea\u6536\u5165\u540c\u6bd4\u589e\u957f37.74%\uff1b\u57282023\u5e74Q1\uff0c\u534e\u5927\u667a\u9020\u63a8\u51fa\u4e86\u8d85\u9ad8\u901a\u91cf\u57fa\u56e0\u6d4b\u5e8f\u4eeaDNBSEQ-T20\u00d72\uff0c\u5355\u673a\u5e74\u4ea7\u91cf\u9ad8\u8fbe5\u4e07WGS \u53ca\u4ee5\u4e0a\u3001\u5355\u6837\u672c\u6d4b\u5e8f\u6210\u672c\u4f4e\u4e8e\u767e\u7f8e\u5143\uff0c\u6d4b\u5e8f\u4eea\u4e1a\u52a1\u5ef6\u7eed\u589e\u957f\u6001\u52bf\uff0c\u6574\u4f53\u6536\u5165\u540c\u6bd4\u589e\u957f12%\u3002\u503c\u5f97\u5173\u6ce8\u7684\u662f\uff0cElement Bio\u53d1\u5e03\u4e2d\u901a\u91cf\u3001\u9ad8\u7075\u6d3b\u5ea6\u6d4b\u5e8f\u4eea\uff0c2022\u5e7412\u6708\u6b63\u5f0f\u5ba3\u5e03\u6210\u7acb\u4e2d\u56fd\u4ee3\u8868\u5904\uff08\u5143\u7d20\u751f\u7269\u79d1\u5b66\u516c\u53f8\uff09\uff1bPacBio \u63a8\u51fa1000\u7f8e HiFi\u4eba\u5168\u57fa\u56e0\u7ec4\u7684\u957f\u8bfb\u957f\u6d4b\u5e8f\u7cfb\u7edf Revio\uff0c\u5168\u5e74\u8425\u65361.28 \u4ebf\u7f8e\u5143\uff08\u540c\u6bd4-2%\uff09\uff1bONT\u5168\u5e74\u8425\u65361.99 \u4ebf\u82f1\u9551\uff08\u540c\u6bd4+49%\uff09\uff0c\u9884\u8ba12023\u5e74\u5b9e\u73b0MiniION\u81ea\u52a8\u5316\u548cRNA\u76f4\u63a5\u6d4b\u5e8f\uff0c2026\u5e74\u5b9e\u73b0\u76c8\u4e8f\u5e73\u8861\u3002<\/p>\n<p>04\u00a0\u00a0\u57fa\u56e0\u6cbb\u7597\u4ea7\u4e1a\u5316\u6838\u5fc3<\/p>\n<p>\u57fa\u56e0\u7f16\u8f91\u53ca\u57fa\u56e0\u6cbb\u7597\u8f7d\u4f53<\/p>\n<p>\u5f53\u4e0b\u57fa\u56e0\u6cbb\u7597\u4ea7\u4e1a\u5316\u7684\u6838\u5fc3\u662f\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u4e13\u5229\u53ca\u8f7d\u4f53\u751f\u4ea7\u3002<\/p>\n<p>\u8f7d\u4f53\u4ee5\u75c5\u6bd2\uff08AAV\u7b49\uff09\u6216\u8d28\u7c92DNA\u6700\u4e3a\u5e38\u89c1\u3002\u6700\u5e38\u7528\u7684\u75c5\u6bd2\u8f7d\u4f53\u5305\u62ec\u817a\u76f8\u5173\u75c5\u6bd2\u3001\u817a\u75c5\u6bd2\u3001\u9006\u8f6c\u5f55\u75c5\u6bd2\u3001\u6162\u75c5\u6bd2\u7b49\u3002\u65e9\u57282003\u5e74\uff0c\u6211\u56fd\u6279\u51c6\u7684\u5168\u7403\u9996\u4e2a\u57fa\u56e0\u6cbb\u7597\u836f\u7269\uff0c\u6765\u81ea\u6df1\u5733\u8d5b\u767e\u8bfa\u516c\u53f8\u7684\u201c\u4eca\u53c8\u751f\u201d\u5373\u662f\u91cd\u7ec4\u4ebaP53\u817a\u75c5\u6bd2\u6ce8\u5c04\u6db2\u3002\u75c5\u6bd2\u8f7d\u4f53\u5177\u6709\u7ec4\u7ec7\u55dc\u6027\u548c\u514d\u75ab\u539f\u6027\u7b49\u95ee\u9898\uff0c\u8fd1\u5e74\u975e\u75c5\u6bd2\u8f7d\u4f53\u4e5f\u5728\u5feb\u901f\u53d1\u5c55\u3002\u8f7d\u4f53\u751f\u4ea7\u4f01\u4e1a\u53ef\u5173\u6ce8\u548c\u5143\u751f\u7269\u3001\u836f\u660e\u751f\u57fa\u3001\u535a\u817e\u751f\u7269\u7b49\u3002<\/p>\n<p>\u57fa\u56e0\u7f16\u8f91\u6307\u7684\u662f\u901a\u8fc7\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u5b9e\u73b0\u76ee\u7684\u57fa\u56e0\u7684\u6821\u6b63\u3001\u6572\u9664\u548c\u589e\u52a0\uff0c\u8d77\u6b65\u4e8e20\u4e16\u7eaa\u672b\uff0c\u4ece\u950c\u6307\u6838\u9178\u9176\uff08ZFN\uff09\u3001\u8f6c\u5f55\u6fc0\u6d3b\u5b50\u6837\u6548\u5e94\u56e0\u5b50\u6838\u9178\u9176\uff08TALEN\uff09\u3001CRISPR-Cas9\uff082012\u5e74\uff09\u53d1\u5c55\u5230\u524d\u6cbf\u7684\u78b1\u57fa\u7f16\u8f91\u6280\u672f\uff082016\u5e74\uff09\u7b49\u3002<\/p>\n<p>CRISPR-Cas9 \u7684\u672c\u8d28\u662f\u57fa\u4e8e\u4e00\u4e2a\u77ed\u7684\u56de\u6587\u5e8f\u5217 CRISPR RNA \u7279\u5f81\uff0c\u5229\u7528 Cas9 \u86cb\u767d\u6765\u8bc6\u522b\u3001\u7ed3\u5408\u548c\u5207\u5272\u9776\u5411\u7684 DNA\u30022020\u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u6388\u4e88 CRISPR-Cas9 \u7684\u7814\u7a76\u8005\u52a0\u5dde\u5927\u5b66\u4f2f\u514b\u5229\u5206\u6821\u751f\u7269\u5316\u5b66\u5bb6Jennifer Doudna\uff1b\u540c\u65f6\uff0c2022\u5e742\u6708\uff0c\u7f8e\u56fd\u4e13\u5229\u548c\u5546\u6807\u5c40\uff08USPTO\uff09\u5224\u5b9a\u6765\u81ea\u54c8\u4f5b\u5927\u5b66\u548c\u9ebb\u7701\u7406\u5de5\u5b66\u9662\u535a\u5fb7\u7814\u7a76\u6240\uff08Broad Institute\uff09\u7684\u5f20\u950b\u56e2\u961f\u62e5\u6709\u5728\u771f\u6838\u7ec6\u80de\u4e2d\u4f7f\u7528 CRISPR \u7684\u4e13\u5229\u3002\u672a\u6765\u4ecd\u9700\u8fdb\u4e00\u6b65\u514b\u670d\u8131\u9776\u73b0\u8c61\uff0c\u63d0\u9ad8 Cas9 \u86cb\u767d\u6d3b\u6027\u4ee5\u53ca\u4f20\u9012\u6709\u6548\u6027\u3002<\/p>\n<p>\u4e3a\u4e86\u89e3\u51b3\u5728\u57fa\u56e0\u7f16\u8f91\u8fc7\u7a0b\u4e2d\u66f4\u51c6\u786e\u5730\u627e\u5230\u9776\u70b9\uff0c\u5b8c\u6210\u7cbe\u786e\u7684\u5207\u5272\u548c\u7cbe\u51c6\u7684\u7f16\u8f91\uff0c2016\u5e74\uff0c\u57fa\u56e0\u7f16\u8f91\u9886\u57df\u7684\u53e6\u4e00\u4f4dKOL\u2014\u2014\u6765\u81ea\u54c8\u4f5b\u5927\u5b66\u7684David Liu\u53d1\u660e\u4e86\u5355\u78b1\u57fa\u7f16\u8f91\u5668\uff08Base Editor\uff09\uff0c\u63d0\u5347\u4e86\u57fa\u56e0\u7f16\u8f91\u6548\u7387\uff0c\u964d\u4f4e\u4e86\u8131\u9776\u6548\u5e94\uff0c\u5e76\u4e14\u6301\u7eed\u66f4\u65b0\uff0c\u4ece\u80de\u5627\u5576\u78b1\u57fa\u7f16\u8f91\u5668\uff08CBE\uff0c\u5c06CG \u8f6c\u6362\u4e3aTA\uff09\u3001\u817a\u560c\u5464\u78b1\u57fa\u7f16\u8f91\u5668\uff08ABE\uff0cAT\u8f6c\u6362\u4e3aGC\uff09\u5230 CGBE \u7f16\u8f91\u5668\uff08CG\u8f6c\u6362\u4e3aGC\uff09\u3002Jennifer Doudna\u3001\u5f20\u5cf0\u3001David Liu \u5206\u522b\u521b\u5efa\u4e86 Intellia\u3001Editas\u3001Beam \u7b49\u4f01\u4e1a\u3002<\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgB5W5ICbmuwpHobBBEsfUyPu6tLpEOXgwMH57Jia2CTBYacSzCmZa6zSlaAr7rEjNYIJwNiaSY8egXQ.png\" alt=\"RmFicvQBAkgB5W5ICbmuwpHobBBEsfUyPu6tLpEOXgwMH57Jia2CTBYacSzCmZa6zSlaAr7rEjNYIJwNiaSY8egXQ\"\/><\/figure><\/div>\n\n<\/p>\n<p>\u57fa\u56e0\u6cbb\u7597\u4f01\u4e1a\u805a\u7126\u4e24\u5927\u7c7b\u4e1a\u52a1\uff0c\u5206\u522b\u662f\u8f7d\u4f53\u5de5\u5382\u7684\u7814\u53d1\u751f\u4ea7\u5916\u5305\uff08CDMO\uff09\u6216\u751f\u7269\u6280\u672f\u516c\u53f8\u7684\u5b9e\u9a8c\u5ba4\u670d\u52a1\uff08\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u7814\u53d1\u53ca\u4e34\u5e8a\u524d\u7814\u53d1\u7b49\uff09\u3002<\/p>\n<\/p>\n<p>\u8f7d\u4f53\u7684 CDMO \u7684\u5173\u952e\u56e0\u7d20\u662f\u8d44\u672c\u3002\u5934\u90e8\u673a\u6784\u901a\u8fc7\u4e0a\u5e02\u3001\u878d\u8d44\u3001\u8fdb\u800c\u6536\u8d2d\u7b49\u6269\u5927\u4ea7\u80fd\u7684\u65b9\u5f0f\u6765\u62a2\u5360\u5e02\u573a\u9ad8\u5730\u3002\u5eb7\u9f99\u5316\u6210\u4ee5\u6536\u8d2d\u5f00\u542f\u548c\u52a0\u901f CGT\uff08\u7ec6\u80de\u548c\u57fa\u56e0\u6cbb\u7597\uff09\u4e1a\u52a1\u677f\u5757\u5efa\u8bbe\uff0c2020 \u5e74\u8d77\u5148\u540e\u6536\u8d2d\u7f8e\u56fd\u7684Absorption Systems\u3001\u82f1\u56fd\u7684 Allergan Biologics Limited\uff08\u827e\u4f2f\u7ef4\u65d7\u4e0b\uff09\u548c\u82f1\u56fd\u7684 Pharmaron Biologics(UK) \u7b49\u4f01\u4e1a\uff0c\u5efa\u7acb\u8fd170000\u5e73\u65b9\u7c73GMP\uff0c\u9884\u8ba12023\u5e74\u5f00\u59cb\u627f\u63a5\u9879\u76ee\u3002<\/p>\n<\/p>\n<p>\u4f20\u7edf\u7684CRISPR\u7cfb\u7edf\u5b58\u5728\u7f16\u8f91\u6548\u7387\u4e0e\u7cbe\u51c6\u5ea6\u7684\u5c40\u9650\uff0c\u56e0\u4e3a\u4f53\u79ef\u8fc7\u5927\u4e5f\u7f3a\u4e4f\u5408\u9002\u7684\u9012\u9001\u8f7d\u4f53\u3002\u8fd1\u5e74\uff0c\u78b1\u57fa\u7f16\u8f91\u5668\u7b49\u65b0\u578b\u57fa\u56e0\u7f16\u8f91\u5de5\u5177\u88ab\u9646\u7eed\u5f00\u53d1\u3002<\/p>\n<\/p>\n<div>\u9664\u4e86AAV\u75c5\u6bd2\u8f7d\u4f53\u4e4b\u5916\uff0c\u8102\u8d28\u7eb3\u7c73\u9897\u7c92\uff08LNP\uff09\u3001\u75c5\u6bd2\u6837\u9897\u7c92\uff08VLP\uff09\u3001\u5916\u6ccc\u4f53\uff08\u7ec6\u80de\u5916\u56ca\u6ce1\uff09\u7b49\u975e\u75c5\u6bd2\u8f7d\u4f53\u9012\u9001\u7cfb\u7edf\u4e5f\u53d6\u5f97\u8fdb\u5c55\uff0c\u63a8\u52a8\u57fa\u56e0\u7f16\u8f91\u7597\u6cd5\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\u3002\u4ee5Intellia \u516c\u53f8\u7684\u7ba1\u7ebf\u53d1\u5c55\u4e3a\u4f8b\uff1a<\/div>\n<p>2020\u5e7410\u6708\uff0cIntellia Therapeutics \u516c\u53f8\u7684NTLA-2001\u901a\u8fc7LNP\u88c5\u8f7d\u9776\u5411TTR\u57fa\u56e0\u7684 CRISPR \u57fa\u56e0\u7f16\u8f91\u7cfb\u7edf\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7ed9\u836f\uff0c\u6cbb\u7597\u8f6c\u7532\u72b6\u817a\u7d20\u86cb\u767d\u6dc0\u7c89\u6837\u53d8\u6027\uff08ATTR\uff09\uff0c\u8fd9\u662f\u9996\u6b3e\u901a\u8fc7\u9759\u8109\u6ce8\u5c04\u3001\u5168\u8eab\u7ed9\u836f\u7684\u57fa\u56e0\u7f16\u8f91\u7597\u6cd5\u5019\u9009\u836f\uff1b<\/p>\n<p>2021\u5e746\u6708\uff0cIntellia Therapeutics \u548c\u518d\u751f\u5143\u8054\u5408\u5ba3\u5e03 NTLA-2001\u57281\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u83b7\u5f97\u79ef\u6781\u7ed3\u679c\uff0c\u5177\u6709\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u8bd5\u9a8c\u7ed3\u679c\u53d1\u8868\u5728\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\u3002\u4e34\u5e8a\u6570\u636e\u663e\u793a\uff0c6\u540d\u60a3\u8005\u63a5\u53d7\u6cbb\u759728\u5929\u540e\uff0c\u4e24\u79cd\u4e0d\u540c\u5242\u91cf\uff080.1mg\/kg \u53ca 0.3mg\/kg\uff09\u7684\u60a3\u8005\u8840\u6d46\u4e2dTTR\u86cb\u767d\u6c34\u5e73\u5206\u522b\u5e73\u5747\u4e0b\u964d52%\u548c87%\uff0c\u4e14\u672a\u89c2\u5bdf\u5230\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff1b<\/p>\n<p>2023\u5e743\u6708\uff0cIntellia Therapeutics\u5ba3\u5e03\uff0cFDA\u6279\u51c6\u4e86\u5176\u6cbb\u7597\u9057\u4f20\u6027\u8840\u7ba1\u6027\u6c34\u80bf\uff08HAE\uff09\u7684\u4f53\u5185 CRISPR \u7597\u6cd5 NTLA-2002 \u7684 IND \u7533\u8bf7\u3002\u8fd9\u4e5f\u662f\u9996\u4e2a\u83b7\u5f97 FDA \u6279\u51c6\u7528\u4e8e\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\u7684 LNP \u9012\u9001\u7684\u4f53\u5185 CRISPR \u57fa\u56e0\u7f16\u8f91\u7597\u6cd5\uff1b<\/p>\n<p>\u6b64\u5916\uff0cNTLA-2003\uff08\u6cbb\u7597 \u03b11- \u6297\u80f0\u86cb\u767d\u9176\u7f3a\u4e4f\u6027\u809d\u75c5\uff09\u3001NTLA-3001\uff08\u6cbb\u7597\u03b11-\u6297\u80f0\u86cb\u767d\u9176\u7f3a\u4e4f\u6027\u80ba\u75c5\uff09\u548c\u4e00\u6b3e\u6cbb\u7597\u8840\u53cb\u75c5 B \u578b\u7684\u7597\u6cd5\u6b63\u5728 IND \u7533\u8bf7\uff1b<\/p>\n<p>\u4f53\u5916 CRISPR \u7597\u6cd5\u4e2d\uff0c\u9488\u5bf9\u9570\u72b6\u7ec6\u80de\u75c5\u3001\u6025\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u7684\u7597\u6cd5\u5df2\u5f00\u59cb\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n<\/p>\n<p>\u4ee5\u4f53\u5185\u57fa\u56e0\u7f16\u8f91\u7597\u6cd5\u4e3a\u4f8b\uff0c\u56fd\u5185\u5916\u4ee3\u8868\u4f01\u4e1a\u7684\u76f8\u5173\u8fdb\u5c55\u5982\u4e0b\uff1a<\/p>\n<\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgB5W5ICbmuwpHobBBEsfUyP1urCZENUo5OexgKGZW8xajkgZggVDSFpzYLVoAOo8f4eicC5WrFnWRQ.png\" alt=\"RmFicvQBAkgB5W5ICbmuwpHobBBEsfUyP1urCZENUo5OexgKGZW8xajkgZggVDSFpzYLVoAOo8f4eicC5WrFnWRQ\"\/><\/figure><\/div>\n\n<\/p>\n<p>\u57fa\u56e0\u7f16\u8f91\u7684\u5173\u952e\u662f\u5e95\u5c42\u6280\u672f\u53ca\u5176\u4e13\u5229\u3002\u76ee\u524d\u7edd\u5927\u90e8\u5206\u57fa\u56e0\u7f16\u8f91\u6838\u5fc3\u4e13\u5229\u6765\u81ea\u56fd\u5916\u3002\u6211\u56fd\u5927\u90e8\u5206\u57fa\u56e0\u6cbb\u7597\u4f01\u4e1a\u7ba1\u9053\u662f\u4f53\u5916\u7597\u6cd5\uff08\u57fa\u4e8e\u57fa\u56e0\u7f16\u8f91\u548c\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\uff09\u30022022 \u5e741\u6708\uff0c\u56fd\u5185\u4f01\u4e1a\u8f89\u5927\u57fa\u56e0\u7814\u53d1\u7684 CRISPR-Cas13 RNA \u7f16\u8f91\u5668\u7cfb\u7edf\u7684\u5e95\u5c42\u4e13\u5229\u83b7\u7f8e\u56fd\u4e13\u5229\u5c40\u6388\u6743\uff0c\u662f\u56fd\u5185\u4f01\u4e1a\u7684\u91cc\u7a0b\u7891\uff1b2023\u5e741\u6708\uff0c\u8f89\u5927\u57fa\u56e0\u7684\u57fa\u56e0\u7597\u6cd5 HG004\uff08\u6cbb\u7597 RPE65 \u57fa\u56e0\u7a81\u53d8\u5f15\u8d77\u7684\u76f8\u5173\u6027\u89c6\u7f51\u819c\u75c5\u53d8\uff09\u3001\u5609\u56e0\u751f\u7269\u5ba3\u5e03\u7684\u57fa\u56e0\u7597\u6cd5 EXG102-031 \u6ce8\u5c04\u6db2\uff08\u6cbb\u7597\u6e7f\u6027\u5e74\u9f84\u76f8\u5173\u7684\u9ec4\u6591\u53d8\u6027\uff09\u7684 IND \u88ab FDA \u6279\u51c6\u3002<\/p>\n<\/p>\n<p>FDA \u5bf9\u57fa\u56e0\u6cbb\u7597\u4e34\u5e8a\u8bd5\u9a8c\u5ba1\u6838\u4e25\u683c\uff0c\u9664\u4e86 EDIT-101\uff08\u6cbb\u7597 Leber \u5148\u5929\u6027\u9ed1\u77c7 10\uff09\uff0c\u5bf9\u4e8e eli-cel \u7684 III \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08\u7528\u4e8e\u6cbb\u7597\u8111\u80be\u4e0a\u817a\u8111\u767d\u8d28\u8425\u517b\u4e0d\u826f\uff09\u4e5f\u66fe\u53eb\u505c\u3002\u672a\u6765\uff0c\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u4ecd\u9700\u8fdb\u4e00\u6b65\u6295\u5165\u7814\u53d1\uff0c\u5728\u51cf\u5c11\u8131\u9776\u6548\u5e94\u3001\u63d0\u9ad8\u540c\u6e90\u91cd\u7ec4\u6548\u7387\u3001\u5b9e\u73b0\u57fa\u56e0\u5b9a\u70b9\u66ff\u6362\u6216\u63d2\u5165\u7b49\u65b9\u9762\u8fdb\u884c\u4f18\u5316\u548c\u7a81\u7834\u30022023\u5e74\uff0c\u6709\u671bFDA\u6279\u51c6\u9996\u4f8b CRISPR \u57fa\u56e0\u7f16\u8f91\u4ea7\u54c1\u3002<\/p>\n<\/p>\n<p>05\u00a0\u5408\u6210\u751f\u7269\u6838\u5fc3\u6280\u672f<\/p>\n<p>\u9ad8\u901a\u91cf\u57fa\u56e0\u5408\u6210\u53ca\u751f\u4ea7\u5e73\u53f0<\/p>\n<p>\u57fa\u56e0\u5408\u6210\u662f\u5408\u6210\u751f\u7269\u7684\u5e95\u5c42\u6838\u5fc3\u6280\u672f\u4e4b\u4e00\u3002\u4e5f\u662f\u57fa\u56e0\u884c\u4e1a\u4ece\u201c\u8bfb\u201d\u5230\u771f\u6b63\u7684\u201c\u5199\u201d\u7684\u8de8\u8d8a\uff0c\u6280\u672f\u58c1\u5792\u66f4\u9ad8\u3002\u76ee\u524d\u57fa\u56e0\u5408\u6210\u7684\u9636\u6bb5\u662f\u9ad8\u901a\u91cfDNA\u5408\u6210\uff0c\u5305\u62ec\u5316\u5b66\u5408\u6210\u548c\u9176\u4fc3\u5408\u6210\u4e24\u5927\u7c7b\u3002<\/p>\n<\/p>\n<p>DNA\u5408\u6210\u7684\u672c\u8d28\u662f\u5c06\u8131\u6c27\u6838\u82f7\u9178\u5355\u4f53\u6309\u4e8b\u5148\u786e\u5b9a\u7684\u987a\u5e8f\u4f9d\u6b21\u8fde\u63a5\u8d77\u6765\uff0c\u5f62\u6210\u77ed\u94fe\u6216\u957f\u94fe\u7684\u6838\u9178\uff0c\u5e94\u7528\u4e8e\u5f15\u7269\u548c\u63a2\u9488\u7684\u751f\u4ea7\u3001\u5408\u6210\u751f\u7269\u5b66\u3001\u57fa\u56e0\u836f\u7269\u7814\u53d1\u4ee5\u53caDNA\u5b58\u50a8\u7b49\u9886\u57df\u3002<\/p>\n<\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBcxotvticu3Fe7bmaWIMZoF5lY3cJJvPlIp2JuTp88KdHj4Abn0f83hk9XUXuoVC3T70FKadRBWOw.png\" alt=\"RmFicvQBAkgBcxotvticu3Fe7bmaWIMZoF5lY3cJJvPlIp2JuTp88KdHj4Abn0f83hk9XUXuoVC3T70FKadRBWOw\"\/><\/figure><\/div>\n\n<\/p>\n<p>\u5e38\u89c4DNA\u5408\u6210\u65b9\u6cd5\u4ee5\u5355\u94fe\u5be1\u6838\u82f7\u9178\u5408\u6210\u4e3a\u57fa\u7840\u3002\u5be1\u6838\u82f7\u9178\u5316\u5b66\u5408\u6210\u8d77\u6b65\u4e8e\u4e8c\u5341\u4e16\u7eaa\u56db\u5341\u5e74\u4ee3\u672b\u30021955\u5e74\uff0c\u5251\u6865\u5927\u5b66\u7684Todd\u5b9e\u9a8c\u5ba4\u7b2c\u4e00\u6b21\u7528\u5316\u5b66\u6cd5\u6210\u529f\u5408\u6210\u4e86\u7b80\u5355\u4e8c\u805a\u5be1\u6838\u82f7\u9178\uff0c\u5e76\u4e8e1957\u5e74\u83b7\u5f97\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u3002<\/p>\n<\/p>\n<p>\u5316\u5b66\u5408\u6210\u6280\u672f\u76f8\u5bf9\u6210\u719f\u3002\u5316\u5b66\u5408\u6210\u5305\u62ec\u4e9a\u78f7\u9170\u80fa\u4e09\u916f\u5408\u6210\u6cd5\uff0c\u5149\u5316\u5b66\u8131\u4fdd\u62a4\u5408\u6210\u6cd5\u3001\u7535\u5316\u5b66\u5408\u6210\u6cd5\u3001\u6c22\u78f7\u9178\u916f\u5408\u6210\u6cd5\u3001\u4e24\u6b65\u5408\u6210\u6cd5\u3001\u53cc\u78b1\u57fa\u5355\u4f53\u5408\u6210\u6cd5\u7b49\u3002\u4ece\u5408\u6210\u7684\u57fa\u672c\u6280\u672f\u539f\u7406\u4e0a\u6765\u8bf4\uff0c\u4e9a\u78f7\u9170\u80fa\u4e09\u916f\u6cd5\u662f\u76ee\u524d\u4e3b\u6d41\u7684\u5be1\u6838\u82f7\u9178\u5316\u5b66\u5408\u6210\u7684\u539f\u7406\u57fa\u7840\u3002\u4ece\u8bbe\u5907\u5e73\u53f0\u4e0a\uff0c\u6839\u636e\u4e0d\u540c\u7684\u5e94\u7528\u573a\u666f\u53ef\u5206\u4e3a\u56fa\u76f8\u5408\u6210\u548c\u82af\u7247\u5408\u6210\u3002<\/p>\n<\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBcxotvticu3Fe7bmaWIMZoF4QAbWxDFBQU9J40REgzWMRouZPrUD54QD3PRicGTfGgnESH0oXSZyOw.png\" alt=\"RmFicvQBAkgBcxotvticu3Fe7bmaWIMZoF4QAbWxDFBQU9J40REgzWMRouZPrUD54QD3PRicGTfGgnESH0oXSZyOw\"\/><\/figure><\/div>\n\n<\/p>\n<div>DNA\u5408\u6210\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\uff0c\u57fa\u4e8e\u4e0d\u540c\u7684\u901a\u91cf\u5bf9\u5e94\u4e0d\u540c\u7684\u5e94\u7528\u573a\u666f\uff1a<\/div>\n<p>\u25cf\u8d85\u5fae\u91cf\uff08fmol \u7ea7\uff09\u548c\u5fae\u91cf\uff08pmol \u7ea7\uff09\uff1a\u7528\u4e8eCRISPR\u57fa\u56e0\u7f16\u8f91\u548cNGS\u9776\u5411\u6355\u83b7\u7b49\uff1b<\/p>\n<p>\u25cf\u5e38\u89c4\u91cf\uff08nmol \u7ea7\uff09\uff1a\u7528\u4e8e\u5e38\u89c4PCR\u548c\u8367\u5149\u5b9a\u91cfPCR\u7b49\uff1b<\/p>\n<p>\u25cf\u5927\u89c4\u6a21\u5408\u6210\uff08\u03bcmol \u7ea7\uff09\uff1a\u7528\u4e8e\u533b\u836f\u8bca\u65ad\u884c\u4e1a\u7684\u5de5\u4e1a\u539f\u6599\u3002<\/p>\n<\/p>\n<p>DNA\u5408\u6210\u4eea\u662fDNA\u5408\u6210\u7684\u6838\u5fc3\u88c5\u5907\u3002\u81ea\u4e0a\u4e16\u7eaa\u4e5d\u5341\u5e74\u4ee3\u8d77\uff0c\u82f1\u7f8e\u7b49\u56fd\u57fa\u4e8e\u7ecf\u5178\u5316\u5b66\u5408\u6210\u6cd5\u539f\u7406\u5f00\u59cb\u4e86DNA\u5408\u6210\u4eea\u7684\u7814\u53d1\u4e0e\u5546\u4e1a\u5316\uff0c\u76ee\u524d\u4ece\u7b2c\u4e00\u4ee3\u67f1\u5f0f\u5408\u6210\u4eea\u8fed\u4ee3\u5230\u7b2c\u4e8c\u4ee3\u9ad8\u901a\u91cf\u82af\u7247\u5408\u6210\u4eea\u3002<\/p>\n<\/p>\n<p>\u7b2c\u4e00\u4ee3\u67f1\u5f0f\u5408\u6210\u4eea\u7684\u5408\u6210\u8f7d\u4f53\u4e3a\u67f1\u72b6\u7ba1\u9053\u5408\u6210\u67f1\uff0c\u5185\u90e8\u586b\u5145\u7684\u53ef\u63a7\u591a\u5b54\u73bb\u7483 (CPG) \u4e3a\u53cd\u5e94\u4ecb\u8d28\uff0c\u901a\u8fc7\u7535\u8111\u7a0b\u5e8f\u63a7\u5236\u8bd5\u5242\u52a0\u5165\u4e0eCPG\u53cd\u5e94\uff0c\u6700\u7ec8\u5408\u6210\u5355\u94feDNA\u3002\u4ee3\u8868\u751f\u4ea7\u673a\u6784\u5305\u62ec\u7f8e\u56fd\u7684GE\u3001ABI\u3001Beckman Coulter \u7b49\u516c\u53f8\uff0c\u5fb7\u56fd\u7684 K&amp;A Laborgeraete\u3001PolyGen\u7b49\u516c\u53f8\uff0c\u97e9\u56fd\u7684Bioneer\u516c\u53f8\uff0c\u4e39\u9ea6\u7684 TAG Copenhagen A\/S\uff0c\u65e5\u672c\u7684\u745e\u7fc1\u533b\u7597\u682a\u5f0f\u4f1a\u793e\uff0c\u6211\u56fd\u7684\u64ce\u79d1\u751f\u7269\u3001\u9886\u5764\u3001\u4eea\u94c2\u7b49\u3002<\/p>\n<\/p>\n<p>\u7b2c\u4e8c\u4ee3\u82af\u7247\u5408\u6210\u4eea\uff0c\u4ee5\u82af\u7247\u4e3aDNA\u5408\u6210\u8f7d\u4f53\u3002\u5355\u5f20\u82af\u7247\u53ef\u5b9e\u73b0\u6210\u5343\u4e0a\u4e07\u6761\u957f\u5ea6\u4e0d\u7b49\u7684\u5355\u94fe DNA\u5408\u6210\u3002\u8be5\u7c7b\u578b\u8bbe\u5907\u53ef\u5728\u63d0\u4f9b\u9ad8\u901a\u91cf\u5408\u6210\u7684\u540c\u65f6\u964d\u4f4e\u8bd5\u5242\u7684\u6d88\u8017\uff0c\u521d\u6b65\u5b9e\u73b0\u4f4e\u6210\u672c\u9ad8\u901a\u91cf\u7684\u5be1\u6838\u82f7\u9178\u5408\u6210\u3002<\/p>\n<\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBcxotvticu3Fe7bmaWIMZoFV9p9YbDfudUF8MB3f4yKgjkibp1O6wQouC2ibAKJibFJoM3KkrUAO8HSA.png\" alt=\"RmFicvQBAkgBcxotvticu3Fe7bmaWIMZoFV9p9YbDfudUF8MB3f4yKgjkibp1O6wQouC2ibAKJibFJoM3KkrUAO8HSA\"\/><\/figure><\/div>\n\n<\/p>\n<p>2022 \u5e74\u6211\u56fd\u5b9e\u73b0\u9ad8\u901a\u91cfDNA\u5408\u6210\u4eea\u7684\u56fd\u4ea7\u5316\uff0c\u534e\u5927mMPS-M200\u5408\u6210\u4eea\u6253\u7834\u56fd\u5916\u79d1\u6280\u521b\u65b0\u6280\u672f\u58c1\u5792\u3002\u540c\u5e74\uff0c\u534e\u5927\u843d\u5730\u5e38\u5dde\u642d\u5efa\u5408\u6210\u751f\u7269\u5b66\u5927\u5e73\u53f0\uff0c\u5176\u4ea7\u51fa\u5c06\u53ef\u8fbe\u5230\u6bcf\u53f0\u673a\u566810\u4ebf\u78b1\u57fa\/\u5e74\uff0c\u6574\u4f53\u4ea7\u80fd\u8fbe\u5343\u4ebf\u78b1\u57fa\/\u5e74\uff0c\u5e76\u6210\u7acb\u5e38\u5dde\u65b0\u4e00\u4ea7\u751f\u547d\u79d1\u6280\u6709\u9650\u516c\u53f8\u3002<\/p>\n<\/p>\n<p>\u76f8\u5bf9\u4f20\u7edf\u4e9a\u78f7\u9170\u80fa\u5316\u5b66\u5408\u6210\u6cd5\u7684\u5316\u5b66\u53cd\u5e94\u6548\u7387\u9650\u5236\u5408\u6210\u4ea7\u7269\u957f\u5ea6\uff08200-250 nt\uff09\uff0c\u4ee5\u53ca\u5f3a\u9178\u3001\u5f3a\u6c27\u5316\u5242\u7b49\u73af\u5883\u4e0d\u53cb\u597d\u4ea7\u7269\u7684\u5904\u7406\u8d39\u7528\u9ad8\u6602\uff0c\u8fd1\u51e0\u5e74\u51fa\u73b0\u7684\u751f\u7269\u9176\u4fc3DNA\u5408\u6210\u6280\u672f\uff0c\u901a\u5e38\u5728\u6c34\u76f8\u73af\u5883\u4e0b\u8fdb\u884c\uff0c\u53ef\u6709\u6548\u907f\u514d\u4e0a\u8ff0\u95ee\u9898\uff0c\u6709\u671b\u4ee5\u66f4\u4f4e\u7684\u6210\u672c\u5408\u6210\u66f4\u957f\u7684DNA\u5206\u5b50\u3002\u9176\u4fc3\u5408\u6210\u4ee3\u8868\u4f01\u4e1a\u6709\u5305\u62ec Molecular Assemblies\u3001Nuclera\u3001DNA Script\u3001Camena Bioscience\u3001Ansa Biotechnologies\u3001Kern Systems\u3002\u56fd\u5185\u5e02\u573a\u8d77\u6b65\u8f83\u665a\uff0c2022\u5e74\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u5929\u6d25\u5de5\u4e1a\u751f\u7269\u6280\u672f\u7814\u7a76\u6240\u7814\u7a76\u56e2\u961f\u5229\u7528\u6539\u9020\u83b7\u5f97\u7684\u5408\u6210\u9176\u521b\u5efa\u4e86\u4e8c\u6b65\u5faa\u73af\u9176\u4fc3DNA\u5408\u6210\u6280\u672f\u3002<\/p>\n<\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBcxotvticu3Fe7bmaWIMZoFTlibibicMqNLhPY5SvaL9yRMzRBoQvxdUIBPicoHeQzzib3iaicFouZ9MljibA.png\" alt=\"RmFicvQBAkgBcxotvticu3Fe7bmaWIMZoFTlibibicMqNLhPY5SvaL9yRMzRBoQvxdUIBPicoHeQzzib3iaicFouZ9MljibA\"\/><\/figure><\/div>\n\n<p>\u5c55\u671b\u672a\u6765 5~10 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src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBcxotvticu3Fe7bmaWIMZoFcHpBQlfHD5nSmsQuTu1ym2Zxv74gWRubAz6fVibNBPTH2ySYLsSkYLQ.jpeg\" alt=\"RmFicvQBAkgBcxotvticu3Fe7bmaWIMZoFcHpBQlfHD5nSmsQuTu1ym2Zxv74gWRubAz6fVibNBPTH2ySYLsSkYLQ\"\/><\/figure><\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBcxotvticu3Fe7bmaWIMZoF0sGpDFJXdVFoAFAzfMDYBibNjNpbnHfxPYbO8mYDhwMQ4E2ibtAw2jibQ.png\" alt=\"RmFicvQBAkgBcxotvticu3Fe7bmaWIMZoF0sGpDFJXdVFoAFAzfMDYBibNjNpbnHfxPYbO8mYDhwMQ4E2ibtAw2jibQ\"\/><\/figure><\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBcxotvticu3Fe7bmaWIMZoFqdFUgy7sBZsWX9iccP3ibvgKQ7p3vIGOgCCgUia8b8CSrOC5IPJhPHEibQ.png\" 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